Compile Data Set for Download or QSAR

Found 30 hits Enz. Inhib. hit(s) with all data for entry = 3344   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM31647 (tetrahydrobenzothiophene (THBT), 21) Show SMILES CCC1CCc2c(C1)sc(NC(=O)c1ccccc1[N+]([O-])=O)c2C(N)=O Show InChI InChI=1S/C18H19N3O4S/c1-2-10-7-8-12-14(9-10)26-18(15(12)16(19)22)20-17(23)11-5-3-4-6-13(11)21(24)25/h3-6,10H,2,7-9H2,1H3,(H2,19,22)(H,20,23)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	7.5	23
GSK					Assay Description Inhibition of PDE4 is measured using a luminescence-coupled assay system developed by Cambrex. This assay system couples the formation of AMP, derive...				Bioorg Med Chem 17: 5336-41 (2009) Article DOI: 10.1016/j.bmc.2009.03.061 BindingDB Entry DOI: 10.7270/Q21G0JMF
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM31648 (tetrahydrobenzothiophene (THBT), 22) Show SMILES CC(C)(C)C1CCc2c(C1)sc(NC(=O)c1ccccc1[N+]([O-])=O)c2C(N)=O Show InChI InChI=1S/C20H23N3O4S/c1-20(2,3)11-8-9-13-15(10-11)28-19(16(13)17(21)24)22-18(25)12-6-4-5-7-14(12)23(26)27/h4-7,11H,8-10H2,1-3H3,(H2,21,24)(H,22,25)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	25	n/a	n/a	n/a	n/a	7.5	23
GSK					Assay Description Inhibition of PDE4 is measured using a luminescence-coupled assay system developed by Cambrex. This assay system couples the formation of AMP, derive...				Bioorg Med Chem 17: 5336-41 (2009) Article DOI: 10.1016/j.bmc.2009.03.061 BindingDB Entry DOI: 10.7270/Q21G0JMF
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM31637 (tetrahydrobenzothiophene (THBT), 6) Show SMILES CC1CCc2c(C1)sc(NC(=O)c1ccccc1[N+]([O-])=O)c2C(N)=O Show InChI InChI=1S/C17H17N3O4S/c1-9-6-7-11-13(8-9)25-17(14(11)15(18)21)19-16(22)10-4-2-3-5-12(10)20(23)24/h2-5,9H,6-8H2,1H3,(H2,18,21)(H,19,22)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	50	n/a	n/a	n/a	n/a	7.5	23
GSK					Assay Description Inhibition of PDE4 is measured using a luminescence-coupled assay system developed by Cambrex. This assay system couples the formation of AMP, derive...				Bioorg Med Chem 17: 5336-41 (2009) Article DOI: 10.1016/j.bmc.2009.03.061 BindingDB Entry DOI: 10.7270/Q21G0JMF
					More data for this Ligand-Target Pair				3D Structure (crystal)
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM31644 (tetrahydrobenzothiophene (THBT), 23) Show SMILES CC1(C)CCc2c(C1)sc(NC(=O)c1ccccc1[N+]([O-])=O)c2C(N)=O Show InChI InChI=1S/C18H19N3O4S/c1-18(2)8-7-11-13(9-18)26-17(14(11)15(19)22)20-16(23)10-5-3-4-6-12(10)21(24)25/h3-6H,7-9H2,1-2H3,(H2,19,22)(H,20,23)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	50	n/a	n/a	n/a	n/a	7.5	23
GSK					Assay Description Inhibition of PDE4 is measured using a luminescence-coupled assay system developed by Cambrex. This assay system couples the formation of AMP, derive...				Bioorg Med Chem 17: 5336-41 (2009) Article DOI: 10.1016/j.bmc.2009.03.061 BindingDB Entry DOI: 10.7270/Q21G0JMF
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM31638 (tetrahydrobenzothiophene (THBT), 13a) Show SMILES CC(C)(C)C1CCc2c(C1)sc(NC(=O)c1c(F)cccc1F)c2C(N)=O Show InChI InChI=1S/C20H22F2N2O2S/c1-20(2,3)10-7-8-11-14(9-10)27-19(15(11)17(23)25)24-18(26)16-12(21)5-4-6-13(16)22/h4-6,10H,7-9H2,1-3H3,(H2,23,25)(H,24,26)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	79	n/a	n/a	n/a	n/a	7.5	23
GSK					Assay Description Inhibition of PDE4 is measured using a luminescence-coupled assay system developed by Cambrex. This assay system couples the formation of AMP, derive...				Bioorg Med Chem 17: 5336-41 (2009) Article DOI: 10.1016/j.bmc.2009.03.061 BindingDB Entry DOI: 10.7270/Q21G0JMF
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM31649 (tetrahydrobenzothiophene (THBT), 24) Show SMILES CCCC1CCc2c(C1)sc(NC(=O)c1ccccc1[N+]([O-])=O)c2C(N)=O Show InChI InChI=1S/C19H21N3O4S/c1-2-5-11-8-9-13-15(10-11)27-19(16(13)17(20)23)21-18(24)12-6-3-4-7-14(12)22(25)26/h3-4,6-7,11H,2,5,8-10H2,1H3,(H2,20,23)(H,21,24)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	100	n/a	n/a	n/a	n/a	7.5	23
GSK					Assay Description Inhibition of PDE4 is measured using a luminescence-coupled assay system developed by Cambrex. This assay system couples the formation of AMP, derive...				Bioorg Med Chem 17: 5336-41 (2009) Article DOI: 10.1016/j.bmc.2009.03.061 BindingDB Entry DOI: 10.7270/Q21G0JMF
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Homo sapiens (Human))	BDBM31648 (tetrahydrobenzothiophene (THBT), 22) Show SMILES CC(C)(C)C1CCc2c(C1)sc(NC(=O)c1ccccc1[N+]([O-])=O)c2C(N)=O Show InChI InChI=1S/C20H23N3O4S/c1-20(2,3)11-8-9-13-15(10-11)28-19(16(13)17(21)24)22-18(25)12-6-4-5-7-14(12)23(26)27/h4-7,11H,8-10H2,1-3H3,(H2,21,24)(H,22,25)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	126	n/a	n/a	n/a	n/a	7.5	23
GSK					Assay Description Inhibition of PDE4 is measured using a luminescence-coupled assay system developed by Cambrex. This assay system couples the formation of AMP, derive...				Bioorg Med Chem 17: 5336-41 (2009) Article DOI: 10.1016/j.bmc.2009.03.061 BindingDB Entry DOI: 10.7270/Q21G0JMF
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Homo sapiens (Human))	BDBM31647 (tetrahydrobenzothiophene (THBT), 21) Show SMILES CCC1CCc2c(C1)sc(NC(=O)c1ccccc1[N+]([O-])=O)c2C(N)=O Show InChI InChI=1S/C18H19N3O4S/c1-2-10-7-8-12-14(9-10)26-18(15(12)16(19)22)20-17(23)11-5-3-4-6-13(11)21(24)25/h3-6,10H,2,7-9H2,1H3,(H2,19,22)(H,20,23)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	126	n/a	n/a	n/a	n/a	7.5	23
GSK					Assay Description Inhibition of PDE4 is measured using a luminescence-coupled assay system developed by Cambrex. This assay system couples the formation of AMP, derive...				Bioorg Med Chem 17: 5336-41 (2009) Article DOI: 10.1016/j.bmc.2009.03.061 BindingDB Entry DOI: 10.7270/Q21G0JMF
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM31636 (tetrahydrobenzothiophene (THBT), 4) Show SMILES CC(C)(C)C1CCc2c(C1)sc(NC(=O)c1ccncc1)c2C(N)=O Show InChI InChI=1S/C19H23N3O2S/c1-19(2,3)12-4-5-13-14(10-12)25-18(15(13)16(20)23)22-17(24)11-6-8-21-9-7-11/h6-9,12H,4-5,10H2,1-3H3,(H2,20,23)(H,22,24)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	200	n/a	n/a	n/a	n/a	7.5	23
GSK					Assay Description Inhibition of PDE4 is measured using a luminescence-coupled assay system developed by Cambrex. This assay system couples the formation of AMP, derive...				Bioorg Med Chem 17: 5336-41 (2009) Article DOI: 10.1016/j.bmc.2009.03.061 BindingDB Entry DOI: 10.7270/Q21G0JMF
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Homo sapiens (Human))	BDBM31636 (tetrahydrobenzothiophene (THBT), 4) Show SMILES CC(C)(C)C1CCc2c(C1)sc(NC(=O)c1ccncc1)c2C(N)=O Show InChI InChI=1S/C19H23N3O2S/c1-19(2,3)12-4-5-13-14(10-12)25-18(15(13)16(20)23)22-17(24)11-6-8-21-9-7-11/h6-9,12H,4-5,10H2,1-3H3,(H2,20,23)(H,22,24)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	316	n/a	n/a	n/a	n/a	7.5	23
GSK					Assay Description Inhibition of PDE4 is measured using a luminescence-coupled assay system developed by Cambrex. This assay system couples the formation of AMP, derive...				Bioorg Med Chem 17: 5336-41 (2009) Article DOI: 10.1016/j.bmc.2009.03.061 BindingDB Entry DOI: 10.7270/Q21G0JMF
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM31650 (tetrahydrobenzothiophene (THBT), 25) Show SMILES NC(=O)c1c(NC(=O)c2ccccc2[N+]([O-])=O)sc2CC(CCc12)c1ccccc1 Show InChI InChI=1S/C22H19N3O4S/c23-20(26)19-16-11-10-14(13-6-2-1-3-7-13)12-18(16)30-22(19)24-21(27)15-8-4-5-9-17(15)25(28)29/h1-9,14H,10-12H2,(H2,23,26)(H,24,27)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	398	n/a	n/a	n/a	n/a	7.5	23
GSK					Assay Description Inhibition of PDE4 is measured using a luminescence-coupled assay system developed by Cambrex. This assay system couples the formation of AMP, derive...				Bioorg Med Chem 17: 5336-41 (2009) Article DOI: 10.1016/j.bmc.2009.03.061 BindingDB Entry DOI: 10.7270/Q21G0JMF
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Homo sapiens (Human))	BDBM31644 (tetrahydrobenzothiophene (THBT), 23) Show SMILES CC1(C)CCc2c(C1)sc(NC(=O)c1ccccc1[N+]([O-])=O)c2C(N)=O Show InChI InChI=1S/C18H19N3O4S/c1-18(2)8-7-11-13(9-18)26-17(14(11)15(19)22)20-16(23)10-5-3-4-6-12(10)21(24)25/h3-6H,7-9H2,1-2H3,(H2,19,22)(H,20,23)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	398	n/a	n/a	n/a	n/a	7.5	23
GSK					Assay Description Inhibition of PDE4 is measured using a luminescence-coupled assay system developed by Cambrex. This assay system couples the formation of AMP, derive...				Bioorg Med Chem 17: 5336-41 (2009) Article DOI: 10.1016/j.bmc.2009.03.061 BindingDB Entry DOI: 10.7270/Q21G0JMF
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Homo sapiens (Human))	BDBM31637 (tetrahydrobenzothiophene (THBT), 6) Show SMILES CC1CCc2c(C1)sc(NC(=O)c1ccccc1[N+]([O-])=O)c2C(N)=O Show InChI InChI=1S/C17H17N3O4S/c1-9-6-7-11-13(8-9)25-17(14(11)15(18)21)19-16(22)10-4-2-3-5-12(10)20(23)24/h2-5,9H,6-8H2,1H3,(H2,18,21)(H,19,22)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	501	n/a	n/a	n/a	n/a	7.5	23
GSK					Assay Description Inhibition of PDE4 is measured using a luminescence-coupled assay system developed by Cambrex. This assay system couples the formation of AMP, derive...				Bioorg Med Chem 17: 5336-41 (2009) Article DOI: 10.1016/j.bmc.2009.03.061 BindingDB Entry DOI: 10.7270/Q21G0JMF
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM31640 (tetrahydrobenzothiophene (THBT), 14) Show SMILES CC1CCc2c(C1)sc(NC(=O)c1cccc(c1)[N+]([O-])=O)c2C(N)=O Show InChI InChI=1S/C17H17N3O4S/c1-9-5-6-12-13(7-9)25-17(14(12)15(18)21)19-16(22)10-3-2-4-11(8-10)20(23)24/h2-4,8-9H,5-7H2,1H3,(H2,18,21)(H,19,22)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	631	n/a	n/a	n/a	n/a	7.5	23
GSK					Assay Description Inhibition of PDE4 is measured using a luminescence-coupled assay system developed by Cambrex. This assay system couples the formation of AMP, derive...				Bioorg Med Chem 17: 5336-41 (2009) Article DOI: 10.1016/j.bmc.2009.03.061 BindingDB Entry DOI: 10.7270/Q21G0JMF
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM31646 (tetrahydrobenzothiophene (THBT), 20) Show SMILES CC(C)(C)C1CCc2sc(NC(=O)c3ccccc3[N+]([O-])=O)c(C(N)=O)c2C1 Show InChI InChI=1S/C20H23N3O4S/c1-20(2,3)11-8-9-15-13(10-11)16(17(21)24)19(28-15)22-18(25)12-6-4-5-7-14(12)23(26)27/h4-7,11H,8-10H2,1-3H3,(H2,21,24)(H,22,25)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.26E+3	n/a	n/a	n/a	n/a	7.5	23
GSK					Assay Description Inhibition of PDE4 is measured using a luminescence-coupled assay system developed by Cambrex. This assay system couples the formation of AMP, derive...				Bioorg Med Chem 17: 5336-41 (2009) Article DOI: 10.1016/j.bmc.2009.03.061 BindingDB Entry DOI: 10.7270/Q21G0JMF
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM31642 (tetrahydrobenzothiophene (THBT), 16) Show SMILES NC(=O)c1c(NC(=O)c2ccccc2[N+]([O-])=O)sc2CCCCc12 Show InChI InChI=1S/C16H15N3O4S/c17-14(20)13-10-6-2-4-8-12(10)24-16(13)18-15(21)9-5-1-3-7-11(9)19(22)23/h1,3,5,7H,2,4,6,8H2,(H2,17,20)(H,18,21)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.26E+3	n/a	n/a	n/a	n/a	7.5	23
GSK					Assay Description Inhibition of PDE4 is measured using a luminescence-coupled assay system developed by Cambrex. This assay system couples the formation of AMP, derive...				Bioorg Med Chem 17: 5336-41 (2009) Article DOI: 10.1016/j.bmc.2009.03.061 BindingDB Entry DOI: 10.7270/Q21G0JMF
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Homo sapiens (Human))	BDBM31650 (tetrahydrobenzothiophene (THBT), 25) Show SMILES NC(=O)c1c(NC(=O)c2ccccc2[N+]([O-])=O)sc2CC(CCc12)c1ccccc1 Show InChI InChI=1S/C22H19N3O4S/c23-20(26)19-16-11-10-14(13-6-2-1-3-7-13)12-18(16)30-22(19)24-21(27)15-8-4-5-9-17(15)25(28)29/h1-9,14H,10-12H2,(H2,23,26)(H,24,27)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.59E+3	n/a	n/a	n/a	n/a	7.5	23
GSK					Assay Description Inhibition of PDE4 is measured using a luminescence-coupled assay system developed by Cambrex. This assay system couples the formation of AMP, derive...				Bioorg Med Chem 17: 5336-41 (2009) Article DOI: 10.1016/j.bmc.2009.03.061 BindingDB Entry DOI: 10.7270/Q21G0JMF
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM31645 (tetrahydrobenzothiophene (THBT), 19) Show SMILES CC1CCc2sc(NC(=O)c3ccccc3[N+]([O-])=O)c(C(N)=O)c2C1 Show InChI InChI=1S/C17H17N3O4S/c1-9-6-7-13-11(8-9)14(15(18)21)17(25-13)19-16(22)10-4-2-3-5-12(10)20(23)24/h2-5,9H,6-8H2,1H3,(H2,18,21)(H,19,22)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.00E+3	n/a	n/a	n/a	n/a	7.5	23
GSK					Assay Description Inhibition of PDE4 is measured using a luminescence-coupled assay system developed by Cambrex. This assay system couples the formation of AMP, derive...				Bioorg Med Chem 17: 5336-41 (2009) Article DOI: 10.1016/j.bmc.2009.03.061 BindingDB Entry DOI: 10.7270/Q21G0JMF
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Homo sapiens (Human))	BDBM31649 (tetrahydrobenzothiophene (THBT), 24) Show SMILES CCCC1CCc2c(C1)sc(NC(=O)c1ccccc1[N+]([O-])=O)c2C(N)=O Show InChI InChI=1S/C19H21N3O4S/c1-2-5-11-8-9-13-15(10-11)27-19(16(13)17(20)23)21-18(24)12-6-3-4-7-14(12)22(25)26/h3-4,6-7,11H,2,5,8-10H2,1H3,(H2,20,23)(H,21,24)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.51E+3	n/a	n/a	n/a	n/a	7.5	23
GSK					Assay Description Inhibition of PDE4 is measured using a luminescence-coupled assay system developed by Cambrex. This assay system couples the formation of AMP, derive...				Bioorg Med Chem 17: 5336-41 (2009) Article DOI: 10.1016/j.bmc.2009.03.061 BindingDB Entry DOI: 10.7270/Q21G0JMF
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Homo sapiens (Human))	BDBM31651 (tetrahydrobenzothiophene (THBT), 18) Show SMILES Cc1cccc(C)c1C(=O)C1CCCc2sc(NC(=O)c3ccccc3[N+]([O-])=O)c(C(N)=O)c12 Show InChI InChI=1S/C25H23N3O5S/c1-13-7-5-8-14(2)19(13)22(29)16-10-6-12-18-20(16)21(23(26)30)25(34-18)27-24(31)15-9-3-4-11-17(15)28(32)33/h3-5,7-9,11,16H,6,10,12H2,1-2H3,(H2,26,30)(H,27,31)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.51E+3	n/a	n/a	n/a	n/a	7.5	23
GSK					Assay Description Inhibition of PDE4 is measured using a luminescence-coupled assay system developed by Cambrex. This assay system couples the formation of AMP, derive...				Bioorg Med Chem 17: 5336-41 (2009) Article DOI: 10.1016/j.bmc.2009.03.061 BindingDB Entry DOI: 10.7270/Q21G0JMF
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Homo sapiens (Human))	BDBM31641 (tetrahydrobenzothiophene (THBT), 15) Show SMILES CC1CCc2c(C1)sc(NC(=O)c1ccc(cc1)[N+]([O-])=O)c2C(N)=O Show InChI InChI=1S/C17H17N3O4S/c1-9-2-7-12-13(8-9)25-17(14(12)15(18)21)19-16(22)10-3-5-11(6-4-10)20(23)24/h3-6,9H,2,7-8H2,1H3,(H2,18,21)(H,19,22)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>2.51E+3	n/a	n/a	n/a	n/a	7.5	23
GSK					Assay Description Inhibition of PDE4 is measured using a luminescence-coupled assay system developed by Cambrex. This assay system couples the formation of AMP, derive...				Bioorg Med Chem 17: 5336-41 (2009) Article DOI: 10.1016/j.bmc.2009.03.061 BindingDB Entry DOI: 10.7270/Q21G0JMF
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Homo sapiens (Human))	BDBM31640 (tetrahydrobenzothiophene (THBT), 14) Show SMILES CC1CCc2c(C1)sc(NC(=O)c1cccc(c1)[N+]([O-])=O)c2C(N)=O Show InChI InChI=1S/C17H17N3O4S/c1-9-5-6-12-13(7-9)25-17(14(12)15(18)21)19-16(22)10-3-2-4-11(8-10)20(23)24/h2-4,8-9H,5-7H2,1H3,(H2,18,21)(H,19,22)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>2.51E+3	n/a	n/a	n/a	n/a	7.5	23
GSK					Assay Description Inhibition of PDE4 is measured using a luminescence-coupled assay system developed by Cambrex. This assay system couples the formation of AMP, derive...				Bioorg Med Chem 17: 5336-41 (2009) Article DOI: 10.1016/j.bmc.2009.03.061 BindingDB Entry DOI: 10.7270/Q21G0JMF
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM31641 (tetrahydrobenzothiophene (THBT), 15) Show SMILES CC1CCc2c(C1)sc(NC(=O)c1ccc(cc1)[N+]([O-])=O)c2C(N)=O Show InChI InChI=1S/C17H17N3O4S/c1-9-2-7-12-13(8-9)25-17(14(12)15(18)21)19-16(22)10-3-5-11(6-4-10)20(23)24/h3-6,9H,2,7-8H2,1H3,(H2,18,21)(H,19,22)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>2.51E+3	n/a	n/a	n/a	n/a	7.5	23
GSK					Assay Description Inhibition of PDE4 is measured using a luminescence-coupled assay system developed by Cambrex. This assay system couples the formation of AMP, derive...				Bioorg Med Chem 17: 5336-41 (2009) Article DOI: 10.1016/j.bmc.2009.03.061 BindingDB Entry DOI: 10.7270/Q21G0JMF
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM31651 (tetrahydrobenzothiophene (THBT), 18) Show SMILES Cc1cccc(C)c1C(=O)C1CCCc2sc(NC(=O)c3ccccc3[N+]([O-])=O)c(C(N)=O)c12 Show InChI InChI=1S/C25H23N3O5S/c1-13-7-5-8-14(2)19(13)22(29)16-10-6-12-18-20(16)21(23(26)30)25(34-18)27-24(31)15-9-3-4-11-17(15)28(32)33/h3-5,7-9,11,16H,6,10,12H2,1-2H3,(H2,26,30)(H,27,31)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.01E+3	n/a	n/a	n/a	n/a	7.5	23
GSK					Assay Description Inhibition of PDE4 is measured using a luminescence-coupled assay system developed by Cambrex. This assay system couples the formation of AMP, derive...				Bioorg Med Chem 17: 5336-41 (2009) Article DOI: 10.1016/j.bmc.2009.03.061 BindingDB Entry DOI: 10.7270/Q21G0JMF
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM31643 (tetrahydrobenzothiophene (THBT), 17) Show SMILES CC1CCCc2sc(NC(=O)c3ccccc3[N+]([O-])=O)c(C(N)=O)c12 Show InChI InChI=1S/C17H17N3O4S/c1-9-5-4-8-12-13(9)14(15(18)21)17(25-12)19-16(22)10-6-2-3-7-11(10)20(23)24/h2-3,6-7,9H,4-5,8H2,1H3,(H2,18,21)(H,19,22)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.01E+3	n/a	n/a	n/a	n/a	7.5	23
GSK					Assay Description Inhibition of PDE4 is measured using a luminescence-coupled assay system developed by Cambrex. This assay system couples the formation of AMP, derive...				Bioorg Med Chem 17: 5336-41 (2009) Article DOI: 10.1016/j.bmc.2009.03.061 BindingDB Entry DOI: 10.7270/Q21G0JMF
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Homo sapiens (Human))	BDBM31645 (tetrahydrobenzothiophene (THBT), 19) Show SMILES CC1CCc2sc(NC(=O)c3ccccc3[N+]([O-])=O)c(C(N)=O)c2C1 Show InChI InChI=1S/C17H17N3O4S/c1-9-6-7-13-11(8-9)14(15(18)21)17(25-13)19-16(22)10-4-2-3-5-12(10)20(23)24/h2-5,9H,6-8H2,1H3,(H2,18,21)(H,19,22)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.31E+3	n/a	n/a	n/a	n/a	7.5	23
GSK					Assay Description Inhibition of PDE4 is measured using a luminescence-coupled assay system developed by Cambrex. This assay system couples the formation of AMP, derive...				Bioorg Med Chem 17: 5336-41 (2009) Article DOI: 10.1016/j.bmc.2009.03.061 BindingDB Entry DOI: 10.7270/Q21G0JMF
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Homo sapiens (Human))	BDBM31642 (tetrahydrobenzothiophene (THBT), 16) Show SMILES NC(=O)c1c(NC(=O)c2ccccc2[N+]([O-])=O)sc2CCCCc12 Show InChI InChI=1S/C16H15N3O4S/c17-14(20)13-10-6-2-4-8-12(10)24-16(13)18-15(21)9-5-1-3-7-11(9)19(22)23/h1,3,5,7H,2,4,6,8H2,(H2,17,20)(H,18,21)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.31E+3	n/a	n/a	n/a	n/a	7.5	23
GSK					Assay Description Inhibition of PDE4 is measured using a luminescence-coupled assay system developed by Cambrex. This assay system couples the formation of AMP, derive...				Bioorg Med Chem 17: 5336-41 (2009) Article DOI: 10.1016/j.bmc.2009.03.061 BindingDB Entry DOI: 10.7270/Q21G0JMF
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Homo sapiens (Human))	BDBM31646 (tetrahydrobenzothiophene (THBT), 20) Show SMILES CC(C)(C)C1CCc2sc(NC(=O)c3ccccc3[N+]([O-])=O)c(C(N)=O)c2C1 Show InChI InChI=1S/C20H23N3O4S/c1-20(2,3)11-8-9-15-13(10-11)16(17(21)24)19(28-15)22-18(25)12-6-4-5-7-14(12)23(26)27/h4-7,11H,8-10H2,1-3H3,(H2,21,24)(H,22,25)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.31E+3	n/a	n/a	n/a	n/a	7.5	23
GSK					Assay Description Inhibition of PDE4 is measured using a luminescence-coupled assay system developed by Cambrex. This assay system couples the formation of AMP, derive...				Bioorg Med Chem 17: 5336-41 (2009) Article DOI: 10.1016/j.bmc.2009.03.061 BindingDB Entry DOI: 10.7270/Q21G0JMF
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM31639 (tetrahydrobenzothiophene (THBT), 13b) Show SMILES CNC(=O)c1c(NC(=O)c2c(F)cccc2F)sc2CC(CCc12)C(C)(C)C Show InChI InChI=1S/C21H24F2N2O2S/c1-21(2,3)11-8-9-12-15(10-11)28-20(16(12)18(26)24-4)25-19(27)17-13(22)6-5-7-14(17)23/h5-7,11H,8-10H2,1-4H3,(H,24,26)(H,25,27)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	7.5	23
GSK					Assay Description Inhibition of PDE4 is measured using a luminescence-coupled assay system developed by Cambrex. This assay system couples the formation of AMP, derive...				Bioorg Med Chem 17: 5336-41 (2009) Article DOI: 10.1016/j.bmc.2009.03.061 BindingDB Entry DOI: 10.7270/Q21G0JMF
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Homo sapiens (Human))	BDBM31643 (tetrahydrobenzothiophene (THBT), 17) Show SMILES CC1CCCc2sc(NC(=O)c3ccccc3[N+]([O-])=O)c(C(N)=O)c12 Show InChI InChI=1S/C17H17N3O4S/c1-9-5-4-8-12-13(9)14(15(18)21)17(25-12)19-16(22)10-6-2-3-7-11(10)20(23)24/h2-3,6-7,9H,4-5,8H2,1H3,(H2,18,21)(H,19,22)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.16E+4	n/a	n/a	n/a	n/a	7.5	23
GSK					Assay Description Inhibition of PDE4 is measured using a luminescence-coupled assay system developed by Cambrex. This assay system couples the formation of AMP, derive...				Bioorg Med Chem 17: 5336-41 (2009) Article DOI: 10.1016/j.bmc.2009.03.061 BindingDB Entry DOI: 10.7270/Q21G0JMF
					More data for this Ligand-Target Pair