Found 64 hits Enz. Inhib. hit(s) with all data for entry = 50032999 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Carbonic anhydrase 5A, mitochondrial
(Homo sapiens (Human)) | BDBM50337754
((Z)-5-(((1R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]hepta...)Show SMILES Cn1nc(sc1=NS(=O)(=O)C[C@@]12CCC(CC1=O)C2(C)C)S(N)(=O)=O |r,w:6.7| Show InChI InChI=1S/C13H20N4O5S3/c1-12(2)8-4-5-13(12,9(18)6-8)7-24(19,20)16-10-17(3)15-11(23-10)25(14,21)22/h8H,4-7H2,1-3H3,(H2,14,21,22)/t8?,13-/m0/s1 | Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 5.90 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Firenze
Curated by ChEMBL
| Assay Description Inhibition of human recombinant CA5A mitochondrial isoform by stopped-flow CO2 hydration assay |
Bioorg Med Chem Lett 21: 1334-7 (2011)
Article DOI: 10.1016/j.bmcl.2011.01.050 BindingDB Entry DOI: 10.7270/Q2930TF6 |
More data for this Ligand-Target Pair | |
Carbonic anhydrase 5B, mitochondrial
(Homo sapiens (Human)) | BDBM50337755
(5-(((1S)-7,7-dimethyl-2-oxobicyclo[2.2.1]heptan-1-...)Show SMILES Cn1nc(sc1=NS(=O)(=O)C[C@]12CCC(CC1=O)C2(C)C)S(N)(=O)=O |r,w:6.7| Show InChI InChI=1S/C13H20N4O5S3/c1-12(2)8-4-5-13(12,9(18)6-8)7-24(19,20)16-10-17(3)15-11(23-10)25(14,21)22/h8H,4-7H2,1-3H3,(H2,14,21,22)/t8?,13-/m1/s1 | Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 7.30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Firenze
Curated by ChEMBL
| Assay Description Inhibition of human recombinant CA5B mitochondrial isoform by stopped-flow CO2 hydration assay |
Bioorg Med Chem Lett 21: 1334-7 (2011)
Article DOI: 10.1016/j.bmcl.2011.01.050 BindingDB Entry DOI: 10.7270/Q2930TF6 |
More data for this Ligand-Target Pair | |
Carbonic anhydrase 5B, mitochondrial
(Homo sapiens (Human)) | BDBM50337754
((Z)-5-(((1R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]hepta...)Show SMILES Cn1nc(sc1=NS(=O)(=O)C[C@@]12CCC(CC1=O)C2(C)C)S(N)(=O)=O |r,w:6.7| Show InChI InChI=1S/C13H20N4O5S3/c1-12(2)8-4-5-13(12,9(18)6-8)7-24(19,20)16-10-17(3)15-11(23-10)25(14,21)22/h8H,4-7H2,1-3H3,(H2,14,21,22)/t8?,13-/m0/s1 | Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 7.80 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Firenze
Curated by ChEMBL
| Assay Description Inhibition of human recombinant CA5B mitochondrial isoform by stopped-flow CO2 hydration assay |
Bioorg Med Chem Lett 21: 1334-7 (2011)
Article DOI: 10.1016/j.bmcl.2011.01.050 BindingDB Entry DOI: 10.7270/Q2930TF6 |
More data for this Ligand-Target Pair | |
Carbonic anhydrase 2
(Homo sapiens (Human)) | BDBM10882
(6-ethoxy-1,3-benzothiazole-2-sulfonamide | CHEMBL1...)Show InChI InChI=1S/C9H10N2O3S2/c1-2-14-6-3-4-7-8(5-6)15-9(11-7)16(10,12)13/h3-5H,2H2,1H3,(H2,10,12,13) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
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| MMDB PDB Article PubMed
| 8 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Firenze
Curated by ChEMBL
| Assay Description Inhibition of human recombinant CA2 cytosolic isoform by stopped-flow CO2 hydration assay |
Bioorg Med Chem Lett 21: 1334-7 (2011)
Article DOI: 10.1016/j.bmcl.2011.01.050 BindingDB Entry DOI: 10.7270/Q2930TF6 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Carbonic anhydrase 2
(Homo sapiens (Human)) | BDBM10887
(Sulfamate 7 | Topiramate (TPM) | US11535599, Examp...)Show SMILES CC1(C)O[C@@H]2CO[C@@]3(COS(N)(=O)=O)OC(C)(C)O[C@H]3[C@@H]2O1 |r| Show InChI InChI=1S/C12H21NO8S/c1-10(2)18-7-5-16-12(6-17-22(13,14)15)9(8(7)19-10)20-11(3,4)21-12/h7-9H,5-6H2,1-4H3,(H2,13,14,15)/t7-,8-,9+,12+/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
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| DrugBank PDB Article PubMed
| 10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Firenze
Curated by ChEMBL
| Assay Description Inhibition of human recombinant CA2 cytosolic isoform by stopped-flow CO2 hydration assay |
Bioorg Med Chem Lett 21: 1334-7 (2011)
Article DOI: 10.1016/j.bmcl.2011.01.050 BindingDB Entry DOI: 10.7270/Q2930TF6 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Carbonic anhydrase 2
(Homo sapiens (Human)) | BDBM10880
(AZA | AZA2 | AZM acetazolamide | Acerazolamide, AA...)Show InChI InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
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| DrugBank MMDB PDB Article PubMed
| 12 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Firenze
Curated by ChEMBL
| Assay Description Inhibition of human recombinant CA2 cytosolic isoform by stopped-flow CO2 hydration assay |
Bioorg Med Chem Lett 21: 1334-7 (2011)
Article DOI: 10.1016/j.bmcl.2011.01.050 BindingDB Entry DOI: 10.7270/Q2930TF6 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Carbonic anhydrase 2
(Homo sapiens (Human)) | BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)Show InChI InChI=1S/C5H8N4O3S2/c1-3(10)7-4-9(2)8-5(13-4)14(6,11)12/h1-2H3,(H2,6,11,12) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
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| PDB Article PubMed
| 14 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Firenze
Curated by ChEMBL
| Assay Description Inhibition of human recombinant CA2 cytosolic isoform by stopped-flow CO2 hydration assay |
Bioorg Med Chem Lett 21: 1334-7 (2011)
Article DOI: 10.1016/j.bmcl.2011.01.050 BindingDB Entry DOI: 10.7270/Q2930TF6 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Carbonic anhydrase 5A, mitochondrial
(Homo sapiens (Human)) | BDBM50337748
(4-((((1R)-7,7-dimethyl-2-oxobicyclo[2.2.1]heptan-1...)Show SMILES CC1(C)C2CC[C@]1(CS(=O)(=O)NCc1ccc(cc1)S(N)(=O)=O)C(=O)C2 |r| Show InChI InChI=1S/C17H24N2O5S2/c1-16(2)13-7-8-17(16,15(20)9-13)11-25(21,22)19-10-12-3-5-14(6-4-12)26(18,23)24/h3-6,13,19H,7-11H2,1-2H3,(H2,18,23,24)/t13?,17-/m0/s1 | Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
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CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 16.6 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Firenze
Curated by ChEMBL
| Assay Description Inhibition of human recombinant CA5A mitochondrial isoform by stopped-flow CO2 hydration assay |
Bioorg Med Chem Lett 21: 1334-7 (2011)
Article DOI: 10.1016/j.bmcl.2011.01.050 BindingDB Entry DOI: 10.7270/Q2930TF6 |
More data for this Ligand-Target Pair | |
Carbonic anhydrase 5A, mitochondrial
(Homo sapiens (Human)) | BDBM50337746
(4-(((1R)-7,7-dimethyl-2-oxobicyclo[2.2.1]heptan-1-...)Show SMILES CC1(C)C2CC[C@]1(CS(=O)(=O)Nc1ccc(cc1)S(N)(=O)=O)C(=O)C2 |r| Show InChI InChI=1S/C16H22N2O5S2/c1-15(2)11-7-8-16(15,14(19)9-11)10-24(20,21)18-12-3-5-13(6-4-12)25(17,22)23/h3-6,11,18H,7-10H2,1-2H3,(H2,17,22,23)/t11?,16-/m0/s1 | Reactome pathway KEGG
UniProtKB/SwissProt
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CHEMBL PC cid PC sid UniChem
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| Article PubMed
| 17.1 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Firenze
Curated by ChEMBL
| Assay Description Inhibition of human recombinant CA5A mitochondrial isoform by stopped-flow CO2 hydration assay |
Bioorg Med Chem Lett 21: 1334-7 (2011)
Article DOI: 10.1016/j.bmcl.2011.01.050 BindingDB Entry DOI: 10.7270/Q2930TF6 |
More data for this Ligand-Target Pair | |
Carbonic anhydrase 5B, mitochondrial
(Homo sapiens (Human)) | BDBM10882
(6-ethoxy-1,3-benzothiazole-2-sulfonamide | CHEMBL1...)Show InChI InChI=1S/C9H10N2O3S2/c1-2-14-6-3-4-7-8(5-6)15-9(11-7)16(10,12)13/h3-5H,2H2,1H3,(H2,10,12,13) | Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
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CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| 19 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Firenze
Curated by ChEMBL
| Assay Description Inhibition of human recombinant CA5B mitochondrial isoform by stopped-flow CO2 hydration assay |
Bioorg Med Chem Lett 21: 1334-7 (2011)
Article DOI: 10.1016/j.bmcl.2011.01.050 BindingDB Entry DOI: 10.7270/Q2930TF6 |
More data for this Ligand-Target Pair | |
Carbonic anhydrase 5A, mitochondrial
(Homo sapiens (Human)) | BDBM10888
(1,2-benzoxazol-3-ylmethanesulfonamide | CHEMBL750 ...)Show InChI InChI=1S/C8H8N2O3S/c9-14(11,12)5-7-6-3-1-2-4-8(6)13-10-7/h1-4H,5H2,(H2,9,11,12) | Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
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| DrugBank Article PubMed
| 20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Firenze
Curated by ChEMBL
| Assay Description Inhibition of human recombinant CA5A mitochondrial isoform by stopped-flow CO2 hydration assay |
Bioorg Med Chem Lett 21: 1334-7 (2011)
Article DOI: 10.1016/j.bmcl.2011.01.050 BindingDB Entry DOI: 10.7270/Q2930TF6 |
More data for this Ligand-Target Pair | |
Carbonic anhydrase 5B, mitochondrial
(Homo sapiens (Human)) | BDBM10883
(4,5-dichlorobenzene-1,3-disulfonamide | CHEMBL17 |...)Show InChI InChI=1S/C6H6Cl2N2O4S2/c7-4-1-3(15(9,11)12)2-5(6(4)8)16(10,13)14/h1-2H,(H2,9,11,12)(H2,10,13,14) | Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
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CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem
Patents
| Article PubMed
| 21 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Firenze
Curated by ChEMBL
| Assay Description Inhibition of human recombinant CA5B mitochondrial isoform by stopped-flow CO2 hydration assay |
Bioorg Med Chem Lett 21: 1334-7 (2011)
Article DOI: 10.1016/j.bmcl.2011.01.050 BindingDB Entry DOI: 10.7270/Q2930TF6 |
More data for this Ligand-Target Pair | |
Carbonic anhydrase 5A, mitochondrial
(Homo sapiens (Human)) | BDBM50337755
(5-(((1S)-7,7-dimethyl-2-oxobicyclo[2.2.1]heptan-1-...)Show SMILES Cn1nc(sc1=NS(=O)(=O)C[C@]12CCC(CC1=O)C2(C)C)S(N)(=O)=O |r,w:6.7| Show InChI InChI=1S/C13H20N4O5S3/c1-12(2)8-4-5-13(12,9(18)6-8)7-24(19,20)16-10-17(3)15-11(23-10)25(14,21)22/h8H,4-7H2,1-3H3,(H2,14,21,22)/t8?,13-/m1/s1 | Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 21 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Firenze
Curated by ChEMBL
| Assay Description Inhibition of human recombinant CA5A mitochondrial isoform by stopped-flow CO2 hydration assay |
Bioorg Med Chem Lett 21: 1334-7 (2011)
Article DOI: 10.1016/j.bmcl.2011.01.050 BindingDB Entry DOI: 10.7270/Q2930TF6 |
More data for this Ligand-Target Pair | |
Carbonic anhydrase 1
(Homo sapiens (Human)) | BDBM10882
(6-ethoxy-1,3-benzothiazole-2-sulfonamide | CHEMBL1...)Show InChI InChI=1S/C9H10N2O3S2/c1-2-14-6-3-4-7-8(5-6)15-9(11-7)16(10,12)13/h3-5H,2H2,1H3,(H2,10,12,13) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
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CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| 25 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Firenze
Curated by ChEMBL
| Assay Description Inhibition of human recombinant CA1 cytosolic isoform by stopped-flow CO2 hydration assay |
Bioorg Med Chem Lett 21: 1334-7 (2011)
Article DOI: 10.1016/j.bmcl.2011.01.050 BindingDB Entry DOI: 10.7270/Q2930TF6 |
More data for this Ligand-Target Pair | |
Carbonic anhydrase 5A, mitochondrial
(Homo sapiens (Human)) | BDBM10882
(6-ethoxy-1,3-benzothiazole-2-sulfonamide | CHEMBL1...)Show InChI InChI=1S/C9H10N2O3S2/c1-2-14-6-3-4-7-8(5-6)15-9(11-7)16(10,12)13/h3-5H,2H2,1H3,(H2,10,12,13) | Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
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CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem
Patents
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| Article PubMed
| 25 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Firenze
Curated by ChEMBL
| Assay Description Inhibition of human recombinant CA5A mitochondrial isoform by stopped-flow CO2 hydration assay |
Bioorg Med Chem Lett 21: 1334-7 (2011)
Article DOI: 10.1016/j.bmcl.2011.01.050 BindingDB Entry DOI: 10.7270/Q2930TF6 |
More data for this Ligand-Target Pair | |
Carbonic anhydrase 5B, mitochondrial
(Homo sapiens (Human)) | BDBM50337746
(4-(((1R)-7,7-dimethyl-2-oxobicyclo[2.2.1]heptan-1-...)Show SMILES CC1(C)C2CC[C@]1(CS(=O)(=O)Nc1ccc(cc1)S(N)(=O)=O)C(=O)C2 |r| Show InChI InChI=1S/C16H22N2O5S2/c1-15(2)11-7-8-16(15,14(19)9-11)10-24(20,21)18-12-3-5-13(6-4-12)25(17,22)23/h3-6,11,18H,7-10H2,1-2H3,(H2,17,22,23)/t11?,16-/m0/s1 | Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
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CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 26.4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Firenze
Curated by ChEMBL
| Assay Description Inhibition of human recombinant CA5B mitochondrial isoform by stopped-flow CO2 hydration assay |
Bioorg Med Chem Lett 21: 1334-7 (2011)
Article DOI: 10.1016/j.bmcl.2011.01.050 BindingDB Entry DOI: 10.7270/Q2930TF6 |
More data for this Ligand-Target Pair | |
Carbonic anhydrase 5A, mitochondrial
(Homo sapiens (Human)) | BDBM50337749
(4-((((1S)-7,7-dimethyl-2-oxobicyclo[2.2.1]heptan-1...)Show SMILES CC1(C)C2CC[C@@]1(CS(=O)(=O)NCc1ccc(cc1)S(N)(=O)=O)C(=O)C2 |r| Show InChI InChI=1S/C17H24N2O5S2/c1-16(2)13-7-8-17(16,15(20)9-13)11-25(21,22)19-10-12-3-5-14(6-4-12)26(18,23)24/h3-6,13,19H,7-11H2,1-2H3,(H2,18,23,24)/t13?,17-/m1/s1 | Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
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CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 27.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Firenze
Curated by ChEMBL
| Assay Description Inhibition of human recombinant CA5A mitochondrial isoform by stopped-flow CO2 hydration assay |
Bioorg Med Chem Lett 21: 1334-7 (2011)
Article DOI: 10.1016/j.bmcl.2011.01.050 BindingDB Entry DOI: 10.7270/Q2930TF6 |
More data for this Ligand-Target Pair | |
Carbonic anhydrase 5B, mitochondrial
(Homo sapiens (Human)) | BDBM50337747
(4-(((1S)-7,7-dimethyl-2-oxobicyclo[2.2.1]heptan-1-...)Show SMILES CC1(C)C2CC[C@@]1(CS(=O)(=O)Nc1ccc(cc1)S(N)(=O)=O)C(=O)C2 |r| Show InChI InChI=1S/C16H22N2O5S2/c1-15(2)11-7-8-16(15,14(19)9-11)10-24(20,21)18-12-3-5-13(6-4-12)25(17,22)23/h3-6,11,18H,7-10H2,1-2H3,(H2,17,22,23)/t11?,16-/m1/s1 | Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
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CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Firenze
Curated by ChEMBL
| Assay Description Inhibition of human recombinant CA5B mitochondrial isoform by stopped-flow CO2 hydration assay |
Bioorg Med Chem Lett 21: 1334-7 (2011)
Article DOI: 10.1016/j.bmcl.2011.01.050 BindingDB Entry DOI: 10.7270/Q2930TF6 |
More data for this Ligand-Target Pair | |
Carbonic anhydrase 5B, mitochondrial
(Homo sapiens (Human)) | BDBM10887
(Sulfamate 7 | Topiramate (TPM) | US11535599, Examp...)Show SMILES CC1(C)O[C@@H]2CO[C@@]3(COS(N)(=O)=O)OC(C)(C)O[C@H]3[C@@H]2O1 |r| Show InChI InChI=1S/C12H21NO8S/c1-10(2)18-7-5-16-12(6-17-22(13,14)15)9(8(7)19-10)20-11(3,4)21-12/h7-9H,5-6H2,1-4H3,(H2,13,14,15)/t7-,8-,9+,12+/m1/s1 | Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
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Patents
Similars
| Article PubMed
| 30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Firenze
Curated by ChEMBL
| Assay Description Inhibition of human recombinant CA5B mitochondrial isoform by stopped-flow CO2 hydration assay |
Bioorg Med Chem Lett 21: 1334-7 (2011)
Article DOI: 10.1016/j.bmcl.2011.01.050 BindingDB Entry DOI: 10.7270/Q2930TF6 |
More data for this Ligand-Target Pair | |
Carbonic anhydrase 5A, mitochondrial
(Homo sapiens (Human)) | BDBM50337751
(4-(2-(((1S)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan...)Show SMILES CC1(C)C2CC[C@@]1(CS(=O)(=O)NCCc1ccc(cc1)S(N)(=O)=O)C(=O)C2 |r| Show InChI InChI=1S/C18H26N2O5S2/c1-17(2)14-7-9-18(17,16(21)11-14)12-26(22,23)20-10-8-13-3-5-15(6-4-13)27(19,24)25/h3-6,14,20H,7-12H2,1-2H3,(H2,19,24,25)/t14?,18-/m1/s1 | Reactome pathway KEGG
UniProtKB/SwissProt
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| Article PubMed
| 33.2 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Firenze
Curated by ChEMBL
| Assay Description Inhibition of human recombinant CA5A mitochondrial isoform by stopped-flow CO2 hydration assay |
Bioorg Med Chem Lett 21: 1334-7 (2011)
Article DOI: 10.1016/j.bmcl.2011.01.050 BindingDB Entry DOI: 10.7270/Q2930TF6 |
More data for this Ligand-Target Pair | |
Carbonic anhydrase 2
(Homo sapiens (Human)) | BDBM10888
(1,2-benzoxazol-3-ylmethanesulfonamide | CHEMBL750 ...)Show InChI InChI=1S/C8H8N2O3S/c9-14(11,12)5-7-6-3-1-2-4-8(6)13-10-7/h1-4H,5H2,(H2,9,11,12) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
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| DrugBank Article PubMed
| 35 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Firenze
Curated by ChEMBL
| Assay Description Inhibition of human recombinant CA2 cytosolic isoform by stopped-flow CO2 hydration assay |
Bioorg Med Chem Lett 21: 1334-7 (2011)
Article DOI: 10.1016/j.bmcl.2011.01.050 BindingDB Entry DOI: 10.7270/Q2930TF6 |
More data for this Ligand-Target Pair | |
Carbonic anhydrase 5A, mitochondrial
(Homo sapiens (Human)) | BDBM50337752
(3-(((1R)-7,7-dimethyl-2-oxobicyclo[2.2.1]heptan-1-...)Show SMILES CC1(C)C2CC[C@]1(CS(=O)(=O)Nc1cccc(c1)S(N)(=O)=O)C(=O)C2 |r| Show InChI InChI=1S/C16H22N2O5S2/c1-15(2)11-6-7-16(15,14(19)8-11)10-24(20,21)18-12-4-3-5-13(9-12)25(17,22)23/h3-5,9,11,18H,6-8,10H2,1-2H3,(H2,17,22,23)/t11?,16-/m0/s1 | Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
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CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 35.3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Firenze
Curated by ChEMBL
| Assay Description Inhibition of human recombinant CA5A mitochondrial isoform by stopped-flow CO2 hydration assay |
Bioorg Med Chem Lett 21: 1334-7 (2011)
Article DOI: 10.1016/j.bmcl.2011.01.050 BindingDB Entry DOI: 10.7270/Q2930TF6 |
More data for this Ligand-Target Pair | |
Carbonic anhydrase 5B, mitochondrial
(Homo sapiens (Human)) | BDBM50337750
(4-(2-(((1R)-7,7-dimethyl-2-oxobicyclo[2.2.1]heptan...)Show SMILES CC1(C)C2CC[C@]1(CS(=O)(=O)NCCc1ccc(cc1)S(N)(=O)=O)C(=O)C2 |r| Show InChI InChI=1S/C18H26N2O5S2/c1-17(2)14-7-9-18(17,16(21)11-14)12-26(22,23)20-10-8-13-3-5-15(6-4-13)27(19,24)25/h3-6,14,20H,7-12H2,1-2H3,(H2,19,24,25)/t14?,18-/m0/s1 | Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
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CHEMBL PC cid PC sid UniChem
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| Article PubMed
| 36.2 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Firenze
Curated by ChEMBL
| Assay Description Inhibition of human recombinant CA5B mitochondrial isoform by stopped-flow CO2 hydration assay |
Bioorg Med Chem Lett 21: 1334-7 (2011)
Article DOI: 10.1016/j.bmcl.2011.01.050 BindingDB Entry DOI: 10.7270/Q2930TF6 |
More data for this Ligand-Target Pair | |
Carbonic anhydrase 2
(Homo sapiens (Human)) | BDBM10883
(4,5-dichlorobenzene-1,3-disulfonamide | CHEMBL17 |...)Show InChI InChI=1S/C6H6Cl2N2O4S2/c7-4-1-3(15(9,11)12)2-5(6(4)8)16(10,13)14/h1-2H,(H2,9,11,12)(H2,10,13,14) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
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CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem
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| DrugBank MMDB PDB Article PubMed
| 38 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Firenze
Curated by ChEMBL
| Assay Description Inhibition of human recombinant CA2 cytosolic isoform by stopped-flow CO2 hydration assay |
Bioorg Med Chem Lett 21: 1334-7 (2011)
Article DOI: 10.1016/j.bmcl.2011.01.050 BindingDB Entry DOI: 10.7270/Q2930TF6 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Carbonic anhydrase 5B, mitochondrial
(Homo sapiens (Human)) | BDBM50337752
(3-(((1R)-7,7-dimethyl-2-oxobicyclo[2.2.1]heptan-1-...)Show SMILES CC1(C)C2CC[C@]1(CS(=O)(=O)Nc1cccc(c1)S(N)(=O)=O)C(=O)C2 |r| Show InChI InChI=1S/C16H22N2O5S2/c1-15(2)11-6-7-16(15,14(19)8-11)10-24(20,21)18-12-4-3-5-13(9-12)25(17,22)23/h3-5,9,11,18H,6-8,10H2,1-2H3,(H2,17,22,23)/t11?,16-/m0/s1 | Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
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CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 38.4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Firenze
Curated by ChEMBL
| Assay Description Inhibition of human recombinant CA5B mitochondrial isoform by stopped-flow CO2 hydration assay |
Bioorg Med Chem Lett 21: 1334-7 (2011)
Article DOI: 10.1016/j.bmcl.2011.01.050 BindingDB Entry DOI: 10.7270/Q2930TF6 |
More data for this Ligand-Target Pair | |
Carbonic anhydrase 5B, mitochondrial
(Homo sapiens (Human)) | BDBM50337748
(4-((((1R)-7,7-dimethyl-2-oxobicyclo[2.2.1]heptan-1...)Show SMILES CC1(C)C2CC[C@]1(CS(=O)(=O)NCc1ccc(cc1)S(N)(=O)=O)C(=O)C2 |r| Show InChI InChI=1S/C17H24N2O5S2/c1-16(2)13-7-8-17(16,15(20)9-13)11-25(21,22)19-10-12-3-5-14(6-4-12)26(18,23)24/h3-6,13,19H,7-11H2,1-2H3,(H2,18,23,24)/t13?,17-/m0/s1 | Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
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CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 40.3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Firenze
Curated by ChEMBL
| Assay Description Inhibition of human recombinant CA5B mitochondrial isoform by stopped-flow CO2 hydration assay |
Bioorg Med Chem Lett 21: 1334-7 (2011)
Article DOI: 10.1016/j.bmcl.2011.01.050 BindingDB Entry DOI: 10.7270/Q2930TF6 |
More data for this Ligand-Target Pair | |
Carbonic anhydrase 5B, mitochondrial
(Homo sapiens (Human)) | BDBM50337753
(3-(((1S)-7,7-dimethyl-2-oxobicyclo[2.2.1]heptan-1-...)Show SMILES CC1(C)C2CC[C@@]1(CS(=O)(=O)Nc1cccc(c1)S(N)(=O)=O)C(=O)C2 |r| Show InChI InChI=1S/C16H22N2O5S2/c1-15(2)11-6-7-16(15,14(19)8-11)10-24(20,21)18-12-4-3-5-13(9-12)25(17,22)23/h3-5,9,11,18H,6-8,10H2,1-2H3,(H2,17,22,23)/t11?,16-/m1/s1 | Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
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CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 44.3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Firenze
Curated by ChEMBL
| Assay Description Inhibition of human recombinant CA5B mitochondrial isoform by stopped-flow CO2 hydration assay |
Bioorg Med Chem Lett 21: 1334-7 (2011)
Article DOI: 10.1016/j.bmcl.2011.01.050 BindingDB Entry DOI: 10.7270/Q2930TF6 |
More data for this Ligand-Target Pair | |
Carbonic anhydrase 5A, mitochondrial
(Homo sapiens (Human)) | BDBM50337753
(3-(((1S)-7,7-dimethyl-2-oxobicyclo[2.2.1]heptan-1-...)Show SMILES CC1(C)C2CC[C@@]1(CS(=O)(=O)Nc1cccc(c1)S(N)(=O)=O)C(=O)C2 |r| Show InChI InChI=1S/C16H22N2O5S2/c1-15(2)11-6-7-16(15,14(19)8-11)10-24(20,21)18-12-4-3-5-13(9-12)25(17,22)23/h3-5,9,11,18H,6-8,10H2,1-2H3,(H2,17,22,23)/t11?,16-/m1/s1 | Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
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CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 48.7 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Firenze
Curated by ChEMBL
| Assay Description Inhibition of human recombinant CA5A mitochondrial isoform by stopped-flow CO2 hydration assay |
Bioorg Med Chem Lett 21: 1334-7 (2011)
Article DOI: 10.1016/j.bmcl.2011.01.050 BindingDB Entry DOI: 10.7270/Q2930TF6 |
More data for this Ligand-Target Pair | |
Carbonic anhydrase 1
(Homo sapiens (Human)) | BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)Show InChI InChI=1S/C5H8N4O3S2/c1-3(10)7-4-9(2)8-5(13-4)14(6,11)12/h1-2H3,(H2,6,11,12) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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| PDB Article PubMed
| 50 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Firenze
Curated by ChEMBL
| Assay Description Inhibition of human recombinant CA1 cytosolic isoform by stopped-flow CO2 hydration assay |
Bioorg Med Chem Lett 21: 1334-7 (2011)
Article DOI: 10.1016/j.bmcl.2011.01.050 BindingDB Entry DOI: 10.7270/Q2930TF6 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Carbonic anhydrase 5B, mitochondrial
(Homo sapiens (Human)) | BDBM10880
(AZA | AZA2 | AZM acetazolamide | Acerazolamide, AA...)Show InChI InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9) | Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
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CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem
Patents
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| Article PubMed
| 54 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Firenze
Curated by ChEMBL
| Assay Description Inhibition of human recombinant CA5B mitochondrial isoform by stopped-flow CO2 hydration assay |
Bioorg Med Chem Lett 21: 1334-7 (2011)
Article DOI: 10.1016/j.bmcl.2011.01.050 BindingDB Entry DOI: 10.7270/Q2930TF6 |
More data for this Ligand-Target Pair | |
Carbonic anhydrase 5B, mitochondrial
(Homo sapiens (Human)) | BDBM50337751
(4-(2-(((1S)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan...)Show SMILES CC1(C)C2CC[C@@]1(CS(=O)(=O)NCCc1ccc(cc1)S(N)(=O)=O)C(=O)C2 |r| Show InChI InChI=1S/C18H26N2O5S2/c1-17(2)14-7-9-18(17,16(21)11-14)12-26(22,23)20-10-8-13-3-5-15(6-4-13)27(19,24)25/h3-6,14,20H,7-12H2,1-2H3,(H2,19,24,25)/t14?,18-/m1/s1 | Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
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CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 54.1 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Firenze
Curated by ChEMBL
| Assay Description Inhibition of human recombinant CA5B mitochondrial isoform by stopped-flow CO2 hydration assay |
Bioorg Med Chem Lett 21: 1334-7 (2011)
Article DOI: 10.1016/j.bmcl.2011.01.050 BindingDB Entry DOI: 10.7270/Q2930TF6 |
More data for this Ligand-Target Pair | |
Carbonic anhydrase 1
(Homo sapiens (Human)) | BDBM10888
(1,2-benzoxazol-3-ylmethanesulfonamide | CHEMBL750 ...)Show InChI InChI=1S/C8H8N2O3S/c9-14(11,12)5-7-6-3-1-2-4-8(6)13-10-7/h1-4H,5H2,(H2,9,11,12) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
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CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem
Patents
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| DrugBank Article PubMed
| 56 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Firenze
Curated by ChEMBL
| Assay Description Inhibition of human recombinant CA1 cytosolic isoform by stopped-flow CO2 hydration assay |
Bioorg Med Chem Lett 21: 1334-7 (2011)
Article DOI: 10.1016/j.bmcl.2011.01.050 BindingDB Entry DOI: 10.7270/Q2930TF6 |
More data for this Ligand-Target Pair | |
Carbonic anhydrase 5B, mitochondrial
(Homo sapiens (Human)) | BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)Show InChI InChI=1S/C5H8N4O3S2/c1-3(10)7-4-9(2)8-5(13-4)14(6,11)12/h1-2H3,(H2,6,11,12) | Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
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CHEMBL PC cid PC sid PDB UniChem
Patents
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| Article PubMed
| 62 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Firenze
Curated by ChEMBL
| Assay Description Inhibition of human recombinant CA5B mitochondrial isoform by stopped-flow CO2 hydration assay |
Bioorg Med Chem Lett 21: 1334-7 (2011)
Article DOI: 10.1016/j.bmcl.2011.01.050 BindingDB Entry DOI: 10.7270/Q2930TF6 |
More data for this Ligand-Target Pair | |
Carbonic anhydrase 5A, mitochondrial
(Homo sapiens (Human)) | BDBM10887
(Sulfamate 7 | Topiramate (TPM) | US11535599, Examp...)Show SMILES CC1(C)O[C@@H]2CO[C@@]3(COS(N)(=O)=O)OC(C)(C)O[C@H]3[C@@H]2O1 |r| Show InChI InChI=1S/C12H21NO8S/c1-10(2)18-7-5-16-12(6-17-22(13,14)15)9(8(7)19-10)20-11(3,4)21-12/h7-9H,5-6H2,1-4H3,(H2,13,14,15)/t7-,8-,9+,12+/m1/s1 | Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
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DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| 63 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Firenze
Curated by ChEMBL
| Assay Description Inhibition of human recombinant CA5A mitochondrial isoform by stopped-flow CO2 hydration assay |
Bioorg Med Chem Lett 21: 1334-7 (2011)
Article DOI: 10.1016/j.bmcl.2011.01.050 BindingDB Entry DOI: 10.7270/Q2930TF6 |
More data for this Ligand-Target Pair | |
Carbonic anhydrase 5A, mitochondrial
(Homo sapiens (Human)) | BDBM10880
(AZA | AZA2 | AZM acetazolamide | Acerazolamide, AA...)Show InChI InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9) | Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
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CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| 63 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Firenze
Curated by ChEMBL
| Assay Description Inhibition of human recombinant CA5A mitochondrial isoform by stopped-flow CO2 hydration assay |
Bioorg Med Chem Lett 21: 1334-7 (2011)
Article DOI: 10.1016/j.bmcl.2011.01.050 BindingDB Entry DOI: 10.7270/Q2930TF6 |
More data for this Ligand-Target Pair | |
Carbonic anhydrase 5A, mitochondrial
(Homo sapiens (Human)) | BDBM50337750
(4-(2-(((1R)-7,7-dimethyl-2-oxobicyclo[2.2.1]heptan...)Show SMILES CC1(C)C2CC[C@]1(CS(=O)(=O)NCCc1ccc(cc1)S(N)(=O)=O)C(=O)C2 |r| Show InChI InChI=1S/C18H26N2O5S2/c1-17(2)14-7-9-18(17,16(21)11-14)12-26(22,23)20-10-8-13-3-5-15(6-4-13)27(19,24)25/h3-6,14,20H,7-12H2,1-2H3,(H2,19,24,25)/t14?,18-/m0/s1 | Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
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CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 64.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Firenze
Curated by ChEMBL
| Assay Description Inhibition of human recombinant CA5A mitochondrial isoform by stopped-flow CO2 hydration assay |
Bioorg Med Chem Lett 21: 1334-7 (2011)
Article DOI: 10.1016/j.bmcl.2011.01.050 BindingDB Entry DOI: 10.7270/Q2930TF6 |
More data for this Ligand-Target Pair | |
Carbonic anhydrase 5A, mitochondrial
(Homo sapiens (Human)) | BDBM10881
(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)Show InChI InChI=1S/C5H8N4O3S2/c1-3(10)7-4-9(2)8-5(13-4)14(6,11)12/h1-2H3,(H2,6,11,12) | Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
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CHEMBL PC cid PC sid PDB UniChem
Patents
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| Article PubMed
| 65 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Firenze
Curated by ChEMBL
| Assay Description Inhibition of human recombinant CA5A mitochondrial isoform by stopped-flow CO2 hydration assay |
Bioorg Med Chem Lett 21: 1334-7 (2011)
Article DOI: 10.1016/j.bmcl.2011.01.050 BindingDB Entry DOI: 10.7270/Q2930TF6 |
More data for this Ligand-Target Pair | |
Carbonic anhydrase 5B, mitochondrial
(Homo sapiens (Human)) | BDBM50337749
(4-((((1S)-7,7-dimethyl-2-oxobicyclo[2.2.1]heptan-1...)Show SMILES CC1(C)C2CC[C@@]1(CS(=O)(=O)NCc1ccc(cc1)S(N)(=O)=O)C(=O)C2 |r| Show InChI InChI=1S/C17H24N2O5S2/c1-16(2)13-7-8-17(16,15(20)9-13)11-25(21,22)19-10-12-3-5-14(6-4-12)26(18,23)24/h3-6,13,19H,7-11H2,1-2H3,(H2,18,23,24)/t13?,17-/m1/s1 | Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
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CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 67.3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Firenze
Curated by ChEMBL
| Assay Description Inhibition of human recombinant CA5B mitochondrial isoform by stopped-flow CO2 hydration assay |
Bioorg Med Chem Lett 21: 1334-7 (2011)
Article DOI: 10.1016/j.bmcl.2011.01.050 BindingDB Entry DOI: 10.7270/Q2930TF6 |
More data for this Ligand-Target Pair | |
Carbonic anhydrase 5A, mitochondrial
(Homo sapiens (Human)) | BDBM50337747
(4-(((1S)-7,7-dimethyl-2-oxobicyclo[2.2.1]heptan-1-...)Show SMILES CC1(C)C2CC[C@@]1(CS(=O)(=O)Nc1ccc(cc1)S(N)(=O)=O)C(=O)C2 |r| Show InChI InChI=1S/C16H22N2O5S2/c1-15(2)11-7-8-16(15,14(19)9-11)10-24(20,21)18-12-3-5-13(6-4-12)25(17,22)23/h3-6,11,18H,7-10H2,1-2H3,(H2,17,22,23)/t11?,16-/m1/s1 | Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
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CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 68.6 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Firenze
Curated by ChEMBL
| Assay Description Inhibition of human recombinant CA5A mitochondrial isoform by stopped-flow CO2 hydration assay |
Bioorg Med Chem Lett 21: 1334-7 (2011)
Article DOI: 10.1016/j.bmcl.2011.01.050 BindingDB Entry DOI: 10.7270/Q2930TF6 |
More data for this Ligand-Target Pair | |
Carbonic anhydrase 2
(Homo sapiens (Human)) | BDBM50337752
(3-(((1R)-7,7-dimethyl-2-oxobicyclo[2.2.1]heptan-1-...)Show SMILES CC1(C)C2CC[C@]1(CS(=O)(=O)Nc1cccc(c1)S(N)(=O)=O)C(=O)C2 |r| Show InChI InChI=1S/C16H22N2O5S2/c1-15(2)11-6-7-16(15,14(19)8-11)10-24(20,21)18-12-4-3-5-13(9-12)25(17,22)23/h3-5,9,11,18H,6-8,10H2,1-2H3,(H2,17,22,23)/t11?,16-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
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CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 78.9 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Firenze
Curated by ChEMBL
| Assay Description Inhibition of human recombinant CA2 cytosolic isoform by stopped-flow CO2 hydration assay |
Bioorg Med Chem Lett 21: 1334-7 (2011)
Article DOI: 10.1016/j.bmcl.2011.01.050 BindingDB Entry DOI: 10.7270/Q2930TF6 |
More data for this Ligand-Target Pair | |
Carbonic anhydrase 1
(Homo sapiens (Human)) | BDBM50337753
(3-(((1S)-7,7-dimethyl-2-oxobicyclo[2.2.1]heptan-1-...)Show SMILES CC1(C)C2CC[C@@]1(CS(=O)(=O)Nc1cccc(c1)S(N)(=O)=O)C(=O)C2 |r| Show InChI InChI=1S/C16H22N2O5S2/c1-15(2)11-6-7-16(15,14(19)8-11)10-24(20,21)18-12-4-3-5-13(9-12)25(17,22)23/h3-5,9,11,18H,6-8,10H2,1-2H3,(H2,17,22,23)/t11?,16-/m1/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
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CHEMBL PC cid PC sid UniChem
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| Article PubMed
| 81.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Firenze
Curated by ChEMBL
| Assay Description Inhibition of human recombinant CA1 cytosolic isoform by stopped-flow CO2 hydration assay |
Bioorg Med Chem Lett 21: 1334-7 (2011)
Article DOI: 10.1016/j.bmcl.2011.01.050 BindingDB Entry DOI: 10.7270/Q2930TF6 |
More data for this Ligand-Target Pair | |
Carbonic anhydrase 1
(Homo sapiens (Human)) | BDBM10880
(AZA | AZA2 | AZM acetazolamide | Acerazolamide, AA...)Show InChI InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
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| DrugBank PDB Article PubMed
| 250 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Firenze
Curated by ChEMBL
| Assay Description Inhibition of human recombinant CA1 cytosolic isoform by stopped-flow CO2 hydration assay |
Bioorg Med Chem Lett 21: 1334-7 (2011)
Article DOI: 10.1016/j.bmcl.2011.01.050 BindingDB Entry DOI: 10.7270/Q2930TF6 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Carbonic anhydrase 1
(Homo sapiens (Human)) | BDBM10887
(Sulfamate 7 | Topiramate (TPM) | US11535599, Examp...)Show SMILES CC1(C)O[C@@H]2CO[C@@]3(COS(N)(=O)=O)OC(C)(C)O[C@H]3[C@@H]2O1 |r| Show InChI InChI=1S/C12H21NO8S/c1-10(2)18-7-5-16-12(6-17-22(13,14)15)9(8(7)19-10)20-11(3,4)21-12/h7-9H,5-6H2,1-4H3,(H2,13,14,15)/t7-,8-,9+,12+/m1/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
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DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem
Patents
Similars
| MMDB PDB Article PubMed
| 250 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Firenze
Curated by ChEMBL
| Assay Description Inhibition of human recombinant CA1 cytosolic isoform by stopped-flow CO2 hydration assay |
Bioorg Med Chem Lett 21: 1334-7 (2011)
Article DOI: 10.1016/j.bmcl.2011.01.050 BindingDB Entry DOI: 10.7270/Q2930TF6 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Carbonic anhydrase 2
(Homo sapiens (Human)) | BDBM50337755
(5-(((1S)-7,7-dimethyl-2-oxobicyclo[2.2.1]heptan-1-...)Show SMILES Cn1nc(sc1=NS(=O)(=O)C[C@]12CCC(CC1=O)C2(C)C)S(N)(=O)=O |r,w:6.7| Show InChI InChI=1S/C13H20N4O5S3/c1-12(2)8-4-5-13(12,9(18)6-8)7-24(19,20)16-10-17(3)15-11(23-10)25(14,21)22/h8H,4-7H2,1-3H3,(H2,14,21,22)/t8?,13-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 398 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Firenze
Curated by ChEMBL
| Assay Description Inhibition of human recombinant CA2 cytosolic isoform by stopped-flow CO2 hydration assay |
Bioorg Med Chem Lett 21: 1334-7 (2011)
Article DOI: 10.1016/j.bmcl.2011.01.050 BindingDB Entry DOI: 10.7270/Q2930TF6 |
More data for this Ligand-Target Pair | |
Carbonic anhydrase 5A, mitochondrial
(Homo sapiens (Human)) | BDBM10883
(4,5-dichlorobenzene-1,3-disulfonamide | CHEMBL17 |...)Show InChI InChI=1S/C6H6Cl2N2O4S2/c7-4-1-3(15(9,11)12)2-5(6(4)8)16(10,13)14/h1-2H,(H2,9,11,12)(H2,10,13,14) | Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
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CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem
Patents
| Article PubMed
| 630 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Firenze
Curated by ChEMBL
| Assay Description Inhibition of human recombinant CA5A mitochondrial isoform by stopped-flow CO2 hydration assay |
Bioorg Med Chem Lett 21: 1334-7 (2011)
Article DOI: 10.1016/j.bmcl.2011.01.050 BindingDB Entry DOI: 10.7270/Q2930TF6 |
More data for this Ligand-Target Pair | |
Carbonic anhydrase 1
(Homo sapiens (Human)) | BDBM50337748
(4-((((1R)-7,7-dimethyl-2-oxobicyclo[2.2.1]heptan-1...)Show SMILES CC1(C)C2CC[C@]1(CS(=O)(=O)NCc1ccc(cc1)S(N)(=O)=O)C(=O)C2 |r| Show InChI InChI=1S/C17H24N2O5S2/c1-16(2)13-7-8-17(16,15(20)9-13)11-25(21,22)19-10-12-3-5-14(6-4-12)26(18,23)24/h3-6,13,19H,7-11H2,1-2H3,(H2,18,23,24)/t13?,17-/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
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CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 920 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Firenze
Curated by ChEMBL
| Assay Description Inhibition of human recombinant CA1 cytosolic isoform by stopped-flow CO2 hydration assay |
Bioorg Med Chem Lett 21: 1334-7 (2011)
Article DOI: 10.1016/j.bmcl.2011.01.050 BindingDB Entry DOI: 10.7270/Q2930TF6 |
More data for this Ligand-Target Pair | |
Carbonic anhydrase 2
(Homo sapiens (Human)) | BDBM50337750
(4-(2-(((1R)-7,7-dimethyl-2-oxobicyclo[2.2.1]heptan...)Show SMILES CC1(C)C2CC[C@]1(CS(=O)(=O)NCCc1ccc(cc1)S(N)(=O)=O)C(=O)C2 |r| Show InChI InChI=1S/C18H26N2O5S2/c1-17(2)14-7-9-18(17,16(21)11-14)12-26(22,23)20-10-8-13-3-5-15(6-4-13)27(19,24)25/h3-6,14,20H,7-12H2,1-2H3,(H2,19,24,25)/t14?,18-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
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CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 963 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Firenze
Curated by ChEMBL
| Assay Description Inhibition of human recombinant CA2 cytosolic isoform by stopped-flow CO2 hydration assay |
Bioorg Med Chem Lett 21: 1334-7 (2011)
Article DOI: 10.1016/j.bmcl.2011.01.050 BindingDB Entry DOI: 10.7270/Q2930TF6 |
More data for this Ligand-Target Pair | |
Carbonic anhydrase 1
(Homo sapiens (Human)) | BDBM50337749
(4-((((1S)-7,7-dimethyl-2-oxobicyclo[2.2.1]heptan-1...)Show SMILES CC1(C)C2CC[C@@]1(CS(=O)(=O)NCc1ccc(cc1)S(N)(=O)=O)C(=O)C2 |r| Show InChI InChI=1S/C17H24N2O5S2/c1-16(2)13-7-8-17(16,15(20)9-13)11-25(21,22)19-10-12-3-5-14(6-4-12)26(18,23)24/h3-6,13,19H,7-11H2,1-2H3,(H2,18,23,24)/t13?,17-/m1/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
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CHEMBL PC cid PC sid UniChem
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| Article PubMed
| 1.04E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Firenze
Curated by ChEMBL
| Assay Description Inhibition of human recombinant CA1 cytosolic isoform by stopped-flow CO2 hydration assay |
Bioorg Med Chem Lett 21: 1334-7 (2011)
Article DOI: 10.1016/j.bmcl.2011.01.050 BindingDB Entry DOI: 10.7270/Q2930TF6 |
More data for this Ligand-Target Pair | |
Carbonic anhydrase 2
(Homo sapiens (Human)) | BDBM50337747
(4-(((1S)-7,7-dimethyl-2-oxobicyclo[2.2.1]heptan-1-...)Show SMILES CC1(C)C2CC[C@@]1(CS(=O)(=O)Nc1ccc(cc1)S(N)(=O)=O)C(=O)C2 |r| Show InChI InChI=1S/C16H22N2O5S2/c1-15(2)11-7-8-16(15,14(19)9-11)10-24(20,21)18-12-3-5-13(6-4-12)25(17,22)23/h3-6,11,18H,7-10H2,1-2H3,(H2,17,22,23)/t11?,16-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
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CHEMBL PC cid PC sid UniChem
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| Article PubMed
| 1.17E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Firenze
Curated by ChEMBL
| Assay Description Inhibition of human recombinant CA2 cytosolic isoform by stopped-flow CO2 hydration assay |
Bioorg Med Chem Lett 21: 1334-7 (2011)
Article DOI: 10.1016/j.bmcl.2011.01.050 BindingDB Entry DOI: 10.7270/Q2930TF6 |
More data for this Ligand-Target Pair | 3D Structure (docked) |
Carbonic anhydrase 1
(Homo sapiens (Human)) | BDBM10883
(4,5-dichlorobenzene-1,3-disulfonamide | CHEMBL17 |...)Show InChI InChI=1S/C6H6Cl2N2O4S2/c7-4-1-3(15(9,11)12)2-5(6(4)8)16(10,13)14/h1-2H,(H2,9,11,12)(H2,10,13,14) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
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CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem
Patents
| DrugBank Article PubMed
| 1.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Firenze
Curated by ChEMBL
| Assay Description Inhibition of human recombinant CA1 cytosolic isoform by stopped-flow CO2 hydration assay |
Bioorg Med Chem Lett 21: 1334-7 (2011)
Article DOI: 10.1016/j.bmcl.2011.01.050 BindingDB Entry DOI: 10.7270/Q2930TF6 |
More data for this Ligand-Target Pair | |