Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Runt-related transcription factor 1 (Homo sapiens (Human)) | BDBM31183 (thiazol-2-amine, 14) | PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 700 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Virginia at Charlottesville | Assay Description His6-CBFbeta (1-141) was expressed and purified with the exception of the protease cleavage step. Cerulean-Runt domain fusion protein (Runx1 41-190) ... | Chem Biol 14: 1186-97 (2007) Article DOI: 10.1016/j.chembiol.2007.09.006 BindingDB Entry DOI: 10.7270/Q2862DTN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Runt-related transcription factor 1 (Homo sapiens (Human)) | BDBM29675 (2-methyl-N-(4-thiazolo[5,4-b]pyridin-2-ylphenyl)-1...) | PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Similars | PCBioAssay | n/a | n/a | 713 | n/a | n/a | n/a | n/a | 7.4 | 23 |
Burnham Center for Chemical Genomics Curated by PubChem BioAssay | Assay Description This assay is to identify inhibitors of the protein-protein interaction between the RUNX1 Runt domain and CBFbeta-SMMHC. This is accomplished by usin... | PubChem Bioassay (2009) BindingDB Entry DOI: 10.7270/Q25D8Q6Q | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Runt-related transcription factor 1 (Homo sapiens (Human)) | BDBM31183 (thiazol-2-amine, 14) | PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 1.10E+3 | n/a | n/a | n/a | n/a | 7.5 | 23 |
University of Virginia at Charlottesville | Assay Description For the FRET measurements, the Cerulean-Runt (Runx1 41-190) and Venus-CBFbeta (1-141) fusion proteins were dialyzed into FRET assay buffer. Protein c... | Chem Biol 14: 1186-97 (2007) Article DOI: 10.1016/j.chembiol.2007.09.006 BindingDB Entry DOI: 10.7270/Q2862DTN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Runt-related transcription factor 1 (Homo sapiens (Human)) | BDBM434071 (US10562890, Compound Al-12-16) | PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.69E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
UNIVERSITY OF VIRGINIA PATENT FOUNDATION US Patent | Assay Description FRET assay can be used to effectively monitor the inhibition of CBF binding to the Runt domain of RUNX proteins (as well as for CBFβ-SMMHC bindi... | US Patent US10562890 (2020) BindingDB Entry DOI: 10.7270/Q2DR2XWH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Runt-related transcription factor 1 (Homo sapiens (Human)) | BDBM434079 (US10562890, Compound Al-14-72) | PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.72E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
UNIVERSITY OF VIRGINIA PATENT FOUNDATION US Patent | Assay Description FRET assay can be used to effectively monitor the inhibition of CBF binding to the Runt domain of RUNX proteins (as well as for CBFβ-SMMHC bindi... | US Patent US10562890 (2020) BindingDB Entry DOI: 10.7270/Q2DR2XWH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Runt-related transcription factor 1 (Homo sapiens (Human)) | BDBM29652 (5-chloranyl-N-[4-([1,3]thiazolo[5,4-b]pyridin-2-yl...) | PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Similars | PCBioAssay | n/a | n/a | 1.87E+3 | n/a | n/a | n/a | n/a | 7.4 | 23 |
Burnham Center for Chemical Genomics Curated by PubChem BioAssay | Assay Description This assay is to identify inhibitors of the protein-protein interaction between the RUNX1 Runt domain and CBFbeta-SMMHC. This is accomplished by usin... | PubChem Bioassay (2009) BindingDB Entry DOI: 10.7270/Q25D8Q6Q | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Runt-related transcription factor 1 (Homo sapiens (Human)) | BDBM434076 (US10562890, Compound Al-14-100) | PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 2.16E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
UNIVERSITY OF VIRGINIA PATENT FOUNDATION US Patent | Assay Description FRET assay can be used to effectively monitor the inhibition of CBF binding to the Runt domain of RUNX proteins (as well as for CBFβ-SMMHC bindi... | US Patent US10562890 (2020) BindingDB Entry DOI: 10.7270/Q2DR2XWH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Runt-related transcription factor 1 (Homo sapiens (Human)) | BDBM434075 (US10562890, Compound Al-14-95) | PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 2.65E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
UNIVERSITY OF VIRGINIA PATENT FOUNDATION US Patent | Assay Description FRET assay can be used to effectively monitor the inhibition of CBF binding to the Runt domain of RUNX proteins (as well as for CBFβ-SMMHC bindi... | US Patent US10562890 (2020) BindingDB Entry DOI: 10.7270/Q2DR2XWH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Runt-related transcription factor 1 (Homo sapiens (Human)) | BDBM434070 (US10562890, Compound Al-10-104) | PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 2.65E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
UNIVERSITY OF VIRGINIA PATENT FOUNDATION US Patent | Assay Description FRET assay can be used to effectively monitor the inhibition of CBF binding to the Runt domain of RUNX proteins (as well as for CBFβ-SMMHC bindi... | US Patent US10562890 (2020) BindingDB Entry DOI: 10.7270/Q2DR2XWH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Runt-related transcription factor 1 (Homo sapiens (Human)) | BDBM434074 (US10562890, Compound Al-14-91) | PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 2.97E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
UNIVERSITY OF VIRGINIA PATENT FOUNDATION US Patent | Assay Description FRET assay can be used to effectively monitor the inhibition of CBF binding to the Runt domain of RUNX proteins (as well as for CBFβ-SMMHC bindi... | US Patent US10562890 (2020) BindingDB Entry DOI: 10.7270/Q2DR2XWH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Runt-related transcription factor 1 (Homo sapiens (Human)) | BDBM31175 (thiazol-2-amine, 5) | PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 3.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Virginia at Charlottesville | Assay Description His6-CBFbeta (1-141) was expressed and purified with the exception of the protease cleavage step. Cerulean-Runt domain fusion protein (Runx1 41-190) ... | Chem Biol 14: 1186-97 (2007) Article DOI: 10.1016/j.chembiol.2007.09.006 BindingDB Entry DOI: 10.7270/Q2862DTN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Runt-related transcription factor 1 (Homo sapiens (Human)) | BDBM434069 (US10562890, Compound Al-10-47) | PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | US Patent | n/a | n/a | 3.19E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
UNIVERSITY OF VIRGINIA PATENT FOUNDATION US Patent | Assay Description FRET assay can be used to effectively monitor the inhibition of CBF binding to the Runt domain of RUNX proteins (as well as for CBFβ-SMMHC bindi... | US Patent US10562890 (2020) BindingDB Entry DOI: 10.7270/Q2DR2XWH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Runt-related transcription factor 1 (Homo sapiens (Human)) | BDBM31185 (thiazol-2-amine, 17) | PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 3.20E+3 | n/a | n/a | n/a | n/a | 7.5 | 23 |
University of Virginia at Charlottesville | Assay Description For the FRET measurements, the Cerulean-Runt (Runx1 41-190) and Venus-CBFbeta (1-141) fusion proteins were dialyzed into FRET assay buffer. Protein c... | Chem Biol 14: 1186-97 (2007) Article DOI: 10.1016/j.chembiol.2007.09.006 BindingDB Entry DOI: 10.7270/Q2862DTN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Runt-related transcription factor 1 (Homo sapiens (Human)) | BDBM31186 (thiazol-2-amine, 18) | PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 3.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Virginia at Charlottesville | Assay Description His6-CBFbeta (1-141) was expressed and purified with the exception of the protease cleavage step. Cerulean-Runt domain fusion protein (Runx1 41-190) ... | Chem Biol 14: 1186-97 (2007) Article DOI: 10.1016/j.chembiol.2007.09.006 BindingDB Entry DOI: 10.7270/Q2862DTN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Runt-related transcription factor 1 (Homo sapiens (Human)) | BDBM31182 (thiazol-2-amine, 13) | PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 3.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Virginia at Charlottesville | Assay Description His6-CBFbeta (1-141) was expressed and purified with the exception of the protease cleavage step. Cerulean-Runt domain fusion protein (Runx1 41-190) ... | Chem Biol 14: 1186-97 (2007) Article DOI: 10.1016/j.chembiol.2007.09.006 BindingDB Entry DOI: 10.7270/Q2862DTN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Runt-related transcription factor 1 (Homo sapiens (Human)) | BDBM31185 (thiazol-2-amine, 17) | PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 3.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Virginia at Charlottesville | Assay Description His6-CBFbeta (1-141) was expressed and purified with the exception of the protease cleavage step. Cerulean-Runt domain fusion protein (Runx1 41-190) ... | Chem Biol 14: 1186-97 (2007) Article DOI: 10.1016/j.chembiol.2007.09.006 BindingDB Entry DOI: 10.7270/Q2862DTN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Runt-related transcription factor 1 (Homo sapiens (Human)) | BDBM29666 ((9-Oxo-9H-acridin-10-yl)-acetic acid [1-(4-chloro-...) | PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Similars | PCBioAssay | n/a | n/a | 3.58E+3 | n/a | n/a | n/a | n/a | 7.4 | 23 |
Burnham Center for Chemical Genomics Curated by PubChem BioAssay | Assay Description This assay is to identify inhibitors of the protein-protein interaction between the RUNX1 Runt domain and CBFbeta-SMMHC. This is accomplished by usin... | PubChem Bioassay (2009) BindingDB Entry DOI: 10.7270/Q25D8Q6Q | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Runt-related transcription factor 1 (Homo sapiens (Human)) | BDBM30648 (MLS-0062362.0001 | N-(4-thiazolo[5,4-b]pyridin-2-y...) | PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Similars | PCBioAssay | n/a | n/a | 3.64E+3 | n/a | n/a | n/a | n/a | 7.4 | 23 |
Burnham Center for Chemical Genomics Curated by PubChem BioAssay | Assay Description This assay is to identify inhibitors of the protein-protein interaction between the RUNX1 Runt domain and CBFbeta-SMMHC. This is accomplished by usin... | PubChem Bioassay (2009) BindingDB Entry DOI: 10.7270/Q25D8Q6Q | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Runt-related transcription factor 1 (Homo sapiens (Human)) | BDBM434072 (US10562890, Compound Al-14-55) | PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 4.83E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
UNIVERSITY OF VIRGINIA PATENT FOUNDATION US Patent | Assay Description FRET assay can be used to effectively monitor the inhibition of CBF binding to the Runt domain of RUNX proteins (as well as for CBFβ-SMMHC bindi... | US Patent US10562890 (2020) BindingDB Entry DOI: 10.7270/Q2DR2XWH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Runt-related transcription factor 1 (Homo sapiens (Human)) | BDBM434078 (US10562890, Compound Al-14-18) | PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 4.97E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
UNIVERSITY OF VIRGINIA PATENT FOUNDATION US Patent | Assay Description FRET assay can be used to effectively monitor the inhibition of CBF binding to the Runt domain of RUNX proteins (as well as for CBFβ-SMMHC bindi... | US Patent US10562890 (2020) BindingDB Entry DOI: 10.7270/Q2DR2XWH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Runt-related transcription factor 1 (Homo sapiens (Human)) | BDBM31182 (thiazol-2-amine, 13) | PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 5.00E+3 | n/a | n/a | n/a | n/a | 7.5 | 23 |
University of Virginia at Charlottesville | Assay Description For the FRET measurements, the Cerulean-Runt (Runx1 41-190) and Venus-CBFbeta (1-141) fusion proteins were dialyzed into FRET assay buffer. Protein c... | Chem Biol 14: 1186-97 (2007) Article DOI: 10.1016/j.chembiol.2007.09.006 BindingDB Entry DOI: 10.7270/Q2862DTN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Runt-related transcription factor 1 (Homo sapiens (Human)) | BDBM31178 (thiazol-2-amine, 8) | PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 6.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Virginia at Charlottesville | Assay Description His6-CBFbeta (1-141) was expressed and purified with the exception of the protease cleavage step. Cerulean-Runt domain fusion protein (Runx1 41-190) ... | Chem Biol 14: 1186-97 (2007) Article DOI: 10.1016/j.chembiol.2007.09.006 BindingDB Entry DOI: 10.7270/Q2862DTN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Runt-related transcription factor 1 (Homo sapiens (Human)) | BDBM31179 (thiazol-2-amine, 9) | PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 6.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Virginia at Charlottesville | Assay Description His6-CBFbeta (1-141) was expressed and purified with the exception of the protease cleavage step. Cerulean-Runt domain fusion protein (Runx1 41-190) ... | Chem Biol 14: 1186-97 (2007) Article DOI: 10.1016/j.chembiol.2007.09.006 BindingDB Entry DOI: 10.7270/Q2862DTN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Runt-related transcription factor 1 (Homo sapiens (Human)) | BDBM29658 (MLS000557330 | N-[3-Cyano-1-furan-2-ylmethyl-8-met...) | PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Similars | PCBioAssay | n/a | n/a | 6.54E+3 | n/a | n/a | n/a | n/a | 7.4 | 23 |
Burnham Center for Chemical Genomics Curated by PubChem BioAssay | Assay Description This assay is to identify inhibitors of the protein-protein interaction between the RUNX1 Runt domain and CBFbeta-SMMHC. This is accomplished by usin... | PubChem Bioassay (2009) BindingDB Entry DOI: 10.7270/Q2T72FSX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Runt-related transcription factor 1 (Homo sapiens (Human)) | BDBM29658 (MLS000557330 | N-[3-Cyano-1-furan-2-ylmethyl-8-met...) | PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Similars | PCBioAssay | n/a | n/a | 6.54E+3 | n/a | n/a | n/a | n/a | 7.4 | 23 |
Burnham Center for Chemical Genomics Curated by PubChem BioAssay | Assay Description This assay is to use HTS to identify inhibitors of the protein-protein interaction between the RUNX1 Runt domain and CBFbeta-SMMHC, a potential thera... | PubChem Bioassay (2009) BindingDB Entry DOI: 10.7270/Q2DV1H7P | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Runt-related transcription factor 1 (Homo sapiens (Human)) | BDBM29639 ((4E)-3-methyl-4-[[3-[(2-methyl-4-oxidanyl-phenyl)a...) | PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | PCBioAssay | n/a | n/a | 7.08E+3 | n/a | n/a | n/a | n/a | 7.4 | 23 |
Burnham Center for Chemical Genomics Curated by PubChem BioAssay | Assay Description This assay is to use HTS to identify inhibitors of the protein-protein interaction between the RUNX1 Runt domain and CBFbeta-SMMHC, a potential thera... | PubChem Bioassay (2009) BindingDB Entry DOI: 10.7270/Q2DV1H7P | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Runt-related transcription factor 1 (Homo sapiens (Human)) | BDBM29639 ((4E)-3-methyl-4-[[3-[(2-methyl-4-oxidanyl-phenyl)a...) | PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | PCBioAssay | n/a | n/a | 7.08E+3 | n/a | n/a | n/a | n/a | 7.4 | 23 |
Burnham Center for Chemical Genomics Curated by PubChem BioAssay | Assay Description This assay is to identify inhibitors of the protein-protein interaction between the RUNX1 Runt domain and CBFbeta-SMMHC. This is accomplished by usin... | PubChem Bioassay (2009) BindingDB Entry DOI: 10.7270/Q2T72FSX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Runt-related transcription factor 1 (Homo sapiens (Human)) | BDBM29643 ((6aS)-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g...) | PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars | PCBioAssay | n/a | n/a | 7.12E+3 | n/a | n/a | n/a | n/a | 7.4 | 23 |
Burnham Center for Chemical Genomics Curated by PubChem BioAssay | Assay Description This assay is to use HTS to identify inhibitors of the protein-protein interaction between the RUNX1 Runt domain and CBFbeta-SMMHC, a potential thera... | PubChem Bioassay (2009) BindingDB Entry DOI: 10.7270/Q2DV1H7P | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Runt-related transcription factor 1 (Homo sapiens (Human)) | BDBM29643 ((6aS)-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g...) | PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars | PCBioAssay | n/a | n/a | 7.12E+3 | n/a | n/a | n/a | n/a | 7.4 | 23 |
Burnham Center for Chemical Genomics Curated by PubChem BioAssay | Assay Description This assay is to identify inhibitors of the protein-protein interaction between the RUNX1 Runt domain and CBFbeta-SMMHC. This is accomplished by usin... | PubChem Bioassay (2009) BindingDB Entry DOI: 10.7270/Q2T72FSX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Runt-related transcription factor 1 (Homo sapiens (Human)) | BDBM29672 (5-(2-keto-7-methoxy-4-propionyloxy-6-propyl-chrome...) | PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Similars | PCBioAssay | n/a | n/a | 7.94E+3 | n/a | n/a | n/a | n/a | 7.4 | 23 |
Burnham Center for Chemical Genomics Curated by PubChem BioAssay | Assay Description This assay is to identify inhibitors of the protein-protein interaction between the RUNX1 Runt domain and CBFbeta-SMMHC. This is accomplished by usin... | PubChem Bioassay (2009) BindingDB Entry DOI: 10.7270/Q2T72FSX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Runt-related transcription factor 1 (Homo sapiens (Human)) | BDBM29672 (5-(2-keto-7-methoxy-4-propionyloxy-6-propyl-chrome...) | PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Similars | PCBioAssay | n/a | n/a | 7.94E+3 | n/a | n/a | n/a | n/a | 7.4 | 23 |
Burnham Center for Chemical Genomics Curated by PubChem BioAssay | Assay Description This assay is to use HTS to identify inhibitors of the protein-protein interaction between the RUNX1 Runt domain and CBFbeta-SMMHC, a potential thera... | PubChem Bioassay (2009) BindingDB Entry DOI: 10.7270/Q2DV1H7P | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Runt-related transcription factor 1 (Homo sapiens (Human)) | BDBM29643 ((6aS)-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g...) | PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars | PCBioAssay | n/a | n/a | 8.48E+3 | n/a | n/a | n/a | n/a | 7.4 | 23 |
Burnham Center for Chemical Genomics Curated by PubChem BioAssay | Assay Description This assay is to identify inhibitors of the protein-protein interaction between the RUNX1 Runt domain and CBFbeta-SMMHC. This is accomplished by usin... | PubChem Bioassay (2009) BindingDB Entry DOI: 10.7270/Q25D8Q6Q | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Runt-related transcription factor 1 (Homo sapiens (Human)) | BDBM29632 (2-[2-(3-keto-1,2-benzothiazol-2-yl)thiazol-4-yl]ac...) | PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Similars | PCBioAssay | n/a | n/a | 8.58E+3 | n/a | n/a | n/a | n/a | 7.4 | 23 |
Burnham Center for Chemical Genomics Curated by PubChem BioAssay | Assay Description This assay is to use HTS to identify inhibitors of the protein-protein interaction between the RUNX1 Runt domain and CBFbeta-SMMHC, a potential thera... | PubChem Bioassay (2009) BindingDB Entry DOI: 10.7270/Q2DV1H7P | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Runt-related transcription factor 1 (Homo sapiens (Human)) | BDBM29632 (2-[2-(3-keto-1,2-benzothiazol-2-yl)thiazol-4-yl]ac...) | PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Similars | PCBioAssay | n/a | n/a | 8.58E+3 | n/a | n/a | n/a | n/a | 7.4 | 23 |
Burnham Center for Chemical Genomics Curated by PubChem BioAssay | Assay Description This assay is to identify inhibitors of the protein-protein interaction between the RUNX1 Runt domain and CBFbeta-SMMHC. This is accomplished by usin... | PubChem Bioassay (2009) BindingDB Entry DOI: 10.7270/Q2T72FSX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Runt-related transcription factor 1 (Homo sapiens (Human)) | BDBM434073 (US10562890, Compound Al-12-126) | PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 8.91E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
UNIVERSITY OF VIRGINIA PATENT FOUNDATION US Patent | Assay Description FRET assay can be used to effectively monitor the inhibition of CBF binding to the Runt domain of RUNX proteins (as well as for CBFβ-SMMHC bindi... | US Patent US10562890 (2020) BindingDB Entry DOI: 10.7270/Q2DR2XWH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Runt-related transcription factor 1 (Homo sapiens (Human)) | BDBM31178 (thiazol-2-amine, 8) | PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 9.00E+3 | n/a | n/a | n/a | n/a | 7.5 | 23 |
University of Virginia at Charlottesville | Assay Description For the FRET measurements, the Cerulean-Runt (Runx1 41-190) and Venus-CBFbeta (1-141) fusion proteins were dialyzed into FRET assay buffer. Protein c... | Chem Biol 14: 1186-97 (2007) Article DOI: 10.1016/j.chembiol.2007.09.006 BindingDB Entry DOI: 10.7270/Q2862DTN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Runt-related transcription factor 1 (Homo sapiens (Human)) | BDBM31175 (thiazol-2-amine, 5) | PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 9.00E+3 | n/a | n/a | n/a | n/a | 7.5 | 23 |
University of Virginia at Charlottesville | Assay Description For the FRET measurements, the Cerulean-Runt (Runx1 41-190) and Venus-CBFbeta (1-141) fusion proteins were dialyzed into FRET assay buffer. Protein c... | Chem Biol 14: 1186-97 (2007) Article DOI: 10.1016/j.chembiol.2007.09.006 BindingDB Entry DOI: 10.7270/Q2862DTN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Runt-related transcription factor 1 (Homo sapiens (Human)) | BDBM29644 ((6aR)-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g...) | PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase DrugBank PC cid PC sid PDB UniChem Similars | PCBioAssay | n/a | n/a | 9.81E+3 | n/a | n/a | n/a | n/a | 7.4 | 23 |
Burnham Center for Chemical Genomics Curated by PubChem BioAssay | Assay Description This assay is to use HTS to identify inhibitors of the protein-protein interaction between the RUNX1 Runt domain and CBFbeta-SMMHC, a potential thera... | PubChem Bioassay (2009) BindingDB Entry DOI: 10.7270/Q2DV1H7P | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Runt-related transcription factor 1 (Homo sapiens (Human)) | BDBM29644 ((6aR)-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g...) | PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase DrugBank PC cid PC sid PDB UniChem Similars | PCBioAssay | n/a | n/a | 9.81E+3 | n/a | n/a | n/a | n/a | 7.4 | 23 |
Burnham Center for Chemical Genomics Curated by PubChem BioAssay | Assay Description This assay is to identify inhibitors of the protein-protein interaction between the RUNX1 Runt domain and CBFbeta-SMMHC. This is accomplished by usin... | PubChem Bioassay (2009) BindingDB Entry DOI: 10.7270/Q2T72FSX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Runt-related transcription factor 1 (Homo sapiens (Human)) | BDBM29668 (2-(1-{[4-(2,5-Dimethyl-phenyl)-thiazol-2-yl]-hydra...) | PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | PCBioAssay | n/a | n/a | 1.01E+4 | n/a | n/a | n/a | n/a | 7.4 | 23 |
Burnham Center for Chemical Genomics Curated by PubChem BioAssay | Assay Description This assay is to identify inhibitors of the protein-protein interaction between the RUNX1 Runt domain and CBFbeta-SMMHC. This is accomplished by usin... | PubChem Bioassay (2009) BindingDB Entry DOI: 10.7270/Q2T72FSX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Runt-related transcription factor 1 (Homo sapiens (Human)) | BDBM29668 (2-(1-{[4-(2,5-Dimethyl-phenyl)-thiazol-2-yl]-hydra...) | PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | PCBioAssay | n/a | n/a | 1.01E+4 | n/a | n/a | n/a | n/a | 7.4 | 23 |
Burnham Center for Chemical Genomics Curated by PubChem BioAssay | Assay Description This assay is to use HTS to identify inhibitors of the protein-protein interaction between the RUNX1 Runt domain and CBFbeta-SMMHC, a potential thera... | PubChem Bioassay (2009) BindingDB Entry DOI: 10.7270/Q2DV1H7P | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Runt-related transcription factor 1 (Homo sapiens (Human)) | BDBM576 (1-Diphenylamino-pyrrole-2,5-dione | MLS000590474 |...) | PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | PCBioAssay | n/a | n/a | 1.03E+4 | n/a | n/a | n/a | n/a | 7.4 | 23 |
Burnham Center for Chemical Genomics Curated by PubChem BioAssay | Assay Description This assay is to identify inhibitors of the protein-protein interaction between the RUNX1 Runt domain and CBFbeta-SMMHC. This is accomplished by usin... | PubChem Bioassay (2009) BindingDB Entry DOI: 10.7270/Q25D8Q6Q | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Runt-related transcription factor 1 (Homo sapiens (Human)) | BDBM29685 ((3E)-3-(2-furanylmethylidene)-1,2-dihydrocyclopent...) | PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Similars | PCBioAssay | n/a | n/a | 1.04E+4 | n/a | n/a | n/a | n/a | 7.4 | 23 |
Burnham Center for Chemical Genomics Curated by PubChem BioAssay | Assay Description This assay is to use HTS to identify inhibitors of the protein-protein interaction between the RUNX1 Runt domain and CBFbeta-SMMHC, a potential thera... | PubChem Bioassay (2009) BindingDB Entry DOI: 10.7270/Q2DV1H7P | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Runt-related transcription factor 1 (Homo sapiens (Human)) | BDBM29685 ((3E)-3-(2-furanylmethylidene)-1,2-dihydrocyclopent...) | PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Similars | PCBioAssay | n/a | n/a | 1.04E+4 | n/a | n/a | n/a | n/a | 7.4 | 23 |
Burnham Center for Chemical Genomics Curated by PubChem BioAssay | Assay Description This assay is to identify inhibitors of the protein-protein interaction between the RUNX1 Runt domain and CBFbeta-SMMHC. This is accomplished by usin... | PubChem Bioassay (2009) BindingDB Entry DOI: 10.7270/Q2T72FSX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Runt-related transcription factor 1 (Homo sapiens (Human)) | BDBM29684 ((3E)-3-(2-furanylmethylidene)-1,2-dihydrocyclopent...) | PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Similars | PCBioAssay | n/a | n/a | 1.06E+4 | n/a | n/a | n/a | n/a | 7.4 | 23 |
Burnham Center for Chemical Genomics Curated by PubChem BioAssay | Assay Description This assay is to identify inhibitors of the protein-protein interaction between the RUNX1 Runt domain and CBFbeta-SMMHC. This is accomplished by usin... | PubChem Bioassay (2009) BindingDB Entry DOI: 10.7270/Q2T72FSX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Runt-related transcription factor 1 (Homo sapiens (Human)) | BDBM29684 ((3E)-3-(2-furanylmethylidene)-1,2-dihydrocyclopent...) | PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Similars | PCBioAssay | n/a | n/a | 1.06E+4 | n/a | n/a | n/a | n/a | 7.4 | 23 |
Burnham Center for Chemical Genomics Curated by PubChem BioAssay | Assay Description This assay is to use HTS to identify inhibitors of the protein-protein interaction between the RUNX1 Runt domain and CBFbeta-SMMHC, a potential thera... | PubChem Bioassay (2009) BindingDB Entry DOI: 10.7270/Q2DV1H7P | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Runt-related transcription factor 1 (Homo sapiens (Human)) | BDBM29666 ((9-Oxo-9H-acridin-10-yl)-acetic acid [1-(4-chloro-...) | PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Similars | PCBioAssay | n/a | n/a | 1.16E+4 | n/a | n/a | n/a | n/a | 7.4 | 23 |
Burnham Center for Chemical Genomics Curated by PubChem BioAssay | Assay Description This assay is to identify inhibitors of the protein-protein interaction between the RUNX1 Runt domain and CBFbeta-SMMHC. This is accomplished by usin... | PubChem Bioassay (2009) BindingDB Entry DOI: 10.7270/Q2T72FSX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Runt-related transcription factor 1 (Homo sapiens (Human)) | BDBM29666 ((9-Oxo-9H-acridin-10-yl)-acetic acid [1-(4-chloro-...) | PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Similars | PCBioAssay | n/a | n/a | 1.16E+4 | n/a | n/a | n/a | n/a | 7.4 | 23 |
Burnham Center for Chemical Genomics Curated by PubChem BioAssay | Assay Description This assay is to use HTS to identify inhibitors of the protein-protein interaction between the RUNX1 Runt domain and CBFbeta-SMMHC, a potential thera... | PubChem Bioassay (2009) BindingDB Entry DOI: 10.7270/Q2DV1H7P | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Runt-related transcription factor 1 (Homo sapiens (Human)) | BDBM29661 (2-Amino-1-furan-2-ylmethyl-1H-pyrrolo[2,3-b]quinox...) | PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Similars | PCBioAssay | n/a | n/a | 1.17E+4 | n/a | n/a | n/a | n/a | 7.4 | 23 |
Burnham Center for Chemical Genomics Curated by PubChem BioAssay | Assay Description This assay is to identify inhibitors of the protein-protein interaction between the RUNX1 Runt domain and CBFbeta-SMMHC. This is accomplished by usin... | PubChem Bioassay (2009) BindingDB Entry DOI: 10.7270/Q2T72FSX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Runt-related transcription factor 1 (Homo sapiens (Human)) | BDBM29661 (2-Amino-1-furan-2-ylmethyl-1H-pyrrolo[2,3-b]quinox...) | PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Similars | PCBioAssay | n/a | n/a | 1.17E+4 | n/a | n/a | n/a | n/a | 7.4 | 23 |
Burnham Center for Chemical Genomics Curated by PubChem BioAssay | Assay Description This assay is to use HTS to identify inhibitors of the protein-protein interaction between the RUNX1 Runt domain and CBFbeta-SMMHC, a potential thera... | PubChem Bioassay (2009) BindingDB Entry DOI: 10.7270/Q2DV1H7P | |||||||||||
More data for this Ligand-Target Pair |
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