Found 10 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM101912
(US8536227, 4)Show SMILES Oc1cc(\C=C\C(=S)NCc2cc(O)c(O)c(O)c2Br)cc(Br)c1O Show InChI InChI=1S/C16H13Br2NO5S/c17-9-3-7(4-10(20)14(9)22)1-2-12(25)19-6-8-5-11(21)15(23)16(24)13(8)18/h1-5,20-24H,6H2,(H,19,25)/b2-1+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a | n/a |
Novotyr Therapeutics Ltd.
US Patent
| Assay Description
Inhibition assay using IGF1R activity in a cell free kinase assay. |
US Patent US8536227 (2013)
BindingDB Entry DOI: 10.7270/Q21V5CKM |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM5567
(US8536227, 8)Show SMILES Oc1cc(CNC(=S)\C=C\c2cc(O)c(O)c(Br)c2Br)cc(O)c1O Show InChI InChI=1S/C16H13Br2NO5S/c17-13-8(5-11(22)16(24)14(13)18)1-2-12(25)19-6-7-3-9(20)15(23)10(21)4-7/h1-5,20-24H,6H2,(H,19,25)/b2-1+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 50 | n/a | n/a | n/a | n/a | n/a | n/a |
Novotyr Therapeutics Ltd.
US Patent
| Assay Description
Inhibition assay using IGF1R activity in a cell free kinase assay. |
US Patent US8536227 (2013)
BindingDB Entry DOI: 10.7270/Q21V5CKM |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM101913
(US8536227, 5)Show SMILES Oc1ccc(\C=C\C(=S)NCc2cc(O)c(O)c(O)c2)c(Br)c1O Show InChI InChI=1S/C16H14BrNO5S/c17-14-9(1-3-10(19)16(14)23)2-4-13(24)18-7-8-5-11(20)15(22)12(21)6-8/h1-6,19-23H,7H2,(H,18,24)/b4-2+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
MCE
PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 70 | n/a | n/a | n/a | n/a | n/a | n/a |
Novotyr Therapeutics Ltd.
US Patent
| Assay Description
Inhibition assay using IGF1R activity in a cell free kinase assay. |
US Patent US8536227 (2013)
BindingDB Entry DOI: 10.7270/Q21V5CKM |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM101914
(US8536227, 6)Show SMILES Oc1cc(Br)c(\C=C\C(=S)NCc2cc(O)c(O)c(O)c2)cc1O Show InChI InChI=1S/C16H14BrNO5S/c17-10-6-12(20)11(19)5-9(10)1-2-15(24)18-7-8-3-13(21)16(23)14(22)4-8/h1-6,19-23H,7H2,(H,18,24)/b2-1+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 80 | n/a | n/a | n/a | n/a | n/a | n/a |
Novotyr Therapeutics Ltd.
US Patent
| Assay Description
Inhibition assay using IGF1R activity in a cell free kinase assay. |
US Patent US8536227 (2013)
BindingDB Entry DOI: 10.7270/Q21V5CKM |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM101916
(US8536227, 10)Show SMILES Oc1ccc(CNC(=S)\C=C\c2cc(O)c(O)c(Br)c2)c(O)c1O Show InChI InChI=1S/C16H14BrNO5S/c17-10-5-8(6-12(20)15(10)22)1-4-13(24)18-7-9-2-3-11(19)16(23)14(9)21/h1-6,19-23H,7H2,(H,18,24)/b4-1+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 90 | n/a | n/a | n/a | n/a | n/a | n/a |
Novotyr Therapeutics Ltd.
US Patent
| Assay Description
Inhibition assay using IGF1R activity in a cell free kinase assay. |
US Patent US8536227 (2013)
BindingDB Entry DOI: 10.7270/Q21V5CKM |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM5846
(US8536227, 12)Show SMILES CC(NC(=S)\C=C\c1ccc(O)c(O)c1Br)c1cc(O)c(O)c(O)c1 Show InChI InChI=1S/C17H16BrNO5S/c1-8(10-6-12(21)16(23)13(22)7-10)19-14(25)5-3-9-2-4-11(20)17(24)15(9)18/h2-8,20-24H,1H3,(H,19,25)/b5-3+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 120 | n/a | n/a | n/a | n/a | n/a | n/a |
Novotyr Therapeutics Ltd.
US Patent
| Assay Description
Inhibition assay using IGF1R activity in a cell free kinase assay. |
US Patent US8536227 (2013)
BindingDB Entry DOI: 10.7270/Q21V5CKM |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM101917
(US8536227, 11)Show SMILES Oc1ccc(\C=C\C(=S)NCc2cc(O)c(O)c(O)c2)c(Cl)c1O Show InChI InChI=1S/C16H14ClNO5S/c17-14-9(1-3-10(19)16(14)23)2-4-13(24)18-7-8-5-11(20)15(22)12(21)6-8/h1-6,19-23H,7H2,(H,18,24)/b4-2+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 140 | n/a | n/a | n/a | n/a | n/a | n/a |
Novotyr Therapeutics Ltd.
US Patent
| Assay Description
Inhibition assay using IGF1R activity in a cell free kinase assay. |
US Patent US8536227 (2013)
BindingDB Entry DOI: 10.7270/Q21V5CKM |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM5720
(US8536227, 9)Show SMILES CN(Cc1cc(O)c(O)c(O)c1)C(=S)\C=C\c1cc(O)c(O)c(Br)c1 Show InChI InChI=1S/C17H16BrNO5S/c1-19(8-10-6-13(21)17(24)14(22)7-10)15(25)3-2-9-4-11(18)16(23)12(20)5-9/h2-7,20-24H,8H2,1H3/b3-2+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 170 | n/a | n/a | n/a | n/a | n/a | n/a |
Novotyr Therapeutics Ltd.
US Patent
| Assay Description
Inhibition assay using IGF1R activity in a cell free kinase assay. |
US Patent US8536227 (2013)
BindingDB Entry DOI: 10.7270/Q21V5CKM |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM101915
(US8536227, 7)Show SMILES Oc1ccc(\C=C\C(=S)NCc2cc(O)c(O)c(O)c2)c(I)c1O Show InChI InChI=1S/C16H14INO5S/c17-14-9(1-3-10(19)16(14)23)2-4-13(24)18-7-8-5-11(20)15(22)12(21)6-8/h1-6,19-23H,7H2,(H,18,24)/b4-2+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 180 | n/a | n/a | n/a | n/a | n/a | n/a |
Novotyr Therapeutics Ltd.
US Patent
| Assay Description
Inhibition assay using IGF1R activity in a cell free kinase assay. |
US Patent US8536227 (2013)
BindingDB Entry DOI: 10.7270/Q21V5CKM |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM5921
(US8536227, 13)Show SMILES C\C(=C/C(=S)NCc1cc(O)c(O)c(O)c1)c1cc(O)c(O)c(Br)c1 Show InChI InChI=1S/C17H16BrNO5S/c1-8(10-5-11(18)16(23)14(22)6-10)2-15(25)19-7-9-3-12(20)17(24)13(21)4-9/h2-6,20-24H,7H2,1H3,(H,19,25)/b8-2+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 220 | n/a | n/a | n/a | n/a | n/a | n/a |
Novotyr Therapeutics Ltd.
US Patent
| Assay Description
Inhibition assay using IGF1R activity in a cell free kinase assay. |
US Patent US8536227 (2013)
BindingDB Entry DOI: 10.7270/Q21V5CKM |
More data for this
Ligand-Target Pair | |
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