Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human)) | BDBM50300690 (1-(5-Tert-Butyl-1,2-Oxazol-3-Yl)-3-(4-{7-[2-(Morph...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a | n/a |
High Magnetic Field Laboratory, Chinese Academy of Sciences , Mailbox 1110, 350 Shushanhu Road, Hefei, Anhui 230031, P. R. China. Curated by ChEMBL | Assay Description Inhibition of human HL60 cells-derived His-tagged FLT3 (564 to 993 residues) expressed in baculovirus infected sf9 cells using poly (4:1 Glu, Tyr) as... | J Med Chem 60: 8407-8424 (2017) Article DOI: 10.1021/acs.jmedchem.7b00840 BindingDB Entry DOI: 10.7270/Q2474D9S | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human)) | BDBM50250180 (CHEMBL4101411) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 32 | n/a | n/a | n/a | n/a | n/a | n/a |
High Magnetic Field Laboratory, Chinese Academy of Sciences , Mailbox 1110, 350 Shushanhu Road, Hefei, Anhui 230031, P. R. China. Curated by ChEMBL | Assay Description Inhibition of RET (unknown origin) using poly (4:1 Glu, Tyr) as substrate after 1 hr by ADP-Glo kinase assay | J Med Chem 60: 8407-8424 (2017) Article DOI: 10.1021/acs.jmedchem.7b00840 BindingDB Entry DOI: 10.7270/Q2474D9S | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-dependent kinase 11B (Homo sapiens (Human)) | BDBM50250180 (CHEMBL4101411) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 36 | n/a | n/a | n/a | n/a | n/a | n/a |
High Magnetic Field Laboratory, Chinese Academy of Sciences , Mailbox 1110, 350 Shushanhu Road, Hefei, Anhui 230031, P. R. China. Curated by ChEMBL | Assay Description Inhibition of human GST-tagged CDK11 by Z'Lyte assay | J Med Chem 60: 8407-8424 (2017) Article DOI: 10.1021/acs.jmedchem.7b00840 BindingDB Entry DOI: 10.7270/Q2474D9S | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-C/Cyclin-dependent kinase 8 (Homo sapiens (Human)) | BDBM50250180 (CHEMBL4101411) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 48 | n/a | n/a | n/a | n/a | n/a | n/a |
High Magnetic Field Laboratory, Chinese Academy of Sciences , Mailbox 1110, 350 Shushanhu Road, Hefei, Anhui 230031, P. R. China. Curated by ChEMBL | Assay Description Inhibition of full length recombinant human His-tagged CDK8/Cyclin C expressed in Baculovirus expression system by Z'Lyte assay | J Med Chem 60: 8407-8424 (2017) Article DOI: 10.1021/acs.jmedchem.7b00840 BindingDB Entry DOI: 10.7270/Q2474D9S | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Discoidin domain-containing receptor 2 (Homo sapiens (Human)) | BDBM50250180 (CHEMBL4101411) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 61 | n/a | n/a | n/a | n/a | n/a | n/a |
High Magnetic Field Laboratory, Chinese Academy of Sciences , Mailbox 1110, 350 Shushanhu Road, Hefei, Anhui 230031, P. R. China. Curated by ChEMBL | Assay Description Inhibition of GST-tagged human DDR2 (427 to 855 residues) expressed in Baculovirus expression system by Z'Lyte assay | J Med Chem 60: 8407-8424 (2017) Article DOI: 10.1021/acs.jmedchem.7b00840 BindingDB Entry DOI: 10.7270/Q2474D9S | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
MAP kinase-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human)) | BDBM50250180 (CHEMBL4101411) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 61 | n/a | n/a | n/a | n/a | n/a | n/a |
High Magnetic Field Laboratory, Chinese Academy of Sciences , Mailbox 1110, 350 Shushanhu Road, Hefei, Anhui 230031, P. R. China. Curated by ChEMBL | Assay Description Inhibition of full length recombinant human GST-tagged MKNK2 expressed in Baculovirus expression system by Z'Lyte assay | J Med Chem 60: 8407-8424 (2017) Article DOI: 10.1021/acs.jmedchem.7b00840 BindingDB Entry DOI: 10.7270/Q2474D9S | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epithelial discoidin domain-containing receptor 1 (Homo sapiens (Human)) | BDBM50250180 (CHEMBL4101411) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 63 | n/a | n/a | n/a | n/a | n/a | n/a |
High Magnetic Field Laboratory, Chinese Academy of Sciences , Mailbox 1110, 350 Shushanhu Road, Hefei, Anhui 230031, P. R. China. Curated by ChEMBL | Assay Description Inhibition of GST-tagged human DDR1 (440 to 876 residues) expressed in Baculovirus expression system by Z'Lyte assay | J Med Chem 60: 8407-8424 (2017) Article DOI: 10.1021/acs.jmedchem.7b00840 BindingDB Entry DOI: 10.7270/Q2474D9S | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mast/stem cell growth factor receptor Kit (Homo sapiens (Human)) | BDBM50250180 (CHEMBL4101411) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 83 | n/a | n/a | n/a | n/a | n/a | n/a |
High Magnetic Field Laboratory, Chinese Academy of Sciences , Mailbox 1110, 350 Shushanhu Road, Hefei, Anhui 230031, P. R. China. Curated by ChEMBL | Assay Description Inhibition of cKIT (unknown origin) using poly (4:1 Glu, Tyr) as substrate after 1 hr by ADP-Glo kinase assay | J Med Chem 60: 8407-8424 (2017) Article DOI: 10.1021/acs.jmedchem.7b00840 BindingDB Entry DOI: 10.7270/Q2474D9S | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human)) | BDBM50250180 (CHEMBL4101411) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 91 | n/a | n/a | n/a | n/a | n/a | n/a |
High Magnetic Field Laboratory, Chinese Academy of Sciences , Mailbox 1110, 350 Shushanhu Road, Hefei, Anhui 230031, P. R. China. Curated by ChEMBL | Assay Description Inhibition of human HL60 cells-derived His-tagged FLT3 (564 to 993 residues) expressed in baculovirus infected sf9 cells using poly (4:1 Glu, Tyr) as... | J Med Chem 60: 8407-8424 (2017) Article DOI: 10.1021/acs.jmedchem.7b00840 BindingDB Entry DOI: 10.7270/Q2474D9S | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase BTK (Homo sapiens (Human)) | BDBM50250180 (CHEMBL4101411) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 95 | n/a | n/a | n/a | n/a | n/a | n/a |
High Magnetic Field Laboratory, Chinese Academy of Sciences , Mailbox 1110, 350 Shushanhu Road, Hefei, Anhui 230031, P. R. China. Curated by ChEMBL | Assay Description Inhibition of BTK (unknown origin) using poly (4:1 Glu, Tyr) as substrate after 1 hr by ADP-Glo kinase assay | J Med Chem 60: 8407-8424 (2017) Article DOI: 10.1021/acs.jmedchem.7b00840 BindingDB Entry DOI: 10.7270/Q2474D9S | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Vascular endothelial growth factor receptor 3 (Homo sapiens (Human)) | BDBM50250180 (CHEMBL4101411) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 141 | n/a | n/a | n/a | n/a | n/a | n/a |
High Magnetic Field Laboratory, Chinese Academy of Sciences , Mailbox 1110, 350 Shushanhu Road, Hefei, Anhui 230031, P. R. China. Curated by ChEMBL | Assay Description Binding affinity to FLT4 (unknown origin) by KinomeSCan assay | J Med Chem 60: 8407-8424 (2017) Article DOI: 10.1021/acs.jmedchem.7b00840 BindingDB Entry DOI: 10.7270/Q2474D9S | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Macrophage colony-stimulating factor 1 receptor (Homo sapiens (Human)) | BDBM50250180 (CHEMBL4101411) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 154 | n/a | n/a | n/a | n/a | n/a | n/a |
High Magnetic Field Laboratory, Chinese Academy of Sciences , Mailbox 1110, 350 Shushanhu Road, Hefei, Anhui 230031, P. R. China. Curated by ChEMBL | Assay Description Inhibition of recombinant human His-tagged CSF1R (538 to 910 residues) expressed in Baculovirus expression system by Z'Lyte assay | J Med Chem 60: 8407-8424 (2017) Article DOI: 10.1021/acs.jmedchem.7b00840 BindingDB Entry DOI: 10.7270/Q2474D9S | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase Lck (Homo sapiens (Human)) | BDBM50250180 (CHEMBL4101411) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 425 | n/a | n/a | n/a | n/a | n/a | n/a |
High Magnetic Field Laboratory, Chinese Academy of Sciences , Mailbox 1110, 350 Shushanhu Road, Hefei, Anhui 230031, P. R. China. Curated by ChEMBL | Assay Description Inhibition of full length recombinant human His-tagged LCK expressed in Baculovirus expression system by Z'Lyte assay | J Med Chem 60: 8407-8424 (2017) Article DOI: 10.1021/acs.jmedchem.7b00840 BindingDB Entry DOI: 10.7270/Q2474D9S | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Platelet-derived growth factor receptor alpha (Homo sapiens (Human)) | BDBM50250180 (CHEMBL4101411) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 426 | n/a | n/a | n/a | n/a | n/a | n/a |
High Magnetic Field Laboratory, Chinese Academy of Sciences , Mailbox 1110, 350 Shushanhu Road, Hefei, Anhui 230031, P. R. China. Curated by ChEMBL | Assay Description Binding affinity to PDGFRalpha (unknown origin) by KinomeSCan assay | J Med Chem 60: 8407-8424 (2017) Article DOI: 10.1021/acs.jmedchem.7b00840 BindingDB Entry DOI: 10.7270/Q2474D9S | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Platelet-derived growth factor receptor beta (Homo sapiens (Human)) | BDBM50250180 (CHEMBL4101411) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 606 | n/a | n/a | n/a | n/a | n/a | n/a |
High Magnetic Field Laboratory, Chinese Academy of Sciences , Mailbox 1110, 350 Shushanhu Road, Hefei, Anhui 230031, P. R. China. Curated by ChEMBL | Assay Description Binding affinity to PDGFRbeta (unknown origin) by KinomeSCan assay | J Med Chem 60: 8407-8424 (2017) Article DOI: 10.1021/acs.jmedchem.7b00840 BindingDB Entry DOI: 10.7270/Q2474D9S | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
CDK-activating kinase assembly factor MAT1/Cyclin-H/Cyclin-dependent kinase 7 (Homo sapiens (Human)) | BDBM50250180 (CHEMBL4101411) | PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
High Magnetic Field Laboratory, Chinese Academy of Sciences , Mailbox 1110, 350 Shushanhu Road, Hefei, Anhui 230031, P. R. China. Curated by ChEMBL | Assay Description Inhibition of full length recombinant human His-tagged CDK7/Cyclin H/MNAT1 expressed in Baculovirus expression system by Z'Lyte assay | J Med Chem 60: 8407-8424 (2017) Article DOI: 10.1021/acs.jmedchem.7b00840 BindingDB Entry DOI: 10.7270/Q2474D9S | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human)) | BDBM50250180 (CHEMBL4101411) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | <10 | n/a | n/a | n/a | n/a |
High Magnetic Field Laboratory, Chinese Academy of Sciences , Mailbox 1110, 350 Shushanhu Road, Hefei, Anhui 230031, P. R. China. Curated by ChEMBL | Assay Description Inhibition of FLT3 in human MOLM14 cells assessed as inhibition of STAT5 phosphorylation at Tyr694 site after 4 hrs by immunoblotting analysis | J Med Chem 60: 8407-8424 (2017) Article DOI: 10.1021/acs.jmedchem.7b00840 BindingDB Entry DOI: 10.7270/Q2474D9S | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human)) | BDBM50250180 (CHEMBL4101411) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | <10 | n/a | n/a | n/a | n/a |
High Magnetic Field Laboratory, Chinese Academy of Sciences , Mailbox 1110, 350 Shushanhu Road, Hefei, Anhui 230031, P. R. China. Curated by ChEMBL | Assay Description Inhibition of FLT3 in human MOLM13 cells assessed as inhibition of Akt phosphorylation at Thr308/Ser473 site after 4 hrs by immunoblotting analysis | J Med Chem 60: 8407-8424 (2017) Article DOI: 10.1021/acs.jmedchem.7b00840 BindingDB Entry DOI: 10.7270/Q2474D9S | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human)) | BDBM50250180 (CHEMBL4101411) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | <10 | n/a | n/a | n/a | n/a |
High Magnetic Field Laboratory, Chinese Academy of Sciences , Mailbox 1110, 350 Shushanhu Road, Hefei, Anhui 230031, P. R. China. Curated by ChEMBL | Assay Description Inhibition of FLT3 in human MOLM4 cells assessed as inhibition of ERK phosphorylation at Thr202/Tyr204 site after 4 hrs by immunoblotting analysis | J Med Chem 60: 8407-8424 (2017) Article DOI: 10.1021/acs.jmedchem.7b00840 BindingDB Entry DOI: 10.7270/Q2474D9S | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Platelet-derived growth factor receptor alpha (Homo sapiens (Human)) | BDBM50300690 (1-(5-Tert-Butyl-1,2-Oxazol-3-Yl)-3-(4-{7-[2-(Morph...) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a |
High Magnetic Field Laboratory, Chinese Academy of Sciences , Mailbox 1110, 350 Shushanhu Road, Hefei, Anhui 230031, P. R. China. Curated by ChEMBL | Assay Description Binding affinity to PDGFRalpha (unknown origin) by KinomeSCan assay | J Med Chem 60: 8407-8424 (2017) Article DOI: 10.1021/acs.jmedchem.7b00840 BindingDB Entry DOI: 10.7270/Q2474D9S | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Vascular endothelial growth factor receptor 3 (Homo sapiens (Human)) | BDBM50300690 (1-(5-Tert-Butyl-1,2-Oxazol-3-Yl)-3-(4-{7-[2-(Morph...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | 41 | n/a | n/a | n/a | n/a | n/a |
High Magnetic Field Laboratory, Chinese Academy of Sciences , Mailbox 1110, 350 Shushanhu Road, Hefei, Anhui 230031, P. R. China. Curated by ChEMBL | Assay Description Binding affinity to FLT4 (unknown origin) by KinomeSCan assay | J Med Chem 60: 8407-8424 (2017) Article DOI: 10.1021/acs.jmedchem.7b00840 BindingDB Entry DOI: 10.7270/Q2474D9S | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epithelial discoidin domain-containing receptor 1 (Homo sapiens (Human)) | BDBM50300690 (1-(5-Tert-Butyl-1,2-Oxazol-3-Yl)-3-(4-{7-[2-(Morph...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | 81 | n/a | n/a | n/a | n/a | n/a |
High Magnetic Field Laboratory, Chinese Academy of Sciences , Mailbox 1110, 350 Shushanhu Road, Hefei, Anhui 230031, P. R. China. Curated by ChEMBL | Assay Description Binding affinity to DDR1 (unknown origin) by KinomeSCan assay | J Med Chem 60: 8407-8424 (2017) Article DOI: 10.1021/acs.jmedchem.7b00840 BindingDB Entry DOI: 10.7270/Q2474D9S | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human)) | BDBM50250180 (CHEMBL4101411) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | <10 | n/a | n/a | n/a | n/a |
High Magnetic Field Laboratory, Chinese Academy of Sciences , Mailbox 1110, 350 Shushanhu Road, Hefei, Anhui 230031, P. R. China. Curated by ChEMBL | Assay Description Inhibition of FLT3 in human MV4-11 cells assessed as inhibition of ERK phosphorylation at Thr202/Tyr204 site after 4 hrs by immunoblotting analysis | J Med Chem 60: 8407-8424 (2017) Article DOI: 10.1021/acs.jmedchem.7b00840 BindingDB Entry DOI: 10.7270/Q2474D9S | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Vascular endothelial growth factor receptor 1 (Homo sapiens (Human)) | BDBM50300690 (1-(5-Tert-Butyl-1,2-Oxazol-3-Yl)-3-(4-{7-[2-(Morph...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | 41 | n/a | n/a | n/a | n/a | n/a |
High Magnetic Field Laboratory, Chinese Academy of Sciences , Mailbox 1110, 350 Shushanhu Road, Hefei, Anhui 230031, P. R. China. Curated by ChEMBL | Assay Description Binding affinity to FLT1 (unknown origin) by KinomeSCan assay | J Med Chem 60: 8407-8424 (2017) Article DOI: 10.1021/acs.jmedchem.7b00840 BindingDB Entry DOI: 10.7270/Q2474D9S | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human)) | BDBM50300690 (1-(5-Tert-Butyl-1,2-Oxazol-3-Yl)-3-(4-{7-[2-(Morph...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | 9.90 | n/a | n/a | n/a | n/a | n/a |
High Magnetic Field Laboratory, Chinese Academy of Sciences , Mailbox 1110, 350 Shushanhu Road, Hefei, Anhui 230031, P. R. China. Curated by ChEMBL | Assay Description Inhibition of RET (unknown origin) using poly (4:1 Glu, Tyr) as substrate after 1 hr by ADP-Glo kinase assay | J Med Chem 60: 8407-8424 (2017) Article DOI: 10.1021/acs.jmedchem.7b00840 BindingDB Entry DOI: 10.7270/Q2474D9S | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Discoidin domain-containing receptor 2 (Homo sapiens (Human)) | BDBM50300690 (1-(5-Tert-Butyl-1,2-Oxazol-3-Yl)-3-(4-{7-[2-(Morph...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | 690 | n/a | n/a | n/a | n/a | n/a |
High Magnetic Field Laboratory, Chinese Academy of Sciences , Mailbox 1110, 350 Shushanhu Road, Hefei, Anhui 230031, P. R. China. Curated by ChEMBL | Assay Description Binding affinity to DDR2 (unknown origin) by KinomeSCan assay | J Med Chem 60: 8407-8424 (2017) Article DOI: 10.1021/acs.jmedchem.7b00840 BindingDB Entry DOI: 10.7270/Q2474D9S | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Macrophage colony-stimulating factor 1 receptor (Homo sapiens (Human)) | BDBM50300690 (1-(5-Tert-Butyl-1,2-Oxazol-3-Yl)-3-(4-{7-[2-(Morph...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a |
High Magnetic Field Laboratory, Chinese Academy of Sciences , Mailbox 1110, 350 Shushanhu Road, Hefei, Anhui 230031, P. R. China. Curated by ChEMBL | Assay Description Binding affinity to CSF1R (unknown origin) by KinomeSCan assay | J Med Chem 60: 8407-8424 (2017) Article DOI: 10.1021/acs.jmedchem.7b00840 BindingDB Entry DOI: 10.7270/Q2474D9S | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mast/stem cell growth factor receptor Kit (Homo sapiens (Human)) | BDBM50300690 (1-(5-Tert-Butyl-1,2-Oxazol-3-Yl)-3-(4-{7-[2-(Morph...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | 4.80 | n/a | n/a | n/a | n/a | n/a |
High Magnetic Field Laboratory, Chinese Academy of Sciences , Mailbox 1110, 350 Shushanhu Road, Hefei, Anhui 230031, P. R. China. Curated by ChEMBL | Assay Description Binding affinity to KIT (unknown origin) by KinomeSCan assay | J Med Chem 60: 8407-8424 (2017) Article DOI: 10.1021/acs.jmedchem.7b00840 BindingDB Entry DOI: 10.7270/Q2474D9S | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Platelet-derived growth factor receptor beta (Homo sapiens (Human)) | BDBM50300690 (1-(5-Tert-Butyl-1,2-Oxazol-3-Yl)-3-(4-{7-[2-(Morph...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | 7.70 | n/a | n/a | n/a | n/a | n/a |
High Magnetic Field Laboratory, Chinese Academy of Sciences , Mailbox 1110, 350 Shushanhu Road, Hefei, Anhui 230031, P. R. China. Curated by ChEMBL | Assay Description Binding affinity to PDGFRbeta (unknown origin) by KinomeSCan assay | J Med Chem 60: 8407-8424 (2017) Article DOI: 10.1021/acs.jmedchem.7b00840 BindingDB Entry DOI: 10.7270/Q2474D9S | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human)) | BDBM50250180 (CHEMBL4101411) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | <10 | n/a | n/a | n/a | n/a |
High Magnetic Field Laboratory, Chinese Academy of Sciences , Mailbox 1110, 350 Shushanhu Road, Hefei, Anhui 230031, P. R. China. Curated by ChEMBL | Assay Description Inhibition of FLT3 in human MOLM13 cells assessed as inhibition of STAT5 phosphorylation at Tyr694 site after 4 hrs by immunoblotting analysis | J Med Chem 60: 8407-8424 (2017) Article DOI: 10.1021/acs.jmedchem.7b00840 BindingDB Entry DOI: 10.7270/Q2474D9S | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human)) | BDBM50250180 (CHEMBL4101411) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | <10 | n/a | n/a | n/a | n/a |
High Magnetic Field Laboratory, Chinese Academy of Sciences , Mailbox 1110, 350 Shushanhu Road, Hefei, Anhui 230031, P. R. China. Curated by ChEMBL | Assay Description Inhibition of FLT3 in human MV4-11 cells assessed as inhibition of Akt phosphorylation at Thr308/Ser473 site after 4 hrs by immunoblotting analysis | J Med Chem 60: 8407-8424 (2017) Article DOI: 10.1021/acs.jmedchem.7b00840 BindingDB Entry DOI: 10.7270/Q2474D9S | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human)) | BDBM50250180 (CHEMBL4101411) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | <10 | n/a | n/a | n/a | n/a |
High Magnetic Field Laboratory, Chinese Academy of Sciences , Mailbox 1110, 350 Shushanhu Road, Hefei, Anhui 230031, P. R. China. Curated by ChEMBL | Assay Description Inhibition of FLT3 in human MV4-11 cells assessed as inhibition of STAT5 phosphorylation at Tyr694 site after 4 hrs by immunoblotting analysis | J Med Chem 60: 8407-8424 (2017) Article DOI: 10.1021/acs.jmedchem.7b00840 BindingDB Entry DOI: 10.7270/Q2474D9S | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human)) | BDBM50250180 (CHEMBL4101411) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | <10 | n/a | n/a | n/a | n/a |
High Magnetic Field Laboratory, Chinese Academy of Sciences , Mailbox 1110, 350 Shushanhu Road, Hefei, Anhui 230031, P. R. China. Curated by ChEMBL | Assay Description Inhibition of FLT3 in human MOLM14 cells assessed as inhibition of Akt phosphorylation at Thr308/Ser473 site after 4 hrs by immunoblotting analysis | J Med Chem 60: 8407-8424 (2017) Article DOI: 10.1021/acs.jmedchem.7b00840 BindingDB Entry DOI: 10.7270/Q2474D9S | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human)) | BDBM50250180 (CHEMBL4101411) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | <10 | n/a | n/a | n/a | n/a |
High Magnetic Field Laboratory, Chinese Academy of Sciences , Mailbox 1110, 350 Shushanhu Road, Hefei, Anhui 230031, P. R. China. Curated by ChEMBL | Assay Description Inhibition of FLT3 in human MOLM13 cells assessed as inhibition of ERK phosphorylation at Thr202/Tyr204 site after 4 hrs by immunoblotting analysis | J Med Chem 60: 8407-8424 (2017) Article DOI: 10.1021/acs.jmedchem.7b00840 BindingDB Entry DOI: 10.7270/Q2474D9S | |||||||||||
More data for this Ligand-Target Pair |