Compile Data Set for Download or QSAR

Found 50 hits Enz. Inhib. hit(s) with all data for entry = 50009582   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Neuronal acetylcholine receptor subunit alpha-7 (Rattus norvegicus (Rat))	BDBM50530219 (CHEMBL4454983) Show SMILES [H][C@]12C[C@]3([H])[C@]([H])([C@H]1OC)[C@](O)(C[C@@H]2OC)[C@@]1(O)[C@@H](OC)[C@@]2([H])[C@@]33[C@H](CC[C@@]2(COC(=O)c2ccccc2N2C(=O)C[C@H](C)C2=O)CN(CC)[C@]13[H])OC |r,TLB:2:3:50:21.18,27:21:50:10.5.3,28:27:23:16.18,10:16:46.47.27:23,THB:8:7:3.2:10.13.12,52:24:50.46.47:21,19:18:50:10.5.3,19:18:46.47.27:23,47:50:21.18:10.5.3,11:10:50:21.18,26:27:23:16.18,24:23:46.47.27:16.18,48:47:23:16.18| Show InChI InChI=1S/C37H50N2O10/c1-7-38-17-34(18-49-32(42)20-10-8-9-11-23(20)39-26(40)14-19(2)31(39)41)13-12-25(46-4)36-22-15-21-24(45-3)16-35(43,27(22)28(21)47-5)37(44,33(36)38)30(48-6)29(34)36/h8-11,19,21-22,24-25,27-30,33,43-44H,7,12-18H2,1-6H3/t19-,21+,22+,24-,25-,27+,28-,29+,30-,33-,34-,35+,36-,37+/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid PDB UniChem	Article PubMed	1.40	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Florence Curated by ChEMBL					Assay Description Displacement of [3H]-methyllycaconitine from alpha7* nAChR in rat brain P2 membranes after 2.5 hrs by liquid scintillation spectrometry				J Med Chem 62: 1887-1901 (2019) Article DOI: 10.1021/acs.jmedchem.8b01372 BindingDB Entry DOI: 10.7270/Q2PR80F8
					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7 (Rattus norvegicus (Rat))	BDBM50530219 (CHEMBL4454983) Show SMILES [H][C@]12C[C@]3([H])[C@]([H])([C@H]1OC)[C@](O)(C[C@@H]2OC)[C@@]1(O)[C@@H](OC)[C@@]2([H])[C@@]33[C@H](CC[C@@]2(COC(=O)c2ccccc2N2C(=O)C[C@H](C)C2=O)CN(CC)[C@]13[H])OC |r,TLB:2:3:50:21.18,27:21:50:10.5.3,28:27:23:16.18,10:16:46.47.27:23,THB:8:7:3.2:10.13.12,52:24:50.46.47:21,19:18:50:10.5.3,19:18:46.47.27:23,47:50:21.18:10.5.3,11:10:50:21.18,26:27:23:16.18,24:23:46.47.27:16.18,48:47:23:16.18| Show InChI InChI=1S/C37H50N2O10/c1-7-38-17-34(18-49-32(42)20-10-8-9-11-23(20)39-26(40)14-19(2)31(39)41)13-12-25(46-4)36-22-15-21-24(45-3)16-35(43,27(22)28(21)47-5)37(44,33(36)38)30(48-6)29(34)36/h8-11,19,21-22,24-25,27-30,33,43-44H,7,12-18H2,1-6H3/t19-,21+,22+,24-,25-,27+,28-,29+,30-,33-,34-,35+,36-,37+/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid PDB UniChem	Article PubMed	1.40	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Florence Curated by ChEMBL					Assay Description Displacement of [3H]-methyllycaconitine from alpha7* nAChR in rat brain P2 membranes after 2.5 hrs by liquid scintillation spectrometry				J Med Chem 62: 1887-1901 (2019) Article DOI: 10.1021/acs.jmedchem.8b01372 BindingDB Entry DOI: 10.7270/Q2PR80F8
					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7 (Rattus norvegicus (Rat))	BDBM50530216 (CHEMBL4582201) Show SMILES [H][C@@]12CC[C@@]([H])(C1)[C@H]([C@@H]2N)c1ccc(Cl)nc1 |r,TLB:9:8:2.3:6,THB:10:7:2.3:6| Show InChI InChI=1S/C12H15ClN2/c13-10-4-3-9(6-15-10)11-7-1-2-8(5-7)12(11)14/h3-4,6-8,11-12H,1-2,5,14H2/t7-,8+,11-,12+/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	11	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Florence Curated by ChEMBL					Assay Description Displacement of [3H]-methyllycaconitine from alpha7* nAChR in rat brain P2 membranes after 2.5 hrs by liquid scintillation spectrometry				J Med Chem 62: 1887-1901 (2019) Article DOI: 10.1021/acs.jmedchem.8b01372 BindingDB Entry DOI: 10.7270/Q2PR80F8
					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7 (Rattus norvegicus (Rat))	BDBM50530216 (CHEMBL4582201) Show SMILES [H][C@@]12CC[C@@]([H])(C1)[C@H]([C@@H]2N)c1ccc(Cl)nc1 |r,TLB:9:8:2.3:6,THB:10:7:2.3:6| Show InChI InChI=1S/C12H15ClN2/c13-10-4-3-9(6-15-10)11-7-1-2-8(5-7)12(11)14/h3-4,6-8,11-12H,1-2,5,14H2/t7-,8+,11-,12+/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	11	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Florence Curated by ChEMBL					Assay Description Displacement of [3H]-methyllycaconitine from alpha7* nAChR in rat brain P2 membranes after 2.5 hrs by liquid scintillation spectrometry				J Med Chem 62: 1887-1901 (2019) Article DOI: 10.1021/acs.jmedchem.8b01372 BindingDB Entry DOI: 10.7270/Q2PR80F8
					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7 (Rattus norvegicus (Rat))	BDBM50530217 (CHEMBL4550498) Show SMILES [H][C@@]12CC[C@@]([H])(C1)[C@H]([C@@H]2N)c1cccnc1 |r,TLB:9:8:2.3:6,THB:10:7:2.3:6| Show InChI InChI=1S/C12H16N2/c13-12-9-4-3-8(6-9)11(12)10-2-1-5-14-7-10/h1-2,5,7-9,11-12H,3-4,6,13H2/t8-,9+,11-,12+/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	46	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Florence Curated by ChEMBL					Assay Description Displacement of [3H]-methyllycaconitine from alpha7* nAChR in rat brain P2 membranes after 2.5 hrs by liquid scintillation spectrometry				J Med Chem 62: 1887-1901 (2019) Article DOI: 10.1021/acs.jmedchem.8b01372 BindingDB Entry DOI: 10.7270/Q2PR80F8
					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7 (Rattus norvegicus (Rat))	BDBM50530217 (CHEMBL4550498) Show SMILES [H][C@@]12CC[C@@]([H])(C1)[C@H]([C@@H]2N)c1cccnc1 |r,TLB:9:8:2.3:6,THB:10:7:2.3:6| Show InChI InChI=1S/C12H16N2/c13-12-9-4-3-8(6-9)11(12)10-2-1-5-14-7-10/h1-2,5,7-9,11-12H,3-4,6,13H2/t8-,9+,11-,12+/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	46	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Florence Curated by ChEMBL					Assay Description Displacement of [3H]-methyllycaconitine from alpha7* nAChR in rat brain P2 membranes after 2.5 hrs by liquid scintillation spectrometry				J Med Chem 62: 1887-1901 (2019) Article DOI: 10.1021/acs.jmedchem.8b01372 BindingDB Entry DOI: 10.7270/Q2PR80F8
					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7 (Rattus norvegicus (Rat))	BDBM50530222 (CHEMBL4440670) Show SMILES [H][C@@]12CC[C@@]([H])(C1)[C@H]([C@@H]2NC)c1ccc(Cl)nc1 |r,TLB:9:8:2.3:6,THB:11:7:2.3:6| Show InChI InChI=1S/C13H17ClN2/c1-15-13-9-3-2-8(6-9)12(13)10-4-5-11(14)16-7-10/h4-5,7-9,12-13,15H,2-3,6H2,1H3/t8-,9+,12-,13+/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	116	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Florence Curated by ChEMBL					Assay Description Displacement of [3H]-methyllycaconitine from alpha7* nAChR in rat brain P2 membranes after 2.5 hrs by liquid scintillation spectrometry				J Med Chem 62: 1887-1901 (2019) Article DOI: 10.1021/acs.jmedchem.8b01372 BindingDB Entry DOI: 10.7270/Q2PR80F8
					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7 (Rattus norvegicus (Rat))	BDBM50530222 (CHEMBL4440670) Show SMILES [H][C@@]12CC[C@@]([H])(C1)[C@H]([C@@H]2NC)c1ccc(Cl)nc1 |r,TLB:9:8:2.3:6,THB:11:7:2.3:6| Show InChI InChI=1S/C13H17ClN2/c1-15-13-9-3-2-8(6-9)12(13)10-4-5-11(14)16-7-10/h4-5,7-9,12-13,15H,2-3,6H2,1H3/t8-,9+,12-,13+/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	116	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Florence Curated by ChEMBL					Assay Description Displacement of [3H]-methyllycaconitine from alpha7* nAChR in rat brain P2 membranes after 2.5 hrs by liquid scintillation spectrometry				J Med Chem 62: 1887-1901 (2019) Article DOI: 10.1021/acs.jmedchem.8b01372 BindingDB Entry DOI: 10.7270/Q2PR80F8
					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7 (Rattus norvegicus (Rat))	BDBM50530224 (CHEMBL4552618) Show SMILES [H][C@]12CC[C@]([H])(C1)[C@H]([C@@H]2N)c1ccc(Cl)nc1 |r,TLB:10:7:3.2:6,THB:9:8:3.2:6| Show InChI InChI=1S/C12H15ClN2/c13-10-4-3-9(6-15-10)11-7-1-2-8(5-7)12(11)14/h3-4,6-8,11-12H,1-2,5,14H2/t7-,8+,11+,12-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	227	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Florence Curated by ChEMBL					Assay Description Displacement of [3H]-methyllycaconitine from alpha7* nAChR in rat brain P2 membranes after 2.5 hrs by liquid scintillation spectrometry				J Med Chem 62: 1887-1901 (2019) Article DOI: 10.1021/acs.jmedchem.8b01372 BindingDB Entry DOI: 10.7270/Q2PR80F8
					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7 (Rattus norvegicus (Rat))	BDBM50530224 (CHEMBL4552618) Show SMILES [H][C@]12CC[C@]([H])(C1)[C@H]([C@@H]2N)c1ccc(Cl)nc1 |r,TLB:10:7:3.2:6,THB:9:8:3.2:6| Show InChI InChI=1S/C12H15ClN2/c13-10-4-3-9(6-15-10)11-7-1-2-8(5-7)12(11)14/h3-4,6-8,11-12H,1-2,5,14H2/t7-,8+,11+,12-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	227	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Florence Curated by ChEMBL					Assay Description Displacement of [3H]-methyllycaconitine from alpha7* nAChR in rat brain P2 membranes after 2.5 hrs by liquid scintillation spectrometry				J Med Chem 62: 1887-1901 (2019) Article DOI: 10.1021/acs.jmedchem.8b01372 BindingDB Entry DOI: 10.7270/Q2PR80F8
					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7 (Rattus norvegicus (Rat))	BDBM50530215 (CHEMBL4475133) Show SMILES [H][C@@]12CC[C@@]([H])(C1)[C@H]([C@@H]2NC)c1cccnc1 |r,TLB:9:8:2.3:6,THB:11:7:2.3:6| Show InChI InChI=1S/C13H18N2/c1-14-13-10-5-4-9(7-10)12(13)11-3-2-6-15-8-11/h2-3,6,8-10,12-14H,4-5,7H2,1H3/t9-,10+,12-,13+/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	352	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Florence Curated by ChEMBL					Assay Description Displacement of [3H]-methyllycaconitine from alpha7* nAChR in rat brain P2 membranes after 2.5 hrs by liquid scintillation spectrometry				J Med Chem 62: 1887-1901 (2019) Article DOI: 10.1021/acs.jmedchem.8b01372 BindingDB Entry DOI: 10.7270/Q2PR80F8
					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7 (Rattus norvegicus (Rat))	BDBM50530215 (CHEMBL4475133) Show SMILES [H][C@@]12CC[C@@]([H])(C1)[C@H]([C@@H]2NC)c1cccnc1 |r,TLB:9:8:2.3:6,THB:11:7:2.3:6| Show InChI InChI=1S/C13H18N2/c1-14-13-10-5-4-9(7-10)12(13)11-3-2-6-15-8-11/h2-3,6,8-10,12-14H,4-5,7H2,1H3/t9-,10+,12-,13+/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	352	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Florence Curated by ChEMBL					Assay Description Displacement of [3H]-methyllycaconitine from alpha7* nAChR in rat brain P2 membranes after 2.5 hrs by liquid scintillation spectrometry				J Med Chem 62: 1887-1901 (2019) Article DOI: 10.1021/acs.jmedchem.8b01372 BindingDB Entry DOI: 10.7270/Q2PR80F8
					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7 (Rattus norvegicus (Rat))	BDBM50530218 (CHEMBL4515416) Show SMILES [H][C@@]12CC[C@@]([H])(C1)[C@H]([C@@H]2N(C)C)c1ccc(Cl)nc1 |r,TLB:9:8:2.3:6,THB:12:7:2.3:6| Show InChI InChI=1S/C14H19ClN2/c1-17(2)14-10-4-3-9(7-10)13(14)11-5-6-12(15)16-8-11/h5-6,8-10,13-14H,3-4,7H2,1-2H3/t9-,10+,13-,14+/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Florence Curated by ChEMBL					Assay Description Displacement of [3H]-methyllycaconitine from alpha7* nAChR in rat brain P2 membranes after 2.5 hrs by liquid scintillation spectrometry				J Med Chem 62: 1887-1901 (2019) Article DOI: 10.1021/acs.jmedchem.8b01372 BindingDB Entry DOI: 10.7270/Q2PR80F8
					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7 (Rattus norvegicus (Rat))	BDBM50530220 (CHEMBL4438099) Show SMILES [H][C@]12CC[C@]([H])(C1)[C@H]([C@@H]2N(C)C)c1ccc(Cl)nc1 |r,TLB:12:7:3.2:6,THB:9:8:3.2:6| Show InChI InChI=1S/C14H19ClN2/c1-17(2)14-10-4-3-9(7-10)13(14)11-5-6-12(15)16-8-11/h5-6,8-10,13-14H,3-4,7H2,1-2H3/t9-,10+,13+,14-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Florence Curated by ChEMBL					Assay Description Displacement of [3H]-methyllycaconitine from alpha7* nAChR in rat brain P2 membranes after 2.5 hrs by liquid scintillation spectrometry				J Med Chem 62: 1887-1901 (2019) Article DOI: 10.1021/acs.jmedchem.8b01372 BindingDB Entry DOI: 10.7270/Q2PR80F8
					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7 (Rattus norvegicus (Rat))	BDBM50530226 (CHEMBL4448467) Show SMILES [H][C@@]12CC[C@@]([H])(C1)[C@H]([C@@H]2N(C)C)c1cccnc1 |r,TLB:9:8:2.3:6,THB:12:7:2.3:6| Show InChI InChI=1S/C14H20N2/c1-16(2)14-11-6-5-10(8-11)13(14)12-4-3-7-15-9-12/h3-4,7,9-11,13-14H,5-6,8H2,1-2H3/t10-,11+,13-,14+/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Florence Curated by ChEMBL					Assay Description Displacement of [3H]-methyllycaconitine from alpha7* nAChR in rat brain P2 membranes after 2.5 hrs by liquid scintillation spectrometry				J Med Chem 62: 1887-1901 (2019) Article DOI: 10.1021/acs.jmedchem.8b01372 BindingDB Entry DOI: 10.7270/Q2PR80F8
					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7 (Rattus norvegicus (Rat))	BDBM50530221 (CHEMBL4522629) Show SMILES [H][C@]12CC[C@]([H])(C1)[C@H]([C@@H]2N(C)C)c1cccnc1 |r,TLB:12:7:3.2:6,THB:9:8:3.2:6| Show InChI InChI=1S/C14H20N2/c1-16(2)14-11-6-5-10(8-11)13(14)12-4-3-7-15-9-12/h3-4,7,9-11,13-14H,5-6,8H2,1-2H3/t10-,11+,13+,14-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Florence Curated by ChEMBL					Assay Description Displacement of [3H]-methyllycaconitine from alpha7* nAChR in rat brain P2 membranes after 2.5 hrs by liquid scintillation spectrometry				J Med Chem 62: 1887-1901 (2019) Article DOI: 10.1021/acs.jmedchem.8b01372 BindingDB Entry DOI: 10.7270/Q2PR80F8
					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7 (Rattus norvegicus (Rat))	BDBM50530225 (CHEMBL4574804) Show SMILES [H][C@]12CC[C@]([H])(C1)[C@H]([C@@H]2N)c1cccnc1 |r,TLB:10:7:3.2:6,THB:9:8:3.2:6| Show InChI InChI=1S/C12H16N2/c13-12-9-4-3-8(6-9)11(12)10-2-1-5-14-7-10/h1-2,5,7-9,11-12H,3-4,6,13H2/t8-,9+,11+,12-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Florence Curated by ChEMBL					Assay Description Displacement of [3H]-methyllycaconitine from alpha7* nAChR in rat brain P2 membranes after 2.5 hrs by liquid scintillation spectrometry				J Med Chem 62: 1887-1901 (2019) Article DOI: 10.1021/acs.jmedchem.8b01372 BindingDB Entry DOI: 10.7270/Q2PR80F8
					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7 (Rattus norvegicus (Rat))	BDBM50530223 (CHEMBL4547457) Show SMILES [H][C@]12CC[C@]([H])(C1)[C@H]([C@@H]2NC)c1cccnc1 |r,TLB:11:7:3.2:6,THB:9:8:3.2:6| Show InChI InChI=1S/C13H18N2/c1-14-13-10-5-4-9(7-10)12(13)11-3-2-6-15-8-11/h2-3,6,8-10,12-14H,4-5,7H2,1H3/t9-,10+,12+,13-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Florence Curated by ChEMBL					Assay Description Displacement of [3H]-methyllycaconitine from alpha7* nAChR in rat brain P2 membranes after 2.5 hrs by liquid scintillation spectrometry				J Med Chem 62: 1887-1901 (2019) Article DOI: 10.1021/acs.jmedchem.8b01372 BindingDB Entry DOI: 10.7270/Q2PR80F8
					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7 (Rattus norvegicus (Rat))	BDBM50530226 (CHEMBL4448467) Show SMILES [H][C@@]12CC[C@@]([H])(C1)[C@H]([C@@H]2N(C)C)c1cccnc1 |r,TLB:9:8:2.3:6,THB:12:7:2.3:6| Show InChI InChI=1S/C14H20N2/c1-16(2)14-11-6-5-10(8-11)13(14)12-4-3-7-15-9-12/h3-4,7,9-11,13-14H,5-6,8H2,1-2H3/t10-,11+,13-,14+/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Florence Curated by ChEMBL					Assay Description Displacement of [3H]-methyllycaconitine from alpha7* nAChR in rat brain P2 membranes after 2.5 hrs by liquid scintillation spectrometry				J Med Chem 62: 1887-1901 (2019) Article DOI: 10.1021/acs.jmedchem.8b01372 BindingDB Entry DOI: 10.7270/Q2PR80F8
					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7 (Rattus norvegicus (Rat))	BDBM50530218 (CHEMBL4515416) Show SMILES [H][C@@]12CC[C@@]([H])(C1)[C@H]([C@@H]2N(C)C)c1ccc(Cl)nc1 |r,TLB:9:8:2.3:6,THB:12:7:2.3:6| Show InChI InChI=1S/C14H19ClN2/c1-17(2)14-10-4-3-9(7-10)13(14)11-5-6-12(15)16-8-11/h5-6,8-10,13-14H,3-4,7H2,1-2H3/t9-,10+,13-,14+/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Florence Curated by ChEMBL					Assay Description Displacement of [3H]-methyllycaconitine from alpha7* nAChR in rat brain P2 membranes after 2.5 hrs by liquid scintillation spectrometry				J Med Chem 62: 1887-1901 (2019) Article DOI: 10.1021/acs.jmedchem.8b01372 BindingDB Entry DOI: 10.7270/Q2PR80F8
					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7 (Rattus norvegicus (Rat))	BDBM50530223 (CHEMBL4547457) Show SMILES [H][C@]12CC[C@]([H])(C1)[C@H]([C@@H]2NC)c1cccnc1 |r,TLB:11:7:3.2:6,THB:9:8:3.2:6| Show InChI InChI=1S/C13H18N2/c1-14-13-10-5-4-9(7-10)12(13)11-3-2-6-15-8-11/h2-3,6,8-10,12-14H,4-5,7H2,1H3/t9-,10+,12+,13-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Florence Curated by ChEMBL					Assay Description Displacement of [3H]-methyllycaconitine from alpha7* nAChR in rat brain P2 membranes after 2.5 hrs by liquid scintillation spectrometry				J Med Chem 62: 1887-1901 (2019) Article DOI: 10.1021/acs.jmedchem.8b01372 BindingDB Entry DOI: 10.7270/Q2PR80F8
					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7 (Rattus norvegicus (Rat))	BDBM50530221 (CHEMBL4522629) Show SMILES [H][C@]12CC[C@]([H])(C1)[C@H]([C@@H]2N(C)C)c1cccnc1 |r,TLB:12:7:3.2:6,THB:9:8:3.2:6| Show InChI InChI=1S/C14H20N2/c1-16(2)14-11-6-5-10(8-11)13(14)12-4-3-7-15-9-12/h3-4,7,9-11,13-14H,5-6,8H2,1-2H3/t10-,11+,13+,14-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Florence Curated by ChEMBL					Assay Description Displacement of [3H]-methyllycaconitine from alpha7* nAChR in rat brain P2 membranes after 2.5 hrs by liquid scintillation spectrometry				J Med Chem 62: 1887-1901 (2019) Article DOI: 10.1021/acs.jmedchem.8b01372 BindingDB Entry DOI: 10.7270/Q2PR80F8
					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7 (Rattus norvegicus (Rat))	BDBM50530220 (CHEMBL4438099) Show SMILES [H][C@]12CC[C@]([H])(C1)[C@H]([C@@H]2N(C)C)c1ccc(Cl)nc1 |r,TLB:12:7:3.2:6,THB:9:8:3.2:6| Show InChI InChI=1S/C14H19ClN2/c1-17(2)14-10-4-3-9(7-10)13(14)11-5-6-12(15)16-8-11/h5-6,8-10,13-14H,3-4,7H2,1-2H3/t9-,10+,13+,14-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Florence Curated by ChEMBL					Assay Description Displacement of [3H]-methyllycaconitine from alpha7* nAChR in rat brain P2 membranes after 2.5 hrs by liquid scintillation spectrometry				J Med Chem 62: 1887-1901 (2019) Article DOI: 10.1021/acs.jmedchem.8b01372 BindingDB Entry DOI: 10.7270/Q2PR80F8
					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7 (Rattus norvegicus (Rat))	BDBM50530225 (CHEMBL4574804) Show SMILES [H][C@]12CC[C@]([H])(C1)[C@H]([C@@H]2N)c1cccnc1 |r,TLB:10:7:3.2:6,THB:9:8:3.2:6| Show InChI InChI=1S/C12H16N2/c13-12-9-4-3-8(6-9)11(12)10-2-1-5-14-7-10/h1-2,5,7-9,11-12H,3-4,6,13H2/t8-,9+,11+,12-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Florence Curated by ChEMBL					Assay Description Displacement of [3H]-methyllycaconitine from alpha7* nAChR in rat brain P2 membranes after 2.5 hrs by liquid scintillation spectrometry				J Med Chem 62: 1887-1901 (2019) Article DOI: 10.1021/acs.jmedchem.8b01372 BindingDB Entry DOI: 10.7270/Q2PR80F8
					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-3/beta-2 (Homo sapiens (Human))	BDBM50530218 (CHEMBL4515416) Show SMILES [H][C@@]12CC[C@@]([H])(C1)[C@H]([C@@H]2N(C)C)c1ccc(Cl)nc1 |r,TLB:9:8:2.3:6,THB:12:7:2.3:6| Show InChI InChI=1S/C14H19ClN2/c1-17(2)14-10-4-3-9(7-10)13(14)11-5-6-12(15)16-8-11/h5-6,8-10,13-14H,3-4,7H2,1-2H3/t9-,10+,13-,14+/m0/s1	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	2.86E+3	n/a	n/a	n/a	n/a
University of Florence Curated by ChEMBL					Assay Description Agonist activity at human alpha3beta2 nAChR expressed in Xenopus laevis oocytes after 4 to 5 days at -60 mV holding potential by patch clamp assay				J Med Chem 62: 1887-1901 (2019) Article DOI: 10.1021/acs.jmedchem.8b01372 BindingDB Entry DOI: 10.7270/Q2PR80F8
					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7 (Homo sapiens (Human))	BDBM50530216 (CHEMBL4582201) Show SMILES [H][C@@]12CC[C@@]([H])(C1)[C@H]([C@@H]2N)c1ccc(Cl)nc1 |r,TLB:9:8:2.3:6,THB:10:7:2.3:6| Show InChI InChI=1S/C12H15ClN2/c13-10-4-3-9(6-15-10)11-7-1-2-8(5-7)12(11)14/h3-4,6-8,11-12H,1-2,5,14H2/t7-,8+,11-,12+/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	24	n/a	n/a	n/a	n/a
University of Florence Curated by ChEMBL					Assay Description Agonist activity at human alpha7 nAChR expressed in mouse Neuro2a cells co-expressing chaperone NACHO assessed as increase in intracellular Ca2+ leve...				J Med Chem 62: 1887-1901 (2019) Article DOI: 10.1021/acs.jmedchem.8b01372 BindingDB Entry DOI: 10.7270/Q2PR80F8
					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7 (Rattus norvegicus (Rat))	BDBM50530215 (CHEMBL4475133) Show SMILES [H][C@@]12CC[C@@]([H])(C1)[C@H]([C@@H]2NC)c1cccnc1 |r,TLB:9:8:2.3:6,THB:11:7:2.3:6| Show InChI InChI=1S/C13H18N2/c1-14-13-10-5-4-9(7-10)12(13)11-3-2-6-15-8-11/h2-3,6,8-10,12-14H,4-5,7H2,1H3/t9-,10+,12-,13+/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a
University of Florence Curated by ChEMBL					Assay Description Agonist activity at rat alpha7 nAChR expressed in Xenopus laevis oocytes after 4 to 5 days at -60 mV holding potential by patch clamp assay				J Med Chem 62: 1887-1901 (2019) Article DOI: 10.1021/acs.jmedchem.8b01372 BindingDB Entry DOI: 10.7270/Q2PR80F8
					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-3/beta-2 (Homo sapiens (Human))	BDBM50530215 (CHEMBL4475133) Show SMILES [H][C@@]12CC[C@@]([H])(C1)[C@H]([C@@H]2NC)c1cccnc1 |r,TLB:9:8:2.3:6,THB:11:7:2.3:6| Show InChI InChI=1S/C13H18N2/c1-14-13-10-5-4-9(7-10)12(13)11-3-2-6-15-8-11/h2-3,6,8-10,12-14H,4-5,7H2,1H3/t9-,10+,12-,13+/m0/s1	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	6.55E+4	n/a	n/a	n/a	n/a
University of Florence Curated by ChEMBL					Assay Description Agonist activity at human alpha3beta2 nAChR expressed in Xenopus laevis oocytes after 4 to 5 days at -60 mV holding potential by patch clamp assay				J Med Chem 62: 1887-1901 (2019) Article DOI: 10.1021/acs.jmedchem.8b01372 BindingDB Entry DOI: 10.7270/Q2PR80F8
					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7 (Homo sapiens (Human))	BDBM50530215 (CHEMBL4475133) Show SMILES [H][C@@]12CC[C@@]([H])(C1)[C@H]([C@@H]2NC)c1cccnc1 |r,TLB:9:8:2.3:6,THB:11:7:2.3:6| Show InChI InChI=1S/C13H18N2/c1-14-13-10-5-4-9(7-10)12(13)11-3-2-6-15-8-11/h2-3,6,8-10,12-14H,4-5,7H2,1H3/t9-,10+,12-,13+/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	2.29E+3	n/a	n/a	n/a	n/a
University of Florence Curated by ChEMBL					Assay Description Agonist activity at human alpha7 nAChR expressed in mouse Neuro2a cells co-expressing chaperone NACHO assessed as increase in intracellular Ca2+ leve...				J Med Chem 62: 1887-1901 (2019) Article DOI: 10.1021/acs.jmedchem.8b01372 BindingDB Entry DOI: 10.7270/Q2PR80F8
					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7 (Rattus norvegicus (Rat))	BDBM50530217 (CHEMBL4550498) Show SMILES [H][C@@]12CC[C@@]([H])(C1)[C@H]([C@@H]2N)c1cccnc1 |r,TLB:9:8:2.3:6,THB:10:7:2.3:6| Show InChI InChI=1S/C12H16N2/c13-12-9-4-3-8(6-9)11(12)10-2-1-5-14-7-10/h1-2,5,7-9,11-12H,3-4,6,13H2/t8-,9+,11-,12+/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	5.98E+3	n/a	n/a	n/a	n/a
University of Florence Curated by ChEMBL					Assay Description Agonist activity at rat alpha7 nAChR expressed in Xenopus laevis oocytes after 4 to 5 days at -60 mV holding potential by patch clamp assay				J Med Chem 62: 1887-1901 (2019) Article DOI: 10.1021/acs.jmedchem.8b01372 BindingDB Entry DOI: 10.7270/Q2PR80F8
					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-3/beta-2 (Homo sapiens (Human))	BDBM50530216 (CHEMBL4582201) Show SMILES [H][C@@]12CC[C@@]([H])(C1)[C@H]([C@@H]2N)c1ccc(Cl)nc1 |r,TLB:9:8:2.3:6,THB:10:7:2.3:6| Show InChI InChI=1S/C12H15ClN2/c13-10-4-3-9(6-15-10)11-7-1-2-8(5-7)12(11)14/h3-4,6-8,11-12H,1-2,5,14H2/t7-,8+,11-,12+/m0/s1	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	430	n/a	n/a	n/a	n/a
University of Florence Curated by ChEMBL					Assay Description Agonist activity at human alpha3beta2 nAChR expressed in Xenopus laevis oocytes after 4 to 5 days at -60 mV holding potential by patch clamp assay				J Med Chem 62: 1887-1901 (2019) Article DOI: 10.1021/acs.jmedchem.8b01372 BindingDB Entry DOI: 10.7270/Q2PR80F8
					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7 (Rattus norvegicus (Rat))	BDBM50530216 (CHEMBL4582201) Show SMILES [H][C@@]12CC[C@@]([H])(C1)[C@H]([C@@H]2N)c1ccc(Cl)nc1 |r,TLB:9:8:2.3:6,THB:10:7:2.3:6| Show InChI InChI=1S/C12H15ClN2/c13-10-4-3-9(6-15-10)11-7-1-2-8(5-7)12(11)14/h3-4,6-8,11-12H,1-2,5,14H2/t7-,8+,11-,12+/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	2.71E+3	n/a	n/a	n/a	n/a
University of Florence Curated by ChEMBL					Assay Description Agonist activity at rat alpha7 nAChR expressed in Xenopus laevis oocytes after 4 to 5 days at -60 mV holding potential by patch clamp assay				J Med Chem 62: 1887-1901 (2019) Article DOI: 10.1021/acs.jmedchem.8b01372 BindingDB Entry DOI: 10.7270/Q2PR80F8
					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7 (Rattus norvegicus (Rat))	BDBM50530215 (CHEMBL4475133) Show SMILES [H][C@@]12CC[C@@]([H])(C1)[C@H]([C@@H]2NC)c1cccnc1 |r,TLB:9:8:2.3:6,THB:11:7:2.3:6| Show InChI InChI=1S/C13H18N2/c1-14-13-10-5-4-9(7-10)12(13)11-3-2-6-15-8-11/h2-3,6,8-10,12-14H,4-5,7H2,1H3/t9-,10+,12-,13+/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a
University of Florence Curated by ChEMBL					Assay Description Agonist activity at rat alpha7 nAChR expressed in Xenopus laevis oocytes after 4 to 5 days at -60 mV holding potential by patch clamp assay				J Med Chem 62: 1887-1901 (2019) Article DOI: 10.1021/acs.jmedchem.8b01372 BindingDB Entry DOI: 10.7270/Q2PR80F8
					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7 (Rattus norvegicus (Rat))	BDBM50530217 (CHEMBL4550498) Show SMILES [H][C@@]12CC[C@@]([H])(C1)[C@H]([C@@H]2N)c1cccnc1 |r,TLB:9:8:2.3:6,THB:10:7:2.3:6| Show InChI InChI=1S/C12H16N2/c13-12-9-4-3-8(6-9)11(12)10-2-1-5-14-7-10/h1-2,5,7-9,11-12H,3-4,6,13H2/t8-,9+,11-,12+/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	5.98E+3	n/a	n/a	n/a	n/a
University of Florence Curated by ChEMBL					Assay Description Agonist activity at rat alpha7 nAChR expressed in Xenopus laevis oocytes after 4 to 5 days at -60 mV holding potential by patch clamp assay				J Med Chem 62: 1887-1901 (2019) Article DOI: 10.1021/acs.jmedchem.8b01372 BindingDB Entry DOI: 10.7270/Q2PR80F8
					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7 (Homo sapiens (Human))	BDBM50530215 (CHEMBL4475133) Show SMILES [H][C@@]12CC[C@@]([H])(C1)[C@H]([C@@H]2NC)c1cccnc1 |r,TLB:9:8:2.3:6,THB:11:7:2.3:6| Show InChI InChI=1S/C13H18N2/c1-14-13-10-5-4-9(7-10)12(13)11-3-2-6-15-8-11/h2-3,6,8-10,12-14H,4-5,7H2,1H3/t9-,10+,12-,13+/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	2.29E+3	n/a	n/a	n/a	n/a
University of Florence Curated by ChEMBL					Assay Description Agonist activity at human alpha7 nAChR expressed in mouse Neuro2a cells co-expressing chaperone NACHO assessed as increase in intracellular Ca2+ leve...				J Med Chem 62: 1887-1901 (2019) Article DOI: 10.1021/acs.jmedchem.8b01372 BindingDB Entry DOI: 10.7270/Q2PR80F8
					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7 (Homo sapiens (Human))	BDBM50530218 (CHEMBL4515416) Show SMILES [H][C@@]12CC[C@@]([H])(C1)[C@H]([C@@H]2N(C)C)c1ccc(Cl)nc1 |r,TLB:9:8:2.3:6,THB:12:7:2.3:6| Show InChI InChI=1S/C14H19ClN2/c1-17(2)14-10-4-3-9(7-10)13(14)11-5-6-12(15)16-8-11/h5-6,8-10,13-14H,3-4,7H2,1-2H3/t9-,10+,13-,14+/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	6.45E+3	n/a	n/a	n/a	n/a
University of Florence Curated by ChEMBL					Assay Description Agonist activity at human alpha7 nAChR expressed in mouse Neuro2a cells co-expressing chaperone NACHO assessed as increase in intracellular Ca2+ leve...				J Med Chem 62: 1887-1901 (2019) Article DOI: 10.1021/acs.jmedchem.8b01372 BindingDB Entry DOI: 10.7270/Q2PR80F8
					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7 (Homo sapiens (Human))	BDBM82070 (CAS_29790-52-1 | NICOTINE-L (BASE) | Nicotine-D sa...) Show SMILES CN1CCC[C@H]1c1cccnc1 |r| Show InChI InChI=1S/C10H14N2/c1-12-7-3-5-10(12)9-4-2-6-11-8-9/h2,4,6,8,10H,3,5,7H2,1H3/t10-/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase KEGG PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	4.71E+3	n/a	n/a	n/a	n/a
University of Florence Curated by ChEMBL					Assay Description Agonist activity at human alpha7 nAChR expressed in mouse Neuro2a cells co-expressing chaperone NACHO assessed as increase in intracellular Ca2+ leve...				J Med Chem 62: 1887-1901 (2019) Article DOI: 10.1021/acs.jmedchem.8b01372 BindingDB Entry DOI: 10.7270/Q2PR80F8
					More data for this Ligand-Target Pair				3D Structure (crystal)
Neuronal acetylcholine receptor subunit alpha-7 (Rattus norvegicus (Rat))	BDBM50530218 (CHEMBL4515416) Show SMILES [H][C@@]12CC[C@@]([H])(C1)[C@H]([C@@H]2N(C)C)c1ccc(Cl)nc1 |r,TLB:9:8:2.3:6,THB:12:7:2.3:6| Show InChI InChI=1S/C14H19ClN2/c1-17(2)14-10-4-3-9(7-10)13(14)11-5-6-12(15)16-8-11/h5-6,8-10,13-14H,3-4,7H2,1-2H3/t9-,10+,13-,14+/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a
University of Florence Curated by ChEMBL					Assay Description Agonist activity at rat alpha7 nAChR expressed in Xenopus laevis oocytes after 4 to 5 days at -60 mV holding potential by patch clamp assay				J Med Chem 62: 1887-1901 (2019) Article DOI: 10.1021/acs.jmedchem.8b01372 BindingDB Entry DOI: 10.7270/Q2PR80F8
					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-3/beta-2 (Homo sapiens (Human))	BDBM50530216 (CHEMBL4582201) Show SMILES [H][C@@]12CC[C@@]([H])(C1)[C@H]([C@@H]2N)c1ccc(Cl)nc1 |r,TLB:9:8:2.3:6,THB:10:7:2.3:6| Show InChI InChI=1S/C12H15ClN2/c13-10-4-3-9(6-15-10)11-7-1-2-8(5-7)12(11)14/h3-4,6-8,11-12H,1-2,5,14H2/t7-,8+,11-,12+/m0/s1	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	430	n/a	n/a	n/a	n/a
University of Florence Curated by ChEMBL					Assay Description Agonist activity at human alpha3beta2 nAChR expressed in Xenopus laevis oocytes after 4 to 5 days at -60 mV holding potential by patch clamp assay				J Med Chem 62: 1887-1901 (2019) Article DOI: 10.1021/acs.jmedchem.8b01372 BindingDB Entry DOI: 10.7270/Q2PR80F8
					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7 (Homo sapiens (Human))	BDBM50530217 (CHEMBL4550498) Show SMILES [H][C@@]12CC[C@@]([H])(C1)[C@H]([C@@H]2N)c1cccnc1 |r,TLB:9:8:2.3:6,THB:10:7:2.3:6| Show InChI InChI=1S/C12H16N2/c13-12-9-4-3-8(6-9)11(12)10-2-1-5-14-7-10/h1-2,5,7-9,11-12H,3-4,6,13H2/t8-,9+,11-,12+/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	48	n/a	n/a	n/a	n/a
University of Florence Curated by ChEMBL					Assay Description Agonist activity at human alpha7 nAChR expressed in mouse Neuro2a cells co-expressing chaperone NACHO assessed as increase in intracellular Ca2+ leve...				J Med Chem 62: 1887-1901 (2019) Article DOI: 10.1021/acs.jmedchem.8b01372 BindingDB Entry DOI: 10.7270/Q2PR80F8
					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7 (Homo sapiens (Human))	BDBM50530218 (CHEMBL4515416) Show SMILES [H][C@@]12CC[C@@]([H])(C1)[C@H]([C@@H]2N(C)C)c1ccc(Cl)nc1 |r,TLB:9:8:2.3:6,THB:12:7:2.3:6| Show InChI InChI=1S/C14H19ClN2/c1-17(2)14-10-4-3-9(7-10)13(14)11-5-6-12(15)16-8-11/h5-6,8-10,13-14H,3-4,7H2,1-2H3/t9-,10+,13-,14+/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	6.45E+3	n/a	n/a	n/a	n/a
University of Florence Curated by ChEMBL					Assay Description Agonist activity at human alpha7 nAChR expressed in mouse Neuro2a cells co-expressing chaperone NACHO assessed as increase in intracellular Ca2+ leve...				J Med Chem 62: 1887-1901 (2019) Article DOI: 10.1021/acs.jmedchem.8b01372 BindingDB Entry DOI: 10.7270/Q2PR80F8
					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7 (Homo sapiens (Human))	BDBM82070 (CAS_29790-52-1 | NICOTINE-L (BASE) | Nicotine-D sa...) Show SMILES CN1CCC[C@H]1c1cccnc1 |r| Show InChI InChI=1S/C10H14N2/c1-12-7-3-5-10(12)9-4-2-6-11-8-9/h2,4,6,8,10H,3,5,7H2,1H3/t10-/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase KEGG PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	4.71E+3	n/a	n/a	n/a	n/a
University of Florence Curated by ChEMBL					Assay Description Agonist activity at human alpha7 nAChR expressed in mouse Neuro2a cells co-expressing chaperone NACHO assessed as increase in intracellular Ca2+ leve...				J Med Chem 62: 1887-1901 (2019) Article DOI: 10.1021/acs.jmedchem.8b01372 BindingDB Entry DOI: 10.7270/Q2PR80F8
					More data for this Ligand-Target Pair				3D Structure (crystal)
Neuronal acetylcholine receptor subunit alpha-7 (Rattus norvegicus (Rat))	BDBM50530216 (CHEMBL4582201) Show SMILES [H][C@@]12CC[C@@]([H])(C1)[C@H]([C@@H]2N)c1ccc(Cl)nc1 |r,TLB:9:8:2.3:6,THB:10:7:2.3:6| Show InChI InChI=1S/C12H15ClN2/c13-10-4-3-9(6-15-10)11-7-1-2-8(5-7)12(11)14/h3-4,6-8,11-12H,1-2,5,14H2/t7-,8+,11-,12+/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	2.71E+3	n/a	n/a	n/a	n/a
University of Florence Curated by ChEMBL					Assay Description Agonist activity at rat alpha7 nAChR expressed in Xenopus laevis oocytes after 4 to 5 days at -60 mV holding potential by patch clamp assay				J Med Chem 62: 1887-1901 (2019) Article DOI: 10.1021/acs.jmedchem.8b01372 BindingDB Entry DOI: 10.7270/Q2PR80F8
					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7 (Rattus norvegicus (Rat))	BDBM50530218 (CHEMBL4515416) Show SMILES [H][C@@]12CC[C@@]([H])(C1)[C@H]([C@@H]2N(C)C)c1ccc(Cl)nc1 |r,TLB:9:8:2.3:6,THB:12:7:2.3:6| Show InChI InChI=1S/C14H19ClN2/c1-17(2)14-10-4-3-9(7-10)13(14)11-5-6-12(15)16-8-11/h5-6,8-10,13-14H,3-4,7H2,1-2H3/t9-,10+,13-,14+/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a
University of Florence Curated by ChEMBL					Assay Description Agonist activity at rat alpha7 nAChR expressed in Xenopus laevis oocytes after 4 to 5 days at -60 mV holding potential by patch clamp assay				J Med Chem 62: 1887-1901 (2019) Article DOI: 10.1021/acs.jmedchem.8b01372 BindingDB Entry DOI: 10.7270/Q2PR80F8
					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-3/beta-2 (Homo sapiens (Human))	BDBM50530217 (CHEMBL4550498) Show SMILES [H][C@@]12CC[C@@]([H])(C1)[C@H]([C@@H]2N)c1cccnc1 |r,TLB:9:8:2.3:6,THB:10:7:2.3:6| Show InChI InChI=1S/C12H16N2/c13-12-9-4-3-8(6-9)11(12)10-2-1-5-14-7-10/h1-2,5,7-9,11-12H,3-4,6,13H2/t8-,9+,11-,12+/m0/s1	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	6.32E+3	n/a	n/a	n/a	n/a
University of Florence Curated by ChEMBL					Assay Description Agonist activity at human alpha3beta2 nAChR expressed in Xenopus laevis oocytes after 4 to 5 days at -60 mV holding potential by patch clamp assay				J Med Chem 62: 1887-1901 (2019) Article DOI: 10.1021/acs.jmedchem.8b01372 BindingDB Entry DOI: 10.7270/Q2PR80F8
					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-3/beta-2 (Homo sapiens (Human))	BDBM50530218 (CHEMBL4515416) Show SMILES [H][C@@]12CC[C@@]([H])(C1)[C@H]([C@@H]2N(C)C)c1ccc(Cl)nc1 |r,TLB:9:8:2.3:6,THB:12:7:2.3:6| Show InChI InChI=1S/C14H19ClN2/c1-17(2)14-10-4-3-9(7-10)13(14)11-5-6-12(15)16-8-11/h5-6,8-10,13-14H,3-4,7H2,1-2H3/t9-,10+,13-,14+/m0/s1	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	2.86E+3	n/a	n/a	n/a	n/a
University of Florence Curated by ChEMBL					Assay Description Agonist activity at human alpha3beta2 nAChR expressed in Xenopus laevis oocytes after 4 to 5 days at -60 mV holding potential by patch clamp assay				J Med Chem 62: 1887-1901 (2019) Article DOI: 10.1021/acs.jmedchem.8b01372 BindingDB Entry DOI: 10.7270/Q2PR80F8
					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7 (Homo sapiens (Human))	BDBM50530217 (CHEMBL4550498) Show SMILES [H][C@@]12CC[C@@]([H])(C1)[C@H]([C@@H]2N)c1cccnc1 |r,TLB:9:8:2.3:6,THB:10:7:2.3:6| Show InChI InChI=1S/C12H16N2/c13-12-9-4-3-8(6-9)11(12)10-2-1-5-14-7-10/h1-2,5,7-9,11-12H,3-4,6,13H2/t8-,9+,11-,12+/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	48	n/a	n/a	n/a	n/a
University of Florence Curated by ChEMBL					Assay Description Agonist activity at human alpha7 nAChR expressed in mouse Neuro2a cells co-expressing chaperone NACHO assessed as increase in intracellular Ca2+ leve...				J Med Chem 62: 1887-1901 (2019) Article DOI: 10.1021/acs.jmedchem.8b01372 BindingDB Entry DOI: 10.7270/Q2PR80F8
					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-3/beta-2 (Homo sapiens (Human))	BDBM50530217 (CHEMBL4550498) Show SMILES [H][C@@]12CC[C@@]([H])(C1)[C@H]([C@@H]2N)c1cccnc1 |r,TLB:9:8:2.3:6,THB:10:7:2.3:6| Show InChI InChI=1S/C12H16N2/c13-12-9-4-3-8(6-9)11(12)10-2-1-5-14-7-10/h1-2,5,7-9,11-12H,3-4,6,13H2/t8-,9+,11-,12+/m0/s1	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	6.32E+3	n/a	n/a	n/a	n/a
University of Florence Curated by ChEMBL					Assay Description Agonist activity at human alpha3beta2 nAChR expressed in Xenopus laevis oocytes after 4 to 5 days at -60 mV holding potential by patch clamp assay				J Med Chem 62: 1887-1901 (2019) Article DOI: 10.1021/acs.jmedchem.8b01372 BindingDB Entry DOI: 10.7270/Q2PR80F8
					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-3/beta-2 (Homo sapiens (Human))	BDBM50530215 (CHEMBL4475133) Show SMILES [H][C@@]12CC[C@@]([H])(C1)[C@H]([C@@H]2NC)c1cccnc1 |r,TLB:9:8:2.3:6,THB:11:7:2.3:6| Show InChI InChI=1S/C13H18N2/c1-14-13-10-5-4-9(7-10)12(13)11-3-2-6-15-8-11/h2-3,6,8-10,12-14H,4-5,7H2,1H3/t9-,10+,12-,13+/m0/s1	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	6.55E+4	n/a	n/a	n/a	n/a
University of Florence Curated by ChEMBL					Assay Description Agonist activity at human alpha3beta2 nAChR expressed in Xenopus laevis oocytes after 4 to 5 days at -60 mV holding potential by patch clamp assay				J Med Chem 62: 1887-1901 (2019) Article DOI: 10.1021/acs.jmedchem.8b01372 BindingDB Entry DOI: 10.7270/Q2PR80F8
					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7 (Homo sapiens (Human))	BDBM50530216 (CHEMBL4582201) Show SMILES [H][C@@]12CC[C@@]([H])(C1)[C@H]([C@@H]2N)c1ccc(Cl)nc1 |r,TLB:9:8:2.3:6,THB:10:7:2.3:6| Show InChI InChI=1S/C12H15ClN2/c13-10-4-3-9(6-15-10)11-7-1-2-8(5-7)12(11)14/h3-4,6-8,11-12H,1-2,5,14H2/t7-,8+,11-,12+/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	24	n/a	n/a	n/a	n/a
University of Florence Curated by ChEMBL					Assay Description Agonist activity at human alpha7 nAChR expressed in mouse Neuro2a cells co-expressing chaperone NACHO assessed as increase in intracellular Ca2+ leve...				J Med Chem 62: 1887-1901 (2019) Article DOI: 10.1021/acs.jmedchem.8b01372 BindingDB Entry DOI: 10.7270/Q2PR80F8
					More data for this Ligand-Target Pair