Compile Data Set for Download or QSAR

Found 66 hits Enz. Inhib. hit(s) with all data for assayid = 1 entry = 1919   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human))	BDBM15165 (1-[1-({4-[3-phenyl-7-(2H-1,2,3,4-tetrazol-5-yl)qui...) Show SMILES O=c1[nH]c2ccccc2n1C1CCN(Cc2ccc(cc2)-c2nc3cc(ccc3nc2-c2ccccc2)-c2nnn[nH]2)CC1 Show InChI InChI=1S/C34H29N9O/c44-34-37-28-8-4-5-9-30(28)43(34)26-16-18-42(19-17-26)21-22-10-12-24(13-11-22)32-31(23-6-2-1-3-7-23)35-27-15-14-25(20-29(27)36-32)33-38-40-41-39-33/h1-15,20,26H,16-19,21H2,(H,37,44)(H,38,39,40,41)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	20	n/a	n/a	n/a	n/a	7.5	22
Merck Research Laboratories					Assay Description Purified recombinant human Akt1, Akt2, and Akt3 proteins were monitored for kinase activity in the presence or absence of Akt inhibitors in a 96-well...				Bioorg Med Chem Lett 15: 761-4 (2005) Article DOI: 10.1016/j.bmcl.2004.11.011 BindingDB Entry DOI: 10.7270/Q2TX3CM4
					More data for this Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human))	BDBM15167 (1-[1-({4-[7-(2-methyl-2H-1,2,3,4-tetrazol-5-yl)-3-...) Show SMILES Cn1nnc(n1)-c1ccc2nc(-c3ccccc3)c(nc2c1)-c1ccc(CN2CCC(CC2)n2c3ccccc3[nH]c2=O)cc1 Show InChI InChI=1S/C35H31N9O/c1-42-40-34(39-41-42)26-15-16-28-30(21-26)37-33(32(36-28)24-7-3-2-4-8-24)25-13-11-23(12-14-25)22-43-19-17-27(18-20-43)44-31-10-6-5-9-29(31)38-35(44)45/h2-16,21,27H,17-20,22H2,1H3,(H,38,45)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	55	n/a	n/a	n/a	n/a	7.5	22
Merck Research Laboratories					Assay Description Purified recombinant human Akt1, Akt2, and Akt3 proteins were monitored for kinase activity in the presence or absence of Akt inhibitors in a 96-well...				Bioorg Med Chem Lett 15: 761-4 (2005) Article DOI: 10.1016/j.bmcl.2004.11.011 BindingDB Entry DOI: 10.7270/Q2TX3CM4
					More data for this Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human))	BDBM15169 (1-{1-[(4-{7-phenyl-1H-imidazo[4,5-g]quinoxalin-6-y...) Show SMILES O=c1[nH]c2ccccc2n1C1CCN(Cc2ccc(cc2)-c2nc3cc4[nH]cnc4cc3nc2-c2ccccc2)CC1 Show InChI InChI=1S/C34H29N7O/c42-34-39-26-8-4-5-9-31(26)41(34)25-14-16-40(17-15-25)20-22-10-12-24(13-11-22)33-32(23-6-2-1-3-7-23)37-29-18-27-28(36-21-35-27)19-30(29)38-33/h1-13,18-19,21,25H,14-17,20H2,(H,35,36)(H,39,42)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase MCE MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	58	n/a	n/a	n/a	n/a	7.5	22
Merck Research Laboratories					Assay Description Purified recombinant human Akt1, Akt2, and Akt3 proteins were monitored for kinase activity in the presence or absence of Akt inhibitors in a 96-well...				Bioorg Med Chem Lett 15: 761-4 (2005) Article DOI: 10.1016/j.bmcl.2004.11.011 BindingDB Entry DOI: 10.7270/Q2TX3CM4
					More data for this Ligand-Target Pair				3D Structure (crystal)
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human))	BDBM15164 (1-[1-({4-[3-phenyl-6-(2H-1,2,3,4-tetrazol-5-yl)qui...) Show SMILES O=c1[nH]c2ccccc2n1C1CCN(Cc2ccc(cc2)-c2nc3ccc(cc3nc2-c2ccccc2)-c2nnn[nH]2)CC1 Show InChI InChI=1S/C34H29N9O/c44-34-37-28-8-4-5-9-30(28)43(34)26-16-18-42(19-17-26)21-22-10-12-24(13-11-22)32-31(23-6-2-1-3-7-23)36-29-20-25(14-15-27(29)35-32)33-38-40-41-39-33/h1-15,20,26H,16-19,21H2,(H,37,44)(H,38,39,40,41)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	63	n/a	n/a	n/a	n/a	7.5	22
Merck Research Laboratories					Assay Description Purified recombinant human Akt1, Akt2, and Akt3 proteins were monitored for kinase activity in the presence or absence of Akt inhibitors in a 96-well...				Bioorg Med Chem Lett 15: 761-4 (2005) Article DOI: 10.1016/j.bmcl.2004.11.011 BindingDB Entry DOI: 10.7270/Q2TX3CM4
					More data for this Ligand-Target Pair
RAC-beta serine/threonine-protein kinase (Homo sapiens (Human))	BDBM15164 (1-[1-({4-[3-phenyl-6-(2H-1,2,3,4-tetrazol-5-yl)qui...) Show SMILES O=c1[nH]c2ccccc2n1C1CCN(Cc2ccc(cc2)-c2nc3ccc(cc3nc2-c2ccccc2)-c2nnn[nH]2)CC1 Show InChI InChI=1S/C34H29N9O/c44-34-37-28-8-4-5-9-30(28)43(34)26-16-18-42(19-17-26)21-22-10-12-24(13-11-22)32-31(23-6-2-1-3-7-23)36-29-20-25(14-15-27(29)35-32)33-38-40-41-39-33/h1-15,20,26H,16-19,21H2,(H,37,44)(H,38,39,40,41)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	65	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories					Assay Description Purified recombinant human Akt1, Akt2, and Akt3 proteins were monitored for kinase activity in the presence or absence of Akt inhibitors in a 96-well...				Bioorg Med Chem Lett 15: 761-4 (2005) Article DOI: 10.1016/j.bmcl.2004.11.011 BindingDB Entry DOI: 10.7270/Q2TX3CM4
					More data for this Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human))	BDBM15168 (1-{1-[(4-{7-phenyl-1H-pyrazolo[3,4-g]quinoxalin-6-...) Show SMILES O=c1[nH]c2ccccc2n1C1CCN(Cc2ccc(cc2)-c2nc3cc4cn[nH]c4cc3nc2-c2ccccc2)CC1 Show InChI InChI=1S/C34H29N7O/c42-34-38-27-8-4-5-9-31(27)41(34)26-14-16-40(17-15-26)21-22-10-12-24(13-11-22)33-32(23-6-2-1-3-7-23)37-30-19-28-25(20-35-39-28)18-29(30)36-33/h1-13,18-20,26H,14-17,21H2,(H,35,39)(H,38,42)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	85	n/a	n/a	n/a	n/a	7.5	22
Merck Research Laboratories					Assay Description Purified recombinant human Akt1, Akt2, and Akt3 proteins were monitored for kinase activity in the presence or absence of Akt inhibitors in a 96-well...				Bioorg Med Chem Lett 15: 761-4 (2005) Article DOI: 10.1016/j.bmcl.2004.11.011 BindingDB Entry DOI: 10.7270/Q2TX3CM4
					More data for this Ligand-Target Pair
RAC-beta serine/threonine-protein kinase (Homo sapiens (Human))	BDBM15165 (1-[1-({4-[3-phenyl-7-(2H-1,2,3,4-tetrazol-5-yl)qui...) Show SMILES O=c1[nH]c2ccccc2n1C1CCN(Cc2ccc(cc2)-c2nc3cc(ccc3nc2-c2ccccc2)-c2nnn[nH]2)CC1 Show InChI InChI=1S/C34H29N9O/c44-34-37-28-8-4-5-9-30(28)43(34)26-16-18-42(19-17-26)21-22-10-12-24(13-11-22)32-31(23-6-2-1-3-7-23)35-27-15-14-25(20-29(27)36-32)33-38-40-41-39-33/h1-15,20,26H,16-19,21H2,(H,37,44)(H,38,39,40,41)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	144	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories					Assay Description Purified recombinant human Akt1, Akt2, and Akt3 proteins were monitored for kinase activity in the presence or absence of Akt inhibitors in a 96-well...				Bioorg Med Chem Lett 15: 761-4 (2005) Article DOI: 10.1016/j.bmcl.2004.11.011 BindingDB Entry DOI: 10.7270/Q2TX3CM4
					More data for this Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human))	BDBM15163 (3-(4-{[4-(2-oxo-2,3-dihydro-1H-1,3-benzodiazol-1-y...) Show SMILES OC(=O)c1ccc2nc(-c3ccccc3)c(nc2c1)-c1ccc(CN2CCC(CC2)n2c3ccccc3[nH]c2=O)cc1 Show InChI InChI=1S/C34H29N5O3/c40-33(41)25-14-15-27-29(20-25)36-32(31(35-27)23-6-2-1-3-7-23)24-12-10-22(11-13-24)21-38-18-16-26(17-19-38)39-30-9-5-4-8-28(30)37-34(39)42/h1-15,20,26H,16-19,21H2,(H,37,42)(H,40,41)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	166	n/a	n/a	n/a	n/a	7.5	22
Merck Research Laboratories					Assay Description Purified recombinant human Akt1, Akt2, and Akt3 proteins were monitored for kinase activity in the presence or absence of Akt inhibitors in a 96-well...				Bioorg Med Chem Lett 15: 761-4 (2005) Article DOI: 10.1016/j.bmcl.2004.11.011 BindingDB Entry DOI: 10.7270/Q2TX3CM4
					More data for this Ligand-Target Pair
RAC-beta serine/threonine-protein kinase (Homo sapiens (Human))	BDBM15169 (1-{1-[(4-{7-phenyl-1H-imidazo[4,5-g]quinoxalin-6-y...) Show SMILES O=c1[nH]c2ccccc2n1C1CCN(Cc2ccc(cc2)-c2nc3cc4[nH]cnc4cc3nc2-c2ccccc2)CC1 Show InChI InChI=1S/C34H29N7O/c42-34-39-26-8-4-5-9-31(26)41(34)25-14-16-40(17-15-25)20-22-10-12-24(13-11-22)33-32(23-6-2-1-3-7-23)37-29-18-27-28(36-21-35-27)19-30(29)38-33/h1-13,18-19,21,25H,14-17,20H2,(H,35,36)(H,39,42)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase MCE MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	210	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories					Assay Description Purified recombinant human Akt1, Akt2, and Akt3 proteins were monitored for kinase activity in the presence or absence of Akt inhibitors in a 96-well...				Bioorg Med Chem Lett 15: 761-4 (2005) Article DOI: 10.1016/j.bmcl.2004.11.011 BindingDB Entry DOI: 10.7270/Q2TX3CM4
					More data for this Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human))	BDBM15162 (2-(4-{[4-(2-oxo-2,3-dihydro-1H-1,3-benzodiazol-1-y...) Show SMILES OC(=O)c1ccc2nc(-c3ccc(CN4CCC(CC4)n4c5ccccc5[nH]c4=O)cc3)c(nc2c1)-c1ccccc1 Show InChI InChI=1S/C34H29N5O3/c40-33(41)25-14-15-27-29(20-25)36-31(23-6-2-1-3-7-23)32(35-27)24-12-10-22(11-13-24)21-38-18-16-26(17-19-38)39-30-9-5-4-8-28(30)37-34(39)42/h1-15,20,26H,16-19,21H2,(H,37,42)(H,40,41)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	240	n/a	n/a	n/a	n/a	7.5	22
Merck Research Laboratories					Assay Description Purified recombinant human Akt1, Akt2, and Akt3 proteins were monitored for kinase activity in the presence or absence of Akt inhibitors in a 96-well...				Bioorg Med Chem Lett 15: 761-4 (2005) Article DOI: 10.1016/j.bmcl.2004.11.011 BindingDB Entry DOI: 10.7270/Q2TX3CM4
					More data for this Ligand-Target Pair
RAC-beta serine/threonine-protein kinase (Homo sapiens (Human))	BDBM15162 (2-(4-{[4-(2-oxo-2,3-dihydro-1H-1,3-benzodiazol-1-y...) Show SMILES OC(=O)c1ccc2nc(-c3ccc(CN4CCC(CC4)n4c5ccccc5[nH]c4=O)cc3)c(nc2c1)-c1ccccc1 Show InChI InChI=1S/C34H29N5O3/c40-33(41)25-14-15-27-29(20-25)36-31(23-6-2-1-3-7-23)32(35-27)24-12-10-22(11-13-24)21-38-18-16-26(17-19-38)39-30-9-5-4-8-28(30)37-34(39)42/h1-15,20,26H,16-19,21H2,(H,37,42)(H,40,41)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	281	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories					Assay Description Purified recombinant human Akt1, Akt2, and Akt3 proteins were monitored for kinase activity in the presence or absence of Akt inhibitors in a 96-well...				Bioorg Med Chem Lett 15: 761-4 (2005) Article DOI: 10.1016/j.bmcl.2004.11.011 BindingDB Entry DOI: 10.7270/Q2TX3CM4
					More data for this Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human))	BDBM15149 (1-(1-{[4-(3-phenylquinoxalin-2-yl)phenyl]methyl}pi...) Show SMILES O=c1[nH]c2ccccc2n1C1CCN(Cc2ccc(cc2)-c2nc3ccccc3nc2-c2ccccc2)CC1 Show InChI InChI=1S/C33H29N5O/c39-33-36-29-12-6-7-13-30(29)38(33)26-18-20-37(21-19-26)22-23-14-16-25(17-15-23)32-31(24-8-2-1-3-9-24)34-27-10-4-5-11-28(27)35-32/h1-17,26H,18-22H2,(H,36,39)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	290	n/a	n/a	n/a	n/a	7.5	22
Merck Research Laboratories					Assay Description Purified recombinant human Akt1, Akt2, and Akt3 proteins were monitored for kinase activity in the presence or absence of Akt inhibitors in a 96-well...				Bioorg Med Chem Lett 15: 761-4 (2005) Article DOI: 10.1016/j.bmcl.2004.11.011 BindingDB Entry DOI: 10.7270/Q2TX3CM4
					More data for this Ligand-Target Pair
RAC-beta serine/threonine-protein kinase (Homo sapiens (Human))	BDBM15168 (1-{1-[(4-{7-phenyl-1H-pyrazolo[3,4-g]quinoxalin-6-...) Show SMILES O=c1[nH]c2ccccc2n1C1CCN(Cc2ccc(cc2)-c2nc3cc4cn[nH]c4cc3nc2-c2ccccc2)CC1 Show InChI InChI=1S/C34H29N7O/c42-34-38-27-8-4-5-9-31(27)41(34)26-14-16-40(17-15-26)21-22-10-12-24(13-11-22)33-32(23-6-2-1-3-7-23)37-30-19-28-25(20-35-39-28)18-29(30)36-33/h1-13,18-20,26H,14-17,21H2,(H,35,39)(H,38,42)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	300	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories					Assay Description Purified recombinant human Akt1, Akt2, and Akt3 proteins were monitored for kinase activity in the presence or absence of Akt inhibitors in a 96-well...				Bioorg Med Chem Lett 15: 761-4 (2005) Article DOI: 10.1016/j.bmcl.2004.11.011 BindingDB Entry DOI: 10.7270/Q2TX3CM4
					More data for this Ligand-Target Pair
RAC-beta serine/threonine-protein kinase (Homo sapiens (Human))	BDBM15161 (1-[1-({4-[5-(2-methylpropyl)-6-oxo-3-phenyl-1,6-di...) Show SMILES CC(C)Cc1nc(-c2ccccc2)c([nH]c1=O)-c1ccc(CN2CCC(CC2)n2c3ccccc3[nH]c2=O)cc1 Show InChI InChI=1S/C33H35N5O2/c1-22(2)20-28-32(39)36-31(30(34-28)24-8-4-3-5-9-24)25-14-12-23(13-15-25)21-37-18-16-26(17-19-37)38-29-11-7-6-10-27(29)35-33(38)40/h3-15,22,26H,16-21H2,1-2H3,(H,35,40)(H,36,39)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	325	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories					Assay Description Purified recombinant human Akt1, Akt2, and Akt3 proteins were monitored for kinase activity in the presence or absence of Akt inhibitors in a 96-well...				Bioorg Med Chem Lett 15: 761-4 (2005) Article DOI: 10.1016/j.bmcl.2004.11.011 BindingDB Entry DOI: 10.7270/Q2TX3CM4
					More data for this Ligand-Target Pair
RAC-beta serine/threonine-protein kinase (Homo sapiens (Human))	BDBM15167 (1-[1-({4-[7-(2-methyl-2H-1,2,3,4-tetrazol-5-yl)-3-...) Show SMILES Cn1nnc(n1)-c1ccc2nc(-c3ccccc3)c(nc2c1)-c1ccc(CN2CCC(CC2)n2c3ccccc3[nH]c2=O)cc1 Show InChI InChI=1S/C35H31N9O/c1-42-40-34(39-41-42)26-15-16-28-30(21-26)37-33(32(36-28)24-7-3-2-4-8-24)25-13-11-23(12-14-25)22-43-19-17-27(18-20-43)44-31-10-6-5-9-29(31)38-35(44)45/h2-16,21,27H,17-20,22H2,1H3,(H,38,45)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	332	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories					Assay Description Purified recombinant human Akt1, Akt2, and Akt3 proteins were monitored for kinase activity in the presence or absence of Akt inhibitors in a 96-well...				Bioorg Med Chem Lett 15: 761-4 (2005) Article DOI: 10.1016/j.bmcl.2004.11.011 BindingDB Entry DOI: 10.7270/Q2TX3CM4
					More data for this Ligand-Target Pair
RAC-beta serine/threonine-protein kinase (Homo sapiens (Human))	BDBM15163 (3-(4-{[4-(2-oxo-2,3-dihydro-1H-1,3-benzodiazol-1-y...) Show SMILES OC(=O)c1ccc2nc(-c3ccccc3)c(nc2c1)-c1ccc(CN2CCC(CC2)n2c3ccccc3[nH]c2=O)cc1 Show InChI InChI=1S/C34H29N5O3/c40-33(41)25-14-15-27-29(20-25)36-32(31(35-27)23-6-2-1-3-7-23)24-12-10-22(11-13-24)21-38-18-16-26(17-19-38)39-30-9-5-4-8-28(30)37-34(39)42/h1-15,20,26H,16-19,21H2,(H,37,42)(H,40,41)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	388	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories					Assay Description Purified recombinant human Akt1, Akt2, and Akt3 proteins were monitored for kinase activity in the presence or absence of Akt inhibitors in a 96-well...				Bioorg Med Chem Lett 15: 761-4 (2005) Article DOI: 10.1016/j.bmcl.2004.11.011 BindingDB Entry DOI: 10.7270/Q2TX3CM4
					More data for this Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human))	BDBM15152 (1-(1-{[4-(6-methyl-5-oxo-3-phenyl-4,5-dihydropyraz...) Show SMILES Cc1nc(-c2ccc(CN3CCC(CC3)n3c4ccccc4[nH]c3=O)cc2)c([nH]c1=O)-c1ccccc1 Show InChI InChI=1S/C30H29N5O2/c1-20-29(36)33-28(22-7-3-2-4-8-22)27(31-20)23-13-11-21(12-14-23)19-34-17-15-24(16-18-34)35-26-10-6-5-9-25(26)32-30(35)37/h2-14,24H,15-19H2,1H3,(H,32,37)(H,33,36)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	760	n/a	n/a	n/a	n/a	7.5	22
Merck Research Laboratories					Assay Description Purified recombinant human Akt1, Akt2, and Akt3 proteins were monitored for kinase activity in the presence or absence of Akt inhibitors in a 96-well...				Bioorg Med Chem Lett 15: 761-4 (2005) Article DOI: 10.1016/j.bmcl.2004.11.011 BindingDB Entry DOI: 10.7270/Q2TX3CM4
					More data for this Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human))	BDBM15153 (1-(1-{[4-(5-methyl-6-oxo-3-phenyl-1,6-dihydropyraz...) Show SMILES Cc1nc(-c2ccccc2)c([nH]c1=O)-c1ccc(CN2CCC(CC2)n2c3ccccc3[nH]c2=O)cc1 Show InChI InChI=1S/C30H29N5O2/c1-20-29(36)33-28(27(31-20)22-7-3-2-4-8-22)23-13-11-21(12-14-23)19-34-17-15-24(16-18-34)35-26-10-6-5-9-25(26)32-30(35)37/h2-14,24H,15-19H2,1H3,(H,32,37)(H,33,36)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a	7.5	22
Merck Research Laboratories					Assay Description Purified recombinant human Akt1, Akt2, and Akt3 proteins were monitored for kinase activity in the presence or absence of Akt inhibitors in a 96-well...				Bioorg Med Chem Lett 15: 761-4 (2005) Article DOI: 10.1016/j.bmcl.2004.11.011 BindingDB Entry DOI: 10.7270/Q2TX3CM4
					More data for this Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human))	BDBM15166 (1-[1-({4-[6-(2-methyl-2H-1,2,3,4-tetrazol-5-yl)-3-...) Show SMILES Cn1nnc(n1)-c1ccc2nc(-c3ccc(CN4CCC(CC4)n4c5ccccc5[nH]c4=O)cc3)c(nc2c1)-c1ccccc1 Show InChI InChI=1S/C35H31N9O/c1-42-40-34(39-41-42)26-15-16-28-30(21-26)37-32(24-7-3-2-4-8-24)33(36-28)25-13-11-23(12-14-25)22-43-19-17-27(18-20-43)44-31-10-6-5-9-29(31)38-35(44)45/h2-16,21,27H,17-20,22H2,1H3,(H,38,45)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.09E+3	n/a	n/a	n/a	n/a	7.5	22
Merck Research Laboratories					Assay Description Purified recombinant human Akt1, Akt2, and Akt3 proteins were monitored for kinase activity in the presence or absence of Akt inhibitors in a 96-well...				Bioorg Med Chem Lett 15: 761-4 (2005) Article DOI: 10.1016/j.bmcl.2004.11.011 BindingDB Entry DOI: 10.7270/Q2TX3CM4
					More data for this Ligand-Target Pair
RAC-beta serine/threonine-protein kinase (Homo sapiens (Human))	BDBM15153 (1-(1-{[4-(5-methyl-6-oxo-3-phenyl-1,6-dihydropyraz...) Show SMILES Cc1nc(-c2ccccc2)c([nH]c1=O)-c1ccc(CN2CCC(CC2)n2c3ccccc3[nH]c2=O)cc1 Show InChI InChI=1S/C30H29N5O2/c1-20-29(36)33-28(27(31-20)22-7-3-2-4-8-22)23-13-11-21(12-14-23)19-34-17-15-24(16-18-34)35-26-10-6-5-9-25(26)32-30(35)37/h2-14,24H,15-19H2,1H3,(H,32,37)(H,33,36)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.18E+3	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories					Assay Description Purified recombinant human Akt1, Akt2, and Akt3 proteins were monitored for kinase activity in the presence or absence of Akt inhibitors in a 96-well...				Bioorg Med Chem Lett 15: 761-4 (2005) Article DOI: 10.1016/j.bmcl.2004.11.011 BindingDB Entry DOI: 10.7270/Q2TX3CM4
					More data for this Ligand-Target Pair
RAC-gamma serine/threonine-protein kinase (Homo sapiens (Human))	BDBM15164 (1-[1-({4-[3-phenyl-6-(2H-1,2,3,4-tetrazol-5-yl)qui...) Show SMILES O=c1[nH]c2ccccc2n1C1CCN(Cc2ccc(cc2)-c2nc3ccc(cc3nc2-c2ccccc2)-c2nnn[nH]2)CC1 Show InChI InChI=1S/C34H29N9O/c44-34-37-28-8-4-5-9-30(28)43(34)26-16-18-42(19-17-26)21-22-10-12-24(13-11-22)32-31(23-6-2-1-3-7-23)36-29-20-25(14-15-27(29)35-32)33-38-40-41-39-33/h1-15,20,26H,16-19,21H2,(H,37,44)(H,38,39,40,41)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.23E+3	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories					Assay Description Purified recombinant human Akt1, Akt2, and Akt3 proteins were monitored for kinase activity in the presence or absence of Akt inhibitors in a 96-well...				Bioorg Med Chem Lett 15: 761-4 (2005) Article DOI: 10.1016/j.bmcl.2004.11.011 BindingDB Entry DOI: 10.7270/Q2TX3CM4
					More data for this Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human))	BDBM15151 (1-(1-{[4-(6-oxo-3-phenyl-1,6-dihydropyrazin-2-yl)p...) Show SMILES O=c1[nH]c2ccccc2n1C1CCN(Cc2ccc(cc2)-c2[nH]c(=O)cnc2-c2ccccc2)CC1 Show InChI InChI=1S/C29H27N5O2/c35-26-18-30-27(21-6-2-1-3-7-21)28(32-26)22-12-10-20(11-13-22)19-33-16-14-23(15-17-33)34-25-9-5-4-8-24(25)31-29(34)36/h1-13,18,23H,14-17,19H2,(H,31,36)(H,32,35)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.50E+3	n/a	n/a	n/a	n/a	7.5	22
Merck Research Laboratories					Assay Description Purified recombinant human Akt1, Akt2, and Akt3 proteins were monitored for kinase activity in the presence or absence of Akt inhibitors in a 96-well...				Bioorg Med Chem Lett 15: 761-4 (2005) Article DOI: 10.1016/j.bmcl.2004.11.011 BindingDB Entry DOI: 10.7270/Q2TX3CM4
					More data for this Ligand-Target Pair
RAC-gamma serine/threonine-protein kinase (Homo sapiens (Human))	BDBM15165 (1-[1-({4-[3-phenyl-7-(2H-1,2,3,4-tetrazol-5-yl)qui...) Show SMILES O=c1[nH]c2ccccc2n1C1CCN(Cc2ccc(cc2)-c2nc3cc(ccc3nc2-c2ccccc2)-c2nnn[nH]2)CC1 Show InChI InChI=1S/C34H29N9O/c44-34-37-28-8-4-5-9-30(28)43(34)26-16-18-42(19-17-26)21-22-10-12-24(13-11-22)32-31(23-6-2-1-3-7-23)35-27-15-14-25(20-29(27)36-32)33-38-40-41-39-33/h1-15,20,26H,16-19,21H2,(H,37,44)(H,38,39,40,41)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.61E+3	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories					Assay Description Purified recombinant human Akt1, Akt2, and Akt3 proteins were monitored for kinase activity in the presence or absence of Akt inhibitors in a 96-well...				Bioorg Med Chem Lett 15: 761-4 (2005) Article DOI: 10.1016/j.bmcl.2004.11.011 BindingDB Entry DOI: 10.7270/Q2TX3CM4
					More data for this Ligand-Target Pair
RAC-beta serine/threonine-protein kinase (Homo sapiens (Human))	BDBM15155 (1-(1-{[4-(5-benzyl-6-oxo-3-phenyl-1,6-dihydropyraz...) Show SMILES O=c1[nH]c2ccccc2n1C1CCN(Cc2ccc(cc2)-c2[nH]c(=O)c(Cc3ccccc3)nc2-c2ccccc2)CC1 Show InChI InChI=1S/C36H33N5O2/c42-35-31(23-25-9-3-1-4-10-25)37-33(27-11-5-2-6-12-27)34(39-35)28-17-15-26(16-18-28)24-40-21-19-29(20-22-40)41-32-14-8-7-13-30(32)38-36(41)43/h1-18,29H,19-24H2,(H,38,43)(H,39,42)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.76E+3	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories					Assay Description Purified recombinant human Akt1, Akt2, and Akt3 proteins were monitored for kinase activity in the presence or absence of Akt inhibitors in a 96-well...				Bioorg Med Chem Lett 15: 761-4 (2005) Article DOI: 10.1016/j.bmcl.2004.11.011 BindingDB Entry DOI: 10.7270/Q2TX3CM4
					More data for this Ligand-Target Pair
RAC-beta serine/threonine-protein kinase (Homo sapiens (Human))	BDBM15166 (1-[1-({4-[6-(2-methyl-2H-1,2,3,4-tetrazol-5-yl)-3-...) Show SMILES Cn1nnc(n1)-c1ccc2nc(-c3ccc(CN4CCC(CC4)n4c5ccccc5[nH]c4=O)cc3)c(nc2c1)-c1ccccc1 Show InChI InChI=1S/C35H31N9O/c1-42-40-34(39-41-42)26-15-16-28-30(21-26)37-32(24-7-3-2-4-8-24)33(36-28)25-13-11-23(12-14-25)22-43-19-17-27(18-20-43)44-31-10-6-5-9-29(31)38-35(44)45/h2-16,21,27H,17-20,22H2,1H3,(H,38,45)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.88E+3	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories					Assay Description Purified recombinant human Akt1, Akt2, and Akt3 proteins were monitored for kinase activity in the presence or absence of Akt inhibitors in a 96-well...				Bioorg Med Chem Lett 15: 761-4 (2005) Article DOI: 10.1016/j.bmcl.2004.11.011 BindingDB Entry DOI: 10.7270/Q2TX3CM4
					More data for this Ligand-Target Pair
RAC-beta serine/threonine-protein kinase (Homo sapiens (Human))	BDBM15149 (1-(1-{[4-(3-phenylquinoxalin-2-yl)phenyl]methyl}pi...) Show SMILES O=c1[nH]c2ccccc2n1C1CCN(Cc2ccc(cc2)-c2nc3ccccc3nc2-c2ccccc2)CC1 Show InChI InChI=1S/C33H29N5O/c39-33-36-29-12-6-7-13-30(29)38(33)26-18-20-37(21-19-26)22-23-14-16-25(17-15-23)32-31(24-8-2-1-3-9-24)34-27-10-4-5-11-28(27)35-32/h1-17,26H,18-22H2,(H,36,39)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2.09E+3	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories					Assay Description Purified recombinant human Akt1, Akt2, and Akt3 proteins were monitored for kinase activity in the presence or absence of Akt inhibitors in a 96-well...				Bioorg Med Chem Lett 15: 761-4 (2005) Article DOI: 10.1016/j.bmcl.2004.11.011 BindingDB Entry DOI: 10.7270/Q2TX3CM4
					More data for this Ligand-Target Pair
RAC-gamma serine/threonine-protein kinase (Homo sapiens (Human))	BDBM15169 (1-{1-[(4-{7-phenyl-1H-imidazo[4,5-g]quinoxalin-6-y...) Show SMILES O=c1[nH]c2ccccc2n1C1CCN(Cc2ccc(cc2)-c2nc3cc4[nH]cnc4cc3nc2-c2ccccc2)CC1 Show InChI InChI=1S/C34H29N7O/c42-34-39-26-8-4-5-9-31(26)41(34)25-14-16-40(17-15-25)20-22-10-12-24(13-11-22)33-32(23-6-2-1-3-7-23)37-29-18-27-28(36-21-35-27)19-30(29)38-33/h1-13,18-19,21,25H,14-17,20H2,(H,35,36)(H,39,42)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase MCE MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	2.12E+3	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories					Assay Description Purified recombinant human Akt1, Akt2, and Akt3 proteins were monitored for kinase activity in the presence or absence of Akt inhibitors in a 96-well...				Bioorg Med Chem Lett 15: 761-4 (2005) Article DOI: 10.1016/j.bmcl.2004.11.011 BindingDB Entry DOI: 10.7270/Q2TX3CM4
					More data for this Ligand-Target Pair
RAC-gamma serine/threonine-protein kinase (Homo sapiens (Human))	BDBM15168 (1-{1-[(4-{7-phenyl-1H-pyrazolo[3,4-g]quinoxalin-6-...) Show SMILES O=c1[nH]c2ccccc2n1C1CCN(Cc2ccc(cc2)-c2nc3cc4cn[nH]c4cc3nc2-c2ccccc2)CC1 Show InChI InChI=1S/C34H29N7O/c42-34-38-27-8-4-5-9-31(27)41(34)26-14-16-40(17-15-26)21-22-10-12-24(13-11-22)33-32(23-6-2-1-3-7-23)37-30-19-28-25(20-35-39-28)18-29(30)36-33/h1-13,18-20,26H,14-17,21H2,(H,35,39)(H,38,42)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories					Assay Description Purified recombinant human Akt1, Akt2, and Akt3 proteins were monitored for kinase activity in the presence or absence of Akt inhibitors in a 96-well...				Bioorg Med Chem Lett 15: 761-4 (2005) Article DOI: 10.1016/j.bmcl.2004.11.011 BindingDB Entry DOI: 10.7270/Q2TX3CM4
					More data for this Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human))	BDBM15150 (1-(1-{[4-(5-oxo-3-phenyl-4,5-dihydropyrazin-2-yl)p...) Show SMILES O=c1[nH]c2ccccc2n1C1CCN(Cc2ccc(cc2)-c2ncc(=O)[nH]c2-c2ccccc2)CC1 Show InChI InChI=1S/C29H27N5O2/c35-26-18-30-27(28(32-26)21-6-2-1-3-7-21)22-12-10-20(11-13-22)19-33-16-14-23(15-17-33)34-25-9-5-4-8-24(25)31-29(34)36/h1-13,18,23H,14-17,19H2,(H,31,36)(H,32,35)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.03E+3	n/a	n/a	n/a	n/a	7.5	22
Merck Research Laboratories					Assay Description Purified recombinant human Akt1, Akt2, and Akt3 proteins were monitored for kinase activity in the presence or absence of Akt inhibitors in a 96-well...				Bioorg Med Chem Lett 15: 761-4 (2005) Article DOI: 10.1016/j.bmcl.2004.11.011 BindingDB Entry DOI: 10.7270/Q2TX3CM4
					More data for this Ligand-Target Pair
RAC-gamma serine/threonine-protein kinase (Homo sapiens (Human))	BDBM15163 (3-(4-{[4-(2-oxo-2,3-dihydro-1H-1,3-benzodiazol-1-y...) Show SMILES OC(=O)c1ccc2nc(-c3ccccc3)c(nc2c1)-c1ccc(CN2CCC(CC2)n2c3ccccc3[nH]c2=O)cc1 Show InChI InChI=1S/C34H29N5O3/c40-33(41)25-14-15-27-29(20-25)36-32(31(35-27)23-6-2-1-3-7-23)24-12-10-22(11-13-24)21-38-18-16-26(17-19-38)39-30-9-5-4-8-28(30)37-34(39)42/h1-15,20,26H,16-19,21H2,(H,37,42)(H,40,41)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	3.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories					Assay Description Purified recombinant human Akt1, Akt2, and Akt3 proteins were monitored for kinase activity in the presence or absence of Akt inhibitors in a 96-well...				Bioorg Med Chem Lett 15: 761-4 (2005) Article DOI: 10.1016/j.bmcl.2004.11.011 BindingDB Entry DOI: 10.7270/Q2TX3CM4
					More data for this Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human))	BDBM15148 (2,3-diphenylquinoxaline 1 | 2-[4-(3-phenylquinoxal...) Show SMILES CC(C)(N)c1ccc(cc1)-c1nc2ccccc2nc1-c1ccccc1 Show InChI InChI=1S/C23H21N3/c1-23(2,24)18-14-12-17(13-15-18)22-21(16-8-4-3-5-9-16)25-19-10-6-7-11-20(19)26-22/h3-15H,24H2,1-2H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	3.40E+3	n/a	n/a	n/a	n/a	7.5	22
Merck Research Laboratories					Assay Description Purified recombinant human Akt1, Akt2, and Akt3 proteins were monitored for kinase activity in the presence or absence of Akt inhibitors in a 96-well...				Bioorg Med Chem Lett 15: 761-4 (2005) Article DOI: 10.1016/j.bmcl.2004.11.011 BindingDB Entry DOI: 10.7270/Q2TX3CM4
					More data for this Ligand-Target Pair
RAC-gamma serine/threonine-protein kinase (Homo sapiens (Human))	BDBM15155 (1-(1-{[4-(5-benzyl-6-oxo-3-phenyl-1,6-dihydropyraz...) Show SMILES O=c1[nH]c2ccccc2n1C1CCN(Cc2ccc(cc2)-c2[nH]c(=O)c(Cc3ccccc3)nc2-c2ccccc2)CC1 Show InChI InChI=1S/C36H33N5O2/c42-35-31(23-25-9-3-1-4-10-25)37-33(27-11-5-2-6-12-27)34(39-35)28-17-15-26(16-18-28)24-40-21-19-29(20-22-40)41-32-14-8-7-13-30(32)38-36(41)43/h1-18,29H,19-24H2,(H,38,43)(H,39,42)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.97E+3	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories					Assay Description Purified recombinant human Akt1, Akt2, and Akt3 proteins were monitored for kinase activity in the presence or absence of Akt inhibitors in a 96-well...				Bioorg Med Chem Lett 15: 761-4 (2005) Article DOI: 10.1016/j.bmcl.2004.11.011 BindingDB Entry DOI: 10.7270/Q2TX3CM4
					More data for this Ligand-Target Pair
RAC-beta serine/threonine-protein kinase (Homo sapiens (Human))	BDBM15159 (1-[1-({4-[5-(butan-2-yl)-6-oxo-3-phenyl-1,6-dihydr...) Show SMILES CCC(C)c1nc(-c2ccccc2)c([nH]c1=O)-c1ccc(CN2CCC(CC2)n2c3ccccc3[nH]c2=O)cc1 Show InChI InChI=1S/C33H35N5O2/c1-3-22(2)29-32(39)36-31(30(35-29)24-9-5-4-6-10-24)25-15-13-23(14-16-25)21-37-19-17-26(18-20-37)38-28-12-8-7-11-27(28)34-33(38)40/h4-16,22,26H,3,17-21H2,1-2H3,(H,34,40)(H,36,39)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.52E+3	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories					Assay Description Purified recombinant human Akt1, Akt2, and Akt3 proteins were monitored for kinase activity in the presence or absence of Akt inhibitors in a 96-well...				Bioorg Med Chem Lett 15: 761-4 (2005) Article DOI: 10.1016/j.bmcl.2004.11.011 BindingDB Entry DOI: 10.7270/Q2TX3CM4
					More data for this Ligand-Target Pair
RAC-beta serine/threonine-protein kinase (Homo sapiens (Human))	BDBM15157 (1-{1-[(4-{5-[(4-hydroxyphenyl)methyl]-6-oxo-3-phen...) Show SMILES Oc1ccc(Cc2nc(-c3ccccc3)c([nH]c2=O)-c2ccc(CN3CCC(CC3)n3c4ccccc4[nH]c3=O)cc2)cc1 Show InChI InChI=1S/C36H33N5O3/c42-29-16-12-24(13-17-29)22-31-35(43)39-34(33(37-31)26-6-2-1-3-7-26)27-14-10-25(11-15-27)23-40-20-18-28(19-21-40)41-32-9-5-4-8-30(32)38-36(41)44/h1-17,28,42H,18-23H2,(H,38,44)(H,39,43)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.41E+3	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories					Assay Description Purified recombinant human Akt1, Akt2, and Akt3 proteins were monitored for kinase activity in the presence or absence of Akt inhibitors in a 96-well...				Bioorg Med Chem Lett 15: 761-4 (2005) Article DOI: 10.1016/j.bmcl.2004.11.011 BindingDB Entry DOI: 10.7270/Q2TX3CM4
					More data for this Ligand-Target Pair
RAC-beta serine/threonine-protein kinase (Homo sapiens (Human))	BDBM15150 (1-(1-{[4-(5-oxo-3-phenyl-4,5-dihydropyrazin-2-yl)p...) Show SMILES O=c1[nH]c2ccccc2n1C1CCN(Cc2ccc(cc2)-c2ncc(=O)[nH]c2-c2ccccc2)CC1 Show InChI InChI=1S/C29H27N5O2/c35-26-18-30-27(28(32-26)21-6-2-1-3-7-21)22-12-10-20(11-13-22)19-33-16-14-23(15-17-33)34-25-9-5-4-8-24(25)31-29(34)36/h1-13,18,23H,14-17,19H2,(H,31,36)(H,32,35)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.57E+4	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories					Assay Description Purified recombinant human Akt1, Akt2, and Akt3 proteins were monitored for kinase activity in the presence or absence of Akt inhibitors in a 96-well...				Bioorg Med Chem Lett 15: 761-4 (2005) Article DOI: 10.1016/j.bmcl.2004.11.011 BindingDB Entry DOI: 10.7270/Q2TX3CM4
					More data for this Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human))	BDBM15154 (1-(1-{[4-(6-benzyl-5-oxo-3-phenyl-4,5-dihydropyraz...) Show SMILES O=c1[nH]c2ccccc2n1C1CCN(Cc2ccc(cc2)-c2nc(Cc3ccccc3)c(=O)[nH]c2-c2ccccc2)CC1 Show InChI InChI=1S/C36H33N5O2/c42-35-31(23-25-9-3-1-4-10-25)37-33(34(39-35)27-11-5-2-6-12-27)28-17-15-26(16-18-28)24-40-21-19-29(20-22-40)41-32-14-8-7-13-30(32)38-36(41)43/h1-18,29H,19-24H2,(H,38,43)(H,39,42)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.70E+4	n/a	n/a	n/a	n/a	7.5	22
Merck Research Laboratories					Assay Description Purified recombinant human Akt1, Akt2, and Akt3 proteins were monitored for kinase activity in the presence or absence of Akt inhibitors in a 96-well...				Bioorg Med Chem Lett 15: 761-4 (2005) Article DOI: 10.1016/j.bmcl.2004.11.011 BindingDB Entry DOI: 10.7270/Q2TX3CM4
					More data for this Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human))	BDBM15158 (1-[1-({4-[6-(butan-2-yl)-5-oxo-3-phenyl-4,5-dihydr...) Show SMILES CCC(C)c1nc(-c2ccc(CN3CCC(CC3)n3c4ccccc4[nH]c3=O)cc2)c([nH]c1=O)-c1ccccc1 Show InChI InChI=1S/C33H35N5O2/c1-3-22(2)29-32(39)36-31(24-9-5-4-6-10-24)30(35-29)25-15-13-23(14-16-25)21-37-19-17-26(18-20-37)38-28-12-8-7-11-27(28)34-33(38)40/h4-16,22,26H,3,17-21H2,1-2H3,(H,34,40)(H,36,39)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.70E+4	n/a	n/a	n/a	n/a	7.5	22
Merck Research Laboratories					Assay Description Purified recombinant human Akt1, Akt2, and Akt3 proteins were monitored for kinase activity in the presence or absence of Akt inhibitors in a 96-well...				Bioorg Med Chem Lett 15: 761-4 (2005) Article DOI: 10.1016/j.bmcl.2004.11.011 BindingDB Entry DOI: 10.7270/Q2TX3CM4
					More data for this Ligand-Target Pair
RAC-beta serine/threonine-protein kinase (Homo sapiens (Human))	BDBM15160 (1-[1-({4-[6-(2-methylpropyl)-5-oxo-3-phenyl-4,5-di...) Show SMILES CC(C)Cc1nc(-c2ccc(CN3CCC(CC3)n3c4ccccc4[nH]c3=O)cc2)c([nH]c1=O)-c1ccccc1 Show InChI InChI=1S/C33H35N5O2/c1-22(2)20-28-32(39)36-31(24-8-4-3-5-9-24)30(34-28)25-14-12-23(13-15-25)21-37-18-16-26(17-19-37)38-29-11-7-6-10-27(29)35-33(38)40/h3-15,22,26H,16-21H2,1-2H3,(H,35,40)(H,36,39)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.80E+4	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories					Assay Description Purified recombinant human Akt1, Akt2, and Akt3 proteins were monitored for kinase activity in the presence or absence of Akt inhibitors in a 96-well...				Bioorg Med Chem Lett 15: 761-4 (2005) Article DOI: 10.1016/j.bmcl.2004.11.011 BindingDB Entry DOI: 10.7270/Q2TX3CM4
					More data for this Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human))	BDBM15161 (1-[1-({4-[5-(2-methylpropyl)-6-oxo-3-phenyl-1,6-di...) Show SMILES CC(C)Cc1nc(-c2ccccc2)c([nH]c1=O)-c1ccc(CN2CCC(CC2)n2c3ccccc3[nH]c2=O)cc1 Show InChI InChI=1S/C33H35N5O2/c1-22(2)20-28-32(39)36-31(30(34-28)24-8-4-3-5-9-24)25-14-12-23(13-15-25)21-37-18-16-26(17-19-37)38-29-11-7-6-10-27(29)35-33(38)40/h3-15,22,26H,16-21H2,1-2H3,(H,35,40)(H,36,39)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2.12E+4	n/a	n/a	n/a	n/a	7.5	22
Merck Research Laboratories					Assay Description Purified recombinant human Akt1, Akt2, and Akt3 proteins were monitored for kinase activity in the presence or absence of Akt inhibitors in a 96-well...				Bioorg Med Chem Lett 15: 761-4 (2005) Article DOI: 10.1016/j.bmcl.2004.11.011 BindingDB Entry DOI: 10.7270/Q2TX3CM4
					More data for this Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human))	BDBM15156 (1-{1-[(4-{6-[(4-hydroxyphenyl)methyl]-5-oxo-3-phen...) Show SMILES Oc1ccc(Cc2nc(-c3ccc(CN4CCC(CC4)n4c5ccccc5[nH]c4=O)cc3)c([nH]c2=O)-c2ccccc2)cc1 Show InChI InChI=1S/C36H33N5O3/c42-29-16-12-24(13-17-29)22-31-35(43)39-34(26-6-2-1-3-7-26)33(37-31)27-14-10-25(11-15-27)23-40-20-18-28(19-21-40)41-32-9-5-4-8-30(32)38-36(41)44/h1-17,28,42H,18-23H2,(H,38,44)(H,39,43)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.17E+4	n/a	n/a	n/a	n/a	7.5	22
Merck Research Laboratories					Assay Description Purified recombinant human Akt1, Akt2, and Akt3 proteins were monitored for kinase activity in the presence or absence of Akt inhibitors in a 96-well...				Bioorg Med Chem Lett 15: 761-4 (2005) Article DOI: 10.1016/j.bmcl.2004.11.011 BindingDB Entry DOI: 10.7270/Q2TX3CM4
					More data for this Ligand-Target Pair
RAC-gamma serine/threonine-protein kinase (Homo sapiens (Human))	BDBM15161 (1-[1-({4-[5-(2-methylpropyl)-6-oxo-3-phenyl-1,6-di...) Show SMILES CC(C)Cc1nc(-c2ccccc2)c([nH]c1=O)-c1ccc(CN2CCC(CC2)n2c3ccccc3[nH]c2=O)cc1 Show InChI InChI=1S/C33H35N5O2/c1-22(2)20-28-32(39)36-31(30(34-28)24-8-4-3-5-9-24)25-14-12-23(13-15-25)21-37-18-16-26(17-19-37)38-29-11-7-6-10-27(29)35-33(38)40/h3-15,22,26H,16-21H2,1-2H3,(H,35,40)(H,36,39)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2.19E+4	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories					Assay Description Purified recombinant human Akt1, Akt2, and Akt3 proteins were monitored for kinase activity in the presence or absence of Akt inhibitors in a 96-well...				Bioorg Med Chem Lett 15: 761-4 (2005) Article DOI: 10.1016/j.bmcl.2004.11.011 BindingDB Entry DOI: 10.7270/Q2TX3CM4
					More data for this Ligand-Target Pair
RAC-beta serine/threonine-protein kinase (Homo sapiens (Human))	BDBM15148 (2,3-diphenylquinoxaline 1 | 2-[4-(3-phenylquinoxal...) Show SMILES CC(C)(N)c1ccc(cc1)-c1nc2ccccc2nc1-c1ccccc1 Show InChI InChI=1S/C23H21N3/c1-23(2,24)18-14-12-17(13-15-18)22-21(16-8-4-3-5-9-16)25-19-10-6-7-11-20(19)26-22/h3-15H,24H2,1-2H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	2.30E+4	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories					Assay Description Purified recombinant human Akt1, Akt2, and Akt3 proteins were monitored for kinase activity in the presence or absence of Akt inhibitors in a 96-well...				Bioorg Med Chem Lett 15: 761-4 (2005) Article DOI: 10.1016/j.bmcl.2004.11.011 BindingDB Entry DOI: 10.7270/Q2TX3CM4
					More data for this Ligand-Target Pair
RAC-beta serine/threonine-protein kinase (Homo sapiens (Human))	BDBM15152 (1-(1-{[4-(6-methyl-5-oxo-3-phenyl-4,5-dihydropyraz...) Show SMILES Cc1nc(-c2ccc(CN3CCC(CC3)n3c4ccccc4[nH]c3=O)cc2)c([nH]c1=O)-c1ccccc1 Show InChI InChI=1S/C30H29N5O2/c1-20-29(36)33-28(22-7-3-2-4-8-22)27(31-20)23-13-11-21(12-14-23)19-34-17-15-24(16-18-34)35-26-10-6-5-9-25(26)32-30(35)37/h2-14,24H,15-19H2,1H3,(H,32,37)(H,33,36)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.40E+4	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories					Assay Description Purified recombinant human Akt1, Akt2, and Akt3 proteins were monitored for kinase activity in the presence or absence of Akt inhibitors in a 96-well...				Bioorg Med Chem Lett 15: 761-4 (2005) Article DOI: 10.1016/j.bmcl.2004.11.011 BindingDB Entry DOI: 10.7270/Q2TX3CM4
					More data for this Ligand-Target Pair
RAC-gamma serine/threonine-protein kinase (Homo sapiens (Human))	BDBM15153 (1-(1-{[4-(5-methyl-6-oxo-3-phenyl-1,6-dihydropyraz...) Show SMILES Cc1nc(-c2ccccc2)c([nH]c1=O)-c1ccc(CN2CCC(CC2)n2c3ccccc3[nH]c2=O)cc1 Show InChI InChI=1S/C30H29N5O2/c1-20-29(36)33-28(27(31-20)22-7-3-2-4-8-22)23-13-11-21(12-14-23)19-34-17-15-24(16-18-34)35-26-10-6-5-9-25(26)32-30(35)37/h2-14,24H,15-19H2,1H3,(H,32,37)(H,33,36)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.31E+4	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories					Assay Description Purified recombinant human Akt1, Akt2, and Akt3 proteins were monitored for kinase activity in the presence or absence of Akt inhibitors in a 96-well...				Bioorg Med Chem Lett 15: 761-4 (2005) Article DOI: 10.1016/j.bmcl.2004.11.011 BindingDB Entry DOI: 10.7270/Q2TX3CM4
					More data for this Ligand-Target Pair
RAC-beta serine/threonine-protein kinase (Homo sapiens (Human))	BDBM15156 (1-{1-[(4-{6-[(4-hydroxyphenyl)methyl]-5-oxo-3-phen...) Show SMILES Oc1ccc(Cc2nc(-c3ccc(CN4CCC(CC4)n4c5ccccc5[nH]c4=O)cc3)c([nH]c2=O)-c2ccccc2)cc1 Show InChI InChI=1S/C36H33N5O3/c42-29-16-12-24(13-17-29)22-31-35(43)39-34(26-6-2-1-3-7-26)33(37-31)27-14-10-25(11-15-27)23-40-20-18-28(19-21-40)41-32-9-5-4-8-30(32)38-36(41)44/h1-17,28,42H,18-23H2,(H,38,44)(H,39,43)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.53E+4	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories					Assay Description Purified recombinant human Akt1, Akt2, and Akt3 proteins were monitored for kinase activity in the presence or absence of Akt inhibitors in a 96-well...				Bioorg Med Chem Lett 15: 761-4 (2005) Article DOI: 10.1016/j.bmcl.2004.11.011 BindingDB Entry DOI: 10.7270/Q2TX3CM4
					More data for this Ligand-Target Pair
RAC-gamma serine/threonine-protein kinase (Homo sapiens (Human))	BDBM15157 (1-{1-[(4-{5-[(4-hydroxyphenyl)methyl]-6-oxo-3-phen...) Show SMILES Oc1ccc(Cc2nc(-c3ccccc3)c([nH]c2=O)-c2ccc(CN3CCC(CC3)n3c4ccccc4[nH]c3=O)cc2)cc1 Show InChI InChI=1S/C36H33N5O3/c42-29-16-12-24(13-17-29)22-31-35(43)39-34(33(37-31)26-6-2-1-3-7-26)27-14-10-25(11-15-27)23-40-20-18-28(19-21-40)41-32-9-5-4-8-30(32)38-36(41)44/h1-17,28,42H,18-23H2,(H,38,44)(H,39,43)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories					Assay Description Purified recombinant human Akt1, Akt2, and Akt3 proteins were monitored for kinase activity in the presence or absence of Akt inhibitors in a 96-well...				Bioorg Med Chem Lett 15: 761-4 (2005) Article DOI: 10.1016/j.bmcl.2004.11.011 BindingDB Entry DOI: 10.7270/Q2TX3CM4
					More data for this Ligand-Target Pair
RAC-gamma serine/threonine-protein kinase (Homo sapiens (Human))	BDBM15158 (1-[1-({4-[6-(butan-2-yl)-5-oxo-3-phenyl-4,5-dihydr...) Show SMILES CCC(C)c1nc(-c2ccc(CN3CCC(CC3)n3c4ccccc4[nH]c3=O)cc2)c([nH]c1=O)-c1ccccc1 Show InChI InChI=1S/C33H35N5O2/c1-3-22(2)29-32(39)36-31(24-9-5-4-6-10-24)30(35-29)25-15-13-23(14-16-25)21-37-19-17-26(18-20-37)38-28-12-8-7-11-27(28)34-33(38)40/h4-16,22,26H,3,17-21H2,1-2H3,(H,34,40)(H,36,39)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories					Assay Description Purified recombinant human Akt1, Akt2, and Akt3 proteins were monitored for kinase activity in the presence or absence of Akt inhibitors in a 96-well...				Bioorg Med Chem Lett 15: 761-4 (2005) Article DOI: 10.1016/j.bmcl.2004.11.011 BindingDB Entry DOI: 10.7270/Q2TX3CM4
					More data for this Ligand-Target Pair
RAC-gamma serine/threonine-protein kinase (Homo sapiens (Human))	BDBM15159 (1-[1-({4-[5-(butan-2-yl)-6-oxo-3-phenyl-1,6-dihydr...) Show SMILES CCC(C)c1nc(-c2ccccc2)c([nH]c1=O)-c1ccc(CN2CCC(CC2)n2c3ccccc3[nH]c2=O)cc1 Show InChI InChI=1S/C33H35N5O2/c1-3-22(2)29-32(39)36-31(30(35-29)24-9-5-4-6-10-24)25-15-13-23(14-16-25)21-37-19-17-26(18-20-37)38-28-12-8-7-11-27(28)34-33(38)40/h4-16,22,26H,3,17-21H2,1-2H3,(H,34,40)(H,36,39)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories					Assay Description Purified recombinant human Akt1, Akt2, and Akt3 proteins were monitored for kinase activity in the presence or absence of Akt inhibitors in a 96-well...				Bioorg Med Chem Lett 15: 761-4 (2005) Article DOI: 10.1016/j.bmcl.2004.11.011 BindingDB Entry DOI: 10.7270/Q2TX3CM4
					More data for this Ligand-Target Pair
RAC-gamma serine/threonine-protein kinase (Homo sapiens (Human))	BDBM15160 (1-[1-({4-[6-(2-methylpropyl)-5-oxo-3-phenyl-4,5-di...) Show SMILES CC(C)Cc1nc(-c2ccc(CN3CCC(CC3)n3c4ccccc4[nH]c3=O)cc2)c([nH]c1=O)-c1ccccc1 Show InChI InChI=1S/C33H35N5O2/c1-22(2)20-28-32(39)36-31(24-8-4-3-5-9-24)30(34-28)25-14-12-23(13-15-25)21-37-18-16-26(17-19-37)38-29-11-7-6-10-27(29)35-33(38)40/h3-15,22,26H,16-21H2,1-2H3,(H,35,40)(H,36,39)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories					Assay Description Purified recombinant human Akt1, Akt2, and Akt3 proteins were monitored for kinase activity in the presence or absence of Akt inhibitors in a 96-well...				Bioorg Med Chem Lett 15: 761-4 (2005) Article DOI: 10.1016/j.bmcl.2004.11.011 BindingDB Entry DOI: 10.7270/Q2TX3CM4
					More data for this Ligand-Target Pair
RAC-gamma serine/threonine-protein kinase (Homo sapiens (Human))	BDBM15162 (2-(4-{[4-(2-oxo-2,3-dihydro-1H-1,3-benzodiazol-1-y...) Show SMILES OC(=O)c1ccc2nc(-c3ccc(CN4CCC(CC4)n4c5ccccc5[nH]c4=O)cc3)c(nc2c1)-c1ccccc1 Show InChI InChI=1S/C34H29N5O3/c40-33(41)25-14-15-27-29(20-25)36-31(23-6-2-1-3-7-23)32(35-27)24-12-10-22(11-13-24)21-38-18-16-26(17-19-38)39-30-9-5-4-8-28(30)37-34(39)42/h1-15,20,26H,16-19,21H2,(H,37,42)(H,40,41)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories					Assay Description Purified recombinant human Akt1, Akt2, and Akt3 proteins were monitored for kinase activity in the presence or absence of Akt inhibitors in a 96-well...				Bioorg Med Chem Lett 15: 761-4 (2005) Article DOI: 10.1016/j.bmcl.2004.11.011 BindingDB Entry DOI: 10.7270/Q2TX3CM4
					More data for this Ligand-Target Pair

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