Found 5 hits of kd data for polymerid = 50004763,6342 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50241484
(CHEMBL4095861)Show SMILES CC1CCN(CC1)c1nc(ccc1CNC(=O)Nc1cccc2NC(=O)COc12)C(F)(F)F Show InChI InChI=1S/C22H24F3N5O3/c1-13-7-9-30(10-8-13)20-14(5-6-17(29-20)22(23,24)25)11-26-21(32)28-16-4-2-3-15-19(16)33-12-18(31)27-15/h2-6,13H,7-12H2,1H3,(H,27,31)(H2,26,28,32) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | 0.589 | n/a | n/a | n/a | n/a | n/a |
National Cancer Institute
Curated by ChEMBL
| Assay Description Binding affinity to human TRPV1 expressed in CHO cells after 45 mins by scintillation counting method |
J Med Chem 60: 8246-8252 (2017)
Article DOI: 10.1021/acs.jmedchem.7b00859 BindingDB Entry DOI: 10.7270/Q2QV3PNP |
More data for this Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50241484
(CHEMBL4095861)Show SMILES CC1CCN(CC1)c1nc(ccc1CNC(=O)Nc1cccc2NC(=O)COc12)C(F)(F)F Show InChI InChI=1S/C22H24F3N5O3/c1-13-7-9-30(10-8-13)20-14(5-6-17(29-20)22(23,24)25)11-26-21(32)28-16-4-2-3-15-19(16)33-12-18(31)27-15/h2-6,13H,7-12H2,1H3,(H,27,31)(H2,26,28,32) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | 0.590 | n/a | n/a | n/a | n/a | n/a |
National Cancer Institute
Curated by ChEMBL
| Assay Description Binding affinity to human TRPV1 expressed in CHO cells after 45 mins by scintillation counting method |
J Med Chem 60: 8246-8252 (2017)
Article DOI: 10.1021/acs.jmedchem.7b00859 BindingDB Entry DOI: 10.7270/Q2QV3PNP |
More data for this Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50241485
(CHEMBL4060041)Show SMILES [H][C@]12O[C@@]3(Cc4ccccc4)O[C@]1(C[C@@H](C)[C@]1(O3)[C@]3([H])C=C(C)C(=O)[C@@]3(O)CC(COC(=O)Cc3ccc(O)c(OC)c3)=C[C@]21[H])C(C)=C |r,c:47,t:23,TLB:43:44:12.11:2,46:12:2:16.44.17,11:3:44:12.13.14,18:16:12.11:2,4:3:44:12.13.14,THB:13:12:2:16.44.17,14:16:12.11:2| Show InChI InChI=1S/C37H40O9/c1-21(2)35-17-23(4)37-27(33(35)44-36(45-35,46-37)19-24-9-7-6-8-10-24)14-26(18-34(41)30(37)13-22(3)32(34)40)20-43-31(39)16-25-11-12-28(38)29(15-25)42-5/h6-15,23,27,30,33,38,41H,1,16-20H2,2-5H3/t23-,27-,30-,33-,34-,35-,36+,37-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL MMDB PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | 1.20 | n/a | n/a | n/a | n/a | n/a |
National Cancer Institute
Curated by ChEMBL
| Assay Description Binding affinity to human TRPV1 expressed in CHO cells after 45 mins by scintillation counting method |
J Med Chem 60: 8246-8252 (2017)
Article DOI: 10.1021/acs.jmedchem.7b00859 BindingDB Entry DOI: 10.7270/Q2QV3PNP |
More data for this Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM20458
(1-[(1R)-5-tert-butyl-2,3-dihydro-1H-inden-1-yl]-3-...)Show SMILES CC(C)(C)c1ccc2[C@@H](CCc2c1)NC(=O)Nc1cccc2cnccc12 |r| Show InChI InChI=1S/C23H25N3O/c1-23(2,3)17-8-9-18-15(13-17)7-10-21(18)26-22(27)25-20-6-4-5-16-14-24-12-11-19(16)20/h4-6,8-9,11-14,21H,7,10H2,1-3H3,(H2,25,26,27)/t21-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | 3.40 | n/a | n/a | n/a | n/a | n/a |
National Cancer Institute
Curated by ChEMBL
| Assay Description Displacement of [3H]A-778317 from human TRPV1 expressed in CHO cell membranes after 60 mins by scintillation counting method |
J Med Chem 60: 8246-8252 (2017)
Article DOI: 10.1021/acs.jmedchem.7b00859 BindingDB Entry DOI: 10.7270/Q2QV3PNP |
More data for this Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50329104
(CHEMBL182120 | Indole alkaloid derivative | voacan...)Show SMILES CC[C@H]1C[C@@H]2CN3CCc4c([nH]c5ccc(OC)cc45)[C@](C2)([C@H]13)C(=O)OC |r,THB:2:22:10.9.8.7:21.4.5,1:2:20.21:6.5| Show InChI InChI=1S/C22H28N2O3/c1-4-14-9-13-11-22(21(25)27-3)19-16(7-8-24(12-13)20(14)22)17-10-15(26-2)5-6-18(17)23-19/h5-6,10,13-14,20,23H,4,7-9,11-12H2,1-3H3/t13-,14-,20-,22+/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | 2.00E+4 | n/a | n/a | n/a | n/a | n/a |
University of Shizuoka
Curated by ChEMBL
| Assay Description Competitive antagonist activity at human brain TRPV1 expressed in HEK293T cells assessed as inhibition of CAP-induced intracellular Ca2+ influx prein... |
J Nat Prod 77: 285-97 (2014)
Article DOI: 10.1021/np400885u BindingDB Entry DOI: 10.7270/Q20P11H1 |
More data for this Ligand-Target Pair | |