BindingDB PrimarySearch

Found 5 hits Enz. Inhib. hit(s) with all data for entry = 50033974
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Histone deacetylase 4 (Homo sapiens (Human))	BDBM25164 (2,2,2-trifluoro-1-[5-({3-phenyl-5H,6H,7H,8H-imidaz...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	367	n/a	n/a	n/a	n/a	n/a	n/a
Drexel University Curated by ChEMBL					Assay Description Inhibition of human HDAC4 catalytic domain (residues Thr648-Thr1057) expressed in Escherichia coli BL21using fluorogenic substrate by fluorescence as...				Bioorg Med Chem Lett 21: 5854-8 (2011) Article DOI: 10.1016/j.bmcl.2011.07.100 BindingDB Entry DOI: 10.7270/Q2KS6RZR
Drexel University Curated by ChEMBL					More data for this Ligand-Target Pair
Histone deacetylase 8 (Homo sapiens (Human))	BDBM50354831 (CHEMBL1833976) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	370	n/a	n/a	n/a	n/a	n/a	n/a
Drexel University Curated by ChEMBL					Assay Description Inhibition of HDAC8				Bioorg Med Chem Lett 21: 5854-8 (2011) Article DOI: 10.1016/j.bmcl.2011.07.100 BindingDB Entry DOI: 10.7270/Q2KS6RZR
Drexel University Curated by ChEMBL					More data for this Ligand-Target Pair
Histone deacetylase 8 (Homo sapiens (Human))	BDBM50121062 (9,9,9-TRIFLUORO-8-OXO-N-PHENYLNONANAMIDE \| 9,9,9-T...) Show SMILES FC(F)(F)C(=O)CCCCCCC(=O)Nc1ccccc1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents	Article PubMed	n/a	n/a	1.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Drexel University Curated by ChEMBL					Assay Description Inhibition of HDAC8 assessed as substrate deacetylation using N-acetyl-L-Arg-LHis-L-Lys(epsilon-acetyl)-L-Lys(epsilon-acetyl)-coumarin as substrate p...				Bioorg Med Chem Lett 21: 5854-8 (2011) Article DOI: 10.1016/j.bmcl.2011.07.100 BindingDB Entry DOI: 10.7270/Q2KS6RZR
Drexel University Curated by ChEMBL					More data for this Ligand-Target Pair
Acetylpolyamine amidohydrolase (Mycoplana ramosa (Gram-negative bacterium))	BDBM50121062 (9,9,9-TRIFLUORO-8-OXO-N-PHENYLNONANAMIDE \| 9,9,9-T...) Show SMILES FC(F)(F)C(=O)CCCCCCC(=O)Nc1ccccc1 Show InChI	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents	Article PubMed	n/a	n/a	1.10E+5	n/a	n/a	n/a	n/a	n/a	n/a
Drexel University Curated by ChEMBL					Assay Description Inhibition of Mycoplana ramosa acetylpolyamine amidohydrolase assessed as substrate deacetylation using L-Lys(epsilon-acetyl)-coumarin as substrate p...				Bioorg Med Chem Lett 21: 5854-8 (2011) Article DOI: 10.1016/j.bmcl.2011.07.100 BindingDB Entry DOI: 10.7270/Q2KS6RZR
Drexel University Curated by ChEMBL					More data for this Ligand-Target Pair
Arginase-1 (Homo sapiens (Human))	BDBM50354832 (CHEMBL1834160) Show SMILES N[C@@H](CCCCC=O)C(O)=O \|r\| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	6.00E+4	n/a	n/a	n/a	n/a	n/a
Drexel University Curated by ChEMBL					Assay Description Displacement of [14C-guanidino]-L-arginine from human recombinant full length arginase 1 expressed in Escherichia coli BL21(DE3) by fixed point assay				Bioorg Med Chem Lett 21: 5854-8 (2011) Article DOI: 10.1016/j.bmcl.2011.07.100 BindingDB Entry DOI: 10.7270/Q2KS6RZR
Drexel University Curated by ChEMBL					More data for this Ligand-Target Pair