Found 75 hits Enz. Inhib. hit(s) with all data for assayid = 3 entry = 50041115 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Dihydrofolate reductase
(Gallus gallus (Chicken)) | BDBM50405088
(CHEMBL31004)Show SMILES CC1(C)N=C(N)N=C(N)N1c1ccc(CSc2ccccc2)cc1 |t:3,6| Show InChI InChI=1S/C18H21N5S/c1-18(2)22-16(19)21-17(20)23(18)14-10-8-13(9-11-14)12-24-15-6-4-3-5-7-15/h3-11H,12H2,1-2H3,(H4,19,20,21,22) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 6.80 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibitory activity against isolated chicken liver dihydrofolate reductase (DHFR) |
J Med Chem 27: 129-43 (1984)
BindingDB Entry DOI: 10.7270/Q2TT4S5M |
More data for this
Ligand-Target Pair | |
Dihydrofolate reductase
(Gallus gallus (Chicken)) | BDBM50405055
(CHEMBL283173)Show SMILES CC1(C)N=C(N)N=C(N)N1c1ccc(SCc2ccccc2)cc1 |t:3,6| Show InChI InChI=1S/C18H21N5S/c1-18(2)22-16(19)21-17(20)23(18)14-8-10-15(11-9-14)24-12-13-6-4-3-5-7-13/h3-11H,12H2,1-2H3,(H4,19,20,21,22) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 19 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibitory activity against isolated chicken liver dihydrofolate reductase (DHFR) |
J Med Chem 27: 129-43 (1984)
BindingDB Entry DOI: 10.7270/Q2TT4S5M |
More data for this
Ligand-Target Pair | |
Dihydrofolate reductase
(Gallus gallus (Chicken)) | BDBM50291768
(6,6-Dimethyl-1-(3-phenylselanylmethyl-phenyl)-1,6-...)Show SMILES CC1(C)N=C(N)N=C(N)N1c1cccc(C[Se]c2ccccc2)c1 |t:3,6| Show InChI InChI=1S/C18H21N5Se/c1-18(2)22-16(19)21-17(20)23(18)14-8-6-7-13(11-14)12-24-15-9-4-3-5-10-15/h3-11H,12H2,1-2H3,(H4,19,20,21,22) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| PubMed
| 20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibitory activity against isolated chicken liver dihydrofolate reductase (DHFR) |
J Med Chem 27: 129-43 (1984)
BindingDB Entry DOI: 10.7270/Q2TT4S5M |
More data for this
Ligand-Target Pair | |
Dihydrofolate reductase
(Gallus gallus (Chicken)) | BDBM50291778
(CHEMBL20812 | N-{3-[3-(4,6-Diamino-2,2-dimethyl-2H...)Show SMILES CC(=O)Nc1cccc(OCc2cccc(c2)N2C(N)=NC(N)=NC2(C)C)c1 |c:20,23| Show InChI InChI=1S/C20H24N6O2/c1-13(27)23-15-7-5-9-17(11-15)28-12-14-6-4-8-16(10-14)26-19(22)24-18(21)25-20(26,2)3/h4-11H,12H2,1-3H3,(H,23,27)(H4,21,22,24,25) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 23 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibitory activity against isolated chicken liver dihydrofolate reductase (DHFR) |
J Med Chem 27: 129-43 (1984)
BindingDB Entry DOI: 10.7270/Q2TT4S5M |
More data for this
Ligand-Target Pair | |
Dihydrofolate reductase
(Gallus gallus (Chicken)) | BDBM50291782
(3-[3-(4,6-Diamino-2,2-dimethyl-2H-[1,3,5]triazin-1...)Show SMILES CC1(C)N=C(N)N=C(N)N1c1cccc(COc2cccc(c2)C#N)c1 |t:3,6| Show InChI InChI=1S/C19H20N6O/c1-19(2)24-17(21)23-18(22)25(19)15-7-3-6-14(9-15)12-26-16-8-4-5-13(10-16)11-20/h3-10H,12H2,1-2H3,(H4,21,22,23,24) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 26 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibitory activity against isolated chicken liver dihydrofolate reductase (DHFR) |
J Med Chem 27: 129-43 (1984)
BindingDB Entry DOI: 10.7270/Q2TT4S5M |
More data for this
Ligand-Target Pair | |
Dihydrofolate reductase
(Gallus gallus (Chicken)) | BDBM50291805
(6,6-Dimethyl-1-{3-[4-(3-trifluoromethyl-phenoxy)-b...)Show SMILES CC1(C)N=C(N)N=C(N)N1c1cccc(OCCCCOc2cccc(c2)C(F)(F)F)c1 |t:3,6| Show InChI InChI=1S/C22H26F3N5O2/c1-21(2)29-19(26)28-20(27)30(21)16-8-6-10-18(14-16)32-12-4-3-11-31-17-9-5-7-15(13-17)22(23,24)25/h5-10,13-14H,3-4,11-12H2,1-2H3,(H4,26,27,28,29) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 29 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibitory activity against isolated chicken liver dihydrofolate reductase (DHFR) |
J Med Chem 27: 129-43 (1984)
BindingDB Entry DOI: 10.7270/Q2TT4S5M |
More data for this
Ligand-Target Pair | |
Dihydrofolate reductase
(Gallus gallus (Chicken)) | BDBM50291804
(1-(3-Benzylsulfanyl-phenyl)-6,6-dimethyl-1,6-dihyd...)Show SMILES CC1(C)N=C(N)N=C(N)N1c1cccc(SCc2ccccc2)c1 |t:3,6| Show InChI InChI=1S/C18H21N5S/c1-18(2)22-16(19)21-17(20)23(18)14-9-6-10-15(11-14)24-12-13-7-4-3-5-8-13/h3-11H,12H2,1-2H3,(H4,19,20,21,22) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibitory activity against isolated chicken liver dihydrofolate reductase (DHFR) |
J Med Chem 27: 129-43 (1984)
BindingDB Entry DOI: 10.7270/Q2TT4S5M |
More data for this
Ligand-Target Pair | |
Dihydrofolate reductase
(Gallus gallus (Chicken)) | BDBM50405043
(1-(4-(Benzyloxy)phenyl)-6,6-dimethyl-1,6-dihydro-1...)Show SMILES CC1(C)N=C(N)N=C(N)N1c1ccc(OCc2ccccc2)cc1 |t:3,6| Show InChI InChI=1S/C18H21N5O/c1-18(2)22-16(19)21-17(20)23(18)14-8-10-15(11-9-14)24-12-13-6-4-3-5-7-13/h3-11H,12H2,1-2H3,(H4,19,20,21,22) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibitory activity against isolated chicken liver dihydrofolate reductase (DHFR) |
J Med Chem 27: 129-43 (1984)
BindingDB Entry DOI: 10.7270/Q2TT4S5M |
More data for this
Ligand-Target Pair | |
Dihydrofolate reductase
(Gallus gallus (Chicken)) | BDBM50405070
(CHEMBL30681)Show SMILES CC1(C)N=C(N)N=C(N)N1c1ccc(OCc2ccc(cc2)S(N)(=O)=O)cc1 |t:3,6| Show InChI InChI=1S/C18H22N6O3S/c1-18(2)23-16(19)22-17(20)24(18)13-5-7-14(8-6-13)27-11-12-3-9-15(10-4-12)28(21,25)26/h3-10H,11H2,1-2H3,(H2,21,25,26)(H4,19,20,22,23) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| PubMed
| 32 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibitory activity against isolated chicken liver dihydrofolate reductase (DHFR) |
J Med Chem 27: 129-43 (1984)
BindingDB Entry DOI: 10.7270/Q2TT4S5M |
More data for this
Ligand-Target Pair | |
Dihydrofolate reductase
(Gallus gallus (Chicken)) | BDBM50291794
(6,6-Dimethyl-1-(3-phenylsulfanylmethyl-phenyl)-1,6...)Show SMILES CC1(C)N=C(N)N=C(N)N1c1cccc(CSc2ccccc2)c1 |t:3,6| Show InChI InChI=1S/C18H21N5S/c1-18(2)22-16(19)21-17(20)23(18)14-8-6-7-13(11-14)12-24-15-9-4-3-5-10-15/h3-11H,12H2,1-2H3,(H4,19,20,21,22) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 34 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibitory activity against isolated chicken liver dihydrofolate reductase (DHFR) |
J Med Chem 27: 129-43 (1984)
BindingDB Entry DOI: 10.7270/Q2TT4S5M |
More data for this
Ligand-Target Pair | |
Dihydrofolate reductase
(Gallus gallus (Chicken)) | BDBM50405089
(CHEMBL268414)Show InChI InChI=1S/C11H14IN5/c1-11(2)16-9(13)15-10(14)17(11)8-5-3-4-7(12)6-8/h3-6H,1-2H3,(H4,13,14,15,16) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 36 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibitory activity against isolated chicken liver dihydrofolate reductase (DHFR) |
J Med Chem 27: 129-43 (1984)
BindingDB Entry DOI: 10.7270/Q2TT4S5M |
More data for this
Ligand-Target Pair | |
Dihydrofolate reductase
(Gallus gallus (Chicken)) | BDBM50405052
(CHEMBL283916)Show SMILES Cc1cccc(SCc2ccc(cc2)N2C(N)=NC(N)=NC2(C)C)c1 |c:17,20| Show InChI InChI=1S/C19H23N5S/c1-13-5-4-6-16(11-13)25-12-14-7-9-15(10-8-14)24-18(21)22-17(20)23-19(24,2)3/h4-11H,12H2,1-3H3,(H4,20,21,22,23) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibitory activity against isolated chicken liver dihydrofolate reductase (DHFR) |
J Med Chem 27: 129-43 (1984)
BindingDB Entry DOI: 10.7270/Q2TT4S5M |
More data for this
Ligand-Target Pair | |
Dihydrofolate reductase
(Gallus gallus (Chicken)) | BDBM50405046
(CHEMBL6962)Show SMILES CCCCc1ccc(cc1)N1C(N)=NC(N)=NC1(C)C |c:13,16| Show InChI InChI=1S/C15H23N5/c1-4-5-6-11-7-9-12(10-8-11)20-14(17)18-13(16)19-15(20,2)3/h7-10H,4-6H2,1-3H3,(H4,16,17,18,19) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 42 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibitory activity against isolated chicken liver dihydrofolate reductase (DHFR) |
J Med Chem 27: 129-43 (1984)
BindingDB Entry DOI: 10.7270/Q2TT4S5M |
More data for this
Ligand-Target Pair | |
Dihydrofolate reductase
(Gallus gallus (Chicken)) | BDBM50405074
(CHEMBL34627)Show SMILES CC1(C)N=C(N)N=C(N)N1c1ccc(OCc2ccc(cc2)C(N)=O)cc1 |t:3,6| Show InChI InChI=1S/C19H22N6O2/c1-19(2)24-17(21)23-18(22)25(19)14-7-9-15(10-8-14)27-11-12-3-5-13(6-4-12)16(20)26/h3-10H,11H2,1-2H3,(H2,20,26)(H4,21,22,23,24) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 50 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibitory activity against isolated chicken liver dihydrofolate reductase (DHFR) |
J Med Chem 27: 129-43 (1984)
BindingDB Entry DOI: 10.7270/Q2TT4S5M |
More data for this
Ligand-Target Pair | |
Dihydrofolate reductase
(Gallus gallus (Chicken)) | BDBM50405042
(CHEMBL282754)Show SMILES CC1(C)N=C(N)N=C(N)N1c1cccc(COc2ccccc2)c1 |t:3,6| Show InChI InChI=1S/C18H21N5O/c1-18(2)22-16(19)21-17(20)23(18)14-8-6-7-13(11-14)12-24-15-9-4-3-5-10-15/h3-11H,12H2,1-2H3,(H4,19,20,21,22) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 52 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibitory activity against isolated chicken liver dihydrofolate reductase (DHFR) |
J Med Chem 27: 129-43 (1984)
BindingDB Entry DOI: 10.7270/Q2TT4S5M |
More data for this
Ligand-Target Pair | |
Dihydrofolate reductase
(Gallus gallus (Chicken)) | BDBM50291802
(1-[3-(3-Ethyl-phenoxymethyl)-phenyl]-6,6-dimethyl-...)Show SMILES CCc1cccc(OCc2cccc(c2)N2C(N)=NC(N)=NC2(C)C)c1 |c:18,21| Show InChI InChI=1S/C20H25N5O/c1-4-14-7-6-10-17(12-14)26-13-15-8-5-9-16(11-15)25-19(22)23-18(21)24-20(25,2)3/h5-12H,4,13H2,1-3H3,(H4,21,22,23,24) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 54 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibitory activity against isolated chicken liver dihydrofolate reductase (DHFR) |
J Med Chem 27: 129-43 (1984)
BindingDB Entry DOI: 10.7270/Q2TT4S5M |
More data for this
Ligand-Target Pair | |
Dihydrofolate reductase
(Gallus gallus (Chicken)) | BDBM50405037
(CHEMBL33558)Show SMILES CC(C)(C)c1cccc(OCc2cccc(c2)N2C(N)=NC(N)=NC2(C)C)c1 |c:20,23| Show InChI InChI=1S/C22H29N5O/c1-21(2,3)16-9-7-11-18(13-16)28-14-15-8-6-10-17(12-15)27-20(24)25-19(23)26-22(27,4)5/h6-13H,14H2,1-5H3,(H4,23,24,25,26) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 58 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibitory activity against isolated chicken liver dihydrofolate reductase (DHFR) |
J Med Chem 27: 129-43 (1984)
BindingDB Entry DOI: 10.7270/Q2TT4S5M |
More data for this
Ligand-Target Pair | |
Dihydrofolate reductase
(Gallus gallus (Chicken)) | BDBM50405068
(CHEMBL34274)Show SMILES CC1(C)N=C(N)N=C(N)N1c1cccc(COC2CCCCC2)c1 |t:3,6| Show InChI InChI=1S/C18H27N5O/c1-18(2)22-16(19)21-17(20)23(18)14-8-6-7-13(11-14)12-24-15-9-4-3-5-10-15/h6-8,11,15H,3-5,9-10,12H2,1-2H3,(H4,19,20,21,22) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| PubMed
| 65 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibitory activity against isolated chicken liver dihydrofolate reductase (DHFR) |
J Med Chem 27: 129-43 (1984)
BindingDB Entry DOI: 10.7270/Q2TT4S5M |
More data for this
Ligand-Target Pair | |
Dihydrofolate reductase
(Gallus gallus (Chicken)) | BDBM50291792
(4-[3-(4,6-Diamino-2,2-dimethyl-2H-[1,3,5]triazin-1...)Show SMILES CC1(C)N=C(N)N=C(N)N1c1cccc(CNc2ccc(cc2)S(N)(=O)=O)c1 |t:3,6| Show InChI InChI=1S/C18H23N7O2S/c1-18(2)24-16(19)23-17(20)25(18)14-5-3-4-12(10-14)11-22-13-6-8-15(9-7-13)28(21,26)27/h3-10,22H,11H2,1-2H3,(H2,21,26,27)(H4,19,20,23,24) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 66 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibitory activity against isolated chicken liver dihydrofolate reductase (DHFR) |
J Med Chem 27: 129-43 (1984)
BindingDB Entry DOI: 10.7270/Q2TT4S5M |
More data for this
Ligand-Target Pair | |
Dihydrofolate reductase
(Gallus gallus (Chicken)) | BDBM50405054
(CHEMBL7035)Show SMILES CC1(C)N=C(N)N=C(N)N1c1ccc(OCc2ccc(Cl)c(Cl)c2)cc1 |t:3,6| Show InChI InChI=1S/C18H19Cl2N5O/c1-18(2)24-16(21)23-17(22)25(18)12-4-6-13(7-5-12)26-10-11-3-8-14(19)15(20)9-11/h3-9H,10H2,1-2H3,(H4,21,22,23,24) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 72 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibitory activity against isolated chicken liver dihydrofolate reductase (DHFR) |
J Med Chem 27: 129-43 (1984)
BindingDB Entry DOI: 10.7270/Q2TT4S5M |
More data for this
Ligand-Target Pair | |
Dihydrofolate reductase
(Gallus gallus (Chicken)) | BDBM50405049
(CHEMBL285019)Show SMILES CC1(C)N=C(N)N=C(N)N1c1ccc(SCc2ccc(Cl)cc2)cc1 |t:3,6| Show InChI InChI=1S/C18H20ClN5S/c1-18(2)23-16(20)22-17(21)24(18)14-7-9-15(10-8-14)25-11-12-3-5-13(19)6-4-12/h3-10H,11H2,1-2H3,(H4,20,21,22,23) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 74 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibitory activity against isolated chicken liver dihydrofolate reductase (DHFR) |
J Med Chem 27: 129-43 (1984)
BindingDB Entry DOI: 10.7270/Q2TT4S5M |
More data for this
Ligand-Target Pair | |
Dihydrofolate reductase
(Gallus gallus (Chicken)) | BDBM50090075
(1-(4-Bromo-phenyl)-6,6-dimethyl-1,6-dihydro-[1,3,5...)Show InChI InChI=1S/C11H14BrN5/c1-11(2)16-9(13)15-10(14)17(11)8-5-3-7(12)4-6-8/h3-6H,1-2H3,(H4,13,14,15,16) | PDB
Reactome pathway
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| 76 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibitory activity against isolated chicken liver dihydrofolate reductase (DHFR) |
J Med Chem 27: 129-43 (1984)
BindingDB Entry DOI: 10.7270/Q2TT4S5M |
More data for this
Ligand-Target Pair | |
Dihydrofolate reductase
(Gallus gallus (Chicken)) | BDBM50405067
(CHEMBL32063)Show SMILES CCCCCCc1cccc(c1)N1C(N)=NC(N)=NC1(C)C |c:15,18| Show InChI InChI=1S/C17H27N5/c1-4-5-6-7-9-13-10-8-11-14(12-13)22-16(19)20-15(18)21-17(22,2)3/h8,10-12H,4-7,9H2,1-3H3,(H4,18,19,20,21) | PDB
Reactome pathway
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| 76 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibitory activity against isolated chicken liver dihydrofolate reductase (DHFR) |
J Med Chem 27: 129-43 (1984)
BindingDB Entry DOI: 10.7270/Q2TT4S5M |
More data for this
Ligand-Target Pair | |
Dihydrofolate reductase
(Gallus gallus (Chicken)) | BDBM50090051
(6,6-Dimethyl-1-p-tolyl-1,6-dihydro-[1,3,5]triazine...)Show InChI InChI=1S/C12H17N5/c1-8-4-6-9(7-5-8)17-11(14)15-10(13)16-12(17,2)3/h4-7H,1-3H3,(H4,13,14,15,16) | PDB
Reactome pathway
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| 81 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibitory activity against isolated chicken liver dihydrofolate reductase (DHFR) |
J Med Chem 27: 129-43 (1984)
BindingDB Entry DOI: 10.7270/Q2TT4S5M |
More data for this
Ligand-Target Pair | |
Dihydrofolate reductase
(Gallus gallus (Chicken)) | BDBM50405059
(CHEMBL7070)Show InChI InChI=1S/C12H17N5/c1-8-5-4-6-9(7-8)17-11(14)15-10(13)16-12(17,2)3/h4-7H,1-3H3,(H4,13,14,15,16) | PDB
Reactome pathway
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| 83 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibitory activity against isolated chicken liver dihydrofolate reductase (DHFR) |
J Med Chem 27: 129-43 (1984)
BindingDB Entry DOI: 10.7270/Q2TT4S5M |
More data for this
Ligand-Target Pair | |
Dihydrofolate reductase
(Gallus gallus (Chicken)) | BDBM50405090
(CHEMBL287436)Show SMILES CC1(C)N=C(N)N=C(N)N1c1cccc(OCc2ccc(cc2)C(N)=O)c1 |t:3,6| Show InChI InChI=1S/C19H22N6O2/c1-19(2)24-17(21)23-18(22)25(19)14-4-3-5-15(10-14)27-11-12-6-8-13(9-7-12)16(20)26/h3-10H,11H2,1-2H3,(H2,20,26)(H4,21,22,23,24) | PDB
Reactome pathway
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| 89 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibitory activity against isolated chicken liver dihydrofolate reductase (DHFR) |
J Med Chem 27: 129-43 (1984)
BindingDB Entry DOI: 10.7270/Q2TT4S5M |
More data for this
Ligand-Target Pair | |
Dihydrofolate reductase
(Gallus gallus (Chicken)) | BDBM50291793
(6,6-Dimethyl-1-(3-trifluoromethyl-phenyl)-1,6-dihy...)Show SMILES CC1(C)N=C(N)N=C(N)N1c1cccc(c1)C(F)(F)F |t:3,6| Show InChI InChI=1S/C12H14F3N5/c1-11(2)19-9(16)18-10(17)20(11)8-5-3-4-7(6-8)12(13,14)15/h3-6H,1-2H3,(H4,16,17,18,19) | PDB
Reactome pathway
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| 98 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibitory activity against isolated chicken liver dihydrofolate reductase (DHFR) |
J Med Chem 27: 129-43 (1984)
BindingDB Entry DOI: 10.7270/Q2TT4S5M |
More data for this
Ligand-Target Pair | |
Dihydrofolate reductase
(Gallus gallus (Chicken)) | BDBM50291767
(1-(3-Ethyl-phenyl)-6,6-dimethyl-1,6-dihydro-[1,3,5...)Show InChI InChI=1S/C13H19N5/c1-4-9-6-5-7-10(8-9)18-12(15)16-11(14)17-13(18,2)3/h5-8H,4H2,1-3H3,(H4,14,15,16,17) | PDB
Reactome pathway
KEGG
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| PubMed
| 100 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibitory activity against isolated chicken liver dihydrofolate reductase (DHFR) |
J Med Chem 27: 129-43 (1984)
BindingDB Entry DOI: 10.7270/Q2TT4S5M |
More data for this
Ligand-Target Pair | |
Dihydrofolate reductase
(Gallus gallus (Chicken)) | BDBM50291781
(5-[3-(4,6-Diamino-2,2-dimethyl-2H-[1,3,5]triazin-1...)Show SMILES CC1(C)N=C(N)N=C(N)N1c1cccc(CNc2cc(cc(c2)C(N)=O)C(N)=O)c1 |t:3,6| Show InChI InChI=1S/C20H24N8O2/c1-20(2)27-18(23)26-19(24)28(20)15-5-3-4-11(6-15)10-25-14-8-12(16(21)29)7-13(9-14)17(22)30/h3-9,25H,10H2,1-2H3,(H2,21,29)(H2,22,30)(H4,23,24,26,27) | PDB
Reactome pathway
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| 105 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibitory activity against isolated chicken liver dihydrofolate reductase (DHFR) |
J Med Chem 27: 129-43 (1984)
BindingDB Entry DOI: 10.7270/Q2TT4S5M |
More data for this
Ligand-Target Pair | |
Dihydrofolate reductase
(Gallus gallus (Chicken)) | BDBM18792
(1-(4-chlorophenyl)-6,6-dimethyl-1,6-dihydro-1,3,5-...)Show InChI InChI=1S/C11H14ClN5/c1-11(2)16-9(13)15-10(14)17(11)8-5-3-7(12)4-6-8/h3-6H,1-2H3,(H4,13,14,15,16) | PDB
Reactome pathway
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PDB
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| 112 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibitory activity against isolated chicken liver dihydrofolate reductase (DHFR) |
J Med Chem 27: 129-43 (1984)
BindingDB Entry DOI: 10.7270/Q2TT4S5M |
More data for this
Ligand-Target Pair | |
Dihydrofolate reductase
(Gallus gallus (Chicken)) | BDBM50291774
(6,6-Dimethyl-1-(3-nitro-phenyl)-1,6-dihydro-[1,3,5...)Show SMILES CC1(C)N=C(N)N=C(N)N1c1cccc(c1)[N+]([O-])=O |t:3,6| Show InChI InChI=1S/C11H14N6O2/c1-11(2)15-9(12)14-10(13)16(11)7-4-3-5-8(6-7)17(18)19/h3-6H,1-2H3,(H4,12,13,14,15) | PDB
Reactome pathway
KEGG
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| PubMed
| 112 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibitory activity against isolated chicken liver dihydrofolate reductase (DHFR) |
J Med Chem 27: 129-43 (1984)
BindingDB Entry DOI: 10.7270/Q2TT4S5M |
More data for this
Ligand-Target Pair | |
Dihydrofolate reductase
(Gallus gallus (Chicken)) | BDBM50291779
(3-(4,6-Diamino-2,2-dimethyl-2H-[1,3,5]triazin-1-yl...)Show InChI InChI=1S/C12H14N6/c1-12(2)17-10(14)16-11(15)18(12)9-5-3-4-8(6-9)7-13/h3-6H,1-2H3,(H4,14,15,16,17) | PDB
Reactome pathway
KEGG
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| 115 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibitory activity against isolated chicken liver dihydrofolate reductase (DHFR) |
J Med Chem 27: 129-43 (1984)
BindingDB Entry DOI: 10.7270/Q2TT4S5M |
More data for this
Ligand-Target Pair | |
Dihydrofolate reductase
(Gallus gallus (Chicken)) | BDBM50405048
(CHEMBL7341)Show InChI InChI=1S/C11H14IN5/c1-11(2)16-9(13)15-10(14)17(11)8-5-3-7(12)4-6-8/h3-6H,1-2H3,(H4,13,14,15,16) | PDB
Reactome pathway
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| 117 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibitory activity against isolated chicken liver dihydrofolate reductase (DHFR) |
J Med Chem 27: 129-43 (1984)
BindingDB Entry DOI: 10.7270/Q2TT4S5M |
More data for this
Ligand-Target Pair | |
Dihydrofolate reductase
(Gallus gallus (Chicken)) | BDBM50291780
(1-(3-Benzyloxy-phenyl)-6,6-dimethyl-1,6-dihydro-[1...)Show SMILES CC1(C)N=C(N)N=C(N)N1c1cccc(OCc2ccccc2)c1 |t:3,6| Show InChI InChI=1S/C18H21N5O/c1-18(2)22-16(19)21-17(20)23(18)14-9-6-10-15(11-14)24-12-13-7-4-3-5-8-13/h3-11H,12H2,1-2H3,(H4,19,20,21,22) | PDB
Reactome pathway
KEGG
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| 117 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibitory activity against isolated chicken liver dihydrofolate reductase (DHFR) |
J Med Chem 27: 129-43 (1984)
BindingDB Entry DOI: 10.7270/Q2TT4S5M |
More data for this
Ligand-Target Pair | |
Dihydrofolate reductase
(Gallus gallus (Chicken)) | BDBM50090050
(1-(4-Fluoro-phenyl)-6,6-dimethyl-1,6-dihydro-[1,3,...)Show InChI InChI=1S/C11H14FN5/c1-11(2)16-9(13)15-10(14)17(11)8-5-3-7(12)4-6-8/h3-6H,1-2H3,(H4,13,14,15,16) | PDB
Reactome pathway
KEGG
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Similars
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| 129 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibitory activity against isolated chicken liver dihydrofolate reductase (DHFR) |
J Med Chem 27: 129-43 (1984)
BindingDB Entry DOI: 10.7270/Q2TT4S5M |
More data for this
Ligand-Target Pair | |
Dihydrofolate reductase
(Gallus gallus (Chicken)) | BDBM50291790
(1-[3-(Biphenyl-3-yloxymethyl)-phenyl]-6,6-dimethyl...)Show SMILES CC1(C)N=C(N)N=C(N)N1c1cccc(COc2cccc(c2)-c2ccccc2)c1 |t:3,6| Show InChI InChI=1S/C24H25N5O/c1-24(2)28-22(25)27-23(26)29(24)20-12-6-8-17(14-20)16-30-21-13-7-11-19(15-21)18-9-4-3-5-10-18/h3-15H,16H2,1-2H3,(H4,25,26,27,28) | PDB
Reactome pathway
KEGG
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UniChem
Similars
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| 162 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibitory activity against isolated chicken liver dihydrofolate reductase (DHFR) |
J Med Chem 27: 129-43 (1984)
BindingDB Entry DOI: 10.7270/Q2TT4S5M |
More data for this
Ligand-Target Pair | |
Dihydrofolate reductase
(Gallus gallus (Chicken)) | BDBM50405083
(CHEMBL267499)Show InChI InChI=1S/C11H14FN5/c1-11(2)16-9(13)15-10(14)17(11)8-5-3-4-7(12)6-8/h3-6H,1-2H3,(H4,13,14,15,16) | PDB
Reactome pathway
KEGG
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Similars
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| 162 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibitory activity against isolated chicken liver dihydrofolate reductase (DHFR) |
J Med Chem 27: 129-43 (1984)
BindingDB Entry DOI: 10.7270/Q2TT4S5M |
More data for this
Ligand-Target Pair | |
Dihydrofolate reductase
(Gallus gallus (Chicken)) | BDBM50405076
(CHEMBL269704)Show SMILES CC1(C)N=C(N)N=C(N)N1c1cccc(OCc2ccc(Cl)c(Cl)c2)c1 |t:3,6| Show InChI InChI=1S/C18H19Cl2N5O/c1-18(2)24-16(21)23-17(22)25(18)12-4-3-5-13(9-12)26-10-11-6-7-14(19)15(20)8-11/h3-9H,10H2,1-2H3,(H4,21,22,23,24) | PDB
Reactome pathway
KEGG
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| 166 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibitory activity against isolated chicken liver dihydrofolate reductase (DHFR) |
J Med Chem 27: 129-43 (1984)
BindingDB Entry DOI: 10.7270/Q2TT4S5M |
More data for this
Ligand-Target Pair | |
Dihydrofolate reductase
(Gallus gallus (Chicken)) | BDBM50405063
(CHEMBL427826)Show SMILES CC1(C)N=C(N)N=C(N)N1c1ccc(cc1)C(F)(F)F |t:3,6| Show InChI InChI=1S/C12H14F3N5/c1-11(2)19-9(16)18-10(17)20(11)8-5-3-7(4-6-8)12(13,14)15/h3-6H,1-2H3,(H4,16,17,18,19) | PDB
Reactome pathway
KEGG
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UniChem
Similars
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| 170 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibitory activity against isolated chicken liver dihydrofolate reductase (DHFR) |
J Med Chem 27: 129-43 (1984)
BindingDB Entry DOI: 10.7270/Q2TT4S5M |
More data for this
Ligand-Target Pair | |
Dihydrofolate reductase
(Gallus gallus (Chicken)) | BDBM50405098
(CHEMBL30370)Show SMILES CC1(C)N=C(N)N=C(N)N1c1ccc(OCC(=O)N2CCOCC2)cc1 |t:3,6| Show InChI InChI=1S/C17H24N6O3/c1-17(2)21-15(18)20-16(19)23(17)12-3-5-13(6-4-12)26-11-14(24)22-7-9-25-10-8-22/h3-6H,7-11H2,1-2H3,(H4,18,19,20,21) | PDB
Reactome pathway
KEGG
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UniChem
| PubMed
| 170 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibitory activity against isolated chicken liver dihydrofolate reductase (DHFR) |
J Med Chem 27: 129-43 (1984)
BindingDB Entry DOI: 10.7270/Q2TT4S5M |
More data for this
Ligand-Target Pair | |
Dihydrofolate reductase
(Gallus gallus (Chicken)) | BDBM50405051
(CHEMBL33389)Show SMILES CC1(C)N=C(N)N=C(N)N1c1ccc(OCCOc2ccc(N)cc2)cc1 |t:3,6| Show InChI InChI=1S/C19H24N6O2/c1-19(2)24-17(21)23-18(22)25(19)14-5-9-16(10-6-14)27-12-11-26-15-7-3-13(20)4-8-15/h3-10H,11-12,20H2,1-2H3,(H4,21,22,23,24) | PDB
Reactome pathway
KEGG
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UniChem
Similars
| PubMed
| 174 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibitory activity against isolated chicken liver dihydrofolate reductase (DHFR) |
J Med Chem 27: 129-43 (1984)
BindingDB Entry DOI: 10.7270/Q2TT4S5M |
More data for this
Ligand-Target Pair | |
Dihydrofolate reductase
(Gallus gallus (Chicken)) | BDBM50291798
(1-(3-tert-Butyl-phenyl)-6,6-dimethyl-1,6-dihydro-[...)Show SMILES CC(C)(C)c1cccc(c1)N1C(N)=NC(N)=NC1(C)C |c:13,16| Show InChI InChI=1S/C15H23N5/c1-14(2,3)10-7-6-8-11(9-10)20-13(17)18-12(16)19-15(20,4)5/h6-9H,1-5H3,(H4,16,17,18,19) | PDB
Reactome pathway
KEGG
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PC sid
UniChem
Similars
| PubMed
| 178 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibitory activity against isolated chicken liver dihydrofolate reductase (DHFR) |
J Med Chem 27: 129-43 (1984)
BindingDB Entry DOI: 10.7270/Q2TT4S5M |
More data for this
Ligand-Target Pair | |
Dihydrofolate reductase
(Gallus gallus (Chicken)) | BDBM50405057
(CHEMBL6661)Show SMILES CC(C)(C)c1ccc(cc1)N1C(N)=NC(N)=NC1(C)C |c:13,16| Show InChI InChI=1S/C15H23N5/c1-14(2,3)10-6-8-11(9-7-10)20-13(17)18-12(16)19-15(20,4)5/h6-9H,1-5H3,(H4,16,17,18,19) | PDB
Reactome pathway
KEGG
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| CHEMBL
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PC sid
UniChem
Similars
| PubMed
| 195 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibitory activity against isolated chicken liver dihydrofolate reductase (DHFR) |
J Med Chem 27: 129-43 (1984)
BindingDB Entry DOI: 10.7270/Q2TT4S5M |
More data for this
Ligand-Target Pair | |
Dihydrofolate reductase
(Gallus gallus (Chicken)) | BDBM50291787
(6,6-Dimethyl-1-[3-(4-pentyl-phenoxymethyl)-phenyl]...)Show SMILES CCCCCc1ccc(OCc2cccc(c2)N2C(N)=NC(N)=NC2(C)C)cc1 |c:20,23| Show InChI InChI=1S/C23H31N5O/c1-4-5-6-8-17-11-13-20(14-12-17)29-16-18-9-7-10-19(15-18)28-22(25)26-21(24)27-23(28,2)3/h7,9-15H,4-6,8,16H2,1-3H3,(H4,24,25,26,27) | PDB
Reactome pathway
KEGG
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Similars
| PubMed
| 195 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibitory activity against isolated chicken liver dihydrofolate reductase (DHFR) |
J Med Chem 27: 129-43 (1984)
BindingDB Entry DOI: 10.7270/Q2TT4S5M |
More data for this
Ligand-Target Pair | |
Dihydrofolate reductase
(Gallus gallus (Chicken)) | BDBM50090067
(6,6-Dimethyl-1-phenyl-1,6-dihydro-[1,3,5]triazine-...)Show InChI InChI=1S/C11H15N5/c1-11(2)15-9(12)14-10(13)16(11)8-6-4-3-5-7-8/h3-7H,1-2H3,(H4,12,13,14,15) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
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| Purchase
CHEMBL
MCE
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| 204 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibitory activity against isolated chicken liver dihydrofolate reductase (DHFR) |
J Med Chem 27: 129-43 (1984)
BindingDB Entry DOI: 10.7270/Q2TT4S5M |
More data for this
Ligand-Target Pair | |
Dihydrofolate reductase
(Gallus gallus (Chicken)) | BDBM50291784
(6,6-Dimethyl-1-(3-nonyloxy-phenyl)-1,6-dihydro-[1,...)Show SMILES CCCCCCCCCOc1cccc(c1)N1C(N)=NC(N)=NC1(C)C |c:19,22| Show InChI InChI=1S/C20H33N5O/c1-4-5-6-7-8-9-10-14-26-17-13-11-12-16(15-17)25-19(22)23-18(21)24-20(25,2)3/h11-13,15H,4-10,14H2,1-3H3,(H4,21,22,23,24) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 282 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibitory activity against isolated chicken liver dihydrofolate reductase (DHFR) |
J Med Chem 27: 129-43 (1984)
BindingDB Entry DOI: 10.7270/Q2TT4S5M |
More data for this
Ligand-Target Pair | |
Dihydrofolate reductase
(Gallus gallus (Chicken)) | BDBM50291769
(6,6-Dimethyl-1-(3-nonyl-phenyl)-1,6-dihydro-[1,3,5...)Show SMILES CCCCCCCCCc1cccc(c1)N1C(N)=NC(N)=NC1(C)C |c:18,21| Show InChI InChI=1S/C20H33N5/c1-4-5-6-7-8-9-10-12-16-13-11-14-17(15-16)25-19(22)23-18(21)24-20(25,2)3/h11,13-15H,4-10,12H2,1-3H3,(H4,21,22,23,24) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 295 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibitory activity against isolated chicken liver dihydrofolate reductase (DHFR) |
J Med Chem 27: 129-43 (1984)
BindingDB Entry DOI: 10.7270/Q2TT4S5M |
More data for this
Ligand-Target Pair | |
Dihydrofolate reductase
(Gallus gallus (Chicken)) | BDBM50291801
(6,6-Dimethyl-1-(3-tetradecyloxy-phenyl)-1,6-dihydr...)Show SMILES CCCCCCCCCCCCCCOc1cccc(c1)N1C(N)=NC(N)=NC1(C)C |c:24,27| Show InChI InChI=1S/C25H43N5O/c1-4-5-6-7-8-9-10-11-12-13-14-15-19-31-22-18-16-17-21(20-22)30-24(27)28-23(26)29-25(30,2)3/h16-18,20H,4-15,19H2,1-3H3,(H4,26,27,28,29) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 316 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibitory activity against isolated chicken liver dihydrofolate reductase (DHFR) |
J Med Chem 27: 129-43 (1984)
BindingDB Entry DOI: 10.7270/Q2TT4S5M |
More data for this
Ligand-Target Pair | |
Dihydrofolate reductase
(Gallus gallus (Chicken)) | BDBM50405100
(CHEMBL32304)Show SMILES CCCCCCCCCCCCOc1ccc(cc1)N1C(N)=NC(N)=NC1(C)C |c:22,25| Show InChI InChI=1S/C23H39N5O/c1-4-5-6-7-8-9-10-11-12-13-18-29-20-16-14-19(15-17-20)28-22(25)26-21(24)27-23(28,2)3/h14-17H,4-13,18H2,1-3H3,(H4,24,25,26,27) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 316 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibitory activity against isolated chicken liver dihydrofolate reductase (DHFR) |
J Med Chem 27: 129-43 (1984)
BindingDB Entry DOI: 10.7270/Q2TT4S5M |
More data for this
Ligand-Target Pair | |
Dihydrofolate reductase
(Gallus gallus (Chicken)) | BDBM50405035
(CHEMBL266573)Show InChI InChI=1S/C12H17N5O/c1-12(2)16-10(13)15-11(14)17(12)8-4-6-9(18-3)7-5-8/h4-7H,1-3H3,(H4,13,14,15,16) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 331 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibitory activity against isolated chicken liver dihydrofolate reductase (DHFR) |
J Med Chem 27: 129-43 (1984)
BindingDB Entry DOI: 10.7270/Q2TT4S5M |
More data for this
Ligand-Target Pair | |
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