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Patent code US9346798

Compile Data Set for Download or QSAR

Found 678 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))		BDBM231508
PNG
(US9346798, 259)
Show SMILES CCc1ccccc1N1CCOc2cc(ccc12)S(=O)(=O)Nc1nccs1
Show InChI InChI=1S/C19H19N3O3S2/c1-2-14-5-3-4-6-16(14)22-10-11-25-18-13-15(7-8-17(18)22)27(23,24)21-19-20-9-12-26-19/h3-9,12-13H,2,10-11H2,1H3,(H,20,21)
PDB

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US Patent
n/an/a 1.60E+3n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...

US Patent US9346798 (2016)


BindingDB Entry DOI: 10.7270/Q24X56N2
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))		BDBM231509
PNG
(US9346798, 260)
Show SMILES O=S(=O)(Nc1nccs1)c1ccc2N(CCOc2c1)c1ccccc1Oc1ccncc1
Show InChI InChI=1S/C22H18N4O4S2/c27-32(28,25-22-24-11-14-31-22)17-5-6-19-21(15-17)29-13-12-26(19)18-3-1-2-4-20(18)30-16-7-9-23-10-8-16/h1-11,14-15H,12-13H2,(H,24,25)
PDB

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UniProtKB/SwissProt

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US Patent
n/an/a 2.26E+3n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...

US Patent US9346798 (2016)


BindingDB Entry DOI: 10.7270/Q24X56N2
More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))		BDBM231259
PNG
(US9346798, 6)
Show SMILES CC(C)(C)OC(=O)N1CCC(=CC1)c1cc(ccc1N1CCOc2cc(ccc12)S(=O)(=O)Nc1ncns1)C(F)(F)F |c:10|
Show InChI InChI=1S/C27H28F3N5O5S2/c1-26(2,3)40-25(36)34-10-8-17(9-11-34)20-14-18(27(28,29)30)4-6-21(20)35-12-13-39-23-15-19(5-7-22(23)35)42(37,38)33-24-31-16-32-41-24/h4-8,14-16H,9-13H2,1-3H3,(H,31,32,33)
PDB

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US Patent
n/an/a 2.29E+3n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with either Nav 1.7 or with Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro auto...

US Patent US9346798 (2016)


BindingDB Entry DOI: 10.7270/Q24X56N2
More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))		BDBM231266
PNG
(US9346798, 13)
Show SMILES FC(F)(F)c1ccc(N2CCOc3cc(ccc23)S(=O)(=O)Nc2ccon2)c(Cl)c1
Show InChI InChI=1S/C18H13ClF3N3O4S/c19-13-9-11(18(20,21)22)1-3-14(13)25-6-8-28-16-10-12(2-4-15(16)25)30(26,27)24-17-5-7-29-23-17/h1-5,7,9-10H,6,8H2,(H,23,24)
PDB

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n/an/a>1.00E+4n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with either Nav 1.7 or with Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro auto...

US Patent US9346798 (2016)


BindingDB Entry DOI: 10.7270/Q24X56N2
More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))		BDBM231268
PNG
(US9346798, 15)
Show SMILES Cn1ccc(NS(=O)(=O)c2ccc3N(CCOc3c2)c2ccc(cc2Cl)C(F)(F)F)n1
Show InChI InChI=1S/C19H16ClF3N4O3S/c1-26-7-6-18(24-26)25-31(28,29)13-3-5-16-17(11-13)30-9-8-27(16)15-4-2-12(10-14(15)20)19(21,22)23/h2-7,10-11H,8-9H2,1H3,(H,24,25)
PDB

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n/an/a>1.00E+4n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with either Nav 1.7 or with Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro auto...

US Patent US9346798 (2016)


BindingDB Entry DOI: 10.7270/Q24X56N2
More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))		BDBM231271
PNG
(US9346798, 18)
Show SMILES FC(F)(F)c1ccc(N2CCNc3cc(ccc23)S(=O)(=O)Nc2ncns2)c(Cl)c1
Show InChI InChI=1S/C17H13ClF3N5O2S2/c18-12-7-10(17(19,20)21)1-3-14(12)26-6-5-22-13-8-11(2-4-15(13)26)30(27,28)25-16-23-9-24-29-16/h1-4,7-9,22H,5-6H2,(H,23,24,25)
PDB

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n/an/a>1.00E+4n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with either Nav 1.7 or with Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro auto...

US Patent US9346798 (2016)


BindingDB Entry DOI: 10.7270/Q24X56N2
More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))		BDBM231275
PNG
(US9346798, 22)
Show SMILES CN1CCC(=CC1)c1cc(ccc1N1CCOc2cc(ccc12)S(=O)(=O)Nc1ncns1)C(F)(F)F |c:4|
Show InChI InChI=1S/C23H22F3N5O3S2/c1-30-8-6-15(7-9-30)18-12-16(23(24,25)26)2-4-19(18)31-10-11-34-21-13-17(3-5-20(21)31)36(32,33)29-22-27-14-28-35-22/h2-6,12-14H,7-11H2,1H3,(H,27,28,29)
PDB

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n/an/a>1.00E+4n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with either Nav 1.7 or with Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro auto...

US Patent US9346798 (2016)


BindingDB Entry DOI: 10.7270/Q24X56N2
More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))		BDBM231282
PNG
(US9346798, 29)
Show SMILES Nc1cc(ccn1)-c1cc(ccc1N1CCOc2cc(ccc12)S(=O)(=O)Nc1ncns1)C(F)(F)F
Show InChI InChI=1S/C22H17F3N6O3S2/c23-22(24,25)14-1-3-17(16(10-14)13-5-6-27-20(26)9-13)31-7-8-34-19-11-15(2-4-18(19)31)36(32,33)30-21-28-12-29-35-21/h1-6,9-12H,7-8H2,(H2,26,27)(H,28,29,30)
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n/an/a 634n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with either Nav 1.7 or with Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro auto...

US Patent US9346798 (2016)


BindingDB Entry DOI: 10.7270/Q24X56N2
More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))		BDBM231288
PNG
(US9346798, 35)
Show SMILES FC(F)(F)Oc1cccc(c1)N1CCOc2cc(ccc12)S(=O)(=O)Nc1ncns1
Show InChI InChI=1S/C17H13F3N4O4S2/c18-17(19,20)28-12-3-1-2-11(8-12)24-6-7-27-15-9-13(4-5-14(15)24)30(25,26)23-16-21-10-22-29-16/h1-5,8-10H,6-7H2,(H,21,22,23)
PDB

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n/an/a>1.00E+4n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with either Nav 1.7 or with Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro auto...

US Patent US9346798 (2016)


BindingDB Entry DOI: 10.7270/Q24X56N2
More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))		BDBM231291
PNG
(US9346798, 38)
Show SMILES FC(F)(F)c1ccc(N2CCOc3cc(ccc23)S(=O)(=O)Nc2nccs2)c(c1)C1=CCNCC1 |t:33|
Show InChI InChI=1S/C23H21F3N4O3S2/c24-23(25,26)16-1-3-19(18(13-16)15-5-7-27-8-6-15)30-10-11-33-21-14-17(2-4-20(21)30)35(31,32)29-22-28-9-12-34-22/h1-5,9,12-14,27H,6-8,10-11H2,(H,28,29)
PDB

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n/an/a 254n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with either Nav 1.7 or with Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro auto...

US Patent US9346798 (2016)


BindingDB Entry DOI: 10.7270/Q24X56N2
More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))		BDBM231295
PNG
(US9346798, 42)
Show SMILES Cn1nccc1-c1cc(ccc1N1CCOc2cc(ccc12)S(=O)(=O)Nc1nccs1)C(F)(F)F
Show InChI InChI=1S/C22H18F3N5O3S2/c1-29-17(6-7-27-29)16-12-14(22(23,24)25)2-4-18(16)30-9-10-33-20-13-15(3-5-19(20)30)35(31,32)28-21-26-8-11-34-21/h2-8,11-13H,9-10H2,1H3,(H,26,28)
PDB

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n/an/a>1.00E+4n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with either Nav 1.7 or with Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro auto...

US Patent US9346798 (2016)


BindingDB Entry DOI: 10.7270/Q24X56N2
More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))		BDBM231309
PNG
(US9346798, 56)
Show SMILES Clc1ccc(N2CCOc3cc(ccc23)S(=O)(=O)Nc2nccs2)c(c1)C#N
Show InChI InChI=1S/C18H13ClN4O3S2/c19-13-1-3-15(12(9-13)11-20)23-6-7-26-17-10-14(2-4-16(17)23)28(24,25)22-18-21-5-8-27-18/h1-5,8-10H,6-7H2,(H,21,22)
PDB

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n/an/a 4.79E+3n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with either Nav 1.7 or with Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro auto...

US Patent US9346798 (2016)


BindingDB Entry DOI: 10.7270/Q24X56N2
More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))		BDBM231318
PNG
(US9346798, 65)
Show SMILES [N-]=[N+]=Nc1ccc(N2CCOc3cc(ccc23)S(=O)(=O)Nc2nccs2)c(c1)C1=CCNCC1 |t:32|
Show InChI InChI=1S/C22H21N7O3S2/c23-28-26-16-1-3-19(18(13-16)15-5-7-24-8-6-15)29-10-11-32-21-14-17(2-4-20(21)29)34(30,31)27-22-25-9-12-33-22/h1-5,9,12-14,24H,6-8,10-11H2,(H,25,27)
PDB

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n/an/a 5.28E+3n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with either Nav 1.7 or with Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro auto...

US Patent US9346798 (2016)


BindingDB Entry DOI: 10.7270/Q24X56N2
More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))		BDBM231320
PNG
(US9346798, 67)
Show SMILES Cc1ccc(Cl)c(c1)N1CCOc2cc(ccc12)S(=O)(=O)Nc1nccs1
Show InChI InChI=1S/C18H16ClN3O3S2/c1-12-2-4-14(19)16(10-12)22-7-8-25-17-11-13(3-5-15(17)22)27(23,24)21-18-20-6-9-26-18/h2-6,9-11H,7-8H2,1H3,(H,20,21)
PDB

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n/an/a 5.33E+3n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with either Nav 1.7 or with Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro auto...

US Patent US9346798 (2016)


BindingDB Entry DOI: 10.7270/Q24X56N2
More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))		BDBM231324
PNG
(US9346798, 71)
Show SMILES O=S(=O)(Nc1nccs1)c1ccc2N(CCOc2c1)c1ccc2ncsc2c1
Show InChI InChI=1S/C18H14N4O3S3/c23-28(24,21-18-19-5-8-26-18)13-2-4-15-16(10-13)25-7-6-22(15)12-1-3-14-17(9-12)27-11-20-14/h1-5,8-11H,6-7H2,(H,19,21)
PDB

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n/an/a>1.00E+4n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with either Nav 1.7 or with Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro auto...

US Patent US9346798 (2016)


BindingDB Entry DOI: 10.7270/Q24X56N2
More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))		BDBM231326
PNG
(US9346798, 73)
Show SMILES Cc1ccc2cnccc2c1N1CCOc2cc(ccc12)S(=O)(=O)Nc1nccs1
Show InChI InChI=1S/C21H18N4O3S2/c1-14-2-3-15-13-22-7-6-17(15)20(14)25-9-10-28-19-12-16(4-5-18(19)25)30(26,27)24-21-23-8-11-29-21/h2-8,11-13H,9-10H2,1H3,(H,23,24)
PDB

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n/an/a>1.00E+4n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with either Nav 1.7 or with Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro auto...

US Patent US9346798 (2016)


BindingDB Entry DOI: 10.7270/Q24X56N2
More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))		BDBM231334
PNG
(US9346798, 81)
Show SMILES Cc1cc(ccc1F)N1CCOc2cc(ccc12)S(=O)(=O)Nc1nccs1
Show InChI InChI=1S/C18H16FN3O3S2/c1-12-10-13(2-4-15(12)19)22-7-8-25-17-11-14(3-5-16(17)22)27(23,24)21-18-20-6-9-26-18/h2-6,9-11H,7-8H2,1H3,(H,20,21)
PDB

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n/an/a>1.00E+4n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with either Nav 1.7 or with Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro auto...

US Patent US9346798 (2016)


BindingDB Entry DOI: 10.7270/Q24X56N2
More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))		BDBM231347
PNG
(US9346798, 94)
Show SMILES C[C@H]1CN(c2ccc(cc2O1)S(=O)(=O)Nc1nccs1)c1ccc(cc1C#N)C(F)(F)F |r|
Show InChI InChI=1S/C20H15F3N4O3S2/c1-12-11-27(16-4-2-14(20(21,22)23)8-13(16)10-24)17-5-3-15(9-18(17)30-12)32(28,29)26-19-25-6-7-31-19/h2-9,12H,11H2,1H3,(H,25,26)/t12-/m0/s1
PDB

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n/an/a 724n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with either Nav 1.7 or with Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro auto...

US Patent US9346798 (2016)


BindingDB Entry DOI: 10.7270/Q24X56N2
More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))		BDBM231353
PNG
(US9346798, 100 | US9346798, 102)
Show SMILES CCC1CN(c2ccc(cc2O1)S(=O)(=O)Nc1nccs1)c1ccc(cc1C#N)C(F)(F)F
Show InChI InChI=1S/C21H17F3N4O3S2/c1-2-15-12-28(17-5-3-14(21(22,23)24)9-13(17)11-25)18-6-4-16(10-19(18)31-15)33(29,30)27-20-26-7-8-32-20/h3-10,15H,2,12H2,1H3,(H,26,27)
PDB

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n/an/a>1.00E+4n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with either Nav 1.7 or with Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro auto...

US Patent US9346798 (2016)


BindingDB Entry DOI: 10.7270/Q24X56N2
More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))		BDBM231363
PNG
(US9346798, 110)
Show SMILES Cc1cc(F)cnc1N1CCOc2cc(ccc12)S(=O)(=O)Nc1nccs1
Show InChI InChI=1S/C17H15FN4O3S2/c1-11-8-12(18)10-20-16(11)22-5-6-25-15-9-13(2-3-14(15)22)27(23,24)21-17-19-4-7-26-17/h2-4,7-10H,5-6H2,1H3,(H,19,21)
PDB

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n/an/a>1.00E+4n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with either Nav 1.7 or with Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro auto...

US Patent US9346798 (2016)


BindingDB Entry DOI: 10.7270/Q24X56N2
More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))		BDBM231367
PNG
(US9346798, 114)
Show SMILES COc1ccc(cc1N1CCOc2cc(ccc12)S(=O)(=O)Nc1nccs1)C(F)(F)F
Show InChI InChI=1S/C19H16F3N3O4S2/c1-28-16-5-2-12(19(20,21)22)10-15(16)25-7-8-29-17-11-13(3-4-14(17)25)31(26,27)24-18-23-6-9-30-18/h2-6,9-11H,7-8H2,1H3,(H,23,24)
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US Patent
n/an/a 5.06E+3n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with either Nav 1.7 or with Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro auto...

US Patent US9346798 (2016)


BindingDB Entry DOI: 10.7270/Q24X56N2
More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))		BDBM231371
PNG
(US9346798, 118)
Show SMILES COc1ccc(cc1C#N)N1CCOc2cc(ccc12)S(=O)(=O)Nc1nccs1
Show InChI InChI=1S/C19H16N4O4S2/c1-26-17-5-2-14(10-13(17)12-20)23-7-8-27-18-11-15(3-4-16(18)23)29(24,25)22-19-21-6-9-28-19/h2-6,9-11H,7-8H2,1H3,(H,21,22)
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n/an/a>1.00E+4n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with either Nav 1.7 or with Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro auto...

US Patent US9346798 (2016)


BindingDB Entry DOI: 10.7270/Q24X56N2
More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))		BDBM231386
PNG
(US9346798, 133)
Show SMILES Cc1cncc(C)c1N1CCOc2cc(ccc12)S(=O)(=O)Nc1nccs1
Show InChI InChI=1S/C18H18N4O3S2/c1-12-10-19-11-13(2)17(12)22-6-7-25-16-9-14(3-4-15(16)22)27(23,24)21-18-20-5-8-26-18/h3-5,8-11H,6-7H2,1-2H3,(H,20,21)
PDB

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n/an/a>1.00E+4n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with either Nav 1.7 or with Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro auto...

US Patent US9346798 (2016)


BindingDB Entry DOI: 10.7270/Q24X56N2
More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))		BDBM231397
PNG
(US9346798, 144)
Show SMILES COc1cnc(N2CCOc3cc(ccc23)S(=O)(=O)Nc2nccs2)c(OC)c1
Show InChI InChI=1S/C18H18N4O5S2/c1-25-12-9-16(26-2)17(20-11-12)22-6-7-27-15-10-13(3-4-14(15)22)29(23,24)21-18-19-5-8-28-18/h3-5,8-11H,6-7H2,1-2H3,(H,19,21)
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n/an/a>1.00E+4n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with either Nav 1.7 or with Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro auto...

US Patent US9346798 (2016)


BindingDB Entry DOI: 10.7270/Q24X56N2
More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))		BDBM231398
PNG
(US9346798, 145)
Show SMILES COc1ncc(cc1N1CCOc2cc(ccc12)S(=O)(=O)Nc1nccs1)C(F)(F)F
Show InChI InChI=1S/C18H15F3N4O4S2/c1-28-16-14(8-11(10-23-16)18(19,20)21)25-5-6-29-15-9-12(2-3-13(15)25)31(26,27)24-17-22-4-7-30-17/h2-4,7-10H,5-6H2,1H3,(H,22,24)
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n/an/a 7.38E+3n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with either Nav 1.7 or with Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro auto...

US Patent US9346798 (2016)


BindingDB Entry DOI: 10.7270/Q24X56N2
More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))		BDBM231422
PNG
(US9346798, 169)
Show SMILES Cc1c(Cl)cccc1N1CCOc2cc(ccc12)S(=O)(=O)Nc1nccs1
Show InChI InChI=1S/C18H16ClN3O3S2/c1-12-14(19)3-2-4-15(12)22-8-9-25-17-11-13(5-6-16(17)22)27(23,24)21-18-20-7-10-26-18/h2-7,10-11H,8-9H2,1H3,(H,20,21)
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n/an/a>1.00E+4n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with either Nav 1.7 or with Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro auto...

US Patent US9346798 (2016)


BindingDB Entry DOI: 10.7270/Q24X56N2
More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))		BDBM231426
PNG
(US9346798, 173)
Show SMILES FC(F)(F)c1cccc(c1)N1CCOc2cc(ccc12)S(=O)(=O)Nc1nccs1
Show InChI InChI=1S/C18H14F3N3O3S2/c19-18(20,21)12-2-1-3-13(10-12)24-7-8-27-16-11-14(4-5-15(16)24)29(25,26)23-17-22-6-9-28-17/h1-6,9-11H,7-8H2,(H,22,23)
PDB

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n/an/a>1.00E+4n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with either Nav 1.7 or with Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro auto...

US Patent US9346798 (2016)


BindingDB Entry DOI: 10.7270/Q24X56N2
More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))		BDBM231429
PNG
(US9346798, 176)
Show SMILES Fc1ccc(N2CCOc3cc(ccc23)S(=O)(=O)Nc2nccs2)c(F)c1
Show InChI InChI=1S/C17H13F2N3O3S2/c18-11-1-3-14(13(19)9-11)22-6-7-25-16-10-12(2-4-15(16)22)27(23,24)21-17-20-5-8-26-17/h1-5,8-10H,6-7H2,(H,20,21)
PDB

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n/an/a>1.00E+4n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with either Nav 1.7 or with Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro auto...

US Patent US9346798 (2016)


BindingDB Entry DOI: 10.7270/Q24X56N2
More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))		BDBM231433
PNG
(US9346798, 180)
Show SMILES Clc1ccc(Cl)c(c1)N1CCOc2cc(ccc12)S(=O)(=O)Nc1nccs1
Show InChI InChI=1S/C17H13Cl2N3O3S2/c18-11-1-3-13(19)15(9-11)22-6-7-25-16-10-12(2-4-14(16)22)27(23,24)21-17-20-5-8-26-17/h1-5,8-10H,6-7H2,(H,20,21)
PDB

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n/an/a 6.94E+3n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with either Nav 1.7 or with Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro auto...

US Patent US9346798 (2016)


BindingDB Entry DOI: 10.7270/Q24X56N2
More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))		BDBM231434
PNG
(US9346798, 181)
Show SMILES COc1cc(ccc1N1CCOc2cc(ccc12)S(=O)(=O)Nc1nccs1)C#N
Show InChI InChI=1S/C19H16N4O4S2/c1-26-17-10-13(12-20)2-4-15(17)23-7-8-27-18-11-14(3-5-16(18)23)29(24,25)22-19-21-6-9-28-19/h2-6,9-11H,7-8H2,1H3,(H,21,22)
PDB

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n/an/a>1.00E+4n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with either Nav 1.7 or with Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro auto...

US Patent US9346798 (2016)


BindingDB Entry DOI: 10.7270/Q24X56N2
More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))		BDBM231442
PNG
(US9346798, 189)
Show SMILES COc1ccc(C#N)c(c1)N1CCOc2cc(ccc12)S(=O)(=O)Nc1nccs1
Show InChI InChI=1S/C19H16N4O4S2/c1-26-14-3-2-13(12-20)17(10-14)23-7-8-27-18-11-15(4-5-16(18)23)29(24,25)22-19-21-6-9-28-19/h2-6,9-11H,7-8H2,1H3,(H,21,22)
PDB

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n/an/a 7.59E+3n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with either Nav 1.7 or with Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro auto...

US Patent US9346798 (2016)


BindingDB Entry DOI: 10.7270/Q24X56N2
More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))		BDBM231447
PNG
(US9346798, 194)
Show SMILES Cc1ccc(C#N)c(c1)N1CCOc2cc(ccc12)S(=O)(=O)Nc1nccs1
Show InChI InChI=1S/C19H16N4O3S2/c1-13-2-3-14(12-20)17(10-13)23-7-8-26-18-11-15(4-5-16(18)23)28(24,25)22-19-21-6-9-27-19/h2-6,9-11H,7-8H2,1H3,(H,21,22)
PDB

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n/an/a 3.59E+3n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with either Nav 1.7 or with Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro auto...

US Patent US9346798 (2016)


BindingDB Entry DOI: 10.7270/Q24X56N2
More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))		BDBM231458
PNG
(US9346798, 205)
Show SMILES COc1ccccc1N1CCOc2cc(ccc12)S(=O)(=O)Nc1nccs1
Show InChI InChI=1S/C18H17N3O4S2/c1-24-16-5-3-2-4-14(16)21-9-10-25-17-12-13(6-7-15(17)21)27(22,23)20-18-19-8-11-26-18/h2-8,11-12H,9-10H2,1H3,(H,19,20)
PDB

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n/an/a>1.00E+4n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with either Nav 1.7 or with Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro auto...

US Patent US9346798 (2016)


BindingDB Entry DOI: 10.7270/Q24X56N2
More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))		BDBM231464
PNG
(US9346798, 211)
Show SMILES OCCc1cc(ccc1N1CCOc2cc(ccc12)S(=O)(=O)Nc1nccs1)C(F)(F)F
Show InChI InChI=1S/C20H18F3N3O4S2/c21-20(22,23)14-1-3-16(13(11-14)5-8-27)26-7-9-30-18-12-15(2-4-17(18)26)32(28,29)25-19-24-6-10-31-19/h1-4,6,10-12,27H,5,7-9H2,(H,24,25)
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n/an/a 471n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with either Nav 1.7 or with Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro auto...

US Patent US9346798 (2016)


BindingDB Entry DOI: 10.7270/Q24X56N2
More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))		BDBM231467
PNG
(US9346798, 214)
Show SMILES COc1nc(ccc1N1CCOc2cc(ccc12)S(=O)(=O)Nc1nccs1)C(F)(F)F
Show InChI InChI=1S/C18H15F3N4O4S2/c1-28-16-13(4-5-15(23-16)18(19,20)21)25-7-8-29-14-10-11(2-3-12(14)25)31(26,27)24-17-22-6-9-30-17/h2-6,9-10H,7-8H2,1H3,(H,22,24)
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n/an/a>1.00E+4n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with either Nav 1.7 or with Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro auto...

US Patent US9346798 (2016)


BindingDB Entry DOI: 10.7270/Q24X56N2
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))		BDBM231261
PNG
(US9346798, 8)
Show SMILES NCc1nsc(NS(=O)(=O)c2ccc3N(CCOc3c2)c2ccc(cc2Cl)C(F)(F)F)n1
Show InChI InChI=1S/C18H15ClF3N5O3S2/c19-12-7-10(18(20,21)22)1-3-13(12)27-5-6-30-15-8-11(2-4-14(15)27)32(28,29)26-17-24-16(9-23)25-31-17/h1-4,7-8H,5-6,9,23H2,(H,24,25,26)
PDB

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n/an/a 7.58E+3n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with either Nav 1.7 or with Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro auto...

US Patent US9346798 (2016)


BindingDB Entry DOI: 10.7270/Q24X56N2
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))		BDBM231266
PNG
(US9346798, 13)
Show SMILES FC(F)(F)c1ccc(N2CCOc3cc(ccc23)S(=O)(=O)Nc2ccon2)c(Cl)c1
Show InChI InChI=1S/C18H13ClF3N3O4S/c19-13-9-11(18(20,21)22)1-3-14(13)25-6-8-28-16-10-12(2-4-15(16)25)30(26,27)24-17-5-7-29-23-17/h1-5,7,9-10H,6,8H2,(H,23,24)
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n/an/a 1.72E+3n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with either Nav 1.7 or with Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro auto...

US Patent US9346798 (2016)


BindingDB Entry DOI: 10.7270/Q24X56N2
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))		BDBM231293
PNG
(US9346798, 40)
Show SMILES Clc1ccc(cc1)N1CCOc2cc(ccc12)S(=O)(=O)Nc1nccs1
Show InChI InChI=1S/C17H14ClN3O3S2/c18-12-1-3-13(4-2-12)21-8-9-24-16-11-14(5-6-15(16)21)26(22,23)20-17-19-7-10-25-17/h1-7,10-11H,8-9H2,(H,19,20)
PDB

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n/an/a 713n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with either Nav 1.7 or with Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro auto...

US Patent US9346798 (2016)


BindingDB Entry DOI: 10.7270/Q24X56N2
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))		BDBM231294
PNG
(US9346798, 41)
Show SMILES Clc1cccc(c1)N1CCOc2cc(ccc12)S(=O)(=O)Nc1nccs1
Show InChI InChI=1S/C17H14ClN3O3S2/c18-12-2-1-3-13(10-12)21-7-8-24-16-11-14(4-5-15(16)21)26(22,23)20-17-19-6-9-25-17/h1-6,9-11H,7-8H2,(H,19,20)
PDB

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n/an/a 111n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with either Nav 1.7 or with Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro auto...

US Patent US9346798 (2016)


BindingDB Entry DOI: 10.7270/Q24X56N2
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))		BDBM231302
PNG
(US9346798, 49)
Show SMILES FC(F)(F)c1ccc(N2CCOc3cc(ccc23)S(=O)(=O)Nc2nccs2)c(c1)C#N
Show InChI InChI=1S/C19H13F3N4O3S2/c20-19(21,22)13-1-3-15(12(9-13)11-23)26-6-7-29-17-10-14(2-4-16(17)26)31(27,28)25-18-24-5-8-30-18/h1-5,8-10H,6-7H2,(H,24,25)
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n/an/a 15n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with either Nav 1.7 or with Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro auto...

US Patent US9346798 (2016)


BindingDB Entry DOI: 10.7270/Q24X56N2
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))		BDBM231311
PNG
(US9346798, 58)
Show SMILES O=S(=O)(Nc1nccs1)c1ccc2N(CCOc2c1)c1ccccc1C#N
Show InChI InChI=1S/C18H14N4O3S2/c19-12-13-3-1-2-4-15(13)22-8-9-25-17-11-14(5-6-16(17)22)27(23,24)21-18-20-7-10-26-18/h1-7,10-11H,8-9H2,(H,20,21)
PDB

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n/an/a 225n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with either Nav 1.7 or with Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro auto...

US Patent US9346798 (2016)


BindingDB Entry DOI: 10.7270/Q24X56N2
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))		BDBM231318
PNG
(US9346798, 65)
Show SMILES [N-]=[N+]=Nc1ccc(N2CCOc3cc(ccc23)S(=O)(=O)Nc2nccs2)c(c1)C1=CCNCC1 |t:32|
Show InChI InChI=1S/C22H21N7O3S2/c23-28-26-16-1-3-19(18(13-16)15-5-7-24-8-6-15)29-10-11-32-21-14-17(2-4-20(21)29)34(30,31)27-22-25-9-12-33-22/h1-5,9,12-14,24H,6-8,10-11H2,(H,25,27)
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n/an/a 24n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with either Nav 1.7 or with Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro auto...

US Patent US9346798 (2016)


BindingDB Entry DOI: 10.7270/Q24X56N2
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))		BDBM231320
PNG
(US9346798, 67)
Show SMILES Cc1ccc(Cl)c(c1)N1CCOc2cc(ccc12)S(=O)(=O)Nc1nccs1
Show InChI InChI=1S/C18H16ClN3O3S2/c1-12-2-4-14(19)16(10-12)22-7-8-25-17-11-13(3-5-15(17)22)27(23,24)21-18-20-6-9-26-18/h2-6,9-11H,7-8H2,1H3,(H,20,21)
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n/an/a 381n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with either Nav 1.7 or with Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro auto...

US Patent US9346798 (2016)


BindingDB Entry DOI: 10.7270/Q24X56N2
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))		BDBM231324
PNG
(US9346798, 71)
Show SMILES O=S(=O)(Nc1nccs1)c1ccc2N(CCOc2c1)c1ccc2ncsc2c1
Show InChI InChI=1S/C18H14N4O3S3/c23-28(24,21-18-19-5-8-26-18)13-2-4-15-16(10-13)25-7-6-22(15)12-1-3-14-17(9-12)27-11-20-14/h1-5,8-11H,6-7H2,(H,19,21)
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n/an/a 605n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with either Nav 1.7 or with Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro auto...

US Patent US9346798 (2016)


BindingDB Entry DOI: 10.7270/Q24X56N2
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))		BDBM231326
PNG
(US9346798, 73)
Show SMILES Cc1ccc2cnccc2c1N1CCOc2cc(ccc12)S(=O)(=O)Nc1nccs1
Show InChI InChI=1S/C21H18N4O3S2/c1-14-2-3-15-13-22-7-6-17(15)20(14)25-9-10-28-19-12-16(4-5-18(19)25)30(26,27)24-21-23-8-11-29-21/h2-8,11-13H,9-10H2,1H3,(H,23,24)
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n/an/a 7.58E+3n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with either Nav 1.7 or with Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro auto...

US Patent US9346798 (2016)


BindingDB Entry DOI: 10.7270/Q24X56N2
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))		BDBM231340
PNG
(US9346798, 87)
Show SMILES FC(F)(F)c1ccc(N2CCOc3cc(ccc23)S(=O)(=O)Nc2cccnn2)c(c1)C1=CCNCC1 |t:34|
Show InChI InChI=1S/C24H22F3N5O3S/c25-24(26,27)17-3-5-20(19(14-17)16-7-10-28-11-8-16)32-12-13-35-22-15-18(4-6-21(22)32)36(33,34)31-23-2-1-9-29-30-23/h1-7,9,14-15,28H,8,10-13H2,(H,30,31)
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n/an/a 26n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with either Nav 1.7 or with Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro auto...

US Patent US9346798 (2016)


BindingDB Entry DOI: 10.7270/Q24X56N2
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))		BDBM231352
PNG
(US9346798, 99)
Show SMILES FC(F)(F)c1cnc(N2CCOc3cc(ccc23)S(=O)(=O)Nc2ccncn2)c(Cl)c1
Show InChI InChI=1S/C18H13ClF3N5O3S/c19-13-7-11(18(20,21)22)9-24-17(13)27-5-6-30-15-8-12(1-2-14(15)27)31(28,29)26-16-3-4-23-10-25-16/h1-4,7-10H,5-6H2,(H,23,25,26)
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n/an/a 327n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with either Nav 1.7 or with Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro auto...

US Patent US9346798 (2016)


BindingDB Entry DOI: 10.7270/Q24X56N2
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))		BDBM231356
PNG
(US9346798, 103)
Show SMILES COc1cc(Cl)cnc1N1CC(C)Oc2cc(ccc12)S(=O)(=O)Nc1nccs1
Show InChI InChI=1S/C18H17ClN4O4S2/c1-11-10-23(17-16(26-2)7-12(19)9-21-17)14-4-3-13(8-15(14)27-11)29(24,25)22-18-20-5-6-28-18/h3-9,11H,10H2,1-2H3,(H,20,22)
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n/an/a 40n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with either Nav 1.7 or with Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro auto...

US Patent US9346798 (2016)


BindingDB Entry DOI: 10.7270/Q24X56N2
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))		BDBM231358
PNG
(US9346798, 105)
Show SMILES COc1cc(Cl)ccc1N1C[C@@H](C)Oc2cc(ccc12)S(=O)(=O)Nc1nccs1 |r|
Show InChI InChI=1S/C19H18ClN3O4S2/c1-12-11-23(15-5-3-13(20)9-17(15)26-2)16-6-4-14(10-18(16)27-12)29(24,25)22-19-21-7-8-28-19/h3-10,12H,11H2,1-2H3,(H,21,22)/t12-/m1/s1
PDB

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n/an/a 53.5n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with either Nav 1.7 or with Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro auto...

US Patent US9346798 (2016)


BindingDB Entry DOI: 10.7270/Q24X56N2
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))		BDBM231371
PNG
(US9346798, 118)
Show SMILES COc1ccc(cc1C#N)N1CCOc2cc(ccc12)S(=O)(=O)Nc1nccs1
Show InChI InChI=1S/C19H16N4O4S2/c1-26-17-5-2-14(10-13(17)12-20)23-7-8-27-18-11-15(3-4-16(18)23)29(24,25)22-19-21-6-9-28-19/h2-6,9-11H,7-8H2,1H3,(H,21,22)
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n/an/a 660n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with either Nav 1.7 or with Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro auto...

US Patent US9346798 (2016)


BindingDB Entry DOI: 10.7270/Q24X56N2
More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%