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Patent code US8618111

Compile Data Set for Download or QSAR

Found 284 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))		BDBM111716
PNG
(US8618111, G-1)
Show SMILES CCc1ncnc(N2CCN(CC2)C(=O)NC)c1C#Cc1ccc(N)nc1
Show InChI InChI=1S/C19H23N7O/c1-3-16-15(6-4-14-5-7-17(20)22-12-14)18(24-13-23-16)25-8-10-26(11-9-25)19(27)21-2/h5,7,12-13H,3,8-11H2,1-2H3,(H2,20,22)(H,21,27)
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n/an/a 33n/an/an/an/a7.50



Boehringer Ingelheim International GmbH

US Patent


Assay Description
PI3Kalpha assay described herein provides IC50 values indicating the activity of the compounds inhibiting PI3 kinase alpha activity Inhibition of PI3...

US Patent US8618111 (2013)


BindingDB Entry DOI: 10.7270/Q2FX7838
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))		BDBM111721
PNG
(US8618111, G-6)
Show SMILES CCc1ncnc(N2CCN(CC2)C(=O)OC)c1C#Cc1ccc(N)nc1
Show InChI InChI=1S/C19H22N6O2/c1-3-16-15(6-4-14-5-7-17(20)21-12-14)18(23-13-22-16)24-8-10-25(11-9-24)19(26)27-2/h5,7,12-13H,3,8-11H2,1-2H3,(H2,20,21)
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n/an/a 52n/an/an/an/a7.50



Boehringer Ingelheim International GmbH

US Patent


Assay Description
PI3Kalpha assay described herein provides IC50 values indicating the activity of the compounds inhibiting PI3 kinase alpha activity Inhibition of PI3...

US Patent US8618111 (2013)


BindingDB Entry DOI: 10.7270/Q2FX7838
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))		BDBM111729
PNG
(US8618111, H-1)
Show SMILES CCc1ncnc(N2CCCCC2)c1C#Cc1ccc(NC)nc1
Show InChI InChI=1S/C19H23N5/c1-3-17-16(9-7-15-8-10-18(20-2)21-13-15)19(23-14-22-17)24-11-5-4-6-12-24/h8,10,13-14H,3-6,11-12H2,1-2H3,(H,20,21)
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n/an/a 214n/an/an/an/a7.50



Boehringer Ingelheim International GmbH

US Patent


Assay Description
PI3Kalpha assay described herein provides IC50 values indicating the activity of the compounds inhibiting PI3 kinase alpha activity Inhibition of PI3...

US Patent US8618111 (2013)


BindingDB Entry DOI: 10.7270/Q2FX7838
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))		BDBM111753
PNG
(US8618111, H-26)
Show SMILES CCc1ncnc(N2CCN(CC2)C2COC2)c1C#Cc1ccc(N)nc1
Show InChI InChI=1S/C20H24N6O/c1-2-18-17(5-3-15-4-6-19(21)22-11-15)20(24-14-23-18)26-9-7-25(8-10-26)16-12-27-13-16/h4,6,11,14,16H,2,7-10,12-13H2,1H3,(H2,21,22)
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n/an/a 105n/an/an/an/a7.50



Boehringer Ingelheim International GmbH

US Patent


Assay Description
PI3Kalpha assay described herein provides IC50 values indicating the activity of the compounds inhibiting PI3 kinase alpha activity Inhibition of PI3...

US Patent US8618111 (2013)


BindingDB Entry DOI: 10.7270/Q2FX7838
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))		BDBM111647
PNG
(US8618111, B-34)
Show SMILES CCc1ncnc(N2CCC(O)(CC)CC2)c1C#Cc1ccc(N)nc1
Show InChI InChI=1S/C20H25N5O/c1-3-17-16(7-5-15-6-8-18(21)22-13-15)19(24-14-23-17)25-11-9-20(26,4-2)10-12-25/h6,8,13-14,26H,3-4,9-12H2,1-2H3,(H2,21,22)
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n/an/a 15n/an/an/an/a7.50



Boehringer Ingelheim International GmbH

US Patent


Assay Description
PI3Kalpha assay described herein provides IC50 values indicating the activity of the compounds inhibiting PI3 kinase alpha activity Inhibition of PI3...

US Patent US8618111 (2013)


BindingDB Entry DOI: 10.7270/Q2FX7838
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))		BDBM111649
PNG
(US8618111, B-36)
Show SMILES CCC1(O)CCN(CC1)c1ncnc(C)c1C#Cc1ccc(N)nc1
Show InChI InChI=1S/C19H23N5O/c1-3-19(25)8-10-24(11-9-19)18-16(14(2)22-13-23-18)6-4-15-5-7-17(20)21-12-15/h5,7,12-13,25H,3,8-11H2,1-2H3,(H2,20,21)
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n/an/a 50n/an/an/an/a7.50



Boehringer Ingelheim International GmbH

US Patent


Assay Description
PI3Kalpha assay described herein provides IC50 values indicating the activity of the compounds inhibiting PI3 kinase alpha activity Inhibition of PI3...

US Patent US8618111 (2013)


BindingDB Entry DOI: 10.7270/Q2FX7838
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))		BDBM111636
PNG
(US8618111, B-23 | US8618111, B-47)
Show SMILES CCc1ncnc(N2CCC(C)(O)CC2)c1C#Cc1ccc(N)nc1
Show InChI InChI=1S/C19H23N5O/c1-3-16-15(6-4-14-5-7-17(20)21-12-14)18(23-13-22-16)24-10-8-19(2,25)9-11-24/h5,7,12-13,25H,3,8-11H2,1-2H3,(H2,20,21)
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n/an/a 36n/an/an/an/a7.50



Boehringer Ingelheim International GmbH

US Patent


Assay Description
PI3Kalpha assay described herein provides IC50 values indicating the activity of the compounds inhibiting PI3 kinase alpha activity Inhibition of PI3...

US Patent US8618111 (2013)


BindingDB Entry DOI: 10.7270/Q2FX7838
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))		BDBM111678
PNG
(US8618111, B-65)
Show SMILES Cc1ncnc(N2CCC(=O)CC2)c1C#Cc1ccc(N)nc1
Show InChI InChI=1S/C17H17N5O/c1-12-15(4-2-13-3-5-16(18)19-10-13)17(21-11-20-12)22-8-6-14(23)7-9-22/h3,5,10-11H,6-9H2,1H3,(H2,18,19)
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n/an/a 104n/an/an/an/a7.50



Boehringer Ingelheim International GmbH

US Patent


Assay Description
PI3Kalpha assay described herein provides IC50 values indicating the activity of the compounds inhibiting PI3 kinase alpha activity Inhibition of PI3...

US Patent US8618111 (2013)


BindingDB Entry DOI: 10.7270/Q2FX7838
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))		BDBM111689
PNG
(US8618111, B-76)
Show SMILES Cc1cnc2CN(CCn12)c1ncnc(C)c1C#Cc1ccc(N)nc1
Show InChI InChI=1S/C19H19N7/c1-13-9-22-18-11-25(7-8-26(13)18)19-16(14(2)23-12-24-19)5-3-15-4-6-17(20)21-10-15/h4,6,9-10,12H,7-8,11H2,1-2H3,(H2,20,21)
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n/an/a 60n/an/an/an/a7.50



Boehringer Ingelheim International GmbH

US Patent


Assay Description
PI3Kalpha assay described herein provides IC50 values indicating the activity of the compounds inhibiting PI3 kinase alpha activity Inhibition of PI3...

US Patent US8618111 (2013)


BindingDB Entry DOI: 10.7270/Q2FX7838
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))		BDBM111693
PNG
(US8618111, B-80)
Show SMILES CN1CCC2(CC1)CCN(CC2)c1ncnc(C)c1C#Cc1ccc(N)nc1
Show InChI InChI=1S/C22H28N6/c1-17-19(5-3-18-4-6-20(23)24-15-18)21(26-16-25-17)28-13-9-22(10-14-28)7-11-27(2)12-8-22/h4,6,15-16H,7-14H2,1-2H3,(H2,23,24)
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n/an/a 99n/an/an/an/a7.50



Boehringer Ingelheim International GmbH

US Patent


Assay Description
PI3Kalpha assay described herein provides IC50 values indicating the activity of the compounds inhibiting PI3 kinase alpha activity Inhibition of PI3...

US Patent US8618111 (2013)


BindingDB Entry DOI: 10.7270/Q2FX7838
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))		BDBM111711
PNG
(US8618111, F-3)
Show SMILES Cc1ncnc(N2CCC(CNC(=O)CC3CCCC3)CC2)c1C#Cc1ccc(N)nc1
Show InChI InChI=1S/C25H32N6O/c1-18-22(8-6-20-7-9-23(26)27-15-20)25(30-17-29-18)31-12-10-21(11-13-31)16-28-24(32)14-19-4-2-3-5-19/h7,9,15,17,19,21H,2-5,10-14,16H2,1H3,(H2,26,27)(H,28,32)
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n/an/a 39n/an/an/an/a7.50



Boehringer Ingelheim International GmbH

US Patent


Assay Description
PI3Kalpha assay described herein provides IC50 values indicating the activity of the compounds inhibiting PI3 kinase alpha activity Inhibition of PI3...

US Patent US8618111 (2013)


BindingDB Entry DOI: 10.7270/Q2FX7838
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))		BDBM111715
PNG
(US8618111, F-7)
Show SMILES CC(C)CC(=O)NCC1CCN(CC1)c1ncnc(C)c1C#Cc1ccc(N)nc1
Show InChI InChI=1S/C23H30N6O/c1-16(2)12-22(30)26-14-19-8-10-29(11-9-19)23-20(17(3)27-15-28-23)6-4-18-5-7-21(24)25-13-18/h5,7,13,15-16,19H,8-12,14H2,1-3H3,(H2,24,25)(H,26,30)
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n/an/a 47n/an/an/an/a7.50



Boehringer Ingelheim International GmbH

US Patent


Assay Description
PI3Kalpha assay described herein provides IC50 values indicating the activity of the compounds inhibiting PI3 kinase alpha activity Inhibition of PI3...

US Patent US8618111 (2013)


BindingDB Entry DOI: 10.7270/Q2FX7838
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))		BDBM111743
PNG
(US8618111, H-16)
Show SMILES CCc1ncnc(N2CCN(CC2)C(=O)N2CCOCC2)c1C#Cc1ccc(N)nc1
Show InChI InChI=1S/C22H27N7O2/c1-2-19-18(5-3-17-4-6-20(23)24-15-17)21(26-16-25-19)27-7-9-28(10-8-27)22(30)29-11-13-31-14-12-29/h4,6,15-16H,2,7-14H2,1H3,(H2,23,24)
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n/an/a 116n/an/an/an/a7.50



Boehringer Ingelheim International GmbH

US Patent


Assay Description
PI3Kalpha assay described herein provides IC50 values indicating the activity of the compounds inhibiting PI3 kinase alpha activity Inhibition of PI3...

US Patent US8618111 (2013)


BindingDB Entry DOI: 10.7270/Q2FX7838
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))		BDBM111745
PNG
(US8618111, H-18)
Show SMILES CCc1ncnc(N2CCc3cc(OC)c(OC)cc3C2)c1C#Cc1ccc(N)nc1
Show InChI InChI=1S/C24H25N5O2/c1-4-20-19(7-5-16-6-8-23(25)26-13-16)24(28-15-27-20)29-10-9-17-11-21(30-2)22(31-3)12-18(17)14-29/h6,8,11-13,15H,4,9-10,14H2,1-3H3,(H2,25,26)
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n/an/a 43n/an/an/an/a7.50



Boehringer Ingelheim International GmbH

US Patent


Assay Description
PI3Kalpha assay described herein provides IC50 values indicating the activity of the compounds inhibiting PI3 kinase alpha activity Inhibition of PI3...

US Patent US8618111 (2013)


BindingDB Entry DOI: 10.7270/Q2FX7838
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))		BDBM111736
PNG
(US8618111, H-8)
Show SMILES CCc1ncnc(N2CCN(CCN3CCOCC3)CC2)c1C#Cc1ccc(N)nc1
Show InChI InChI=1S/C23H31N7O/c1-2-21-20(5-3-19-4-6-22(24)25-17-19)23(27-18-26-21)30-11-9-28(10-12-30)7-8-29-13-15-31-16-14-29/h4,6,17-18H,2,7-16H2,1H3,(H2,24,25)
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n/an/a 185n/an/an/an/a7.50



Boehringer Ingelheim International GmbH

US Patent


Assay Description
PI3Kalpha assay described herein provides IC50 values indicating the activity of the compounds inhibiting PI3 kinase alpha activity Inhibition of PI3...

US Patent US8618111 (2013)


BindingDB Entry DOI: 10.7270/Q2FX7838
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))		BDBM111744
PNG
(US8618111, H-17)
Show SMILES CCc1ncnc(N2CCc3ccccc3C2)c1C#Cc1ccc(N)nc1
Show InChI InChI=1S/C22H21N5/c1-2-20-19(9-7-16-8-10-21(23)24-13-16)22(26-15-25-20)27-12-11-17-5-3-4-6-18(17)14-27/h3-6,8,10,13,15H,2,11-12,14H2,1H3,(H2,23,24)
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n/an/a 56n/an/an/an/a7.50



Boehringer Ingelheim International GmbH

US Patent


Assay Description
PI3Kalpha assay described herein provides IC50 values indicating the activity of the compounds inhibiting PI3 kinase alpha activity Inhibition of PI3...

US Patent US8618111 (2013)


BindingDB Entry DOI: 10.7270/Q2FX7838
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))		BDBM111755
PNG
(US8618111, H-28)
Show SMILES CCc1ncnc(N2CCN(Cc3nc(C)c(C)o3)CC2)c1C#Cc1ccc(N)nc1
Show InChI InChI=1S/C23H27N7O/c1-4-20-19(7-5-18-6-8-21(24)25-13-18)23(27-15-26-20)30-11-9-29(10-12-30)14-22-28-16(2)17(3)31-22/h6,8,13,15H,4,9-12,14H2,1-3H3,(H2,24,25)
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n/an/a 232n/an/an/an/a7.50



Boehringer Ingelheim International GmbH

US Patent


Assay Description
PI3Kalpha assay described herein provides IC50 values indicating the activity of the compounds inhibiting PI3 kinase alpha activity Inhibition of PI3...

US Patent US8618111 (2013)


BindingDB Entry DOI: 10.7270/Q2FX7838
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))		BDBM111632
PNG
(US8618111, B-19)
Show SMILES CCc1ncnc(N2CCC(O)(CC2)C(F)(F)F)c1C#Cc1ccc(N)nc1
Show InChI InChI=1S/C19H20F3N5O/c1-2-15-14(5-3-13-4-6-16(23)24-11-13)17(26-12-25-15)27-9-7-18(28,8-10-27)19(20,21)22/h4,6,11-12,28H,2,7-10H2,1H3,(H2,23,24)
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n/an/a 53n/an/an/an/a7.50



Boehringer Ingelheim International GmbH

US Patent


Assay Description
PI3Kalpha assay described herein provides IC50 values indicating the activity of the compounds inhibiting PI3 kinase alpha activity Inhibition of PI3...

US Patent US8618111 (2013)


BindingDB Entry DOI: 10.7270/Q2FX7838
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))		BDBM111634
PNG
(US8618111, B-21)
Show SMILES CCc1ncnc(N2CCC(CC2)NC(C)=O)c1C#Cc1ccc(N)nc1
Show InChI InChI=1S/C20H24N6O/c1-3-18-17(6-4-15-5-7-19(21)22-12-15)20(24-13-23-18)26-10-8-16(9-11-26)25-14(2)27/h5,7,12-13,16H,3,8-11H2,1-2H3,(H2,21,22)(H,25,27)
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n/an/a 83n/an/an/an/a7.50



Boehringer Ingelheim International GmbH

US Patent


Assay Description
PI3Kalpha assay described herein provides IC50 values indicating the activity of the compounds inhibiting PI3 kinase alpha activity Inhibition of PI3...

US Patent US8618111 (2013)


BindingDB Entry DOI: 10.7270/Q2FX7838
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))		BDBM111700
PNG
(US8618111, B-87)
Show SMILES CCc1ncnc(N2CCC(O)CC2)c1C#Cc1ccc(NC)nc1
Show InChI InChI=1S/C19H23N5O/c1-3-17-16(6-4-14-5-7-18(20-2)21-12-14)19(23-13-22-17)24-10-8-15(25)9-11-24/h5,7,12-13,15,25H,3,8-11H2,1-2H3,(H,20,21)
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n/an/a 76n/an/an/an/a7.50



Boehringer Ingelheim International GmbH

US Patent


Assay Description
PI3Kalpha assay described herein provides IC50 values indicating the activity of the compounds inhibiting PI3 kinase alpha activity Inhibition of PI3...

US Patent US8618111 (2013)


BindingDB Entry DOI: 10.7270/Q2FX7838
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))		BDBM111706
PNG
(US8618111, E-6)
Show SMILES Cc1ncnc(N2CCC(CC(=O)N3CCOCC3)CC2)c1C#Cc1ccc(N)nc1
Show InChI InChI=1S/C23H28N6O2/c1-17-20(4-2-19-3-5-21(24)25-15-19)23(27-16-26-17)29-8-6-18(7-9-29)14-22(30)28-10-12-31-13-11-28/h3,5,15-16,18H,6-14H2,1H3,(H2,24,25)
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n/an/a 83n/an/an/an/a7.50



Boehringer Ingelheim International GmbH

US Patent


Assay Description
PI3Kalpha assay described herein provides IC50 values indicating the activity of the compounds inhibiting PI3 kinase alpha activity Inhibition of PI3...

US Patent US8618111 (2013)


BindingDB Entry DOI: 10.7270/Q2FX7838
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))		BDBM111724
PNG
(US8618111, G-9)
Show SMILES Cc1ncnc(N2CCN(CC2)C(=O)c2ccno2)c1C#Cc1ccc(N)nc1
Show InChI InChI=1S/C20H19N7O2/c1-14-16(4-2-15-3-5-18(21)22-12-15)19(24-13-23-14)26-8-10-27(11-9-26)20(28)17-6-7-25-29-17/h3,5-7,12-13H,8-11H2,1H3,(H2,21,22)
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n/an/a 39n/an/an/an/a7.50



Boehringer Ingelheim International GmbH

US Patent


Assay Description
PI3Kalpha assay described herein provides IC50 values indicating the activity of the compounds inhibiting PI3 kinase alpha activity Inhibition of PI3...

US Patent US8618111 (2013)


BindingDB Entry DOI: 10.7270/Q2FX7838
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))		BDBM111728
PNG
(US8618111, G-13)
Show SMILES CCc1ncnc(N2CCC3(CCN(CC3)C(=O)NC)CC2)c1C#Cc1ccc(N)nc1
Show InChI InChI=1S/C24H31N7O/c1-3-20-19(6-4-18-5-7-21(25)27-16-18)22(29-17-28-20)30-12-8-24(9-13-30)10-14-31(15-11-24)23(32)26-2/h5,7,16-17H,3,8-15H2,1-2H3,(H2,25,27)(H,26,32)
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n/an/a 50n/an/an/an/a7.50



Boehringer Ingelheim International GmbH

US Patent


Assay Description
PI3Kalpha assay described herein provides IC50 values indicating the activity of the compounds inhibiting PI3 kinase alpha activity Inhibition of PI3...

US Patent US8618111 (2013)


BindingDB Entry DOI: 10.7270/Q2FX7838
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))		BDBM111625
PNG
(US8618111, B-12)
Show SMILES CCc1ncnc(N2CCC(O)(CC2)C2CCCCC2)c1C#Cc1ccc(N)nc1
Show InChI InChI=1S/C24H31N5O/c1-2-21-20(10-8-18-9-11-22(25)26-16-18)23(28-17-27-21)29-14-12-24(30,13-15-29)19-6-4-3-5-7-19/h9,11,16-17,19,30H,2-7,12-15H2,1H3,(H2,25,26)
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n/an/a 189n/an/an/an/a7.50



Boehringer Ingelheim International GmbH

US Patent


Assay Description
PI3Kalpha assay described herein provides IC50 values indicating the activity of the compounds inhibiting PI3 kinase alpha activity Inhibition of PI3...

US Patent US8618111 (2013)


BindingDB Entry DOI: 10.7270/Q2FX7838
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))		BDBM111642
PNG
(US8618111, B-29)
Show SMILES CCc1ncnc(N2CCC(CCO)CC2)c1C#Cc1ccc(C)nc1
Show InChI InChI=1S/C21H26N4O/c1-3-20-19(7-6-18-5-4-16(2)22-14-18)21(24-15-23-20)25-11-8-17(9-12-25)10-13-26/h4-5,14-15,17,26H,3,8-13H2,1-2H3
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n/an/a 88n/an/an/an/a7.50



Boehringer Ingelheim International GmbH

US Patent


Assay Description
PI3Kalpha assay described herein provides IC50 values indicating the activity of the compounds inhibiting PI3 kinase alpha activity Inhibition of PI3...

US Patent US8618111 (2013)


BindingDB Entry DOI: 10.7270/Q2FX7838
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))		BDBM111646
PNG
(US8618111, B-33)
Show SMILES CCc1ncnc(N2CCC(O)(CC)CC2)c1C#Cc1ccc(C)nc1
Show InChI InChI=1S/C21H26N4O/c1-4-19-18(9-8-17-7-6-16(3)22-14-17)20(24-15-23-19)25-12-10-21(26,5-2)11-13-25/h6-7,14-15,26H,4-5,10-13H2,1-3H3
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n/an/a 102n/an/an/an/a7.50



Boehringer Ingelheim International GmbH

US Patent


Assay Description
PI3Kalpha assay described herein provides IC50 values indicating the activity of the compounds inhibiting PI3 kinase alpha activity Inhibition of PI3...

US Patent US8618111 (2013)


BindingDB Entry DOI: 10.7270/Q2FX7838
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))		BDBM111650
PNG
(US8618111, B-37)
Show SMILES CCc1ncnc(N2CCC(CC2)OCCOC)c1C#Cc1ccc(N)nc1
Show InChI InChI=1S/C21H27N5O2/c1-3-19-18(6-4-16-5-7-20(22)23-14-16)21(25-15-24-19)26-10-8-17(9-11-26)28-13-12-27-2/h5,7,14-15,17H,3,8-13H2,1-2H3,(H2,22,23)
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n/an/a 89n/an/an/an/a7.50



Boehringer Ingelheim International GmbH

US Patent


Assay Description
PI3Kalpha assay described herein provides IC50 values indicating the activity of the compounds inhibiting PI3 kinase alpha activity Inhibition of PI3...

US Patent US8618111 (2013)


BindingDB Entry DOI: 10.7270/Q2FX7838
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))		BDBM111661
PNG
(US8618111, B-48)
Show SMILES CCc1ncnc(N2CCC(O)CC2)c1C#Cc1ccc(N)nc1
Show InChI InChI=1S/C18H21N5O/c1-2-16-15(5-3-13-4-6-17(19)20-11-13)18(22-12-21-16)23-9-7-14(24)8-10-23/h4,6,11-12,14,24H,2,7-10H2,1H3,(H2,19,20)
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n/an/a 99n/an/an/an/a7.50



Boehringer Ingelheim International GmbH

US Patent


Assay Description
PI3Kalpha assay described herein provides IC50 values indicating the activity of the compounds inhibiting PI3 kinase alpha activity Inhibition of PI3...

US Patent US8618111 (2013)


BindingDB Entry DOI: 10.7270/Q2FX7838
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))		BDBM111663
PNG
(US8618111, B-50)
Show SMILES CCc1ncnc(N2CCOC(C)(C)C2)c1C#Cc1ccc(N)nc1
Show InChI InChI=1S/C19H23N5O/c1-4-16-15(7-5-14-6-8-17(20)21-11-14)18(23-13-22-16)24-9-10-25-19(2,3)12-24/h6,8,11,13H,4,9-10,12H2,1-3H3,(H2,20,21)
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n/an/a 49n/an/an/an/a7.50



Boehringer Ingelheim International GmbH

US Patent


Assay Description
PI3Kalpha assay described herein provides IC50 values indicating the activity of the compounds inhibiting PI3 kinase alpha activity Inhibition of PI3...

US Patent US8618111 (2013)


BindingDB Entry DOI: 10.7270/Q2FX7838
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))		BDBM111664
PNG
(US8618111, B-51)
Show SMILES CCc1ncnc(N2CCN(CC2)C2CC2)c1C#Cc1ccc(N)nc1
Show InChI InChI=1S/C20H24N6/c1-2-18-17(7-3-15-4-8-19(21)22-13-15)20(24-14-23-18)26-11-9-25(10-12-26)16-5-6-16/h4,8,13-14,16H,2,5-6,9-12H2,1H3,(H2,21,22)
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n/an/a 86n/an/an/an/a7.50



Boehringer Ingelheim International GmbH

US Patent


Assay Description
PI3Kalpha assay described herein provides IC50 values indicating the activity of the compounds inhibiting PI3 kinase alpha activity Inhibition of PI3...

US Patent US8618111 (2013)


BindingDB Entry DOI: 10.7270/Q2FX7838
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))		BDBM111671
PNG
(US8618111, B-58)
Show SMILES CCc1ncnc(N2CCCC2)c1C#Cc1ccc(N)nc1
Show InChI InChI=1S/C17H19N5/c1-2-15-14(7-5-13-6-8-16(18)19-11-13)17(21-12-20-15)22-9-3-4-10-22/h6,8,11-12H,2-4,9-10H2,1H3,(H2,18,19)
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n/an/a 131n/an/an/an/a7.50



Boehringer Ingelheim International GmbH

US Patent


Assay Description
PI3Kalpha assay described herein provides IC50 values indicating the activity of the compounds inhibiting PI3 kinase alpha activity Inhibition of PI3...

US Patent US8618111 (2013)


BindingDB Entry DOI: 10.7270/Q2FX7838
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))		BDBM111690
PNG
(US8618111, B-77)
Show SMILES CCc1ncnc(N2CCC3(CCN(C)C3=O)CC2)c1C#Cc1ccc(N)nc1
Show InChI InChI=1S/C22H26N6O/c1-3-18-17(6-4-16-5-7-19(23)24-14-16)20(26-15-25-18)28-12-9-22(10-13-28)8-11-27(2)21(22)29/h5,7,14-15H,3,8-13H2,1-2H3,(H2,23,24)
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n/an/a 67n/an/an/an/a7.50



Boehringer Ingelheim International GmbH

US Patent


Assay Description
PI3Kalpha assay described herein provides IC50 values indicating the activity of the compounds inhibiting PI3 kinase alpha activity Inhibition of PI3...

US Patent US8618111 (2013)


BindingDB Entry DOI: 10.7270/Q2FX7838
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))		BDBM111694
PNG
(US8618111, B-81)
Show SMILES CCc1ncnc(N2CCN(CC(C)(C)O)CC2)c1C#Cc1ccc(N)nc1
Show InChI InChI=1S/C21H28N6O/c1-4-18-17(7-5-16-6-8-19(22)23-13-16)20(25-15-24-18)27-11-9-26(10-12-27)14-21(2,3)28/h6,8,13,15,28H,4,9-12,14H2,1-3H3,(H2,22,23)
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n/an/a 143n/an/an/an/a7.50



Boehringer Ingelheim International GmbH

US Patent


Assay Description
PI3Kalpha assay described herein provides IC50 values indicating the activity of the compounds inhibiting PI3 kinase alpha activity Inhibition of PI3...

US Patent US8618111 (2013)


BindingDB Entry DOI: 10.7270/Q2FX7838
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))		BDBM111723
PNG
(US8618111, G-8)
Show SMILES Cc1ncnc(N2CCN(CC2)C(=O)C2CCC2)c1C#Cc1ccc(N)nc1
Show InChI InChI=1S/C21H24N6O/c1-15-18(7-5-16-6-8-19(22)23-13-16)20(25-14-24-15)26-9-11-27(12-10-26)21(28)17-3-2-4-17/h6,8,13-14,17H,2-4,9-12H2,1H3,(H2,22,23)
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n/an/a 22n/an/an/an/a7.50



Boehringer Ingelheim International GmbH

US Patent


Assay Description
PI3Kalpha assay described herein provides IC50 values indicating the activity of the compounds inhibiting PI3 kinase alpha activity Inhibition of PI3...

US Patent US8618111 (2013)


BindingDB Entry DOI: 10.7270/Q2FX7838
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))		BDBM111731
PNG
(US8618111, H-3)
Show SMILES CCc1ncnc(N2CCC3(CCCCC3)CC2)c1C#Cc1ccc(N)nc1
Show InChI InChI=1S/C23H29N5/c1-2-20-19(8-6-18-7-9-21(24)25-16-18)22(27-17-26-20)28-14-12-23(13-15-28)10-4-3-5-11-23/h7,9,16-17H,2-5,10-15H2,1H3,(H2,24,25)
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n/an/a 369n/an/an/an/a7.50



Boehringer Ingelheim International GmbH

US Patent


Assay Description
PI3Kalpha assay described herein provides IC50 values indicating the activity of the compounds inhibiting PI3 kinase alpha activity Inhibition of PI3...

US Patent US8618111 (2013)


BindingDB Entry DOI: 10.7270/Q2FX7838
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))		BDBM111676
PNG
(US8618111, B-63)
Show SMILES CCc1ncnc(N2CCC(O)(CC2)C(C)C)c1C#Cc1ccc(N)nc1
Show InChI InChI=1S/C21H27N5O/c1-4-18-17(7-5-16-6-8-19(22)23-13-16)20(25-14-24-18)26-11-9-21(27,10-12-26)15(2)3/h6,8,13-15,27H,4,9-12H2,1-3H3,(H2,22,23)
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n/an/a 15n/an/an/an/a7.50



Boehringer Ingelheim International GmbH

US Patent


Assay Description
PI3Kalpha assay described herein provides IC50 values indicating the activity of the compounds inhibiting PI3 kinase alpha activity Inhibition of PI3...

US Patent US8618111 (2013)


BindingDB Entry DOI: 10.7270/Q2FX7838
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))		BDBM111741
PNG
(US8618111, H-14)
Show SMILES CCc1ncnc(N2CCN(CCNS(C)(=O)=O)CC2)c1C#Cc1ccc(N)nc1
Show InChI InChI=1S/C20H27N7O2S/c1-3-18-17(6-4-16-5-7-19(21)22-14-16)20(24-15-23-18)27-12-10-26(11-13-27)9-8-25-30(2,28)29/h5,7,14-15,25H,3,8-13H2,1-2H3,(H2,21,22)
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n/an/a 60n/an/an/an/a7.50



Boehringer Ingelheim International GmbH

US Patent


Assay Description
PI3Kalpha assay described herein provides IC50 values indicating the activity of the compounds inhibiting PI3 kinase alpha activity Inhibition of PI3...

US Patent US8618111 (2013)


BindingDB Entry DOI: 10.7270/Q2FX7838
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))		BDBM111618
PNG
(US8618111, B-5)
Show SMILES Cc1ncnc(N2CCN(CC2)C2CC2)c1C#Cc1ccc(N)nc1
Show InChI InChI=1S/C19H22N6/c1-14-17(6-2-15-3-7-18(20)21-12-15)19(23-13-22-14)25-10-8-24(9-11-25)16-4-5-16/h3,7,12-13,16H,4-5,8-11H2,1H3,(H2,20,21)
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n/an/a 58n/an/an/an/a7.50



Boehringer Ingelheim International GmbH

US Patent


Assay Description
PI3Kalpha assay described herein provides IC50 values indicating the activity of the compounds inhibiting PI3 kinase alpha activity Inhibition of PI3...

US Patent US8618111 (2013)


BindingDB Entry DOI: 10.7270/Q2FX7838
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))		BDBM111624
PNG
(US8618111, B-11)
Show SMILES CCc1ncnc(N2CCC(CC2)C(C)(C)O)c1C#Cc1ccc(N)nc1
Show InChI InChI=1S/C21H27N5O/c1-4-18-17(7-5-15-6-8-19(22)23-13-15)20(25-14-24-18)26-11-9-16(10-12-26)21(2,3)27/h6,8,13-14,16,27H,4,9-12H2,1-3H3,(H2,22,23)
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n/an/a 31n/an/an/an/a7.50



Boehringer Ingelheim International GmbH

US Patent


Assay Description
PI3Kalpha assay described herein provides IC50 values indicating the activity of the compounds inhibiting PI3 kinase alpha activity Inhibition of PI3...

US Patent US8618111 (2013)


BindingDB Entry DOI: 10.7270/Q2FX7838
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))		BDBM111628
PNG
(US8618111, B-15)
Show SMILES [#6]-[#6]-c1ncnc(-[#7]-2-[#6]-[#6]-[#6](-[#6]-[#6]-2)\[#6]=[#6](\[#6])-[#6])c1C#Cc1ccc(-[#7])nc1
Show InChI InChI=1S/C22H27N5/c1-4-20-19(7-5-18-6-8-21(23)24-14-18)22(26-15-25-20)27-11-9-17(10-12-27)13-16(2)3/h6,8,13-15,17H,4,9-12H2,1-3H3,(H2,23,24)
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n/an/a 622n/an/an/an/a7.50



Boehringer Ingelheim International GmbH

US Patent


Assay Description
PI3Kalpha assay described herein provides IC50 values indicating the activity of the compounds inhibiting PI3 kinase alpha activity Inhibition of PI3...

US Patent US8618111 (2013)


BindingDB Entry DOI: 10.7270/Q2FX7838
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))		BDBM111668
PNG
(US8618111, B-55)
Show SMILES CCc1ncnc(N2CCN(CCOC)CC2)c1C#Cc1ccc(N)nc1
Show InChI InChI=1S/C20H26N6O/c1-3-18-17(6-4-16-5-7-19(21)22-14-16)20(24-15-23-18)26-10-8-25(9-11-26)12-13-27-2/h5,7,14-15H,3,8-13H2,1-2H3,(H2,21,22)
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n/an/a 718n/an/an/an/a7.50



Boehringer Ingelheim International GmbH

US Patent


Assay Description
PI3Kalpha assay described herein provides IC50 values indicating the activity of the compounds inhibiting PI3 kinase alpha activity Inhibition of PI3...

US Patent US8618111 (2013)


BindingDB Entry DOI: 10.7270/Q2FX7838
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))		BDBM111684
PNG
(US8618111, B-71)
Show SMILES CCc1ncnc(N2CCCC(CO)C2)c1C#Cc1ccc(C)nc1
Show InChI InChI=1S/C20H24N4O/c1-3-19-18(9-8-16-7-6-15(2)21-11-16)20(23-14-22-19)24-10-4-5-17(12-24)13-25/h6-7,11,14,17,25H,3-5,10,12-13H2,1-2H3
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n/an/a 90n/an/an/an/a7.50



Boehringer Ingelheim International GmbH

US Patent


Assay Description
PI3Kalpha assay described herein provides IC50 values indicating the activity of the compounds inhibiting PI3 kinase alpha activity Inhibition of PI3...

US Patent US8618111 (2013)


BindingDB Entry DOI: 10.7270/Q2FX7838
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))		BDBM111699
PNG
(US8618111, B-86)
Show SMILES CCc1ncnc(N2CCC(CC2)OC)c1C#Cc1ccc(NC)nc1
Show InChI InChI=1S/C20H25N5O/c1-4-18-17(7-5-15-6-8-19(21-2)22-13-15)20(24-14-23-18)25-11-9-16(26-3)10-12-25/h6,8,13-14,16H,4,9-12H2,1-3H3,(H,21,22)
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n/an/a 94n/an/an/an/a7.50



Boehringer Ingelheim International GmbH

US Patent


Assay Description
PI3Kalpha assay described herein provides IC50 values indicating the activity of the compounds inhibiting PI3 kinase alpha activity Inhibition of PI3...

US Patent US8618111 (2013)


BindingDB Entry DOI: 10.7270/Q2FX7838
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))		BDBM111701
PNG
(US8618111, E-1)
Show SMILES CN(C)C(=O)CC1CCN(CC1)c1ncnc(C)c1C#Cc1ccc(N)nc1
Show InChI InChI=1S/C21H26N6O/c1-15-18(6-4-17-5-7-19(22)23-13-17)21(25-14-24-15)27-10-8-16(9-11-27)12-20(28)26(2)3/h5,7,13-14,16H,8-12H2,1-3H3,(H2,22,23)
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n/an/a 54n/an/an/an/a7.50



Boehringer Ingelheim International GmbH

US Patent


Assay Description
PI3Kalpha assay described herein provides IC50 values indicating the activity of the compounds inhibiting PI3 kinase alpha activity Inhibition of PI3...

US Patent US8618111 (2013)


BindingDB Entry DOI: 10.7270/Q2FX7838
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))		BDBM111705
PNG
(US8618111, E-5)
Show SMILES CCNC(=O)CC1CCN(CC1)c1ncnc(C)c1C#Cc1ccc(N)nc1
Show InChI InChI=1S/C21H26N6O/c1-3-23-20(28)12-16-8-10-27(11-9-16)21-18(15(2)25-14-26-21)6-4-17-5-7-19(22)24-13-17/h5,7,13-14,16H,3,8-12H2,1-2H3,(H2,22,24)(H,23,28)
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n/an/a 38n/an/an/an/a7.50



Boehringer Ingelheim International GmbH

US Patent


Assay Description
PI3Kalpha assay described herein provides IC50 values indicating the activity of the compounds inhibiting PI3 kinase alpha activity Inhibition of PI3...

US Patent US8618111 (2013)


BindingDB Entry DOI: 10.7270/Q2FX7838
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))		BDBM111714
PNG
(US8618111, F-6)
Show SMILES Cc1ncnc(N2CCC(CNC(=O)C3CCCCC3)CC2)c1C#Cc1ccc(N)nc1
Show InChI InChI=1S/C25H32N6O/c1-18-22(9-7-19-8-10-23(26)27-15-19)24(30-17-29-18)31-13-11-20(12-14-31)16-28-25(32)21-5-3-2-4-6-21/h8,10,15,17,20-21H,2-6,11-14,16H2,1H3,(H2,26,27)(H,28,32)
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n/an/a 51n/an/an/an/a7.50



Boehringer Ingelheim International GmbH

US Patent


Assay Description
PI3Kalpha assay described herein provides IC50 values indicating the activity of the compounds inhibiting PI3 kinase alpha activity Inhibition of PI3...

US Patent US8618111 (2013)


BindingDB Entry DOI: 10.7270/Q2FX7838
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))		BDBM111733
PNG
(US8618111, H-5)
Show SMILES CCc1ncnc(N2CCN(CC2)C(C)C)c1C#Cc1ccc(N)nc1
Show InChI InChI=1S/C20H26N6/c1-4-18-17(7-5-16-6-8-19(21)22-13-16)20(24-14-23-18)26-11-9-25(10-12-26)15(2)3/h6,8,13-15H,4,9-12H2,1-3H3,(H2,21,22)
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n/an/a 745n/an/an/an/a7.50



Boehringer Ingelheim International GmbH

US Patent


Assay Description
PI3Kalpha assay described herein provides IC50 values indicating the activity of the compounds inhibiting PI3 kinase alpha activity Inhibition of PI3...

US Patent US8618111 (2013)


BindingDB Entry DOI: 10.7270/Q2FX7838
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))		BDBM111680
PNG
(US8618111, B-67)
Show SMILES CC1CN(CCC1O)c1ncnc(C)c1C#Cc1ccc(N)nc1
Show InChI InChI=1S/C18H21N5O/c1-12-10-23(8-7-16(12)24)18-15(13(2)21-11-22-18)5-3-14-4-6-17(19)20-9-14/h4,6,9,11-12,16,24H,7-8,10H2,1-2H3,(H2,19,20)
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n/an/a 90n/an/an/an/a7.50



Boehringer Ingelheim International GmbH

US Patent


Assay Description
PI3Kalpha assay described herein provides IC50 values indicating the activity of the compounds inhibiting PI3 kinase alpha activity Inhibition of PI3...

US Patent US8618111 (2013)


BindingDB Entry DOI: 10.7270/Q2FX7838
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))		BDBM111737
PNG
(US8618111, H-9)
Show SMILES CCc1ncnc(N2CCN(CC2)C2CCN(C)CC2)c1C#Cc1ccc(N)nc1
Show InChI InChI=1S/C23H31N7/c1-3-21-20(6-4-18-5-7-22(24)25-16-18)23(27-17-26-21)30-14-12-29(13-15-30)19-8-10-28(2)11-9-19/h5,7,16-17,19H,3,8-15H2,1-2H3,(H2,24,25)
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n/an/a 449n/an/an/an/a7.50



Boehringer Ingelheim International GmbH

US Patent


Assay Description
PI3Kalpha assay described herein provides IC50 values indicating the activity of the compounds inhibiting PI3 kinase alpha activity Inhibition of PI3...

US Patent US8618111 (2013)


BindingDB Entry DOI: 10.7270/Q2FX7838
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))		BDBM111614
PNG
(US8618111, B-1)
Show SMILES Cc1ncnc(N2CCOC(C)(C)C2)c1C#Cc1ccc(N)nc1
Show InChI InChI=1S/C18H21N5O/c1-13-15(6-4-14-5-7-16(19)20-10-14)17(22-12-21-13)23-8-9-24-18(2,3)11-23/h5,7,10,12H,8-9,11H2,1-3H3,(H2,19,20)
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n/an/a 46n/an/an/an/a7.50



Boehringer Ingelheim International GmbH

US Patent


Assay Description
PI3Kalpha assay described herein provides IC50 values indicating the activity of the compounds inhibiting PI3 kinase alpha activity Inhibition of PI3...

US Patent US8618111 (2013)


BindingDB Entry DOI: 10.7270/Q2FX7838
More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%