Found 91 hits Enz. Inhib. hit(s) with all data for entry = 50042381 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
cGMP-dependent 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50425140
(CHEMBL2313250)Show SMILES CCNC(=O)c1ccc2nc(C)c3nnc(-c4c(Cl)cccc4Cl)n3c2c1 |(41.13,-18.18,;39.8,-18.95,;38.47,-18.18,;37.13,-18.95,;37.14,-20.49,;35.8,-18.19,;34.46,-18.96,;33.13,-18.19,;33.13,-16.64,;31.79,-15.89,;31.79,-14.35,;30.45,-13.58,;33.12,-13.58,;33.44,-12.07,;34.97,-11.9,;35.6,-13.31,;37.1,-13.63,;38.12,-12.48,;37.64,-11.02,;39.63,-12.79,;40.11,-14.26,;39.08,-15.41,;37.58,-15.09,;36.55,-16.24,;34.45,-14.34,;34.46,-15.87,;35.79,-16.64,)| Show InChI InChI=1S/C19H15Cl2N5O/c1-3-22-19(27)11-7-8-14-15(9-11)26-17(10(2)23-14)24-25-18(26)16-12(20)5-4-6-13(16)21/h4-9H,3H2,1-2H3,(H,22,27) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.280 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen-Cilag S.A.
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PDE2A expressed in Sf9 cells by scintillation proximity assay |
Bioorg Med Chem Lett 23: 785-90 (2013)
Article DOI: 10.1016/j.bmcl.2012.11.077
BindingDB Entry DOI: 10.7270/Q2C82BMR |
More data for this
Ligand-Target Pair | |
cGMP-dependent 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50425132
(CHEMBL2313258)Show SMILES Cc1nc2ccc(cc2n2c(nnc12)-c1ccccc1Cl)C(=O)NCc1ccccc1 Show InChI InChI=1S/C24H18ClN5O/c1-15-22-28-29-23(18-9-5-6-10-19(18)25)30(22)21-13-17(11-12-20(21)27-15)24(31)26-14-16-7-3-2-4-8-16/h2-13H,14H2,1H3,(H,26,31) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.380 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen-Cilag S.A.
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PDE2A expressed in Sf9 cells by scintillation proximity assay |
Bioorg Med Chem Lett 23: 785-90 (2013)
Article DOI: 10.1016/j.bmcl.2012.11.077
BindingDB Entry DOI: 10.7270/Q2C82BMR |
More data for this
Ligand-Target Pair | |
cGMP-dependent 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50425126
(CHEMBL2313231)Show SMILES Cc1nc2ccc(cc2n2c(nnc12)-c1ccccc1Cl)C(=O)NCc1ccccn1 Show InChI InChI=1S/C23H17ClN6O/c1-14-21-28-29-22(17-7-2-3-8-18(17)24)30(21)20-12-15(9-10-19(20)27-14)23(31)26-13-16-6-4-5-11-25-16/h2-12H,13H2,1H3,(H,26,31) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.420 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen-Cilag S.A.
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PDE2A expressed in Sf9 cells by scintillation proximity assay |
Bioorg Med Chem Lett 23: 785-90 (2013)
Article DOI: 10.1016/j.bmcl.2012.11.077
BindingDB Entry DOI: 10.7270/Q2C82BMR |
More data for this
Ligand-Target Pair | |
cGMP-dependent 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50425127
(CHEMBL2313263)Show SMILES Cc1nc2ccc(cc2n2c(nnc12)-c1ccccc1Cl)C(=O)NCCN1CCOCC1 Show InChI InChI=1S/C23H23ClN6O2/c1-15-21-27-28-22(17-4-2-3-5-18(17)24)30(21)20-14-16(6-7-19(20)26-15)23(31)25-8-9-29-10-12-32-13-11-29/h2-7,14H,8-13H2,1H3,(H,25,31) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.470 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen-Cilag S.A.
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PDE2A expressed in Sf9 cells by scintillation proximity assay |
Bioorg Med Chem Lett 23: 785-90 (2013)
Article DOI: 10.1016/j.bmcl.2012.11.077
BindingDB Entry DOI: 10.7270/Q2C82BMR |
More data for this
Ligand-Target Pair | |
cGMP-dependent 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50425143
(CHEMBL2313247 | US11419874, Example 11)Show SMILES CCNC(=O)c1ccc2nc(C)c3nnc(-c4ccccc4Cl)n3c2c1 Show InChI InChI=1S/C19H16ClN5O/c1-3-21-19(26)12-8-9-15-16(10-12)25-17(11(2)22-15)23-24-18(25)13-6-4-5-7-14(13)20/h4-10H,3H2,1-2H3,(H,21,26) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.600 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen-Cilag S.A.
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PDE2A expressed in Sf9 cells by scintillation proximity assay |
Bioorg Med Chem Lett 23: 785-90 (2013)
Article DOI: 10.1016/j.bmcl.2012.11.077
BindingDB Entry DOI: 10.7270/Q2C82BMR |
More data for this
Ligand-Target Pair | |
cGMP-dependent 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50425129
(CHEMBL2313261)Show SMILES CCN(CC)CCNC(=O)c1ccc2nc(C)c3nnc(-c4ccccc4Cl)n3c2c1 Show InChI InChI=1S/C23H25ClN6O/c1-4-29(5-2)13-12-25-23(31)16-10-11-19-20(14-16)30-21(15(3)26-19)27-28-22(30)17-8-6-7-9-18(17)24/h6-11,14H,4-5,12-13H2,1-3H3,(H,25,31) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen-Cilag S.A.
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PDE2A expressed in Sf9 cells by scintillation proximity assay |
Bioorg Med Chem Lett 23: 785-90 (2013)
Article DOI: 10.1016/j.bmcl.2012.11.077
BindingDB Entry DOI: 10.7270/Q2C82BMR |
More data for this
Ligand-Target Pair | |
cGMP-dependent 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50425130
(CHEMBL2313260)Show SMILES Cc1nc2ccc(cc2n2c(nnc12)-c1ccccc1Cl)C(=O)NCCc1ccccc1 Show InChI InChI=1S/C25H20ClN5O/c1-16-23-29-30-24(19-9-5-6-10-20(19)26)31(23)22-15-18(11-12-21(22)28-16)25(32)27-14-13-17-7-3-2-4-8-17/h2-12,15H,13-14H2,1H3,(H,27,32) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen-Cilag S.A.
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PDE2A expressed in Sf9 cells by scintillation proximity assay |
Bioorg Med Chem Lett 23: 785-90 (2013)
Article DOI: 10.1016/j.bmcl.2012.11.077
BindingDB Entry DOI: 10.7270/Q2C82BMR |
More data for this
Ligand-Target Pair | |
cGMP-dependent 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50425128
(CHEMBL2313262)Show SMILES Cc1nc2ccc(cc2n2c(nnc12)-c1ccccc1Cl)C(=O)NCCN1CCCC1 Show InChI InChI=1S/C23H23ClN6O/c1-15-21-27-28-22(17-6-2-3-7-18(17)24)30(21)20-14-16(8-9-19(20)26-15)23(31)25-10-13-29-11-4-5-12-29/h2-3,6-9,14H,4-5,10-13H2,1H3,(H,25,31) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen-Cilag S.A.
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PDE2A expressed in Sf9 cells by scintillation proximity assay |
Bioorg Med Chem Lett 23: 785-90 (2013)
Article DOI: 10.1016/j.bmcl.2012.11.077
BindingDB Entry DOI: 10.7270/Q2C82BMR |
More data for this
Ligand-Target Pair | |
cGMP-dependent 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50425123
(CHEMBL2313234 | US9669035, B-3)Show SMILES Cc1nc2ccc(CN3CCOCC3)cc2n2c(nnc12)-c1ccccc1Cl Show InChI InChI=1S/C21H20ClN5O/c1-14-20-24-25-21(16-4-2-3-5-17(16)22)27(20)19-12-15(6-7-18(19)23-14)13-26-8-10-28-11-9-26/h2-7,12H,8-11,13H2,1H3 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen-Cilag S.A.
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PDE2A expressed in Sf9 cells by scintillation proximity assay |
Bioorg Med Chem Lett 23: 785-90 (2013)
Article DOI: 10.1016/j.bmcl.2012.11.077
BindingDB Entry DOI: 10.7270/Q2C82BMR |
More data for this
Ligand-Target Pair | |
cGMP-dependent 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50425141
(CHEMBL2313249)Show InChI InChI=1S/C19H16FN5O/c1-3-21-19(26)12-8-9-15-16(10-12)25-17(11(2)22-15)23-24-18(25)13-6-4-5-7-14(13)20/h4-10H,3H2,1-2H3,(H,21,26) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen-Cilag S.A.
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PDE2A expressed in Sf9 cells by scintillation proximity assay |
Bioorg Med Chem Lett 23: 785-90 (2013)
Article DOI: 10.1016/j.bmcl.2012.11.077
BindingDB Entry DOI: 10.7270/Q2C82BMR |
More data for this
Ligand-Target Pair | |
cGMP-dependent 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50425145
(CHEMBL2311556)Show SMILES CCOC(=O)c1ccc2nc(C)c3nnc(-c4ccccc4Cl)n3c2c1 Show InChI InChI=1S/C19H15ClN4O2/c1-3-26-19(25)12-8-9-15-16(10-12)24-17(11(2)21-15)22-23-18(24)13-6-4-5-7-14(13)20/h4-10H,3H2,1-2H3 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 4.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen-Cilag S.A.
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PDE2A expressed in Sf9 cells by scintillation proximity assay |
Bioorg Med Chem Lett 23: 785-90 (2013)
Article DOI: 10.1016/j.bmcl.2012.11.077
BindingDB Entry DOI: 10.7270/Q2C82BMR |
More data for this
Ligand-Target Pair | |
cGMP-dependent 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50425118
(CHEMBL2313239)Show SMILES Cc1nc2ccc(CN3CCC(O)C3)cc2n2c(nnc12)-c1ccccc1Cl Show InChI InChI=1S/C21H20ClN5O/c1-13-20-24-25-21(16-4-2-3-5-17(16)22)27(20)19-10-14(6-7-18(19)23-13)11-26-9-8-15(28)12-26/h2-7,10,15,28H,8-9,11-12H2,1H3 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen-Cilag S.A.
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PDE2A expressed in Sf9 cells by scintillation proximity assay |
Bioorg Med Chem Lett 23: 785-90 (2013)
Article DOI: 10.1016/j.bmcl.2012.11.077
BindingDB Entry DOI: 10.7270/Q2C82BMR |
More data for this
Ligand-Target Pair | |
cGMP-dependent 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50425142
(CHEMBL2313248)Show SMILES CCNC(=O)c1ccc2nc(C)c3nnc(-c4ccccc4OC)n3c2c1 Show InChI InChI=1S/C20H19N5O2/c1-4-21-20(26)13-9-10-15-16(11-13)25-18(12(2)22-15)23-24-19(25)14-7-5-6-8-17(14)27-3/h5-11H,4H2,1-3H3,(H,21,26) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 5.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen-Cilag S.A.
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PDE2A expressed in Sf9 cells by scintillation proximity assay |
Bioorg Med Chem Lett 23: 785-90 (2013)
Article DOI: 10.1016/j.bmcl.2012.11.077
BindingDB Entry DOI: 10.7270/Q2C82BMR |
More data for this
Ligand-Target Pair | |
cGMP-dependent 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50425144
(CHEMBL2313246)Show InChI InChI=1S/C19H17N5O/c1-3-20-19(25)14-9-10-15-16(11-14)24-17(12(2)21-15)22-23-18(24)13-7-5-4-6-8-13/h4-11H,3H2,1-2H3,(H,20,25) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 6.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen-Cilag S.A.
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PDE2A expressed in Sf9 cells by scintillation proximity assay |
Bioorg Med Chem Lett 23: 785-90 (2013)
Article DOI: 10.1016/j.bmcl.2012.11.077
BindingDB Entry DOI: 10.7270/Q2C82BMR |
More data for this
Ligand-Target Pair | |
cGMP-dependent 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50425115
(CHEMBL2313242)Show SMILES Cc1nc2ccc(CN3CCCC(O)C3)cc2n2c(nnc12)-c1ccccc1Cl Show InChI InChI=1S/C22H22ClN5O/c1-14-21-25-26-22(17-6-2-3-7-18(17)23)28(21)20-11-15(8-9-19(20)24-14)12-27-10-4-5-16(29)13-27/h2-3,6-9,11,16,29H,4-5,10,12-13H2,1H3 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 6.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen-Cilag S.A.
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PDE2A expressed in Sf9 cells by scintillation proximity assay |
Bioorg Med Chem Lett 23: 785-90 (2013)
Article DOI: 10.1016/j.bmcl.2012.11.077
BindingDB Entry DOI: 10.7270/Q2C82BMR |
More data for this
Ligand-Target Pair | |
cGMP-dependent 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50425136
(CHEMBL2313254)Show InChI InChI=1S/C19H18N6O/c1-4-20-19(26)13-7-8-15-16(10-13)25-17(12(3)22-15)23-24-18(25)14-6-5-9-21-11(14)2/h5-10H,4H2,1-3H3,(H,20,26) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 6.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen-Cilag S.A.
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PDE2A expressed in Sf9 cells by scintillation proximity assay |
Bioorg Med Chem Lett 23: 785-90 (2013)
Article DOI: 10.1016/j.bmcl.2012.11.077
BindingDB Entry DOI: 10.7270/Q2C82BMR |
More data for this
Ligand-Target Pair | |
cGMP-dependent 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50425121
(CHEMBL2313236)Show SMILES CN1CCN(Cc2ccc3nc(C)c4nnc(-c5ccccc5Cl)n4c3c2)CC1 Show InChI InChI=1S/C22H23ClN6/c1-15-21-25-26-22(17-5-3-4-6-18(17)23)29(21)20-13-16(7-8-19(20)24-15)14-28-11-9-27(2)10-12-28/h3-8,13H,9-12,14H2,1-2H3 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 7.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen-Cilag S.A.
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PDE2A expressed in Sf9 cells by scintillation proximity assay |
Bioorg Med Chem Lett 23: 785-90 (2013)
Article DOI: 10.1016/j.bmcl.2012.11.077
BindingDB Entry DOI: 10.7270/Q2C82BMR |
More data for this
Ligand-Target Pair | |
cGMP-dependent 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50425120
(CHEMBL2313237)Show SMILES Cc1nc2ccc(NC3CCOCC3)cc2n2c(nnc12)-c1ccccc1Cl Show InChI InChI=1S/C21H20ClN5O/c1-13-20-25-26-21(16-4-2-3-5-17(16)22)27(20)19-12-15(6-7-18(19)23-13)24-14-8-10-28-11-9-14/h2-7,12,14,24H,8-11H2,1H3 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 7.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen-Cilag S.A.
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PDE2A expressed in Sf9 cells by scintillation proximity assay |
Bioorg Med Chem Lett 23: 785-90 (2013)
Article DOI: 10.1016/j.bmcl.2012.11.077
BindingDB Entry DOI: 10.7270/Q2C82BMR |
More data for this
Ligand-Target Pair | |
cGMP-dependent 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50425133
(CHEMBL2313257)Show SMILES CCNC(=O)c1ccc2nc(C)c3nnc(-c4cncc(OC)c4)n3c2c1 Show InChI InChI=1S/C19H18N6O2/c1-4-21-19(26)12-5-6-15-16(8-12)25-17(11(2)22-15)23-24-18(25)13-7-14(27-3)10-20-9-13/h5-10H,4H2,1-3H3,(H,21,26) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 8.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen-Cilag S.A.
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PDE2A expressed in Sf9 cells by scintillation proximity assay |
Bioorg Med Chem Lett 23: 785-90 (2013)
Article DOI: 10.1016/j.bmcl.2012.11.077
BindingDB Entry DOI: 10.7270/Q2C82BMR |
More data for this
Ligand-Target Pair | |
cGMP-dependent 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50425117
(CHEMBL2313240)Show SMILES Cc1nc2ccc(CN3CCC(O)CC3)cc2n2c(nnc12)-c1ccccc1Cl Show InChI InChI=1S/C22H22ClN5O/c1-14-21-25-26-22(17-4-2-3-5-18(17)23)28(21)20-12-15(6-7-19(20)24-14)13-27-10-8-16(29)9-11-27/h2-7,12,16,29H,8-11,13H2,1H3 | PDB
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| n/a | n/a | 9.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen-Cilag S.A.
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PDE2A expressed in Sf9 cells by scintillation proximity assay |
Bioorg Med Chem Lett 23: 785-90 (2013)
Article DOI: 10.1016/j.bmcl.2012.11.077
BindingDB Entry DOI: 10.7270/Q2C82BMR |
More data for this
Ligand-Target Pair | |
cGMP-dependent 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50425119
(CHEMBL2313238)Show SMILES Cc1nc2ccc(N[C@H]3CC[C@H](O)CC3)cc2n2c(nnc12)-c1ccccc1Cl |r,wU:11.11,wD:8.7,(29.29,-13.91,;30.62,-14.67,;30.63,-16.21,;31.96,-16.96,;31.96,-18.51,;33.29,-19.28,;34.63,-18.51,;35.96,-19.28,;37.29,-18.5,;38.62,-19.28,;39.95,-18.51,;39.95,-16.97,;41.29,-16.21,;38.62,-16.2,;37.28,-16.97,;34.62,-16.96,;33.29,-16.19,;33.28,-14.67,;34.43,-13.63,;33.8,-12.23,;32.27,-12.39,;31.95,-13.9,;35.93,-13.95,;36.41,-15.41,;37.91,-15.73,;38.94,-14.59,;38.46,-13.12,;36.95,-12.81,;36.47,-11.34,)| Show InChI InChI=1S/C22H22ClN5O/c1-13-21-26-27-22(17-4-2-3-5-18(17)23)28(21)20-12-15(8-11-19(20)24-13)25-14-6-9-16(29)10-7-14/h2-5,8,11-12,14,16,25,29H,6-7,9-10H2,1H3/t14-,16- | PDB
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| n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen-Cilag S.A.
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PDE2A expressed in Sf9 cells by scintillation proximity assay |
Bioorg Med Chem Lett 23: 785-90 (2013)
Article DOI: 10.1016/j.bmcl.2012.11.077
BindingDB Entry DOI: 10.7270/Q2C82BMR |
More data for this
Ligand-Target Pair | |
cGMP-dependent 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50425116
(CHEMBL2313241)Show SMILES COC1CCN(Cc2ccc3nc(C)c4nnc(-c5ccccc5Cl)n4c3c2)CC1 Show InChI InChI=1S/C23H24ClN5O/c1-15-22-26-27-23(18-5-3-4-6-19(18)24)29(22)21-13-16(7-8-20(21)25-15)14-28-11-9-17(30-2)10-12-28/h3-8,13,17H,9-12,14H2,1-2H3 | PDB
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| n/a | n/a | 15 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen-Cilag S.A.
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PDE2A expressed in Sf9 cells by scintillation proximity assay |
Bioorg Med Chem Lett 23: 785-90 (2013)
Article DOI: 10.1016/j.bmcl.2012.11.077
BindingDB Entry DOI: 10.7270/Q2C82BMR |
More data for this
Ligand-Target Pair | |
cGMP-dependent 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50425122
(CHEMBL2313235)Show SMILES Cc1nc2ccc(CNCc3ccccc3)cc2n2c(nnc12)-c1ccccc1Cl Show InChI InChI=1S/C24H20ClN5/c1-16-23-28-29-24(19-9-5-6-10-20(19)25)30(23)22-13-18(11-12-21(22)27-16)15-26-14-17-7-3-2-4-8-17/h2-13,26H,14-15H2,1H3 | PDB
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| n/a | n/a | 15 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen-Cilag S.A.
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PDE2A expressed in Sf9 cells by scintillation proximity assay |
Bioorg Med Chem Lett 23: 785-90 (2013)
Article DOI: 10.1016/j.bmcl.2012.11.077
BindingDB Entry DOI: 10.7270/Q2C82BMR |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Rattus norvegicus (rat)) | BDBM50425129
(CHEMBL2313261)Show SMILES CCN(CC)CCNC(=O)c1ccc2nc(C)c3nnc(-c4ccccc4Cl)n3c2c1 Show InChI InChI=1S/C23H25ClN6O/c1-4-29(5-2)13-12-25-23(31)16-10-11-19-20(14-16)30-21(15(3)26-19)27-28-22(30)17-8-6-7-9-18(17)24/h6-11,14H,4-5,12-13H2,1-3H3,(H,25,31) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
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| n/a | n/a | 19 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen-Cilag S.A.
Curated by ChEMBL
| Assay Description
Inhibition of rat PDE10A expressed in Sf9 cells by scintillation proximity assay |
Bioorg Med Chem Lett 23: 785-90 (2013)
Article DOI: 10.1016/j.bmcl.2012.11.077
BindingDB Entry DOI: 10.7270/Q2C82BMR |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Rattus norvegicus (rat)) | BDBM50425140
(CHEMBL2313250)Show SMILES CCNC(=O)c1ccc2nc(C)c3nnc(-c4c(Cl)cccc4Cl)n3c2c1 |(41.13,-18.18,;39.8,-18.95,;38.47,-18.18,;37.13,-18.95,;37.14,-20.49,;35.8,-18.19,;34.46,-18.96,;33.13,-18.19,;33.13,-16.64,;31.79,-15.89,;31.79,-14.35,;30.45,-13.58,;33.12,-13.58,;33.44,-12.07,;34.97,-11.9,;35.6,-13.31,;37.1,-13.63,;38.12,-12.48,;37.64,-11.02,;39.63,-12.79,;40.11,-14.26,;39.08,-15.41,;37.58,-15.09,;36.55,-16.24,;34.45,-14.34,;34.46,-15.87,;35.79,-16.64,)| Show InChI InChI=1S/C19H15Cl2N5O/c1-3-22-19(27)11-7-8-14-15(9-11)26-17(10(2)23-14)24-25-18(26)16-12(20)5-4-6-13(16)21/h4-9H,3H2,1-2H3,(H,22,27) | PDB
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| n/a | n/a | 19 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen-Cilag S.A.
Curated by ChEMBL
| Assay Description
Inhibition of rat PDE10A expressed in Sf9 cells by scintillation proximity assay |
Bioorg Med Chem Lett 23: 785-90 (2013)
Article DOI: 10.1016/j.bmcl.2012.11.077
BindingDB Entry DOI: 10.7270/Q2C82BMR |
More data for this
Ligand-Target Pair | |
cGMP-dependent 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50425131
(CHEMBL2313259)Show SMILES CN(Cc1ccccc1)C(=O)c1ccc2nc(C)c3nnc(-c4ccccc4Cl)n3c2c1 Show InChI InChI=1S/C25H20ClN5O/c1-16-23-28-29-24(19-10-6-7-11-20(19)26)31(23)22-14-18(12-13-21(22)27-16)25(32)30(2)15-17-8-4-3-5-9-17/h3-14H,15H2,1-2H3 | PDB
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| n/a | n/a | 19 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen-Cilag S.A.
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PDE2A expressed in Sf9 cells by scintillation proximity assay |
Bioorg Med Chem Lett 23: 785-90 (2013)
Article DOI: 10.1016/j.bmcl.2012.11.077
BindingDB Entry DOI: 10.7270/Q2C82BMR |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Rattus norvegicus (rat)) | BDBM50425118
(CHEMBL2313239)Show SMILES Cc1nc2ccc(CN3CCC(O)C3)cc2n2c(nnc12)-c1ccccc1Cl Show InChI InChI=1S/C21H20ClN5O/c1-13-20-24-25-21(16-4-2-3-5-17(16)22)27(20)19-10-14(6-7-18(19)23-13)11-26-9-8-15(28)12-26/h2-7,10,15,28H,8-9,11-12H2,1H3 | PDB
MMDB
Reactome pathway
KEGG
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| n/a | n/a | 19 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen-Cilag S.A.
Curated by ChEMBL
| Assay Description
Inhibition of rat PDE10A expressed in Sf9 cells by scintillation proximity assay |
Bioorg Med Chem Lett 23: 785-90 (2013)
Article DOI: 10.1016/j.bmcl.2012.11.077
BindingDB Entry DOI: 10.7270/Q2C82BMR |
More data for this
Ligand-Target Pair | |
cGMP-dependent 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50425124
(CHEMBL2313233 | US9669035, B-13)Show InChI InChI=1S/C19H18ClN5/c1-12-18-22-23-19(14-6-4-5-7-15(14)20)25(18)17-10-13(11-24(2)3)8-9-16(17)21-12/h4-10H,11H2,1-3H3 | PDB
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| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen-Cilag S.A.
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PDE2A expressed in Sf9 cells by scintillation proximity assay |
Bioorg Med Chem Lett 23: 785-90 (2013)
Article DOI: 10.1016/j.bmcl.2012.11.077
BindingDB Entry DOI: 10.7270/Q2C82BMR |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM50425139
(CHEMBL2313251)Show InChI InChI=1S/C18H16N6O/c1-3-19-18(25)12-7-8-13-15(10-12)24-16(11(2)21-13)22-23-17(24)14-6-4-5-9-20-14/h4-10H,3H2,1-2H3,(H,19,25) | PDB
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| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen-Cilag S.A.
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PDE10A expressed in Sf9 cells by scintillation proximity assay |
Bioorg Med Chem Lett 23: 785-90 (2013)
Article DOI: 10.1016/j.bmcl.2012.11.077
BindingDB Entry DOI: 10.7270/Q2C82BMR |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM50425128
(CHEMBL2313262)Show SMILES Cc1nc2ccc(cc2n2c(nnc12)-c1ccccc1Cl)C(=O)NCCN1CCCC1 Show InChI InChI=1S/C23H23ClN6O/c1-15-21-27-28-22(17-6-2-3-7-18(17)24)30(21)20-14-16(8-9-19(20)26-15)23(31)25-10-13-29-11-4-5-12-29/h2-3,6-9,14H,4-5,10-13H2,1H3,(H,25,31) | PDB
MMDB
Reactome pathway
KEGG
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| CHEMBL
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| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen-Cilag S.A.
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PDE10A expressed in Sf9 cells by scintillation proximity assay |
Bioorg Med Chem Lett 23: 785-90 (2013)
Article DOI: 10.1016/j.bmcl.2012.11.077
BindingDB Entry DOI: 10.7270/Q2C82BMR |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM50425117
(CHEMBL2313240)Show SMILES Cc1nc2ccc(CN3CCC(O)CC3)cc2n2c(nnc12)-c1ccccc1Cl Show InChI InChI=1S/C22H22ClN5O/c1-14-21-25-26-22(17-4-2-3-5-18(17)23)28(21)20-12-15(6-7-19(20)24-14)13-27-10-8-16(29)9-11-27/h2-7,12,16,29H,8-11,13H2,1H3 | PDB
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Reactome pathway
KEGG
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| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen-Cilag S.A.
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PDE10A expressed in Sf9 cells by scintillation proximity assay |
Bioorg Med Chem Lett 23: 785-90 (2013)
Article DOI: 10.1016/j.bmcl.2012.11.077
BindingDB Entry DOI: 10.7270/Q2C82BMR |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Rattus norvegicus (rat)) | BDBM50425115
(CHEMBL2313242)Show SMILES Cc1nc2ccc(CN3CCCC(O)C3)cc2n2c(nnc12)-c1ccccc1Cl Show InChI InChI=1S/C22H22ClN5O/c1-14-21-25-26-22(17-6-2-3-7-18(17)23)28(21)20-11-15(8-9-19(20)24-14)12-27-10-4-5-16(29)13-27/h2-3,6-9,11,16,29H,4-5,10,12-13H2,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
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| CHEMBL
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UniChem
Similars
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PubMed
| n/a | n/a | 21 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen-Cilag S.A.
Curated by ChEMBL
| Assay Description
Inhibition of rat PDE10A expressed in Sf9 cells by scintillation proximity assay |
Bioorg Med Chem Lett 23: 785-90 (2013)
Article DOI: 10.1016/j.bmcl.2012.11.077
BindingDB Entry DOI: 10.7270/Q2C82BMR |
More data for this
Ligand-Target Pair | |
cGMP-dependent 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50425135
(CHEMBL2313255)Show InChI InChI=1S/C19H18N6O/c1-4-21-19(26)13-5-6-15-16(9-13)25-17(12(3)22-15)23-24-18(25)14-10-20-8-7-11(14)2/h5-10H,4H2,1-3H3,(H,21,26) | PDB
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| n/a | n/a | 21 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen-Cilag S.A.
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PDE2A expressed in Sf9 cells by scintillation proximity assay |
Bioorg Med Chem Lett 23: 785-90 (2013)
Article DOI: 10.1016/j.bmcl.2012.11.077
BindingDB Entry DOI: 10.7270/Q2C82BMR |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Rattus norvegicus (rat)) | BDBM50425137
(CHEMBL2313253)Show InChI InChI=1S/C18H16N6O/c1-3-20-18(25)13-4-5-14-15(10-13)24-16(11(2)21-14)22-23-17(24)12-6-8-19-9-7-12/h4-10H,3H2,1-2H3,(H,20,25) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
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UniChem
Similars
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| n/a | n/a | 21 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen-Cilag S.A.
Curated by ChEMBL
| Assay Description
Inhibition of rat PDE10A expressed in Sf9 cells by scintillation proximity assay |
Bioorg Med Chem Lett 23: 785-90 (2013)
Article DOI: 10.1016/j.bmcl.2012.11.077
BindingDB Entry DOI: 10.7270/Q2C82BMR |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Rattus norvegicus (rat)) | BDBM50425126
(CHEMBL2313231)Show SMILES Cc1nc2ccc(cc2n2c(nnc12)-c1ccccc1Cl)C(=O)NCc1ccccn1 Show InChI InChI=1S/C23H17ClN6O/c1-14-21-28-29-22(17-7-2-3-8-18(17)24)30(21)20-12-15(9-10-19(20)27-14)23(31)26-13-16-6-4-5-11-25-16/h2-12H,13H2,1H3,(H,26,31) | PDB
MMDB
Reactome pathway
KEGG
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GoogleScholar
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| n/a | n/a | 21 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen-Cilag S.A.
Curated by ChEMBL
| Assay Description
Inhibition of rat PDE10A expressed in Sf9 cells by scintillation proximity assay |
Bioorg Med Chem Lett 23: 785-90 (2013)
Article DOI: 10.1016/j.bmcl.2012.11.077
BindingDB Entry DOI: 10.7270/Q2C82BMR |
More data for this
Ligand-Target Pair | |
cGMP-dependent 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50425125
(CHEMBL2313232 | US9669035, B-4)Show InChI InChI=1S/C19H18ClN5/c1-3-21-11-13-8-9-16-17(10-13)25-18(12(2)22-16)23-24-19(25)14-6-4-5-7-15(14)20/h4-10,21H,3,11H2,1-2H3 | PDB
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| n/a | n/a | 24 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen-Cilag S.A.
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PDE2A expressed in Sf9 cells by scintillation proximity assay |
Bioorg Med Chem Lett 23: 785-90 (2013)
Article DOI: 10.1016/j.bmcl.2012.11.077
BindingDB Entry DOI: 10.7270/Q2C82BMR |
More data for this
Ligand-Target Pair | |
cGMP-dependent 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50425114
(CHEMBL2313243)Show SMILES Cc1nc2ccc(CN3CCCC(CO)C3)cc2n2c(nnc12)-c1ccccc1Cl Show InChI InChI=1S/C23H24ClN5O/c1-15-22-26-27-23(18-6-2-3-7-19(18)24)29(22)21-11-16(8-9-20(21)25-15)12-28-10-4-5-17(13-28)14-30/h2-3,6-9,11,17,30H,4-5,10,12-14H2,1H3 | PDB
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| n/a | n/a | 24 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen-Cilag S.A.
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PDE2A expressed in Sf9 cells by scintillation proximity assay |
Bioorg Med Chem Lett 23: 785-90 (2013)
Article DOI: 10.1016/j.bmcl.2012.11.077
BindingDB Entry DOI: 10.7270/Q2C82BMR |
More data for this
Ligand-Target Pair | |
cGMP-dependent 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50425134
(CHEMBL2313256)Show SMILES CCNC(=O)c1ccc2nc(C)c3nnc(-c4cccnc4OC)n3c2c1 Show InChI InChI=1S/C19H18N6O2/c1-4-20-18(26)12-7-8-14-15(10-12)25-16(11(2)22-14)23-24-17(25)13-6-5-9-21-19(13)27-3/h5-10H,4H2,1-3H3,(H,20,26) | PDB
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| Article
PubMed
| n/a | n/a | 28 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen-Cilag S.A.
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PDE2A expressed in Sf9 cells by scintillation proximity assay |
Bioorg Med Chem Lett 23: 785-90 (2013)
Article DOI: 10.1016/j.bmcl.2012.11.077
BindingDB Entry DOI: 10.7270/Q2C82BMR |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM50425143
(CHEMBL2313247 | US11419874, Example 11)Show SMILES CCNC(=O)c1ccc2nc(C)c3nnc(-c4ccccc4Cl)n3c2c1 Show InChI InChI=1S/C19H16ClN5O/c1-3-21-19(26)12-8-9-15-16(10-12)25-17(11(2)22-15)23-24-18(25)13-6-4-5-7-14(13)20/h4-10H,3H2,1-2H3,(H,21,26) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 29 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen-Cilag S.A.
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PDE10A expressed in Sf9 cells by scintillation proximity assay |
Bioorg Med Chem Lett 23: 785-90 (2013)
Article DOI: 10.1016/j.bmcl.2012.11.077
BindingDB Entry DOI: 10.7270/Q2C82BMR |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM50425132
(CHEMBL2313258)Show SMILES Cc1nc2ccc(cc2n2c(nnc12)-c1ccccc1Cl)C(=O)NCc1ccccc1 Show InChI InChI=1S/C24H18ClN5O/c1-15-22-28-29-23(18-9-5-6-10-19(18)25)30(22)21-13-17(11-12-20(21)27-15)24(31)26-14-16-7-3-2-4-8-16/h2-13H,14H2,1H3,(H,26,31) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 29 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen-Cilag S.A.
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PDE10A expressed in Sf9 cells by scintillation proximity assay |
Bioorg Med Chem Lett 23: 785-90 (2013)
Article DOI: 10.1016/j.bmcl.2012.11.077
BindingDB Entry DOI: 10.7270/Q2C82BMR |
More data for this
Ligand-Target Pair | |
cGMP-dependent 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50425137
(CHEMBL2313253)Show InChI InChI=1S/C18H16N6O/c1-3-20-18(25)13-4-5-14-15(10-13)24-16(11(2)21-14)22-23-17(24)12-6-8-19-9-7-12/h4-10H,3H2,1-2H3,(H,20,25) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 29 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen-Cilag S.A.
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PDE2A expressed in Sf9 cells by scintillation proximity assay |
Bioorg Med Chem Lett 23: 785-90 (2013)
Article DOI: 10.1016/j.bmcl.2012.11.077
BindingDB Entry DOI: 10.7270/Q2C82BMR |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM50425121
(CHEMBL2313236)Show SMILES CN1CCN(Cc2ccc3nc(C)c4nnc(-c5ccccc5Cl)n4c3c2)CC1 Show InChI InChI=1S/C22H23ClN6/c1-15-21-25-26-22(17-5-3-4-6-18(17)23)29(21)20-13-16(7-8-19(20)24-15)14-28-11-9-27(2)10-12-28/h3-8,13H,9-12,14H2,1-2H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 29 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen-Cilag S.A.
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PDE10A expressed in Sf9 cells by scintillation proximity assay |
Bioorg Med Chem Lett 23: 785-90 (2013)
Article DOI: 10.1016/j.bmcl.2012.11.077
BindingDB Entry DOI: 10.7270/Q2C82BMR |
More data for this
Ligand-Target Pair | |
cGMP-dependent 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50425146
(CHEMBL2313245)Show InChI InChI=1S/C19H16N4O2/c1-3-25-19(24)14-9-10-15-16(11-14)23-17(12(2)20-15)21-22-18(23)13-7-5-4-6-8-13/h4-11H,3H2,1-2H3 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen-Cilag S.A.
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PDE2A expressed in Sf9 cells by scintillation proximity assay |
Bioorg Med Chem Lett 23: 785-90 (2013)
Article DOI: 10.1016/j.bmcl.2012.11.077
BindingDB Entry DOI: 10.7270/Q2C82BMR |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM50425145
(CHEMBL2311556)Show SMILES CCOC(=O)c1ccc2nc(C)c3nnc(-c4ccccc4Cl)n3c2c1 Show InChI InChI=1S/C19H15ClN4O2/c1-3-26-19(25)12-8-9-15-16(10-12)24-17(11(2)21-15)22-23-18(24)13-6-4-5-7-14(13)20/h4-10H,3H2,1-2H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 33 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen-Cilag S.A.
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PDE10A expressed in Sf9 cells by scintillation proximity assay |
Bioorg Med Chem Lett 23: 785-90 (2013)
Article DOI: 10.1016/j.bmcl.2012.11.077
BindingDB Entry DOI: 10.7270/Q2C82BMR |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM50425131
(CHEMBL2313259)Show SMILES CN(Cc1ccccc1)C(=O)c1ccc2nc(C)c3nnc(-c4ccccc4Cl)n3c2c1 Show InChI InChI=1S/C25H20ClN5O/c1-16-23-28-29-24(19-10-6-7-11-20(19)26)31(23)22-14-18(12-13-21(22)27-16)25(32)30(2)15-17-8-4-3-5-9-17/h3-14H,15H2,1-2H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 33 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen-Cilag S.A.
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PDE10A expressed in Sf9 cells by scintillation proximity assay |
Bioorg Med Chem Lett 23: 785-90 (2013)
Article DOI: 10.1016/j.bmcl.2012.11.077
BindingDB Entry DOI: 10.7270/Q2C82BMR |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM50425123
(CHEMBL2313234 | US9669035, B-3)Show SMILES Cc1nc2ccc(CN3CCOCC3)cc2n2c(nnc12)-c1ccccc1Cl Show InChI InChI=1S/C21H20ClN5O/c1-14-20-24-25-21(16-4-2-3-5-17(16)22)27(20)19-12-15(6-7-18(19)23-14)13-26-8-10-28-11-9-26/h2-7,12H,8-11,13H2,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 33 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen-Cilag S.A.
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PDE10A expressed in Sf9 cells by scintillation proximity assay |
Bioorg Med Chem Lett 23: 785-90 (2013)
Article DOI: 10.1016/j.bmcl.2012.11.077
BindingDB Entry DOI: 10.7270/Q2C82BMR |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM50425142
(CHEMBL2313248)Show SMILES CCNC(=O)c1ccc2nc(C)c3nnc(-c4ccccc4OC)n3c2c1 Show InChI InChI=1S/C20H19N5O2/c1-4-21-20(26)13-9-10-15-16(11-13)25-18(12(2)22-15)23-24-19(25)14-7-5-6-8-17(14)27-3/h5-11H,4H2,1-3H3,(H,21,26) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 33 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen-Cilag S.A.
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PDE10A expressed in Sf9 cells by scintillation proximity assay |
Bioorg Med Chem Lett 23: 785-90 (2013)
Article DOI: 10.1016/j.bmcl.2012.11.077
BindingDB Entry DOI: 10.7270/Q2C82BMR |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM50425120
(CHEMBL2313237)Show SMILES Cc1nc2ccc(NC3CCOCC3)cc2n2c(nnc12)-c1ccccc1Cl Show InChI InChI=1S/C21H20ClN5O/c1-13-20-25-26-21(16-4-2-3-5-17(16)22)27(20)19-12-15(6-7-18(19)23-13)24-14-8-10-28-11-9-14/h2-7,12,14,24H,8-11H2,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 33 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen-Cilag S.A.
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PDE10A expressed in Sf9 cells by scintillation proximity assay |
Bioorg Med Chem Lett 23: 785-90 (2013)
Article DOI: 10.1016/j.bmcl.2012.11.077
BindingDB Entry DOI: 10.7270/Q2C82BMR |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM50425134
(CHEMBL2313256)Show SMILES CCNC(=O)c1ccc2nc(C)c3nnc(-c4cccnc4OC)n3c2c1 Show InChI InChI=1S/C19H18N6O2/c1-4-20-18(26)12-7-8-14-15(10-12)25-16(11(2)22-14)23-24-17(25)13-6-5-9-21-19(13)27-3/h5-10H,4H2,1-3H3,(H,20,26) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 33 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen-Cilag S.A.
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PDE10A expressed in Sf9 cells by scintillation proximity assay |
Bioorg Med Chem Lett 23: 785-90 (2013)
Article DOI: 10.1016/j.bmcl.2012.11.077
BindingDB Entry DOI: 10.7270/Q2C82BMR |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Rattus norvegicus (rat)) | BDBM50425134
(CHEMBL2313256)Show SMILES CCNC(=O)c1ccc2nc(C)c3nnc(-c4cccnc4OC)n3c2c1 Show InChI InChI=1S/C19H18N6O2/c1-4-20-18(26)12-7-8-14-15(10-12)25-16(11(2)22-14)23-24-17(25)13-6-5-9-21-19(13)27-3/h5-10H,4H2,1-3H3,(H,20,26) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 35 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen-Cilag S.A.
Curated by ChEMBL
| Assay Description
Inhibition of rat PDE10A expressed in Sf9 cells by scintillation proximity assay |
Bioorg Med Chem Lett 23: 785-90 (2013)
Article DOI: 10.1016/j.bmcl.2012.11.077
BindingDB Entry DOI: 10.7270/Q2C82BMR |
More data for this
Ligand-Target Pair | |
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