Found 11 hits Enzyme Inhibition Constant Data Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Glutamate receptor
(127/144 = 88%)† (RABBIT) | BDBM50002369
((2S-(2alpha,3beta,4beta))-2-carboxy-4-(1-methyleth...)Show SMILES CC(=C)[C@H]1CN[C@@H]([C@H]1CC(O)=O)C(O)=O |r| Show InChI InChI=1S/C10H15NO4/c1-5(2)7-4-11-9(10(14)15)6(7)3-8(12)13/h6-7,9,11H,1,3-4H2,2H3,(H,12,13)(H,14,15)/t6-,7+,9-/m0/s1 | PDB
UniProtKB/TrEMBL
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| PDB Article PubMed
| 1.41 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Bristol
Curated by PDSP Ki Database
| |
Neuropharmacology 36: 1483-8 (1997)
Article DOI: 10.1016/s0028-3908(97)00161-5 BindingDB Entry DOI: 10.7270/Q2C827T6 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Glutamate receptor ionotropic, kainate 2
(140/144 = 97%)† (Rattus norvegicus) | BDBM50002369
((2S-(2alpha,3beta,4beta))-2-carboxy-4-(1-methyleth...)Show SMILES CC(=C)[C@H]1CN[C@@H]([C@H]1CC(O)=O)C(O)=O |r| Show InChI InChI=1S/C10H15NO4/c1-5(2)7-4-11-9(10(14)15)6(7)3-8(12)13/h6-7,9,11H,1,3-4H2,2H3,(H,12,13)(H,14,15)/t6-,7+,9-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
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| MMDB PDB Article PubMed
| 3.70 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Eli Lilly and Company
Curated by ChEMBL
| Assay Description Inhibition of [3H]-kainate binding at rat forebrain ionotropic glutamate receptor kainate 2 |
J Med Chem 39: 3617-24 (1996)
Article DOI: 10.1021/jm960155a BindingDB Entry DOI: 10.7270/Q2WW7GRZ |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Glutamate receptor ionotropic, kainate 2
(140/144 = 97%)† (Rattus norvegicus) | BDBM50002369
((2S-(2alpha,3beta,4beta))-2-carboxy-4-(1-methyleth...)Show SMILES CC(=C)[C@H]1CN[C@@H]([C@H]1CC(O)=O)C(O)=O |r| Show InChI InChI=1S/C10H15NO4/c1-5(2)7-4-11-9(10(14)15)6(7)3-8(12)13/h6-7,9,11H,1,3-4H2,2H3,(H,12,13)(H,14,15)/t6-,7+,9-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
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| MMDB PDB Article PubMed
| 12.7 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
European Research Centre for Drug Discovery and Development (NatSynDrugs)
Curated by ChEMBL
| Assay Description Displacement of [3H]kainic acid from rat recombinant iGluR6(V,C,R) receptor expressed in Sf9 cells |
J Med Chem 51: 6614-8 (2008)
Article DOI: 10.1021/jm800865a BindingDB Entry DOI: 10.7270/Q261117R |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Glutamate receptor ionotropic, kainate 2
(140/144 = 97%)† (Rattus norvegicus) | BDBM50002369
((2S-(2alpha,3beta,4beta))-2-carboxy-4-(1-methyleth...)Show SMILES CC(=C)[C@H]1CN[C@@H]([C@H]1CC(O)=O)C(O)=O |r| Show InChI InChI=1S/C10H15NO4/c1-5(2)7-4-11-9(10(14)15)6(7)3-8(12)13/h6-7,9,11H,1,3-4H2,2H3,(H,12,13)(H,14,15)/t6-,7+,9-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
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| MMDB PDB Article PubMed
| 12.7 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universite Blaise Pascal
Curated by ChEMBL
| Assay Description Displacement of [3H]SYM2081 from rat recombinant iGluR6 |
J Med Chem 51: 4093-103 (2008)
Article DOI: 10.1021/jm800092x BindingDB Entry DOI: 10.7270/Q20V8DP6 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Glutamate receptor ionotropic, kainate 2
(140/144 = 97%)† (Homo sapiens (Human)) | BDBM50002369
((2S-(2alpha,3beta,4beta))-2-carboxy-4-(1-methyleth...)Show SMILES CC(=C)[C@H]1CN[C@@H]([C@H]1CC(O)=O)C(O)=O |r| Show InChI InChI=1S/C10H15NO4/c1-5(2)7-4-11-9(10(14)15)6(7)3-8(12)13/h6-7,9,11H,1,3-4H2,2H3,(H,12,13)(H,14,15)/t6-,7+,9-/m0/s1 | PDB
UniProtKB/SwissProt
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| PDB PubMed
| 32 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Eli Lilly and Company Ltd
Curated by ChEMBL
| Assay Description Binding affinity of compound was determined against Ionotropic glutamate receptor ionotropic kainate 2 using cell membranes prepared from HEK293 cell... |
Bioorg Med Chem Lett 10: 1807-10 (2000)
BindingDB Entry DOI: 10.7270/Q2765FVB |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Glutamate receptor ionotropic, kainate 2
(140/144 = 97%)† (Homo sapiens (Human)) | BDBM50002369
((2S-(2alpha,3beta,4beta))-2-carboxy-4-(1-methyleth...)Show SMILES CC(=C)[C@H]1CN[C@@H]([C@H]1CC(O)=O)C(O)=O |r| Show InChI InChI=1S/C10H15NO4/c1-5(2)7-4-11-9(10(14)15)6(7)3-8(12)13/h6-7,9,11H,1,3-4H2,2H3,(H,12,13)(H,14,15)/t6-,7+,9-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
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| PDB PubMed
| 32 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly, S.A.
Curated by ChEMBL
| Assay Description Binding affinity against human ionotropic glutamate receptor ionotropic kainate 2 in HEK293 cells using [3H]-kainate as radioligand |
J Med Chem 43: 1958-68 (2000)
BindingDB Entry DOI: 10.7270/Q2FX78QB |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Glutamate receptor ionotropic, kainate 2
(140/144 = 97%)† (Homo sapiens (Human)) | BDBM50002369
((2S-(2alpha,3beta,4beta))-2-carboxy-4-(1-methyleth...)Show SMILES CC(=C)[C@H]1CN[C@@H]([C@H]1CC(O)=O)C(O)=O |r| Show InChI InChI=1S/C10H15NO4/c1-5(2)7-4-11-9(10(14)15)6(7)3-8(12)13/h6-7,9,11H,1,3-4H2,2H3,(H,12,13)(H,14,15)/t6-,7+,9-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
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| PDB Article PubMed
| 53 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Eli Lilly and Company
Curated by ChEMBL
| Assay Description Inhibition of [3H]-kainate binding at ionotropic glutamate receptor kainate 2 |
J Med Chem 39: 3617-24 (1996)
Article DOI: 10.1021/jm960155a BindingDB Entry DOI: 10.7270/Q2WW7GRZ |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Glutamate receptor ionotropic, kainate 2
(140/144 = 97%)† (Rattus norvegicus) | BDBM50002369
((2S-(2alpha,3beta,4beta))-2-carboxy-4-(1-methyleth...)Show SMILES CC(=C)[C@H]1CN[C@@H]([C@H]1CC(O)=O)C(O)=O |r| Show InChI InChI=1S/C10H15NO4/c1-5(2)7-4-11-9(10(14)15)6(7)3-8(12)13/h6-7,9,11H,1,3-4H2,2H3,(H,12,13)(H,14,15)/t6-,7+,9-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
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| MMDB PDB Article PubMed
| n/a | n/a | n/a | 39 | n/a | n/a | n/a | n/a | n/a |
University Walk
Curated by ChEMBL
| Assay Description Displacement of [3H]kainate from rat GLUK6 receptor expressed in HEK293 cells |
J Med Chem 48: 7867-81 (2005)
Article DOI: 10.1021/jm050584l BindingDB Entry DOI: 10.7270/Q2V69KCT |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Glutamate receptor ionotropic, kainate 2
(140/144 = 97%)† (Homo sapiens (Human)) | BDBM50002369
((2S-(2alpha,3beta,4beta))-2-carboxy-4-(1-methyleth...)Show SMILES CC(=C)[C@H]1CN[C@@H]([C@H]1CC(O)=O)C(O)=O |r| Show InChI InChI=1S/C10H15NO4/c1-5(2)7-4-11-9(10(14)15)6(7)3-8(12)13/h6-7,9,11H,1,3-4H2,2H3,(H,12,13)(H,14,15)/t6-,7+,9-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
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CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem
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| PDB PubMed
| n/a | n/a | n/a | n/a | 700 | n/a | n/a | n/a | n/a |
Lilly, S.A.
Curated by ChEMBL
| Assay Description Effective concentration against human GluR6 expressed in HEK293 cells |
J Med Chem 43: 1958-68 (2000)
BindingDB Entry DOI: 10.7270/Q2FX78QB |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Glutamate receptor ionotropic, kainate 2
(140/144 = 97%)† (Rattus norvegicus) | BDBM50002369
((2S-(2alpha,3beta,4beta))-2-carboxy-4-(1-methyleth...)Show SMILES CC(=C)[C@H]1CN[C@@H]([C@H]1CC(O)=O)C(O)=O |r| Show InChI InChI=1S/C10H15NO4/c1-5(2)7-4-11-9(10(14)15)6(7)3-8(12)13/h6-7,9,11H,1,3-4H2,2H3,(H,12,13)(H,14,15)/t6-,7+,9-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
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CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem
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| MMDB PDB Article PubMed
| n/a | n/a | n/a | n/a | 1.80E+3 | n/a | n/a | n/a | n/a |
University of Copenhagen
Curated by ChEMBL
| Assay Description Agonist activity at rat recombinant GluR6(Q) RNA-edited isoform expressed in HEK293 cells assessed as increase in intracellular calcium level by Fluo... |
J Med Chem 52: 4911-22 (2009)
Checked by Author Article DOI: 10.1021/jm900565c BindingDB Entry DOI: 10.7270/Q2R49RP9 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Glutamate receptor ionotropic, kainate 2
(140/144 = 97%)† (Homo sapiens (Human)) | BDBM50002369
((2S-(2alpha,3beta,4beta))-2-carboxy-4-(1-methyleth...)Show SMILES CC(=C)[C@H]1CN[C@@H]([C@H]1CC(O)=O)C(O)=O |r| Show InChI InChI=1S/C10H15NO4/c1-5(2)7-4-11-9(10(14)15)6(7)3-8(12)13/h6-7,9,11H,1,3-4H2,2H3,(H,12,13)(H,14,15)/t6-,7+,9-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
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CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem
Patents
Similars
| PDB PubMed
| n/a | n/a | n/a | n/a | 700 | n/a | n/a | n/a | n/a |
Eli Lilly and Company Ltd
Curated by ChEMBL
| Assay Description Compound was tested for agonistic activity at Glutamate receptor 6 using HEK293 cells |
Bioorg Med Chem Lett 10: 1807-10 (2000)
BindingDB Entry DOI: 10.7270/Q2765FVB |
More data for this Ligand-Target Pair | 3D Structure (crystal) |