Found 24 hits Enz. Inhib. hit(s) with all data for entry = 50015166 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
5'-nucleotidase
(Homo sapiens (Human)) | BDBM50583394
(CHEMBL5081267)Show SMILES CCN(CC)CC.CCN(CC)CC.Cn1c(=O)n(cc\c1=N\OCc1ccc(I)cc1)[C@@H]1O[C@H](COP(O)(=O)CP(O)(O)=O)[C@@H](O)[C@H]1O |r| | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| 0.436 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human soluble CD73 assessed as inhibition constant |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c01852 BindingDB Entry DOI: 10.7270/Q2ZS31D5 |
More data for this Ligand-Target Pair | |
5'-nucleotidase
(Homo sapiens (Human)) | BDBM50583393
(CHEMBL5083600)Show SMILES CCN(CC)CC.CCN(CC)CC.Cn1c(=O)n(cc\c1=N\OCc1ccc(Br)cc1)[C@@H]1O[C@H](COP(O)(=O)CP(O)(O)=O)[C@@H](O)[C@H]1O |r| | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| 0.441 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human soluble CD73 assessed as inhibition constant |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c01852 BindingDB Entry DOI: 10.7270/Q2ZS31D5 |
More data for this Ligand-Target Pair | |
5'-nucleotidase
(Homo sapiens (Human)) | BDBM50583396
(CHEMBL5074970)Show SMILES CCN(CC)CC.CCN(CC)CC.Cn1c(=O)n(cc\c1=N\OCc1ccc(cc1)S(F)(F)(F)(F)F)[C@@H]1O[C@H](COP(O)(=O)CP(O)(O)=O)[C@@H](O)[C@H]1O |r| | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| 0.511 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human soluble CD73 assessed as inhibition constant |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c01852 BindingDB Entry DOI: 10.7270/Q2ZS31D5 |
More data for this Ligand-Target Pair | |
5'-nucleotidase
(Homo sapiens (Human)) | BDBM50583400
(CHEMBL5078828)Show SMILES CCN(CC)CC.CCN(CC)CC.Cn1c(=O)n(cc\c1=N\OCc1ccc(cc1)C(=O)NCCN)[C@@H]1O[C@H](COP(O)(=O)CP(O)(O)=O)[C@@H](O)[C@H]1O |r| | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| 0.626 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human soluble CD73 assessed as inhibition constant |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c01852 BindingDB Entry DOI: 10.7270/Q2ZS31D5 |
More data for this Ligand-Target Pair | |
5'-nucleotidase
(Homo sapiens (Human)) | BDBM50583392
(CHEMBL5080841)Show SMILES CCN(CC)CC.CCN(CC)CC.Cn1c(=O)n(cc\c1=N\OCc1ccc(Cl)cc1)[C@@H]1O[C@H](COP(O)(=O)CP(O)(O)=O)[C@@H](O)[C@H]1O |r| | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| 0.673 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human soluble CD73 assessed as inhibition constant |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c01852 BindingDB Entry DOI: 10.7270/Q2ZS31D5 |
More data for this Ligand-Target Pair | |
5'-nucleotidase
(Homo sapiens (Human)) | BDBM50583397
(CHEMBL5086866)Show SMILES CCN(CC)CC.CCN(CC)CC.COC(=O)c1ccc(CO\N=c2\ccn([C@@H]3O[C@H](COP(O)(=O)CP(O)(O)=O)[C@@H](O)[C@H]3O)c(=O)n2C)cc1 |r| | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| 0.848 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human soluble CD73 assessed as inhibition constant |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c01852 BindingDB Entry DOI: 10.7270/Q2ZS31D5 |
More data for this Ligand-Target Pair | |
5'-nucleotidase
(Homo sapiens (Human)) | BDBM50583389
(CHEMBL5076916)Show SMILES CCN(CC)CC.CCN(CC)CC.Cc1ccc(CO\N=c2\ccn([C@@H]3O[C@H](COP(O)(=O)CP(O)(O)=O)[C@@H](O)[C@H]3O)c(=O)n2C)cc1 |r| | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| 0.894 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human soluble CD73 assessed as inhibition constant |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c01852 BindingDB Entry DOI: 10.7270/Q2ZS31D5 |
More data for this Ligand-Target Pair | |
5'-nucleotidase
(Homo sapiens (Human)) | BDBM50583391
(CHEMBL5081442)Show SMILES CCN(CC)CC.CCN(CC)CC.Cn1c(=O)n(cc\c1=N\OCc1ccc(F)cc1)[C@@H]1O[C@H](COP(O)(=O)CP(O)(O)=O)[C@@H](O)[C@H]1O |r| | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| 1.10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human soluble CD73 assessed as inhibition constant |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c01852 BindingDB Entry DOI: 10.7270/Q2ZS31D5 |
More data for this Ligand-Target Pair | |
5'-nucleotidase
(Homo sapiens (Human)) | BDBM50583395
(CHEMBL5084248)Show SMILES CCN(CC)CC.CCN(CC)CC.Cn1c(=O)n(cc\c1=N\OCc1ccc(cc1)C(F)(F)F)[C@@H]1O[C@H](COP(O)(=O)CP(O)(O)=O)[C@@H](O)[C@H]1O |r| | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| 1.10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human soluble CD73 assessed as inhibition constant |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c01852 BindingDB Entry DOI: 10.7270/Q2ZS31D5 |
More data for this Ligand-Target Pair | |
5'-nucleotidase
(Homo sapiens (Human)) | BDBM50583388
(CHEMBL5081604)Show SMILES CCN(CC)CC.CCN(CC)CC.Cn1c(=O)n(cc\c1=N\OCc1cccc(c1)C(F)(F)F)[C@@H]1O[C@H](COP(O)(=O)CP(O)(O)=O)[C@@H](O)[C@H]1O |r| | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| 1.30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human soluble CD73 assessed as inhibition constant |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c01852 BindingDB Entry DOI: 10.7270/Q2ZS31D5 |
More data for this Ligand-Target Pair | |
5'-nucleotidase
(Homo sapiens (Human)) | BDBM50583387
(CHEMBL5079813)Show SMILES CCN(CC)CC.CCN(CC)CC.Cn1c(=O)n(cc\c1=N\OCc1cccc(Cl)c1)[C@@H]1O[C@H](COP(O)(=O)CP(O)(O)=O)[C@@H](O)[C@H]1O |r| | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| 1.60 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human soluble CD73 assessed as inhibition constant |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c01852 BindingDB Entry DOI: 10.7270/Q2ZS31D5 |
More data for this Ligand-Target Pair | |
5'-nucleotidase
(Homo sapiens (Human)) | BDBM50583386
(CHEMBL5094601)Show SMILES CCN(CC)CC.CCN(CC)CC.Cn1c(=O)n(cc\c1=N\OCc1ccccc1Cl)[C@@H]1O[C@H](COP(O)(=O)CP(O)(O)=O)[C@@H](O)[C@H]1O |r| | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| 1.60 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human soluble CD73 assessed as inhibition constant |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c01852 BindingDB Entry DOI: 10.7270/Q2ZS31D5 |
More data for this Ligand-Target Pair | |
5'-nucleotidase
(Homo sapiens (Human)) | BDBM50583401
(CHEMBL5089752)Show SMILES CCN(CC)CC.CCN(CC)CC.Cn1c(=O)n(cc\c1=N\OCc1ccc(cc1)C(=O)NCCCCN)[C@@H]1O[C@H](COP(O)(=O)CP(O)(O)=O)[C@@H](O)[C@H]1O |r| | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| 1.80 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human soluble CD73 assessed as inhibition constant |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c01852 BindingDB Entry DOI: 10.7270/Q2ZS31D5 |
More data for this Ligand-Target Pair | |
5'-nucleotidase
(Homo sapiens (Human)) | BDBM50583399
(CHEMBL5076275)Show SMILES CCN(CC)CC.CCN(CC)CC.Cn1c(=O)n(cc\c1=N\OCc1ccc(cc1)C(N)=O)[C@@H]1O[C@H](COP(O)(=O)CP(O)(O)=O)[C@@H](O)[C@H]1O |r| | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| 1.80 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human soluble CD73 assessed as inhibition constant |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c01852 BindingDB Entry DOI: 10.7270/Q2ZS31D5 |
More data for this Ligand-Target Pair | |
5'-nucleotidase
(Homo sapiens (Human)) | BDBM50546335
(CHEMBL4755577)Show SMILES O[C@@H]1[C@@H](COP(O)(=O)CP(O)(O)=O)O[C@H]([C@@H]1O)n1cnc2c(NCc3ccccc3)ncnc12 |r| | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| Purchase
MCE PC cid PC sid PDB UniChem
| PDB Article PubMed
| 2.20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human recombinant soluble CD73 assessed as inhibition constant by radiometric assay |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c01852 BindingDB Entry DOI: 10.7270/Q2ZS31D5 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
5'-nucleotidase
(Homo sapiens (Human)) | BDBM50583402
(CHEMBL5076684)Show SMILES CCN(CC)CC.CCN(CC)CC.CCOC(=O)CCNC(=O)c1ccc(CO\N=c2\ccn([C@@H]3O[C@H](COP(O)(=O)CP(O)(O)=O)[C@@H](O)[C@H]3O)c(=O)n2C)cc1 |r| | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| 2.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human soluble CD73 assessed as inhibition constant |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c01852 BindingDB Entry DOI: 10.7270/Q2ZS31D5 |
More data for this Ligand-Target Pair | |
5'-nucleotidase
(Homo sapiens (Human)) | BDBM50583403
(CHEMBL5070874)Show SMILES CCN(CC)CC.CCN(CC)CC.Cn1c(=O)n(cc\c1=N\OCc1ccc(cc1)C(=O)NCCC(O)=O)[C@@H]1O[C@H](COP(O)(=O)CP(O)(O)=O)[C@@H](O)[C@H]1O |r| | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| 2.60 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human soluble CD73 assessed as inhibition constant |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c01852 BindingDB Entry DOI: 10.7270/Q2ZS31D5 |
More data for this Ligand-Target Pair | |
5'-nucleotidase
(Homo sapiens (Human)) | BDBM50583390
(CHEMBL5093165)Show SMILES CCN(CC)CC.CCN(CC)CC.CCc1ccc(CO\N=c2\ccn([C@@H]3O[C@H](COP(O)(=O)CP(O)(O)=O)[C@@H](O)[C@H]3O)c(=O)n2C)cc1 |r| | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| 3.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human soluble CD73 assessed as inhibition constant |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c01852 BindingDB Entry DOI: 10.7270/Q2ZS31D5 |
More data for this Ligand-Target Pair | |
5'-nucleotidase
(Homo sapiens (Human)) | BDBM50583398
(CHEMBL5092522)Show SMILES CCN(CC)CC.CCN(CC)CC.Cn1c(=O)n(cc\c1=N\OCc1ccc(cc1)C(O)=O)[C@@H]1O[C@H](COP(O)(=O)CP(O)(O)=O)[C@@H](O)[C@H]1O |r| | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| 14 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human soluble CD73 assessed as inhibition constant |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c01852 BindingDB Entry DOI: 10.7270/Q2ZS31D5 |
More data for this Ligand-Target Pair | |
5'-nucleotidase
(Homo sapiens (Human)) | BDBM50583404
(CHEMBL5077925)Show SMILES CCN(CC)CC.CCN(CC)CC.[H][C@]12C[C@@]1(COP(O)(=O)CP(O)(O)=O)[C@@H](O)[C@@H](O)[C@@H]2n1cc\c(=N\OCc2ccc(Cl)cc2)n(C)c1=O |r| | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| 59 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human soluble CD73 assessed as inhibition constant |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c01852 BindingDB Entry DOI: 10.7270/Q2ZS31D5 |
More data for this Ligand-Target Pair | |
5'-nucleotidase
(Homo sapiens (Human)) | BDBM50583405
(CHEMBL5083016)Show SMILES CCN(CC)CC.CCN(CC)CC.Cn1c(=O)n(cc\c1=N\C(=O)NCc1ccccc1)[C@@H]1O[C@H](COP(O)(=O)CP(O)(O)=O)[C@@H](O)[C@H]1O |r| | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| 72 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human soluble CD73 assessed as inhibition constant |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c01852 BindingDB Entry DOI: 10.7270/Q2ZS31D5 |
More data for this Ligand-Target Pair | |
5'-nucleotidase
(Homo sapiens (Human)) | BDBM18136
(ADP, alpha beta-me | AMPCPP | [({[(2R,3S,4R,5R)-5-...)Show SMILES Nc1ncnc2n(cnc12)[C@@H]1O[C@H](COP(O)(=O)CP(O)(O)=O)[C@@H](O)[C@H]1O |r| Show InChI InChI=1S/C11H17N5O9P2/c12-9-6-10(14-2-13-9)16(3-15-6)11-8(18)7(17)5(25-11)1-24-27(22,23)4-26(19,20)21/h2-3,5,7-8,11,17-18H,1,4H2,(H,22,23)(H2,12,13,14)(H2,19,20,21)/t5-,7-,8-,11-/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| Purchase
MCE MMDB PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| 88 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human recombinant soluble CD73 assessed as inhibition constant by radiometric assay |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c01852 BindingDB Entry DOI: 10.7270/Q2ZS31D5 |
More data for this Ligand-Target Pair | |
5'-nucleotidase
(Homo sapiens (Human)) | BDBM50523526
(CHEMBL3606064)Show SMILES O[C@H]1[C@@H](O)[C@@H](O[C@@H]1COP(O)(=O)CP(O)(O)=O)n1cc(F)c(=O)[nH]c1=O |r| Show InChI InChI=1S/C10H15FN2O11P2/c11-4-1-13(10(17)12-8(4)16)9-7(15)6(14)5(24-9)2-23-26(21,22)3-25(18,19)20/h1,5-7,9,14-15H,2-3H2,(H,21,22)(H,12,16,17)(H2,18,19,20)/t5-,6-,7-,9-/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| 2.54E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human soluble CD73 assessed as inhibition constant |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c01852 BindingDB Entry DOI: 10.7270/Q2ZS31D5 |
More data for this Ligand-Target Pair | |
5'-nucleotidase
(Homo sapiens (Human)) | BDBM50583406
(CHEMBL5075093)Show SMILES CCN(CC)CC.CCN(CC)CC.[H][C@]12C[C@@]1(COP(O)(=O)CP(O)(O)=O)[C@@H](O)[C@@H](O)[C@@H]2n1ccc(=O)[nH]c1=O |r| | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| >5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human soluble CD73 assessed as inhibition constant |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c01852 BindingDB Entry DOI: 10.7270/Q2ZS31D5 |
More data for this Ligand-Target Pair | |