Found 8 hits Enzyme Inhibition Constant Data Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Hepatocyte growth factor receptor
(308/312 = 99%)† (Homo sapiens (Human)) | BDBM60589
![PNG](/data/jpeg/tenK6/BindingDB_60589.png) (6-{[6-(1-methyl-1H-pyrazol-4-yl)-[1,2,4]triazolo[4...)Show InChI InChI=1S/C18H13N7S/c1-24-11-13(10-20-24)16-6-7-17-21-22-18(25(17)23-16)26-14-4-5-15-12(9-14)3-2-8-19-15/h2-11H,1H3 | PDB MMDB
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UniProtKB/SwissProt
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DrugBank MCE PC cid PC sid PDB UniChem
Similars
| PDB Article PubMed
| n/a | n/a | 3.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Southeast University
Curated by ChEMBL
| Assay Description Inhibition of c-Met (unknown origin) incubated for 1 hr by spectrophotometric analysis |
Bioorg Med Chem 24: 3483-93 (2016)
Article DOI: 10.1016/j.bmc.2016.05.057 BindingDB Entry DOI: 10.7270/Q29G5PQT |
More data for this Ligand-Target Pair | ![3D 3D](/images/Docked_3d.png) 3D Structure (crystal) |
Hepatocyte growth factor receptor
(308/312 = 99%)† (Homo sapiens (Human)) | BDBM60589
![PNG](/data/jpeg/tenK6/BindingDB_60589.png) (6-{[6-(1-methyl-1H-pyrazol-4-yl)-[1,2,4]triazolo[4...)Show InChI InChI=1S/C18H13N7S/c1-24-11-13(10-20-24)16-6-7-17-21-22-18(25(17)23-16)26-14-4-5-15-12(9-14)3-2-8-19-15/h2-11H,1H3 | PDB MMDB
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UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
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DrugBank MCE PC cid PC sid PDB UniChem
Similars
| PDB Article PubMed
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Shenyang Pharmaceutical University
Curated by ChEMBL
| Assay Description Inhibition of c-Met (unknown origin) |
Eur J Med Chem 108: 495-504 (2016)
Article DOI: 10.1016/j.ejmech.2015.12.016 BindingDB Entry DOI: 10.7270/Q2G73GMC |
More data for this Ligand-Target Pair | ![3D 3D](/images/Docked_3d.png) 3D Structure (crystal) |
Isoform 2 of Hepatocyte growth factor receptor (2)
(308/312 = 99%)† (Homo sapiens (Human)) | BDBM60589
![PNG](/data/jpeg/tenK6/BindingDB_60589.png) (6-{[6-(1-methyl-1H-pyrazol-4-yl)-[1,2,4]triazolo[4...)Show InChI InChI=1S/C18H13N7S/c1-24-11-13(10-20-24)16-6-7-17-21-22-18(25(17)23-16)26-14-4-5-15-12(9-14)3-2-8-19-15/h2-11H,1H3 | PDB
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
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DrugBank MCE PC cid PC sid PDB UniChem
Similars
| PDB Article PubMed
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | 7.0 | 25 |
Tianjin University of Science and Technology
| Assay Description The c-Met kinase activity of five target compounds and three positive compounds were evaluated using standard Z-LYTE Assays (fluorescence resonance e... |
Bioorg Chem 65: 146-58 (2016)
Article DOI: 10.1016/j.bioorg.2016.02.009 BindingDB Entry DOI: 10.7270/Q2VT1QVX |
More data for this Ligand-Target Pair | ![3D 3D](/images/Docked_3d.png) 3D Structure (crystal) |
Hepatocyte growth factor receptor
(308/312 = 99%)† (Homo sapiens (Human)) | BDBM60589
![PNG](/data/jpeg/tenK6/BindingDB_60589.png) (6-{[6-(1-methyl-1H-pyrazol-4-yl)-[1,2,4]triazolo[4...)Show InChI InChI=1S/C18H13N7S/c1-24-11-13(10-20-24)16-6-7-17-21-22-18(25(17)23-16)26-14-4-5-15-12(9-14)3-2-8-19-15/h2-11H,1H3 | PDB MMDB
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UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
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DrugBank MCE PC cid PC sid PDB UniChem
Similars
| PDB Article PubMed
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Institute of Materia Medica
Curated by ChEMBL
| Assay Description Inhibition of C-Met (unknown origin) using polu (Glu,Tyr)4:1 substrate after 30 mins incubation by multi-well spectrophotometry |
ACS Med Chem Lett 6: 507-12 (2015)
Article DOI: 10.1021/ml5004876 BindingDB Entry DOI: 10.7270/Q2QV3P79 |
More data for this Ligand-Target Pair | ![3D 3D](/images/Docked_3d.png) 3D Structure (crystal) |
Hepatocyte growth factor receptor
(308/312 = 99%)† (Homo sapiens (Human)) | BDBM60589
![PNG](/data/jpeg/tenK6/BindingDB_60589.png) (6-{[6-(1-methyl-1H-pyrazol-4-yl)-[1,2,4]triazolo[4...)Show InChI InChI=1S/C18H13N7S/c1-24-11-13(10-20-24)16-6-7-17-21-22-18(25(17)23-16)26-14-4-5-15-12(9-14)3-2-8-19-15/h2-11H,1H3 | PDB MMDB
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DrugBank MCE PC cid PC sid PDB UniChem
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| PDB US Patent
| n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis AG
US Patent
| Assay Description The kinase assay is based on the LanthaScreen technology. LanthaScreen is the detection of Time-Resolved Fluorescence Resonance Energy Transfer (TR-F... |
US Patent US9062045 (2015)
BindingDB Entry DOI: 10.7270/Q23F4NDS |
More data for this Ligand-Target Pair | ![3D 3D](/images/Docked_3d.png) 3D Structure (crystal) |
Hepatocyte growth factor receptor
(308/312 = 99%)† (Homo sapiens (Human)) | BDBM60589
![PNG](/data/jpeg/tenK6/BindingDB_60589.png) (6-{[6-(1-methyl-1H-pyrazol-4-yl)-[1,2,4]triazolo[4...)Show InChI InChI=1S/C18H13N7S/c1-24-11-13(10-20-24)16-6-7-17-21-22-18(25(17)23-16)26-14-4-5-15-12(9-14)3-2-8-19-15/h2-11H,1H3 | PDB MMDB
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UniProtKB/SwissProt
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DrugBank MCE PC cid PC sid PDB UniChem
Similars
| PDB Article PubMed
| n/a | n/a | n/a | 3.90 | n/a | n/a | n/a | n/a | n/a |
Ambit Biosciences
Curated by ChEMBL
| Assay Description Binding constant for MET(M1250T) kinase domain |
Nat Biotechnol 29: 1046-51 (2011)
Article DOI: 10.1038/nbt.1990 BindingDB Entry DOI: 10.7270/Q25D8S70 |
More data for this Ligand-Target Pair | ![3D 3D](/images/Docked_3d.png) 3D Structure (crystal) |
Hepatocyte growth factor receptor
(308/312 = 99%)† (Homo sapiens (Human)) | BDBM60589
![PNG](/data/jpeg/tenK6/BindingDB_60589.png) (6-{[6-(1-methyl-1H-pyrazol-4-yl)-[1,2,4]triazolo[4...)Show InChI InChI=1S/C18H13N7S/c1-24-11-13(10-20-24)16-6-7-17-21-22-18(25(17)23-16)26-14-4-5-15-12(9-14)3-2-8-19-15/h2-11H,1H3 | PDB MMDB
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UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
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DrugBank MCE PC cid PC sid PDB UniChem
Similars
| PDB Article PubMed
| n/a | n/a | n/a | 0.190 | n/a | n/a | n/a | n/a | n/a |
Ambit Biosciences
Curated by ChEMBL
| Assay Description Binding constant for MET kinase domain |
Nat Biotechnol 29: 1046-51 (2011)
Article DOI: 10.1038/nbt.1990 BindingDB Entry DOI: 10.7270/Q25D8S70 |
More data for this Ligand-Target Pair | ![3D 3D](/images/Docked_3d.png) 3D Structure (crystal) |
Hepatocyte growth factor receptor
(308/312 = 99%)† (Homo sapiens (Human)) | BDBM60589
![PNG](/data/jpeg/tenK6/BindingDB_60589.png) (6-{[6-(1-methyl-1H-pyrazol-4-yl)-[1,2,4]triazolo[4...)Show InChI InChI=1S/C18H13N7S/c1-24-11-13(10-20-24)16-6-7-17-21-22-18(25(17)23-16)26-14-4-5-15-12(9-14)3-2-8-19-15/h2-11H,1H3 | PDB MMDB
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UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| Purchase
DrugBank MCE PC cid PC sid PDB UniChem
Similars
| PDB Article PubMed
| n/a | n/a | n/a | 0.820 | n/a | n/a | n/a | n/a | n/a |
Ambit Biosciences
Curated by ChEMBL
| Assay Description Binding constant for MET(M1250T) kinase domain |
Nat Biotechnol 29: 1046-51 (2011)
Article DOI: 10.1038/nbt.1990 BindingDB Entry DOI: 10.7270/Q25D8S70 |
More data for this Ligand-Target Pair | ![3D 3D](/images/Docked_3d.png) 3D Structure (crystal) |