Compile Data Set for Download or QSAR

Found 132 hits Enz. Inhib. hit(s) with all data for entry = 50034482   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cyclin-A2/Cyclin-dependent kinase 2 (Homo sapiens (Human))	BDBM50363198 (CHEMBL1946006) Show SMILES CN1C\C=C\CCOc2cccc(c2)-c2ccnc(Nc3cc(N)cc(C1)c3)n2 |t:3| Show InChI InChI=1S/C23H25N5O/c1-28-10-3-2-4-11-29-21-7-5-6-18(14-21)22-8-9-25-23(27-22)26-20-13-17(16-28)12-19(24)15-20/h2-3,5-9,12-15H,4,10-11,16,24H2,1H3,(H,25,26,27)/b3-2+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	n/a
S BIO Pte. Ltd. Curated by ChEMBL					Assay Description Inhibition of recombinant Cdk2/cyclin A using RbING as substrate after 2 hrs by luminescence assay				J Med Chem 55: 169-96 (2012) Checked by Author Article DOI: 10.1021/jm201112g BindingDB Entry DOI: 10.7270/Q2M61KPN
					More data for this Ligand-Target Pair
Cyclin-A2/Cyclin-dependent kinase 2 (Homo sapiens (Human))	BDBM50363199 (CHEMBL1946150) Show SMILES CCS(=O)(=O)CNc1cc2CN(C)C\C=C\CCOc3cccc(c3)-c3ccnc(Nc(c2)c1)n3 |t:14| Show InChI InChI=1S/C26H31N5O3S/c1-3-35(32,33)19-28-22-14-20-15-23(17-22)29-26-27-11-10-25(30-26)21-8-7-9-24(16-21)34-13-6-4-5-12-31(2)18-20/h4-5,7-11,14-17,28H,3,6,12-13,18-19H2,1-2H3,(H,27,29,30)/b5-4+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	8	n/a	n/a	n/a	n/a	n/a	n/a
S BIO Pte. Ltd. Curated by ChEMBL					Assay Description Inhibition of recombinant Cdk2/cyclin A using RbING as substrate after 2 hrs by luminescence assay				J Med Chem 55: 169-96 (2012) Checked by Author Article DOI: 10.1021/jm201112g BindingDB Entry DOI: 10.7270/Q2M61KPN
					More data for this Ligand-Target Pair
Cyclin-A2/Cyclin-dependent kinase 2 (Homo sapiens (Human))	BDBM50363197 (CHEMBL1946005) Show SMILES CN1C\C=C\CCOc2cccc(c2)-c2ccnc(Nc3cc(C1)cc(NC(=O)C(F)(F)F)c3)n2 |t:3| Show InChI InChI=1S/C25H24F3N5O2/c1-33-10-3-2-4-11-35-21-7-5-6-18(14-21)22-8-9-29-24(32-22)31-20-13-17(16-33)12-19(15-20)30-23(34)25(26,27)28/h2-3,5-9,12-15H,4,10-11,16H2,1H3,(H,30,34)(H,29,31,32)/b3-2+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	8	n/a	n/a	n/a	n/a	n/a	n/a
S BIO Pte. Ltd. Curated by ChEMBL					Assay Description Inhibition of recombinant Cdk2/cyclin A using RbING as substrate after 2 hrs by luminescence assay				J Med Chem 55: 169-96 (2012) Checked by Author Article DOI: 10.1021/jm201112g BindingDB Entry DOI: 10.7270/Q2M61KPN
					More data for this Ligand-Target Pair
Cyclin-A2/Cyclin-dependent kinase 2 (Homo sapiens (Human))	BDBM50363202 (CHEMBL1946442) Show SMILES CN1C\C=C\CCOc2cc(F)cc(c2)-c2ccnc(Nc3cccc(C1)c3)n2 |t:3| Show InChI InChI=1S/C23H23FN4O/c1-28-10-3-2-4-11-29-21-14-18(13-19(24)15-21)22-8-9-25-23(27-22)26-20-7-5-6-17(12-20)16-28/h2-3,5-9,12-15H,4,10-11,16H2,1H3,(H,25,26,27)/b3-2+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	9	n/a	n/a	n/a	n/a	n/a	n/a
S BIO Pte. Ltd. Curated by ChEMBL					Assay Description Inhibition of recombinant Cdk2/cyclin A using RbING as substrate after 2 hrs by luminescence assay				J Med Chem 55: 169-96 (2012) Checked by Author Article DOI: 10.1021/jm201112g BindingDB Entry DOI: 10.7270/Q2M61KPN
					More data for this Ligand-Target Pair
Cyclin-A2/Cyclin-dependent kinase 2 (Homo sapiens (Human))	BDBM50363196 (CHEMBL1944698) Show SMILES CN1C\C=C\CCOc2cccc(c2)-c2ccnc(Nc3cccc(C1)c3)n2 |t:3| Show InChI InChI=1S/C23H24N4O/c1-27-13-3-2-4-14-28-21-10-6-8-19(16-21)22-11-12-24-23(26-22)25-20-9-5-7-18(15-20)17-27/h2-3,5-12,15-16H,4,13-14,17H2,1H3,(H,24,25,26)/b3-2+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
S BIO Pte. Ltd. Curated by ChEMBL					Assay Description Inhibition of recombinant Cdk2/cyclin A using RbING as substrate after 2 hrs by luminescence assay				J Med Chem 55: 169-96 (2012) Checked by Author Article DOI: 10.1021/jm201112g BindingDB Entry DOI: 10.7270/Q2M61KPN
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM50363199 (CHEMBL1946150) Show SMILES CCS(=O)(=O)CNc1cc2CN(C)C\C=C\CCOc3cccc(c3)-c3ccnc(Nc(c2)c1)n3 |t:14| Show InChI InChI=1S/C26H31N5O3S/c1-3-35(32,33)19-28-22-14-20-15-23(17-22)29-26-27-11-10-25(30-26)21-8-7-9-24(16-21)34-13-6-4-5-12-31(2)18-20/h4-5,7-11,14-17,28H,3,6,12-13,18-19H2,1-2H3,(H,27,29,30)/b5-4+	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	18	n/a	n/a	n/a	n/a	n/a	n/a
S BIO Pte. Ltd. Curated by ChEMBL					Assay Description Inhibition of recombinant JAK2 using poly(Glu,Ala,Tyr) as substrate after 2 hrs by luminescence assay				J Med Chem 55: 169-96 (2012) Checked by Author Article DOI: 10.1021/jm201112g BindingDB Entry DOI: 10.7270/Q2M61KPN
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM50363198 (CHEMBL1946006) Show SMILES CN1C\C=C\CCOc2cccc(c2)-c2ccnc(Nc3cc(N)cc(C1)c3)n2 |t:3| Show InChI InChI=1S/C23H25N5O/c1-28-10-3-2-4-11-29-21-7-5-6-18(14-21)22-8-9-25-23(27-22)26-20-13-17(16-28)12-19(24)15-20/h2-3,5-9,12-15H,4,10-11,16,24H2,1H3,(H,25,26,27)/b3-2+	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	19	n/a	n/a	n/a	n/a	n/a	n/a
S BIO Pte. Ltd. Curated by ChEMBL					Assay Description Inhibition of recombinant Flt3 using poly(Glu,Tyr) as substrate after 2 hrs by luminescence assay				J Med Chem 55: 169-96 (2012) Checked by Author Article DOI: 10.1021/jm201112g BindingDB Entry DOI: 10.7270/Q2M61KPN
					More data for this Ligand-Target Pair
Cyclin-A2/Cyclin-dependent kinase 2 (Homo sapiens (Human))	BDBM50363211 (CHEMBL1947162) Show SMILES C1C\C=C\CNCc2cccc(Nc3nccc(n3)-c3cccc(O1)c3)c2 |t:2| Show InChI InChI=1S/C22H22N4O/c1-2-11-23-16-17-6-4-8-19(14-17)25-22-24-12-10-21(26-22)18-7-5-9-20(15-18)27-13-3-1/h1-2,4-10,12,14-15,23H,3,11,13,16H2,(H,24,25,26)/b2-1+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	21	n/a	n/a	n/a	n/a	n/a	n/a
S BIO Pte. Ltd. Curated by ChEMBL					Assay Description Inhibition of recombinant Cdk2/cyclin A using RbING as substrate after 2 hrs by luminescence assay				J Med Chem 55: 169-96 (2012) Checked by Author Article DOI: 10.1021/jm201112g BindingDB Entry DOI: 10.7270/Q2M61KPN
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM50360580 (CHEMBL1933343) Show SMILES CN1C\C=C\CCOc2cccc(c2)-c2nc(Nc3cccc(C1)c3)ncc2C |t:3| Show InChI InChI=1S/C24H26N4O/c1-18-16-25-24-26-21-10-6-8-19(14-21)17-28(2)12-4-3-5-13-29-22-11-7-9-20(15-22)23(18)27-24/h3-4,6-11,14-16H,5,12-13,17H2,1-2H3,(H,25,26,27)/b4-3+	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	22	n/a	n/a	n/a	n/a	n/a	n/a
S BIO Pte. Ltd. Curated by ChEMBL					Assay Description Inhibition of recombinant Flt3 using poly(Glu,Tyr) as substrate after 2 hrs by luminescence assay				J Med Chem 55: 169-96 (2012) Checked by Author Article DOI: 10.1021/jm201112g BindingDB Entry DOI: 10.7270/Q2M61KPN
					More data for this Ligand-Target Pair
Cyclin-A2/Cyclin-dependent kinase 2 (Homo sapiens (Human))	BDBM50363225 (CHEMBL1945566) Show SMILES CCS(=O)(=O)c1ccc2Nc3nccc(n3)-c3cccc(OCC\C=C\CN(C)Cc1c2)c3 |t:25| Show InChI InChI=1S/C25H28N4O3S/c1-3-33(30,31)24-11-10-21-16-20(24)18-29(2)14-5-4-6-15-32-22-9-7-8-19(17-22)23-12-13-26-25(27-21)28-23/h4-5,7-13,16-17H,3,6,14-15,18H2,1-2H3,(H,26,27,28)/b5-4+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	22	n/a	n/a	n/a	n/a	n/a	n/a
S BIO Pte. Ltd. Curated by ChEMBL					Assay Description Inhibition of recombinant Cdk2/cyclin A using RbING as substrate after 2 hrs by luminescence assay				J Med Chem 55: 169-96 (2012) Checked by Author Article DOI: 10.1021/jm201112g BindingDB Entry DOI: 10.7270/Q2M61KPN
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM50363197 (CHEMBL1946005) Show SMILES CN1C\C=C\CCOc2cccc(c2)-c2ccnc(Nc3cc(C1)cc(NC(=O)C(F)(F)F)c3)n2 |t:3| Show InChI InChI=1S/C25H24F3N5O2/c1-33-10-3-2-4-11-35-21-7-5-6-18(14-21)22-8-9-29-24(32-22)31-20-13-17(16-33)12-19(15-20)30-23(34)25(26,27)28/h2-3,5-9,12-15H,4,10-11,16H2,1H3,(H,30,34)(H,29,31,32)/b3-2+	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	23	n/a	n/a	n/a	n/a	n/a	n/a
S BIO Pte. Ltd. Curated by ChEMBL					Assay Description Inhibition of recombinant Flt3 using poly(Glu,Tyr) as substrate after 2 hrs by luminescence assay				J Med Chem 55: 169-96 (2012) Checked by Author Article DOI: 10.1021/jm201112g BindingDB Entry DOI: 10.7270/Q2M61KPN
					More data for this Ligand-Target Pair
Cyclin-A2/Cyclin-dependent kinase 2 (Homo sapiens (Human))	BDBM50363222 (CHEMBL1945051) Show SMILES CN1C\C=C\CCOc2cccc(c2)-c2ccnc(Nc3ccc(Cl)c(C1)c3)n2 |t:3| Show InChI InChI=1S/C23H23ClN4O/c1-28-12-3-2-4-13-29-20-7-5-6-17(15-20)22-10-11-25-23(27-22)26-19-8-9-21(24)18(14-19)16-28/h2-3,5-11,14-15H,4,12-13,16H2,1H3,(H,25,26,27)/b3-2+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	24	n/a	n/a	n/a	n/a	n/a	n/a
S BIO Pte. Ltd. Curated by ChEMBL					Assay Description Inhibition of recombinant Cdk2/cyclin A using RbING as substrate after 2 hrs by luminescence assay				J Med Chem 55: 169-96 (2012) Checked by Author Article DOI: 10.1021/jm201112g BindingDB Entry DOI: 10.7270/Q2M61KPN
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM50363224 (CHEMBL1945565) Show SMILES COCCOc1ccc2Nc3nccc(n3)-c3cccc(OCC\C=C\CN(C)Cc1c2)c3 |t:25| Show InChI InChI=1S/C26H30N4O3/c1-30-13-4-3-5-14-32-23-8-6-7-20(18-23)24-11-12-27-26(29-24)28-22-9-10-25(21(17-22)19-30)33-16-15-31-2/h3-4,6-12,17-18H,5,13-16,19H2,1-2H3,(H,27,28,29)/b4-3+	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	25	n/a	n/a	n/a	n/a	n/a	n/a
S BIO Pte. Ltd. Curated by ChEMBL					Assay Description Inhibition of recombinant Flt3 using poly(Glu,Tyr) as substrate after 2 hrs by luminescence assay				J Med Chem 55: 169-96 (2012) Checked by Author Article DOI: 10.1021/jm201112g BindingDB Entry DOI: 10.7270/Q2M61KPN
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM50363235 (CHEMBL1945823) Show SMILES N#CCN1C\C=C\CCOc2cccc(c2)-c2ccnc(Nc3ccc(OCCN4CCCC4)c(C1)c3)n2 |t:5| Show InChI InChI=1S/C30H34N6O2/c31-12-17-36-16-2-1-5-19-37-27-8-6-7-24(22-27)28-11-13-32-30(34-28)33-26-9-10-29(25(21-26)23-36)38-20-18-35-14-3-4-15-35/h1-2,6-11,13,21-22H,3-5,14-20,23H2,(H,32,33,34)/b2-1+	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	29	n/a	n/a	n/a	n/a	n/a	n/a
S BIO Pte. Ltd. Curated by ChEMBL					Assay Description Inhibition of recombinant Flt3 using poly(Glu,Tyr) as substrate after 2 hrs by luminescence assay				J Med Chem 55: 169-96 (2012) Checked by Author Article DOI: 10.1021/jm201112g BindingDB Entry DOI: 10.7270/Q2M61KPN
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM50363229 (CHEMBL1945703) Show SMILES CCN(CC)CCOc1ccc2Nc3nccc(n3)-c3cccc(OCC\C=C\CN(C)Cc1c2)c3 |t:28| Show InChI InChI=1S/C29H37N5O2/c1-4-34(5-2)17-19-36-28-13-12-25-20-24(28)22-33(3)16-7-6-8-18-35-26-11-9-10-23(21-26)27-14-15-30-29(31-25)32-27/h6-7,9-15,20-21H,4-5,8,16-19,22H2,1-3H3,(H,30,31,32)/b7-6+	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	30	n/a	n/a	n/a	n/a	n/a	n/a
S BIO Pte. Ltd. Curated by ChEMBL					Assay Description Inhibition of recombinant Flt3 using poly(Glu,Tyr) as substrate after 2 hrs by luminescence assay				J Med Chem 55: 169-96 (2012) Checked by Author Article DOI: 10.1021/jm201112g BindingDB Entry DOI: 10.7270/Q2M61KPN
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM50363202 (CHEMBL1946442) Show SMILES CN1C\C=C\CCOc2cc(F)cc(c2)-c2ccnc(Nc3cccc(C1)c3)n2 |t:3| Show InChI InChI=1S/C23H23FN4O/c1-28-10-3-2-4-11-29-21-14-18(13-19(24)15-21)22-8-9-25-23(27-22)26-20-7-5-6-17(12-20)16-28/h2-3,5-9,12-15H,4,10-11,16H2,1H3,(H,25,26,27)/b3-2+	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	30	n/a	n/a	n/a	n/a	n/a	n/a
S BIO Pte. Ltd. Curated by ChEMBL					Assay Description Inhibition of recombinant Flt3 using poly(Glu,Tyr) as substrate after 2 hrs by luminescence assay				J Med Chem 55: 169-96 (2012) Checked by Author Article DOI: 10.1021/jm201112g BindingDB Entry DOI: 10.7270/Q2M61KPN
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM50363230 (CHEMBL1945704) Show SMILES CN1C\C=C\CCOc2cccc(c2)-c2ccnc(Nc3ccc(OCCN4CCCC4)c(C1)c3)n2 |t:3| Show InChI InChI=1S/C29H35N5O2/c1-33-14-3-2-6-18-35-26-9-7-8-23(21-26)27-12-13-30-29(32-27)31-25-10-11-28(24(20-25)22-33)36-19-17-34-15-4-5-16-34/h2-3,7-13,20-21H,4-6,14-19,22H2,1H3,(H,30,31,32)/b3-2+	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	35	n/a	n/a	n/a	n/a	n/a	n/a
S BIO Pte. Ltd. Curated by ChEMBL					Assay Description Inhibition of recombinant Flt3 using poly(Glu,Tyr) as substrate after 2 hrs by luminescence assay				J Med Chem 55: 169-96 (2012) Checked by Author Article DOI: 10.1021/jm201112g BindingDB Entry DOI: 10.7270/Q2M61KPN
					More data for this Ligand-Target Pair
Cyclin-A2/Cyclin-dependent kinase 2 (Homo sapiens (Human))	BDBM50363214 (CHEMBL1944701) Show SMILES C1CC1N1C\C=C\CCOc2cccc(c2)-c2ccnc(Nc3cccc(C1)c3)n2 |t:6| Show InChI InChI=1S/C25H26N4O/c1-2-14-29(22-10-11-22)18-19-6-4-8-21(16-19)27-25-26-13-12-24(28-25)20-7-5-9-23(17-20)30-15-3-1/h1-2,4-9,12-13,16-17,22H,3,10-11,14-15,18H2,(H,26,27,28)/b2-1+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	36	n/a	n/a	n/a	n/a	n/a	n/a
S BIO Pte. Ltd. Curated by ChEMBL					Assay Description Inhibition of recombinant Cdk2/cyclin A using RbING as substrate after 2 hrs by luminescence assay				J Med Chem 55: 169-96 (2012) Checked by Author Article DOI: 10.1021/jm201112g BindingDB Entry DOI: 10.7270/Q2M61KPN
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM50363200 (CHEMBL1946151) Show SMILES CN1C\C=C\CCOc2cccc(c2)-c2ccnc(Nc3cc(C1)cc(NC(=O)N1CCOCC1)c3)n2 |t:3| Show InChI InChI=1S/C28H32N6O3/c1-33-10-3-2-4-13-37-25-7-5-6-22(18-25)26-8-9-29-27(32-26)30-23-16-21(20-33)17-24(19-23)31-28(35)34-11-14-36-15-12-34/h2-3,5-9,16-19H,4,10-15,20H2,1H3,(H,31,35)(H,29,30,32)/b3-2+	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	37	n/a	n/a	n/a	n/a	n/a	n/a
S BIO Pte. Ltd. Curated by ChEMBL					Assay Description Inhibition of recombinant Flt3 using poly(Glu,Tyr) as substrate after 2 hrs by luminescence assay				J Med Chem 55: 169-96 (2012) Checked by Author Article DOI: 10.1021/jm201112g BindingDB Entry DOI: 10.7270/Q2M61KPN
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM50363231 (CHEMBL1945705) Show SMILES CN1C\C=C\CCOc2cccc(c2)-c2ccnc(Nc3ccc(OCCN4CCOCC4)c(C1)c3)n2 |t:3| Show InChI InChI=1S/C29H35N5O3/c1-33-12-3-2-4-16-36-26-7-5-6-23(21-26)27-10-11-30-29(32-27)31-25-8-9-28(24(20-25)22-33)37-19-15-34-13-17-35-18-14-34/h2-3,5-11,20-21H,4,12-19,22H2,1H3,(H,30,31,32)/b3-2+	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	40	n/a	n/a	n/a	n/a	n/a	n/a
S BIO Pte. Ltd. Curated by ChEMBL					Assay Description Inhibition of recombinant Flt3 using poly(Glu,Tyr) as substrate after 2 hrs by luminescence assay				J Med Chem 55: 169-96 (2012) Checked by Author Article DOI: 10.1021/jm201112g BindingDB Entry DOI: 10.7270/Q2M61KPN
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM50363214 (CHEMBL1944701) Show SMILES C1CC1N1C\C=C\CCOc2cccc(c2)-c2ccnc(Nc3cccc(C1)c3)n2 |t:6| Show InChI InChI=1S/C25H26N4O/c1-2-14-29(22-10-11-22)18-19-6-4-8-21(16-19)27-25-26-13-12-24(28-25)20-7-5-9-23(17-20)30-15-3-1/h1-2,4-9,12-13,16-17,22H,3,10-11,14-15,18H2,(H,26,27,28)/b2-1+	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	42	n/a	n/a	n/a	n/a	n/a	n/a
S BIO Pte. Ltd. Curated by ChEMBL					Assay Description Inhibition of recombinant Flt3 using poly(Glu,Tyr) as substrate after 2 hrs by luminescence assay				J Med Chem 55: 169-96 (2012) Checked by Author Article DOI: 10.1021/jm201112g BindingDB Entry DOI: 10.7270/Q2M61KPN
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM50363200 (CHEMBL1946151) Show SMILES CN1C\C=C\CCOc2cccc(c2)-c2ccnc(Nc3cc(C1)cc(NC(=O)N1CCOCC1)c3)n2 |t:3| Show InChI InChI=1S/C28H32N6O3/c1-33-10-3-2-4-13-37-25-7-5-6-22(18-25)26-8-9-29-27(32-26)30-23-16-21(20-33)17-24(19-23)31-28(35)34-11-14-36-15-12-34/h2-3,5-9,16-19H,4,10-15,20H2,1H3,(H,31,35)(H,29,30,32)/b3-2+	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	44	n/a	n/a	n/a	n/a	n/a	n/a
S BIO Pte. Ltd. Curated by ChEMBL					Assay Description Inhibition of recombinant JAK2 using poly(Glu,Ala,Tyr) as substrate after 2 hrs by luminescence assay				J Med Chem 55: 169-96 (2012) Checked by Author Article DOI: 10.1021/jm201112g BindingDB Entry DOI: 10.7270/Q2M61KPN
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM50363233 (CHEMBL1945707) Show SMILES CN1C\C=C\CCOc2cccc(c2)-c2ccnc(Nc3ccc(OCCN4CCCCC4)c(C1)c3)n2 |t:3| Show InChI InChI=1S/C30H37N5O2/c1-34-15-4-3-7-19-36-27-10-8-9-24(22-27)28-13-14-31-30(33-28)32-26-11-12-29(25(21-26)23-34)37-20-18-35-16-5-2-6-17-35/h3-4,8-14,21-22H,2,5-7,15-20,23H2,1H3,(H,31,32,33)/b4-3+	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	45	n/a	n/a	n/a	n/a	n/a	n/a
S BIO Pte. Ltd. Curated by ChEMBL					Assay Description Inhibition of recombinant Flt3 using poly(Glu,Tyr) as substrate after 2 hrs by luminescence assay				J Med Chem 55: 169-96 (2012) Checked by Author Article DOI: 10.1021/jm201112g BindingDB Entry DOI: 10.7270/Q2M61KPN
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM50363229 (CHEMBL1945703) Show SMILES CCN(CC)CCOc1ccc2Nc3nccc(n3)-c3cccc(OCC\C=C\CN(C)Cc1c2)c3 |t:28| Show InChI InChI=1S/C29H37N5O2/c1-4-34(5-2)17-19-36-28-13-12-25-20-24(28)22-33(3)16-7-6-8-18-35-26-11-9-10-23(21-26)27-14-15-30-29(31-25)32-27/h6-7,9-15,20-21H,4-5,8,16-19,22H2,1-3H3,(H,30,31,32)/b7-6+	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	48	n/a	n/a	n/a	n/a	n/a	n/a
S BIO Pte. Ltd. Curated by ChEMBL					Assay Description Inhibition of recombinant JAK2 using poly(Glu,Ala,Tyr) as substrate after 2 hrs by luminescence assay				J Med Chem 55: 169-96 (2012) Checked by Author Article DOI: 10.1021/jm201112g BindingDB Entry DOI: 10.7270/Q2M61KPN
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM50363228 (CHEMBL1945569) Show SMILES CN1C\C=C\CCOc2cccc(c2)-c2ccnc(Nc3ccc(N4CCOCC4)c(C1)c3)n2 |t:3| Show InChI InChI=1S/C27H31N5O2/c1-31-12-3-2-4-15-34-24-7-5-6-21(19-24)25-10-11-28-27(30-25)29-23-8-9-26(22(18-23)20-31)32-13-16-33-17-14-32/h2-3,5-11,18-19H,4,12-17,20H2,1H3,(H,28,29,30)/b3-2+	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	49	n/a	n/a	n/a	n/a	n/a	n/a
S BIO Pte. Ltd. Curated by ChEMBL					Assay Description Inhibition of recombinant JAK2 using poly(Glu,Ala,Tyr) as substrate after 2 hrs by luminescence assay				J Med Chem 55: 169-96 (2012) Checked by Author Article DOI: 10.1021/jm201112g BindingDB Entry DOI: 10.7270/Q2M61KPN
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM50363197 (CHEMBL1946005) Show SMILES CN1C\C=C\CCOc2cccc(c2)-c2ccnc(Nc3cc(C1)cc(NC(=O)C(F)(F)F)c3)n2 |t:3| Show InChI InChI=1S/C25H24F3N5O2/c1-33-10-3-2-4-11-35-21-7-5-6-18(14-21)22-8-9-29-24(32-22)31-20-13-17(16-33)12-19(15-20)30-23(34)25(26,27)28/h2-3,5-9,12-15H,4,10-11,16H2,1H3,(H,30,34)(H,29,31,32)/b3-2+	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	50	n/a	n/a	n/a	n/a	n/a	n/a
S BIO Pte. Ltd. Curated by ChEMBL					Assay Description Inhibition of recombinant JAK2 using poly(Glu,Ala,Tyr) as substrate after 2 hrs by luminescence assay				J Med Chem 55: 169-96 (2012) Checked by Author Article DOI: 10.1021/jm201112g BindingDB Entry DOI: 10.7270/Q2M61KPN
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM50363198 (CHEMBL1946006) Show SMILES CN1C\C=C\CCOc2cccc(c2)-c2ccnc(Nc3cc(N)cc(C1)c3)n2 |t:3| Show InChI InChI=1S/C23H25N5O/c1-28-10-3-2-4-11-29-21-7-5-6-18(14-21)22-8-9-25-23(27-22)26-20-13-17(16-28)12-19(24)15-20/h2-3,5-9,12-15H,4,10-11,16,24H2,1H3,(H,25,26,27)/b3-2+	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	50	n/a	n/a	n/a	n/a	n/a	n/a
S BIO Pte. Ltd. Curated by ChEMBL					Assay Description Inhibition of recombinant JAK2 using poly(Glu,Ala,Tyr) as substrate after 2 hrs by luminescence assay				J Med Chem 55: 169-96 (2012) Checked by Author Article DOI: 10.1021/jm201112g BindingDB Entry DOI: 10.7270/Q2M61KPN
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM50363230 (CHEMBL1945704) Show SMILES CN1C\C=C\CCOc2cccc(c2)-c2ccnc(Nc3ccc(OCCN4CCCC4)c(C1)c3)n2 |t:3| Show InChI InChI=1S/C29H35N5O2/c1-33-14-3-2-6-18-35-26-9-7-8-23(21-26)27-12-13-30-29(32-27)31-25-10-11-28(24(20-25)22-33)36-19-17-34-15-4-5-16-34/h2-3,7-13,20-21H,4-6,14-19,22H2,1H3,(H,30,31,32)/b3-2+	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	56	n/a	n/a	n/a	n/a	n/a	n/a
S BIO Pte. Ltd. Curated by ChEMBL					Assay Description Inhibition of recombinant JAK2 using poly(Glu,Ala,Tyr) as substrate after 2 hrs by luminescence assay				J Med Chem 55: 169-96 (2012) Checked by Author Article DOI: 10.1021/jm201112g BindingDB Entry DOI: 10.7270/Q2M61KPN
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM50363196 (CHEMBL1944698) Show SMILES CN1C\C=C\CCOc2cccc(c2)-c2ccnc(Nc3cccc(C1)c3)n2 |t:3| Show InChI InChI=1S/C23H24N4O/c1-27-13-3-2-4-14-28-21-10-6-8-19(16-21)22-11-12-24-23(26-22)25-20-9-5-7-18(15-20)17-27/h2-3,5-12,15-16H,4,13-14,17H2,1H3,(H,24,25,26)/b3-2+	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	56	n/a	n/a	n/a	n/a	n/a	n/a
S BIO Pte. Ltd. Curated by ChEMBL					Assay Description Inhibition of recombinant Flt3 using poly(Glu,Tyr) as substrate after 2 hrs by luminescence assay				J Med Chem 55: 169-96 (2012) Checked by Author Article DOI: 10.1021/jm201112g BindingDB Entry DOI: 10.7270/Q2M61KPN
					More data for this Ligand-Target Pair
Cyclin-A2/Cyclin-dependent kinase 2 (Homo sapiens (Human))	BDBM50363223 (CHEMBL1945052) Show SMILES CN1C\C=C\CCOc2cccc(c2)-c2ccnc(Nc3ccc(OC(F)(F)F)c(C1)c3)n2 |t:3| Show InChI InChI=1S/C24H23F3N4O2/c1-31-12-3-2-4-13-32-20-7-5-6-17(15-20)21-10-11-28-23(30-21)29-19-8-9-22(18(14-19)16-31)33-24(25,26)27/h2-3,5-11,14-15H,4,12-13,16H2,1H3,(H,28,29,30)/b3-2+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	57	n/a	n/a	n/a	n/a	n/a	n/a
S BIO Pte. Ltd. Curated by ChEMBL					Assay Description Inhibition of recombinant Cdk2/cyclin A using RbING as substrate after 2 hrs by luminescence assay				J Med Chem 55: 169-96 (2012) Checked by Author Article DOI: 10.1021/jm201112g BindingDB Entry DOI: 10.7270/Q2M61KPN
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM50363233 (CHEMBL1945707) Show SMILES CN1C\C=C\CCOc2cccc(c2)-c2ccnc(Nc3ccc(OCCN4CCCCC4)c(C1)c3)n2 |t:3| Show InChI InChI=1S/C30H37N5O2/c1-34-15-4-3-7-19-36-27-10-8-9-24(22-27)28-13-14-31-30(33-28)32-26-11-12-29(25(21-26)23-34)37-20-18-35-16-5-2-6-17-35/h3-4,8-14,21-22H,2,5-7,15-20,23H2,1H3,(H,31,32,33)/b4-3+	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	62	n/a	n/a	n/a	n/a	n/a	n/a
S BIO Pte. Ltd. Curated by ChEMBL					Assay Description Inhibition of recombinant JAK2 using poly(Glu,Ala,Tyr) as substrate after 2 hrs by luminescence assay				J Med Chem 55: 169-96 (2012) Checked by Author Article DOI: 10.1021/jm201112g BindingDB Entry DOI: 10.7270/Q2M61KPN
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM50363224 (CHEMBL1945565) Show SMILES COCCOc1ccc2Nc3nccc(n3)-c3cccc(OCC\C=C\CN(C)Cc1c2)c3 |t:25| Show InChI InChI=1S/C26H30N4O3/c1-30-13-4-3-5-14-32-23-8-6-7-20(18-23)24-11-12-27-26(29-24)28-22-9-10-25(21(17-22)19-30)33-16-15-31-2/h3-4,6-12,17-18H,5,13-16,19H2,1-2H3,(H,27,28,29)/b4-3+	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	62	n/a	n/a	n/a	n/a	n/a	n/a
S BIO Pte. Ltd. Curated by ChEMBL					Assay Description Inhibition of recombinant JAK2 using poly(Glu,Ala,Tyr) as substrate after 2 hrs by luminescence assay				J Med Chem 55: 169-96 (2012) Checked by Author Article DOI: 10.1021/jm201112g BindingDB Entry DOI: 10.7270/Q2M61KPN
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM50363221 (CHEMBL1945050) Show SMILES COc1ccc2Nc3nccc(n3)-c3cccc(OCC\C=C\CN(C)Cc1c2)c3 |t:22| Show InChI InChI=1S/C24H26N4O2/c1-28-13-4-3-5-14-30-21-8-6-7-18(16-21)22-11-12-25-24(27-22)26-20-9-10-23(29-2)19(15-20)17-28/h3-4,6-12,15-16H,5,13-14,17H2,1-2H3,(H,25,26,27)/b4-3+	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	66	n/a	n/a	n/a	n/a	n/a	n/a
S BIO Pte. Ltd. Curated by ChEMBL					Assay Description Inhibition of recombinant Flt3 using poly(Glu,Tyr) as substrate after 2 hrs by luminescence assay				J Med Chem 55: 169-96 (2012) Checked by Author Article DOI: 10.1021/jm201112g BindingDB Entry DOI: 10.7270/Q2M61KPN
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM50363228 (CHEMBL1945569) Show SMILES CN1C\C=C\CCOc2cccc(c2)-c2ccnc(Nc3ccc(N4CCOCC4)c(C1)c3)n2 |t:3| Show InChI InChI=1S/C27H31N5O2/c1-31-12-3-2-4-15-34-24-7-5-6-21(19-24)25-10-11-28-27(30-25)29-23-8-9-26(22(18-23)20-31)32-13-16-33-17-14-32/h2-3,5-11,18-19H,4,12-17,20H2,1H3,(H,28,29,30)/b3-2+	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	71	n/a	n/a	n/a	n/a	n/a	n/a
S BIO Pte. Ltd. Curated by ChEMBL					Assay Description Inhibition of recombinant Flt3 using poly(Glu,Tyr) as substrate after 2 hrs by luminescence assay				J Med Chem 55: 169-96 (2012) Checked by Author Article DOI: 10.1021/jm201112g BindingDB Entry DOI: 10.7270/Q2M61KPN
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM50363196 (CHEMBL1944698) Show SMILES CN1C\C=C\CCOc2cccc(c2)-c2ccnc(Nc3cccc(C1)c3)n2 |t:3| Show InChI InChI=1S/C23H24N4O/c1-27-13-3-2-4-14-28-21-10-6-8-19(16-21)22-11-12-24-23(26-22)25-20-9-5-7-18(15-20)17-27/h2-3,5-12,15-16H,4,13-14,17H2,1H3,(H,24,25,26)/b3-2+	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	73	n/a	n/a	n/a	n/a	n/a	n/a
S BIO Pte. Ltd. Curated by ChEMBL					Assay Description Inhibition of recombinant JAK2 using poly(Glu,Ala,Tyr) as substrate after 2 hrs by luminescence assay				J Med Chem 55: 169-96 (2012) Checked by Author Article DOI: 10.1021/jm201112g BindingDB Entry DOI: 10.7270/Q2M61KPN
					More data for this Ligand-Target Pair
Cyclin-A2/Cyclin-dependent kinase 2 (Homo sapiens (Human))	BDBM50363228 (CHEMBL1945569) Show SMILES CN1C\C=C\CCOc2cccc(c2)-c2ccnc(Nc3ccc(N4CCOCC4)c(C1)c3)n2 |t:3| Show InChI InChI=1S/C27H31N5O2/c1-31-12-3-2-4-15-34-24-7-5-6-21(19-24)25-10-11-28-27(30-25)29-23-8-9-26(22(18-23)20-31)32-13-16-33-17-14-32/h2-3,5-11,18-19H,4,12-17,20H2,1H3,(H,28,29,30)/b3-2+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	74	n/a	n/a	n/a	n/a	n/a	n/a
S BIO Pte. Ltd. Curated by ChEMBL					Assay Description Inhibition of recombinant Cdk2/cyclin A using RbING as substrate after 2 hrs by luminescence assay				J Med Chem 55: 169-96 (2012) Checked by Author Article DOI: 10.1021/jm201112g BindingDB Entry DOI: 10.7270/Q2M61KPN
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM50363222 (CHEMBL1945051) Show SMILES CN1C\C=C\CCOc2cccc(c2)-c2ccnc(Nc3ccc(Cl)c(C1)c3)n2 |t:3| Show InChI InChI=1S/C23H23ClN4O/c1-28-12-3-2-4-13-29-20-7-5-6-17(15-20)22-10-11-25-23(27-22)26-19-8-9-21(24)18(14-19)16-28/h2-3,5-11,14-15H,4,12-13,16H2,1H3,(H,25,26,27)/b3-2+	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	77	n/a	n/a	n/a	n/a	n/a	n/a
S BIO Pte. Ltd. Curated by ChEMBL					Assay Description Inhibition of recombinant Flt3 using poly(Glu,Tyr) as substrate after 2 hrs by luminescence assay				J Med Chem 55: 169-96 (2012) Checked by Author Article DOI: 10.1021/jm201112g BindingDB Entry DOI: 10.7270/Q2M61KPN
					More data for this Ligand-Target Pair
Cyclin-A2/Cyclin-dependent kinase 2 (Homo sapiens (Human))	BDBM50363221 (CHEMBL1945050) Show SMILES COc1ccc2Nc3nccc(n3)-c3cccc(OCC\C=C\CN(C)Cc1c2)c3 |t:22| Show InChI InChI=1S/C24H26N4O2/c1-28-13-4-3-5-14-30-21-8-6-7-18(16-21)22-11-12-25-24(27-22)26-20-9-10-23(29-2)19(15-20)17-28/h3-4,6-12,15-16H,5,13-14,17H2,1-2H3,(H,25,26,27)/b4-3+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	77	n/a	n/a	n/a	n/a	n/a	n/a
S BIO Pte. Ltd. Curated by ChEMBL					Assay Description Inhibition of recombinant Cdk2/cyclin A using RbING as substrate after 2 hrs by luminescence assay				J Med Chem 55: 169-96 (2012) Checked by Author Article DOI: 10.1021/jm201112g BindingDB Entry DOI: 10.7270/Q2M61KPN
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM50363222 (CHEMBL1945051) Show SMILES CN1C\C=C\CCOc2cccc(c2)-c2ccnc(Nc3ccc(Cl)c(C1)c3)n2 |t:3| Show InChI InChI=1S/C23H23ClN4O/c1-28-12-3-2-4-13-29-20-7-5-6-17(15-20)22-10-11-25-23(27-22)26-19-8-9-21(24)18(14-19)16-28/h2-3,5-11,14-15H,4,12-13,16H2,1H3,(H,25,26,27)/b3-2+	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	82	n/a	n/a	n/a	n/a	n/a	n/a
S BIO Pte. Ltd. Curated by ChEMBL					Assay Description Inhibition of recombinant JAK2 using poly(Glu,Ala,Tyr) as substrate after 2 hrs by luminescence assay				J Med Chem 55: 169-96 (2012) Checked by Author Article DOI: 10.1021/jm201112g BindingDB Entry DOI: 10.7270/Q2M61KPN
					More data for this Ligand-Target Pair
Cyclin-A2/Cyclin-dependent kinase 2 (Homo sapiens (Human))	BDBM50363200 (CHEMBL1946151) Show SMILES CN1C\C=C\CCOc2cccc(c2)-c2ccnc(Nc3cc(C1)cc(NC(=O)N1CCOCC1)c3)n2 |t:3| Show InChI InChI=1S/C28H32N6O3/c1-33-10-3-2-4-13-37-25-7-5-6-22(18-25)26-8-9-29-27(32-26)30-23-16-21(20-33)17-24(19-23)31-28(35)34-11-14-36-15-12-34/h2-3,5-9,16-19H,4,10-15,20H2,1H3,(H,31,35)(H,29,30,32)/b3-2+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	87	n/a	n/a	n/a	n/a	n/a	n/a
S BIO Pte. Ltd. Curated by ChEMBL					Assay Description Inhibition of recombinant Cdk2/cyclin A using RbING as substrate after 2 hrs by luminescence assay				J Med Chem 55: 169-96 (2012) Checked by Author Article DOI: 10.1021/jm201112g BindingDB Entry DOI: 10.7270/Q2M61KPN
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM50363214 (CHEMBL1944701) Show SMILES C1CC1N1C\C=C\CCOc2cccc(c2)-c2ccnc(Nc3cccc(C1)c3)n2 |t:6| Show InChI InChI=1S/C25H26N4O/c1-2-14-29(22-10-11-22)18-19-6-4-8-21(16-19)27-25-26-13-12-24(28-25)20-7-5-9-23(17-20)30-15-3-1/h1-2,4-9,12-13,16-17,22H,3,10-11,14-15,18H2,(H,26,27,28)/b2-1+	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	90	n/a	n/a	n/a	n/a	n/a	n/a
S BIO Pte. Ltd. Curated by ChEMBL					Assay Description Inhibition of recombinant JAK2 using poly(Glu,Ala,Tyr) as substrate after 2 hrs by luminescence assay				J Med Chem 55: 169-96 (2012) Checked by Author Article DOI: 10.1021/jm201112g BindingDB Entry DOI: 10.7270/Q2M61KPN
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM50363226 (CHEMBL1945567) Show SMILES CCS(=O)(=O)CCOc1ccc2Nc3nccc(n3)-c3cccc(OCC\C=C\CN(C)Cc1c2)c3 |t:28| Show InChI InChI=1S/C27H32N4O4S/c1-3-36(32,33)17-16-35-26-11-10-23-18-22(26)20-31(2)14-5-4-6-15-34-24-9-7-8-21(19-24)25-12-13-28-27(29-23)30-25/h4-5,7-13,18-19H,3,6,14-17,20H2,1-2H3,(H,28,29,30)/b5-4+	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	93	n/a	n/a	n/a	n/a	n/a	n/a
S BIO Pte. Ltd. Curated by ChEMBL					Assay Description Inhibition of recombinant Flt3 using poly(Glu,Tyr) as substrate after 2 hrs by luminescence assay				J Med Chem 55: 169-96 (2012) Checked by Author Article DOI: 10.1021/jm201112g BindingDB Entry DOI: 10.7270/Q2M61KPN
					More data for this Ligand-Target Pair
Cyclin-A2/Cyclin-dependent kinase 2 (Homo sapiens (Human))	BDBM50363216 (CHEMBL1944871) Show SMILES C(C1CC1)N1C\C=C\CCOc2cccc(c2)-c2ccnc(Nc3cccc(C1)c3)n2 |t:7| Show InChI InChI=1S/C26H28N4O/c1-2-14-30(18-20-10-11-20)19-21-6-4-8-23(16-21)28-26-27-13-12-25(29-26)22-7-5-9-24(17-22)31-15-3-1/h1-2,4-9,12-13,16-17,20H,3,10-11,14-15,18-19H2,(H,27,28,29)/b2-1+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	94	n/a	n/a	n/a	n/a	n/a	n/a
S BIO Pte. Ltd. Curated by ChEMBL					Assay Description Inhibition of recombinant Cdk2/cyclin A using RbING as substrate after 2 hrs by luminescence assay				J Med Chem 55: 169-96 (2012) Checked by Author Article DOI: 10.1021/jm201112g BindingDB Entry DOI: 10.7270/Q2M61KPN
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM50363236 (CHEMBL1946004) Show SMILES COc1cc2Nc3nccc(n3)-c3cccc(OCC\C=C\CN(C)Cc(c2)c1OCCN1CCCC1)c3 |t:21| Show InChI InChI=1S/C30H37N5O3/c1-34-13-4-3-7-17-37-26-10-8-9-23(20-26)27-11-12-31-30(33-27)32-25-19-24(22-34)29(28(21-25)36-2)38-18-16-35-14-5-6-15-35/h3-4,8-12,19-21H,5-7,13-18,22H2,1-2H3,(H,31,32,33)/b4-3+	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	98	n/a	n/a	n/a	n/a	n/a	n/a
S BIO Pte. Ltd. Curated by ChEMBL					Assay Description Inhibition of recombinant Flt3 using poly(Glu,Tyr) as substrate after 2 hrs by luminescence assay				J Med Chem 55: 169-96 (2012) Checked by Author Article DOI: 10.1021/jm201112g BindingDB Entry DOI: 10.7270/Q2M61KPN
					More data for this Ligand-Target Pair
Cyclin-A2/Cyclin-dependent kinase 2 (Homo sapiens (Human))	BDBM50363213 (CHEMBL1944700) Show SMILES CN1C\C=C\COCc2cccc(Nc3nccc(n3)-c3cccc(C1)c3)c2 |t:3| Show InChI InChI=1S/C23H24N4O/c1-27-12-2-3-13-28-17-19-7-5-9-21(15-19)25-23-24-11-10-22(26-23)20-8-4-6-18(14-20)16-27/h2-11,14-15H,12-13,16-17H2,1H3,(H,24,25,26)/b3-2+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	99	n/a	n/a	n/a	n/a	n/a	n/a
S BIO Pte. Ltd. Curated by ChEMBL					Assay Description Inhibition of recombinant Cdk2/cyclin A using RbING as substrate after 2 hrs by luminescence assay				J Med Chem 55: 169-96 (2012) Checked by Author Article DOI: 10.1021/jm201112g BindingDB Entry DOI: 10.7270/Q2M61KPN
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM50363225 (CHEMBL1945566) Show SMILES CCS(=O)(=O)c1ccc2Nc3nccc(n3)-c3cccc(OCC\C=C\CN(C)Cc1c2)c3 |t:25| Show InChI InChI=1S/C25H28N4O3S/c1-3-33(30,31)24-11-10-21-16-20(24)18-29(2)14-5-4-6-15-32-22-9-7-8-19(17-22)23-12-13-26-25(27-21)28-23/h4-5,7-13,16-17H,3,6,14-15,18H2,1-2H3,(H,26,27,28)/b5-4+	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	100	n/a	n/a	n/a	n/a	n/a	n/a
S BIO Pte. Ltd. Curated by ChEMBL					Assay Description Inhibition of recombinant JAK2 using poly(Glu,Ala,Tyr) as substrate after 2 hrs by luminescence assay				J Med Chem 55: 169-96 (2012) Checked by Author Article DOI: 10.1021/jm201112g BindingDB Entry DOI: 10.7270/Q2M61KPN
					More data for this Ligand-Target Pair
Cyclin-A2/Cyclin-dependent kinase 2 (Homo sapiens (Human))	BDBM50363219 (CHEMBL1945047) Show SMILES OCCN1C\C=C\CCOc2cccc(c2)-c2ccnc(Nc3cccc(C1)c3)n2 |t:5| Show InChI InChI=1S/C24H26N4O2/c29-14-13-28-12-2-1-3-15-30-22-9-5-7-20(17-22)23-10-11-25-24(27-23)26-21-8-4-6-19(16-21)18-28/h1-2,4-11,16-17,29H,3,12-15,18H2,(H,25,26,27)/b2-1+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	100	n/a	n/a	n/a	n/a	n/a	n/a
S BIO Pte. Ltd. Curated by ChEMBL					Assay Description Inhibition of recombinant Cdk2/cyclin A using RbING as substrate after 2 hrs by luminescence assay				J Med Chem 55: 169-96 (2012) Checked by Author Article DOI: 10.1021/jm201112g BindingDB Entry DOI: 10.7270/Q2M61KPN
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM50363234 (CHEMBL1945822) Show SMILES FC(F)(F)CN1C\C=C\CCOc2cccc(c2)-c2ccnc(Nc3ccc(OCCN4CCCC4)c(C1)c3)n2 |t:7| Show InChI InChI=1S/C30H34F3N5O2/c31-30(32,33)22-38-15-2-1-5-17-39-26-8-6-7-23(20-26)27-11-12-34-29(36-27)35-25-9-10-28(24(19-25)21-38)40-18-16-37-13-3-4-14-37/h1-2,6-12,19-20H,3-5,13-18,21-22H2,(H,34,35,36)/b2-1+	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	110	n/a	n/a	n/a	n/a	n/a	n/a
S BIO Pte. Ltd. Curated by ChEMBL					Assay Description Inhibition of recombinant Flt3 using poly(Glu,Tyr) as substrate after 2 hrs by luminescence assay				J Med Chem 55: 169-96 (2012) Checked by Author Article DOI: 10.1021/jm201112g BindingDB Entry DOI: 10.7270/Q2M61KPN
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM50363211 (CHEMBL1947162) Show SMILES C1C\C=C\CNCc2cccc(Nc3nccc(n3)-c3cccc(O1)c3)c2 |t:2| Show InChI InChI=1S/C22H22N4O/c1-2-11-23-16-17-6-4-8-19(14-17)25-22-24-12-10-21(26-22)18-7-5-9-20(15-18)27-13-3-1/h1-2,4-10,12,14-15,23H,3,11,13,16H2,(H,24,25,26)/b2-1+	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	110	n/a	n/a	n/a	n/a	n/a	n/a
S BIO Pte. Ltd. Curated by ChEMBL					Assay Description Inhibition of recombinant Flt3 using poly(Glu,Tyr) as substrate after 2 hrs by luminescence assay				J Med Chem 55: 169-96 (2012) Checked by Author Article DOI: 10.1021/jm201112g BindingDB Entry DOI: 10.7270/Q2M61KPN
					More data for this Ligand-Target Pair
Cyclin-A2/Cyclin-dependent kinase 2 (Homo sapiens (Human))	BDBM50363224 (CHEMBL1945565) Show SMILES COCCOc1ccc2Nc3nccc(n3)-c3cccc(OCC\C=C\CN(C)Cc1c2)c3 |t:25| Show InChI InChI=1S/C26H30N4O3/c1-30-13-4-3-5-14-32-23-8-6-7-20(18-23)24-11-12-27-26(29-24)28-22-9-10-25(21(17-22)19-30)33-16-15-31-2/h3-4,6-12,17-18H,5,13-16,19H2,1-2H3,(H,27,28,29)/b4-3+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	110	n/a	n/a	n/a	n/a	n/a	n/a
S BIO Pte. Ltd. Curated by ChEMBL					Assay Description Inhibition of recombinant Cdk2/cyclin A using RbING as substrate after 2 hrs by luminescence assay				J Med Chem 55: 169-96 (2012) Checked by Author Article DOI: 10.1021/jm201112g BindingDB Entry DOI: 10.7270/Q2M61KPN
					More data for this Ligand-Target Pair

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