Found 36 hits Enz. Inhib. hit(s) with all data for entry = 50029751 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50287545
(4-[4-Ethoxy-3-(1-methyl-7-oxo-3-propyl-6,7-dihydro...)Show SMILES CCCc1nn(C)c2c1nc([nH]c2=O)-c1cc(ccc1OCC)S(=O)(=O)N1CCN(CC1)C(N)=O Show InChI InChI=1S/C22H29N7O5S/c1-4-6-16-18-19(27(3)26-16)21(30)25-20(24-18)15-13-14(7-8-17(15)34-5-2)35(32,33)29-11-9-28(10-12-29)22(23)31/h7-8,13H,4-6,9-12H2,1-3H3,(H2,23,31)(H,24,25,30) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article
| n/a | n/a | 2.10 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of Phosphodiesterase 5 from rabbit platelets |
Bioorg Med Chem Lett 6: 1819-1824 (1996)
Article DOI: 10.1016/0960-894X(96)00323-X BindingDB Entry DOI: 10.7270/Q2G73DQW |
More data for this Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM14390
(5-[2-ethoxy-5-(4-methyl-1-piperazinylsulfonyl)phen...)Show SMILES CCCc1nn(C)c2c1nc([nH]c2=O)-c1cc(ccc1OCC)S(=O)(=O)N1CCN(C)CC1 Show InChI InChI=1S/C22H30N6O4S/c1-5-7-17-19-20(27(4)25-17)22(29)24-21(23-19)16-14-15(8-9-18(16)32-6-2)33(30,31)28-12-10-26(3)11-13-28/h8-9,14H,5-7,10-13H2,1-4H3,(H,23,24,29) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
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CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem
Patents
Similars
| MMDB PDB Article
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of Phosphodiesterase 5 from human corpus cavernosum |
Bioorg Med Chem Lett 6: 1819-1824 (1996)
Article DOI: 10.1016/0960-894X(96)00323-X BindingDB Entry DOI: 10.7270/Q2G73DQW |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM14390
(5-[2-ethoxy-5-(4-methyl-1-piperazinylsulfonyl)phen...)Show SMILES CCCc1nn(C)c2c1nc([nH]c2=O)-c1cc(ccc1OCC)S(=O)(=O)N1CCN(C)CC1 Show InChI InChI=1S/C22H30N6O4S/c1-5-7-17-19-20(27(4)25-17)22(29)24-21(23-19)16-14-15(8-9-18(16)32-6-2)33(30,31)28-12-10-26(3)11-13-28/h8-9,14H,5-7,10-13H2,1-4H3,(H,23,24,29) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
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CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem
Patents
Similars
| MMDB PDB Article
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of Phosphodiesterase 5 from human corpus cavernosum |
Bioorg Med Chem Lett 6: 1819-1824 (1996)
Article DOI: 10.1016/0960-894X(96)00323-X BindingDB Entry DOI: 10.7270/Q2G73DQW |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50287543
(5-(2-ethoxy-5-(piperazin-1-ylsulfonyl)phenyl)-1-me...)Show SMILES CCCc1nn(C)c2c1nc([nH]c2=O)-c1cc(ccc1OCC)S(=O)(=O)N1CCNCC1 Show InChI InChI=1S/C21H28N6O4S/c1-4-6-16-18-19(26(3)25-16)21(28)24-20(23-18)15-13-14(7-8-17(15)31-5-2)32(29,30)27-11-9-22-10-12-27/h7-8,13,22H,4-6,9-12H2,1-3H3,(H,23,24,28) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
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CHEMBL MCE PC cid PC sid UniChem
Patents
Similars
| Article
| n/a | n/a | 5.70 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of Phosphodiesterase 5 from rabbit platelets |
Bioorg Med Chem Lett 6: 1819-1824 (1996)
Article DOI: 10.1016/0960-894X(96)00323-X BindingDB Entry DOI: 10.7270/Q2G73DQW |
More data for this Ligand-Target Pair | 3D Structure (docked) |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50287550
(5-(2-ethoxy-5-(4-(2-hydroxyethyl)piperazin-1-ylsul...)Show SMILES CCCc1nn(C)c2c1nc([nH]c2=O)-c1cc(ccc1OCC)S(=O)(=O)N1CCN(CCO)CC1 Show InChI InChI=1S/C23H32N6O5S/c1-4-6-18-20-21(27(3)26-18)23(31)25-22(24-20)17-15-16(7-8-19(17)34-5-2)35(32,33)29-11-9-28(10-12-29)13-14-30/h7-8,15,30H,4-6,9-14H2,1-3H3,(H,24,25,31) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
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CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article
| n/a | n/a | 19 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of Phosphodiesterase 5 from rabbit platelets |
Bioorg Med Chem Lett 6: 1819-1824 (1996)
Article DOI: 10.1016/0960-894X(96)00323-X BindingDB Entry DOI: 10.7270/Q2G73DQW |
More data for this Ligand-Target Pair | 3D Structure (docked) |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50111899
(5-(2-Ethoxy-phenyl)-1-methyl-3-propyl-1,6-dihydro-...)Show InChI InChI=1S/C17H20N4O2/c1-4-8-12-14-15(21(3)20-12)17(22)19-16(18-14)11-9-6-7-10-13(11)23-5-2/h6-7,9-10H,4-5,8H2,1-3H3,(H,18,19,22) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
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CHEMBL MCE PC cid PC sid UniChem
Patents
Similars
| Article
| n/a | n/a | 27 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of Phosphodiesterase 5 from rabbit platelets |
Bioorg Med Chem Lett 6: 1819-1824 (1996)
Article DOI: 10.1016/0960-894X(96)00323-X BindingDB Entry DOI: 10.7270/Q2G73DQW |
More data for this Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50111899
(5-(2-Ethoxy-phenyl)-1-methyl-3-propyl-1,6-dihydro-...)Show InChI InChI=1S/C17H20N4O2/c1-4-8-12-14-15(21(3)20-12)17(22)19-16(18-14)11-9-6-7-10-13(11)23-5-2/h6-7,9-10H,4-5,8H2,1-3H3,(H,18,19,22) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid UniChem
Patents
Similars
| Article
| n/a | n/a | 27 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of Phosphodiesterase 5 from human corpus cavernosum |
Bioorg Med Chem Lett 6: 1819-1824 (1996)
Article DOI: 10.1016/0960-894X(96)00323-X BindingDB Entry DOI: 10.7270/Q2G73DQW |
More data for this Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50169640
(5-(2-Ethoxy-phenyl)-3-propyl-1,6-dihydro-pyrazolo[...)Show InChI InChI=1S/C16H18N4O2/c1-3-7-11-13-14(20-19-11)16(21)18-15(17-13)10-8-5-6-9-12(10)22-4-2/h5-6,8-9H,3-4,7H2,1-2H3,(H,19,20)(H,17,18,21) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article
| n/a | n/a | 82 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of Phosphodiesterase 5 from human corpus cavernosum |
Bioorg Med Chem Lett 6: 1819-1824 (1996)
Article DOI: 10.1016/0960-894X(96)00323-X BindingDB Entry DOI: 10.7270/Q2G73DQW |
More data for this Ligand-Target Pair | |
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B
(Homo sapiens (Human)) | BDBM50169640
(5-(2-Ethoxy-phenyl)-3-propyl-1,6-dihydro-pyrazolo[...)Show InChI InChI=1S/C16H18N4O2/c1-3-7-11-13-14(20-19-11)16(21)18-15(17-13)10-8-5-6-9-12(10)22-4-2/h5-6,8-9H,3-4,7H2,1-2H3,(H,19,20)(H,17,18,21) | PDB MMDB
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article
| n/a | n/a | >100 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of Phosphodiesterase 3 from rabbit platelets |
Bioorg Med Chem Lett 6: 1819-1824 (1996)
Article DOI: 10.1016/0960-894X(96)00323-X BindingDB Entry DOI: 10.7270/Q2G73DQW |
More data for this Ligand-Target Pair | |
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B/Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C/Phosphodiesterase
(Rattus norvegicus) | BDBM50287545
(4-[4-Ethoxy-3-(1-methyl-7-oxo-3-propyl-6,7-dihydro...)Show SMILES CCCc1nn(C)c2c1nc([nH]c2=O)-c1cc(ccc1OCC)S(=O)(=O)N1CCN(CC1)C(N)=O Show InChI InChI=1S/C22H29N7O5S/c1-4-6-16-18-19(27(3)26-16)21(30)25-20(24-18)15-13-14(7-8-17(15)34-5-2)35(32,33)29-11-9-28(10-12-29)22(23)31/h7-8,13H,4-6,9-12H2,1-3H3,(H2,23,31)(H,24,25,30) | PDB
KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article
| n/a | n/a | 110 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of Phosphodiesterase 1 from rat liver |
Bioorg Med Chem Lett 6: 1819-1824 (1996)
Article DOI: 10.1016/0960-894X(96)00323-X BindingDB Entry DOI: 10.7270/Q2G73DQW |
More data for this Ligand-Target Pair | |
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B/Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C/Phosphodiesterase
(Rattus norvegicus) | BDBM14390
(5-[2-ethoxy-5-(4-methyl-1-piperazinylsulfonyl)phen...)Show SMILES CCCc1nn(C)c2c1nc([nH]c2=O)-c1cc(ccc1OCC)S(=O)(=O)N1CCN(C)CC1 Show InChI InChI=1S/C22H30N6O4S/c1-5-7-17-19-20(27(4)25-17)22(29)24-21(23-19)16-14-15(8-9-18(16)32-6-2)33(30,31)28-12-10-26(3)11-13-28/h8-9,14H,5-7,10-13H2,1-4H3,(H,23,24,29) | PDB
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CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem
Patents
Similars
| Article
| n/a | n/a | 260 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of Phosphodiesterase 1 from rat liver |
Bioorg Med Chem Lett 6: 1819-1824 (1996)
Article DOI: 10.1016/0960-894X(96)00323-X BindingDB Entry DOI: 10.7270/Q2G73DQW |
More data for this Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50287546
(5-(2-Ethoxy-phenyl)-1,3-dimethyl-1,6-dihydro-pyraz...)Show InChI InChI=1S/C15H16N4O2/c1-4-21-11-8-6-5-7-10(11)14-16-12-9(2)18-19(3)13(12)15(20)17-14/h5-8H,4H2,1-3H3,(H,16,17,20) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article
| n/a | n/a | 330 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of Phosphodiesterase 5 from human corpus cavernosum |
Bioorg Med Chem Lett 6: 1819-1824 (1996)
Article DOI: 10.1016/0960-894X(96)00323-X BindingDB Entry DOI: 10.7270/Q2G73DQW |
More data for this Ligand-Target Pair | |
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B/Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C/Phosphodiesterase
(Rattus norvegicus) | BDBM50287543
(5-(2-ethoxy-5-(piperazin-1-ylsulfonyl)phenyl)-1-me...)Show SMILES CCCc1nn(C)c2c1nc([nH]c2=O)-c1cc(ccc1OCC)S(=O)(=O)N1CCNCC1 Show InChI InChI=1S/C21H28N6O4S/c1-4-6-16-18-19(26(3)25-16)21(28)24-20(23-18)15-13-14(7-8-17(15)31-5-2)32(29,30)27-11-9-22-10-12-27/h7-8,13,22H,4-6,9-12H2,1-3H3,(H,23,24,28) | PDB
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CHEMBL MCE PC cid PC sid UniChem
Patents
Similars
| Article
| n/a | n/a | 390 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of Phosphodiesterase 1 from rat liver |
Bioorg Med Chem Lett 6: 1819-1824 (1996)
Article DOI: 10.1016/0960-894X(96)00323-X BindingDB Entry DOI: 10.7270/Q2G73DQW |
More data for this Ligand-Target Pair | |
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B/Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C/Phosphodiesterase
(Rattus norvegicus) | BDBM50287550
(5-(2-ethoxy-5-(4-(2-hydroxyethyl)piperazin-1-ylsul...)Show SMILES CCCc1nn(C)c2c1nc([nH]c2=O)-c1cc(ccc1OCC)S(=O)(=O)N1CCN(CCO)CC1 Show InChI InChI=1S/C23H32N6O5S/c1-4-6-18-20-21(27(3)26-18)23(31)25-22(24-20)17-15-16(7-8-19(17)34-5-2)35(32,33)29-11-9-28(10-12-29)13-14-30/h7-8,15,30H,4-6,9-14H2,1-3H3,(H,24,25,31) | PDB
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CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article
| n/a | n/a | 460 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of Phosphodiesterase 1 from rat liver |
Bioorg Med Chem Lett 6: 1819-1824 (1996)
Article DOI: 10.1016/0960-894X(96)00323-X BindingDB Entry DOI: 10.7270/Q2G73DQW |
More data for this Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50287551
(CHEMBL52245 | N-(2-(1-methyl-7-oxo-3-propyl-6,7-di...)Show SMILES CCCc1nn(C)c2c1nc([nH]c2=O)-c1ccccc1NS(C)(=O)=O Show InChI InChI=1S/C16H19N5O3S/c1-4-7-12-13-14(21(2)19-12)16(22)18-15(17-13)10-8-5-6-9-11(10)20-25(3,23)24/h5-6,8-9,20H,4,7H2,1-3H3,(H,17,18,22) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article
| n/a | n/a | 780 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of Phosphodiesterase 5 from rabbit platelets |
Bioorg Med Chem Lett 6: 1819-1824 (1996)
Article DOI: 10.1016/0960-894X(96)00323-X BindingDB Entry DOI: 10.7270/Q2G73DQW |
More data for this Ligand-Target Pair | |
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B/Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C/Phosphodiesterase
(Rattus norvegicus) | BDBM50111899
(5-(2-Ethoxy-phenyl)-1-methyl-3-propyl-1,6-dihydro-...)Show InChI InChI=1S/C17H20N4O2/c1-4-8-12-14-15(21(3)20-12)17(22)19-16(18-14)11-9-6-7-10-13(11)23-5-2/h6-7,9-10H,4-5,8H2,1-3H3,(H,18,19,22) | PDB
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CHEMBL MCE PC cid PC sid UniChem
Patents
Similars
| Article
| n/a | n/a | 790 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of Phosphodiesterase 1 from rat liver |
Bioorg Med Chem Lett 6: 1819-1824 (1996)
Article DOI: 10.1016/0960-894X(96)00323-X BindingDB Entry DOI: 10.7270/Q2G73DQW |
More data for this Ligand-Target Pair | |
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B/Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C/Phosphodiesterase
(Rattus norvegicus) | BDBM50169640
(5-(2-Ethoxy-phenyl)-3-propyl-1,6-dihydro-pyrazolo[...)Show InChI InChI=1S/C16H18N4O2/c1-3-7-11-13-14(20-19-11)16(21)18-15(17-13)10-8-5-6-9-12(10)22-4-2/h5-6,8-9H,3-4,7H2,1-2H3,(H,19,20)(H,17,18,21) | PDB
KEGG
UniProtKB/SwissProt
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| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article
| n/a | n/a | 860 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of Phosphodiesterase 1 from rat liver |
Bioorg Med Chem Lett 6: 1819-1824 (1996)
Article DOI: 10.1016/0960-894X(96)00323-X BindingDB Entry DOI: 10.7270/Q2G73DQW |
More data for this Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50287549
(5-(2-(cyclopropylmethoxy)phenyl)-1-methyl-3-propyl...)Show InChI InChI=1S/C19H22N4O2/c1-3-6-14-16-17(23(2)22-14)19(24)21-18(20-16)13-7-4-5-8-15(13)25-11-12-9-10-12/h4-5,7-8,12H,3,6,9-11H2,1-2H3,(H,20,21,24) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article
| n/a | n/a | 960 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of Phosphodiesterase 5 from rabbit platelets |
Bioorg Med Chem Lett 6: 1819-1824 (1996)
Article DOI: 10.1016/0960-894X(96)00323-X BindingDB Entry DOI: 10.7270/Q2G73DQW |
More data for this Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50287544
(5-(2-Hydroxy-phenyl)-3-propyl-1,6-dihydro-pyrazolo...)Show InChI InChI=1S/C14H14N4O2/c1-2-5-9-11-12(18-17-9)14(20)16-13(15-11)8-6-3-4-7-10(8)19/h3-4,6-7,19H,2,5H2,1H3,(H,17,18)(H,15,16,20) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
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CHEMBL PC cid PC sid UniChem
Similars
| Article
| n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of Phosphodiesterase 5 from rabbit platelets |
Bioorg Med Chem Lett 6: 1819-1824 (1996)
Article DOI: 10.1016/0960-894X(96)00323-X BindingDB Entry DOI: 10.7270/Q2G73DQW |
More data for this Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM14363
(3-(2-propoxyphenyl)-2,4,7,8,9-pentazabicyclo[4.3.0...)Show InChI InChI=1S/C13H13N5O2/c1-2-7-20-9-6-4-3-5-8(9)11-14-12-10(13(19)15-11)16-18-17-12/h3-6H,2,7H2,1H3,(H2,14,15,16,17,18,19) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
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PC cid PC sid UniChem
Patents
Similars
| Article
| n/a | n/a | 2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of Phosphodiesterase 5 from human corpus cavernosum |
Bioorg Med Chem Lett 6: 1819-1824 (1996)
Article DOI: 10.1016/0960-894X(96)00323-X BindingDB Entry DOI: 10.7270/Q2G73DQW |
More data for this Ligand-Target Pair | |
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B/Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C/Phosphodiesterase
(Rattus norvegicus) | BDBM50287546
(5-(2-Ethoxy-phenyl)-1,3-dimethyl-1,6-dihydro-pyraz...)Show InChI InChI=1S/C15H16N4O2/c1-4-21-11-8-6-5-7-10(11)14-16-12-9(2)18-19(3)13(12)15(20)17-14/h5-8H,4H2,1-3H3,(H,16,17,20) | PDB
KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article
| n/a | n/a | 3.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of Phosphodiesterase 5 from rabbit platelets |
Bioorg Med Chem Lett 6: 1819-1824 (1996)
Article DOI: 10.1016/0960-894X(96)00323-X BindingDB Entry DOI: 10.7270/Q2G73DQW |
More data for this Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50287547
(1-Methyl-5-(2-nitro-phenyl)-3-propyl-1,6-dihydro-p...)Show SMILES CCCc1nn(C)c2c1nc([nH]c2=O)-c1ccccc1[N+]([O-])=O Show InChI InChI=1S/C15H15N5O3/c1-3-6-10-12-13(19(2)18-10)15(21)17-14(16-12)9-7-4-5-8-11(9)20(22)23/h4-5,7-8H,3,6H2,1-2H3,(H,16,17,21) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article
| n/a | n/a | 4.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of Phosphodiesterase 5 from rabbit platelets |
Bioorg Med Chem Lett 6: 1819-1824 (1996)
Article DOI: 10.1016/0960-894X(96)00323-X BindingDB Entry DOI: 10.7270/Q2G73DQW |
More data for this Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50287548
(5-Phenyl-3-propyl-1,6-dihydro-pyrazolo[4,3-d]pyrim...)Show InChI InChI=1S/C14H14N4O/c1-2-6-10-11-12(18-17-10)14(19)16-13(15-11)9-7-4-3-5-8-9/h3-5,7-8H,2,6H2,1H3,(H,17,18)(H,15,16,19) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article
| n/a | n/a | 4.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of Phosphodiesterase 5 from rabbit platelets |
Bioorg Med Chem Lett 6: 1819-1824 (1996)
Article DOI: 10.1016/0960-894X(96)00323-X BindingDB Entry DOI: 10.7270/Q2G73DQW |
More data for this Ligand-Target Pair | |
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B/Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C/Phosphodiesterase
(Rattus norvegicus) | BDBM14363
(3-(2-propoxyphenyl)-2,4,7,8,9-pentazabicyclo[4.3.0...)Show InChI InChI=1S/C13H13N5O2/c1-2-7-20-9-6-4-3-5-8(9)11-14-12-10(13(19)15-11)16-18-17-12/h3-6H,2,7H2,1H3,(H2,14,15,16,17,18,19) | PDB
KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
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PC cid PC sid UniChem
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| n/a | n/a | 9.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of Phosphodiesterase 1 from rat liver |
Bioorg Med Chem Lett 6: 1819-1824 (1996)
Article DOI: 10.1016/0960-894X(96)00323-X BindingDB Entry DOI: 10.7270/Q2G73DQW |
More data for this Ligand-Target Pair | |
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B
(Homo sapiens (Human)) | BDBM50287545
(4-[4-Ethoxy-3-(1-methyl-7-oxo-3-propyl-6,7-dihydro...)Show SMILES CCCc1nn(C)c2c1nc([nH]c2=O)-c1cc(ccc1OCC)S(=O)(=O)N1CCN(CC1)C(N)=O Show InChI InChI=1S/C22H29N7O5S/c1-4-6-16-18-19(27(3)26-16)21(30)25-20(24-18)15-13-14(7-8-17(15)34-5-2)35(32,33)29-11-9-28(10-12-29)22(23)31/h7-8,13H,4-6,9-12H2,1-3H3,(H2,23,31)(H,24,25,30) | PDB MMDB
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article
| n/a | n/a | 3.40E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of Phosphodiesterase 3 from rabbit platelets |
Bioorg Med Chem Lett 6: 1819-1824 (1996)
Article DOI: 10.1016/0960-894X(96)00323-X BindingDB Entry DOI: 10.7270/Q2G73DQW |
More data for this Ligand-Target Pair | |
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B
(Homo sapiens (Human)) | BDBM50287549
(5-(2-(cyclopropylmethoxy)phenyl)-1-methyl-3-propyl...)Show InChI InChI=1S/C19H22N4O2/c1-3-6-14-16-17(23(2)22-14)19(24)21-18(20-16)13-7-4-5-8-15(13)25-11-12-9-10-12/h4-5,7-8,12H,3,6,9-11H2,1-2H3,(H,20,21,24) | PDB MMDB
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article
| n/a | n/a | 4.70E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of Phosphodiesterase 3 from rabbit platelets |
Bioorg Med Chem Lett 6: 1819-1824 (1996)
Article DOI: 10.1016/0960-894X(96)00323-X BindingDB Entry DOI: 10.7270/Q2G73DQW |
More data for this Ligand-Target Pair | |
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B
(Homo sapiens (Human)) | BDBM50287550
(5-(2-ethoxy-5-(4-(2-hydroxyethyl)piperazin-1-ylsul...)Show SMILES CCCc1nn(C)c2c1nc([nH]c2=O)-c1cc(ccc1OCC)S(=O)(=O)N1CCN(CCO)CC1 Show InChI InChI=1S/C23H32N6O5S/c1-4-6-18-20-21(27(3)26-18)23(31)25-22(24-20)17-15-16(7-8-19(17)34-5-2)35(32,33)29-11-9-28(10-12-29)13-14-30/h7-8,15,30H,4-6,9-14H2,1-3H3,(H,24,25,31) | PDB MMDB
UniProtKB/SwissProt
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CHEMBL PC cid PC sid UniChem
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| n/a | n/a | 6.20E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of Phosphodiesterase 5 from rabbit platelets |
Bioorg Med Chem Lett 6: 1819-1824 (1996)
Article DOI: 10.1016/0960-894X(96)00323-X BindingDB Entry DOI: 10.7270/Q2G73DQW |
More data for this Ligand-Target Pair | |
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B
(Homo sapiens (Human)) | BDBM50287548
(5-Phenyl-3-propyl-1,6-dihydro-pyrazolo[4,3-d]pyrim...)Show InChI InChI=1S/C14H14N4O/c1-2-6-10-11-12(18-17-10)14(19)16-13(15-11)9-7-4-3-5-8-9/h3-5,7-8H,2,6H2,1H3,(H,17,18)(H,15,16,19) | PDB MMDB
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article
| n/a | n/a | 6.30E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of Phosphodiesterase 3 from rabbit platelets |
Bioorg Med Chem Lett 6: 1819-1824 (1996)
Article DOI: 10.1016/0960-894X(96)00323-X BindingDB Entry DOI: 10.7270/Q2G73DQW |
More data for this Ligand-Target Pair | |
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B
(Homo sapiens (Human)) | BDBM14390
(5-[2-ethoxy-5-(4-methyl-1-piperazinylsulfonyl)phen...)Show SMILES CCCc1nn(C)c2c1nc([nH]c2=O)-c1cc(ccc1OCC)S(=O)(=O)N1CCN(C)CC1 Show InChI InChI=1S/C22H30N6O4S/c1-5-7-17-19-20(27(4)25-17)22(29)24-21(23-19)16-14-15(8-9-18(16)32-6-2)33(30,31)28-12-10-26(3)11-13-28/h8-9,14H,5-7,10-13H2,1-4H3,(H,23,24,29) | PDB MMDB
UniProtKB/SwissProt
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CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem
Patents
Similars
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| n/a | n/a | 6.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of Phosphodiesterase 3 from rabbit platelets |
Bioorg Med Chem Lett 6: 1819-1824 (1996)
Article DOI: 10.1016/0960-894X(96)00323-X BindingDB Entry DOI: 10.7270/Q2G73DQW |
More data for this Ligand-Target Pair | |
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B
(Homo sapiens (Human)) | BDBM50287551
(CHEMBL52245 | N-(2-(1-methyl-7-oxo-3-propyl-6,7-di...)Show SMILES CCCc1nn(C)c2c1nc([nH]c2=O)-c1ccccc1NS(C)(=O)=O Show InChI InChI=1S/C16H19N5O3S/c1-4-7-12-13-14(21(2)19-12)16(22)18-15(17-13)10-8-5-6-9-11(10)20-25(3,23)24/h5-6,8-9,20H,4,7H2,1-3H3,(H,17,18,22) | PDB MMDB
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article
| n/a | n/a | 8.30E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of Phosphodiesterase 3 from rabbit platelets |
Bioorg Med Chem Lett 6: 1819-1824 (1996)
Article DOI: 10.1016/0960-894X(96)00323-X BindingDB Entry DOI: 10.7270/Q2G73DQW |
More data for this Ligand-Target Pair | |
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B
(Homo sapiens (Human)) | BDBM50287547
(1-Methyl-5-(2-nitro-phenyl)-3-propyl-1,6-dihydro-p...)Show SMILES CCCc1nn(C)c2c1nc([nH]c2=O)-c1ccccc1[N+]([O-])=O Show InChI InChI=1S/C15H15N5O3/c1-3-6-10-12-13(19(2)18-10)15(21)17-14(16-12)9-7-4-5-8-11(9)20(22)23/h4-5,7-8H,3,6H2,1-2H3,(H,16,17,21) | PDB MMDB
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of Phosphodiesterase 3 from rabbit platelets |
Bioorg Med Chem Lett 6: 1819-1824 (1996)
Article DOI: 10.1016/0960-894X(96)00323-X BindingDB Entry DOI: 10.7270/Q2G73DQW |
More data for this Ligand-Target Pair | |
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B
(Homo sapiens (Human)) | BDBM14363
(3-(2-propoxyphenyl)-2,4,7,8,9-pentazabicyclo[4.3.0...)Show InChI InChI=1S/C13H13N5O2/c1-2-7-20-9-6-4-3-5-8(9)11-14-12-10(13(19)15-11)16-18-17-12/h3-6H,2,7H2,1H3,(H2,14,15,16,17,18,19) | PDB MMDB
UniProtKB/SwissProt
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| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of Phosphodiesterase 3 from rabbit platelets |
Bioorg Med Chem Lett 6: 1819-1824 (1996)
Article DOI: 10.1016/0960-894X(96)00323-X BindingDB Entry DOI: 10.7270/Q2G73DQW |
More data for this Ligand-Target Pair | |
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B
(Homo sapiens (Human)) | BDBM50287546
(5-(2-Ethoxy-phenyl)-1,3-dimethyl-1,6-dihydro-pyraz...)Show InChI InChI=1S/C15H16N4O2/c1-4-21-11-8-6-5-7-10(11)14-16-12-9(2)18-19(3)13(12)15(20)17-14/h5-8H,4H2,1-3H3,(H,16,17,20) | PDB MMDB
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of Phosphodiesterase 3 from rabbit platelets |
Bioorg Med Chem Lett 6: 1819-1824 (1996)
Article DOI: 10.1016/0960-894X(96)00323-X BindingDB Entry DOI: 10.7270/Q2G73DQW |
More data for this Ligand-Target Pair | |
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B
(Homo sapiens (Human)) | BDBM50287544
(5-(2-Hydroxy-phenyl)-3-propyl-1,6-dihydro-pyrazolo...)Show InChI InChI=1S/C14H14N4O2/c1-2-5-9-11-12(18-17-9)14(20)16-13(15-11)8-6-3-4-7-10(8)19/h3-4,6-7,19H,2,5H2,1H3,(H,17,18)(H,15,16,20) | PDB MMDB
UniProtKB/SwissProt
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| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of Phosphodiesterase 3 from rabbit platelets |
Bioorg Med Chem Lett 6: 1819-1824 (1996)
Article DOI: 10.1016/0960-894X(96)00323-X BindingDB Entry DOI: 10.7270/Q2G73DQW |
More data for this Ligand-Target Pair | |
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B
(Homo sapiens (Human)) | BDBM50287543
(5-(2-ethoxy-5-(piperazin-1-ylsulfonyl)phenyl)-1-me...)Show SMILES CCCc1nn(C)c2c1nc([nH]c2=O)-c1cc(ccc1OCC)S(=O)(=O)N1CCNCC1 Show InChI InChI=1S/C21H28N6O4S/c1-4-6-16-18-19(26(3)25-16)21(28)24-20(23-18)15-13-14(7-8-17(15)31-5-2)32(29,30)27-11-9-22-10-12-27/h7-8,13,22H,4-6,9-12H2,1-3H3,(H,23,24,28) | PDB MMDB
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| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of Phosphodiesterase 3 from rabbit platelets |
Bioorg Med Chem Lett 6: 1819-1824 (1996)
Article DOI: 10.1016/0960-894X(96)00323-X BindingDB Entry DOI: 10.7270/Q2G73DQW |
More data for this Ligand-Target Pair | |
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B
(Homo sapiens (Human)) | BDBM50111899
(5-(2-Ethoxy-phenyl)-1-methyl-3-propyl-1,6-dihydro-...)Show InChI InChI=1S/C17H20N4O2/c1-4-8-12-14-15(21(3)20-12)17(22)19-16(18-14)11-9-6-7-10-13(11)23-5-2/h6-7,9-10H,4-5,8H2,1-3H3,(H,18,19,22) | PDB MMDB
UniProtKB/SwissProt
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| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of Phosphodiesterase 3 from rabbit platelets |
Bioorg Med Chem Lett 6: 1819-1824 (1996)
Article DOI: 10.1016/0960-894X(96)00323-X BindingDB Entry DOI: 10.7270/Q2G73DQW |
More data for this Ligand-Target Pair | |