Affinity Data by Patent

Patent code US9339486

Found 15 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Cannabinoid receptor 2 (Homo sapiens (Human))	BDBM227552 (US9339486, CP55,940) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid PDB UniChem	PDB US Patent	1.80	n/a	n/a	n/a	n/a	n/a	n/a	7.4	n/a
The Cleveland Clinic Foundation US Patent					Assay Description Cell membrane homogenates (15 μg protein) were incubated for 120 min at 37� C. with 0.8 nM [3H]WIN 55212-2 (the reference standard [Munro, 1993 ...				US Patent US9339486 (2016) BindingDB Entry DOI: 10.7270/Q2DN43W9
The Cleveland Clinic Foundation US Patent					More data for this Ligand-Target Pair				3D Structure (crystal)
Cannabinoid receptor 1 (Homo sapiens (Human))	BDBM227552 (US9339486, CP55,940) Show SMILES Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid PDB UniChem	PDB US Patent	3.40	n/a	n/a	n/a	n/a	n/a	n/a	7.4	n/a
The Cleveland Clinic Foundation US Patent					Assay Description Cell membrane homogenates (25 μg protein) were incubated for 120 min at 37� C. with 0.5 nM [3H]CP 55940 (the reference standard [Rinaldi-Carmona...				US Patent US9339486 (2016) BindingDB Entry DOI: 10.7270/Q2DN43W9
The Cleveland Clinic Foundation US Patent					More data for this Ligand-Target Pair				3D Structure (crystal)
Cannabinoid receptor 2 (Homo sapiens (Human))	BDBM50335938 ((3-benzyl-3-methyl-2,3-dihydrobenzofuran-6-yl)(pip...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	US Patent	422	n/a	n/a	n/a	n/a	n/a	n/a	7.4	n/a
The Cleveland Clinic Foundation US Patent					Assay Description Cell membrane homogenates (15 μg protein) were incubated for 120 min at 37� C. with 0.8 nM [3H]WIN 55212-2 (the reference standard [Munro, 1993 ...				US Patent US9339486 (2016) BindingDB Entry DOI: 10.7270/Q2DN43W9
The Cleveland Clinic Foundation US Patent					More data for this Ligand-Target Pair
Cannabinoid receptor 1 (Homo sapiens (Human))	BDBM50335938 ((3-benzyl-3-methyl-2,3-dihydrobenzofuran-6-yl)(pip...) Show SMILES Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	US Patent	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	7.4	n/a
The Cleveland Clinic Foundation US Patent					Assay Description Cell membrane homogenates (25 μg protein) were incubated for 120 min at 37� C. with 0.5 nM [3H]CP 55940 (the reference standard [Rinaldi-Carmona...				US Patent US9339486 (2016) BindingDB Entry DOI: 10.7270/Q2DN43W9
The Cleveland Clinic Foundation US Patent					More data for this Ligand-Target Pair
Cannabinoid receptor 2 (Homo sapiens (Human))	BDBM227550 (US9339486, 2) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	479	n/a	n/a	n/a	n/a
The Cleveland Clinic Foundation US Patent					Assay Description Functional activity was evaluated using GTPγ[35S] assay in CHO membrane extracts expressing recombinant hCB1 (human CB1) receptors or hCB2 (huma...				US Patent US9339486 (2016) BindingDB Entry DOI: 10.7270/Q2DN43W9
The Cleveland Clinic Foundation US Patent					More data for this Ligand-Target Pair
Cannabinoid receptor 1 (Homo sapiens (Human))	BDBM50335938 ((3-benzyl-3-methyl-2,3-dihydrobenzofuran-6-yl)(pip...) Show SMILES Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	US Patent	n/a	n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a
The Cleveland Clinic Foundation US Patent					Assay Description Functional activity was evaluated using GTPγ[35S] assay in CHO membrane extracts expressing recombinant hCB1 (human CB1) receptors or hCB2 (huma...				US Patent US9339486 (2016) BindingDB Entry DOI: 10.7270/Q2DN43W9
The Cleveland Clinic Foundation US Patent					More data for this Ligand-Target Pair
Cannabinoid receptor 2 (Homo sapiens (Human))	BDBM50335938 ((3-benzyl-3-methyl-2,3-dihydrobenzofuran-6-yl)(pip...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	US Patent	n/a	n/a	n/a	n/a	160	n/a	n/a	n/a	n/a
The Cleveland Clinic Foundation US Patent					Assay Description Functional activity was evaluated using GTPγ[35S] assay in CHO membrane extracts expressing recombinant hCB1 (human CB1) receptors or hCB2 (huma...				US Patent US9339486 (2016) BindingDB Entry DOI: 10.7270/Q2DN43W9
The Cleveland Clinic Foundation US Patent					More data for this Ligand-Target Pair
Cannabinoid receptor 2 (Homo sapiens (Human))	BDBM227551 (US9339486, 5) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	409	n/a	n/a	n/a	n/a
The Cleveland Clinic Foundation US Patent					Assay Description Functional activity was evaluated using GTPγ[35S] assay in CHO membrane extracts expressing recombinant hCB1 (human CB1) receptors or hCB2 (huma...				US Patent US9339486 (2016) BindingDB Entry DOI: 10.7270/Q2DN43W9
The Cleveland Clinic Foundation US Patent					More data for this Ligand-Target Pair
Cannabinoid receptor 1 (Rattus norvegicus (rat))	BDBM227552 (US9339486, CP55,940) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase PC cid PC sid PDB UniChem	PDB US Patent	n/a	n/a	n/a	n/a	0.140	n/a	n/a	n/a	n/a
The Cleveland Clinic Foundation US Patent					Assay Description The compound of Example 3 was tested for agonist activity at the rat CB1 (rCB1) and rCB2 receptors, at eight concentrations, in duplicate: 10, 3, 1, ...				US Patent US9339486 (2016) BindingDB Entry DOI: 10.7270/Q2DN43W9
The Cleveland Clinic Foundation US Patent					More data for this Ligand-Target Pair				3D Structure (crystal)
Cannabinoid receptor 2 (Rattus norvegicus (Rat))	BDBM50335938 ((3-benzyl-3-methyl-2,3-dihydrobenzofuran-6-yl)(pip...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	US Patent	n/a	n/a	n/a	n/a	21.7	n/a	n/a	n/a	n/a
The Cleveland Clinic Foundation US Patent					Assay Description The compound of Example 3 was tested for agonist activity at the rat CB1 (rCB1) and rCB2 receptors, at eight concentrations, in duplicate: 10, 3, 1, ...				US Patent US9339486 (2016) BindingDB Entry DOI: 10.7270/Q2DN43W9
The Cleveland Clinic Foundation US Patent					More data for this Ligand-Target Pair
Cannabinoid receptor 2 (Homo sapiens (Human))	BDBM50335938 ((3-benzyl-3-methyl-2,3-dihydrobenzofuran-6-yl)(pip...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	US Patent	n/a	n/a	n/a	n/a	128	n/a	n/a	n/a	n/a
The Cleveland Clinic Foundation US Patent					Assay Description Functional activity was evaluated using GTPγ[35S] assay in CHO membrane extracts expressing recombinant hCB1 (human CB1) receptors or hCB2 (huma...				US Patent US9339486 (2016) BindingDB Entry DOI: 10.7270/Q2DN43W9
The Cleveland Clinic Foundation US Patent					More data for this Ligand-Target Pair
Cannabinoid receptor 1 (Rattus norvegicus (rat))	BDBM50335938 ((3-benzyl-3-methyl-2,3-dihydrobenzofuran-6-yl)(pip...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	US Patent	n/a	n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a
The Cleveland Clinic Foundation US Patent					Assay Description The compound of Example 3 was tested for agonist activity at the rat CB1 (rCB1) and rCB2 receptors, at eight concentrations, in duplicate: 10, 3, 1, ...				US Patent US9339486 (2016) BindingDB Entry DOI: 10.7270/Q2DN43W9
The Cleveland Clinic Foundation US Patent					More data for this Ligand-Target Pair
Cannabinoid receptor 2 (Rattus norvegicus (Rat))	BDBM227552 (US9339486, CP55,940) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase PC cid PC sid PDB UniChem	US Patent	n/a	n/a	n/a	n/a	1.13	n/a	n/a	n/a	n/a
The Cleveland Clinic Foundation US Patent					Assay Description The compound of Example 3 was tested for agonist activity at the rat CB1 (rCB1) and rCB2 receptors, at eight concentrations, in duplicate: 10, 3, 1, ...				US Patent US9339486 (2016) BindingDB Entry DOI: 10.7270/Q2DN43W9
The Cleveland Clinic Foundation US Patent					More data for this Ligand-Target Pair
Cannabinoid receptor 1 (Homo sapiens (Human))	BDBM227552 (US9339486, CP55,940) Show SMILES Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid PDB UniChem	PDB US Patent	n/a	n/a	n/a	n/a	9	n/a	n/a	n/a	n/a
The Cleveland Clinic Foundation US Patent					Assay Description Functional activity was evaluated using GTPγ[35S] assay in CHO membrane extracts expressing recombinant hCB1 (human CB1) receptors or hCB2 (huma...				US Patent US9339486 (2016) BindingDB Entry DOI: 10.7270/Q2DN43W9
The Cleveland Clinic Foundation US Patent					More data for this Ligand-Target Pair				3D Structure (crystal)
Cannabinoid receptor 2 (Homo sapiens (Human))	BDBM227552 (US9339486, CP55,940) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid PDB UniChem	PDB US Patent	n/a	n/a	n/a	n/a	6.5	n/a	n/a	n/a	n/a
The Cleveland Clinic Foundation US Patent					Assay Description Functional activity was evaluated using GTPγ[35S] assay in CHO membrane extracts expressing recombinant hCB1 (human CB1) receptors or hCB2 (huma...				US Patent US9339486 (2016) BindingDB Entry DOI: 10.7270/Q2DN43W9
The Cleveland Clinic Foundation US Patent					More data for this Ligand-Target Pair				3D Structure (crystal)

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* indicates data uncertainty>20%