Found 8 hits Enz. Inhib. hit(s) with all data for entry = 50032916 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Geranylgeranyl pyrophosphate synthase
(Homo sapiens (Human)) | BDBM50336506
(2-(decyl(methyl)amino)ethane-1,1-diyldiphosphonic ...)Show InChI InChI=1S/C13H31NO6P2/c1-3-4-5-6-7-8-9-10-11-14(2)12-13(21(15,16)17)22(18,19)20/h13H,3-12H2,1-2H3,(H2,15,16,17)(H2,18,19,20) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 3.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Immunology
Curated by ChEMBL
| Assay Description Inhibition of human GGPPS |
Antimicrob Agents Chemother 54: 2987-93 (2010)
Checked by Author Article DOI: 10.1128/AAC.00198-10 BindingDB Entry DOI: 10.7270/Q2PK0GF9 |
More data for this Ligand-Target Pair | |
Geranylgeranyl pyrophosphate synthase
(Homo sapiens (Human)) | BDBM25259
(3-(decyloxy)-1-(2-hydrogen phosphonato-2-phosphono...)Show SMILES CCCCCCCCCCOc1ccc[n+](CC(P(O)(O)=O)P(O)([O-])=O)c1 Show InChI InChI=1S/C17H31NO7P2/c1-2-3-4-5-6-7-8-9-13-25-16-11-10-12-18(14-16)15-17(26(19,20)21)27(22,23)24/h10-12,14,17H,2-9,13,15H2,1H3,(H3-,19,20,21,22,23,24) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
MCE PC cid PC sid UniChem
Similars
| Article PubMed
| 6.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Immunology
Curated by ChEMBL
| Assay Description Inhibition of human GGPPS |
Antimicrob Agents Chemother 54: 2987-93 (2010)
Checked by Author Article DOI: 10.1128/AAC.00198-10 BindingDB Entry DOI: 10.7270/Q2PK0GF9 |
More data for this Ligand-Target Pair | |
Geranylgeranyl pyrophosphate synthase
(Homo sapiens (Human)) | BDBM50336505
(2-(methyl(octyl)amino)ethane-1,1-diyldiphosphonic ...)Show InChI InChI=1S/C11H27NO6P2/c1-3-4-5-6-7-8-9-12(2)10-11(19(13,14)15)20(16,17)18/h11H,3-10H2,1-2H3,(H2,13,14,15)(H2,16,17,18) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 1.20E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Immunology
Curated by ChEMBL
| Assay Description Inhibition of human GGPPS |
Antimicrob Agents Chemother 54: 2987-93 (2010)
Checked by Author Article DOI: 10.1128/AAC.00198-10 BindingDB Entry DOI: 10.7270/Q2PK0GF9 |
More data for this Ligand-Target Pair | |
Geranylgeranyl pyrophosphate synthase
(Homo sapiens (Human)) | BDBM12576
(Bisphosphonate 1 | CHEMBL923 | JMC515594 Compound ...)Show InChI InChI=1S/C7H11NO7P2/c9-7(16(10,11)12,17(13,14)15)4-6-2-1-3-8-5-6/h1-3,5,9H,4H2,(H2,10,11,12)(H2,13,14,15) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| 8.30E+6 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Immunology
Curated by ChEMBL
| Assay Description Inhibition of human GGPPS |
Antimicrob Agents Chemother 54: 2987-93 (2010)
Checked by Author Article DOI: 10.1128/AAC.00198-10 BindingDB Entry DOI: 10.7270/Q2PK0GF9 |
More data for this Ligand-Target Pair | |
Geranylgeranyl pyrophosphate synthase
(Homo sapiens (Human)) | BDBM50336506
(2-(decyl(methyl)amino)ethane-1,1-diyldiphosphonic ...)Show InChI InChI=1S/C13H31NO6P2/c1-3-4-5-6-7-8-9-10-11-14(2)12-13(21(15,16)17)22(18,19)20/h13H,3-12H2,1-2H3,(H2,15,16,17)(H2,18,19,20) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.20E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Immunology
Curated by ChEMBL
| Assay Description Inhibition of human GGPPS |
Antimicrob Agents Chemother 54: 2987-93 (2010)
Checked by Author Article DOI: 10.1128/AAC.00198-10 BindingDB Entry DOI: 10.7270/Q2PK0GF9 |
More data for this Ligand-Target Pair | |
Geranylgeranyl pyrophosphate synthase
(Homo sapiens (Human)) | BDBM25259
(3-(decyloxy)-1-(2-hydrogen phosphonato-2-phosphono...)Show SMILES CCCCCCCCCCOc1ccc[n+](CC(P(O)(O)=O)P(O)([O-])=O)c1 Show InChI InChI=1S/C17H31NO7P2/c1-2-3-4-5-6-7-8-9-13-25-16-11-10-12-18(14-16)15-17(26(19,20)21)27(22,23)24/h10-12,14,17H,2-9,13,15H2,1H3,(H3-,19,20,21,22,23,24) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
MCE PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.50E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Immunology
Curated by ChEMBL
| Assay Description Inhibition of human GGPPS |
Antimicrob Agents Chemother 54: 2987-93 (2010)
Checked by Author Article DOI: 10.1128/AAC.00198-10 BindingDB Entry DOI: 10.7270/Q2PK0GF9 |
More data for this Ligand-Target Pair | |
Geranylgeranyl pyrophosphate synthase
(Homo sapiens (Human)) | BDBM50336505
(2-(methyl(octyl)amino)ethane-1,1-diyldiphosphonic ...)Show InChI InChI=1S/C11H27NO6P2/c1-3-4-5-6-7-8-9-12(2)10-11(19(13,14)15)20(16,17)18/h11H,3-10H2,1-2H3,(H2,13,14,15)(H2,16,17,18) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 4.40E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Immunology
Curated by ChEMBL
| Assay Description Inhibition of human GGPPS |
Antimicrob Agents Chemother 54: 2987-93 (2010)
Checked by Author Article DOI: 10.1128/AAC.00198-10 BindingDB Entry DOI: 10.7270/Q2PK0GF9 |
More data for this Ligand-Target Pair | |
Geranylgeranyl pyrophosphate synthase
(Homo sapiens (Human)) | BDBM12576
(Bisphosphonate 1 | CHEMBL923 | JMC515594 Compound ...)Show InChI InChI=1S/C7H11NO7P2/c9-7(16(10,11)12,17(13,14)15)4-6-2-1-3-8-5-6/h1-3,5,9H,4H2,(H2,10,11,12)(H2,13,14,15) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 3.00E+8 | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Immunology
Curated by ChEMBL
| Assay Description Inhibition of human GGPPS |
Antimicrob Agents Chemother 54: 2987-93 (2010)
Checked by Author Article DOI: 10.1128/AAC.00198-10 BindingDB Entry DOI: 10.7270/Q2PK0GF9 |
More data for this Ligand-Target Pair | |