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Patent code US9346798

Compile Data Set for Download or QSAR

Found 678 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))		BDBM231508
PNG
(US9346798, 259)
Show SMILES CCc1ccccc1N1CCOc2cc(ccc12)S(=O)(=O)Nc1nccs1
Show InChI InChI=1S/C19H19N3O3S2/c1-2-14-5-3-4-6-16(14)22-10-11-25-18-13-15(7-8-17(18)22)27(23,24)21-19-20-9-12-26-19/h3-9,12-13H,2,10-11H2,1H3,(H,20,21)
PDB

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US Patent
n/an/a 1.60E+3n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...

US Patent US9346798 (2016)


BindingDB Entry DOI: 10.7270/Q24X56N2
More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))		BDBM231272
PNG
(US9346798, 19)
Show SMILES CN1CCN(c2ccc(cc2Cl)C(F)(F)F)c2ccc(cc12)S(=O)(=O)Nc1ncns1
Show InChI InChI=1S/C18H15ClF3N5O2S2/c1-26-6-7-27(14-4-2-11(8-13(14)19)18(20,21)22)15-5-3-12(9-16(15)26)31(28,29)25-17-23-10-24-30-17/h2-5,8-10H,6-7H2,1H3,(H,23,24,25)
PDB

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US Patent
n/an/a>1.00E+4n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with either Nav 1.7 or with Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro auto...

US Patent US9346798 (2016)


BindingDB Entry DOI: 10.7270/Q24X56N2
More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))		BDBM231276
PNG
(US9346798, 23)
Show SMILES FC(F)(F)c1ccc(N2CCOc3cc(ccc23)S(=O)(=O)Nc2ncns2)c(c1)-c1cncnc1
Show InChI InChI=1S/C21H15F3N6O3S2/c22-21(23,24)14-1-3-17(16(7-14)13-9-25-11-26-10-13)30-5-6-33-19-8-15(2-4-18(19)30)35(31,32)29-20-27-12-28-34-20/h1-4,7-12H,5-6H2,(H,27,28,29)
PDB

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US Patent
n/an/a 5.41E+3n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with either Nav 1.7 or with Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro auto...

US Patent US9346798 (2016)


BindingDB Entry DOI: 10.7270/Q24X56N2
More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))		BDBM231277
PNG
(US9346798, 24)
Show SMILES FC(F)(F)c1ccc(N2CCOc3cc(ccc23)S(=O)(=O)Nc2ncco2)c(Cl)c1
Show InChI InChI=1S/C18H13ClF3N3O4S/c19-13-9-11(18(20,21)22)1-3-14(13)25-6-8-28-16-10-12(2-4-15(16)25)30(26,27)24-17-23-5-7-29-17/h1-5,7,9-10H,6,8H2,(H,23,24)
PDB

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n/an/a>1.00E+4n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with either Nav 1.7 or with Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro auto...

US Patent US9346798 (2016)


BindingDB Entry DOI: 10.7270/Q24X56N2
More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))		BDBM231283
PNG
(US9346798, 30)
Show SMILES O=S(=O)(Nc1ncns1)c1ccc2N(CCOc2c1)c1ccccc1
Show InChI InChI=1S/C16H14N4O3S2/c21-25(22,19-16-17-11-18-24-16)13-6-7-14-15(10-13)23-9-8-20(14)12-4-2-1-3-5-12/h1-7,10-11H,8-9H2,(H,17,18,19)
PDB

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US Patent
n/an/a>1.00E+4n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with either Nav 1.7 or with Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro auto...

US Patent US9346798 (2016)


BindingDB Entry DOI: 10.7270/Q24X56N2
More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))		BDBM231288
PNG
(US9346798, 35)
Show SMILES FC(F)(F)Oc1cccc(c1)N1CCOc2cc(ccc12)S(=O)(=O)Nc1ncns1
Show InChI InChI=1S/C17H13F3N4O4S2/c18-17(19,20)28-12-3-1-2-11(8-12)24-6-7-27-15-9-13(4-5-14(15)24)30(25,26)23-16-21-10-22-29-16/h1-5,8-10H,6-7H2,(H,21,22,23)
PDB

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n/an/a>1.00E+4n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with either Nav 1.7 or with Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro auto...

US Patent US9346798 (2016)


BindingDB Entry DOI: 10.7270/Q24X56N2
More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))		BDBM231293
PNG
(US9346798, 40)
Show SMILES Clc1ccc(cc1)N1CCOc2cc(ccc12)S(=O)(=O)Nc1nccs1
Show InChI InChI=1S/C17H14ClN3O3S2/c18-12-1-3-13(4-2-12)21-8-9-24-16-11-14(5-6-15(16)21)26(22,23)20-17-19-7-10-25-17/h1-7,10-11H,8-9H2,(H,19,20)
PDB

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n/an/a>1.00E+4n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with either Nav 1.7 or with Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro auto...

US Patent US9346798 (2016)


BindingDB Entry DOI: 10.7270/Q24X56N2
More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))		BDBM231299
PNG
(US9346798, 46)
Show SMILES Clc1ccccc1N1CCOc2cc(ccc12)S(=O)(=O)Nc1nccs1
Show InChI InChI=1S/C17H14ClN3O3S2/c18-13-3-1-2-4-14(13)21-8-9-24-16-11-12(5-6-15(16)21)26(22,23)20-17-19-7-10-25-17/h1-7,10-11H,8-9H2,(H,19,20)
PDB

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n/an/a>1.00E+4n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with either Nav 1.7 or with Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro auto...

US Patent US9346798 (2016)


BindingDB Entry DOI: 10.7270/Q24X56N2
More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))		BDBM231320
PNG
(US9346798, 67)
Show SMILES Cc1ccc(Cl)c(c1)N1CCOc2cc(ccc12)S(=O)(=O)Nc1nccs1
Show InChI InChI=1S/C18H16ClN3O3S2/c1-12-2-4-14(19)16(10-12)22-7-8-25-17-11-13(3-5-15(17)22)27(23,24)21-18-20-6-9-26-18/h2-6,9-11H,7-8H2,1H3,(H,20,21)
PDB

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US Patent
n/an/a 5.33E+3n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with either Nav 1.7 or with Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro auto...

US Patent US9346798 (2016)


BindingDB Entry DOI: 10.7270/Q24X56N2
More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))		BDBM231342
PNG
(US9346798, 89)
Show SMILES FC(F)(F)c1ccc(N2CCOc3cc(ccc23)S(=O)(=O)Nc2ccncn2)c(c1)C#N
Show InChI InChI=1S/C20H14F3N5O3S/c21-20(22,23)14-1-3-16(13(9-14)11-24)28-7-8-31-18-10-15(2-4-17(18)28)32(29,30)27-19-5-6-25-12-26-19/h1-6,9-10,12H,7-8H2,(H,25,26,27)
PDB

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n/an/a 1.14E+3n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with either Nav 1.7 or with Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro auto...

US Patent US9346798 (2016)


BindingDB Entry DOI: 10.7270/Q24X56N2
More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))		BDBM231360
PNG
(US9346798, 107)
Show SMILES COc1cc(ccc1N1C[C@H](C)Oc2cc(ccc12)S(=O)(=O)Nc1nccs1)C#N |r|
Show InChI InChI=1S/C20H18N4O4S2/c1-13-12-24(16-5-3-14(11-21)9-18(16)27-2)17-6-4-15(10-19(17)28-13)30(25,26)23-20-22-7-8-29-20/h3-10,13H,12H2,1-2H3,(H,22,23)/t13-/m0/s1
PDB

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n/an/a>1.00E+4n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with either Nav 1.7 or with Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro auto...

US Patent US9346798 (2016)


BindingDB Entry DOI: 10.7270/Q24X56N2
More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))		BDBM231365
PNG
(US9346798, 112)
Show SMILES CC(C)c1ccc(cc1)N1CCOc2cc(ccc12)S(=O)(=O)Nc1nccs1
Show InChI InChI=1S/C20H21N3O3S2/c1-14(2)15-3-5-16(6-4-15)23-10-11-26-19-13-17(7-8-18(19)23)28(24,25)22-20-21-9-12-27-20/h3-9,12-14H,10-11H2,1-2H3,(H,21,22)
PDB

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n/an/a>1.00E+4n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with either Nav 1.7 or with Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro auto...

US Patent US9346798 (2016)


BindingDB Entry DOI: 10.7270/Q24X56N2
More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))		BDBM231366
PNG
(US9346798, 113)
Show SMILES FC(F)(F)COc1ccc(cc1)N1CCOc2cc(ccc12)S(=O)(=O)Nc1nccs1
Show InChI InChI=1S/C19H16F3N3O4S2/c20-19(21,22)12-29-14-3-1-13(2-4-14)25-8-9-28-17-11-15(5-6-16(17)25)31(26,27)24-18-23-7-10-30-18/h1-7,10-11H,8-9,12H2,(H,23,24)
PDB

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n/an/a 3.37E+3n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with either Nav 1.7 or with Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro auto...

US Patent US9346798 (2016)


BindingDB Entry DOI: 10.7270/Q24X56N2
More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))		BDBM231372
PNG
(US9346798, 119)
Show SMILES COc1ccc(cc1OC)N1CCOc2cc(ccc12)S(=O)(=O)Nc1nccs1
Show InChI InChI=1S/C19H19N3O5S2/c1-25-16-6-3-13(11-18(16)26-2)22-8-9-27-17-12-14(4-5-15(17)22)29(23,24)21-19-20-7-10-28-19/h3-7,10-12H,8-9H2,1-2H3,(H,20,21)
PDB

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n/an/a>1.00E+4n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with either Nav 1.7 or with Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro auto...

US Patent US9346798 (2016)


BindingDB Entry DOI: 10.7270/Q24X56N2
More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))		BDBM231378
PNG
(US9346798, 125)
Show SMILES FC(F)(F)c1cc(ccc1Cl)N1CCOc2cc(ccc12)S(=O)(=O)Nc1nccs1
Show InChI InChI=1S/C18H13ClF3N3O3S2/c19-14-3-1-11(9-13(14)18(20,21)22)25-6-7-28-16-10-12(2-4-15(16)25)30(26,27)24-17-23-5-8-29-17/h1-5,8-10H,6-7H2,(H,23,24)
PDB

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n/an/a 6.55E+3n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with either Nav 1.7 or with Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro auto...

US Patent US9346798 (2016)


BindingDB Entry DOI: 10.7270/Q24X56N2
More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))		BDBM231380
PNG
(US9346798, 127)
Show SMILES FC1(F)Oc2ccc(cc2O1)N1CCOc2cc(ccc12)S(=O)(=O)Nc1nccs1
Show InChI InChI=1S/C18H13F2N3O5S2/c19-18(20)27-14-4-1-11(9-16(14)28-18)23-6-7-26-15-10-12(2-3-13(15)23)30(24,25)22-17-21-5-8-29-17/h1-5,8-10H,6-7H2,(H,21,22)
PDB

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n/an/a>1.00E+4n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with either Nav 1.7 or with Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro auto...

US Patent US9346798 (2016)


BindingDB Entry DOI: 10.7270/Q24X56N2
More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))		BDBM231384
PNG
(US9346798, 131)
Show SMILES COc1cncc(c1)N1CCOc2cc(ccc12)S(=O)(=O)Nc1nccs1
Show InChI InChI=1S/C17H16N4O4S2/c1-24-13-8-12(10-18-11-13)21-5-6-25-16-9-14(2-3-15(16)21)27(22,23)20-17-19-4-7-26-17/h2-4,7-11H,5-6H2,1H3,(H,19,20)
PDB

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AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with either Nav 1.7 or with Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro auto...

US Patent US9346798 (2016)


BindingDB Entry DOI: 10.7270/Q24X56N2
More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))		BDBM231393
PNG
(US9346798, 140)
Show SMILES Cc1cc(OC(F)(F)F)ccc1N1CCOc2cc(ccc12)S(=O)(=O)Nc1nccs1
Show InChI InChI=1S/C19H16F3N3O4S2/c1-12-10-13(29-19(20,21)22)2-4-15(12)25-7-8-28-17-11-14(3-5-16(17)25)31(26,27)24-18-23-6-9-30-18/h2-6,9-11H,7-8H2,1H3,(H,23,24)
PDB

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n/an/a 6.60E+3n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with either Nav 1.7 or with Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro auto...

US Patent US9346798 (2016)


BindingDB Entry DOI: 10.7270/Q24X56N2
More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))		BDBM231410
PNG
(US9346798, 157)
Show SMILES FC(F)(F)c1ccccc1N1CCOc2cc(ccc12)S(=O)(=O)Nc1nccs1
Show InChI InChI=1S/C18H14F3N3O3S2/c19-18(20,21)13-3-1-2-4-14(13)24-8-9-27-16-11-12(5-6-15(16)24)29(25,26)23-17-22-7-10-28-17/h1-7,10-11H,8-9H2,(H,22,23)
PDB

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n/an/a>1.00E+4n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with either Nav 1.7 or with Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro auto...

US Patent US9346798 (2016)


BindingDB Entry DOI: 10.7270/Q24X56N2
More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))		BDBM231423
PNG
(US9346798, 170)
Show SMILES Fc1cc(Cl)ccc1N1CCOc2cc(ccc12)S(=O)(=O)Nc1nccs1
Show InChI InChI=1S/C17H13ClFN3O3S2/c18-11-1-3-14(13(19)9-11)22-6-7-25-16-10-12(2-4-15(16)22)27(23,24)21-17-20-5-8-26-17/h1-5,8-10H,6-7H2,(H,20,21)
PDB

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UniProtKB/SwissProt

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n/an/a>1.00E+4n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with either Nav 1.7 or with Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro auto...

US Patent US9346798 (2016)


BindingDB Entry DOI: 10.7270/Q24X56N2
More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))		BDBM231426
PNG
(US9346798, 173)
Show SMILES FC(F)(F)c1cccc(c1)N1CCOc2cc(ccc12)S(=O)(=O)Nc1nccs1
Show InChI InChI=1S/C18H14F3N3O3S2/c19-18(20,21)12-2-1-3-13(10-12)24-7-8-27-16-11-14(4-5-15(16)24)29(25,26)23-17-22-6-9-28-17/h1-6,9-11H,7-8H2,(H,22,23)
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n/an/a>1.00E+4n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with either Nav 1.7 or with Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro auto...

US Patent US9346798 (2016)


BindingDB Entry DOI: 10.7270/Q24X56N2
More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))		BDBM231450
PNG
(US9346798, 197)
Show SMILES [O-][N+](=O)c1ccc(OC(=O)N2CCOc3cc(ccc23)S(=O)(=O)Nc2nccs2)cc1
Show InChI InChI=1S/C18H14N4O7S2/c23-18(29-13-3-1-12(2-4-13)22(24)25)21-8-9-28-16-11-14(5-6-15(16)21)31(26,27)20-17-19-7-10-30-17/h1-7,10-11H,8-9H2,(H,19,20)
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n/an/a>1.00E+4n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with either Nav 1.7 or with Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro auto...

US Patent US9346798 (2016)


BindingDB Entry DOI: 10.7270/Q24X56N2
More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))		BDBM231452
PNG
(US9346798, 199)
Show SMILES Fc1ccc(cc1)-c1ccc(N2CCOc3cc(ccc23)S(=O)(=O)Nc2nccs2)c(c1)C#N
Show InChI InChI=1S/C24H17FN4O3S2/c25-19-4-1-16(2-5-19)17-3-7-21(18(13-17)15-26)29-10-11-32-23-14-20(6-8-22(23)29)34(30,31)28-24-27-9-12-33-24/h1-9,12-14H,10-11H2,(H,27,28)
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n/an/a 1.22E+3n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with either Nav 1.7 or with Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro auto...

US Patent US9346798 (2016)


BindingDB Entry DOI: 10.7270/Q24X56N2
More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))		BDBM231460
PNG
(US9346798, 207)
Show SMILES OCC(O)Cc1cc(ccc1N1CCOc2cc(ccc12)S(=O)(=O)Nc1nccs1)C(F)(F)F
Show InChI InChI=1S/C21H20F3N3O5S2/c22-21(23,24)14-1-3-17(13(9-14)10-15(29)12-28)27-6-7-32-19-11-16(2-4-18(19)27)34(30,31)26-20-25-5-8-33-20/h1-5,8-9,11,15,28-29H,6-7,10,12H2,(H,25,26)
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n/an/a 3.11E+3n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with either Nav 1.7 or with Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro auto...

US Patent US9346798 (2016)


BindingDB Entry DOI: 10.7270/Q24X56N2
More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))		BDBM231462
PNG
(US9346798, 209)
Show SMILES OC[C@H](O)Cc1cc(ccc1N1CCOc2cc(ccc12)S(=O)(=O)Nc1nccs1)C(F)(F)F |r|
Show InChI InChI=1S/C21H20F3N3O5S2/c22-21(23,24)14-1-3-17(13(9-14)10-15(29)12-28)27-6-7-32-19-11-16(2-4-18(19)27)34(30,31)26-20-25-5-8-33-20/h1-5,8-9,11,15,28-29H,6-7,10,12H2,(H,25,26)/t15-/m1/s1
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n/an/a 497n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with either Nav 1.7 or with Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro auto...

US Patent US9346798 (2016)


BindingDB Entry DOI: 10.7270/Q24X56N2
More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))		BDBM231478
PNG
(US9346798, 226)
Show SMILES Cc1cc(ccc1N1CCOc2cc(ccc12)S(=O)(=O)Nc1nccs1)C#N
Show InChI InChI=1S/C19H16N4O3S2/c1-13-10-14(12-20)2-4-16(13)23-7-8-26-18-11-15(3-5-17(18)23)28(24,25)22-19-21-6-9-27-19/h2-6,9-11H,7-8H2,1H3,(H,21,22)
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n/an/a>1.00E+4n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with either Nav 1.7 or with Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro auto...

US Patent US9346798 (2016)


BindingDB Entry DOI: 10.7270/Q24X56N2
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))		BDBM231257
PNG
(US9346798, 4)
Show SMILES FC(F)(F)c1ccc(N2CCOc3cc(ccc23)S(=O)(=O)Nc2ncns2)c(c1)-c1cn[nH]c1
Show InChI InChI=1S/C20H15F3N6O3S2/c21-20(22,23)13-1-3-16(15(7-13)12-9-25-26-10-12)29-5-6-32-18-8-14(2-4-17(18)29)34(30,31)28-19-24-11-27-33-19/h1-4,7-11H,5-6H2,(H,25,26)(H,24,27,28)
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n/an/a 9.33n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with either Nav 1.7 or with Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro auto...

US Patent US9346798 (2016)


BindingDB Entry DOI: 10.7270/Q24X56N2
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))		BDBM231261
PNG
(US9346798, 8)
Show SMILES NCc1nsc(NS(=O)(=O)c2ccc3N(CCOc3c2)c2ccc(cc2Cl)C(F)(F)F)n1
Show InChI InChI=1S/C18H15ClF3N5O3S2/c19-12-7-10(18(20,21)22)1-3-13(12)27-5-6-30-15-8-11(2-4-14(15)27)32(28,29)26-17-24-16(9-23)25-31-17/h1-4,7-8H,5-6,9,23H2,(H,24,25,26)
PDB

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n/an/a 7.58E+3n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with either Nav 1.7 or with Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro auto...

US Patent US9346798 (2016)


BindingDB Entry DOI: 10.7270/Q24X56N2
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))		BDBM231264
PNG
(US9346798, 11)
Show SMILES FC(F)(F)c1ccc(N2CCOc3cc(ccc23)S(=O)(=O)Nc2cscn2)c(Cl)c1
Show InChI InChI=1S/C18H13ClF3N3O3S2/c19-13-7-11(18(20,21)22)1-3-14(13)25-5-6-28-16-8-12(2-4-15(16)25)30(26,27)24-17-9-29-10-23-17/h1-4,7-10,24H,5-6H2
PDB

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n/an/a 3.21E+3n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with either Nav 1.7 or with Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro auto...

US Patent US9346798 (2016)


BindingDB Entry DOI: 10.7270/Q24X56N2
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))		BDBM231274
PNG
(US9346798, 21)
Show SMILES FC(F)(F)c1ccc(N2CCOc3cc(ccc23)S(=O)(=O)Nc2ncns2)c(c1)-c1cccnc1
Show InChI InChI=1S/C22H16F3N5O3S2/c23-22(24,25)15-3-5-18(17(10-15)14-2-1-7-26-12-14)30-8-9-33-20-11-16(4-6-19(20)30)35(31,32)29-21-27-13-28-34-21/h1-7,10-13H,8-9H2,(H,27,28,29)
PDB

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n/an/a 15.8n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with either Nav 1.7 or with Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro auto...

US Patent US9346798 (2016)


BindingDB Entry DOI: 10.7270/Q24X56N2
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))		BDBM231278
PNG
(US9346798, 25)
Show SMILES FC(F)(F)c1ccc(N2CCOc3cc(ccc23)S(=O)(=O)Nc2ncns2)c(c1)C1=CCOCC1 |t:33|
Show InChI InChI=1S/C22H19F3N4O4S2/c23-22(24,25)15-1-3-18(17(11-15)14-5-8-32-9-6-14)29-7-10-33-20-12-16(2-4-19(20)29)35(30,31)28-21-26-13-27-34-21/h1-5,11-13H,6-10H2,(H,26,27,28)
PDB

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n/an/a 12.3n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with either Nav 1.7 or with Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro auto...

US Patent US9346798 (2016)


BindingDB Entry DOI: 10.7270/Q24X56N2
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))		BDBM231283
PNG
(US9346798, 30)
Show SMILES O=S(=O)(Nc1ncns1)c1ccc2N(CCOc2c1)c1ccccc1
Show InChI InChI=1S/C16H14N4O3S2/c21-25(22,19-16-17-11-18-24-16)13-6-7-14-15(10-13)23-9-8-20(14)12-4-2-1-3-5-12/h1-7,10-11H,8-9H2,(H,17,18,19)
PDB

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n/an/a 142n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with either Nav 1.7 or with Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro auto...

US Patent US9346798 (2016)


BindingDB Entry DOI: 10.7270/Q24X56N2
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))		BDBM231288
PNG
(US9346798, 35)
Show SMILES FC(F)(F)Oc1cccc(c1)N1CCOc2cc(ccc12)S(=O)(=O)Nc1ncns1
Show InChI InChI=1S/C17H13F3N4O4S2/c18-17(19,20)28-12-3-1-2-11(8-12)24-6-7-27-15-9-13(4-5-14(15)24)30(25,26)23-16-21-10-22-29-16/h1-5,8-10H,6-7H2,(H,21,22,23)
PDB

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n/an/a 43.5n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with either Nav 1.7 or with Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro auto...

US Patent US9346798 (2016)


BindingDB Entry DOI: 10.7270/Q24X56N2
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))		BDBM231304
PNG
(US9346798, 51)
Show SMILES CN1CCC(=CC1)c1cc(ccc1N1CCOc2cc(ccc12)S(=O)(=O)Nc1ccncn1)C(F)(F)F |c:4|
Show InChI InChI=1S/C25H24F3N5O3S/c1-32-10-7-17(8-11-32)20-14-18(25(26,27)28)2-4-21(20)33-12-13-36-23-15-19(3-5-22(23)33)37(34,35)31-24-6-9-29-16-30-24/h2-7,9,14-16H,8,10-13H2,1H3,(H,29,30,31)
PDB

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n/an/a 4.5n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with either Nav 1.7 or with Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro auto...

US Patent US9346798 (2016)


BindingDB Entry DOI: 10.7270/Q24X56N2
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))		BDBM231307
PNG
(US9346798, 54)
Show SMILES FC(F)(F)c1ccc(N2CCOc3cc(ccc23)S(=O)(=O)Nc2nccs2)c(c1)-c1cncnc1
Show InChI InChI=1S/C22H16F3N5O3S2/c23-22(24,25)15-1-3-18(17(9-15)14-11-26-13-27-12-14)30-6-7-33-20-10-16(2-4-19(20)30)35(31,32)29-21-28-5-8-34-21/h1-5,8-13H,6-7H2,(H,28,29)
PDB

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n/an/a 11.5n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with either Nav 1.7 or with Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro auto...

US Patent US9346798 (2016)


BindingDB Entry DOI: 10.7270/Q24X56N2
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))		BDBM231308
PNG
(US9346798, 55)
Show SMILES FC(F)(F)c1ccc(N2CCOc3cc(ccc23)S(=O)(=O)Nc2ccno2)c(Cl)c1
Show InChI InChI=1S/C18H13ClF3N3O4S/c19-13-9-11(18(20,21)22)1-3-14(13)25-7-8-28-16-10-12(2-4-15(16)25)30(26,27)24-17-5-6-23-29-17/h1-6,9-10,24H,7-8H2
PDB

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n/an/a 2.92E+3n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with either Nav 1.7 or with Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro auto...

US Patent US9346798 (2016)


BindingDB Entry DOI: 10.7270/Q24X56N2
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))		BDBM231314
PNG
(US9346798, 61)
Show SMILES FC(F)(F)c1ccc(N2CCOc3cc(ccc23)S(=O)(=O)Nc2cscn2)c(Br)c1
Show InChI InChI=1S/C18H13BrF3N3O3S2/c19-13-7-11(18(20,21)22)1-3-14(13)25-5-6-28-16-8-12(2-4-15(16)25)30(26,27)24-17-9-29-10-23-17/h1-4,7-10,24H,5-6H2
PDB

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n/an/a 679n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with either Nav 1.7 or with Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro auto...

US Patent US9346798 (2016)


BindingDB Entry DOI: 10.7270/Q24X56N2
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))		BDBM231318
PNG
(US9346798, 65)
Show SMILES [N-]=[N+]=Nc1ccc(N2CCOc3cc(ccc23)S(=O)(=O)Nc2nccs2)c(c1)C1=CCNCC1 |t:32|
Show InChI InChI=1S/C22H21N7O3S2/c23-28-26-16-1-3-19(18(13-16)15-5-7-24-8-6-15)29-10-11-32-21-14-17(2-4-20(21)29)34(30,31)27-22-25-9-12-33-22/h1-5,9,12-14,24H,6-8,10-11H2,(H,25,27)
PDB

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n/an/a 24n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with either Nav 1.7 or with Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro auto...

US Patent US9346798 (2016)


BindingDB Entry DOI: 10.7270/Q24X56N2
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))		BDBM231332
PNG
(US9346798, 79)
Show SMILES Cc1ccc(F)cc1N1CCOc2cc(ccc12)S(=O)(=O)Nc1nccs1
Show InChI InChI=1S/C18H16FN3O3S2/c1-12-2-3-13(19)10-16(12)22-7-8-25-17-11-14(4-5-15(17)22)27(23,24)21-18-20-6-9-26-18/h2-6,9-11H,7-8H2,1H3,(H,20,21)
PDB

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n/an/a 216n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with either Nav 1.7 or with Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro auto...

US Patent US9346798 (2016)


BindingDB Entry DOI: 10.7270/Q24X56N2
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))		BDBM231341
PNG
(US9346798, 88)
Show SMILES FC(F)(F)c1ccc(N2CCOc3cc(ccc23)S(=O)(=O)Nc2cnccn2)c(c1)C1=CCNCC1 |t:34|
Show InChI InChI=1S/C24H22F3N5O3S/c25-24(26,27)17-1-3-20(19(13-17)16-5-7-28-8-6-16)32-11-12-35-22-14-18(2-4-21(22)32)36(33,34)31-23-15-29-9-10-30-23/h1-5,9-10,13-15,28H,6-8,11-12H2,(H,30,31)
PDB

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n/an/a 224n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with either Nav 1.7 or with Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro auto...

US Patent US9346798 (2016)


BindingDB Entry DOI: 10.7270/Q24X56N2
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))		BDBM231349
PNG
(US9346798, 96)
Show SMILES CC1COc2cc(ccc2N1c1ccc(cc1C#N)C(F)(F)F)S(=O)(=O)Nc1nccs1
Show InChI InChI=1S/C20H15F3N4O3S2/c1-12-11-30-18-9-15(32(28,29)26-19-25-6-7-31-19)3-5-17(18)27(12)16-4-2-14(20(21,22)23)8-13(16)10-24/h2-9,12H,11H2,1H3,(H,25,26)
PDB

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n/an/a 823n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with either Nav 1.7 or with Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro auto...

US Patent US9346798 (2016)


BindingDB Entry DOI: 10.7270/Q24X56N2
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))		BDBM231353
PNG
(US9346798, 100 | US9346798, 102)
Show SMILES CCC1CN(c2ccc(cc2O1)S(=O)(=O)Nc1nccs1)c1ccc(cc1C#N)C(F)(F)F
Show InChI InChI=1S/C21H17F3N4O3S2/c1-2-15-12-28(17-5-3-14(21(22,23)24)9-13(17)11-25)18-6-4-16(10-19(18)31-15)33(29,30)27-20-26-7-8-32-20/h3-10,15H,2,12H2,1H3,(H,26,27)
PDB

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n/an/a 679n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with either Nav 1.7 or with Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro auto...

US Patent US9346798 (2016)


BindingDB Entry DOI: 10.7270/Q24X56N2
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))		BDBM231358
PNG
(US9346798, 105)
Show SMILES COc1cc(Cl)ccc1N1C[C@@H](C)Oc2cc(ccc12)S(=O)(=O)Nc1nccs1 |r|
Show InChI InChI=1S/C19H18ClN3O4S2/c1-12-11-23(15-5-3-13(20)9-17(15)26-2)16-6-4-14(10-18(16)27-12)29(24,25)22-19-21-7-8-28-19/h3-10,12H,11H2,1-2H3,(H,21,22)/t12-/m1/s1
PDB

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n/an/a 53.5n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with either Nav 1.7 or with Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro auto...

US Patent US9346798 (2016)


BindingDB Entry DOI: 10.7270/Q24X56N2
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))		BDBM231359
PNG
(US9346798, 106)
Show SMILES COc1cc(ccc1N1CC(C)Oc2cc(ccc12)S(=O)(=O)Nc1nccs1)C#N
Show InChI InChI=1S/C20H18N4O4S2/c1-13-12-24(16-5-3-14(11-21)9-18(16)27-2)17-6-4-15(10-19(17)28-13)30(25,26)23-20-22-7-8-29-20/h3-10,13H,12H2,1-2H3,(H,22,23)
PDB

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n/an/a 42.5n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with either Nav 1.7 or with Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro auto...

US Patent US9346798 (2016)


BindingDB Entry DOI: 10.7270/Q24X56N2
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))		BDBM231361
PNG
(US9346798, 108)
Show SMILES COc1cc(ccc1N1C[C@@H](C)Oc2cc(ccc12)S(=O)(=O)Nc1nccs1)C#N |r|
Show InChI InChI=1S/C20H18N4O4S2/c1-13-12-24(16-5-3-14(11-21)9-18(16)27-2)17-6-4-15(10-19(17)28-13)30(25,26)23-20-22-7-8-29-20/h3-10,13H,12H2,1-2H3,(H,22,23)/t13-/m1/s1
PDB

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n/an/a 45.5n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with either Nav 1.7 or with Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro auto...

US Patent US9346798 (2016)


BindingDB Entry DOI: 10.7270/Q24X56N2
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))		BDBM231364
PNG
(US9346798, 111)
Show SMILES COc1ncc(Cl)cc1N1CCOc2cc(ccc12)S(=O)(=O)Nc1nccs1
Show InChI InChI=1S/C17H15ClN4O4S2/c1-25-16-14(8-11(18)10-20-16)22-5-6-26-15-9-12(2-3-13(15)22)28(23,24)21-17-19-4-7-27-17/h2-4,7-10H,5-6H2,1H3,(H,19,21)
PDB

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n/an/a 33.5n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with either Nav 1.7 or with Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro auto...

US Patent US9346798 (2016)


BindingDB Entry DOI: 10.7270/Q24X56N2
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))		BDBM231366
PNG
(US9346798, 113)
Show SMILES FC(F)(F)COc1ccc(cc1)N1CCOc2cc(ccc12)S(=O)(=O)Nc1nccs1
Show InChI InChI=1S/C19H16F3N3O4S2/c20-19(21,22)12-29-14-3-1-13(2-4-14)25-8-9-28-17-11-15(5-6-16(17)25)31(26,27)24-18-23-7-10-30-18/h1-7,10-11H,8-9,12H2,(H,23,24)
PDB

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n/an/a 891n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with either Nav 1.7 or with Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro auto...

US Patent US9346798 (2016)


BindingDB Entry DOI: 10.7270/Q24X56N2
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))		BDBM231367
PNG
(US9346798, 114)
Show SMILES COc1ccc(cc1N1CCOc2cc(ccc12)S(=O)(=O)Nc1nccs1)C(F)(F)F
Show InChI InChI=1S/C19H16F3N3O4S2/c1-28-16-5-2-12(19(20,21)22)10-15(16)25-7-8-29-17-11-13(3-4-14(17)25)31(26,27)24-18-23-6-9-30-18/h2-6,9-11H,7-8H2,1H3,(H,23,24)
PDB

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n/an/a 40.5n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with either Nav 1.7 or with Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro auto...

US Patent US9346798 (2016)


BindingDB Entry DOI: 10.7270/Q24X56N2
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))		BDBM231370
PNG
(US9346798, 117)
Show SMILES O=S(=O)(Nc1nccs1)c1ccc2N(CCOc2c1)c1cncc(c1)C#N
Show InChI InChI=1S/C17H13N5O3S2/c18-9-12-7-13(11-19-10-12)22-4-5-25-16-8-14(1-2-15(16)22)27(23,24)21-17-20-3-6-26-17/h1-3,6-8,10-11H,4-5H2,(H,20,21)
PDB

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n/an/a 2.14E+3n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with either Nav 1.7 or with Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro auto...

US Patent US9346798 (2016)


BindingDB Entry DOI: 10.7270/Q24X56N2
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))		BDBM231393
PNG
(US9346798, 140)
Show SMILES Cc1cc(OC(F)(F)F)ccc1N1CCOc2cc(ccc12)S(=O)(=O)Nc1nccs1
Show InChI InChI=1S/C19H16F3N3O4S2/c1-12-10-13(29-19(20,21)22)2-4-15(12)25-7-8-28-17-11-14(3-5-16(17)25)31(26,27)24-18-23-6-9-30-18/h2-6,9-11H,7-8H2,1H3,(H,23,24)
PDB

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n/an/a 451n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with either Nav 1.7 or with Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro auto...

US Patent US9346798 (2016)


BindingDB Entry DOI: 10.7270/Q24X56N2
More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%