Found 41 hits of ic50 data for polymerid = 50006394 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Ubiquitin carboxyl-terminal hydrolase 2
(Homo sapiens (Human)) | BDBM50608544
(CHEMBL3392741) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| UniChem
| | n/a | n/a | 1.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Ubiquitin carboxyl-terminal hydrolase 2
(Homo sapiens (Human)) | BDBM50458422
(CHEMBL4216958)Show SMILES NC(=O)c1c(NC(=O)COCc2cc(on2)-c2cccs2)sc2CCCCc12 Show InChI InChI=1S/C19H19N3O4S2/c20-18(24)17-12-4-1-2-5-14(12)28-19(17)21-16(23)10-25-9-11-8-13(26-22-11)15-6-3-7-27-15/h3,6-8H,1-2,4-5,9-10H2,(H2,20,24)(H,21,23) | PDB MMDB
KEGG
UniProtKB/SwissProt
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MCE PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 3.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Jagiellonian University
Curated by ChEMBL
| Assay Description Inhibition of human USP2a (258 to 605 residues) expressed in Escherichia coli BL21(DE3) using Ub-AMC as substrate incubated for 30 mins measured at 3... |
Eur J Med Chem 150: 261-267 (2018)
Article DOI: 10.1016/j.ejmech.2018.03.009 BindingDB Entry DOI: 10.7270/Q28G8P98 |
More data for this Ligand-Target Pair | |
Ubiquitin carboxyl-terminal hydrolase 2
(Homo sapiens (Human)) | BDBM50591324
(CHEMBL5185273)Show SMILES CN1CC[C@H](C1)Oc1ccc(F)c(-c2nc3c(o2)C(=O)c2ccccc2C3=O)c1Cl |r| | PDB MMDB
KEGG
UniProtKB/SwissProt
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MCE PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 3.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c00408 BindingDB Entry DOI: 10.7270/Q25H7M81 |
More data for this Ligand-Target Pair | |
Ubiquitin carboxyl-terminal hydrolase 2
(Homo sapiens (Human)) | BDBM50591321
(CHEMBL5172138) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| Purchase
MCE PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 5.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c00408 BindingDB Entry DOI: 10.7270/Q25H7M81 |
More data for this Ligand-Target Pair | |
Ubiquitin carboxyl-terminal hydrolase 2
(Homo sapiens (Human)) | BDBM50591322
(CHEMBL5196686)Show SMILES CN1CC[C@H](C1)Oc1ccc(Cl)c(c1)-c1nc2c(o1)C(=O)c1ccccc1C2=O |r| | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 6.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c00408 BindingDB Entry DOI: 10.7270/Q25H7M81 |
More data for this Ligand-Target Pair | |
Ubiquitin carboxyl-terminal hydrolase 2
(Homo sapiens (Human)) | BDBM50458415
(CHEMBL567508 | EN300-02284)Show InChI InChI=1S/C9H12N2OS/c10-8(12)7-5-3-1-2-4-6(5)13-9(7)11/h1-4,11H2,(H2,10,12) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
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MCE PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 8.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Jagiellonian University
Curated by ChEMBL
| Assay Description Inhibition of human USP2a (258 to 605 residues) expressed in Escherichia coli BL21(DE3) using Ub-AMC as substrate incubated for 30 mins measured at 3... |
Eur J Med Chem 150: 261-267 (2018)
Article DOI: 10.1016/j.ejmech.2018.03.009 BindingDB Entry DOI: 10.7270/Q28G8P98 |
More data for this Ligand-Target Pair | |
Ubiquitin carboxyl-terminal hydrolase 2
(Homo sapiens (Human)) | BDBM50514116
(CHEMBL4458718)Show SMILES [H][C@@]1(CC[C@]2([H])[C@]1(C)CC[C@@]1([H])[C@@]2(C)CC[C@]2([H])C[C@H](O)CC[C@]12C)[C@H](C)CCC(=O)NO |r| Show InChI InChI=1S/C25H43NO3/c1-16(5-8-22(28)26-29)19-6-7-20-24(19,3)14-11-21-23(2)13-10-18(27)15-17(23)9-12-25(20,21)4/h16-21,27,29H,5-15H2,1-4H3,(H,26,28)/t16-,17-,18-,19-,20-,21-,23+,24-,25+/m1/s1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 9.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Dana-Farber Cancer Institute
Curated by ChEMBL
| Assay Description Inhibition of USP2 (unknown origin) using Ub-AMC substrate |
J Med Chem 63: 2731-2750 (2020)
Article DOI: 10.1021/acs.jmedchem.9b01138 BindingDB Entry DOI: 10.7270/Q2GF0XTC |
More data for this Ligand-Target Pair | |
Ubiquitin carboxyl-terminal hydrolase 2
(Homo sapiens (Human)) | BDBM50538571
(CHEMBL4635160)Show SMILES C[C@H]1CNCC[C@H]1Oc1c(C)cc(Cl)cc1-c1ccnc2cc(CN3C(=O)C4C(C3=O)C4(C)C)sc12 |r| Show InChI InChI=1S/C28H30ClN3O3S/c1-14-9-16(29)10-19(24(14)35-21-6-7-30-12-15(21)2)18-5-8-31-20-11-17(36-25(18)20)13-32-26(33)22-23(27(32)34)28(22,3)4/h5,8-11,15,21-23,30H,6-7,12-13H2,1-4H3/t15-,21+,22?,23?/m0/s1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
RAPT Therapeutics, Inc.
Curated by ChEMBL
| Assay Description Inhibition of human GST-tagged USP2 isoform 4 expressed in Escherichia coli assessed as cleavage of Ubiquitin-Rhodamine110-glycine to Ubiquitin and R... |
J Med Chem 63: 5398-5420 (2020)
Article DOI: 10.1021/acs.jmedchem.0c00245 BindingDB Entry DOI: 10.7270/Q2XK8K2T |
More data for this Ligand-Target Pair | |
Ubiquitin carboxyl-terminal hydrolase 2
(Homo sapiens (Human)) | BDBM50591323
(CHEMBL5173239)Show SMILES CN1CC[C@H](C1)Oc1ccc(Cl)c(-c2nc3c(o2)C(=O)c2ccccc2C3=O)c1F |r| | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c00408 BindingDB Entry DOI: 10.7270/Q25H7M81 |
More data for this Ligand-Target Pair | |
Ubiquitin carboxyl-terminal hydrolase 2
(Homo sapiens (Human)) | BDBM50442907
(Acetyl Isogambogic Acid | CHEMBL3039433)Show SMILES [H]C12[#6]-[#6@H]-3-[#6]=[#6]4-[#6](=O)-c5c(-[#8]-[#6](-[#6])=O)c6-[#6]=[#6]C([#6])([#6]-[#6]\[#6]=[#6](\[#6])-[#6])[#8]-c6c(-[#6]\[#6]=[#6](\[#6])-[#6])c5-[#8][C@@]14C([#6]\[#6]=[#6](/[#6])-[#6](-[#8])=O)([#8]C2([#6])[#6])[#6]-3=O |r,c:15,t:4,TLB:34:35:44.45:48.3.2,4:3:35:44.45,THB:5:35:44.45:48.3.2,49:48:35:44.45,45:1:5.4:36.48| Show InChI InChI=1S/C40H46O9/c1-21(2)11-10-16-38(9)17-15-27-32(47-38)26(13-12-22(3)4)34-30(33(27)46-24(6)41)31(42)28-19-25-20-29-37(7,8)49-39(35(25)43,40(28,29)48-34)18-14-23(5)36(44)45/h11-12,14-15,17,19,25,29H,10,13,16,18,20H2,1-9H3,(H,44,45)/b23-14+/t25-,29?,38?,39?,40-/m1/s1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.82E+4 | n/a | n/a | n/a | n/a | 7.5 | 25 |
University of Delaware
| Assay Description Ubiquitin-7-amino-4-methylcoumarin (Ub-AMC) was generated as previously described.(7) The enzymatic reaction was conducted in fluorometric assay buff... |
ACS Chem Biol 12: 2399-2407 (2017)
Article DOI: 10.1021/acschembio.7b00543 BindingDB Entry DOI: 10.7270/Q21J97WD |
More data for this Ligand-Target Pair | |
Ubiquitin carboxyl-terminal hydrolase 2
(Homo sapiens (Human)) | BDBM200235
(Rifampicin | cid_5381226)Show SMILES CO[C@H]1\C=C\O[C@@]2(C)Oc3c(C2=O)c2C(=O)\C(=C\NN4CCN(C)CC4)C(NC(=O)\C(C)=C/C=C/[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@@H]1C)=C(O)c2c(O)c3C |wU:45.47,41.43,37.39,43.45,35.37,6.6,wD:2.1,39.41,50.53,c:33,t:3,35,54,(15.1,-5.61,;13.64,-5.11,;13.35,-3.6,;14.73,-2.92,;16.01,-3.78,;17.39,-3.1,;17.5,-1.56,;18.99,-1.94,;18.12,-.17,;16.98,.86,;15.65,.09,;15.97,-1.41,;16.45,-2.87,;14.32,.86,;12.94,.04,;14.28,-.72,;11.54,.83,;10.21,.05,;9.44,1.38,;9.43,2.92,;8.1,3.69,;8.09,5.23,;9.42,6,;9.42,7.54,;10.76,5.24,;10.76,3.7,;11.54,2.43,;10.16,1.76,;9.14,.62,;9.33,-.91,;7.86,1.48,;7.43,2.96,;6.47,.8,;6.37,-.73,;4.99,-1.41,;4.49,-2.87,;3.08,-2.24,;5.5,-4.03,;4.48,-5.18,;7.04,-4.13,;6.8,-5.65,;7.9,-2.85,;7.67,-1.33,;9.41,-2.56,;10.9,-2.2,;10.69,-3.42,;10.98,-4.93,;10.48,-6.38,;11.5,-7.54,;8.97,-6.68,;12.07,-2.74,;13.58,-2.44,;12.94,3.22,;12.96,4.76,;14.32,2.4,;15.65,3.17,;15.65,4.71,;16.98,2.4,;18.32,3.17,)| Show InChI InChI=1S/C43H58N4O12/c1-21-12-11-13-22(2)42(55)45-33-28(20-44-47-17-15-46(9)16-18-47)37(52)30-31(38(33)53)36(51)26(6)40-32(30)41(54)43(8,59-40)57-19-14-29(56-10)23(3)39(58-27(7)48)25(5)35(50)24(4)34(21)49/h11-14,19-21,23-25,29,34-35,39,44,49-51,53H,15-18H2,1-10H3,(H,45,55)/b12-11+,19-14+,22-13-,28-20+/t21-,23+,24+,25+,29-,34-,35+,39+,43-/m0/s1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
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PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 2.12E+4 | n/a | n/a | n/a | n/a | 7.5 | 25 |
University of Delaware
| Assay Description Ubiquitin-7-amino-4-methylcoumarin (Ub-AMC) was generated as previously described.(7) The enzymatic reaction was conducted in fluorometric assay buff... |
ACS Chem Biol 12: 2399-2407 (2017)
Article DOI: 10.1021/acschembio.7b00543 BindingDB Entry DOI: 10.7270/Q21J97WD |
More data for this Ligand-Target Pair | |
Ubiquitin carboxyl-terminal hydrolase 2
(Homo sapiens (Human)) | BDBM217379
(CDDO-Me, 2)Show SMILES COC(=O)[C@]12CCC(C)(C)C[C@H]1[C@H]1C(=O)C=C3[C@@]4(C)C=C(C#N)C(=O)C(C)(C)[C@@H]4CC[C@@]3(C)[C@]1(C)CC2 |r,t:16,20| Show InChI InChI=1S/C32H43NO4/c1-27(2)11-13-32(26(36)37-8)14-12-31(7)24(20(32)17-27)21(34)15-23-29(5)16-19(18-33)25(35)28(3,4)22(29)9-10-30(23,31)6/h15-16,20,22,24H,9-14,17H2,1-8H3/t20-,22-,24-,29-,30+,31+,32-/m0/s1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
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MCE PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 2.20E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Progenra, Inc.
Curated by ChEMBL
| Assay Description Inhibition of USP2 (unknown origin) |
J Med Chem 61: 422-443 (2018)
Article DOI: 10.1021/acs.jmedchem.7b00498 BindingDB Entry DOI: 10.7270/Q2CR5WVG |
More data for this Ligand-Target Pair | |
Ubiquitin carboxyl-terminal hydrolase 2
(Homo sapiens (Human)) | BDBM50612980
(CHEMBL5275910) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| UniChem
| | n/a | n/a | >2.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Ubiquitin carboxyl-terminal hydrolase 2
(Homo sapiens (Human)) | BDBM50612981
(CHEMBL5275560) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| UniChem
| | n/a | n/a | >2.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Ubiquitin carboxyl-terminal hydrolase 2
(Homo sapiens (Human)) | BDBM50612979
(CHEMBL5274527) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| UniChem
| | n/a | n/a | >2.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Ubiquitin carboxyl-terminal hydrolase 2
(Homo sapiens (Human)) | BDBM50612978
(CHEMBL5269199) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| UniChem
| | n/a | n/a | >2.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Ubiquitin carboxyl-terminal hydrolase 2
(Homo sapiens (Human)) | BDBM50612977
(CHEMBL5278034) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| UniChem
| | n/a | n/a | >2.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Ubiquitin carboxyl-terminal hydrolase 2
(Homo sapiens (Human)) | BDBM50612976
(CHEMBL5266959) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| UniChem
| | n/a | n/a | >2.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Ubiquitin carboxyl-terminal hydrolase 2
(Homo sapiens (Human)) | BDBM50612975
(CHEMBL5269490) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| UniChem
| | n/a | n/a | >2.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Ubiquitin carboxyl-terminal hydrolase 2
(Homo sapiens (Human)) | BDBM50612974
(CHEMBL5269090) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| UniChem
| | n/a | n/a | 2.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Ubiquitin carboxyl-terminal hydrolase 2
(Homo sapiens (Human)) | BDBM50612973
(CHEMBL5266408) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| UniChem
| | n/a | n/a | >2.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Ubiquitin carboxyl-terminal hydrolase 2
(Homo sapiens (Human)) | BDBM50612972
(CHEMBL5271797) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| UniChem
| | n/a | n/a | >2.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Ubiquitin carboxyl-terminal hydrolase 2
(Homo sapiens (Human)) | BDBM50612971
(CHEMBL5273043) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| UniChem
| | n/a | n/a | >2.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Ubiquitin carboxyl-terminal hydrolase 2
(Homo sapiens (Human)) | BDBM205457
((2R,4aS,6aR,6aS,14aS,14bR)-10-hydroxy-2,4a,6a,6a,9...)Show SMILES CC1=C(O)C(=O)C=C2C1=CC=C1[C@@]2(C)CC[C@@]2(C)[C@@H]3C[C@@](C)(CC[C@]3(C)CC[C@]12C)C(O)=O |r,c:1,6,11,t:9| Show InChI InChI=1S/C29H38O4/c1-17-18-7-8-21-27(4,19(18)15-20(30)23(17)31)12-14-29(6)22-16-26(3,24(32)33)10-9-25(22,2)11-13-28(21,29)5/h7-8,15,22,31H,9-14,16H2,1-6H3,(H,32,33)/t22-,25-,26-,27+,28-,29+/m1/s1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
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MCE PC cid PC sid PDB UniChem
| Article PubMed
| n/a | n/a | 2.87E+4 | n/a | n/a | n/a | n/a | 7.5 | 25 |
University of Delaware
| Assay Description Ubiquitin-7-amino-4-methylcoumarin (Ub-AMC) was generated as previously described.(7) The enzymatic reaction was conducted in fluorometric assay buff... |
ACS Chem Biol 12: 2399-2407 (2017)
Article DOI: 10.1021/acschembio.7b00543 BindingDB Entry DOI: 10.7270/Q21J97WD |
More data for this Ligand-Target Pair | |
Ubiquitin carboxyl-terminal hydrolase 2
(Homo sapiens (Human)) | BDBM50436152
(SPONGIACIDIN C)Show InChI InChI=1S/C11H10N4O3/c16-9-7-5(1-3-12-7)6(2-4-13-9)8-10(17)15-11(18)14-8/h1,3,12H,2,4H2,(H,13,16)(H2,14,15,17,18)/b8-6- | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | >3.16E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Kumamoto University
Curated by ChEMBL
| Assay Description Inhibition of core catalytic domain of USP2 (unknown origin) using diubiquitin IQF K4804 as substrate |
Bioorg Med Chem Lett 23: 3884-6 (2013)
Article DOI: 10.1016/j.bmcl.2013.04.066 BindingDB Entry DOI: 10.7270/Q29P332K |
More data for this Ligand-Target Pair | |
Ubiquitin carboxyl-terminal hydrolase 2
(Homo sapiens (Human)) | BDBM50072959
(CHEMBL3410535)Show SMILES [O-][N+](=O)c1ccc(\C=C2/CS(=O)(=O)C\C(=C/c3ccc(cc3)[N+]([O-])=O)C2=O)cc1 Show InChI InChI=1S/C19H14N2O7S/c22-19-15(9-13-1-5-17(6-2-13)20(23)24)11-29(27,28)12-16(19)10-14-3-7-18(8-4-14)21(25)26/h1-10H,11-12H2/b15-9+,16-10+ | PDB MMDB
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CHEMBL MCE PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 3.26E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Trieste
Curated by ChEMBL
| Assay Description Inhibition of USP2 catalytic domain (unknown origin) expressed in bacteria using Ub-AMC as substrate preincubated for 30 mins before substrate additi... |
J Med Chem 58: 1691-704 (2015)
Article DOI: 10.1021/jm501336h BindingDB Entry DOI: 10.7270/Q2J67JM0 |
More data for this Ligand-Target Pair | |
Ubiquitin carboxyl-terminal hydrolase 2
(Homo sapiens (Human)) | BDBM50200099
(2-Amino-1,7-dihydro-purine-6-thione | 2-Amino-1,9-...)Show InChI InChI=1S/C5H5N5S/c6-5-9-3-2(4(11)10-5)7-1-8-3/h1H,(H4,6,7,8,9,10,11) | PDB MMDB
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| | n/a | n/a | 4.20E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
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Citation and Details
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More data for this Ligand-Target Pair | |
Ubiquitin carboxyl-terminal hydrolase 2
(Homo sapiens (Human)) | BDBM50597468
(CHEMBL5184337)Show SMILES Cc1n[nH]c(C)c1Oc1c(O)cc(O)c2c1oc(cc2=O)-c1ccc(cc1)N1CCN(CC1)c1ccccn1 | PDB MMDB
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| n/a | n/a | 5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
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Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c00013 BindingDB Entry DOI: 10.7270/Q2ST7TW8 |
More data for this Ligand-Target Pair | |
Ubiquitin carboxyl-terminal hydrolase 2
(Homo sapiens (Human)) | BDBM50458419
(CHEMBL4203286)Show InChI InChI=1S/C18H14N2O4S/c1-12(23-15-6-4-13(10-19)5-7-15)18(21)22-11-14-9-16(24-20-14)17-3-2-8-25-17/h2-9,12H,11H2,1H3 | PDB MMDB
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| n/a | n/a | >5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Jagiellonian University
Curated by ChEMBL
| Assay Description Inhibition of human USP2a (258 to 605 residues) expressed in Escherichia coli BL21(DE3) using Ub-AMC as substrate incubated for 30 mins measured at 3... |
Eur J Med Chem 150: 261-267 (2018)
Article DOI: 10.1016/j.ejmech.2018.03.009 BindingDB Entry DOI: 10.7270/Q28G8P98 |
More data for this Ligand-Target Pair | |
Ubiquitin carboxyl-terminal hydrolase 2
(Homo sapiens (Human)) | BDBM50269827
(CHEMBL4089822)Show SMILES CC(=O)Nc1cccc(CNC(=O)c2sc3ccccc3c2OCc2ccccc2)c1 Show InChI InChI=1S/C25H22N2O3S/c1-17(28)27-20-11-7-10-19(14-20)15-26-25(29)24-23(21-12-5-6-13-22(21)31-24)30-16-18-8-3-2-4-9-18/h2-14H,15-16H2,1H3,(H,26,29)(H,27,28) | PDB MMDB
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| n/a | n/a | 6.61E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
State Key Laboratory of Microbial Metabolism, School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, China.
Curated by ChEMBL
| Assay Description Inhibition of recombinant human N-terminal His-tagged USP2 catalytic domain (258 to 605 residues) expressed in Escherichia coli BL21(DE3) using human... |
Bioorg Med Chem Lett 27: 4015-4018 (2017)
Article DOI: 10.1016/j.bmcl.2017.07.059 BindingDB Entry DOI: 10.7270/Q2GQ718V |
More data for this Ligand-Target Pair | |
Ubiquitin carboxyl-terminal hydrolase 2
(Homo sapiens (Human)) | BDBM50242207
(CHEMBL455364 | Mangiferin)Show SMILES OC[C@H]1O[C@@H](Oc2c(O)cc3oc4cc(O)c(O)cc4c(=O)c3c2O)[C@H](O)[C@@H](O)[C@@H]1O |r| Show InChI InChI=1S/C19H18O12/c20-4-11-14(25)16(27)17(28)19(30-11)31-18-8(23)3-10-12(15(18)26)13(24)5-1-6(21)7(22)2-9(5)29-10/h1-3,11,14,16-17,19-23,25-28H,4H2/t11-,14-,16+,17-,19+/m1/s1 | PDB MMDB
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| n/a | n/a | 6.78E+4 | n/a | n/a | n/a | n/a | 7.5 | 25 |
University of Delaware
| Assay Description Ubiquitin-7-amino-4-methylcoumarin (Ub-AMC) was generated as previously described.(7) The enzymatic reaction was conducted in fluorometric assay buff... |
ACS Chem Biol 12: 2399-2407 (2017)
Article DOI: 10.1021/acschembio.7b00543 BindingDB Entry DOI: 10.7270/Q21J97WD |
More data for this Ligand-Target Pair | |
Ubiquitin carboxyl-terminal hydrolase 2
(Homo sapiens (Human)) | BDBM50423778
(Leukerin | MERCAPTOPURINE | Mercaleukin | Mercapto...)Show InChI InChI=1S/C5H4N4S/c10-5-3-4(7-1-6-3)8-2-9-5/h1-2H,(H2,6,7,8,9,10) | PDB MMDB
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| | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
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Citation and Details
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More data for this Ligand-Target Pair | |
Ubiquitin carboxyl-terminal hydrolase 2
(Homo sapiens (Human)) | BDBM50007788
(CHEMBL3233809 | med.21724, Compound 167)Show SMILES C[C@@H](N1CCC(CC1)C(=O)NCc1cccc(NC(C)=O)c1)c1cccc2ccccc12 |r| Show InChI InChI=1S/C27H31N3O2/c1-19(25-12-6-9-22-8-3-4-11-26(22)25)30-15-13-23(14-16-30)27(32)28-18-21-7-5-10-24(17-21)29-20(2)31/h3-12,17,19,23H,13-16,18H2,1-2H3,(H,28,32)(H,29,31)/t19-/m1/s1 | PDB MMDB
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| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Purdue University
Curated by ChEMBL
| Assay Description Inhibition of human USP2 using Ub-rhodamine 110 as substrate |
J Med Chem 57: 2393-412 (2014)
Article DOI: 10.1021/jm401712t BindingDB Entry DOI: 10.7270/Q2KK9DBM |
More data for this Ligand-Target Pair | |
Ubiquitin carboxyl-terminal hydrolase 2
(Homo sapiens (Human)) | BDBM50458417
(CHEMBL4203489)Show SMILES CCCn1nc(C(=O)OCc2cc(on2)-c2cccs2)c2ccccc2c1=O Show InChI InChI=1S/C20H17N3O4S/c1-2-9-23-19(24)15-7-4-3-6-14(15)18(21-23)20(25)26-12-13-11-16(27-22-13)17-8-5-10-28-17/h3-8,10-11H,2,9,12H2,1H3 | PDB MMDB
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| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Jagiellonian University
Curated by ChEMBL
| Assay Description Inhibition of human USP2a (258 to 605 residues) expressed in Escherichia coli BL21(DE3) using Ub-AMC as substrate incubated for 30 mins measured at 3... |
Eur J Med Chem 150: 261-267 (2018)
Article DOI: 10.1016/j.ejmech.2018.03.009 BindingDB Entry DOI: 10.7270/Q28G8P98 |
More data for this Ligand-Target Pair | |
Ubiquitin carboxyl-terminal hydrolase 2
(Homo sapiens (Human)) | BDBM65524
((-)-Aricine | Heterophylline (VAN) | Quinovatine)Show SMILES COC(=O)C1=CO[C@@H](C)[C@@H]2CN3CCc4c([nH]c5cc(OC)ccc45)[C@@H]3C[C@H]12 |t:4| Show InChI InChI=1S/C22H26N2O4/c1-12-17-10-24-7-6-15-14-5-4-13(26-2)8-19(14)23-21(15)20(24)9-16(17)18(11-28-12)22(25)27-3/h4-5,8,11-12,16-17,20,23H,6-7,9-10H2,1-3H3/t12-,16-,17-,20-/m0/s1 | PDB MMDB
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| n/a | n/a | >1.14E+5 | n/a | n/a | n/a | n/a | 7.5 | 25 |
University of Delaware
| Assay Description Ubiquitin-7-amino-4-methylcoumarin (Ub-AMC) was generated as previously described.(7) The enzymatic reaction was conducted in fluorometric assay buff... |
ACS Chem Biol 12: 2399-2407 (2017)
Article DOI: 10.1021/acschembio.7b00543 BindingDB Entry DOI: 10.7270/Q21J97WD |
More data for this Ligand-Target Pair | |
Ubiquitin carboxyl-terminal hydrolase 2
(Homo sapiens (Human)) | BDBM50069762
(CHEMBL3182437 | ML323 | US9802904, 87)Show SMILES CC(C)c1ccccc1-c1ncc(C)c(NCc2ccc(cc2)-n2ccnn2)n1 Show InChI InChI=1S/C23H24N6/c1-16(2)20-6-4-5-7-21(20)23-24-14-17(3)22(27-23)25-15-18-8-10-19(11-9-18)29-13-12-26-28-29/h4-14,16H,15H2,1-3H3,(H,24,25,27) | PDB MMDB
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| n/a | n/a | >1.14E+5 | n/a | n/a | n/a | n/a | 7.5 | 25 |
University of Delaware
| Assay Description Ubiquitin-7-amino-4-methylcoumarin (Ub-AMC) was generated as previously described.(7) The enzymatic reaction was conducted in fluorometric assay buff... |
ACS Chem Biol 12: 2399-2407 (2017)
Article DOI: 10.1021/acschembio.7b00543 BindingDB Entry DOI: 10.7270/Q21J97WD |
More data for this Ligand-Target Pair | |
Ubiquitin carboxyl-terminal hydrolase 2
(Homo sapiens (Human)) | BDBM50608424
(CHEMBL5267683) | PDB MMDB
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| | n/a | n/a | >2.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
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Citation and Details
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More data for this Ligand-Target Pair | |
Ubiquitin carboxyl-terminal hydrolase 2
(Homo sapiens (Human)) | BDBM50458416
(CHEMBL1230155)Show InChI InChI=1S/C8H7NO2S/c10-5-6-4-7(11-9-6)8-2-1-3-12-8/h1-4,10H,5H2 | PDB MMDB
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| n/a | n/a | 1.30E+6 | n/a | n/a | n/a | n/a | n/a | n/a |
Jagiellonian University
Curated by ChEMBL
| Assay Description Inhibition of human USP2a (258 to 605 residues) expressed in Escherichia coli BL21(DE3) using Ub-AMC as substrate incubated for 30 mins measured at 3... |
Eur J Med Chem 150: 261-267 (2018)
Article DOI: 10.1016/j.ejmech.2018.03.009 BindingDB Entry DOI: 10.7270/Q28G8P98 |
More data for this Ligand-Target Pair | |
Ubiquitin carboxyl-terminal hydrolase 2
(Homo sapiens (Human)) | BDBM50458421
(CHEMBL1650269)Show InChI InChI=1S/C9H9N3/c10-9-6-8(11-12-9)7-4-2-1-3-5-7/h1-6H,(H3,10,11,12) | PDB MMDB
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| n/a | n/a | >5.00E+6 | n/a | n/a | n/a | n/a | n/a | n/a |
Jagiellonian University
Curated by ChEMBL
| Assay Description Inhibition of human USP2a (258 to 605 residues) expressed in Escherichia coli BL21(DE3) using Ub-AMC as substrate incubated for 30 mins measured at 3... |
Eur J Med Chem 150: 261-267 (2018)
Article DOI: 10.1016/j.ejmech.2018.03.009 BindingDB Entry DOI: 10.7270/Q28G8P98 |
More data for this Ligand-Target Pair | |
Ubiquitin carboxyl-terminal hydrolase 2
(Homo sapiens (Human)) | BDBM50458420
(CHEMBL4207620)Show InChI InChI=1S/C9H9NO/c1-6-3-8(5-10)4-7(2)9(6)11/h3-4,11H,1-2H3 | PDB MMDB
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Jagiellonian University
Curated by ChEMBL
| Assay Description Inhibition of human USP2a (258 to 605 residues) expressed in Escherichia coli BL21(DE3) using Ub-AMC as substrate incubated for 30 mins measured at 3... |
Eur J Med Chem 150: 261-267 (2018)
Article DOI: 10.1016/j.ejmech.2018.03.009 BindingDB Entry DOI: 10.7270/Q28G8P98 |
More data for this Ligand-Target Pair | |
Ubiquitin carboxyl-terminal hydrolase 2
(Homo sapiens (Human)) | BDBM50458418
(CHEMBL4207578)Show InChI InChI=1S/C9H9N3S/c10-5-7-1-3-8(4-2-7)9-6-13-12-11-9/h1-4,6H,5,10H2 | PDB MMDB
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| n/a | n/a | >5.00E+6 | n/a | n/a | n/a | n/a | n/a | n/a |
Jagiellonian University
Curated by ChEMBL
| Assay Description Inhibition of human USP2a (258 to 605 residues) expressed in Escherichia coli BL21(DE3) using Ub-AMC as substrate incubated for 30 mins measured at 3... |
Eur J Med Chem 150: 261-267 (2018)
Article DOI: 10.1016/j.ejmech.2018.03.009 BindingDB Entry DOI: 10.7270/Q28G8P98 |
More data for this Ligand-Target Pair | |