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Patent code US9346798

Compile Data Set for Download or QSAR

Found 678 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))		BDBM231258
PNG
(US9346798, 5)
Show SMILES FC(F)(F)c1ccc(N2CCOc3cc(ccc23)S(=O)(=O)Nc2nccs2)c(Cl)c1
Show InChI InChI=1S/C18H13ClF3N3O3S2/c19-13-9-11(18(20,21)22)1-3-14(13)25-6-7-28-16-10-12(2-4-15(16)25)30(26,27)24-17-23-5-8-29-17/h1-5,8-10H,6-7H2,(H,23,24)
PDB

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US Patent
n/an/a 4.03E+3n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with either Nav 1.7 or with Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro auto...

US Patent US9346798 (2016)


BindingDB Entry DOI: 10.7270/Q24X56N2
More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))		BDBM231261
PNG
(US9346798, 8)
Show SMILES NCc1nsc(NS(=O)(=O)c2ccc3N(CCOc3c2)c2ccc(cc2Cl)C(F)(F)F)n1
Show InChI InChI=1S/C18H15ClF3N5O3S2/c19-12-7-10(18(20,21)22)1-3-13(12)27-5-6-30-15-8-11(2-4-14(15)27)32(28,29)26-17-24-16(9-23)25-31-17/h1-4,7-8H,5-6,9,23H2,(H,24,25,26)
PDB

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US Patent
n/an/a>1.00E+4n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with either Nav 1.7 or with Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro auto...

US Patent US9346798 (2016)


BindingDB Entry DOI: 10.7270/Q24X56N2
More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))		BDBM231263
PNG
(US9346798, 10)
Show SMILES Cc1nsc(NS(=O)(=O)c2ccc3N(CCOc3c2)c2ccc(cc2Cl)C(F)(F)F)n1
Show InChI InChI=1S/C18H14ClF3N4O3S2/c1-10-23-17(30-24-10)25-31(27,28)12-3-5-15-16(9-12)29-7-6-26(15)14-4-2-11(8-13(14)19)18(20,21)22/h2-5,8-9H,6-7H2,1H3,(H,23,24,25)
PDB

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n/an/a>1.00E+4n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with either Nav 1.7 or with Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro auto...

US Patent US9346798 (2016)


BindingDB Entry DOI: 10.7270/Q24X56N2
More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))		BDBM231269
PNG
(US9346798, 16)
Show SMILES FC(F)(F)c1ccc(N2CCOc3cc(ccc23)S(=O)(=O)Nc2ncccn2)c(Cl)c1
Show InChI InChI=1S/C19H14ClF3N4O3S/c20-14-10-12(19(21,22)23)2-4-15(14)27-8-9-30-17-11-13(3-5-16(17)27)31(28,29)26-18-24-6-1-7-25-18/h1-7,10-11H,8-9H2,(H,24,25,26)
PDB

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n/an/a>1.00E+4n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with either Nav 1.7 or with Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro auto...

US Patent US9346798 (2016)


BindingDB Entry DOI: 10.7270/Q24X56N2
More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))		BDBM231271
PNG
(US9346798, 18)
Show SMILES FC(F)(F)c1ccc(N2CCNc3cc(ccc23)S(=O)(=O)Nc2ncns2)c(Cl)c1
Show InChI InChI=1S/C17H13ClF3N5O2S2/c18-12-7-10(17(19,20)21)1-3-14(12)26-6-5-22-13-8-11(2-4-15(13)26)30(27,28)25-16-23-9-24-29-16/h1-4,7-9,22H,5-6H2,(H,23,24,25)
PDB

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n/an/a>1.00E+4n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with either Nav 1.7 or with Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro auto...

US Patent US9346798 (2016)


BindingDB Entry DOI: 10.7270/Q24X56N2
More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))		BDBM231282
PNG
(US9346798, 29)
Show SMILES Nc1cc(ccn1)-c1cc(ccc1N1CCOc2cc(ccc12)S(=O)(=O)Nc1ncns1)C(F)(F)F
Show InChI InChI=1S/C22H17F3N6O3S2/c23-22(24,25)14-1-3-17(16(10-14)13-5-6-27-20(26)9-13)31-7-8-34-19-11-15(2-4-18(19)31)36(32,33)30-21-28-12-29-35-21/h1-6,9-12H,7-8H2,(H2,26,27)(H,28,29,30)
PDB

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n/an/a 634n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with either Nav 1.7 or with Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro auto...

US Patent US9346798 (2016)


BindingDB Entry DOI: 10.7270/Q24X56N2
More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))		BDBM231284
PNG
(US9346798, 31)
Show SMILES FC(F)(F)c1ccc(N2CCOc3cc(ccc23)S(=O)(=O)Nc2ncns2)c(c1)C#N
Show InChI InChI=1S/C18H12F3N5O3S2/c19-18(20,21)12-1-3-14(11(7-12)9-22)26-5-6-29-16-8-13(2-4-15(16)26)31(27,28)25-17-23-10-24-30-17/h1-4,7-8,10H,5-6H2,(H,23,24,25)
PDB

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n/an/a 1.46E+3n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with either Nav 1.7 or with Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro auto...

US Patent US9346798 (2016)


BindingDB Entry DOI: 10.7270/Q24X56N2
More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))		BDBM231289
PNG
(US9346798, 36)
Show SMILES O=S(=O)(Nc1ncns1)c1ccc2N(CCOc2c1)c1cccc2ccccc12
Show InChI InChI=1S/C20H16N4O3S2/c25-29(26,23-20-21-13-22-28-20)15-8-9-18-19(12-15)27-11-10-24(18)17-7-3-5-14-4-1-2-6-16(14)17/h1-9,12-13H,10-11H2,(H,21,22,23)
PDB

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n/an/a>1.00E+4n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with either Nav 1.7 or with Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro auto...

US Patent US9346798 (2016)


BindingDB Entry DOI: 10.7270/Q24X56N2
More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))		BDBM231310
PNG
(US9346798, 57)
Show SMILES O=S(=O)(Nc1ncns1)c1ccc2N(CCOc2c1)c1ccccc1C#N
Show InChI InChI=1S/C17H13N5O3S2/c18-10-12-3-1-2-4-14(12)22-7-8-25-16-9-13(5-6-15(16)22)27(23,24)21-17-19-11-20-26-17/h1-6,9,11H,7-8H2,(H,19,20,21)
PDB

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US Patent
n/an/a 6.70E+3n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with either Nav 1.7 or with Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro auto...

US Patent US9346798 (2016)


BindingDB Entry DOI: 10.7270/Q24X56N2
More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))		BDBM231311
PNG
(US9346798, 58)
Show SMILES O=S(=O)(Nc1nccs1)c1ccc2N(CCOc2c1)c1ccccc1C#N
Show InChI InChI=1S/C18H14N4O3S2/c19-12-13-3-1-2-4-15(13)22-8-9-25-17-11-14(5-6-16(17)22)27(23,24)21-18-20-7-10-26-18/h1-7,10-11H,8-9H2,(H,20,21)
PDB

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n/an/a 6.30E+3n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with either Nav 1.7 or with Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro auto...

US Patent US9346798 (2016)


BindingDB Entry DOI: 10.7270/Q24X56N2
More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))		BDBM231313
PNG
(US9346798, 60)
Show SMILES FC(F)(F)c1ccc(N2CCOc3cc(ccc23)S(=O)(=O)Nc2ccccn2)c(Br)c1
Show InChI InChI=1S/C20H15BrF3N3O3S/c21-15-11-13(20(22,23)24)4-6-16(15)27-9-10-30-18-12-14(5-7-17(18)27)31(28,29)26-19-3-1-2-8-25-19/h1-8,11-12H,9-10H2,(H,25,26)
PDB

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n/an/a>1.00E+4n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with either Nav 1.7 or with Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro auto...

US Patent US9346798 (2016)


BindingDB Entry DOI: 10.7270/Q24X56N2
More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))		BDBM231314
PNG
(US9346798, 61)
Show SMILES FC(F)(F)c1ccc(N2CCOc3cc(ccc23)S(=O)(=O)Nc2cscn2)c(Br)c1
Show InChI InChI=1S/C18H13BrF3N3O3S2/c19-13-7-11(18(20,21)22)1-3-14(13)25-5-6-28-16-8-12(2-4-15(16)25)30(26,27)24-17-9-29-10-23-17/h1-4,7-10,24H,5-6H2
PDB

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n/an/a>1.00E+4n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with either Nav 1.7 or with Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro auto...

US Patent US9346798 (2016)


BindingDB Entry DOI: 10.7270/Q24X56N2
More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))		BDBM231315
PNG
(US9346798, 62)
Show SMILES FC(F)(F)c1ccc(N2CCOc3cc(ccc23)S(=O)(=O)Nc2ccccn2)c(c1)C1=CCNCC1 |t:34|
Show InChI InChI=1S/C25H23F3N4O3S/c26-25(27,28)18-4-6-21(20(15-18)17-8-11-29-12-9-17)32-13-14-35-23-16-19(5-7-22(23)32)36(33,34)31-24-3-1-2-10-30-24/h1-8,10,15-16,29H,9,11-14H2,(H,30,31)
PDB

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n/an/a>1.00E+4n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with either Nav 1.7 or with Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro auto...

US Patent US9346798 (2016)


BindingDB Entry DOI: 10.7270/Q24X56N2
More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))		BDBM231316
PNG
(US9346798, 63)
Show SMILES FC(F)(F)c1ccc(N2CCOc3cc(ccc23)S(=O)(=O)Nc2cscn2)c(c1)C1=CCNCC1 |t:33|
Show InChI InChI=1S/C23H21F3N4O3S2/c24-23(25,26)16-1-3-19(18(11-16)15-5-7-27-8-6-15)30-9-10-33-21-12-17(2-4-20(21)30)35(31,32)29-22-13-34-14-28-22/h1-5,11-14,27,29H,6-10H2
PDB

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n/an/a 2.67E+3n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with either Nav 1.7 or with Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro auto...

US Patent US9346798 (2016)


BindingDB Entry DOI: 10.7270/Q24X56N2
More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))		BDBM231317
PNG
(US9346798, 64)
Show SMILES Brc1cc(ccc1N1CCOc2cc(ccc12)S(=O)(=O)Nc1nccs1)N=[N+]=[N-]
Show InChI InChI=1S/C17H13BrN6O3S2/c18-13-9-11(21-23-19)1-3-14(13)24-6-7-27-16-10-12(2-4-15(16)24)29(25,26)22-17-20-5-8-28-17/h1-5,8-10H,6-7H2,(H,20,22)
PDB

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n/an/a>1.00E+4n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with either Nav 1.7 or with Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro auto...

US Patent US9346798 (2016)


BindingDB Entry DOI: 10.7270/Q24X56N2
More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))		BDBM231340
PNG
(US9346798, 87)
Show SMILES FC(F)(F)c1ccc(N2CCOc3cc(ccc23)S(=O)(=O)Nc2cccnn2)c(c1)C1=CCNCC1 |t:34|
Show InChI InChI=1S/C24H22F3N5O3S/c25-24(26,27)17-3-5-20(19(14-17)16-7-10-28-11-8-16)32-12-13-35-22-15-18(4-6-21(22)32)36(33,34)31-23-2-1-9-29-30-23/h1-7,9,14-15,28H,8,10-13H2,(H,30,31)
PDB

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n/an/a>1.00E+4n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with either Nav 1.7 or with Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro auto...

US Patent US9346798 (2016)


BindingDB Entry DOI: 10.7270/Q24X56N2
More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))		BDBM231352
PNG
(US9346798, 99)
Show SMILES FC(F)(F)c1cnc(N2CCOc3cc(ccc23)S(=O)(=O)Nc2ccncn2)c(Cl)c1
Show InChI InChI=1S/C18H13ClF3N5O3S/c19-13-7-11(18(20,21)22)9-24-17(13)27-5-6-30-15-8-12(1-2-14(15)27)31(28,29)26-16-3-4-23-10-25-16/h1-4,7-10H,5-6H2,(H,23,25,26)
PDB

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n/an/a>1.00E+4n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with either Nav 1.7 or with Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro auto...

US Patent US9346798 (2016)


BindingDB Entry DOI: 10.7270/Q24X56N2
More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))		BDBM231366
PNG
(US9346798, 113)
Show SMILES FC(F)(F)COc1ccc(cc1)N1CCOc2cc(ccc12)S(=O)(=O)Nc1nccs1
Show InChI InChI=1S/C19H16F3N3O4S2/c20-19(21,22)12-29-14-3-1-13(2-4-14)25-8-9-28-17-11-15(5-6-16(17)25)31(26,27)24-18-23-7-10-30-18/h1-7,10-11H,8-9,12H2,(H,23,24)
PDB

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n/an/a 3.37E+3n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with either Nav 1.7 or with Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro auto...

US Patent US9346798 (2016)


BindingDB Entry DOI: 10.7270/Q24X56N2
More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))		BDBM231375
PNG
(US9346798, 122)
Show SMILES FC(F)(F)c1ccc(cn1)N1CCOc2cc(ccc12)S(=O)(=O)Nc1nccs1
Show InChI InChI=1S/C17H13F3N4O3S2/c18-17(19,20)15-4-1-11(10-22-15)24-6-7-27-14-9-12(2-3-13(14)24)29(25,26)23-16-21-5-8-28-16/h1-5,8-10H,6-7H2,(H,21,23)
PDB

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n/an/a 7.03E+3n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with either Nav 1.7 or with Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro auto...

US Patent US9346798 (2016)


BindingDB Entry DOI: 10.7270/Q24X56N2
More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))		BDBM231382
PNG
(US9346798, 129)
Show SMILES FC1(F)Oc2cccc(N3CCOc4cc(ccc34)S(=O)(=O)Nc3nccs3)c2O1
Show InChI InChI=1S/C18H13F2N3O5S2/c19-18(20)27-14-3-1-2-13(16(14)28-18)23-7-8-26-15-10-11(4-5-12(15)23)30(24,25)22-17-21-6-9-29-17/h1-6,9-10H,7-8H2,(H,21,22)
PDB

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UniProtKB/SwissProt

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n/an/a>1.00E+4n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with either Nav 1.7 or with Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro auto...

US Patent US9346798 (2016)


BindingDB Entry DOI: 10.7270/Q24X56N2
More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))		BDBM231385
PNG
(US9346798, 132)
Show SMILES Cc1ccc(N2CCOc3cc(ccc23)S(=O)(=O)Nc2nccs2)c(C)n1
Show InChI InChI=1S/C18H18N4O3S2/c1-12-3-5-15(13(2)20-12)22-8-9-25-17-11-14(4-6-16(17)22)27(23,24)21-18-19-7-10-26-18/h3-7,10-11H,8-9H2,1-2H3,(H,19,21)
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n/an/a>1.00E+4n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with either Nav 1.7 or with Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro auto...

US Patent US9346798 (2016)


BindingDB Entry DOI: 10.7270/Q24X56N2
More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))		BDBM231387
PNG
(US9346798, 134)
Show SMILES Cc1cc(N2CCOc3cc(ccc23)S(=O)(=O)Nc2nccs2)c(C)cn1
Show InChI InChI=1S/C18H18N4O3S2/c1-12-11-20-13(2)9-16(12)22-6-7-25-17-10-14(3-4-15(17)22)27(23,24)21-18-19-5-8-26-18/h3-5,8-11H,6-7H2,1-2H3,(H,19,21)
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n/an/a>1.00E+4n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with either Nav 1.7 or with Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro auto...

US Patent US9346798 (2016)


BindingDB Entry DOI: 10.7270/Q24X56N2
More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))		BDBM231406
PNG
(US9346798, 153)
Show SMILES COc1ccc(N2CCOc3cc(ccc23)S(=O)(=O)Nc2nccs2)c(c1)C#N
Show InChI InChI=1S/C19H16N4O4S2/c1-26-14-2-4-16(13(10-14)12-20)23-7-8-27-18-11-15(3-5-17(18)23)29(24,25)22-19-21-6-9-28-19/h2-6,9-11H,7-8H2,1H3,(H,21,22)
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n/an/a>1.00E+4n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with either Nav 1.7 or with Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro auto...

US Patent US9346798 (2016)


BindingDB Entry DOI: 10.7270/Q24X56N2
More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))		BDBM231424
PNG
(US9346798, 171)
Show SMILES Clc1cccc(N2CCOc3cc(ccc23)S(=O)(=O)Nc2nccs2)c1Cl
Show InChI InChI=1S/C17H13Cl2N3O3S2/c18-12-2-1-3-14(16(12)19)22-7-8-25-15-10-11(4-5-13(15)22)27(23,24)21-17-20-6-9-26-17/h1-6,9-10H,7-8H2,(H,20,21)
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n/an/a 6.44E+3n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with either Nav 1.7 or with Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro auto...

US Patent US9346798 (2016)


BindingDB Entry DOI: 10.7270/Q24X56N2
More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))		BDBM231439
PNG
(US9346798, 186)
Show SMILES COc1cc(Cl)ccc1N1CCOc2cc(ccc12)S(=O)(=O)Nc1nccs1
Show InChI InChI=1S/C18H16ClN3O4S2/c1-25-16-10-12(19)2-4-14(16)22-7-8-26-17-11-13(3-5-15(17)22)28(23,24)21-18-20-6-9-27-18/h2-6,9-11H,7-8H2,1H3,(H,20,21)
PDB

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n/an/a 7.72E+3n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with either Nav 1.7 or with Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro auto...

US Patent US9346798 (2016)


BindingDB Entry DOI: 10.7270/Q24X56N2
More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))		BDBM231446
PNG
(US9346798, 193)
Show SMILES FC(F)Oc1cc(Cl)ccc1N1CCOc2cc(ccc12)S(=O)(=O)Nc1nccs1
Show InChI InChI=1S/C18H14ClF2N3O4S2/c19-11-1-3-14(16(9-11)28-17(20)21)24-6-7-27-15-10-12(2-4-13(15)24)30(25,26)23-18-22-5-8-29-18/h1-5,8-10,17H,6-7H2,(H,22,23)
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n/an/a 1.56E+3n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with either Nav 1.7 or with Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro auto...

US Patent US9346798 (2016)


BindingDB Entry DOI: 10.7270/Q24X56N2
More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))		BDBM231452
PNG
(US9346798, 199)
Show SMILES Fc1ccc(cc1)-c1ccc(N2CCOc3cc(ccc23)S(=O)(=O)Nc2nccs2)c(c1)C#N
Show InChI InChI=1S/C24H17FN4O3S2/c25-19-4-1-16(2-5-19)17-3-7-21(18(13-17)15-26)29-10-11-32-23-14-20(6-8-22(23)29)34(30,31)28-24-27-9-12-33-24/h1-9,12-14H,10-11H2,(H,27,28)
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n/an/a 1.22E+3n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with either Nav 1.7 or with Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro auto...

US Patent US9346798 (2016)


BindingDB Entry DOI: 10.7270/Q24X56N2
More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))		BDBM231455
PNG
(US9346798, 202)
Show SMILES CC(C)c1ccc(N2CCOc3cc(ccc23)S(=O)(=O)Nc2nccs2)c(c1)C#N
Show InChI InChI=1S/C21H20N4O3S2/c1-14(2)15-3-5-18(16(11-15)13-22)25-8-9-28-20-12-17(4-6-19(20)25)30(26,27)24-21-23-7-10-29-21/h3-7,10-12,14H,8-9H2,1-2H3,(H,23,24)
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n/an/a 686n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with either Nav 1.7 or with Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro auto...

US Patent US9346798 (2016)


BindingDB Entry DOI: 10.7270/Q24X56N2
More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))		BDBM231467
PNG
(US9346798, 214)
Show SMILES COc1nc(ccc1N1CCOc2cc(ccc12)S(=O)(=O)Nc1nccs1)C(F)(F)F
Show InChI InChI=1S/C18H15F3N4O4S2/c1-28-16-13(4-5-15(23-16)18(19,20)21)25-7-8-29-14-10-11(2-3-12(14)25)31(26,27)24-17-22-6-9-30-17/h2-6,9-10H,7-8H2,1H3,(H,22,24)
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n/an/a>1.00E+4n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with either Nav 1.7 or with Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro auto...

US Patent US9346798 (2016)


BindingDB Entry DOI: 10.7270/Q24X56N2
More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))		BDBM231479
PNG
(US9346798, 228)
Show SMILES CCN(CC)C(=O)CN1CCOc2cc(ccc12)S(=O)(=O)Nc1nccs1
Show InChI InChI=1S/C17H22N4O4S2/c1-3-20(4-2)16(22)12-21-8-9-25-15-11-13(5-6-14(15)21)27(23,24)19-17-18-7-10-26-17/h5-7,10-11H,3-4,8-9,12H2,1-2H3,(H,18,19)
PDB

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n/an/a>1.00E+4n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with either Nav 1.7 or with Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro auto...

US Patent US9346798 (2016)


BindingDB Entry DOI: 10.7270/Q24X56N2
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))		BDBM231259
PNG
(US9346798, 6)
Show SMILES CC(C)(C)OC(=O)N1CCC(=CC1)c1cc(ccc1N1CCOc2cc(ccc12)S(=O)(=O)Nc1ncns1)C(F)(F)F |c:10|
Show InChI InChI=1S/C27H28F3N5O5S2/c1-26(2,3)40-25(36)34-10-8-17(9-11-34)20-14-18(27(28,29)30)4-6-21(20)35-12-13-39-23-15-19(5-7-22(23)35)42(37,38)33-24-31-16-32-41-24/h4-8,14-16H,9-13H2,1-3H3,(H,31,32,33)
PDB

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n/an/a 81.8n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with either Nav 1.7 or with Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro auto...

US Patent US9346798 (2016)


BindingDB Entry DOI: 10.7270/Q24X56N2
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))		BDBM231262
PNG
(US9346798, 9)
Show SMILES FC(F)(F)c1ccc(N2CCOc3cc(ccc23)S(=O)(=O)Nc2cc(Cl)ncn2)c(Cl)c1
Show InChI InChI=1S/C19H13Cl2F3N4O3S/c20-13-7-11(19(22,23)24)1-3-14(13)28-5-6-31-16-8-12(2-4-15(16)28)32(29,30)27-18-9-17(21)25-10-26-18/h1-4,7-10H,5-6H2,(H,25,26,27)
PDB

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n/an/a 876n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with either Nav 1.7 or with Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro auto...

US Patent US9346798 (2016)


BindingDB Entry DOI: 10.7270/Q24X56N2
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))		BDBM231266
PNG
(US9346798, 13)
Show SMILES FC(F)(F)c1ccc(N2CCOc3cc(ccc23)S(=O)(=O)Nc2ccon2)c(Cl)c1
Show InChI InChI=1S/C18H13ClF3N3O4S/c19-13-9-11(18(20,21)22)1-3-14(13)25-6-8-28-16-10-12(2-4-15(16)25)30(26,27)24-17-5-7-29-23-17/h1-5,7,9-10H,6,8H2,(H,23,24)
PDB

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n/an/a 1.72E+3n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with either Nav 1.7 or with Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro auto...

US Patent US9346798 (2016)


BindingDB Entry DOI: 10.7270/Q24X56N2
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))		BDBM231276
PNG
(US9346798, 23)
Show SMILES FC(F)(F)c1ccc(N2CCOc3cc(ccc23)S(=O)(=O)Nc2ncns2)c(c1)-c1cncnc1
Show InChI InChI=1S/C21H15F3N6O3S2/c22-21(23,24)14-1-3-17(16(7-14)13-9-25-11-26-10-13)30-5-6-33-19-8-15(2-4-18(19)30)35(31,32)29-20-27-12-28-34-20/h1-4,7-12H,5-6H2,(H,27,28,29)
PDB

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n/an/a 29.8n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with either Nav 1.7 or with Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro auto...

US Patent US9346798 (2016)


BindingDB Entry DOI: 10.7270/Q24X56N2
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))		BDBM231282
PNG
(US9346798, 29)
Show SMILES Nc1cc(ccn1)-c1cc(ccc1N1CCOc2cc(ccc12)S(=O)(=O)Nc1ncns1)C(F)(F)F
Show InChI InChI=1S/C22H17F3N6O3S2/c23-22(24,25)14-1-3-17(16(10-14)13-5-6-27-20(26)9-13)31-7-8-34-19-11-15(2-4-18(19)31)36(32,33)30-21-28-12-29-35-21/h1-6,9-12H,7-8H2,(H2,26,27)(H,28,29,30)
PDB

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n/an/a 9.5n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with either Nav 1.7 or with Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro auto...

US Patent US9346798 (2016)


BindingDB Entry DOI: 10.7270/Q24X56N2
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))		BDBM231285
PNG
(US9346798, 32)
Show SMILES FC(F)(F)c1ccc(N2CCOc3cc(ccc23)S(=O)(=O)Nc2ccncn2)c(Cl)c1
Show InChI InChI=1S/C19H14ClF3N4O3S/c20-14-9-12(19(21,22)23)1-3-15(14)27-7-8-30-17-10-13(2-4-16(17)27)31(28,29)26-18-5-6-24-11-25-18/h1-6,9-11H,7-8H2,(H,24,25,26)
PDB

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n/an/a 72.5n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with either Nav 1.7 or with Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro auto...

US Patent US9346798 (2016)


BindingDB Entry DOI: 10.7270/Q24X56N2
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))		BDBM231295
PNG
(US9346798, 42)
Show SMILES Cn1nccc1-c1cc(ccc1N1CCOc2cc(ccc12)S(=O)(=O)Nc1nccs1)C(F)(F)F
Show InChI InChI=1S/C22H18F3N5O3S2/c1-29-17(6-7-27-29)16-12-14(22(23,24)25)2-4-18(16)30-9-10-33-20-13-15(3-5-19(20)30)35(31,32)28-21-26-8-11-34-21/h2-8,11-13H,9-10H2,1H3,(H,26,28)
PDB

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n/an/a 121n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with either Nav 1.7 or with Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro auto...

US Patent US9346798 (2016)


BindingDB Entry DOI: 10.7270/Q24X56N2
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))		BDBM231305
PNG
(US9346798, 52)
Show SMILES Clc1ccc(N2CCOc3cc(ccc23)S(=O)(=O)Nc2nccs2)c(c1)C1=CCNCC1 |t:30|
Show InChI InChI=1S/C22H21ClN4O3S2/c23-16-1-3-19(18(13-16)15-5-7-24-8-6-15)27-10-11-30-21-14-17(2-4-20(21)27)32(28,29)26-22-25-9-12-31-22/h1-5,9,12-14,24H,6-8,10-11H2,(H,25,26)
PDB

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n/an/a 4.5n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with either Nav 1.7 or with Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro auto...

US Patent US9346798 (2016)


BindingDB Entry DOI: 10.7270/Q24X56N2
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))		BDBM231307
PNG
(US9346798, 54)
Show SMILES FC(F)(F)c1ccc(N2CCOc3cc(ccc23)S(=O)(=O)Nc2nccs2)c(c1)-c1cncnc1
Show InChI InChI=1S/C22H16F3N5O3S2/c23-22(24,25)15-1-3-18(17(9-15)14-11-26-13-27-12-14)30-6-7-33-20-10-16(2-4-19(20)30)35(31,32)29-21-28-5-8-34-21/h1-5,8-13H,6-7H2,(H,28,29)
PDB

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n/an/a 11.5n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with either Nav 1.7 or with Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro auto...

US Patent US9346798 (2016)


BindingDB Entry DOI: 10.7270/Q24X56N2
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))		BDBM231309
PNG
(US9346798, 56)
Show SMILES Clc1ccc(N2CCOc3cc(ccc23)S(=O)(=O)Nc2nccs2)c(c1)C#N
Show InChI InChI=1S/C18H13ClN4O3S2/c19-13-1-3-15(12(9-13)11-20)23-6-7-26-17-10-14(2-4-16(17)23)28(24,25)22-18-21-5-8-27-18/h1-5,8-10H,6-7H2,(H,21,22)
PDB

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n/an/a 51n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with either Nav 1.7 or with Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro auto...

US Patent US9346798 (2016)


BindingDB Entry DOI: 10.7270/Q24X56N2
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))		BDBM231311
PNG
(US9346798, 58)
Show SMILES O=S(=O)(Nc1nccs1)c1ccc2N(CCOc2c1)c1ccccc1C#N
Show InChI InChI=1S/C18H14N4O3S2/c19-12-13-3-1-2-4-15(13)22-8-9-25-17-11-14(5-6-16(17)22)27(23,24)21-18-20-7-10-26-18/h1-7,10-11H,8-9H2,(H,20,21)
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UniProtKB/SwissProt

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n/an/a 225n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with either Nav 1.7 or with Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro auto...

US Patent US9346798 (2016)


BindingDB Entry DOI: 10.7270/Q24X56N2
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))		BDBM231317
PNG
(US9346798, 64)
Show SMILES Brc1cc(ccc1N1CCOc2cc(ccc12)S(=O)(=O)Nc1nccs1)N=[N+]=[N-]
Show InChI InChI=1S/C17H13BrN6O3S2/c18-13-9-11(21-23-19)1-3-14(13)24-6-7-27-16-10-12(2-4-15(16)24)29(25,26)22-17-20-5-8-28-17/h1-5,8-10H,6-7H2,(H,20,22)
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n/an/a 418n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with either Nav 1.7 or with Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro auto...

US Patent US9346798 (2016)


BindingDB Entry DOI: 10.7270/Q24X56N2
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))		BDBM231335
PNG
(US9346798, 82)
Show SMILES Cc1ccc(cc1F)N1CCOc2cc(ccc12)S(=O)(=O)Nc1nccs1
Show InChI InChI=1S/C18H16FN3O3S2/c1-12-2-3-13(10-15(12)19)22-7-8-25-17-11-14(4-5-16(17)22)27(23,24)21-18-20-6-9-26-18/h2-6,9-11H,7-8H2,1H3,(H,20,21)
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n/an/a 7.37E+3n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with either Nav 1.7 or with Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro auto...

US Patent US9346798 (2016)


BindingDB Entry DOI: 10.7270/Q24X56N2
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))		BDBM231354
PNG
(US9346798, 101)
Show SMILES CC[C@H]1CN(c2ccc(cc2O1)S(=O)(=O)Nc1nccs1)c1ccc(cc1C#N)C(F)(F)F |r|
Show InChI InChI=1S/C21H17F3N4O3S2/c1-2-15-12-28(17-5-3-14(21(22,23)24)9-13(17)11-25)18-6-4-16(10-19(18)31-15)33(29,30)27-20-26-7-8-32-20/h3-10,15H,2,12H2,1H3,(H,26,27)/t15-/m0/s1
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n/an/a 367n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with either Nav 1.7 or with Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro auto...

US Patent US9346798 (2016)


BindingDB Entry DOI: 10.7270/Q24X56N2
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))		BDBM231360
PNG
(US9346798, 107)
Show SMILES COc1cc(ccc1N1C[C@H](C)Oc2cc(ccc12)S(=O)(=O)Nc1nccs1)C#N |r|
Show InChI InChI=1S/C20H18N4O4S2/c1-13-12-24(16-5-3-14(11-21)9-18(16)27-2)17-6-4-15(10-19(17)28-13)30(25,26)23-20-22-7-8-29-20/h3-10,13H,12H2,1-2H3,(H,22,23)/t13-/m0/s1
PDB

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n/an/a 28.5n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with either Nav 1.7 or with Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro auto...

US Patent US9346798 (2016)


BindingDB Entry DOI: 10.7270/Q24X56N2
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))		BDBM231383
PNG
(US9346798, 130)
Show SMILES Clc1cncc(c1)N1CCOc2cc(ccc12)S(=O)(=O)Nc1nccs1
Show InChI InChI=1S/C16H13ClN4O3S2/c17-11-7-12(10-18-9-11)21-4-5-24-15-8-13(1-2-14(15)21)26(22,23)20-16-19-3-6-25-16/h1-3,6-10H,4-5H2,(H,19,20)
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n/an/a 635n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with either Nav 1.7 or with Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro auto...

US Patent US9346798 (2016)


BindingDB Entry DOI: 10.7270/Q24X56N2
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))		BDBM231388
PNG
(US9346798, 135)
Show SMILES Cc1ccc(C#N)c(n1)N1CCOc2cc(ccc12)S(=O)(=O)Nc1nccs1
Show InChI InChI=1S/C18H15N5O3S2/c1-12-2-3-13(11-19)17(21-12)23-7-8-26-16-10-14(4-5-15(16)23)28(24,25)22-18-20-6-9-27-18/h2-6,9-10H,7-8H2,1H3,(H,20,22)
PDB

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n/an/a 2.68E+3n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with either Nav 1.7 or with Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro auto...

US Patent US9346798 (2016)


BindingDB Entry DOI: 10.7270/Q24X56N2
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))		BDBM231392
PNG
(US9346798, 139)
Show SMILES COc1ccc(OC)c(c1)N1CCOc2cc(ccc12)S(=O)(=O)Nc1nccs1
Show InChI InChI=1S/C19H19N3O5S2/c1-25-13-3-6-17(26-2)16(11-13)22-8-9-27-18-12-14(4-5-15(18)22)29(23,24)21-19-20-7-10-28-19/h3-7,10-12H,8-9H2,1-2H3,(H,20,21)
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n/an/a 69.5n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with either Nav 1.7 or with Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro auto...

US Patent US9346798 (2016)


BindingDB Entry DOI: 10.7270/Q24X56N2
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))		BDBM231393
PNG
(US9346798, 140)
Show SMILES Cc1cc(OC(F)(F)F)ccc1N1CCOc2cc(ccc12)S(=O)(=O)Nc1nccs1
Show InChI InChI=1S/C19H16F3N3O4S2/c1-12-10-13(29-19(20,21)22)2-4-15(12)25-7-8-28-17-11-14(3-5-16(17)25)31(26,27)24-18-23-6-9-30-18/h2-6,9-11H,7-8H2,1H3,(H,23,24)
PDB

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n/an/a 451n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with either Nav 1.7 or with Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro auto...

US Patent US9346798 (2016)


BindingDB Entry DOI: 10.7270/Q24X56N2
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))		BDBM231398
PNG
(US9346798, 145)
Show SMILES COc1ncc(cc1N1CCOc2cc(ccc12)S(=O)(=O)Nc1nccs1)C(F)(F)F
Show InChI InChI=1S/C18H15F3N4O4S2/c1-28-16-14(8-11(10-23-16)18(19,20)21)25-5-6-29-15-9-12(2-3-13(15)25)31(26,27)24-17-22-4-7-30-17/h2-4,7-10H,5-6H2,1H3,(H,22,24)
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n/an/a 235n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with either Nav 1.7 or with Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro auto...

US Patent US9346798 (2016)


BindingDB Entry DOI: 10.7270/Q24X56N2
More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%