Compile Data Set for Download or QSAR

Found 1496 hits of ic50 data for polymerid = 375   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Phosphatidylinositol 3-kinase regulatory subunit alpha (Homo sapiens (Human))	BDBM318958 (N-(5-(2,6-dimorpholinopyrimidin-4-yl)-4-(trifluoro...) Show SMILES CC(=O)Nc1cc(c(cn1)-c1cc(nc(n1)N1CCOCC1)N1CCOCC1)C(F)(F)F Show InChI InChI=1S/C20H23F3N6O3/c1-13(30)25-17-10-15(20(21,22)23)14(12-24-17)16-11-18(28-2-6-31-7-3-28)27-19(26-16)29-4-8-32-9-5-29/h10-12H,2-9H2,1H3,(H,24,25,30)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.400	n/a	n/a	n/a	n/a	n/a	n/a
Teligene Ltd. US Patent					Assay Description An in vitro assay which determines the ability of a test compound to inhibit PI3K alpha activity: PI3 alpha (PIK3CA) kinase-tagged T7 phage strains w...				US Patent US10173995 (2019) BindingDB Entry DOI: 10.7270/Q2H70HX0
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha (Homo sapiens (Human))	BDBM319549 (US10173995, Compound 9) Show SMILES NCC(=O)Nc1cc(c(cn1)-c1cc(nc(n1)N1CCOCC1)N1CCOCC1)C(F)(F)F Show InChI InChI=1S/C20H24F3N7O3/c21-20(22,23)14-9-16(27-18(31)11-24)25-12-13(14)15-10-17(29-1-5-32-6-2-29)28-19(26-15)30-3-7-33-8-4-30/h9-10,12H,1-8,11,24H2,(H,25,27,31)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.840	n/a	n/a	n/a	n/a	n/a	n/a
Teligene Ltd. US Patent					Assay Description An in vitro assay which determines the ability of a test compound to inhibit PI3K alpha activity: PI3 alpha (PIK3CA) kinase-tagged T7 phage strains w...				US Patent US10173995 (2019) BindingDB Entry DOI: 10.7270/Q2H70HX0
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha (Homo sapiens (Human))	BDBM318959 (5-(2,6-dimorpholinopyrimidin-4-yl)-N-methyl-4-(tri...) Show SMILES CNc1cc(c(cn1)-c1cc(nc(n1)N1CCOCC1)N1CCOCC1)C(F)(F)F Show InChI InChI=1S/C19H23F3N6O2/c1-23-16-10-14(19(20,21)22)13(12-24-16)15-11-17(27-2-6-29-7-3-27)26-18(25-15)28-4-8-30-9-5-28/h10-12H,2-9H2,1H3,(H,23,24)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.90	n/a	n/a	n/a	n/a	n/a	n/a
Teligene Ltd. US Patent					Assay Description An in vitro assay which determines the ability of a test compound to inhibit PI3K alpha activity: PI3 alpha (PIK3CA) kinase-tagged T7 phage strains w...				US Patent US10173995 (2019) BindingDB Entry DOI: 10.7270/Q2H70HX0
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha (Homo sapiens (Human))	BDBM4622 (3-[(6,7-dimethoxyquinazolin-4-yl)amino]phenol | An...) Show SMILES COc1cc2ncnc(Nc3cccc(O)c3)c2cc1OC Show InChI InChI=1S/C16H15N3O3/c1-21-14-7-12-13(8-15(14)22-2)17-9-18-16(12)19-10-4-3-5-11(20)6-10/h3-9,20H,1-2H3,(H,17,18,19)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
University of Oxford Curated by ChEMBL					Assay Description Inhibition of PI3K				Proc Natl Acad Sci USA 104: 20523-8 (2007) Checked by Author Article DOI: 10.1073/pnas.0708800104 BindingDB Entry DOI: 10.7270/Q2DB82RH
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha (Homo sapiens (Human))	BDBM330295 (Methyl (5-(6-((4-(methylsulfonyl)piperazin-1-yl)me...) Show SMILES COC(=O)Nc1cc(c(cn1)-c1nc(N2CCOCC2)c2cc(CN3CCN(CC3)S(C)(=O)=O)cn2n1)C(F)(F)F Show InChI InChI=1S/C24H29F3N8O5S/c1-39-23(36)29-20-12-18(24(25,26)27)17(13-28-20)21-30-22(33-7-9-40-10-8-33)19-11-16(15-35(19)31-21)14-32-3-5-34(6-4-32)41(2,37)38/h11-13,15H,3-10,14H2,1-2H3,(H,28,29,36)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	US Patent	n/a	n/a	2.84	n/a	n/a	n/a	n/a	n/a	n/a
Shanghai Institute of Materia Medica, Chinese Academy of Sciences; Shanghai Haihe Pharmaceutical Co., Ltd. US Patent					Assay Description The activity of purified kinase was detected with Kinase-Glo® Plus kinase luminescent assay by measuring the amount of the remaining Kinase in the so...				US Patent US9724352 (2017) BindingDB Entry DOI: 10.7270/Q2GM89D9
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha (Homo sapiens (Human))	BDBM330296 ((S)-methyl (5-(4-(3-methylmorpholino)-6-((4-(methy...) Show SMILES COC(=O)Nc1cc(c(cn1)-c1nc(N2CCOC[C@@H]2C)c2cc(CN3CCN(CC3)S(C)(=O)=O)cn2n1)C(F)(F)F Show InChI InChI=1S/C25H31F3N8O5S/c1-16-15-41-9-8-35(16)23-20-10-17(13-33-4-6-34(7-5-33)42(3,38)39)14-36(20)32-22(31-23)18-12-29-21(30-24(37)40-2)11-19(18)25(26,27)28/h10-12,14,16H,4-9,13,15H2,1-3H3,(H,29,30,37)/t16-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.67	n/a	n/a	n/a	n/a	n/a	n/a
Shanghai Institute of Materia Medica, Chinese Academy of Sciences; Shanghai Haihe Pharmaceutical Co., Ltd. US Patent					Assay Description The activity of purified kinase was detected with Kinase-Glo® Plus kinase luminescent assay by measuring the amount of the remaining Kinase in the so...				US Patent US9724352 (2017) BindingDB Entry DOI: 10.7270/Q2GM89D9
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha (Homo sapiens (Human))	BDBM330294 (Ethyl (5-(6-((4-(methylsulfonyl)piperazin-1-yl)met...) Show SMILES CCOC(=O)Nc1cc(c(cn1)-c1nc(N2CCOCC2)c2cc(CN3CCN(CC3)S(C)(=O)=O)cn2n1)C(F)(F)F Show InChI InChI=1S/C25H31F3N8O5S/c1-3-41-24(37)30-21-13-19(25(26,27)28)18(14-29-21)22-31-23(34-8-10-40-11-9-34)20-12-17(16-36(20)32-22)15-33-4-6-35(7-5-33)42(2,38)39/h12-14,16H,3-11,15H2,1-2H3,(H,29,30,37)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	7.15	n/a	n/a	n/a	n/a	n/a	n/a
Shanghai Institute of Materia Medica, Chinese Academy of Sciences; Shanghai Haihe Pharmaceutical Co., Ltd. US Patent					Assay Description The activity of purified kinase was detected with Kinase-Glo® Plus kinase luminescent assay by measuring the amount of the remaining Kinase in the so...				US Patent US9724352 (2017) BindingDB Entry DOI: 10.7270/Q2GM89D9
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha (Homo sapiens (Human))	BDBM330293 (1-ethyl-3-(5-(6-((4-(methylsulfonyl)piperazin-1-yl...) Show SMILES CCNC(=O)Nc1cc(c(cn1)-c1nc(N2CCOCC2)c2cc(CN3CCN(CC3)S(C)(=O)=O)cn2n1)C(F)(F)F Show InChI InChI=1S/C25H32F3N9O4S/c1-3-29-24(38)31-21-13-19(25(26,27)28)18(14-30-21)22-32-23(35-8-10-41-11-9-35)20-12-17(16-37(20)33-22)15-34-4-6-36(7-5-34)42(2,39)40/h12-14,16H,3-11,15H2,1-2H3,(H2,29,30,31,38)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	8.19	n/a	n/a	n/a	n/a	n/a	n/a
Shanghai Institute of Materia Medica, Chinese Academy of Sciences; Shanghai Haihe Pharmaceutical Co., Ltd. US Patent					Assay Description The activity of purified kinase was detected with Kinase-Glo® Plus kinase luminescent assay by measuring the amount of the remaining Kinase in the so...				US Patent US9724352 (2017) BindingDB Entry DOI: 10.7270/Q2GM89D9
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha (Homo sapiens (Human))	BDBM330259 (5-(6-((4-(methylsulfonyl)piperazin-1-yl)methyl)-4-...) Show SMILES CS(=O)(=O)N1CCN(Cc2cc3c(nc(nn3c2)-c2cnc(N)cc2C(F)(F)F)N2CCOCC2)CC1 Show InChI InChI=1S/C22H27F3N8O3S/c1-37(34,35)32-4-2-30(3-5-32)13-15-10-18-21(31-6-8-36-9-7-31)28-20(29-33(18)14-15)16-12-27-19(26)11-17(16)22(23,24)25/h10-12,14H,2-9,13H2,1H3,(H2,26,27)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	8.37	n/a	n/a	n/a	n/a	n/a	n/a
Shanghai Institute of Materia Medica, Chinese Academy of Sciences; Shanghai Haihe Pharmaceutical Co., Ltd. US Patent					Assay Description The activity of purified kinase was detected with Kinase-Glo® Plus kinase luminescent assay by measuring the amount of the remaining Kinase in the so...				US Patent US9724352 (2017) BindingDB Entry DOI: 10.7270/Q2GM89D9
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha (Homo sapiens (Human))	BDBM330292 (1-(4-fluorophenyl)-3-(5-(6-((4-(methylsulfonyl)pip...) Show SMILES CS(=O)(=O)N1CCN(Cc2cc3c(nc(nn3c2)-c2cnc(NC(=O)Nc3ccc(F)cc3)cc2C(F)(F)F)N2CCOCC2)CC1 Show InChI InChI=1S/C29H31F4N9O4S/c1-47(44,45)41-8-6-39(7-9-41)17-19-14-24-27(40-10-12-46-13-11-40)37-26(38-42(24)18-19)22-16-34-25(15-23(22)29(31,32)33)36-28(43)35-21-4-2-20(30)3-5-21/h2-5,14-16,18H,6-13,17H2,1H3,(H2,34,35,36,43)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	9.30	n/a	n/a	n/a	n/a	n/a	n/a
Shanghai Institute of Materia Medica, Chinese Academy of Sciences; Shanghai Haihe Pharmaceutical Co., Ltd. US Patent					Assay Description The activity of purified kinase was detected with Kinase-Glo® Plus kinase luminescent assay by measuring the amount of the remaining Kinase in the so...				US Patent US9724352 (2017) BindingDB Entry DOI: 10.7270/Q2GM89D9
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha (Homo sapiens (Human))	BDBM330258 (1-(4-(4-methylpiperazine-carbonyl)phenyl)-3-(4-(6-...) Show SMILES CN1CCN(CC1)C(=O)c1ccc(NC(=O)Nc2ccc(cc2)-c2nc(N3CCOCC3)c3cc(CN4CCN(CC4)S(C)(=O)=O)cn3n2)cc1 Show InChI InChI=1S/C35H44N10O5S/c1-40-11-15-43(16-12-40)34(46)28-5-9-30(10-6-28)37-35(47)36-29-7-3-27(4-8-29)32-38-33(42-19-21-50-22-20-42)31-23-26(25-45(31)39-32)24-41-13-17-44(18-14-41)51(2,48)49/h3-10,23,25H,11-22,24H2,1-2H3,(H2,36,37,47)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	9.59	n/a	n/a	n/a	n/a	n/a	n/a
Shanghai Institute of Materia Medica, Chinese Academy of Sciences; Shanghai Haihe Pharmaceutical Co., Ltd. US Patent					Assay Description The activity of purified kinase was detected with Kinase-Glo® Plus kinase luminescent assay by measuring the amount of the remaining Kinase in the so...				US Patent US9724352 (2017) BindingDB Entry DOI: 10.7270/Q2GM89D9
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha (Homo sapiens (Human))	BDBM228248 ((R)-3-methyl-8-(6-(1-methyl-1H-pyrazol-4-yl)pyridi...) Show SMILES Cn1cc(cn1)-c1ccc(cn1)-c1ccc2ncc3n(C)c(=O)n([C@@H]4CCCN(C4)S(C)(=O)=O)c3c2c1 |r| Show InChI InChI=1S/C26H27N7O3S/c1-30-15-19(13-29-30)22-8-7-18(12-27-22)17-6-9-23-21(11-17)25-24(14-28-23)31(2)26(34)33(25)20-5-4-10-32(16-20)37(3,35)36/h6-9,11-15,20H,4-5,10,16H2,1-3H3/t20-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
BEIJING FORELANDPHARMA CO. LTD. US Patent					Assay Description PI3K alpha-ADP Glo Assay was employed. In the determination of PI3K enzyme activity, the detection kit supplied by Promega (Promega, Cat #: V9101) wa...				US Patent US10047084 (2018) BindingDB Entry DOI: 10.7270/Q2DZ0B95
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha (Homo sapiens (Human))	BDBM228245 ((S)-3-methyl-8-(6-(1-methyl-1H-pyrazol-4-yl)pyridi...) Show SMILES Cn1cc(cn1)-c1ccc(cn1)-c1ccc2ncc3n(C)c(=O)n([C@H]4CCN(C4)S(C)(=O)=O)c3c2c1 |r| Show InChI InChI=1S/C25H25N7O3S/c1-29-14-18(12-28-29)21-6-5-17(11-26-21)16-4-7-22-20(10-16)24-23(13-27-22)30(2)25(33)32(24)19-8-9-31(15-19)36(3,34)35/h4-7,10-14,19H,8-9,15H2,1-3H3/t19-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
BEIJING FORELANDPHARMA CO. LTD. US Patent					Assay Description PI3K alpha-ADP Glo Assay was employed. In the determination of PI3K enzyme activity, the detection kit supplied by Promega (Promega, Cat #: V9101) wa...				US Patent US10047084 (2018) BindingDB Entry DOI: 10.7270/Q2DZ0B95
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha (Homo sapiens (Human))	BDBM228243 ((R)-3-methyl-8-(6-(1-methyl-1H-pyrazol-4-yl)pyridi...) Show SMILES Cn1cc(cn1)-c1ccc(cn1)-c1ccc2ncc3n(C)c(=O)n([C@@H]4CCN(C4)S(C)(=O)=O)c3c2c1 |r| Show InChI InChI=1S/C25H25N7O3S/c1-29-14-18(12-28-29)21-6-5-17(11-26-21)16-4-7-22-20(10-16)24-23(13-27-22)30(2)25(33)32(24)19-8-9-31(15-19)36(3,34)35/h4-7,10-14,19H,8-9,15H2,1-3H3/t19-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
BEIJING FORELANDPHARMA CO. LTD. US Patent					Assay Description PI3K alpha-ADP Glo Assay was employed. In the determination of PI3K enzyme activity, the detection kit supplied by Promega (Promega, Cat #: V9101) wa...				US Patent US10047084 (2018) BindingDB Entry DOI: 10.7270/Q2DZ0B95
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha (Homo sapiens (Human))	BDBM228204 (3-methyl-8-(6-(1-methyl-1H-pyrazol-4-yl)pyridin-3-...) Show SMILES Cn1cc(cn1)-c1ccc(cn1)-c1ccc2ncc3n(C)c(=O)n(C4CCCN(C4)S(C)(=O)=O)c3c2c1 Show InChI InChI=1S/C26H27N7O3S/c1-30-15-19(13-29-30)22-8-7-18(12-27-22)17-6-9-23-21(11-17)25-24(14-28-23)31(2)26(34)33(25)20-5-4-10-32(16-20)37(3,35)36/h6-9,11-15,20H,4-5,10,16H2,1-3H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
BEIJING FORELANDPHARMA CO. LTD. US Patent					Assay Description PI3K alpha-ADP Glo Assay was employed. In the determination of PI3K enzyme activity, the detection kit supplied by Promega (Promega, Cat #: V9101) wa...				US Patent US10047084 (2018) BindingDB Entry DOI: 10.7270/Q2DZ0B95
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha (Homo sapiens (Human))	BDBM228226 (1-((1s,4s)-4-hydroxycyclohexyl)-3-methyl-8-(6-(1-m...) Show SMILES Cn1cc(cn1)-c1ccc(cn1)-c1ccc2ncc3n(C)c(=O)n([C@@H]4CC[C@H](O)CC4)c3c2c1 |r,wU:24.25,27.29,(-7.7,4.27,;-6.93,2.93,;-5.47,2.46,;-5.47,.92,;-6.93,.44,;-7.84,1.69,;-4.13,.15,;-4.13,-1.39,;-2.8,-2.16,;-1.46,-1.39,;-1.46,.15,;-2.8,.92,;-.13,-2.16,;-.13,-3.7,;1.2,-4.47,;2.54,-3.7,;3.87,-4.47,;5.2,-3.7,;5.2,-2.16,;6.35,-1.13,;7.84,-1.53,;5.72,.28,;6.49,1.61,;4.19,.12,;3.1,1.2,;3.5,2.69,;2.41,3.78,;.92,3.38,;-.17,4.47,;.52,1.89,;1.61,.81,;3.87,-1.39,;2.54,-2.16,;1.2,-1.39,)| Show InChI InChI=1S/C26H26N6O2/c1-30-15-18(13-29-30)22-9-4-17(12-27-22)16-3-10-23-21(11-16)25-24(14-28-23)31(2)26(34)32(25)19-5-7-20(33)8-6-19/h3-4,9-15,19-20,33H,5-8H2,1-2H3/t19-,20+	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
BEIJING FORELANDPHARMA CO. LTD. US Patent					Assay Description PI3K alpha-ADP Glo Assay was employed. In the determination of PI3K enzyme activity, the detection kit supplied by Promega (Promega, Cat #: V9101) wa...				US Patent US10047084 (2018) BindingDB Entry DOI: 10.7270/Q2DZ0B95
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha (Homo sapiens (Human))	BDBM318960 (5-(2,6-dimorpholinopyrimidin-4-yl)-N-ethyl-4-(trif...) Show SMILES CCNc1cc(c(cn1)-c1cc(nc(n1)N1CCOCC1)N1CCOCC1)C(F)(F)F Show InChI InChI=1S/C20H25F3N6O2/c1-2-24-17-11-15(20(21,22)23)14(13-25-17)16-12-18(28-3-7-30-8-4-28)27-19(26-16)29-5-9-31-10-6-29/h11-13H,2-10H2,1H3,(H,24,25)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
Teligene Ltd. US Patent					Assay Description An in vitro assay which determines the ability of a test compound to inhibit PI3K alpha activity: PI3 alpha (PIK3CA) kinase-tagged T7 phage strains w...				US Patent US10173995 (2019) BindingDB Entry DOI: 10.7270/Q2H70HX0
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha (Homo sapiens (Human))	BDBM50610455 (CHEMBL5287428) Show SMILES CN(C1CCN(CC1)C(=O)c1ccccc1)c1nc(nc(n1)-c1cnc(N)nc1)N1CCOCC1 Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	UniChem		n/a	n/a	15	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha (Homo sapiens (Human))	BDBM224568 (US9321773, 4) Show SMILES Nc1ncnc2n(Cc3nc4cccc(C#CCCCC(O)=O)c4c(=O)n3Cc3ccccc3Cl)nc(-c3ccc(O)cc3)c12 Show InChI InChI=1S/C33H26ClN7O4/c34-24-10-5-4-8-22(24)17-40-26(38-25-11-6-9-20(28(25)33(40)45)7-2-1-3-12-27(43)44)18-41-32-29(31(35)36-19-37-32)30(39-41)21-13-15-23(42)16-14-21/h4-6,8-11,13-16,19,42H,1,3,12,17-18H2,(H,43,44)(H2,35,36,37)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	17	n/a	n/a	n/a	n/a	n/a	n/a
Respivert, Ltd. US Patent					Assay Description PI3 kinases catalyse the phosphorylation of phosphatidylinositol 4,5-biphosphate (PIP2) to phosphatidylinositol 3,4,5-triphosphate (PIP3) in the pres...				US Patent US9321773 (2016) BindingDB Entry DOI: 10.7270/Q2MG7NCG
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha (Homo sapiens (Human))	BDBM295053 (US10112926, Example 8.1 | US10112926, Example 8.2) Show SMILES Cc1noc(n1)-c1cc(cnc1N)-c1cc(ccc1C)S(=O)(=O)N[C@H]1CC2(C[C@H](O)C2)C1 |r,wU:24.26,28.31,(5.15,-7.55,;4.38,-6.22,;5.29,-4.97,;4.38,-3.73,;2.92,-4.2,;2.92,-5.74,;1.59,-3.43,;.25,-4.2,;-1.08,-3.43,;-1.08,-1.89,;.25,-1.12,;1.59,-1.89,;2.92,-1.12,;-2.42,-4.2,;-2.42,-5.74,;-3.75,-6.51,;-5.08,-5.74,;-5.08,-4.2,;-3.75,-3.43,;-3.75,-1.89,;-3.75,-8.05,;-2.21,-8.05,;-5.29,-8.05,;-3.75,-9.59,;-2.42,-10.36,;-.93,-9.97,;-.53,-11.45,;-.13,-12.94,;1.36,-12.54,;2.69,-13.31,;.96,-11.05,;-2.02,-11.85,)| Show InChI InChI=1S/C22H25N5O4S/c1-12-3-4-17(32(29,30)27-15-7-22(8-15)9-16(28)10-22)6-18(12)14-5-19(20(23)24-11-14)21-25-13(2)26-31-21/h3-6,11,15-16,27-28H,7-10H2,1-2H3,(H2,23,24)/t15-,16-,22?	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	20	n/a	n/a	n/a	n/a	7.5	25
Novartis AG US Patent					Assay Description The luminescence-based ATP detection reagent KinaseGlo was obtained from Promega, (Cat. No. V6714, Lot No. 236161) through Catalys, Wallisellen, Swit...				US Patent US10112926 (2018) BindingDB Entry DOI: 10.7270/Q22R3TQ9
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha (Homo sapiens (Human))	BDBM224569 (US9321773, 5) Show SMILES Nc1ncnc2n(Cc3nc4cccc(C#CCCCC(=O)N5CCOCC5)c4c(=O)n3Cc3ccccc3Cl)nc(-c3ccc(O)cc3)c12 Show InChI InChI=1S/C37H33ClN8O4/c38-28-10-5-4-8-26(28)21-45-30(22-46-36-33(35(39)40-23-41-36)34(43-46)25-13-15-27(47)16-14-25)42-29-11-6-9-24(32(29)37(45)49)7-2-1-3-12-31(48)44-17-19-50-20-18-44/h4-6,8-11,13-16,23,47H,1,3,12,17-22H2,(H2,39,40,41)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
Respivert, Ltd. US Patent					Assay Description PI3 kinases catalyse the phosphorylation of phosphatidylinositol 4,5-biphosphate (PIP2) to phosphatidylinositol 3,4,5-triphosphate (PIP3) in the pres...				US Patent US9321773 (2016) BindingDB Entry DOI: 10.7270/Q2MG7NCG
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha (Homo sapiens (Human))	BDBM224571 (US9321773, 86) Show SMILES CC(C)NC(=O)CCCC#Cc1cccc2nc(Cn3nc(-c4ccc(O)cc4)c4c(N)ncnc34)n(Cc3ccccc3Cl)c(=O)c12 Show InChI InChI=1S/C36H33ClN8O3/c1-22(2)41-30(47)14-5-3-4-9-23-11-8-13-28-31(23)36(48)44(19-25-10-6-7-12-27(25)37)29(42-28)20-45-35-32(34(38)39-21-40-35)33(43-45)24-15-17-26(46)18-16-24/h6-8,10-13,15-18,21-22,46H,3,5,14,19-20H2,1-2H3,(H,41,47)(H2,38,39,40)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	27	n/a	n/a	n/a	n/a	n/a	n/a
Respivert, Ltd. US Patent					Assay Description PI3 kinases catalyse the phosphorylation of phosphatidylinositol 4,5-biphosphate (PIP2) to phosphatidylinositol 3,4,5-triphosphate (PIP3) in the pres...				US Patent US9321773 (2016) BindingDB Entry DOI: 10.7270/Q2MG7NCG
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha (Homo sapiens (Human))	BDBM295193 (US10112926, Example 77 | trans-3-(2-Amino-2′...) Show SMILES Cc1cc(ccn1)-c1cc(cnc1N)-c1cc(ccc1C)S(=O)(=O)N[C@H]1CC[C@H](CO)CC1 |r,wU:25.27,wD:28.31,(8.67,3.46,;7.34,2.69,;6,3.47,;4.67,2.69,;4.67,1.16,;6,.38,;7.34,1.16,;3.33,3.47,;2,2.7,;.67,3.47,;.67,5,;2,5.77,;3.33,5,;4.67,5.78,;-.67,2.69,;-.67,1.15,;-2,.38,;-3.33,1.15,;-3.33,2.69,;-2,3.46,;-2,5,;-2,-1.16,;-3.54,-1.16,;-.46,-1.16,;-2,-2.7,;-3.33,-3.47,;-3.33,-5.01,;-4.67,-5.78,;-6,-5.01,;-7.34,-5.78,;-8.67,-5.01,;-6,-3.47,;-4.67,-2.69,)| Show InChI InChI=1S/C25H30N4O3S/c1-16-3-8-22(33(31,32)29-21-6-4-18(15-30)5-7-21)13-23(16)20-12-24(25(26)28-14-20)19-9-10-27-17(2)11-19/h3,8-14,18,21,29-30H,4-7,15H2,1-2H3,(H2,26,28)/t18-,21-	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	30	n/a	n/a	n/a	n/a	7.5	25
Novartis AG US Patent					Assay Description The luminescence-based ATP detection reagent KinaseGlo was obtained from Promega, (Cat. No. V6714, Lot No. 236161) through Catalys, Wallisellen, Swit...				US Patent US10112926 (2018) BindingDB Entry DOI: 10.7270/Q22R3TQ9
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha (Homo sapiens (Human))	BDBM295239 (3-(6-amino-5-(2- methyloxazol-5- yl)pyridin-3-yl)-...) Show SMILES Cc1ncc(o1)-c1cc(cnc1N)-c1cc(ccc1C)S(=O)(=O)N[C@H]1CC[C@H](CO)CC1 |r,wU:27.30,wD:24.26,(6.06,1.93,;4.52,1.93,;3.61,.68,;2.15,1.15,;2.15,2.69,;3.61,3.17,;.82,3.47,;-.52,2.69,;-1.85,3.47,;-1.85,5,;-.52,5.78,;.82,5,;2.15,5.78,;-3.19,2.69,;-3.19,1.15,;-4.52,.38,;-5.85,1.15,;-5.85,2.69,;-4.52,3.47,;-4.52,5,;-4.52,-1.15,;-6.06,-1.15,;-2.98,-1.15,;-4.52,-2.69,;-3.19,-3.47,;-3.19,-5,;-1.85,-5.78,;-.52,-5,;.82,-5.78,;2.15,-5,;-.52,-3.47,;-1.85,-2.69,)| Show InChI InChI=1S/C23H28N4O4S/c1-14-3-8-19(32(29,30)27-18-6-4-16(13-28)5-7-18)10-20(14)17-9-21(23(24)26-11-17)22-12-25-15(2)31-22/h3,8-12,16,18,27-28H,4-7,13H2,1-2H3,(H2,24,26)/t16-,18-	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	30	n/a	n/a	n/a	n/a	7.5	25
Novartis AG US Patent					Assay Description The luminescence-based ATP detection reagent KinaseGlo was obtained from Promega, (Cat. No. V6714, Lot No. 236161) through Catalys, Wallisellen, Swit...				US Patent US10112926 (2018) BindingDB Entry DOI: 10.7270/Q22R3TQ9
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha (Homo sapiens (Human))	BDBM318958 (N-(5-(2,6-dimorpholinopyrimidin-4-yl)-4-(trifluoro...) Show SMILES CC(=O)Nc1cc(c(cn1)-c1cc(nc(n1)N1CCOCC1)N1CCOCC1)C(F)(F)F Show InChI InChI=1S/C20H23F3N6O3/c1-13(30)25-17-10-15(20(21,22)23)14(12-24-17)16-11-18(28-2-6-31-7-3-28)27-19(26-16)29-4-8-32-9-5-29/h10-12H,2-9H2,1H3,(H,24,25,30)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	32	n/a	n/a	n/a	n/a	n/a	n/a
Teligene Ltd. US Patent					Assay Description An in vitro assay which determines the ability of a test compound to inhibit PI3K alpha activity: PI3 delta (PIK3CD) kinase-tagged T7 phage strains w...				US Patent US10173995 (2019) BindingDB Entry DOI: 10.7270/Q2H70HX0
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha (Homo sapiens (Human))	BDBM50427453 (CHEMBL2322228 | US10308662, Compound 28 | US950578...) Show SMILES O=c1cc(oc2c(csc12)-c1ccc2OCCOc2c1)N1CCOCC1 Show InChI InChI=1S/C19H17NO5S/c21-14-10-17(20-3-5-22-6-4-20)25-18-13(11-26-19(14)18)12-1-2-15-16(9-12)24-8-7-23-15/h1-2,9-11H,3-8H2	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars	US Patent	n/a	n/a	34	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer					Assay Description Inhibitory activity can be determined routinely using known methods and also from commercial vendors offering this service for kinases and bromodomai...				J Med Chem 50: 2647-54 (2007) BindingDB Entry DOI: 10.7270/Q24170D7
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha (Homo sapiens (Human))	BDBM178430 (US9120812, 215) Show SMILES CCN1CC(C)(C)Oc2nc(nc(-c3ccc(NC(=O)Nc4ccc(cc4)C(=O)N(C)CCN(C)C)cc3)c2C1=O)N1CCOC[C@@H]1C |r| Show InChI InChI=1S/C35H46N8O5/c1-8-42-22-35(3,4)48-30-28(32(42)45)29(38-33(39-30)43-19-20-47-21-23(43)2)24-9-13-26(14-10-24)36-34(46)37-27-15-11-25(12-16-27)31(44)41(7)18-17-40(5)6/h9-16,23H,8,17-22H2,1-7H3,(H2,36,37,46)/t23-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	37	n/a	n/a	n/a	n/a	7.5	n/a
Sanofi US Patent					Assay Description The test uses a lucifeurerin/luciferase system to measure the concentration of ATP and its consumption during the enzymatic reaction. The test is per...				US Patent US9120812 (2015) BindingDB Entry DOI: 10.7270/Q2KH0M2D
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha (Homo sapiens (Human))	BDBM295065 (US10112926, Example 19 | trans 3-[6-Amino-5-(3-met...) Show SMILES Cc1noc(n1)-c1cc(cnc1N)-c1cc(ccc1C)S(=O)(=O)N[C@H]1CC[C@H](CO)CC1 |r,wU:24.26,wD:27.30,(5.5,-.1,;4.73,1.23,;5.2,2.69,;3.96,3.6,;2.71,2.69,;3.19,1.23,;1.38,3.47,;.04,2.69,;-1.29,3.47,;-1.29,5,;.04,5.78,;1.38,5,;2.71,5.78,;-2.62,2.69,;-2.62,1.15,;-3.96,.38,;-5.29,1.15,;-5.29,2.69,;-3.96,3.47,;-3.96,5,;-3.96,-1.15,;-2.42,-1.15,;-5.5,-1.15,;-3.96,-2.69,;-2.62,-3.47,;-1.29,-2.69,;.04,-3.47,;.04,-5,;1.38,-5.78,;2.71,-5,;-1.29,-5.78,;-2.62,-5,)| Show InChI InChI=1S/C22H27N5O4S/c1-13-3-8-18(32(29,30)27-17-6-4-15(12-28)5-7-17)10-19(13)16-9-20(21(23)24-11-16)22-25-14(2)26-31-22/h3,8-11,15,17,27-28H,4-7,12H2,1-2H3,(H2,23,24)/t15-,17-	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	40	n/a	n/a	n/a	n/a	7.5	25
Novartis AG US Patent					Assay Description The luminescence-based ATP detection reagent KinaseGlo was obtained from Promega, (Cat. No. V6714, Lot No. 236161) through Catalys, Wallisellen, Swit...				US Patent US10112926 (2018) BindingDB Entry DOI: 10.7270/Q22R3TQ9
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha (Homo sapiens (Human))	BDBM295053 (US10112926, Example 8.1 | US10112926, Example 8.2) Show SMILES Cc1noc(n1)-c1cc(cnc1N)-c1cc(ccc1C)S(=O)(=O)N[C@H]1CC2(C[C@H](O)C2)C1 |r,wU:24.26,28.31,(5.15,-7.55,;4.38,-6.22,;5.29,-4.97,;4.38,-3.73,;2.92,-4.2,;2.92,-5.74,;1.59,-3.43,;.25,-4.2,;-1.08,-3.43,;-1.08,-1.89,;.25,-1.12,;1.59,-1.89,;2.92,-1.12,;-2.42,-4.2,;-2.42,-5.74,;-3.75,-6.51,;-5.08,-5.74,;-5.08,-4.2,;-3.75,-3.43,;-3.75,-1.89,;-3.75,-8.05,;-2.21,-8.05,;-5.29,-8.05,;-3.75,-9.59,;-2.42,-10.36,;-.93,-9.97,;-.53,-11.45,;-.13,-12.94,;1.36,-12.54,;2.69,-13.31,;.96,-11.05,;-2.02,-11.85,)| Show InChI InChI=1S/C22H25N5O4S/c1-12-3-4-17(32(29,30)27-15-7-22(8-15)9-16(28)10-22)6-18(12)14-5-19(20(23)24-11-14)21-25-13(2)26-31-21/h3-6,11,15-16,27-28H,7-10H2,1-2H3,(H2,23,24)/t15-,16-,22?	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	40	n/a	n/a	n/a	n/a	7.5	25
Novartis AG US Patent					Assay Description The luminescence-based ATP detection reagent KinaseGlo was obtained from Promega, (Cat. No. V6714, Lot No. 236161) through Catalys, Wallisellen, Swit...				US Patent US10112926 (2018) BindingDB Entry DOI: 10.7270/Q22R3TQ9
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha (Homo sapiens (Human))	BDBM295144 (3-(6-Amino-5-(3-methyl-1,2,4-oxadiazol-5-yl)pyridi...) Show SMILES Cc1noc(n1)-c1cc(cnc1N)-c1cc(ccc1C)S(=O)(=O)NCCC1(O)CCCCC1 Show InChI InChI=1S/C23H29N5O4S/c1-15-6-7-18(33(30,31)26-11-10-23(29)8-4-3-5-9-23)13-19(15)17-12-20(21(24)25-14-17)22-27-16(2)28-32-22/h6-7,12-14,26,29H,3-5,8-11H2,1-2H3,(H2,24,25)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	50	n/a	n/a	n/a	n/a	7.5	25
Novartis AG US Patent					Assay Description The luminescence-based ATP detection reagent KinaseGlo was obtained from Promega, (Cat. No. V6714, Lot No. 236161) through Catalys, Wallisellen, Swit...				US Patent US10112926 (2018) BindingDB Entry DOI: 10.7270/Q22R3TQ9
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha (Homo sapiens (Human))	BDBM295159 (3-(6-Amino-5-(3-methyl-1,2,4-oxadiazol-5-yl)pyridi...) Show SMILES CCCONS(=O)(=O)c1ccc(C)c(c1)-c1cnc(N)c(c1)-c1nc(C)no1 Show InChI InChI=1S/C18H21N5O4S/c1-4-7-26-23-28(24,25)14-6-5-11(2)15(9-14)13-8-16(17(19)20-10-13)18-21-12(3)22-27-18/h5-6,8-10,23H,4,7H2,1-3H3,(H2,19,20)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	50	n/a	n/a	n/a	n/a	7.5	25
Novartis AG US Patent					Assay Description The luminescence-based ATP detection reagent KinaseGlo was obtained from Promega, (Cat. No. V6714, Lot No. 236161) through Catalys, Wallisellen, Swit...				US Patent US10112926 (2018) BindingDB Entry DOI: 10.7270/Q22R3TQ9
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha (Homo sapiens (Human))	BDBM315568 (US10172858, Table 2.65 | US9828378, # 65) Show SMILES CC(=O)N1CCC(CC1)n1nc(-c2cc3ccc(O)cc3[nH]2)c2c(N)ncnc12 Show InChI InChI=1S/C20H21N7O2/c1-11(28)26-6-4-13(5-7-26)27-20-17(19(21)22-10-23-20)18(25-27)16-8-12-2-3-14(29)9-15(12)24-16/h2-3,8-10,13,24,29H,4-7H2,1H3,(H2,21,22,23)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
INTELLIKINE LLC US Patent					Assay Description This assay is relatively simple, reasonably sensitive, and the peptide substrate can be adjusted both in terms of sequence and concentration to meet ...				US Patent US10172858 (2019) BindingDB Entry DOI: 10.7270/Q2736T01
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha (Homo sapiens (Human))	BDBM295247 (3-(6-amino-5-(2-methyloxazol-5-yl)pyridin-3-yl)-N-...) Show SMILES Cc1ncc(o1)-c1cc(cnc1N)-c1cc(ccc1C)S(=O)(=O)NOCC(C)(C)O Show InChI InChI=1S/C20H24N4O5S/c1-12-5-6-15(30(26,27)24-28-11-20(3,4)25)8-16(12)14-7-17(19(21)23-9-14)18-10-22-13(2)29-18/h5-10,24-25H,11H2,1-4H3,(H2,21,23)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	50	n/a	n/a	n/a	n/a	7.5	25
Novartis AG US Patent					Assay Description The luminescence-based ATP detection reagent KinaseGlo was obtained from Promega, (Cat. No. V6714, Lot No. 236161) through Catalys, Wallisellen, Swit...				US Patent US10112926 (2018) BindingDB Entry DOI: 10.7270/Q22R3TQ9
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha (Homo sapiens (Human))	BDBM295097 (3-(6-Amino-5-(2-methylthiazol-5-yl)pyridin-3-yl)-N...) Show SMILES Cc1ncc(s1)-c1cc(cnc1N)-c1cc(ccc1C)S(=O)(=O)NC1CC2(CC(O)C2)C1 |(9.15,-3.6,;7.61,-3.6,;6.7,-4.85,;5.24,-4.37,;5.24,-2.83,;6.7,-2.36,;3.91,-2.06,;2.57,-2.83,;1.24,-2.06,;1.24,-.52,;2.57,.25,;3.91,-.52,;5.24,.25,;-.1,-2.83,;-1.43,-2.06,;-2.76,-2.83,;-2.76,-4.37,;-1.43,-5.14,;-.1,-4.37,;1.24,-5.14,;-4.1,-2.06,;-4.1,-.52,;-4.87,-3.4,;-5.43,-1.29,;-6.2,.04,;-7.69,.44,;-7.29,1.92,;-6.89,3.41,;-8.38,3.81,;-9.15,5.14,;-8.78,2.32,;-5.8,1.53,)| Show InChI InChI=1S/C23H26N4O3S2/c1-13-3-4-18(32(29,30)27-16-7-23(8-16)9-17(28)10-23)6-19(13)15-5-20(22(24)26-11-15)21-12-25-14(2)31-21/h3-6,11-12,16-17,27-28H,7-10H2,1-2H3,(H2,24,26)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	50	n/a	n/a	n/a	n/a	7.5	25
Novartis AG US Patent					Assay Description The luminescence-based ATP detection reagent KinaseGlo was obtained from Promega, (Cat. No. V6714, Lot No. 236161) through Catalys, Wallisellen, Swit...				US Patent US10112926 (2018) BindingDB Entry DOI: 10.7270/Q22R3TQ9
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha (Homo sapiens (Human))	BDBM50427488 (CHEMBL2326956 | US10308662, Compound 100 | US95057...) Show SMILES OC(=O)c1ccc(cc1)-c1csc2c1oc(cc2=O)N1CCOCC1 Show InChI InChI=1S/C18H15NO5S/c20-14-9-15(19-5-7-23-8-6-19)24-16-13(10-25-17(14)16)11-1-3-12(4-2-11)18(21)22/h1-4,9-10H,5-8H2,(H,21,22)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	US Patent	n/a	n/a	55.2	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer					Assay Description Inhibitory activity can be determined routinely using known methods and also from commercial vendors offering this service for kinases and bromodomai...				J Med Chem 50: 2647-54 (2007) BindingDB Entry DOI: 10.7270/Q24170D7
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha (Homo sapiens (Human))	BDBM295052 (3-[6-Amino-5-(3-methyl-[1,2,4]oxadiazol-5-yl)-pyri...) Show SMILES Cc1noc(n1)-c1cc(cnc1N)-c1cc(ccc1C)S(=O)(=O)NC1CC2(CC(O)C2)C1 |(5.15,-.34,;4.38,1,;5.29,2.24,;4.38,3.49,;2.92,3.01,;2.92,1.47,;1.59,3.78,;.25,3.01,;-1.08,3.78,;-1.08,5.32,;.25,6.09,;1.59,5.32,;2.92,6.09,;-2.42,3.01,;-2.42,1.47,;-3.75,.7,;-5.08,1.47,;-5.08,3.01,;-3.75,3.78,;-3.75,5.32,;-3.75,-.84,;-2.21,-.84,;-5.29,-.84,;-3.75,-2.38,;-2.42,-3.15,;-2.02,-4.63,;-.53,-4.23,;-.13,-5.72,;1.36,-5.32,;2.69,-6.09,;.96,-3.84,;-.93,-2.75,)| Show InChI InChI=1S/C22H25N5O4S/c1-12-3-4-17(32(29,30)27-15-7-22(8-15)9-16(28)10-22)6-18(12)14-5-19(20(23)24-11-14)21-25-13(2)26-31-21/h3-6,11,15-16,27-28H,7-10H2,1-2H3,(H2,23,24)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	60	n/a	n/a	n/a	n/a	7.5	25
Novartis AG US Patent					Assay Description The luminescence-based ATP detection reagent KinaseGlo was obtained from Promega, (Cat. No. V6714, Lot No. 236161) through Catalys, Wallisellen, Swit...				US Patent US10112926 (2018) BindingDB Entry DOI: 10.7270/Q22R3TQ9
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha (Homo sapiens (Human))	BDBM295209 (5-(6-Amino-5-(3-methylisoxazol-5-yl)pyridin-3-yl)-...) Show SMILES Cc1cc(on1)-c1cc(cnc1N)-c1cc(c(Cl)cc1C)S(=O)(=O)NCC(C)(C)O Show InChI InChI=1S/C20H23ClN4O4S/c1-11-5-16(21)18(30(27,28)24-10-20(3,4)26)8-14(11)13-7-15(19(22)23-9-13)17-6-12(2)25-29-17/h5-9,24,26H,10H2,1-4H3,(H2,22,23)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	60	n/a	n/a	n/a	n/a	7.5	25
Novartis AG US Patent					Assay Description The luminescence-based ATP detection reagent KinaseGlo was obtained from Promega, (Cat. No. V6714, Lot No. 236161) through Catalys, Wallisellen, Swit...				US Patent US10112926 (2018) BindingDB Entry DOI: 10.7270/Q22R3TQ9
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha (Homo sapiens (Human))	BDBM319548 (US10173995, Compound 6) Show SMILES CCCNc1cc(c(cn1)-c1cc(nc(n1)N1CCOCC1)N1CCOCC1)C(F)(F)F Show InChI InChI=1S/C21H27F3N6O2/c1-2-3-25-18-12-16(21(22,23)24)15(14-26-18)17-13-19(29-4-8-31-9-5-29)28-20(27-17)30-6-10-32-11-7-30/h12-14H,2-11H2,1H3,(H,25,26)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	60	n/a	n/a	n/a	n/a	n/a	n/a
Teligene Ltd. US Patent					Assay Description An in vitro assay which determines the ability of a test compound to inhibit PI3K alpha activity: PI3 alpha (PIK3CA) kinase-tagged T7 phage strains w...				US Patent US10173995 (2019) BindingDB Entry DOI: 10.7270/Q2H70HX0
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha (Homo sapiens (Human))	BDBM295103 (3-(6-Amino-5-(1-(2,2,2-trifluoroethyl)-1H-pyrazol-...) Show SMILES Cc1ccc(cc1-c1cnc(N)c(c1)-c1cnn(CC(F)(F)F)c1)S(=O)(=O)NOCC(C)(C)O Show InChI InChI=1S/C21H24F3N5O4S/c1-13-4-5-16(34(31,32)28-33-12-20(2,3)30)7-17(13)14-6-18(19(25)26-8-14)15-9-27-29(10-15)11-21(22,23)24/h4-10,28,30H,11-12H2,1-3H3,(H2,25,26)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	70	n/a	n/a	n/a	n/a	7.5	25
Novartis AG US Patent					Assay Description The luminescence-based ATP detection reagent KinaseGlo was obtained from Promega, (Cat. No. V6714, Lot No. 236161) through Catalys, Wallisellen, Swit...				US Patent US10112926 (2018) BindingDB Entry DOI: 10.7270/Q22R3TQ9
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha (Homo sapiens (Human))	BDBM295089 (US10112926, Example 21b) Show SMILES Cc1cc(on1)-c1cc(cnc1N)-c1cc(ccc1C)S(=O)(=O)NO[C@@H]1CCOC1 |r| Show InChI InChI=1S/C20H22N4O5S/c1-12-3-4-16(30(25,26)24-28-15-5-6-27-11-15)9-17(12)14-8-18(20(21)22-10-14)19-7-13(2)23-29-19/h3-4,7-10,15,24H,5-6,11H2,1-2H3,(H2,21,22)/t15-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	70	n/a	n/a	n/a	n/a	7.5	25
Novartis AG US Patent					Assay Description The luminescence-based ATP detection reagent KinaseGlo was obtained from Promega, (Cat. No. V6714, Lot No. 236161) through Catalys, Wallisellen, Swit...				US Patent US10112926 (2018) BindingDB Entry DOI: 10.7270/Q22R3TQ9
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha (Homo sapiens (Human))	BDBM295057 (3-[6-Amino-5-(3-methyl-[1,2,4]oxadiazol-5-yl)-pyri...) Show SMILES Cc1noc(n1)-c1cc(cnc1N)-c1cc(ccc1C)S(=O)(=O)NOCC(C)(C)O Show InChI InChI=1S/C19H23N5O5S/c1-11-5-6-14(30(26,27)24-28-10-19(3,4)25)8-15(11)13-7-16(17(20)21-9-13)18-22-12(2)23-29-18/h5-9,24-25H,10H2,1-4H3,(H2,20,21)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	70	n/a	n/a	n/a	n/a	7.5	25
Novartis AG US Patent					Assay Description The luminescence-based ATP detection reagent KinaseGlo was obtained from Promega, (Cat. No. V6714, Lot No. 236161) through Catalys, Wallisellen, Swit...				US Patent US10112926 (2018) BindingDB Entry DOI: 10.7270/Q22R3TQ9
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha (Homo sapiens (Human))	BDBM295129 (3-(6-Amino-5-(3-methylisoxazol-5-yl)pyridin-3-yl)-...) Show SMILES Cc1cc(on1)-c1cc(cnc1N)-c1cc(ccc1C)S(=O)(=O)NCCC1(O)CCCC1 Show InChI InChI=1S/C23H28N4O4S/c1-15-5-6-18(32(29,30)26-10-9-23(28)7-3-4-8-23)13-19(15)17-12-20(22(24)25-14-17)21-11-16(2)27-31-21/h5-6,11-14,26,28H,3-4,7-10H2,1-2H3,(H2,24,25)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	70	n/a	n/a	n/a	n/a	7.5	25
Novartis AG US Patent					Assay Description The luminescence-based ATP detection reagent KinaseGlo was obtained from Promega, (Cat. No. V6714, Lot No. 236161) through Catalys, Wallisellen, Swit...				US Patent US10112926 (2018) BindingDB Entry DOI: 10.7270/Q22R3TQ9
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha (Homo sapiens (Human))	BDBM178238 (US9120812, 23) Show SMILES CCN1CC(C)(C)Oc2nc(nc(-c3ccc(NC(=O)Nc4ccc(cc4)C(=O)N4CCC(CC4)N(C)C)cc3)c2C1=O)N1CCOC[C@@H]1C |r| Show InChI InChI=1S/C37H48N8O5/c1-7-43-23-37(3,4)50-32-30(34(43)47)31(40-35(41-32)45-20-21-49-22-24(45)2)25-8-12-27(13-9-25)38-36(48)39-28-14-10-26(11-15-28)33(46)44-18-16-29(17-19-44)42(5)6/h8-15,24,29H,7,16-23H2,1-6H3,(H2,38,39,48)/t24-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	79	n/a	n/a	n/a	n/a	7.5	n/a
Sanofi US Patent					Assay Description The test uses a lucifeurerin/luciferase system to measure the concentration of ATP and its consumption during the enzymatic reaction. The test is per...				US Patent US9120812 (2015) BindingDB Entry DOI: 10.7270/Q2KH0M2D
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha (Homo sapiens (Human))	BDBM295257 (3-(6-amino-5-(2- methyloxazol-5- yl)pyridin-3-yl)-...) Show SMILES Cc1ncc(o1)-c1cc(cnc1N)-c1cc(ccc1C)S(=O)(=O)NC1CCC(O)(C1)C(F)(F)F Show InChI InChI=1S/C22H23F3N4O4S/c1-12-3-4-16(34(31,32)29-15-5-6-21(30,9-15)22(23,24)25)8-17(12)14-7-18(20(26)28-10-14)19-11-27-13(2)33-19/h3-4,7-8,10-11,15,29-30H,5-6,9H2,1-2H3,(H2,26,28)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	80	n/a	n/a	n/a	n/a	7.5	25
Novartis AG US Patent					Assay Description The luminescence-based ATP detection reagent KinaseGlo was obtained from Promega, (Cat. No. V6714, Lot No. 236161) through Catalys, Wallisellen, Swit...				US Patent US10112926 (2018) BindingDB Entry DOI: 10.7270/Q22R3TQ9
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha (Homo sapiens (Human))	BDBM295087 (3-(6-Amino-5-(3-methylisoxazol-5-yl)pyridin-3-yl)-...) Show SMILES Cc1cc(on1)-c1cc(cnc1N)-c1cc(ccc1C)S(=O)(=O)NOCC(C)(C)O Show InChI InChI=1S/C20H24N4O5S/c1-12-5-6-15(30(26,27)24-28-11-20(3,4)25)9-16(12)14-8-17(19(21)22-10-14)18-7-13(2)23-29-18/h5-10,24-25H,11H2,1-4H3,(H2,21,22)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	80	n/a	n/a	n/a	n/a	7.5	25
Novartis AG US Patent					Assay Description The luminescence-based ATP detection reagent KinaseGlo was obtained from Promega, (Cat. No. V6714, Lot No. 236161) through Catalys, Wallisellen, Swit...				US Patent US10112926 (2018) BindingDB Entry DOI: 10.7270/Q22R3TQ9
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha (Homo sapiens (Human))	BDBM295042 (3-[6-Amino-5-(3-methyl-[1,2,4]oxadiazol-5-yl)-pyri...) Show SMILES Cc1noc(n1)-c1cc(cnc1N)-c1cc(ccc1C)S(=O)(=O)NCCC(C)(C)O Show InChI InChI=1S/C20H25N5O4S/c1-12-5-6-15(30(27,28)23-8-7-20(3,4)26)10-16(12)14-9-17(18(21)22-11-14)19-24-13(2)25-29-19/h5-6,9-11,23,26H,7-8H2,1-4H3,(H2,21,22)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	80	n/a	n/a	n/a	n/a	7.5	25
Novartis AG US Patent					Assay Description The luminescence-based ATP detection reagent KinaseGlo was obtained from Promega, (Cat. No. V6714, Lot No. 236161) through Catalys, Wallisellen, Swit...				US Patent US10112926 (2018) BindingDB Entry DOI: 10.7270/Q22R3TQ9
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha (Homo sapiens (Human))	BDBM178392 (US9120812, 177) Show SMILES CCN1CC(C)(C)Oc2nc(nc(-c3ccc(NC(=O)Nc4ccc(cc4)C(=O)N4CCC(CC4)N(C)C)cc3)c2C1=O)N1CC2CCC(C1)O2 |TLB:10:43:46.47:50| Show InChI InChI=1S/C38H48N8O5/c1-6-44-23-38(2,3)51-33-31(35(44)48)32(41-36(42-33)46-21-29-15-16-30(22-46)50-29)24-7-11-26(12-8-24)39-37(49)40-27-13-9-25(10-14-27)34(47)45-19-17-28(18-20-45)43(4)5/h7-14,28-30H,6,15-23H2,1-5H3,(H2,39,40,49)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	87	n/a	n/a	n/a	n/a	7.5	n/a
Sanofi US Patent					Assay Description The test uses a lucifeurerin/luciferase system to measure the concentration of ATP and its consumption during the enzymatic reaction. The test is per...				US Patent US9120812 (2015) BindingDB Entry DOI: 10.7270/Q2KH0M2D
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha (Homo sapiens (Human))	BDBM259879 (US10308662, Compound 118 | US9505780, 118) Show SMILES ONC(=O)c1ccc(cc1)-c1csc2c1oc(cc2=O)N1CCOCC1 Show InChI InChI=1S/C18H16N2O5S/c21-14-9-15(20-5-7-24-8-6-20)25-16-13(10-26-17(14)16)11-1-3-12(4-2-11)18(22)19-23/h1-4,9-10,23H,5-8H2,(H,19,22)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid PDB UniChem	US Patent	n/a	n/a	90	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer					Assay Description Inhibitory activity can be determined routinely using known methods and also from commercial vendors offering this service for kinases and bromodomai...				J Med Chem 50: 2647-54 (2007) BindingDB Entry DOI: 10.7270/Q24170D7
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha (Homo sapiens (Human))	BDBM295064 (3-(2-Amino-[3,4′]bipyridinyl-5-yl)-N-(3-hydr...) Show SMILES Cc1ccc(cc1-c1cnc(N)c(c1)-c1ccncc1)S(=O)(=O)NCCC(C)(C)O Show InChI InChI=1S/C22H26N4O3S/c1-15-4-5-18(30(28,29)26-11-8-22(2,3)27)13-19(15)17-12-20(21(23)25-14-17)16-6-9-24-10-7-16/h4-7,9-10,12-14,26-27H,8,11H2,1-3H3,(H2,23,25)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	90	n/a	n/a	n/a	n/a	7.5	25
Novartis AG US Patent					Assay Description The luminescence-based ATP detection reagent KinaseGlo was obtained from Promega, (Cat. No. V6714, Lot No. 236161) through Catalys, Wallisellen, Swit...				US Patent US10112926 (2018) BindingDB Entry DOI: 10.7270/Q22R3TQ9
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha (Homo sapiens (Human))	BDBM295170 (US10112926, Example 55 | trans-3-(6-Amino-5-(3-met...) Show SMILES Cc1noc(n1)-c1cc(cnc1N)-c1cc(ccc1C)S(=O)(=O)NO[C@H]1C[C@H](O)C1 |r,wU:27.30,wD:25.27,(7.68,-1.27,;6.91,.07,;7.81,1.31,;6.91,2.56,;5.45,2.08,;5.45,.54,;4.11,2.85,;2.78,2.08,;1.44,2.85,;1.44,4.39,;2.78,5.16,;4.11,4.39,;5.45,5.16,;.11,2.08,;.11,.54,;-1.22,-.23,;-2.56,.54,;-2.56,2.08,;-1.22,2.85,;-1.22,4.39,;-1.22,-1.77,;.32,-1.77,;-2.76,-1.77,;-1.22,-3.31,;-2.56,-4.08,;-4.1,-4.08,;-5.19,-2.99,;-6.27,-4.08,;-7.81,-4.08,;-5.19,-5.16,)| Show InChI InChI=1S/C19H21N5O5S/c1-10-3-4-15(30(26,27)24-28-14-6-13(25)7-14)8-16(10)12-5-17(18(20)21-9-12)19-22-11(2)23-29-19/h3-5,8-9,13-14,24-25H,6-7H2,1-2H3,(H2,20,21)/t13-,14-	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	90	n/a	n/a	n/a	n/a	7.5	25
Novartis AG US Patent					Assay Description The luminescence-based ATP detection reagent KinaseGlo was obtained from Promega, (Cat. No. V6714, Lot No. 236161) through Catalys, Wallisellen, Swit...				US Patent US10112926 (2018) BindingDB Entry DOI: 10.7270/Q22R3TQ9
					More data for this Ligand-Target Pair

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