Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Eukaryotic translation initiation factor 4E (Homo sapiens (Human)) | BDBM50525088 (CHEMBL4461497) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | KEGG PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | 0.0160 | n/a | n/a | n/a | n/a | n/a |
University of Michigan Curated by ChEMBL | Assay Description Binding affinity to N-terminal 10His-tagged m7GDP-bound recombinant human eIF4E expressed in Escherichia coli BL21 (DE3) cells assessed as dissociati... | J Med Chem 62: 4967-4978 (2019) Article DOI: 10.1021/acs.jmedchem.9b00068 BindingDB Entry DOI: 10.7270/Q2JQ14FP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Eukaryotic translation initiation factor 4E (Homo sapiens (Human)) | BDBM50525089 (CHEMBL4464315) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | 0.0460 | n/a | n/a | n/a | n/a | n/a |
University of Michigan Curated by ChEMBL | Assay Description Binding affinity to N-terminal 10His-tagged m7GDP-bound recombinant human eIF4E expressed in Escherichia coli BL21 (DE3) cells assessed as dissociati... | J Med Chem 62: 4967-4978 (2019) Article DOI: 10.1021/acs.jmedchem.9b00068 BindingDB Entry DOI: 10.7270/Q2JQ14FP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Eukaryotic translation initiation factor 4E (Homo sapiens (Human)) | BDBM36609 (Rapamycin C-7, analog 4 | SIROLIMUS | US11603377, ...) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase MCE KEGG PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | 0.5 | n/a | n/a | n/a | n/a | n/a |
University of Toronto Curated by ChEMBL | Assay Description Binding affinity to purified elF4E | Bioorg Med Chem 18: 7746-52 (2010) Article DOI: 10.1016/j.bmc.2010.04.005 BindingDB Entry DOI: 10.7270/Q2KS6RTZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Eukaryotic translation initiation factor 4E (Homo sapiens (Human)) | BDBM50565476 (CHEMBL4780117) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | KEGG PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | 2.20 | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Binding affinity to recombinant human 10His-tagged eIF4E expressed in Escherichia coli BL21 (DE3) cells assessed as binding constant by surface plasm... | Citation and Details Article DOI: 10.1016/j.ejmech.2020.112655 BindingDB Entry DOI: 10.7270/Q2KS6W8F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Eukaryotic translation initiation factor 4E (Homo sapiens (Human)) | BDBM50525091 (CHEMBL4447089) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | 5.20 | n/a | n/a | n/a | n/a | n/a |
University of Michigan Curated by ChEMBL | Assay Description Binding affinity to N-terminal 10His-tagged m7GDP-bound recombinant human eIF4E expressed in Escherichia coli BL21 (DE3) cells assessed as dissociati... | J Med Chem 62: 4967-4978 (2019) Article DOI: 10.1021/acs.jmedchem.9b00068 BindingDB Entry DOI: 10.7270/Q2JQ14FP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Eukaryotic translation initiation factor 4E (Homo sapiens (Human)) | BDBM50525087 (CHEMBL4577429) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | KEGG PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | 5.30 | n/a | n/a | n/a | n/a | n/a |
University of Michigan Curated by ChEMBL | Assay Description Binding affinity to N-terminal 10His-tagged m7GDP-bound recombinant human eIF4E expressed in Escherichia coli BL21 (DE3) cells assessed as dissociati... | J Med Chem 62: 4967-4978 (2019) Article DOI: 10.1021/acs.jmedchem.9b00068 BindingDB Entry DOI: 10.7270/Q2JQ14FP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Eukaryotic translation initiation factor 4E (Homo sapiens (Human)) | BDBM50565475 (CHEMBL4777401) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | KEGG PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | 7.20 | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Binding affinity to recombinant human 10His-tagged eIF4E expressed in Escherichia coli BL21 (DE3) cells assessed as binding constant by surface plasm... | Citation and Details Article DOI: 10.1016/j.ejmech.2020.112655 BindingDB Entry DOI: 10.7270/Q2KS6W8F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Eukaryotic translation initiation factor 4E (Homo sapiens (Human)) | BDBM50525088 (CHEMBL4461497) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | KEGG PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | 17 | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Binding affinity to recombinant human 10His-tagged eIF4E expressed in Escherichia coli BL21 (DE3) cells assessed as binding constant by surface plasm... | Citation and Details Article DOI: 10.1016/j.ejmech.2020.112655 BindingDB Entry DOI: 10.7270/Q2KS6W8F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Eukaryotic translation initiation factor 4E (Homo sapiens (Human)) | BDBM451152 (US10676499, Example 41) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a |
NOVARTIS AG US Patent | Assay Description A subset of compounds was further characterized to determine dissociation constants using thermodynamic (Steady State Affinity) binding analysis. | US Patent US10676499 (2020) BindingDB Entry DOI: 10.7270/Q2K64N44 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Eukaryotic translation initiation factor 4E (Homo sapiens (Human)) | BDBM50525088 (CHEMBL4461497) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | KEGG PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | 21 | n/a | n/a | n/a | n/a | n/a |
University of Michigan Curated by ChEMBL | Assay Description Binding affinity to N-terminal 10His-tagged m7GDP-bound recombinant human eIF4E expressed in Escherichia coli BL21 (DE3) cells assessed as dissociati... | J Med Chem 62: 4967-4978 (2019) Article DOI: 10.1021/acs.jmedchem.9b00068 BindingDB Entry DOI: 10.7270/Q2JQ14FP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Eukaryotic translation initiation factor 4E (Homo sapiens (Human)) | BDBM451149 (US10676499, Example 32) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a |
NOVARTIS AG US Patent | Assay Description A subset of compounds was further characterized to determine dissociation constants using thermodynamic (Steady State Affinity) binding analysis. | US Patent US10676499 (2020) BindingDB Entry DOI: 10.7270/Q2K64N44 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Eukaryotic translation initiation factor 4E (Homo sapiens (Human)) | BDBM50525090 (CHEMBL4558213) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a |
University of Michigan Curated by ChEMBL | Assay Description Binding affinity to N-terminal 10His-tagged m7GDP-bound recombinant human eIF4E expressed in Escherichia coli BL21 (DE3) cells assessed as dissociati... | J Med Chem 62: 4967-4978 (2019) Article DOI: 10.1021/acs.jmedchem.9b00068 BindingDB Entry DOI: 10.7270/Q2JQ14FP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Eukaryotic translation initiation factor 4E (Homo sapiens (Human)) | BDBM50525089 (CHEMBL4464315) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | 48 | n/a | n/a | n/a | n/a | n/a |
University of Michigan Curated by ChEMBL | Assay Description Binding affinity to N-terminal 10His-tagged m7GDP-bound recombinant human eIF4E expressed in Escherichia coli BL21 (DE3) cells assessed as dissociati... | J Med Chem 62: 4967-4978 (2019) Article DOI: 10.1021/acs.jmedchem.9b00068 BindingDB Entry DOI: 10.7270/Q2JQ14FP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Eukaryotic translation initiation factor 4E (Homo sapiens (Human)) | BDBM451158 (US10676499, Example 55) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | 110 | n/a | n/a | n/a | n/a | n/a |
NOVARTIS AG US Patent | Assay Description A subset of compounds was further characterized to determine dissociation constants using thermodynamic (Steady State Affinity) binding analysis. | US Patent US10676499 (2020) BindingDB Entry DOI: 10.7270/Q2K64N44 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Eukaryotic translation initiation factor 4E (Homo sapiens (Human)) | BDBM50525092 (CHEMBL4444144) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | 123 | n/a | n/a | n/a | n/a | n/a |
University of Michigan Curated by ChEMBL | Assay Description Binding affinity to N-terminal 10His-tagged m7GDP-bound recombinant human eIF4E expressed in Escherichia coli BL21 (DE3) cells assessed as dissociati... | J Med Chem 62: 4967-4978 (2019) Article DOI: 10.1021/acs.jmedchem.9b00068 BindingDB Entry DOI: 10.7270/Q2JQ14FP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Eukaryotic translation initiation factor 4E (Homo sapiens (Human)) | BDBM451146 (US10676499, Example 18) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | 160 | n/a | n/a | n/a | n/a | n/a |
NOVARTIS AG US Patent | Assay Description A subset of compounds was further characterized to determine dissociation constants using thermodynamic (Steady State Affinity) binding analysis. | US Patent US10676499 (2020) BindingDB Entry DOI: 10.7270/Q2K64N44 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Eukaryotic translation initiation factor 4E (Homo sapiens (Human)) | BDBM451150 (US10676499, Example 33) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | 220 | n/a | n/a | n/a | n/a | n/a |
NOVARTIS AG US Patent | Assay Description A subset of compounds was further characterized to determine dissociation constants using thermodynamic (Steady State Affinity) binding analysis. | US Patent US10676499 (2020) BindingDB Entry DOI: 10.7270/Q2K64N44 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Eukaryotic translation initiation factor 4E (Homo sapiens (Human)) | BDBM451144 (US10676499, Example 1) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | 300 | n/a | n/a | n/a | n/a | n/a |
NOVARTIS AG US Patent | Assay Description A subset of compounds was further characterized to determine dissociation constants using thermodynamic (Steady State Affinity) binding analysis. | US Patent US10676499 (2020) BindingDB Entry DOI: 10.7270/Q2K64N44 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Eukaryotic translation initiation factor 4E (Homo sapiens (Human)) | BDBM50613700 (CHEBI:50226 | CHEMBL1234303) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | UniChem | n/a | n/a | n/a | 370 | n/a | n/a | n/a | n/a | n/a | |
TBA | Citation and Details | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Eukaryotic translation initiation factor 4E (Homo sapiens (Human)) | BDBM451160 (US10676499, Example 58) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | 410 | n/a | n/a | n/a | n/a | n/a |
NOVARTIS AG US Patent | Assay Description A subset of compounds was further characterized to determine dissociation constants using thermodynamic (Steady State Affinity) binding analysis. | US Patent US10676499 (2020) BindingDB Entry DOI: 10.7270/Q2K64N44 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Eukaryotic translation initiation factor 4E (Homo sapiens (Human)) | BDBM451154 (US10676499, Example 43) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | 580 | n/a | n/a | n/a | n/a | n/a |
NOVARTIS AG US Patent | Assay Description A subset of compounds was further characterized to determine dissociation constants using thermodynamic (Steady State Affinity) binding analysis. | US Patent US10676499 (2020) BindingDB Entry DOI: 10.7270/Q2K64N44 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Eukaryotic translation initiation factor 4E (Homo sapiens (Human)) | BDBM50249977 (CHEMBL1234304) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | n/a | 800 | n/a | n/a | n/a | n/a | n/a |
Department of Internal Medicine, Division of Hematology, Mayo Clinic , Rochester, Minnesota 55905, United States. Curated by ChEMBL | Assay Description Binding affinity to eIF4E (unknown origin) by fluorescence titration assay | J Med Chem 60: 8131-8144 (2017) Article DOI: 10.1021/acs.jmedchem.7b00916 BindingDB Entry DOI: 10.7270/Q28W3GRV | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Eukaryotic translation initiation factor 4E (Homo sapiens (Human)) | BDBM50613701 (CHEBI:17825 | CHEMBL1232939) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PDB UniChem | n/a | n/a | n/a | 3.90E+3 | n/a | n/a | n/a | n/a | n/a | |
TBA | Citation and Details | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Eukaryotic translation initiation factor 4E (Homo sapiens (Human)) | BDBM451156 (US10676499, Example 53) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | 6.00E+3 | n/a | n/a | n/a | n/a | n/a |
NOVARTIS AG US Patent | Assay Description A subset of compounds was further characterized to determine dissociation constants using thermodynamic (Steady State Affinity) binding analysis. | US Patent US10676499 (2020) BindingDB Entry DOI: 10.7270/Q2K64N44 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Eukaryotic translation initiation factor 4E (Homo sapiens (Human)) | BDBM451157 (US10676499, Example 54) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | 6.00E+3 | n/a | n/a | n/a | n/a | n/a |
NOVARTIS AG US Patent | Assay Description A subset of compounds was further characterized to determine dissociation constants using thermodynamic (Steady State Affinity) binding analysis. | US Patent US10676499 (2020) BindingDB Entry DOI: 10.7270/Q2K64N44 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Eukaryotic translation initiation factor 4E (Homo sapiens (Human)) | BDBM451151 (US10676499, Example 40) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | 6.50E+3 | n/a | n/a | n/a | n/a | n/a |
NOVARTIS AG US Patent | Assay Description A subset of compounds was further characterized to determine dissociation constants using thermodynamic (Steady State Affinity) binding analysis. | US Patent US10676499 (2020) BindingDB Entry DOI: 10.7270/Q2K64N44 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Eukaryotic translation initiation factor 4E (Homo sapiens (Human)) | BDBM451159 (US10676499, Example 57) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | 6.50E+3 | n/a | n/a | n/a | n/a | n/a |
NOVARTIS AG US Patent | Assay Description A subset of compounds was further characterized to determine dissociation constants using thermodynamic (Steady State Affinity) binding analysis. | US Patent US10676499 (2020) BindingDB Entry DOI: 10.7270/Q2K64N44 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Eukaryotic translation initiation factor 4E (Homo sapiens (Human)) | BDBM451148 (US10676499, Example 29) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | 6.50E+3 | n/a | n/a | n/a | n/a | n/a |
NOVARTIS AG US Patent | Assay Description A subset of compounds was further characterized to determine dissociation constants using thermodynamic (Steady State Affinity) binding analysis. | US Patent US10676499 (2020) BindingDB Entry DOI: 10.7270/Q2K64N44 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Eukaryotic translation initiation factor 4E (Homo sapiens (Human)) | BDBM451147 (US10676499, Example 26) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | 6.50E+3 | n/a | n/a | n/a | n/a | n/a |
NOVARTIS AG US Patent | Assay Description A subset of compounds was further characterized to determine dissociation constants using thermodynamic (Steady State Affinity) binding analysis. | US Patent US10676499 (2020) BindingDB Entry DOI: 10.7270/Q2K64N44 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Eukaryotic translation initiation factor 4E (Homo sapiens (Human)) | BDBM451153 (US10676499, Example 42) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | 6.50E+3 | n/a | n/a | n/a | n/a | n/a |
NOVARTIS AG US Patent | Assay Description A subset of compounds was further characterized to determine dissociation constants using thermodynamic (Steady State Affinity) binding analysis. | US Patent US10676499 (2020) BindingDB Entry DOI: 10.7270/Q2K64N44 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Eukaryotic translation initiation factor 4E (Homo sapiens (Human)) | BDBM451155 (US10676499, Example 49) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | 6.50E+3 | n/a | n/a | n/a | n/a | n/a |
NOVARTIS AG US Patent | Assay Description A subset of compounds was further characterized to determine dissociation constants using thermodynamic (Steady State Affinity) binding analysis. | US Patent US10676499 (2020) BindingDB Entry DOI: 10.7270/Q2K64N44 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Eukaryotic translation initiation factor 4E (Homo sapiens (Human)) | BDBM50607960 (CHEMBL5289039) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | UniChem | n/a | n/a | n/a | 2.50E+4 | n/a | n/a | n/a | n/a | n/a | |
TBA | Citation and Details | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Eukaryotic translation initiation factor 4E (Homo sapiens (Human)) | BDBM50613702 (CHEMBL5282449) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PDB UniChem | PDB | n/a | n/a | n/a | 5.65E+4 | n/a | n/a | n/a | n/a | n/a |
TBA | Citation and Details | ||||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Eukaryotic translation initiation factor 4E (Homo sapiens (Human)) | BDBM50613704 (CHEMBL5283082) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | UniChem | n/a | n/a | n/a | 5.78E+4 | n/a | n/a | n/a | n/a | n/a | |
TBA | Citation and Details | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Eukaryotic translation initiation factor 4E (Homo sapiens (Human)) | BDBM50613703 (CHEMBL5286550) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | UniChem | n/a | n/a | n/a | 1.33E+5 | n/a | n/a | n/a | n/a | n/a | |
TBA | Citation and Details | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Eukaryotic translation initiation factor 4E (Homo sapiens (Human)) | BDBM50044268 (CHEMBL3310215) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | 5.01E+6 | n/a | n/a | n/a | n/a | n/a |
Harvard Medical School Curated by ChEMBL | Assay Description Binding affinity to human full length recombinant GST-tagged eIF4E expressed in Escherichia coli BL21(DE3) by intrinsic tryptophan fluorescence quenc... | Eur J Med Chem 77: 361-77 (2014) Article DOI: 10.1016/j.ejmech.2014.03.034 BindingDB Entry DOI: 10.7270/Q2Z89F19 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Eukaryotic translation initiation factor 4E (Homo sapiens (Human)) | BDBM50018919 (CHEMBL254578) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | 8.74E+6 | n/a | n/a | n/a | n/a | n/a |
Harvard Medical School Curated by ChEMBL | Assay Description Binding affinity to human full length recombinant GST-tagged eIF4E expressed in Escherichia coli BL21(DE3) by intrinsic tryptophan fluorescence quenc... | Eur J Med Chem 77: 361-77 (2014) Article DOI: 10.1016/j.ejmech.2014.03.034 BindingDB Entry DOI: 10.7270/Q2Z89F19 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Eukaryotic translation initiation factor 4E (Homo sapiens (Human)) | BDBM50044269 (CHEMBL3310347) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | 3.66E+7 | n/a | n/a | n/a | n/a | n/a |
Harvard Medical School Curated by ChEMBL | Assay Description Binding affinity to human full length recombinant GST-tagged eIF4E expressed in Escherichia coli BL21(DE3) by intrinsic tryptophan fluorescence quenc... | Eur J Med Chem 77: 361-77 (2014) Article DOI: 10.1016/j.ejmech.2014.03.034 BindingDB Entry DOI: 10.7270/Q2Z89F19 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Eukaryotic translation initiation factor 4E (Homo sapiens (Human)) | BDBM451155 (US10676499, Example 49) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
NOVARTIS AG US Patent | Assay Description Dual histidine and Avi tagged human EIF4E (His6-3C-avi-eIF4E) was expressed in 8 L of TB Media. Induction by 0.4 mM IPTG occurred at 2.0 OD600, and c... | US Patent US10676499 (2020) BindingDB Entry DOI: 10.7270/Q2K64N44 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Eukaryotic translation initiation factor 4E (Homo sapiens (Human)) | BDBM50316302 (((2R,3S,4R,5R)-5-(2-amino-7-methyl-6-oxo-1H-purin-...) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL KEGG PC cid PC sid PDB UniChem Similars | PDB Article PubMed | 28 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc. Curated by ChEMBL | Assay Description Competitive inhibition of [3H]m7-GTP binding to human FLAG-His6 tagged eIF4E expressed in Escherichia coli by scintillation proximity assay | J Med Chem 55: 3837-51 (2012) Article DOI: 10.1021/jm300037x BindingDB Entry DOI: 10.7270/Q27082GX | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Eukaryotic translation initiation factor 4E (Homo sapiens (Human)) | BDBM451159 (US10676499, Example 57) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
NOVARTIS AG US Patent | Assay Description Dual histidine and Avi tagged human EIF4E (His6-3C-avi-eIF4E) was expressed in 8 L of TB Media. Induction by 0.4 mM IPTG occurred at 2.0 OD600, and c... | US Patent US10676499 (2020) BindingDB Entry DOI: 10.7270/Q2K64N44 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Eukaryotic translation initiation factor 4E (Homo sapiens (Human)) | BDBM451145 (US10676499, Example 17) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
NOVARTIS AG US Patent | Assay Description Dual histidine and Avi tagged human EIF4E (His6-3C-avi-eIF4E) was expressed in 8 L of TB Media. Induction by 0.4 mM IPTG occurred at 2.0 OD600, and c... | US Patent US10676499 (2020) BindingDB Entry DOI: 10.7270/Q2K64N44 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Eukaryotic translation initiation factor 4E (Homo sapiens (Human)) | BDBM451148 (US10676499, Example 29) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
NOVARTIS AG US Patent | Assay Description Dual histidine and Avi tagged human EIF4E (His6-3C-avi-eIF4E) was expressed in 8 L of TB Media. Induction by 0.4 mM IPTG occurred at 2.0 OD600, and c... | US Patent US10676499 (2020) BindingDB Entry DOI: 10.7270/Q2K64N44 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Eukaryotic translation initiation factor 4E (Homo sapiens (Human)) | BDBM451158 (US10676499, Example 55) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
NOVARTIS AG US Patent | Assay Description Dual histidine and Avi tagged human EIF4E (His6-3C-avi-eIF4E) was expressed in 8 L of TB Media. Induction by 0.4 mM IPTG occurred at 2.0 OD600, and c... | US Patent US10676499 (2020) BindingDB Entry DOI: 10.7270/Q2K64N44 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Eukaryotic translation initiation factor 4E (Homo sapiens (Human)) | BDBM451147 (US10676499, Example 26) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 50 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
NOVARTIS AG US Patent | Assay Description Dual histidine and Avi tagged human EIF4E (His6-3C-avi-eIF4E) was expressed in 8 L of TB Media. Induction by 0.4 mM IPTG occurred at 2.0 OD600, and c... | US Patent US10676499 (2020) BindingDB Entry DOI: 10.7270/Q2K64N44 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Eukaryotic translation initiation factor 4E (Homo sapiens (Human)) | BDBM451144 (US10676499, Example 1) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 100 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
NOVARTIS AG US Patent | Assay Description Dual histidine and Avi tagged human EIF4E (His6-3C-avi-eIF4E) was expressed in 8 L of TB Media. Induction by 0.4 mM IPTG occurred at 2.0 OD600, and c... | US Patent US10676499 (2020) BindingDB Entry DOI: 10.7270/Q2K64N44 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Eukaryotic translation initiation factor 4E (Homo sapiens (Human)) | BDBM451150 (US10676499, Example 33) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 170 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
NOVARTIS AG US Patent | Assay Description Dual histidine and Avi tagged human EIF4E (His6-3C-avi-eIF4E) was expressed in 8 L of TB Media. Induction by 0.4 mM IPTG occurred at 2.0 OD600, and c... | US Patent US10676499 (2020) BindingDB Entry DOI: 10.7270/Q2K64N44 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Eukaryotic translation initiation factor 4E (Homo sapiens (Human)) | BDBM451146 (US10676499, Example 18) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 180 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
NOVARTIS AG US Patent | Assay Description Dual histidine and Avi tagged human EIF4E (His6-3C-avi-eIF4E) was expressed in 8 L of TB Media. Induction by 0.4 mM IPTG occurred at 2.0 OD600, and c... | US Patent US10676499 (2020) BindingDB Entry DOI: 10.7270/Q2K64N44 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Eukaryotic translation initiation factor 4E (Homo sapiens (Human)) | BDBM451156 (US10676499, Example 53) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 190 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
NOVARTIS AG US Patent | Assay Description Dual histidine and Avi tagged human EIF4E (His6-3C-avi-eIF4E) was expressed in 8 L of TB Media. Induction by 0.4 mM IPTG occurred at 2.0 OD600, and c... | US Patent US10676499 (2020) BindingDB Entry DOI: 10.7270/Q2K64N44 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Eukaryotic translation initiation factor 4E (Homo sapiens (Human)) | BDBM451160 (US10676499, Example 58) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
NOVARTIS AG US Patent | Assay Description Dual histidine and Avi tagged human EIF4E (His6-3C-avi-eIF4E) was expressed in 8 L of TB Media. Induction by 0.4 mM IPTG occurred at 2.0 OD600, and c... | US Patent US10676499 (2020) BindingDB Entry DOI: 10.7270/Q2K64N44 | |||||||||||
More data for this Ligand-Target Pair |
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