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Patent code US10709709

Compile Data Set for Download or QSAR

Found 212 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))		BDBM451266
PNG
(US10709709, Example 93)
Show SMILES Cc1ncnc2n(ccc12)[C@@H]1C[C@H](Oc2cc(Cl)c(F)c3CCNCc23)[C@@H](O)[C@H]1O |r|
Show InChI InChI=1S/C21H22ClFN4O3/c1-10-11-3-5-27(21(11)26-9-25-10)15-7-17(20(29)19(15)28)30-16-6-14(22)18(23)12-2-4-24-8-13(12)16/h3,5-6,9,15,17,19-20,24,28-29H,2,4,7-8H2,1H3/t15-,17+,19+,20-/m1/s1
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Pfizer Inc.

US Patent


Assay Description
Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...

US Patent US10709709 (2020)


BindingDB Entry DOI: 10.7270/Q26113CC
More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))		BDBM451278
PNG
(US10709709, Example 105)
Show SMILES Cc1cc2CCNCc2c(O[C@H]2C[C@H]([C@H](O)[C@@H]2O)n2cc(F)c3c(N)ncnc23)c1 |r|
Show InChI InChI=1S/C21H24FN5O3/c1-10-4-11-2-3-24-7-12(11)15(5-10)30-16-6-14(18(28)19(16)29)27-8-13(22)17-20(23)25-9-26-21(17)27/h4-5,8-9,14,16,18-19,24,28-29H,2-3,6-7H2,1H3,(H2,23,25,26)/t14-,16+,18+,19-/m1/s1
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Pfizer Inc.

US Patent


Assay Description
Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...

US Patent US10709709 (2020)


BindingDB Entry DOI: 10.7270/Q26113CC
More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))		BDBM451293
PNG
(US10709709, Example 120)
Show SMILES Nc1ncnc2n(cc(Br)c12)[C@@H]1C[C@H](Oc2cc(cc3CCNCc23)C#N)[C@@H](O)[C@H]1O |r|
Show InChI InChI=1S/C21H21BrN6O3/c22-13-8-28(21-17(13)20(24)26-9-27-21)14-5-16(19(30)18(14)29)31-15-4-10(6-23)3-11-1-2-25-7-12(11)15/h3-4,8-9,14,16,18-19,25,29-30H,1-2,5,7H2,(H2,24,26,27)/t14-,16+,18+,19-/m1/s1
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Pfizer Inc.

US Patent


Assay Description
Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...

US Patent US10709709 (2020)


BindingDB Entry DOI: 10.7270/Q26113CC
More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))		BDBM451299
PNG
(US10709709, Example 126)
Show SMILES Cc1nc(N)c2c(F)cn([C@@H]3C[C@H](Oc4ccc(F)c5CCNCc45)[C@@H](O)[C@H]3O)c2n1 |r|
Show InChI InChI=1S/C21H23F2N5O3/c1-9-26-20(24)17-13(23)8-28(21(17)27-9)14-6-16(19(30)18(14)29)31-15-3-2-12(22)10-4-5-25-7-11(10)15/h2-3,8,14,16,18-19,25,29-30H,4-7H2,1H3,(H2,24,26,27)/t14-,16+,18+,19-/m1/s1
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Pfizer Inc.

US Patent


Assay Description
Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...

US Patent US10709709 (2020)


BindingDB Entry DOI: 10.7270/Q26113CC
More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))		BDBM451302
PNG
(US10709709, Example 129)
Show SMILES Cc1cc2CCNCc2c(O[C@H]2C[C@H]([C@H](O)[C@@H]2O)n2cc(Cl)c3c(N)ncnc23)c1 |r|
Show InChI InChI=1S/C21H24ClN5O3/c1-10-4-11-2-3-24-7-12(11)15(5-10)30-16-6-14(18(28)19(16)29)27-8-13(22)17-20(23)25-9-26-21(17)27/h4-5,8-9,14,16,18-19,24,28-29H,2-3,6-7H2,1H3,(H2,23,25,26)/t14-,16+,18+,19-/m1/s1
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Pfizer Inc.

US Patent


Assay Description
Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...

US Patent US10709709 (2020)


BindingDB Entry DOI: 10.7270/Q26113CC
More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))		BDBM451351
PNG
(US10709709, Example 181)
Show SMILES Cc1cc2CCNCc2c(O[C@H]2C[C@H]([C@H](O)[C@@H]2O)n2ccc3c(C)ncnc23)n1 |r|
Show InChI InChI=1S/C21H25N5O3/c1-11-7-13-3-5-22-9-15(13)21(25-11)29-17-8-16(18(27)19(17)28)26-6-4-14-12(2)23-10-24-20(14)26/h4,6-7,10,16-19,22,27-28H,3,5,8-9H2,1-2H3/t16-,17+,18+,19-/m1/s1
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Pfizer Inc.

US Patent


Assay Description
Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...

US Patent US10709709 (2020)


BindingDB Entry DOI: 10.7270/Q26113CC
More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))		BDBM50523654
PNG
(CHEMBL4455651 | US10709709, Example 212)
Show SMILES CC1CNCc2c(O[C@H]3C[C@H]([C@H](O)[C@@H]3O)n3ccc4c(C)ncnc34)cc(C(F)F)c(F)c12 |r|
Show InChI InChI=1S/C23H25F3N4O3/c1-10-7-27-8-14-16(5-13(22(25)26)19(24)18(10)14)33-17-6-15(20(31)21(17)32)30-4-3-12-11(2)28-9-29-23(12)30/h3-5,9-10,15,17,20-22,27,31-32H,6-8H2,1-2H3/t10?,15-,17+,20+,21-/m1/s1
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Pfizer Inc.

US Patent


Assay Description
Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...

US Patent US10709709 (2020)


BindingDB Entry DOI: 10.7270/Q26113CC
More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))		BDBM451280
PNG
(US10709709, Example 107)
Show SMILES Nc1ncnc2n(cc(F)c12)[C@@H]1C[C@H](Oc2cc(F)cc3CCNCc23)[C@@H](O)[C@H]1O |r|
Show InChI InChI=1S/C20H21F2N5O3/c21-10-3-9-1-2-24-6-11(9)14(4-10)30-15-5-13(17(28)18(15)29)27-7-12(22)16-19(23)25-8-26-20(16)27/h3-4,7-8,13,15,17-18,24,28-29H,1-2,5-6H2,(H2,23,25,26)/t13-,15+,17+,18-/m1/s1
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Pfizer Inc.

US Patent


Assay Description
Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...

US Patent US10709709 (2020)


BindingDB Entry DOI: 10.7270/Q26113CC
More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))		BDBM451303
PNG
(US10709709, Example 130)
Show SMILES Nc1ncnc2n(cc(Cl)c12)[C@@H]1C[C@H](Oc2cc(Cl)cc3CCNCc23)[C@@H](O)[C@H]1O |r|
Show InChI InChI=1S/C20H21Cl2N5O3/c21-10-3-9-1-2-24-6-11(9)14(4-10)30-15-5-13(17(28)18(15)29)27-7-12(22)16-19(23)25-8-26-20(16)27/h3-4,7-8,13,15,17-18,24,28-29H,1-2,5-6H2,(H2,23,25,26)/t13-,15+,17+,18-/m1/s1
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Pfizer Inc.

US Patent


Assay Description
Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...

US Patent US10709709 (2020)


BindingDB Entry DOI: 10.7270/Q26113CC
More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))		BDBM451341
PNG
(US10709709, Example 170)
Show SMILES Cc1ncnc2n(ccc12)[C@@H]1C[C@H](Oc2cc(cc3CCNCc23)-c2cnco2)[C@@H](O)[C@H]1O |r|
Show InChI InChI=1S/C24H25N5O4/c1-13-16-3-5-29(24(16)28-11-27-13)18-8-20(23(31)22(18)30)33-19-7-15(21-10-26-12-32-21)6-14-2-4-25-9-17(14)19/h3,5-7,10-12,18,20,22-23,25,30-31H,2,4,8-9H2,1H3/t18-,20+,22+,23-/m1/s1
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Pfizer Inc.

US Patent


Assay Description
Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...

US Patent US10709709 (2020)


BindingDB Entry DOI: 10.7270/Q26113CC
More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))		BDBM451349
PNG
(US10709709, Example 179)
Show SMILES Cc1cn([C@@H]2C[C@H](Oc3cc(F)c(F)c4CCNCc34)[C@@H](O)[C@H]2O)c2nc(C)nc(N)c12 |r|
Show InChI InChI=1S/C22H25F2N5O3/c1-9-8-29(22-17(9)21(25)27-10(2)28-22)14-6-16(20(31)19(14)30)32-15-5-13(23)18(24)11-3-4-26-7-12(11)15/h5,8,14,16,19-20,26,30-31H,3-4,6-7H2,1-2H3,(H2,25,27,28)/t14-,16+,19+,20-/m1/s1
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Pfizer Inc.

US Patent


Assay Description
Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...

US Patent US10709709 (2020)


BindingDB Entry DOI: 10.7270/Q26113CC
More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))		BDBM451373
PNG
(US10709709, Example 203)
Show SMILES Cc1ncnc2n(ccc12)[C@@H]1C[C@H](Oc2cc(F)cc3OCCNCc23)[C@@H](O)[C@H]1O |r|
Show InChI InChI=1S/C21H23FN4O4/c1-11-13-2-4-26(21(13)25-10-24-11)15-8-18(20(28)19(15)27)30-17-7-12(22)6-16-14(17)9-23-3-5-29-16/h2,4,6-7,10,15,18-20,23,27-28H,3,5,8-9H2,1H3/t15-,18+,19+,20-/m1/s1
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Pfizer Inc.

US Patent


Assay Description
Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...

US Patent US10709709 (2020)


BindingDB Entry DOI: 10.7270/Q26113CC
More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))		BDBM451281
PNG
(US10709709, Example 108)
Show SMILES Nc1ncnc2n(cc(F)c12)[C@@H]1C[C@H](Oc2cc(Cl)c(F)c3CCNCc23)[C@@H](O)[C@H]1O |r|
Show InChI InChI=1S/C20H20ClF2N5O3/c21-10-3-13(9-5-25-2-1-8(9)16(10)23)31-14-4-12(17(29)18(14)30)28-6-11(22)15-19(24)26-7-27-20(15)28/h3,6-7,12,14,17-18,25,29-30H,1-2,4-5H2,(H2,24,26,27)/t12-,14+,17+,18-/m1/s1
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Pfizer Inc.

US Patent


Assay Description
Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...

US Patent US10709709 (2020)


BindingDB Entry DOI: 10.7270/Q26113CC
More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))		BDBM451282
PNG
(US10709709, Example 109)
Show SMILES Nc1ncnc2n(cc(F)c12)[C@@H]1C[C@H](Oc2cc(Br)c(F)c3CCNCc23)[C@@H](O)[C@H]1O |r|
Show InChI InChI=1S/C20H20BrF2N5O3/c21-10-3-13(9-5-25-2-1-8(9)16(10)23)31-14-4-12(17(29)18(14)30)28-6-11(22)15-19(24)26-7-27-20(15)28/h3,6-7,12,14,17-18,25,29-30H,1-2,4-5H2,(H2,24,26,27)/t12-,14+,17+,18-/m1/s1
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Pfizer Inc.

US Patent


Assay Description
Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...

US Patent US10709709 (2020)


BindingDB Entry DOI: 10.7270/Q26113CC
More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))		BDBM451312
PNG
(US10709709, Example 139)
Show SMILES C[C@H](N)c1cc(F)c(Cl)cc1O[C@H]1C[C@H]([C@H](O)[C@@H]1O)n1ccc2c(C)ncnc12 |r|
Show InChI InChI=1S/C20H22ClFN4O3/c1-9(23)12-5-14(22)13(21)6-16(12)29-17-7-15(18(27)19(17)28)26-4-3-11-10(2)24-8-25-20(11)26/h3-6,8-9,15,17-19,27-28H,7,23H2,1-2H3/t9-,15+,17-,18-,19+/m0/s1
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Pfizer Inc.

US Patent


Assay Description
Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...

US Patent US10709709 (2020)


BindingDB Entry DOI: 10.7270/Q26113CC
More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))		BDBM50523661
PNG
(CHEMBL4547524 | US10709709, Example 154)
Show SMILES Cc1ncnc2n(ccc12)[C@@H]1C[C@H](Oc2cc(cc3CCNCc23)C(F)F)[C@@H](O)[C@H]1O |r|
Show InChI InChI=1S/C22H24F2N4O3/c1-11-14-3-5-28(22(14)27-10-26-11)16-8-18(20(30)19(16)29)31-17-7-13(21(23)24)6-12-2-4-25-9-15(12)17/h3,5-7,10,16,18-21,25,29-30H,2,4,8-9H2,1H3/t16-,18+,19+,20-/m1/s1
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Pfizer Inc.

US Patent


Assay Description
Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...

US Patent US10709709 (2020)


BindingDB Entry DOI: 10.7270/Q26113CC
More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))		BDBM451365
PNG
(US10709709, Example 195)
Show SMILES Nc1ncnc2n(cc(F)c12)[C@@H]1C[C@H](Oc2cc(cc3CCNCc23)C(F)F)[C@@H](O)[C@H]1O |r|
Show InChI InChI=1S/C21H22F3N5O3/c22-12-7-29(21-16(12)20(25)27-8-28-21)13-5-15(18(31)17(13)30)32-14-4-10(19(23)24)3-9-1-2-26-6-11(9)14/h3-4,7-8,13,15,17-19,26,30-31H,1-2,5-6H2,(H2,25,27,28)/t13-,15+,17+,18-/m1/s1
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Pfizer Inc.

US Patent


Assay Description
Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...

US Patent US10709709 (2020)


BindingDB Entry DOI: 10.7270/Q26113CC
More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))		BDBM451367
PNG
(US10709709, Example 197)
Show SMILES Cc1ncnc2n(ccc12)[C@@H]1C[C@H](Oc2cc(cc3CCNCc23)-c2cnoc2)[C@@H](O)[C@H]1O |r|
Show InChI InChI=1S/C24H25N5O4/c1-13-17-3-5-29(24(17)27-12-26-13)19-8-21(23(31)22(19)30)33-20-7-15(16-9-28-32-11-16)6-14-2-4-25-10-18(14)20/h3,5-7,9,11-12,19,21-23,25,30-31H,2,4,8,10H2,1H3/t19-,21+,22+,23-/m1/s1
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Pfizer Inc.

US Patent


Assay Description
Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...

US Patent US10709709 (2020)


BindingDB Entry DOI: 10.7270/Q26113CC
More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))		BDBM451261
PNG
(US10709709, Example 88)
Show SMILES Cc1cc2CCNCc2c(O[C@H]2C[C@H]([C@H](O)[C@@H]2O)n2ccc3c(C)ncnc23)c1 |r|
Show InChI InChI=1S/C22H26N4O3/c1-12-7-14-3-5-23-10-16(14)18(8-12)29-19-9-17(20(27)21(19)28)26-6-4-15-13(2)24-11-25-22(15)26/h4,6-8,11,17,19-21,23,27-28H,3,5,9-10H2,1-2H3/t17-,19+,20+,21-/m1/s1
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Pfizer Inc.

US Patent


Assay Description
Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...

US Patent US10709709 (2020)


BindingDB Entry DOI: 10.7270/Q26113CC
More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))		BDBM451276
PNG
(US10709709, Example 103)
Show SMILES Nc1ncnc2n(cc(F)c12)[C@@H]1C[C@H](Oc2cc(F)c(F)c3CCNCc23)[C@@H](O)[C@H]1O |r|
Show InChI InChI=1S/C20H20F3N5O3/c21-10-3-13(9-5-25-2-1-8(9)16(10)23)31-14-4-12(17(29)18(14)30)28-6-11(22)15-19(24)26-7-27-20(15)28/h3,6-7,12,14,17-18,25,29-30H,1-2,4-5H2,(H2,24,26,27)/t12-,14+,17+,18-/m1/s1
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Pfizer Inc.

US Patent


Assay Description
Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...

US Patent US10709709 (2020)


BindingDB Entry DOI: 10.7270/Q26113CC
More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))		BDBM451277
PNG
(US10709709, Example 104)
Show SMILES Nc1ncnc2n(cc(F)c12)[C@@H]1C[C@H](Oc2cc(cc3CCNCc23)C(F)(F)F)[C@@H](O)[C@H]1O |r|
Show InChI InChI=1S/C21H21F4N5O3/c22-12-7-30(20-16(12)19(26)28-8-29-20)13-5-15(18(32)17(13)31)33-14-4-10(21(23,24)25)3-9-1-2-27-6-11(9)14/h3-4,7-8,13,15,17-18,27,31-32H,1-2,5-6H2,(H2,26,28,29)/t13-,15+,17+,18-/m1/s1
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Pfizer Inc.

US Patent


Assay Description
Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...

US Patent US10709709 (2020)


BindingDB Entry DOI: 10.7270/Q26113CC
More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))		BDBM451360
PNG
(US10709709, Example 190)
Show SMILES Cc1ncnc2n(ccc12)[C@@H]1C[C@H](Oc2cc(C(F)F)c(F)c3CCNCc23)C(O)=C1O |r,c:33|
Show InChI InChI=1S/C22H21F3N4O3/c1-10-11-3-5-29(22(11)28-9-27-10)15-7-17(20(31)19(15)30)32-16-6-13(21(24)25)18(23)12-2-4-26-8-14(12)16/h3,5-6,9,15,17,21,26,30-31H,2,4,7-8H2,1H3/t15-,17+/m1/s1
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Pfizer Inc.

US Patent


Assay Description
Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...

US Patent US10709709 (2020)


BindingDB Entry DOI: 10.7270/Q26113CC
More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))		BDBM451366
PNG
(US10709709, Example 196)
Show SMILES Nc1ncnc2n(cc(F)c12)[C@@H]1C[C@H](Oc2cc(C(F)F)c(F)c3CCNCc23)[C@@H](O)[C@H]1O |r|
Show InChI InChI=1S/C21H21F4N5O3/c22-11-6-30(21-15(11)20(26)28-7-29-21)12-4-14(18(32)17(12)31)33-13-3-9(19(24)25)16(23)8-1-2-27-5-10(8)13/h3,6-7,12,14,17-19,27,31-32H,1-2,4-5H2,(H2,26,28,29)/t12-,14+,17+,18-/m1/s1
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Pfizer Inc.

US Patent


Assay Description
Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...

US Patent US10709709 (2020)


BindingDB Entry DOI: 10.7270/Q26113CC
More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))		BDBM50523652
PNG
(CHEMBL4445368 | US10709709, Example 89)
Show SMILES Cc1ncnc2n(ccc12)[C@@H]1C[C@H](Oc2cc(Br)cc3CCNCc23)[C@@H](O)[C@H]1O |r|
Show InChI InChI=1S/C21H23BrN4O3/c1-11-14-3-5-26(21(14)25-10-24-11)16-8-18(20(28)19(16)27)29-17-7-13(22)6-12-2-4-23-9-15(12)17/h3,5-7,10,16,18-20,23,27-28H,2,4,8-9H2,1H3/t16-,18+,19+,20-/m1/s1
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Pfizer Inc.

US Patent


Assay Description
Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...

US Patent US10709709 (2020)


BindingDB Entry DOI: 10.7270/Q26113CC
More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))		BDBM50523650
PNG
(CHEMBL4541232 | US10709709, Example 91)
Show SMILES Cc1ncnc2n(ccc12)[C@@H]1C[C@H](Oc2cc(cc3CCNCc23)C#N)[C@@H](O)[C@H]1O |r|
Show InChI InChI=1S/C22H23N5O3/c1-12-15-3-5-27(22(15)26-11-25-12)17-8-19(21(29)20(17)28)30-18-7-13(9-23)6-14-2-4-24-10-16(14)18/h3,5-7,11,17,19-21,24,28-29H,2,4,8,10H2,1H3/t17-,19+,20+,21-/m1/s1
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Pfizer Inc.

US Patent


Assay Description
Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...

US Patent US10709709 (2020)


BindingDB Entry DOI: 10.7270/Q26113CC
More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))		BDBM451292
PNG
(US10709709, Example 119)
Show SMILES Cc1ncnc2n(cc(F)c12)[C@@H]1C[C@H](Oc2cc(cc3CCNCc23)C#N)[C@@H](O)[C@H]1O |r|
Show InChI InChI=1S/C22H22FN5O3/c1-11-19-15(23)9-28(22(19)27-10-26-11)16-6-18(21(30)20(16)29)31-17-5-12(7-24)4-13-2-3-25-8-14(13)17/h4-5,9-10,16,18,20-21,25,29-30H,2-3,6,8H2,1H3/t16-,18+,20+,21-/m1/s1
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Pfizer Inc.

US Patent


Assay Description
Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...

US Patent US10709709 (2020)


BindingDB Entry DOI: 10.7270/Q26113CC
More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))		BDBM451294
PNG
(US10709709, Example 121)
Show SMILES Cc1cn([C@@H]2C[C@H](Oc3ccc(F)c4CCNCc34)[C@@H](O)[C@H]2O)c2ncnc(Cl)c12 |r|
Show InChI InChI=1S/C21H22ClFN4O3/c1-10-8-27(21-17(10)20(22)25-9-26-21)14-6-16(19(29)18(14)28)30-15-3-2-13(23)11-4-5-24-7-12(11)15/h2-3,8-9,14,16,18-19,24,28-29H,4-7H2,1H3/t14-,16+,18+,19-/m1/s1
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Pfizer Inc.

US Patent


Assay Description
Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...

US Patent US10709709 (2020)


BindingDB Entry DOI: 10.7270/Q26113CC
More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))		BDBM451304
PNG
(US10709709, Example 131)
Show SMILES Nc1ncnc2n(cc(Br)c12)[C@@H]1C[C@H](Oc2cc(Cl)cc3CCNCc23)[C@@H](O)[C@H]1O |r|
Show InChI InChI=1S/C20H21BrClN5O3/c21-12-7-27(20-16(12)19(23)25-8-26-20)13-5-15(18(29)17(13)28)30-14-4-10(22)3-9-1-2-24-6-11(9)14/h3-4,7-8,13,15,17-18,24,28-29H,1-2,5-6H2,(H2,23,25,26)/t13-,15+,17+,18-/m1/s1
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Pfizer Inc.

US Patent


Assay Description
Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...

US Patent US10709709 (2020)


BindingDB Entry DOI: 10.7270/Q26113CC
More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))		BDBM451354
PNG
(US10709709, Example 184 | US10709709, Example 185)
Show SMILES CC1Cc2cccc(O[C@H]3C[C@H]([C@H](O)[C@@H]3O)n3ccc4c(C)ncnc34)c2CN1 |r|
Show InChI InChI=1S/C22H26N4O3/c1-12-8-14-4-3-5-18(16(14)10-23-12)29-19-9-17(20(27)21(19)28)26-7-6-15-13(2)24-11-25-22(15)26/h3-7,11-12,17,19-21,23,27-28H,8-10H2,1-2H3/t12?,17-,19+,20+,21-/m1/s1
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Pfizer Inc.

US Patent


Assay Description
Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...

US Patent US10709709 (2020)


BindingDB Entry DOI: 10.7270/Q26113CC
More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))		BDBM451364
PNG
(US10709709, Example 194)
Show SMILES Cc1ncnc2n(ccc12)[C@@H]1C[C@H](Oc2nc(cc3CCNCc23)C(F)F)[C@@H](O)[C@H]1O |r|
Show InChI InChI=1S/C21H23F2N5O3/c1-10-12-3-5-28(20(12)26-9-25-10)15-7-16(18(30)17(15)29)31-21-13-8-24-4-2-11(13)6-14(27-21)19(22)23/h3,5-6,9,15-19,24,29-30H,2,4,7-8H2,1H3/t15-,16+,17+,18-/m1/s1
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Pfizer Inc.

US Patent


Assay Description
Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...

US Patent US10709709 (2020)


BindingDB Entry DOI: 10.7270/Q26113CC
More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))		BDBM451375
PNG
(US10709709, Example 205)
Show SMILES Cc1ncnc2n(ccc12)[C@@H]1C[C@H](Oc2cc(cc3OCCNCc23)C(F)F)[C@@H](O)[C@H]1O |r|
Show InChI InChI=1S/C22H24F2N4O4/c1-11-13-2-4-28(22(13)27-10-26-11)15-8-18(20(30)19(15)29)32-17-7-12(21(23)24)6-16-14(17)9-25-3-5-31-16/h2,4,6-7,10,15,18-21,25,29-30H,3,5,8-9H2,1H3/t15-,18+,19+,20-/m1/s1
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Pfizer Inc.

US Patent


Assay Description
Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...

US Patent US10709709 (2020)


BindingDB Entry DOI: 10.7270/Q26113CC
More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))		BDBM451380
PNG
(US10709709, Example 210)
Show SMILES C[C@H]1CNCc2c(O[C@H]3C[C@H]([C@H](O)[C@@H]3O)n3ccc4c(C)ncnc34)cccc2O1 |r|
Show InChI InChI=1S/C22H26N4O4/c1-12-9-23-10-15-17(29-12)4-3-5-18(15)30-19-8-16(20(27)21(19)28)26-7-6-14-13(2)24-11-25-22(14)26/h3-7,11-12,16,19-21,23,27-28H,8-10H2,1-2H3/t12-,16+,19-,20-,21+/m0/s1
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Pfizer Inc.

US Patent


Assay Description
Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...

US Patent US10709709 (2020)


BindingDB Entry DOI: 10.7270/Q26113CC
More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))		BDBM50523654
PNG
(CHEMBL4455651 | US10709709, Example 212)
Show SMILES CC1CNCc2c(O[C@H]3C[C@H]([C@H](O)[C@@H]3O)n3ccc4c(C)ncnc34)cc(C(F)F)c(F)c12 |r|
Show InChI InChI=1S/C23H25F3N4O3/c1-10-7-27-8-14-16(5-13(22(25)26)19(24)18(10)14)33-17-6-15(20(31)21(17)32)30-4-3-12-11(2)28-9-29-23(12)30/h3-5,9-10,15,17,20-22,27,31-32H,6-8H2,1-2H3/t10?,15-,17+,20+,21-/m1/s1
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Pfizer Inc.

US Patent


Assay Description
Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...

US Patent US10709709 (2020)


BindingDB Entry DOI: 10.7270/Q26113CC
More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))		BDBM451385
PNG
(US10709709, Example 215 | US10709709, Example 216)
Show SMILES CC1CNCc2c(O[C@H]3C[C@H]([C@H](O)[C@@H]3O)n3cc(F)c4c(N)ncnc34)cc(C(F)F)c(F)c12 |r|
Show InChI InChI=1S/C22H23F4N5O3/c1-8-4-28-5-10-13(2-9(20(25)26)17(24)15(8)10)34-14-3-12(18(32)19(14)33)31-6-11(23)16-21(27)29-7-30-22(16)31/h2,6-8,12,14,18-20,28,32-33H,3-5H2,1H3,(H2,27,29,30)/t8?,12-,14+,18+,19-/m1/s1
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Pfizer Inc.

US Patent


Assay Description
Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...

US Patent US10709709 (2020)


BindingDB Entry DOI: 10.7270/Q26113CC
More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))		BDBM451251
PNG
(US10709709, Example 78)
Show SMILES Cc1ncnc2n(ccc12)C1C[C@H](Oc2cccc3CCNCc23)[C@@H](O)[C@H]1O |r|
Show InChI InChI=1S/C21H24N4O3/c1-12-14-6-8-25(21(14)24-11-23-12)16-9-18(20(27)19(16)26)28-17-4-2-3-13-5-7-22-10-15(13)17/h2-4,6,8,11,16,18-20,22,26-27H,5,7,9-10H2,1H3/t16?,18-,19-,20+/m0/s1
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Pfizer Inc.

US Patent


Assay Description
Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...

US Patent US10709709 (2020)


BindingDB Entry DOI: 10.7270/Q26113CC
More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))		BDBM451275
PNG
(US10709709, Example 102)
Show SMILES Nc1ncnc2n(cc(F)c12)[C@@H]1C[C@H](Oc2cc(Cl)cc3CCNCc23)[C@@H](O)[C@H]1O |r|
Show InChI InChI=1S/C20H21ClFN5O3/c21-10-3-9-1-2-24-6-11(9)14(4-10)30-15-5-13(17(28)18(15)29)27-7-12(22)16-19(23)25-8-26-20(16)27/h3-4,7-8,13,15,17-18,24,28-29H,1-2,5-6H2,(H2,23,25,26)/t13-,15+,17+,18-/m1/s1
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Pfizer Inc.

US Patent


Assay Description
Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...

US Patent US10709709 (2020)


BindingDB Entry DOI: 10.7270/Q26113CC
More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))		BDBM451286
PNG
(US10709709, Example 113)
Show SMILES Cc1cc(O[C@H]2C[C@H]([C@H](O)[C@@H]2O)n2cc(F)c3c(N)ncnc23)c2CNCCc2c1F |r|
Show InChI InChI=1S/C21H23F2N5O3/c1-9-4-14(11-6-25-3-2-10(11)17(9)23)31-15-5-13(18(29)19(15)30)28-7-12(22)16-20(24)26-8-27-21(16)28/h4,7-8,13,15,18-19,25,29-30H,2-3,5-6H2,1H3,(H2,24,26,27)/t13-,15+,18+,19-/m1/s1
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Pfizer Inc.

US Patent


Assay Description
Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...

US Patent US10709709 (2020)


BindingDB Entry DOI: 10.7270/Q26113CC
More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))		BDBM451307
PNG
(US10709709, Example 134)
Show SMILES Nc1ncnc2n(cc(Br)c12)[C@@H]1C[C@H](Oc2ccc(F)c3CCNCc23)[C@@H](O)[C@H]1O |r|
Show InChI InChI=1S/C20H21BrFN5O3/c21-11-7-27(20-16(11)19(23)25-8-26-20)13-5-15(18(29)17(13)28)30-14-2-1-12(22)9-3-4-24-6-10(9)14/h1-2,7-8,13,15,17-18,24,28-29H,3-6H2,(H2,23,25,26)/t13-,15+,17+,18-/m1/s1
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Pfizer Inc.

US Patent


Assay Description
Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...

US Patent US10709709 (2020)


BindingDB Entry DOI: 10.7270/Q26113CC
More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))		BDBM50523649
PNG
(CHEMBL4448266 | US10709709, Example 198)
Show SMILES COc1cc(O[C@H]2C[C@H]([C@H](O)[C@@H]2O)n2ccc3c(C)ncnc23)c2CNCCc2c1F |r|
Show InChI InChI=1S/C22H25FN4O4/c1-11-12-4-6-27(22(12)26-10-25-11)15-7-18(21(29)20(15)28)31-16-8-17(30-2)19(23)13-3-5-24-9-14(13)16/h4,6,8,10,15,18,20-21,24,28-29H,3,5,7,9H2,1-2H3/t15-,18+,20+,21-/m1/s1
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Pfizer Inc.

US Patent


Assay Description
Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...

US Patent US10709709 (2020)


BindingDB Entry DOI: 10.7270/Q26113CC
More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))		BDBM50523638
PNG
(CHEMBL4470815 | US10709709, Example 200)
Show SMILES Cc1ncnc2n(ccc12)[C@@H]1C[C@H](Oc2cc(OC(F)F)c(F)c3CCNCc23)[C@@H](O)[C@H]1O |r|
Show InChI InChI=1S/C22H23F3N4O4/c1-10-11-3-5-29(21(11)28-9-27-10)14-6-17(20(31)19(14)30)32-15-7-16(33-22(24)25)18(23)12-2-4-26-8-13(12)15/h3,5,7,9,14,17,19-20,22,26,30-31H,2,4,6,8H2,1H3/t14-,17+,19+,20-/m1/s1
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Pfizer Inc.

US Patent


Assay Description
Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...

US Patent US10709709 (2020)


BindingDB Entry DOI: 10.7270/Q26113CC
More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))		BDBM451372
PNG
(US10709709, Example 202)
Show SMILES Cc1ncnc2n(ccc12)[C@@H]1C[C@H](Oc2cc(cc3OCCNCc23)C#N)[C@@H](O)[C@H]1O |r|
Show InChI InChI=1S/C22H23N5O4/c1-12-14-2-4-27(22(14)26-11-25-12)16-8-19(21(29)20(16)28)31-18-7-13(9-23)6-17-15(18)10-24-3-5-30-17/h2,4,6-7,11,16,19-21,24,28-29H,3,5,8,10H2,1H3/t16-,19+,20+,21-/m1/s1
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Pfizer Inc.

US Patent


Assay Description
Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...

US Patent US10709709 (2020)


BindingDB Entry DOI: 10.7270/Q26113CC
More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))		BDBM451383
PNG
(US10709709, Example 213 | US10709709, Example 214)
Show SMILES CC1NCCc2c(F)ccc(O[C@H]3C[C@H]([C@H](O)[C@@H]3O)n3ccc4c(C)ncnc34)c12 |r|
Show InChI InChI=1S/C22H25FN4O3/c1-11-13-6-8-27(22(13)26-10-25-11)16-9-18(21(29)20(16)28)30-17-4-3-15(23)14-5-7-24-12(2)19(14)17/h3-4,6,8,10,12,16,18,20-21,24,28-29H,5,7,9H2,1-2H3/t12?,16-,18+,20+,21-/m1/s1
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Pfizer Inc.

US Patent


Assay Description
Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...

US Patent US10709709 (2020)


BindingDB Entry DOI: 10.7270/Q26113CC
More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))		BDBM451267
PNG
(US10709709, Example 94)
Show SMILES Cc1ncnc2n(ccc12)[C@@H]1C[C@H](Oc2cc(Br)c(F)c3CCNCc23)[C@@H](O)[C@H]1O |r|
Show InChI InChI=1S/C21H22BrFN4O3/c1-10-11-3-5-27(21(11)26-9-25-10)15-7-17(20(29)19(15)28)30-16-6-14(22)18(23)12-2-4-24-8-13(12)16/h3,5-6,9,15,17,19-20,24,28-29H,2,4,7-8H2,1H3/t15-,17+,19+,20-/m1/s1
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Pfizer Inc.

US Patent


Assay Description
Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...

US Patent US10709709 (2020)


BindingDB Entry DOI: 10.7270/Q26113CC
More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))		BDBM451273
PNG
(US10709709, Example 100)
Show SMILES Nc1ncnc2n(cc(F)c12)[C@@H]1C[C@H](Oc2ccc(F)c3CCNCc23)[C@@H](O)[C@H]1O |r|
Show InChI InChI=1S/C20H21F2N5O3/c21-11-1-2-14(10-6-24-4-3-9(10)11)30-15-5-13(17(28)18(15)29)27-7-12(22)16-19(23)25-8-26-20(16)27/h1-2,7-8,13,15,17-18,24,28-29H,3-6H2,(H2,23,25,26)/t13-,15+,17+,18-/m1/s1
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Pfizer Inc.

US Patent


Assay Description
Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...

US Patent US10709709 (2020)


BindingDB Entry DOI: 10.7270/Q26113CC
More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))		BDBM451274
PNG
(US10709709, Example 101)
Show SMILES Nc1ncnc2n(cc(F)c12)[C@@H]1C[C@H](Oc2cc(Br)cc3CCNCc23)[C@@H](O)[C@H]1O |r|
Show InChI InChI=1S/C20H21BrFN5O3/c21-10-3-9-1-2-24-6-11(9)14(4-10)30-15-5-13(17(28)18(15)29)27-7-12(22)16-19(23)25-8-26-20(16)27/h3-4,7-8,13,15,17-18,24,28-29H,1-2,5-6H2,(H2,23,25,26)/t13-,15+,17+,18-/m1/s1
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Pfizer Inc.

US Patent


Assay Description
Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...

US Patent US10709709 (2020)


BindingDB Entry DOI: 10.7270/Q26113CC
More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))		BDBM451306
PNG
(US10709709, Example 133)
Show SMILES Nc1ncnc2n(cc(Cl)c12)[C@@H]1C[C@H](Oc2ccc(F)c3CCNCc23)[C@@H](O)[C@H]1O |r|
Show InChI InChI=1S/C20H21ClFN5O3/c21-11-7-27(20-16(11)19(23)25-8-26-20)13-5-15(18(29)17(13)28)30-14-2-1-12(22)9-3-4-24-6-10(9)14/h1-2,7-8,13,15,17-18,24,28-29H,3-6H2,(H2,23,25,26)/t13-,15+,17+,18-/m1/s1
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Pfizer Inc.

US Patent


Assay Description
Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...

US Patent US10709709 (2020)


BindingDB Entry DOI: 10.7270/Q26113CC
More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))		BDBM451353
PNG
(US10709709, Example 183)
Show SMILES C[C@@H]1CNCc2c(O[C@H]3C[C@H]([C@H](O)[C@@H]3O)n3ccc4c(C)ncnc34)ccc(F)c12 |r|
Show InChI InChI=1S/C22H25FN4O3/c1-11-8-24-9-14-17(4-3-15(23)19(11)14)30-18-7-16(20(28)21(18)29)27-6-5-13-12(2)25-10-26-22(13)27/h3-6,10-11,16,18,20-21,24,28-29H,7-9H2,1-2H3/t11-,16-,18+,20+,21-/m1/s1
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Pfizer Inc.

US Patent


Assay Description
Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...

US Patent US10709709 (2020)


BindingDB Entry DOI: 10.7270/Q26113CC
More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))		BDBM451385
PNG
(US10709709, Example 215 | US10709709, Example 216)
Show SMILES CC1CNCc2c(O[C@H]3C[C@H]([C@H](O)[C@@H]3O)n3cc(F)c4c(N)ncnc34)cc(C(F)F)c(F)c12 |r|
Show InChI InChI=1S/C22H23F4N5O3/c1-8-4-28-5-10-13(2-9(20(25)26)17(24)15(8)10)34-14-3-12(18(32)19(14)33)31-6-11(23)16-21(27)29-7-30-22(16)31/h2,6-8,12,14,18-20,28,32-33H,3-5H2,1H3,(H2,27,29,30)/t8?,12-,14+,18+,19-/m1/s1
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Pfizer Inc.

US Patent


Assay Description
Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...

US Patent US10709709 (2020)


BindingDB Entry DOI: 10.7270/Q26113CC
More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))		BDBM451265
PNG
(US10709709, Example 92)
Show SMILES Cc1ncnc2n(ccc12)[C@@H]1C[C@H](Oc2cc(F)c(F)c3CCNCc23)[C@@H](O)[C@H]1O |r|
Show InChI InChI=1S/C21H22F2N4O3/c1-10-11-3-5-27(21(11)26-9-25-10)15-7-17(20(29)19(15)28)30-16-6-14(22)18(23)12-2-4-24-8-13(12)16/h3,5-6,9,15,17,19-20,24,28-29H,2,4,7-8H2,1H3/t15-,17+,19+,20-/m1/s1
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Pfizer Inc.

US Patent


Assay Description
Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...

US Patent US10709709 (2020)


BindingDB Entry DOI: 10.7270/Q26113CC
More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))		BDBM451298
PNG
(US10709709, Example 125)
Show SMILES Nc1ncnc2n(cc(Br)c12)[C@@H]1C[C@H](Oc2cc(F)c(F)c3CCNCc23)[C@@H](O)[C@H]1O |r|
Show InChI InChI=1S/C20H20BrF2N5O3/c21-10-6-28(20-15(10)19(24)26-7-27-20)12-4-14(18(30)17(12)29)31-13-3-11(22)16(23)8-1-2-25-5-9(8)13/h3,6-7,12,14,17-18,25,29-30H,1-2,4-5H2,(H2,24,26,27)/t12-,14+,17+,18-/m1/s1
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Pfizer Inc.

US Patent


Assay Description
Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...

US Patent US10709709 (2020)


BindingDB Entry DOI: 10.7270/Q26113CC
More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%