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Compile Data Set for Download or QSAR

Found 25 hits Enz. Inhib. hit(s) with all data for entry = 50001281   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM50044287
PNG
(CHEMBL3356900)
Show SMILES CCCn1cnc(CCNC(=O)Nc2nc3ccc(cc3s2)-c2cncc(OC)c2)c1
Show InChI InChI=1S/C22H24N6O2S/c1-3-8-28-13-17(25-14-28)6-7-24-21(29)27-22-26-19-5-4-15(10-20(19)31-22)16-9-18(30-2)12-23-11-16/h4-5,9-14H,3,6-8H2,1-2H3,(H2,24,26,27,29)
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2n/an/an/an/an/an/an/an/a



Vertex Pharmaceuticals Inc

Curated by ChEMBL


Assay Description
Inhibition of PI3Kgamma (unknown origin) using PIP2 as substrate after 15 mins in presence of [33P-ATP] by liquid scintillation counting method


J Med Chem 61: 5245-5256 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00085
BindingDB Entry DOI: 10.7270/Q2V98BK8
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM50274571
PNG
(CHEMBL4127784)
Show SMILES COc1cc(cnc1OC)-c1ccc2C(=O)N(Cc2n1)c1cnn(CC#N)c1
Show InChI InChI=1S/C19H16N6O3/c1-27-17-7-12(8-21-18(17)28-2)15-4-3-14-16(23-15)11-25(19(14)26)13-9-22-24(10-13)6-5-20/h3-4,7-10H,6,11H2,1-2H3
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3n/an/an/an/an/an/an/an/a



Vertex Pharmaceuticals Inc

Curated by ChEMBL


Assay Description
Inhibition of PI3Kgamma (unknown origin) using PIP2 as substrate after 15 mins in presence of [33P-ATP] by liquid scintillation counting method


J Med Chem 61: 5245-5256 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00085
BindingDB Entry DOI: 10.7270/Q2V98BK8
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM50274537
PNG
(CHEMBL4129974)
Show SMILES COc1cc(cnc1OC)-c1ccc2C(=O)N(Cc2n1)c1cnn(CC(F)(F)F)c1
Show InChI InChI=1S/C19H16F3N5O3/c1-29-16-5-11(6-23-17(16)30-2)14-4-3-13-15(25-14)9-27(18(13)28)12-7-24-26(8-12)10-19(20,21)22/h3-8H,9-10H2,1-2H3
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4n/an/an/an/an/an/an/an/a



Vertex Pharmaceuticals Inc

Curated by ChEMBL


Assay Description
Inhibition of PI3Kgamma (unknown origin) using PIP2 as substrate after 15 mins in presence of [33P-ATP] by liquid scintillation counting method


J Med Chem 61: 5245-5256 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00085
BindingDB Entry DOI: 10.7270/Q2V98BK8
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM50274538
PNG
(CHEMBL4126773)
Show SMILES COc1cc(cnc1OC)-c1ccc2C(=O)N([C@H](C)c2n1)c1cnn(CC(F)(F)F)c1 |r|
Show InChI InChI=1S/C20H18F3N5O3/c1-11-17-14(19(29)28(11)13-8-25-27(9-13)10-20(21,22)23)4-5-15(26-17)12-6-16(30-2)18(31-3)24-7-12/h4-9,11H,10H2,1-3H3/t11-/m1/s1
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4n/an/an/an/an/an/an/an/a



Vertex Pharmaceuticals Inc

Curated by ChEMBL


Assay Description
Inhibition of PI3Kgamma (unknown origin) using PIP2 as substrate after 15 mins in presence of [33P-ATP] by liquid scintillation counting method


J Med Chem 61: 5245-5256 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00085
BindingDB Entry DOI: 10.7270/Q2V98BK8
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM50274572
PNG
(CHEMBL4129180)
Show SMILES COc1cc(cnc1OC)-c1ccc2C(=O)N(Cc2c1)c1cnn(CC#N)c1
Show InChI InChI=1S/C20H17N5O3/c1-27-18-8-14(9-22-19(18)28-2)13-3-4-17-15(7-13)11-25(20(17)26)16-10-23-24(12-16)6-5-21/h3-4,7-10,12H,6,11H2,1-2H3
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6n/an/an/an/an/an/an/an/a



Vertex Pharmaceuticals Inc

Curated by ChEMBL


Assay Description
Inhibition of PI3Kgamma (unknown origin) using PIP2 as substrate after 15 mins in presence of [33P-ATP] by liquid scintillation counting method


J Med Chem 61: 5245-5256 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00085
BindingDB Entry DOI: 10.7270/Q2V98BK8
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM50274541
PNG
(CHEMBL4130036)
Show SMILES COc1cc(cnc1OC)-c1ccc2C(=O)N([C@@H](C)c2n1)c1cnn(CC(F)(F)F)c1 |r|
Show InChI InChI=1S/C20H18F3N5O3/c1-11-17-14(19(29)28(11)13-8-25-27(9-13)10-20(21,22)23)4-5-15(26-17)12-6-16(30-2)18(31-3)24-7-12/h4-9,11H,10H2,1-3H3/t11-/m0/s1
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7n/an/an/an/an/an/an/an/a



Vertex Pharmaceuticals Inc

Curated by ChEMBL


Assay Description
Inhibition of PI3Kgamma (unknown origin) using PIP2 as substrate after 15 mins in presence of [33P-ATP] by liquid scintillation counting method


J Med Chem 61: 5245-5256 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00085
BindingDB Entry DOI: 10.7270/Q2V98BK8
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM50274559
PNG
(CHEMBL4126707)
Show SMILES CCn1cc(cn1)N1Cc2nc(ccc2C1=O)-c1cnc(OC)c(OC)c1
Show InChI InChI=1S/C19H19N5O3/c1-4-23-10-13(9-21-23)24-11-16-14(19(24)25)5-6-15(22-16)12-7-17(26-2)18(27-3)20-8-12/h5-10H,4,11H2,1-3H3
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8n/an/an/an/an/an/an/an/a



Vertex Pharmaceuticals Inc

Curated by ChEMBL


Assay Description
Inhibition of PI3Kgamma (unknown origin) using PIP2 as substrate after 15 mins in presence of [33P-ATP] by liquid scintillation counting method


J Med Chem 61: 5245-5256 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00085
BindingDB Entry DOI: 10.7270/Q2V98BK8
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM50274542
PNG
(CHEMBL4127853)
Show SMILES COc1cc(cnc1OC)-c1ccc2C(=O)N(Cc2n1)c1cnn(CC#C)c1
Show InChI InChI=1S/C20H17N5O3/c1-4-7-24-11-14(10-22-24)25-12-17-15(20(25)26)5-6-16(23-17)13-8-18(27-2)19(28-3)21-9-13/h1,5-6,8-11H,7,12H2,2-3H3
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9n/an/an/an/an/an/an/an/a



Vertex Pharmaceuticals Inc

Curated by ChEMBL


Assay Description
Inhibition of PI3Kgamma (unknown origin) using PIP2 as substrate after 15 mins in presence of [33P-ATP] by liquid scintillation counting method


J Med Chem 61: 5245-5256 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00085
BindingDB Entry DOI: 10.7270/Q2V98BK8
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM50274543
PNG
(CHEMBL4129251)
Show SMILES COc1cc(cnc1OC)-c1ccc2C(=O)N(Cc2n1)c1cnn(CC(F)F)c1
Show InChI InChI=1S/C19H17F2N5O3/c1-28-16-5-11(6-22-18(16)29-2)14-4-3-13-15(24-14)9-26(19(13)27)12-7-23-25(8-12)10-17(20)21/h3-8,17H,9-10H2,1-2H3
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9n/an/an/an/an/an/an/an/a



Vertex Pharmaceuticals Inc

Curated by ChEMBL


Assay Description
Inhibition of PI3Kgamma (unknown origin) using PIP2 as substrate after 15 mins in presence of [33P-ATP] by liquid scintillation counting method


J Med Chem 61: 5245-5256 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00085
BindingDB Entry DOI: 10.7270/Q2V98BK8
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM50274540
PNG
(CHEMBL4128822)
Show SMILES COc1cc(cnc1OC)-c1ccc2C(=O)N(c3cnn(CC(F)(F)F)c3)C(C)(C)c2n1
Show InChI InChI=1S/C21H20F3N5O3/c1-20(2)17-14(19(30)29(20)13-9-26-28(10-13)11-21(22,23)24)5-6-15(27-17)12-7-16(31-3)18(32-4)25-8-12/h5-10H,11H2,1-4H3
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11n/an/an/an/an/an/an/an/a



Vertex Pharmaceuticals Inc

Curated by ChEMBL


Assay Description
Inhibition of PI3Kgamma (unknown origin) using PIP2 as substrate after 15 mins in presence of [33P-ATP] by liquid scintillation counting method


J Med Chem 61: 5245-5256 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00085
BindingDB Entry DOI: 10.7270/Q2V98BK8
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM50274560
PNG
(CHEMBL4125738)
Show SMILES COc1cc(cnc1OC)-c1ccc2C(=O)N(Cc2n1)c1cn[nH]c1
Show InChI InChI=1S/C17H15N5O3/c1-24-15-5-10(6-18-16(15)25-2)13-4-3-12-14(21-13)9-22(17(12)23)11-7-19-20-8-11/h3-8H,9H2,1-2H3,(H,19,20)
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11n/an/an/an/an/an/an/an/a



Vertex Pharmaceuticals Inc

Curated by ChEMBL


Assay Description
Inhibition of PI3Kgamma (unknown origin) using PIP2 as substrate after 15 mins in presence of [33P-ATP] by liquid scintillation counting method


J Med Chem 61: 5245-5256 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00085
BindingDB Entry DOI: 10.7270/Q2V98BK8
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM50274580
PNG
(CHEMBL4128006)
Show SMILES COc1cc(cnc1OC)-c1ccc2C(=O)N(Cc2n1)c1cnn(CCC#N)c1
Show InChI InChI=1S/C20H18N6O3/c1-28-18-8-13(9-22-19(18)29-2)16-5-4-15-17(24-16)12-26(20(15)27)14-10-23-25(11-14)7-3-6-21/h4-5,8-11H,3,7,12H2,1-2H3
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20n/an/an/an/an/an/an/an/a



Vertex Pharmaceuticals Inc

Curated by ChEMBL


Assay Description
Inhibition of PI3Kgamma (unknown origin) using PIP2 as substrate after 15 mins in presence of [33P-ATP] by liquid scintillation counting method


J Med Chem 61: 5245-5256 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00085
BindingDB Entry DOI: 10.7270/Q2V98BK8
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM50274544
PNG
(CHEMBL4126620)
Show SMILES COc1cc(cnc1OC)-c1ccc2C(=O)N(Cc2n1)c1cnn(c1)C(C)(C)C#N
Show InChI InChI=1S/C21H20N6O3/c1-21(2,12-22)27-10-14(9-24-27)26-11-17-15(20(26)28)5-6-16(25-17)13-7-18(29-3)19(30-4)23-8-13/h5-10H,11H2,1-4H3
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28n/an/an/an/an/an/an/an/a



Vertex Pharmaceuticals Inc

Curated by ChEMBL


Assay Description
Inhibition of PI3Kgamma (unknown origin) using PIP2 as substrate after 15 mins in presence of [33P-ATP] by liquid scintillation counting method


J Med Chem 61: 5245-5256 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00085
BindingDB Entry DOI: 10.7270/Q2V98BK8
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM50274573
PNG
(CHEMBL4126829)
Show SMILES COc1cc(cnc1OC)-c1ccc2C(=O)N(Cc2c1)c1cccc(CC#N)c1
Show InChI InChI=1S/C23H19N3O3/c1-28-21-12-17(13-25-22(21)29-2)16-6-7-20-18(11-16)14-26(23(20)27)19-5-3-4-15(10-19)8-9-24/h3-7,10-13H,8,14H2,1-2H3
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35n/an/an/an/an/an/an/an/a



Vertex Pharmaceuticals Inc

Curated by ChEMBL


Assay Description
Inhibition of PI3Kgamma (unknown origin) using PIP2 as substrate after 15 mins in presence of [33P-ATP] by liquid scintillation counting method


J Med Chem 61: 5245-5256 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00085
BindingDB Entry DOI: 10.7270/Q2V98BK8
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM50274581
PNG
(CHEMBL4129025)
Show SMILES COc1cc(cnc1OC)-c1ccc2C(=O)N(Cc2n1)c1cnn(C)c1
Show InChI InChI=1S/C18H17N5O3/c1-22-9-12(8-20-22)23-10-15-13(18(23)24)4-5-14(21-15)11-6-16(25-2)17(26-3)19-7-11/h4-9H,10H2,1-3H3
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60n/an/an/an/an/an/an/an/a



Vertex Pharmaceuticals Inc

Curated by ChEMBL


Assay Description
Inhibition of PI3Kgamma (unknown origin) using PIP2 as substrate after 15 mins in presence of [33P-ATP] by liquid scintillation counting method


J Med Chem 61: 5245-5256 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00085
BindingDB Entry DOI: 10.7270/Q2V98BK8
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM50274574
PNG
(CHEMBL4128211)
Show SMILES COc1ccc(cc1OC)-c1ccc2C(=O)N(Cc2c1)c1cccc(CC#N)c1
Show InChI InChI=1S/C24H20N2O3/c1-28-22-9-7-18(14-23(22)29-2)17-6-8-21-19(13-17)15-26(24(21)27)20-5-3-4-16(12-20)10-11-25/h3-9,12-14H,10,15H2,1-2H3
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160n/an/an/an/an/an/an/an/a



Vertex Pharmaceuticals Inc

Curated by ChEMBL


Assay Description
Inhibition of PI3Kgamma (unknown origin) using PIP2 as substrate after 15 mins in presence of [33P-ATP] by liquid scintillation counting method


J Med Chem 61: 5245-5256 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00085
BindingDB Entry DOI: 10.7270/Q2V98BK8
More data for this
Ligand-Target Pair
DNA-dependent protein kinase catalytic subunit


(Homo sapiens (Human))
BDBM50274538
PNG
(CHEMBL4126773)
Show SMILES COc1cc(cnc1OC)-c1ccc2C(=O)N([C@H](C)c2n1)c1cnn(CC(F)(F)F)c1 |r|
Show InChI InChI=1S/C20H18F3N5O3/c1-11-17-14(19(29)28(11)13-8-25-27(9-13)10-20(21,22)23)4-5-15(26-17)12-6-16(30-2)18(31-3)24-7-12/h4-9,11H,10H2,1-3H3/t11-/m1/s1
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260n/an/an/an/an/an/an/an/a



Vertex Pharmaceuticals Inc

Curated by ChEMBL


Assay Description
Inhibition of DNA-PK (unknown origin) using EPPLSQEAFADLWKKK as substrate after 15 mins in presence of [33P-ATP] by radiometric method


J Med Chem 61: 5245-5256 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00085
BindingDB Entry DOI: 10.7270/Q2V98BK8
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM50274538
PNG
(CHEMBL4126773)
Show SMILES COc1cc(cnc1OC)-c1ccc2C(=O)N([C@H](C)c2n1)c1cnn(CC(F)(F)F)c1 |r|
Show InChI InChI=1S/C20H18F3N5O3/c1-11-17-14(19(29)28(11)13-8-25-27(9-13)10-20(21,22)23)4-5-15(26-17)12-6-16(30-2)18(31-3)24-7-12/h4-9,11H,10H2,1-3H3/t11-/m1/s1
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n/an/a 140n/an/an/an/an/an/a



Vertex Pharmaceuticals Inc

Curated by ChEMBL


Assay Description
Inhibition of PI3Kgamma in TNFalpha primed human neutrophils assessed as inhibition of fMLP-induced ROS generation preincubated for 30 to 60 mins fol...


J Med Chem 61: 5245-5256 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00085
BindingDB Entry DOI: 10.7270/Q2V98BK8
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM50274538
PNG
(CHEMBL4126773)
Show SMILES COc1cc(cnc1OC)-c1ccc2C(=O)N([C@H](C)c2n1)c1cnn(CC(F)(F)F)c1 |r|
Show InChI InChI=1S/C20H18F3N5O3/c1-11-17-14(19(29)28(11)13-8-25-27(9-13)10-20(21,22)23)4-5-15(26-17)12-6-16(30-2)18(31-3)24-7-12/h4-9,11H,10H2,1-3H3/t11-/m1/s1
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n/an/a 170n/an/an/an/an/an/a



Vertex Pharmaceuticals Inc

Curated by ChEMBL


Assay Description
Inhibition of PI3Kgamma in human THP1 cells assessed as inhibition of MCP1-induced Akt phosphorylation at Ser-47 residue preincubated for 1 hr follow...


J Med Chem 61: 5245-5256 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00085
BindingDB Entry DOI: 10.7270/Q2V98BK8
More data for this
Ligand-Target Pair
Phosphatidylinositol-4,5-bisphosphate 3-kinase


(Rattus norvegicus)
BDBM50274538
PNG
(CHEMBL4126773)
Show SMILES COc1cc(cnc1OC)-c1ccc2C(=O)N([C@H](C)c2n1)c1cnn(CC(F)(F)F)c1 |r|
Show InChI InChI=1S/C20H18F3N5O3/c1-11-17-14(19(29)28(11)13-8-25-27(9-13)10-20(21,22)23)4-5-15(26-17)12-6-16(30-2)18(31-3)24-7-12/h4-9,11H,10H2,1-3H3/t11-/m1/s1
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n/an/a 210n/an/an/an/an/an/a



Vertex Pharmaceuticals Inc

Curated by ChEMBL


Assay Description
Inhibition of PI3Kgamma in rat spleenocytes assessed as inhibition of MCP1-induced Akt phosphorylation at Ser-47 residue preincubated for 1 hr follow...


J Med Chem 61: 5245-5256 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00085
BindingDB Entry DOI: 10.7270/Q2V98BK8
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM50274541
PNG
(CHEMBL4130036)
Show SMILES COc1cc(cnc1OC)-c1ccc2C(=O)N([C@@H](C)c2n1)c1cnn(CC(F)(F)F)c1 |r|
Show InChI InChI=1S/C20H18F3N5O3/c1-11-17-14(19(29)28(11)13-8-25-27(9-13)10-20(21,22)23)4-5-15(26-17)12-6-16(30-2)18(31-3)24-7-12/h4-9,11H,10H2,1-3H3/t11-/m0/s1
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n/an/a 210n/an/an/an/an/an/a



Vertex Pharmaceuticals Inc

Curated by ChEMBL


Assay Description
Inhibition of PI3Kgamma in human THP1 cells assessed as inhibition of MCP1-induced Akt phosphorylation at Ser-47 residue preincubated for 1 hr follow...


J Med Chem 61: 5245-5256 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00085
BindingDB Entry DOI: 10.7270/Q2V98BK8
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM50274537
PNG
(CHEMBL4129974)
Show SMILES COc1cc(cnc1OC)-c1ccc2C(=O)N(Cc2n1)c1cnn(CC(F)(F)F)c1
Show InChI InChI=1S/C19H16F3N5O3/c1-29-16-5-11(6-23-17(16)30-2)14-4-3-13-15(25-14)9-27(18(13)28)12-7-24-26(8-12)10-19(20,21)22/h3-8H,9-10H2,1-2H3
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n/an/a 280n/an/an/an/an/an/a



Vertex Pharmaceuticals Inc

Curated by ChEMBL


Assay Description
Inhibition of PI3Kgamma in human THP1 cells assessed as inhibition of MCP1-induced Akt phosphorylation at Ser-47 residue preincubated for 1 hr follow...


J Med Chem 61: 5245-5256 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00085
BindingDB Entry DOI: 10.7270/Q2V98BK8
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM50274540
PNG
(CHEMBL4128822)
Show SMILES COc1cc(cnc1OC)-c1ccc2C(=O)N(c3cnn(CC(F)(F)F)c3)C(C)(C)c2n1
Show InChI InChI=1S/C21H20F3N5O3/c1-20(2)17-14(19(30)29(20)13-9-26-28(10-13)11-21(22,23)24)5-6-15(27-17)12-7-16(31-3)18(32-4)25-8-12/h5-10H,11H2,1-4H3
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n/an/a 340n/an/an/an/an/an/a



Vertex Pharmaceuticals Inc

Curated by ChEMBL


Assay Description
Inhibition of PI3Kgamma in human THP1 cells assessed as inhibition of MCP1-induced Akt phosphorylation at Ser-47 residue preincubated for 1 hr follow...


J Med Chem 61: 5245-5256 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00085
BindingDB Entry DOI: 10.7270/Q2V98BK8
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM50274538
PNG
(CHEMBL4126773)
Show SMILES COc1cc(cnc1OC)-c1ccc2C(=O)N([C@H](C)c2n1)c1cnn(CC(F)(F)F)c1 |r|
Show InChI InChI=1S/C20H18F3N5O3/c1-11-17-14(19(29)28(11)13-8-25-27(9-13)10-20(21,22)23)4-5-15(26-17)12-6-16(30-2)18(31-3)24-7-12/h4-9,11H,10H2,1-3H3/t11-/m1/s1
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n/an/a 500n/an/an/an/an/an/a



Vertex Pharmaceuticals Inc

Curated by ChEMBL


Assay Description
Inhibition of PI3Kgamma in TNFalpha primed human whole blood assessed as inhibition of fMLP-induced ROS generation preincubated for 30 to 60 mins fol...


J Med Chem 61: 5245-5256 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00085
BindingDB Entry DOI: 10.7270/Q2V98BK8
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM50274538
PNG
(CHEMBL4126773)
Show SMILES COc1cc(cnc1OC)-c1ccc2C(=O)N([C@H](C)c2n1)c1cnn(CC(F)(F)F)c1 |r|
Show InChI InChI=1S/C20H18F3N5O3/c1-11-17-14(19(29)28(11)13-8-25-27(9-13)10-20(21,22)23)4-5-15(26-17)12-6-16(30-2)18(31-3)24-7-12/h4-9,11H,10H2,1-3H3/t11-/m1/s1
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n/an/a>3.00E+4n/an/an/an/an/an/a



Vertex Pharmaceuticals Inc

Curated by ChEMBL


Assay Description
Inhibition of human ERG


J Med Chem 61: 5245-5256 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00085
BindingDB Entry DOI: 10.7270/Q2V98BK8
More data for this
Ligand-Target Pair