Compile Data Set for Download or QSAR

Found 234 hits Enz. Inhib. hit(s) with all data for entry = 9243   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase 4 (Homo sapiens (Human))	BDBM451711 (6-(2-amino-5-(2-fluoro-5- nitrophenyl)pyridin-3-yl...) Show SMILES Nc1ncc(cc1-c1ccc2C(=O)NCCc2c1)-c1cc(ccc1F)[N+]([O-])=O Show InChI InChI=1S/C20H15FN4O3/c21-18-4-2-14(25(27)28)9-16(18)13-8-17(19(22)24-10-13)11-1-3-15-12(7-11)5-6-23-20(15)26/h1-4,7-10H,5-6H2,(H2,22,24)(H,23,26)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<40	n/a	n/a	n/a	n/a	n/a	n/a
DANA-FARBER CANCER INSTITUTE, INC.; FONDAZIONE CENTRO SAN RAFFAELE US Patent					Assay Description Biochemical IC50s were measured at Invitrogen using Z-lyte technology. Briefly, for STK4, the 2×STK4 (MST1)/Ser/Thr 07 mixture was prepared in 50 mM ...				US Patent US10710978 (2020) BindingDB Entry DOI: 10.7270/Q2J67KZW
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase 4 (Homo sapiens (Human))	BDBM451768 (US10710978, Compound KIN00I-305) Show SMILES CN(C1CC1)S(=O)(=O)c1ccc(cc1)-c1cnc(N)c(c1)-c1ccc2C(=O)NCCc2c1 Show InChI InChI=1S/C24H24N4O3S/c1-28(19-5-6-19)32(30,31)20-7-2-15(3-8-20)18-13-22(23(25)27-14-18)16-4-9-21-17(12-16)10-11-26-24(21)29/h2-4,7-9,12-14,19H,5-6,10-11H2,1H3,(H2,25,27)(H,26,29)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<40	n/a	n/a	n/a	n/a	n/a	n/a
DANA-FARBER CANCER INSTITUTE, INC.; FONDAZIONE CENTRO SAN RAFFAELE US Patent					Assay Description Biochemical IC50s were measured at Invitrogen using Z-lyte technology. Briefly, for STK4, the 2×STK4 (MST1)/Ser/Thr 07 mixture was prepared in 50 mM ...				US Patent US10710978 (2020) BindingDB Entry DOI: 10.7270/Q2J67KZW
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase 4 (Homo sapiens (Human))	BDBM451719 (6-(2-amino-5-(2-fluoro-3- nitrophenyl)pyridin-3-yl...) Show SMILES Nc1ncc(cc1-c1ccc2C(=O)NCCc2c1)-c1cccc(c1F)[N+]([O-])=O Show InChI InChI=1S/C20H15FN4O3/c21-18-14(2-1-3-17(18)25(27)28)13-9-16(19(22)24-10-13)11-4-5-15-12(8-11)6-7-23-20(15)26/h1-5,8-10H,6-7H2,(H2,22,24)(H,23,26)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<40	n/a	n/a	n/a	n/a	n/a	n/a
DANA-FARBER CANCER INSTITUTE, INC.; FONDAZIONE CENTRO SAN RAFFAELE US Patent					Assay Description Biochemical IC50s were measured at Invitrogen using Z-lyte technology. Briefly, for STK4, the 2×STK4 (MST1)/Ser/Thr 07 mixture was prepared in 50 mM ...				US Patent US10710978 (2020) BindingDB Entry DOI: 10.7270/Q2J67KZW
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase 3 (Homo sapiens (Human))	BDBM451719 (6-(2-amino-5-(2-fluoro-3- nitrophenyl)pyridin-3-yl...) Show SMILES Nc1ncc(cc1-c1ccc2C(=O)NCCc2c1)-c1cccc(c1F)[N+]([O-])=O Show InChI InChI=1S/C20H15FN4O3/c21-18-14(2-1-3-17(18)25(27)28)13-9-16(19(22)24-10-13)11-4-5-15-12(8-11)6-7-23-20(15)26/h1-5,8-10H,6-7H2,(H2,22,24)(H,23,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<40	n/a	n/a	n/a	n/a	n/a	n/a
DANA-FARBER CANCER INSTITUTE, INC.; FONDAZIONE CENTRO SAN RAFFAELE US Patent					Assay Description Biochemical IC50s were measured at Invitrogen using Z-lyte technology. Briefly, for STK4, the 2×STK4 (MST1)/Ser/Thr 07 mixture was prepared in 50 mM ...				US Patent US10710978 (2020) BindingDB Entry DOI: 10.7270/Q2J67KZW
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase 4 (Homo sapiens (Human))	BDBM451722 (6-(2-amino-5- (benzo[d]thiazol-7-yl)pyridin- 3-yl)...) Show SMILES Nc1ncc(cc1-c1ccc2C(=O)NCCc2c1)-c1cccc2ncsc12 Show InChI InChI=1S/C21H16N4OS/c22-20-17(12-4-5-16-13(8-12)6-7-23-21(16)26)9-14(10-24-20)15-2-1-3-18-19(15)27-11-25-18/h1-5,8-11H,6-7H2,(H2,22,24)(H,23,26)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<40	n/a	n/a	n/a	n/a	n/a	n/a
DANA-FARBER CANCER INSTITUTE, INC.; FONDAZIONE CENTRO SAN RAFFAELE US Patent					Assay Description Biochemical IC50s were measured at Invitrogen using Z-lyte technology. Briefly, for STK4, the 2×STK4 (MST1)/Ser/Thr 07 mixture was prepared in 50 mM ...				US Patent US10710978 (2020) BindingDB Entry DOI: 10.7270/Q2J67KZW
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase 4 (Homo sapiens (Human))	BDBM451724 (6-(2-amino-5- (benzo[b]thiophen-4- yl)pyridin-3-yl...) Show SMILES Nc1ncc(cc1-c1ccc2C(=O)NCCc2c1)-c1cccc2sccc12 Show InChI InChI=1S/C22H17N3OS/c23-21-19(13-4-5-17-14(10-13)6-8-24-22(17)26)11-15(12-25-21)16-2-1-3-20-18(16)7-9-27-20/h1-5,7,9-12H,6,8H2,(H2,23,25)(H,24,26)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<40	n/a	n/a	n/a	n/a	n/a	n/a
DANA-FARBER CANCER INSTITUTE, INC.; FONDAZIONE CENTRO SAN RAFFAELE US Patent					Assay Description Biochemical IC50s were measured at Invitrogen using Z-lyte technology. Briefly, for STK4, the 2×STK4 (MST1)/Ser/Thr 07 mixture was prepared in 50 mM ...				US Patent US10710978 (2020) BindingDB Entry DOI: 10.7270/Q2J67KZW
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase 4 (Homo sapiens (Human))	BDBM451728 (6-(6-amino-5-(1-oxo-1,2,3,4- tetrahydroisoquinolin...) Show SMILES Nc1ncc(cc1-c1ccc2C(=O)NCCc2c1)-c1cc2NC(=O)COc2cc1F Show InChI InChI=1S/C22H17FN4O3/c23-17-8-19-18(27-20(28)10-30-19)7-15(17)13-6-16(21(24)26-9-13)11-1-2-14-12(5-11)3-4-25-22(14)29/h1-2,5-9H,3-4,10H2,(H2,24,26)(H,25,29)(H,27,28)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<40	n/a	n/a	n/a	n/a	n/a	n/a
DANA-FARBER CANCER INSTITUTE, INC.; FONDAZIONE CENTRO SAN RAFFAELE US Patent					Assay Description Biochemical IC50s were measured at Invitrogen using Z-lyte technology. Briefly, for STK4, the 2×STK4 (MST1)/Ser/Thr 07 mixture was prepared in 50 mM ...				US Patent US10710978 (2020) BindingDB Entry DOI: 10.7270/Q2J67KZW
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase 4 (Homo sapiens (Human))	BDBM451730 (4-(6-amino-5-(1-oxo-1,2,3,4- tetrahydroisoquinolin...) Show SMILES CN(C1CC1)S(=O)(=O)c1ccc(c(F)c1)-c1cnc(N)c(c1)-c1ccc2C(=O)NCCc2c1 Show InChI InChI=1S/C24H23FN4O3S/c1-29(17-3-4-17)33(31,32)18-5-7-19(22(25)12-18)16-11-21(23(26)28-13-16)14-2-6-20-15(10-14)8-9-27-24(20)30/h2,5-7,10-13,17H,3-4,8-9H2,1H3,(H2,26,28)(H,27,30)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<40	n/a	n/a	n/a	n/a	n/a	n/a
DANA-FARBER CANCER INSTITUTE, INC.; FONDAZIONE CENTRO SAN RAFFAELE US Patent					Assay Description Biochemical IC50s were measured at Invitrogen using Z-lyte technology. Briefly, for STK4, the 2×STK4 (MST1)/Ser/Thr 07 mixture was prepared in 50 mM ...				US Patent US10710978 (2020) BindingDB Entry DOI: 10.7270/Q2J67KZW
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase 3 (Homo sapiens (Human))	BDBM451730 (4-(6-amino-5-(1-oxo-1,2,3,4- tetrahydroisoquinolin...) Show SMILES CN(C1CC1)S(=O)(=O)c1ccc(c(F)c1)-c1cnc(N)c(c1)-c1ccc2C(=O)NCCc2c1 Show InChI InChI=1S/C24H23FN4O3S/c1-29(17-3-4-17)33(31,32)18-5-7-19(22(25)12-18)16-11-21(23(26)28-13-16)14-2-6-20-15(10-14)8-9-27-24(20)30/h2,5-7,10-13,17H,3-4,8-9H2,1H3,(H2,26,28)(H,27,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<40	n/a	n/a	n/a	n/a	n/a	n/a
DANA-FARBER CANCER INSTITUTE, INC.; FONDAZIONE CENTRO SAN RAFFAELE US Patent					Assay Description Biochemical IC50s were measured at Invitrogen using Z-lyte technology. Briefly, for STK4, the 2×STK4 (MST1)/Ser/Thr 07 mixture was prepared in 50 mM ...				US Patent US10710978 (2020) BindingDB Entry DOI: 10.7270/Q2J67KZW
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase 4 (Homo sapiens (Human))	BDBM451736 (4-(6-amino-5-(1-oxo-1,2,3,4- tetrahydroisoquinolin...) Show SMILES CN(C1CC1)S(=O)(=O)c1ccc(c(C)c1)-c1cnc(N)c(c1)-c1ccc2C(=O)NCCc2c1 Show InChI InChI=1S/C25H26N4O3S/c1-15-11-20(33(31,32)29(2)19-4-5-19)6-8-21(15)18-13-23(24(26)28-14-18)16-3-7-22-17(12-16)9-10-27-25(22)30/h3,6-8,11-14,19H,4-5,9-10H2,1-2H3,(H2,26,28)(H,27,30)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<40	n/a	n/a	n/a	n/a	n/a	n/a
DANA-FARBER CANCER INSTITUTE, INC.; FONDAZIONE CENTRO SAN RAFFAELE US Patent					Assay Description Biochemical IC50s were measured at Invitrogen using Z-lyte technology. Briefly, for STK4, the 2×STK4 (MST1)/Ser/Thr 07 mixture was prepared in 50 mM ...				US Patent US10710978 (2020) BindingDB Entry DOI: 10.7270/Q2J67KZW
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase 4 (Homo sapiens (Human))	BDBM451737 (4-(6-amino-5-(1-oxo-1,2,3,4- tetrahydroisoquinolin...) Show SMILES CCOc1cc(ccc1-c1cnc(N)c(c1)-c1ccc2C(=O)NCCc2c1)S(=O)(=O)N(C)C1CC1 Show InChI InChI=1S/C26H28N4O4S/c1-3-34-24-14-20(35(32,33)30(2)19-5-6-19)7-9-21(24)18-13-23(25(27)29-15-18)16-4-8-22-17(12-16)10-11-28-26(22)31/h4,7-9,12-15,19H,3,5-6,10-11H2,1-2H3,(H2,27,29)(H,28,31)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<40	n/a	n/a	n/a	n/a	n/a	n/a
DANA-FARBER CANCER INSTITUTE, INC.; FONDAZIONE CENTRO SAN RAFFAELE US Patent					Assay Description Biochemical IC50s were measured at Invitrogen using Z-lyte technology. Briefly, for STK4, the 2×STK4 (MST1)/Ser/Thr 07 mixture was prepared in 50 mM ...				US Patent US10710978 (2020) BindingDB Entry DOI: 10.7270/Q2J67KZW
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase 4 (Homo sapiens (Human))	BDBM451738 (4-(6-amino-5-(1-oxo-1,2,3,4- tetrahydroisoquinolin...) Show SMILES CC(C)Oc1cc(ccc1-c1cnc(N)c(c1)-c1ccc2C(=O)NCCc2c1)S(=O)(=O)N(C)C1CC1 Show InChI InChI=1S/C27H30N4O4S/c1-16(2)35-25-14-21(36(33,34)31(3)20-5-6-20)7-9-22(25)19-13-24(26(28)30-15-19)17-4-8-23-18(12-17)10-11-29-27(23)32/h4,7-9,12-16,20H,5-6,10-11H2,1-3H3,(H2,28,30)(H,29,32)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<40	n/a	n/a	n/a	n/a	n/a	n/a
DANA-FARBER CANCER INSTITUTE, INC.; FONDAZIONE CENTRO SAN RAFFAELE US Patent					Assay Description Biochemical IC50s were measured at Invitrogen using Z-lyte technology. Briefly, for STK4, the 2×STK4 (MST1)/Ser/Thr 07 mixture was prepared in 50 mM ...				US Patent US10710978 (2020) BindingDB Entry DOI: 10.7270/Q2J67KZW
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase 4 (Homo sapiens (Human))	BDBM451739 (4-(6-amino-5-(1-oxo-1,2,3,4- tetrahydroisoquinolin...) Show SMILES COc1cc(ccc1-c1cnc(N)c(c1)-c1ccc2C(=O)NCCc2c1)S(=O)(=O)NC1CC1 Show InChI InChI=1S/C24H24N4O4S/c1-32-22-12-18(33(30,31)28-17-3-4-17)5-7-19(22)16-11-21(23(25)27-13-16)14-2-6-20-15(10-14)8-9-26-24(20)29/h2,5-7,10-13,17,28H,3-4,8-9H2,1H3,(H2,25,27)(H,26,29)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<40	n/a	n/a	n/a	n/a	n/a	n/a
DANA-FARBER CANCER INSTITUTE, INC.; FONDAZIONE CENTRO SAN RAFFAELE US Patent					Assay Description Biochemical IC50s were measured at Invitrogen using Z-lyte technology. Briefly, for STK4, the 2×STK4 (MST1)/Ser/Thr 07 mixture was prepared in 50 mM ...				US Patent US10710978 (2020) BindingDB Entry DOI: 10.7270/Q2J67KZW
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase 4 (Homo sapiens (Human))	BDBM451740 (N-(4-(6-amino-5-(1-oxo- 1,2,3,4-tetrahydroisoquino...) Show SMILES COc1cc(NS(=O)(=O)C2CC2)ccc1-c1cnc(N)c(c1)-c1ccc2C(=O)NCCc2c1 Show InChI InChI=1S/C24H24N4O4S/c1-32-22-12-17(28-33(30,31)18-4-5-18)3-7-19(22)16-11-21(23(25)27-13-16)14-2-6-20-15(10-14)8-9-26-24(20)29/h2-3,6-7,10-13,18,28H,4-5,8-9H2,1H3,(H2,25,27)(H,26,29)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<40	n/a	n/a	n/a	n/a	n/a	n/a
DANA-FARBER CANCER INSTITUTE, INC.; FONDAZIONE CENTRO SAN RAFFAELE US Patent					Assay Description Biochemical IC50s were measured at Invitrogen using Z-lyte technology. Briefly, for STK4, the 2×STK4 (MST1)/Ser/Thr 07 mixture was prepared in 50 mM ...				US Patent US10710978 (2020) BindingDB Entry DOI: 10.7270/Q2J67KZW
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase 4 (Homo sapiens (Human))	BDBM451741 (N-(4-(6-amino-5-(1-oxo- 1,2,3,4-tetrahydroisoquino...) Show SMILES Nc1ncc(cc1-c1ccc2C(=O)NCCc2c1)-c1ccc(NS(=O)(=O)C2CC2)cc1F Show InChI InChI=1S/C23H21FN4O3S/c24-21-11-16(28-32(30,31)17-3-4-17)2-6-18(21)15-10-20(22(25)27-12-15)13-1-5-19-14(9-13)7-8-26-23(19)29/h1-2,5-6,9-12,17,28H,3-4,7-8H2,(H2,25,27)(H,26,29)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<40	n/a	n/a	n/a	n/a	n/a	n/a
DANA-FARBER CANCER INSTITUTE, INC.; FONDAZIONE CENTRO SAN RAFFAELE US Patent					Assay Description Biochemical IC50s were measured at Invitrogen using Z-lyte technology. Briefly, for STK4, the 2×STK4 (MST1)/Ser/Thr 07 mixture was prepared in 50 mM ...				US Patent US10710978 (2020) BindingDB Entry DOI: 10.7270/Q2J67KZW
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase 4 (Homo sapiens (Human))	BDBM451747 (6-(2-amino-5-(4- fluorobenzo[d]thiazol-7- yl)pyrid...) Show SMILES Nc1ncc(cc1-c1ccc2C(=O)NCCc2c1)-c1ccc(F)c2ncsc12 Show InChI InChI=1S/C21H15FN4OS/c22-17-4-3-14(19-18(17)26-10-28-19)13-8-16(20(23)25-9-13)11-1-2-15-12(7-11)5-6-24-21(15)27/h1-4,7-10H,5-6H2,(H2,23,25)(H,24,27)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<40	n/a	n/a	n/a	n/a	n/a	n/a
DANA-FARBER CANCER INSTITUTE, INC.; FONDAZIONE CENTRO SAN RAFFAELE US Patent					Assay Description Biochemical IC50s were measured at Invitrogen using Z-lyte technology. Briefly, for STK4, the 2×STK4 (MST1)/Ser/Thr 07 mixture was prepared in 50 mM ...				US Patent US10710978 (2020) BindingDB Entry DOI: 10.7270/Q2J67KZW
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase 4 (Homo sapiens (Human))	BDBM451748 (N-(3-(6-amino-5-(1-oxo- 1,2,3,4-tetrahydroisoquino...) Show SMILES Nc1ncc(cc1-c1ccc2C(=O)NCCc2c1)-c1cccc(NS(=O)(=O)C2CC2)c1 Show InChI InChI=1S/C23H22N4O3S/c24-22-21(15-4-7-20-16(10-15)8-9-25-23(20)28)12-17(13-26-22)14-2-1-3-18(11-14)27-31(29,30)19-5-6-19/h1-4,7,10-13,19,27H,5-6,8-9H2,(H2,24,26)(H,25,28)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<40	n/a	n/a	n/a	n/a	n/a	n/a
DANA-FARBER CANCER INSTITUTE, INC.; FONDAZIONE CENTRO SAN RAFFAELE US Patent					Assay Description Biochemical IC50s were measured at Invitrogen using Z-lyte technology. Briefly, for STK4, the 2×STK4 (MST1)/Ser/Thr 07 mixture was prepared in 50 mM ...				US Patent US10710978 (2020) BindingDB Entry DOI: 10.7270/Q2J67KZW
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase 4 (Homo sapiens (Human))	BDBM451749 (6-(2-amino-5-(3-(thiazol-2- yl)phenyl)pyridin-3-yl...) Show SMILES Nc1ncc(cc1-c1ccc2C(=O)NCCc2c1)-c1cccc(c1)-c1nccs1 Show InChI InChI=1S/C23H18N4OS/c24-21-20(15-4-5-19-16(11-15)6-7-25-22(19)28)12-18(13-27-21)14-2-1-3-17(10-14)23-26-8-9-29-23/h1-5,8-13H,6-7H2,(H2,24,27)(H,25,28)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<40	n/a	n/a	n/a	n/a	n/a	n/a
DANA-FARBER CANCER INSTITUTE, INC.; FONDAZIONE CENTRO SAN RAFFAELE US Patent					Assay Description Biochemical IC50s were measured at Invitrogen using Z-lyte technology. Briefly, for STK4, the 2×STK4 (MST1)/Ser/Thr 07 mixture was prepared in 50 mM ...				US Patent US10710978 (2020) BindingDB Entry DOI: 10.7270/Q2J67KZW
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase 4 (Homo sapiens (Human))	BDBM451751 (4-(6-amino-5-(1-oxo-1,2,3,4- tetrahydroisoquinolin...) Show SMILES COc1cc(ccc1-c1cnc(N)c(c1)-c1ccc2C(=O)NCCc2c1)C#C Show InChI InChI=1S/C23H19N3O2/c1-3-14-4-6-18(21(10-14)28-2)17-12-20(22(24)26-13-17)15-5-7-19-16(11-15)8-9-25-23(19)27/h1,4-7,10-13H,8-9H2,2H3,(H2,24,26)(H,25,27)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<40	n/a	n/a	n/a	n/a	n/a	n/a
DANA-FARBER CANCER INSTITUTE, INC.; FONDAZIONE CENTRO SAN RAFFAELE US Patent					Assay Description Biochemical IC50s were measured at Invitrogen using Z-lyte technology. Briefly, for STK4, the 2×STK4 (MST1)/Ser/Thr 07 mixture was prepared in 50 mM ...				US Patent US10710978 (2020) BindingDB Entry DOI: 10.7270/Q2J67KZW
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase 4 (Homo sapiens (Human))	BDBM451752 (4-(6-amino-5-(2-methyl-1- oxo-1,2,3,4- tetrahydroi...) Show SMILES CN(C1CC1)S(=O)(=O)c1ccc(c(F)c1)-c1cnc(N)c(c1)-c1ccc2C(=O)N(C)CCc2c1 Show InChI InChI=1S/C25H25FN4O3S/c1-29-10-9-16-11-15(3-7-21(16)25(29)31)22-12-17(14-28-24(22)27)20-8-6-19(13-23(20)26)34(32,33)30(2)18-4-5-18/h3,6-8,11-14,18H,4-5,9-10H2,1-2H3,(H2,27,28)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<40	n/a	n/a	n/a	n/a	n/a	n/a
DANA-FARBER CANCER INSTITUTE, INC.; FONDAZIONE CENTRO SAN RAFFAELE US Patent					Assay Description Biochemical IC50s were measured at Invitrogen using Z-lyte technology. Briefly, for STK4, the 2×STK4 (MST1)/Ser/Thr 07 mixture was prepared in 50 mM ...				US Patent US10710978 (2020) BindingDB Entry DOI: 10.7270/Q2J67KZW
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase 4 (Homo sapiens (Human))	BDBM451753 (4-(6-amino-5-(4-oxo-3,4- dihydroquinazolin-7- yl)p...) Show SMILES CN(C1CC1)S(=O)(=O)c1ccc(c(F)c1)-c1cnc(N)c(c1)-c1ccc2c(c1)nc[nH]c2=O Show InChI InChI=1S/C23H20FN5O3S/c1-29(15-3-4-15)33(31,32)16-5-7-17(20(24)10-16)14-8-19(22(25)26-11-14)13-2-6-18-21(9-13)27-12-28-23(18)30/h2,5-12,15H,3-4H2,1H3,(H2,25,26)(H,27,28,30)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<40	n/a	n/a	n/a	n/a	n/a	n/a
DANA-FARBER CANCER INSTITUTE, INC.; FONDAZIONE CENTRO SAN RAFFAELE US Patent					Assay Description Biochemical IC50s were measured at Invitrogen using Z-lyte technology. Briefly, for STK4, the 2×STK4 (MST1)/Ser/Thr 07 mixture was prepared in 50 mM ...				US Patent US10710978 (2020) BindingDB Entry DOI: 10.7270/Q2J67KZW
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase 4 (Homo sapiens (Human))	BDBM451755 (N-(4-(6-amino-5-(1-oxo- 1,2,3,4-tetrahydroisoquino...) Show SMILES Nc1ncc(cc1-c1ccc2C(=O)NCCc2c1)-c1ccc(NS(=O)(=O)C2CC2)cc1OC1CCCCC1 Show InChI InChI=1S/C29H32N4O4S/c30-28-26(18-6-10-25-19(14-18)12-13-31-29(25)34)15-20(17-32-28)24-11-7-21(33-38(35,36)23-8-9-23)16-27(24)37-22-4-2-1-3-5-22/h6-7,10-11,14-17,22-23,33H,1-5,8-9,12-13H2,(H2,30,32)(H,31,34)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<40	n/a	n/a	n/a	n/a	n/a	n/a
DANA-FARBER CANCER INSTITUTE, INC.; FONDAZIONE CENTRO SAN RAFFAELE US Patent					Assay Description Biochemical IC50s were measured at Invitrogen using Z-lyte technology. Briefly, for STK4, the 2×STK4 (MST1)/Ser/Thr 07 mixture was prepared in 50 mM ...				US Patent US10710978 (2020) BindingDB Entry DOI: 10.7270/Q2J67KZW
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase 4 (Homo sapiens (Human))	BDBM451757 (N-(4-(6-amino-5-(1-oxo- 1,2,3,4-tetrahydroisoquino...) Show SMILES CC(C)Oc1cc(NS(=O)(=O)C2CC2)ccc1-c1cnc(N)c(c1)-c1ccc2C(=O)NCCc2c1 Show InChI InChI=1S/C26H28N4O4S/c1-15(2)34-24-13-19(30-35(32,33)20-5-6-20)4-8-21(24)18-12-23(25(27)29-14-18)16-3-7-22-17(11-16)9-10-28-26(22)31/h3-4,7-8,11-15,20,30H,5-6,9-10H2,1-2H3,(H2,27,29)(H,28,31)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<40	n/a	n/a	n/a	n/a	n/a	n/a
DANA-FARBER CANCER INSTITUTE, INC.; FONDAZIONE CENTRO SAN RAFFAELE US Patent					Assay Description Biochemical IC50s were measured at Invitrogen using Z-lyte technology. Briefly, for STK4, the 2×STK4 (MST1)/Ser/Thr 07 mixture was prepared in 50 mM ...				US Patent US10710978 (2020) BindingDB Entry DOI: 10.7270/Q2J67KZW
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase 4 (Homo sapiens (Human))	BDBM451758 (4-(6-amino-5-(1- oxoisoindolin-5-yl)pyridin-3- yl)...) Show SMILES CC(C)Oc1cc(ccc1-c1cnc(N)c(c1)-c1ccc2C(=O)NCc2c1)S(=O)(=O)N(C)C1CC1 Show InChI InChI=1S/C26H28N4O4S/c1-15(2)34-24-12-20(35(32,33)30(3)19-5-6-19)7-9-21(24)18-11-23(25(27)28-13-18)16-4-8-22-17(10-16)14-29-26(22)31/h4,7-13,15,19H,5-6,14H2,1-3H3,(H2,27,28)(H,29,31)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<40	n/a	n/a	n/a	n/a	n/a	n/a
DANA-FARBER CANCER INSTITUTE, INC.; FONDAZIONE CENTRO SAN RAFFAELE US Patent					Assay Description Biochemical IC50s were measured at Invitrogen using Z-lyte technology. Briefly, for STK4, the 2×STK4 (MST1)/Ser/Thr 07 mixture was prepared in 50 mM ...				US Patent US10710978 (2020) BindingDB Entry DOI: 10.7270/Q2J67KZW
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase 4 (Homo sapiens (Human))	BDBM451759 (N-(4-(6-amino-5-(1-oxo- 1,2,3,4-tetrahydroisoquino...) Show SMILES Nc1ncc(cc1-c1ccc2C(=O)NCCc2c1)-c1ccc(NS(=O)(=O)C2CC2)cc1OC1CCCC1 Show InChI InChI=1S/C28H30N4O4S/c29-27-25(17-5-9-24-18(13-17)11-12-30-28(24)33)14-19(16-31-27)23-10-6-20(32-37(34,35)22-7-8-22)15-26(23)36-21-3-1-2-4-21/h5-6,9-10,13-16,21-22,32H,1-4,7-8,11-12H2,(H2,29,31)(H,30,33)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<40	n/a	n/a	n/a	n/a	n/a	n/a
DANA-FARBER CANCER INSTITUTE, INC.; FONDAZIONE CENTRO SAN RAFFAELE US Patent					Assay Description Biochemical IC50s were measured at Invitrogen using Z-lyte technology. Briefly, for STK4, the 2×STK4 (MST1)/Ser/Thr 07 mixture was prepared in 50 mM ...				US Patent US10710978 (2020) BindingDB Entry DOI: 10.7270/Q2J67KZW
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase 4 (Homo sapiens (Human))	BDBM451761 (4-(6-amino-5-(1- oxoisoindolin-5-yl)pyridin-3- yl)...) Show SMILES CN(C1CC1)S(=O)(=O)c1ccc(c(F)c1)-c1cnc(N)c(c1)-c1ccc2C(=O)NCc2c1 Show InChI InChI=1S/C23H21FN4O3S/c1-28(16-3-4-16)32(30,31)17-5-7-18(21(24)10-17)15-9-20(22(25)26-11-15)13-2-6-19-14(8-13)12-27-23(19)29/h2,5-11,16H,3-4,12H2,1H3,(H2,25,26)(H,27,29)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<40	n/a	n/a	n/a	n/a	n/a	n/a
DANA-FARBER CANCER INSTITUTE, INC.; FONDAZIONE CENTRO SAN RAFFAELE US Patent					Assay Description Biochemical IC50s were measured at Invitrogen using Z-lyte technology. Briefly, for STK4, the 2×STK4 (MST1)/Ser/Thr 07 mixture was prepared in 50 mM ...				US Patent US10710978 (2020) BindingDB Entry DOI: 10.7270/Q2J67KZW
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase 3 (Homo sapiens (Human))	BDBM451761 (4-(6-amino-5-(1- oxoisoindolin-5-yl)pyridin-3- yl)...) Show SMILES CN(C1CC1)S(=O)(=O)c1ccc(c(F)c1)-c1cnc(N)c(c1)-c1ccc2C(=O)NCc2c1 Show InChI InChI=1S/C23H21FN4O3S/c1-28(16-3-4-16)32(30,31)17-5-7-18(21(24)10-17)15-9-20(22(25)26-11-15)13-2-6-19-14(8-13)12-27-23(19)29/h2,5-11,16H,3-4,12H2,1H3,(H2,25,26)(H,27,29)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<40	n/a	n/a	n/a	n/a	n/a	n/a
DANA-FARBER CANCER INSTITUTE, INC.; FONDAZIONE CENTRO SAN RAFFAELE US Patent					Assay Description Biochemical IC50s were measured at Invitrogen using Z-lyte technology. Briefly, for STK4, the 2×STK4 (MST1)/Ser/Thr 07 mixture was prepared in 50 mM ...				US Patent US10710978 (2020) BindingDB Entry DOI: 10.7270/Q2J67KZW
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase 4 (Homo sapiens (Human))	BDBM451763 (6-(2-amino-5-(4- chlorothiazol-5-yl)pyridin-3- yl)...) Show SMILES Nc1ncc(cc1-c1ccc2C(=O)NCCc2c1)-c1scnc1Cl Show InChI InChI=1S/C17H13ClN4OS/c18-15-14(24-8-22-15)11-6-13(16(19)21-7-11)9-1-2-12-10(5-9)3-4-20-17(12)23/h1-2,5-8H,3-4H2,(H2,19,21)(H,20,23)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<40	n/a	n/a	n/a	n/a	n/a	n/a
DANA-FARBER CANCER INSTITUTE, INC.; FONDAZIONE CENTRO SAN RAFFAELE US Patent					Assay Description Biochemical IC50s were measured at Invitrogen using Z-lyte technology. Briefly, for STK4, the 2×STK4 (MST1)/Ser/Thr 07 mixture was prepared in 50 mM ...				US Patent US10710978 (2020) BindingDB Entry DOI: 10.7270/Q2J67KZW
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase 4 (Homo sapiens (Human))	BDBM451766 (4-(6-amino-5-(1-oxo-1,2,3,4- tetrahydroisoquinolin...) Show SMILES COc1cc(ccc1-c1cnc(N)c(c1)-c1ccc2C(=O)NCCc2c1)S(=O)(=O)N(C)C1CC1 Show InChI InChI=1S/C25H26N4O4S/c1-29(18-4-5-18)34(31,32)19-6-8-20(23(13-19)33-2)17-12-22(24(26)28-14-17)15-3-7-21-16(11-15)9-10-27-25(21)30/h3,6-8,11-14,18H,4-5,9-10H2,1-2H3,(H2,26,28)(H,27,30)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<40	n/a	n/a	n/a	n/a	n/a	n/a
DANA-FARBER CANCER INSTITUTE, INC.; FONDAZIONE CENTRO SAN RAFFAELE US Patent					Assay Description Biochemical IC50s were measured at Invitrogen using Z-lyte technology. Briefly, for STK4, the 2×STK4 (MST1)/Ser/Thr 07 mixture was prepared in 50 mM ...				US Patent US10710978 (2020) BindingDB Entry DOI: 10.7270/Q2J67KZW
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase 3 (Homo sapiens (Human))	BDBM451766 (4-(6-amino-5-(1-oxo-1,2,3,4- tetrahydroisoquinolin...) Show SMILES COc1cc(ccc1-c1cnc(N)c(c1)-c1ccc2C(=O)NCCc2c1)S(=O)(=O)N(C)C1CC1 Show InChI InChI=1S/C25H26N4O4S/c1-29(18-4-5-18)34(31,32)19-6-8-20(23(13-19)33-2)17-12-22(24(26)28-14-17)15-3-7-21-16(11-15)9-10-27-25(21)30/h3,6-8,11-14,18H,4-5,9-10H2,1-2H3,(H2,26,28)(H,27,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<40	n/a	n/a	n/a	n/a	n/a	n/a
DANA-FARBER CANCER INSTITUTE, INC.; FONDAZIONE CENTRO SAN RAFFAELE US Patent					Assay Description Biochemical IC50s were measured at Invitrogen using Z-lyte technology. Briefly, for STK4, the 2×STK4 (MST1)/Ser/Thr 07 mixture was prepared in 50 mM ...				US Patent US10710978 (2020) BindingDB Entry DOI: 10.7270/Q2J67KZW
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase 4 (Homo sapiens (Human))	BDBM451712 (6-(2-amino-5-(3- nitrophenyl)pyridin-3-yl)-3,4- di...) Show SMILES Nc1ncc(cc1-c1ccc2C(=O)NCCc2c1)-c1cccc(c1)[N+]([O-])=O Show InChI InChI=1S/C20H16N4O3/c21-19-18(13-4-5-17-14(8-13)6-7-22-20(17)25)10-15(11-23-19)12-2-1-3-16(9-12)24(26)27/h1-5,8-11H,6-7H2,(H2,21,23)(H,22,25)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<40	n/a	n/a	n/a	n/a	n/a	n/a
DANA-FARBER CANCER INSTITUTE, INC.; FONDAZIONE CENTRO SAN RAFFAELE US Patent					Assay Description Biochemical IC50s were measured at Invitrogen using Z-lyte technology. Briefly, for STK4, the 2×STK4 (MST1)/Ser/Thr 07 mixture was prepared in 50 mM ...				US Patent US10710978 (2020) BindingDB Entry DOI: 10.7270/Q2J67KZW
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase 4 (Homo sapiens (Human))	BDBM451744 (6-(2-amino-5-(2-fluoro-4- nitrophenyl)pyridin-3-yl...) Show SMILES Nc1ncc(cc1-c1ccc2C(=O)NCCc2c1)-c1ccc(cc1F)[N+]([O-])=O Show InChI InChI=1S/C20H15FN4O3/c21-18-9-14(25(27)28)2-4-15(18)13-8-17(19(22)24-10-13)11-1-3-16-12(7-11)5-6-23-20(16)26/h1-4,7-10H,5-6H2,(H2,22,24)(H,23,26)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	120	n/a	n/a	n/a	n/a	n/a	n/a
DANA-FARBER CANCER INSTITUTE, INC.; FONDAZIONE CENTRO SAN RAFFAELE US Patent					Assay Description Biochemical IC50s were measured at Invitrogen using Z-lyte technology. Briefly, for STK4, the 2×STK4 (MST1)/Ser/Thr 07 mixture was prepared in 50 mM ...				US Patent US10710978 (2020) BindingDB Entry DOI: 10.7270/Q2J67KZW
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase 4 (Homo sapiens (Human))	BDBM451735 (6-(2-amino-5-(4-ethynyl-2- fluoro-5-nitrophenyl)py...) Show SMILES Nc1ncc(cc1-c1ccc2C(=O)NCCc2c1)-c1cc(c(cc1F)C#C)[N+]([O-])=O Show InChI InChI=1S/C22H15FN4O3/c1-2-12-9-19(23)17(10-20(12)27(29)30)15-8-18(21(24)26-11-15)13-3-4-16-14(7-13)5-6-25-22(16)28/h1,3-4,7-11H,5-6H2,(H2,24,26)(H,25,28)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	120	n/a	n/a	n/a	n/a	n/a	n/a
DANA-FARBER CANCER INSTITUTE, INC.; FONDAZIONE CENTRO SAN RAFFAELE US Patent					Assay Description Biochemical IC50s were measured at Invitrogen using Z-lyte technology. Briefly, for STK4, the 2×STK4 (MST1)/Ser/Thr 07 mixture was prepared in 50 mM ...				US Patent US10710978 (2020) BindingDB Entry DOI: 10.7270/Q2J67KZW
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase 4 (Homo sapiens (Human))	BDBM451742 (4-(6-amino-5-(1-oxo-1,2,3,4- tetrahydroisoquinolin...) Show SMILES COc1cc(ccc1-c1cnc(N)c(c1)-c1ccc2C(=O)NCCc2c1)S(=O)(=O)N(C)C1CCCCC1 Show InChI InChI=1S/C28H32N4O4S/c1-32(21-6-4-3-5-7-21)37(34,35)22-9-11-23(26(16-22)36-2)20-15-25(27(29)31-17-20)18-8-10-24-19(14-18)12-13-30-28(24)33/h8-11,14-17,21H,3-7,12-13H2,1-2H3,(H2,29,31)(H,30,33)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	120	n/a	n/a	n/a	n/a	n/a	n/a
DANA-FARBER CANCER INSTITUTE, INC.; FONDAZIONE CENTRO SAN RAFFAELE US Patent					Assay Description Biochemical IC50s were measured at Invitrogen using Z-lyte technology. Briefly, for STK4, the 2×STK4 (MST1)/Ser/Thr 07 mixture was prepared in 50 mM ...				US Patent US10710978 (2020) BindingDB Entry DOI: 10.7270/Q2J67KZW
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase 24 (Homo sapiens (Human))	BDBM451741 (N-(4-(6-amino-5-(1-oxo- 1,2,3,4-tetrahydroisoquino...) Show SMILES Nc1ncc(cc1-c1ccc2C(=O)NCCc2c1)-c1ccc(NS(=O)(=O)C2CC2)cc1F Show InChI InChI=1S/C23H21FN4O3S/c24-21-11-16(28-32(30,31)17-3-4-17)2-6-18(21)15-10-20(22(25)27-12-15)13-1-5-19-14(9-13)7-8-26-23(19)29/h1-2,5-6,9-12,17,28H,3-4,7-8H2,(H2,25,27)(H,26,29)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	120	n/a	n/a	n/a	n/a	n/a	n/a
DANA-FARBER CANCER INSTITUTE, INC.; FONDAZIONE CENTRO SAN RAFFAELE US Patent					Assay Description Biochemical IC50s were measured at Invitrogen using Z-lyte technology. Briefly, for STK4, the 2×STK4 (MST1)/Ser/Thr 07 mixture was prepared in 50 mM ...				US Patent US10710978 (2020) BindingDB Entry DOI: 10.7270/Q2J67KZW
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase 4 (Homo sapiens (Human))	BDBM451713 (6-(2-amino-5-(2- fluorophenyl)pyridin-3-yl)- 3,4-d...) Show SMILES Nc1ncc(cc1-c1ccc2C(=O)NCCc2c1)-c1ccccc1F Show InChI InChI=1S/C20H16FN3O/c21-18-4-2-1-3-15(18)14-10-17(19(22)24-11-14)12-5-6-16-13(9-12)7-8-23-20(16)25/h1-6,9-11H,7-8H2,(H2,22,24)(H,23,25)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	120	n/a	n/a	n/a	n/a	n/a	n/a
DANA-FARBER CANCER INSTITUTE, INC.; FONDAZIONE CENTRO SAN RAFFAELE US Patent					Assay Description Biochemical IC50s were measured at Invitrogen using Z-lyte technology. Briefly, for STK4, the 2×STK4 (MST1)/Ser/Thr 07 mixture was prepared in 50 mM ...				US Patent US10710978 (2020) BindingDB Entry DOI: 10.7270/Q2J67KZW
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase 4 (Homo sapiens (Human))	BDBM451767 (6-(2-amino-5-(5- fluorobenzo[d]thiazol-6- yl)pyrid...) Show SMILES Nc1ncc(cc1-c1ccc2C(=O)NCCc2c1)-c1cc2scnc2cc1F Show InChI InChI=1S/C21H15FN4OS/c22-17-8-18-19(28-10-26-18)7-15(17)13-6-16(20(23)25-9-13)11-1-2-14-12(5-11)3-4-24-21(14)27/h1-2,5-10H,3-4H2,(H2,23,25)(H,24,27)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	120	n/a	n/a	n/a	n/a	n/a	n/a
DANA-FARBER CANCER INSTITUTE, INC.; FONDAZIONE CENTRO SAN RAFFAELE US Patent					Assay Description Biochemical IC50s were measured at Invitrogen using Z-lyte technology. Briefly, for STK4, the 2×STK4 (MST1)/Ser/Thr 07 mixture was prepared in 50 mM ...				US Patent US10710978 (2020) BindingDB Entry DOI: 10.7270/Q2J67KZW
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase 24 (Homo sapiens (Human))	BDBM451766 (4-(6-amino-5-(1-oxo-1,2,3,4- tetrahydroisoquinolin...) Show SMILES COc1cc(ccc1-c1cnc(N)c(c1)-c1ccc2C(=O)NCCc2c1)S(=O)(=O)N(C)C1CC1 Show InChI InChI=1S/C25H26N4O4S/c1-29(18-4-5-18)34(31,32)19-6-8-20(23(13-19)33-2)17-12-22(24(26)28-14-17)15-3-7-21-16(11-15)9-10-27-25(21)30/h3,6-8,11-14,18H,4-5,9-10H2,1-2H3,(H2,26,28)(H,27,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	120	n/a	n/a	n/a	n/a	n/a	n/a
DANA-FARBER CANCER INSTITUTE, INC.; FONDAZIONE CENTRO SAN RAFFAELE US Patent					Assay Description Biochemical IC50s were measured at Invitrogen using Z-lyte technology. Briefly, for STK4, the 2×STK4 (MST1)/Ser/Thr 07 mixture was prepared in 50 mM ...				US Patent US10710978 (2020) BindingDB Entry DOI: 10.7270/Q2J67KZW
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase 4 (Homo sapiens (Human))	BDBM451764 (6-(2-amino-5-(4- chlorothiazol-5-yl)pyridin-3- yl)...) Show SMILES CN1CCc2cc(ccc2C1=O)-c1cc(cnc1N)-c1cccc2ncsc12 Show InChI InChI=1S/C22H18N4OS/c1-26-8-7-14-9-13(5-6-17(14)22(26)27)18-10-15(11-24-21(18)23)16-3-2-4-19-20(16)28-12-25-19/h2-6,9-12H,7-8H2,1H3,(H2,23,24)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	120	n/a	n/a	n/a	n/a	n/a	n/a
DANA-FARBER CANCER INSTITUTE, INC.; FONDAZIONE CENTRO SAN RAFFAELE US Patent					Assay Description Biochemical IC50s were measured at Invitrogen using Z-lyte technology. Briefly, for STK4, the 2×STK4 (MST1)/Ser/Thr 07 mixture was prepared in 50 mM ...				US Patent US10710978 (2020) BindingDB Entry DOI: 10.7270/Q2J67KZW
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase 3 (Homo sapiens (Human))	BDBM451711 (6-(2-amino-5-(2-fluoro-5- nitrophenyl)pyridin-3-yl...) Show SMILES Nc1ncc(cc1-c1ccc2C(=O)NCCc2c1)-c1cc(ccc1F)[N+]([O-])=O Show InChI InChI=1S/C20H15FN4O3/c21-18-4-2-14(25(27)28)9-16(18)13-8-17(19(22)24-10-13)11-1-3-15-12(7-11)5-6-23-20(15)26/h1-4,7-10H,5-6H2,(H2,22,24)(H,23,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	120	n/a	n/a	n/a	n/a	n/a	n/a
DANA-FARBER CANCER INSTITUTE, INC.; FONDAZIONE CENTRO SAN RAFFAELE US Patent					Assay Description Biochemical IC50s were measured at Invitrogen using Z-lyte technology. Briefly, for STK4, the 2×STK4 (MST1)/Ser/Thr 07 mixture was prepared in 50 mM ...				US Patent US10710978 (2020) BindingDB Entry DOI: 10.7270/Q2J67KZW
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase 3 (Homo sapiens (Human))	BDBM451763 (6-(2-amino-5-(4- chlorothiazol-5-yl)pyridin-3- yl)...) Show SMILES Nc1ncc(cc1-c1ccc2C(=O)NCCc2c1)-c1scnc1Cl Show InChI InChI=1S/C17H13ClN4OS/c18-15-14(24-8-22-15)11-6-13(16(19)21-7-11)9-1-2-12-10(5-9)3-4-20-17(12)23/h1-2,5-8H,3-4H2,(H2,19,21)(H,20,23)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	120	n/a	n/a	n/a	n/a	n/a	n/a
DANA-FARBER CANCER INSTITUTE, INC.; FONDAZIONE CENTRO SAN RAFFAELE US Patent					Assay Description Biochemical IC50s were measured at Invitrogen using Z-lyte technology. Briefly, for STK4, the 2×STK4 (MST1)/Ser/Thr 07 mixture was prepared in 50 mM ...				US Patent US10710978 (2020) BindingDB Entry DOI: 10.7270/Q2J67KZW
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase 3 (Homo sapiens (Human))	BDBM451762 (3-(6-amino-5-(1-oxo-1,2,3,4- tetrahydroisoquinolin...) Show SMILES Nc1ncc(cc1-c1ccc2C(=O)NCCc2c1)-c1cccc(c1)C#N Show InChI InChI=1S/C21H16N4O/c22-11-13-2-1-3-14(8-13)17-10-19(20(23)25-12-17)15-4-5-18-16(9-15)6-7-24-21(18)26/h1-5,8-10,12H,6-7H2,(H2,23,25)(H,24,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	120	n/a	n/a	n/a	n/a	n/a	n/a
DANA-FARBER CANCER INSTITUTE, INC.; FONDAZIONE CENTRO SAN RAFFAELE US Patent					Assay Description Biochemical IC50s were measured at Invitrogen using Z-lyte technology. Briefly, for STK4, the 2×STK4 (MST1)/Ser/Thr 07 mixture was prepared in 50 mM ...				US Patent US10710978 (2020) BindingDB Entry DOI: 10.7270/Q2J67KZW
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase 4 (Homo sapiens (Human))	BDBM451762 (3-(6-amino-5-(1-oxo-1,2,3,4- tetrahydroisoquinolin...) Show SMILES Nc1ncc(cc1-c1ccc2C(=O)NCCc2c1)-c1cccc(c1)C#N Show InChI InChI=1S/C21H16N4O/c22-11-13-2-1-3-14(8-13)17-10-19(20(23)25-12-17)15-4-5-18-16(9-15)6-7-24-21(18)26/h1-5,8-10,12H,6-7H2,(H2,23,25)(H,24,26)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	120	n/a	n/a	n/a	n/a	n/a	n/a
DANA-FARBER CANCER INSTITUTE, INC.; FONDAZIONE CENTRO SAN RAFFAELE US Patent					Assay Description Biochemical IC50s were measured at Invitrogen using Z-lyte technology. Briefly, for STK4, the 2×STK4 (MST1)/Ser/Thr 07 mixture was prepared in 50 mM ...				US Patent US10710978 (2020) BindingDB Entry DOI: 10.7270/Q2J67KZW
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase 4 (Homo sapiens (Human))	BDBM451760 (5-(2-amino-5-(4- fluorobenzo[d]thiazol-7- yl)pyrid...) Show SMILES Nc1ncc(cc1-c1ccc2C(=O)NCc2c1)-c1ccc(F)c2ncsc12 Show InChI InChI=1S/C20H13FN4OS/c21-16-4-3-13(18-17(16)25-9-27-18)12-6-15(19(22)23-7-12)10-1-2-14-11(5-10)8-24-20(14)26/h1-7,9H,8H2,(H2,22,23)(H,24,26)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	120	n/a	n/a	n/a	n/a	n/a	n/a
DANA-FARBER CANCER INSTITUTE, INC.; FONDAZIONE CENTRO SAN RAFFAELE US Patent					Assay Description Biochemical IC50s were measured at Invitrogen using Z-lyte technology. Briefly, for STK4, the 2×STK4 (MST1)/Ser/Thr 07 mixture was prepared in 50 mM ...				US Patent US10710978 (2020) BindingDB Entry DOI: 10.7270/Q2J67KZW
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase 4 (Homo sapiens (Human))	BDBM451756 (N-(4-(6-amino-5-(1-oxo- 1,2,3,4-tetrahydroisoquino...) Show SMILES Nc1ncc(cc1-c1ccc2C(=O)NCCc2c1)-c1ccc(NS(=O)(=O)C2CC2)cc1OCc1ccccc1 Show InChI InChI=1S/C30H28N4O4S/c31-29-27(20-6-10-26-21(14-20)12-13-32-30(26)35)15-22(17-33-29)25-11-7-23(34-39(36,37)24-8-9-24)16-28(25)38-18-19-4-2-1-3-5-19/h1-7,10-11,14-17,24,34H,8-9,12-13,18H2,(H2,31,33)(H,32,35)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	120	n/a	n/a	n/a	n/a	n/a	n/a
DANA-FARBER CANCER INSTITUTE, INC.; FONDAZIONE CENTRO SAN RAFFAELE US Patent					Assay Description Biochemical IC50s were measured at Invitrogen using Z-lyte technology. Briefly, for STK4, the 2×STK4 (MST1)/Ser/Thr 07 mixture was prepared in 50 mM ...				US Patent US10710978 (2020) BindingDB Entry DOI: 10.7270/Q2J67KZW
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase 4 (Homo sapiens (Human))	BDBM451754 (7-(2-amino-5- (benzo[d]thiazol-7-yl)pyridin- 3-yl)...) Show SMILES Nc1ncc(cc1-c1ccc2c(c1)nc[nH]c2=O)-c1cccc2ncsc12 Show InChI InChI=1S/C20H13N5OS/c21-19-15(11-4-5-14-17(7-11)23-9-24-20(14)26)6-12(8-22-19)13-2-1-3-16-18(13)27-10-25-16/h1-10H,(H2,21,22)(H,23,24,26)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	120	n/a	n/a	n/a	n/a	n/a	n/a
DANA-FARBER CANCER INSTITUTE, INC.; FONDAZIONE CENTRO SAN RAFFAELE US Patent					Assay Description Biochemical IC50s were measured at Invitrogen using Z-lyte technology. Briefly, for STK4, the 2×STK4 (MST1)/Ser/Thr 07 mixture was prepared in 50 mM ...				US Patent US10710978 (2020) BindingDB Entry DOI: 10.7270/Q2J67KZW
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase 4 (Homo sapiens (Human))	BDBM451750 (6-(2-amino-5-(2-methoxy-4- (thiazol-2-yl)phenyl)py...) Show SMILES COc1cc(ccc1-c1cnc(N)c(c1)-c1ccc2C(=O)NCCc2c1)-c1nccs1 Show InChI InChI=1S/C24H20N4O2S/c1-30-21-12-16(24-27-8-9-31-24)3-4-18(21)17-11-20(22(25)28-13-17)14-2-5-19-15(10-14)6-7-26-23(19)29/h2-5,8-13H,6-7H2,1H3,(H2,25,28)(H,26,29)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	120	n/a	n/a	n/a	n/a	n/a	n/a
DANA-FARBER CANCER INSTITUTE, INC.; FONDAZIONE CENTRO SAN RAFFAELE US Patent					Assay Description Biochemical IC50s were measured at Invitrogen using Z-lyte technology. Briefly, for STK4, the 2×STK4 (MST1)/Ser/Thr 07 mixture was prepared in 50 mM ...				US Patent US10710978 (2020) BindingDB Entry DOI: 10.7270/Q2J67KZW
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase 4 (Homo sapiens (Human))	BDBM451721 (3-(6-amino-5-(1-oxo-1,2,3,4- tetrahydroisoquinolin...) Show SMILES Nc1ncc(cc1-c1ccc2C(=O)NCCc2c1)-c1cccc(c1)S(=O)(=O)NC1CC1 Show InChI InChI=1S/C23H22N4O3S/c24-22-21(15-4-7-20-16(10-15)8-9-25-23(20)28)12-17(13-26-22)14-2-1-3-19(11-14)31(29,30)27-18-5-6-18/h1-4,7,10-13,18,27H,5-6,8-9H2,(H2,24,26)(H,25,28)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	120	n/a	n/a	n/a	n/a	n/a	n/a
DANA-FARBER CANCER INSTITUTE, INC.; FONDAZIONE CENTRO SAN RAFFAELE US Patent					Assay Description Biochemical IC50s were measured at Invitrogen using Z-lyte technology. Briefly, for STK4, the 2×STK4 (MST1)/Ser/Thr 07 mixture was prepared in 50 mM ...				US Patent US10710978 (2020) BindingDB Entry DOI: 10.7270/Q2J67KZW
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase 3 (Homo sapiens (Human))	BDBM451721 (3-(6-amino-5-(1-oxo-1,2,3,4- tetrahydroisoquinolin...) Show SMILES Nc1ncc(cc1-c1ccc2C(=O)NCCc2c1)-c1cccc(c1)S(=O)(=O)NC1CC1 Show InChI InChI=1S/C23H22N4O3S/c24-22-21(15-4-7-20-16(10-15)8-9-25-23(20)28)12-17(13-26-22)14-2-1-3-19(11-14)31(29,30)27-18-5-6-18/h1-4,7,10-13,18,27H,5-6,8-9H2,(H2,24,26)(H,25,28)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	120	n/a	n/a	n/a	n/a	n/a	n/a
DANA-FARBER CANCER INSTITUTE, INC.; FONDAZIONE CENTRO SAN RAFFAELE US Patent					Assay Description Biochemical IC50s were measured at Invitrogen using Z-lyte technology. Briefly, for STK4, the 2×STK4 (MST1)/Ser/Thr 07 mixture was prepared in 50 mM ...				US Patent US10710978 (2020) BindingDB Entry DOI: 10.7270/Q2J67KZW
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase 4 (Homo sapiens (Human))	BDBM451763 (6-(2-amino-5-(4- chlorothiazol-5-yl)pyridin-3- yl)...) Show SMILES Nc1ncc(cc1-c1ccc2C(=O)NCCc2c1)-c1scnc1Cl Show InChI InChI=1S/C17H13ClN4OS/c18-15-14(24-8-22-15)11-6-13(16(19)21-7-11)9-1-2-12-10(5-9)3-4-20-17(12)23/h1-2,5-8H,3-4H2,(H2,19,21)(H,20,23)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	120	n/a	n/a	n/a	n/a	n/a	n/a
DANA-FARBER CANCER INSTITUTE, INC.; FONDAZIONE CENTRO SAN RAFFAELE US Patent					Assay Description Biochemical IC50s were measured at Invitrogen using Z-lyte technology. Briefly, for STK4, the 2×STK4 (MST1)/Ser/Thr 07 mixture was prepared in 50 mM ...				US Patent US10710978 (2020) BindingDB Entry DOI: 10.7270/Q2J67KZW
					More data for this Ligand-Target Pair

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