Reaction Details |
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Target | cAMP-specific 3',5'-cyclic phosphodiesterase 4D |
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Ligand | BDBM31643 |
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Substrate/Competitor | BDBM10851 |
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Meas. Tech. | Enzyme Inhibition Assay |
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pH | 7.5±n/a |
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Temperature | 296.15±n/a K |
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IC50 | 31623±n/a nM |
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Citation | Kranz, M; Wall, M; Evans, B; Miah, A; Ballantine, S; Delves, C; Dombroski, B; Gross, J; Schneck, J; Villa, JP; Neu, M; Somers, DO Identification of PDE4B Over 4D subtype-selective inhibitors revealing an unprecedented binding mode. Bioorg Med Chem17:5336-41 (2009) [PubMed] Article |
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More Info.: | Get all data from this article, Inhibition_Run data, Solution Info, Assay Method |
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cAMP-specific 3',5'-cyclic phosphodiesterase 4D |
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Name: | cAMP-specific 3',5'-cyclic phosphodiesterase 4D |
Synonyms: | 3',5'-cyclic phosphodiesterase | DPDE3 | PDE43 | PDE4D | PDE4D_HUMAN | Phosphodiesterase 4D |
Type: | Protein |
Mol. Mass.: | 91092.69 |
Organism: | Homo sapiens (Human) |
Description: | Q08499 |
Residue: | 809 |
Sequence: | MEAEGSSAPARAGSGEGSDSAGGATLKAPKHLWRHEQHHQYPLRQPQFRLLHPHHHLPPP
PPPSPQPQPQCPLQPPPPPPLPPPPPPPGAARGRYASSGATGRVRHRGYSDTERYLYCRA
MDRTSYAVETGHRPGLKKSRMSWPSSFQGLRRFDVDNGTSAGRSPLDPMTSPGSGLILQA
NFVHSQRRESFLYRSDSDYDLSPKSMSRNSSIASDIHGDDLIVTPFAQVLASLRTVRNNF
AALTNLQDRAPSKRSPMCNQPSINKATITEEAYQKLASETLEELDWCLDQLETLQTRHSV
SEMASNKFKRMLNRELTHLSEMSRSGNQVSEFISNTFLDKQHEVEIPSPTQKEKEKKKRP
MSQISGVKKLMHSSSLTNSSIPRFGVKTEQEDVLAKELEDVNKWGLHVFRIAELSGNRPL
TVIMHTIFQERDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVLLST
PALEAVFTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGF
KLLQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTMVETKKVTSSGVL
LLDNYSDRIQVLQNMVHCADLSNPTKPLQLYRQWTDRIMEEFFRQGDRERERGMEISPMC
DKHNASVEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLEDNREWYQSTIPQSPSPAP
DDPEEGRQGQTEKFQFELTLEEDGESDTEKDSGSQVEEDTSCSDSKTLCTQDSESTEIPL
DEQVEEEAVGEEEESQPEACVIDDRSPDT
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BDBM31643 |
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BDBM10851 |
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Name | BDBM31643 |
Synonyms: | tetrahydrobenzothiophene (THBT), 17 |
Type | Small organic molecule |
Emp. Form. | C17H17N3O4S |
Mol. Mass. | 359.4 |
SMILES | CC1CCCc2sc(NC(=O)c3ccccc3[N+]([O-])=O)c(C(N)=O)c12 |
Structure |
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