Affinity Data by PubMed id=10425095

PubMed code 10425095

Found 26 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Vesicular acetylcholine transporter (Homo sapiens (Human))	BDBM50039604 ((+)-1''-(3-Iodo-benzyl)-4-phenyl-[1,3'']bipiperidi...) Show SMILES Show InChI	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	0.130	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Minnesota Curated by ChEMBL					Assay Description Displacement of [3H]vesamicol from Vesicular Acetylcholine Transporter (VAChT)				J Med Chem 42: 2862-9 (1999) Article DOI: 10.1021/jm980560x BindingDB Entry DOI: 10.7270/Q2542MS2
University of Minnesota Curated by ChEMBL					More data for this Ligand-Target Pair
Vesicular acetylcholine transporter (Homo sapiens (Human))	BDBM50079277 ((4aR,6R,7R,8aR)-1-(3-Iodo-benzyl)-7-(4-phenyl-pipe...) Show SMILES Show InChI	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	0.260	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Minnesota Curated by ChEMBL					Assay Description Displacement of [3H]vesamicol from Vesicular Acetylcholine Transporter (VAChT)				J Med Chem 42: 2862-9 (1999) Article DOI: 10.1021/jm980560x BindingDB Entry DOI: 10.7270/Q2542MS2
University of Minnesota Curated by ChEMBL					More data for this Ligand-Target Pair
Vesicular acetylcholine transporter (Homo sapiens (Human))	BDBM50079275 (CHEMBL97524 \| [(4aR,6R,7R,8aR)-6-Hydroxy-7-(4-phen...) Show SMILES Show InChI	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	0.300	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Minnesota Curated by ChEMBL					Assay Description Displacement of [3H]vesamicol from Vesicular Acetylcholine Transporter (VAChT)				J Med Chem 42: 2862-9 (1999) Article DOI: 10.1021/jm980560x BindingDB Entry DOI: 10.7270/Q2542MS2
University of Minnesota Curated by ChEMBL					More data for this Ligand-Target Pair
Vesicular acetylcholine transporter (Homo sapiens (Human))	BDBM50079278 ((4aR,6R,7R,8aR)-1-((E)-3-Iodo-allyl)-7-(4-phenyl-p...) Show SMILES Show InChI	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	0.400	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Minnesota Curated by ChEMBL					Assay Description Displacement of [3H]vesamicol from Vesicular Acetylcholine Transporter (VAChT)				J Med Chem 42: 2862-9 (1999) Article DOI: 10.1021/jm980560x BindingDB Entry DOI: 10.7270/Q2542MS2
University of Minnesota Curated by ChEMBL					More data for this Ligand-Target Pair
Vesicular acetylcholine transporter (Homo sapiens (Human))	BDBM50079276 ((4aR,6R,7R,8aR)-7-(4-Phenyl-piperidin-1-yl)-decahy...) Show SMILES Show InChI	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	0.440	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Minnesota Curated by ChEMBL					Assay Description Displacement of [3H]vesamicol from Vesicular Acetylcholine Transporter (VAChT)				J Med Chem 42: 2862-9 (1999) Article DOI: 10.1021/jm980560x BindingDB Entry DOI: 10.7270/Q2542MS2
University of Minnesota Curated by ChEMBL					More data for this Ligand-Target Pair
Vesicular acetylcholine transporter (Homo sapiens (Human))	BDBM50079274 ((4aR,6R,7R,8aR)-1-(4-Fluoro-benzyl)-7-(4-phenyl-pi...) Show SMILES Show InChI	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	0.990	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Minnesota Curated by ChEMBL					Assay Description Displacement of [3H]vesamicol from Vesicular Acetylcholine Transporter (VAChT)				J Med Chem 42: 2862-9 (1999) Article DOI: 10.1021/jm980560x BindingDB Entry DOI: 10.7270/Q2542MS2
University of Minnesota Curated by ChEMBL					More data for this Ligand-Target Pair
Vesicular acetylcholine transporter (Homo sapiens (Human))	BDBM50018094 ((1R,2R)-2-(4-Phenyl-piperidin-1-yl)-cyclohexanol \|...) Show SMILES Show InChI	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	2	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Minnesota Curated by ChEMBL					Assay Description Displacement of [3H]vesamicol from Vesicular Acetylcholine Transporter (VAChT)				J Med Chem 42: 2862-9 (1999) Article DOI: 10.1021/jm980560x BindingDB Entry DOI: 10.7270/Q2542MS2
University of Minnesota Curated by ChEMBL					More data for this Ligand-Target Pair
Vesicular acetylcholine transporter (Homo sapiens (Human))	BDBM50079280 ((4aR,6R,7R,8aR)-1-(3-Iodo-benzyl)-6-(4-phenyl-pipe...) Show SMILES Show InChI	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	5.20	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Minnesota Curated by ChEMBL					Assay Description Displacement of [3H]vesamicol from Vesicular Acetylcholine Transporter (VAChT)				J Med Chem 42: 2862-9 (1999) Article DOI: 10.1021/jm980560x BindingDB Entry DOI: 10.7270/Q2542MS2
University of Minnesota Curated by ChEMBL					More data for this Ligand-Target Pair
Vesicular acetylcholine transporter (Homo sapiens (Human))	BDBM50079279 ((4aR,6R,7R,8aR)-1-(4-Fluoro-benzyl)-6-(4-phenyl-pi...) Show SMILES Show InChI	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Minnesota Curated by ChEMBL					Assay Description Displacement of [3H]vesamicol from Vesicular Acetylcholine Transporter (VAChT)				J Med Chem 42: 2862-9 (1999) Article DOI: 10.1021/jm980560x BindingDB Entry DOI: 10.7270/Q2542MS2
University of Minnesota Curated by ChEMBL					More data for this Ligand-Target Pair
Sigma non-opioid intracellular receptor 1 (Homo sapiens (Human))	BDBM50079274 ((4aR,6R,7R,8aR)-1-(4-Fluoro-benzyl)-7-(4-phenyl-pi...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	21	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Minnesota Curated by ChEMBL					Assay Description Binding affinity against Sigma opioid receptor type 1 in guinea pig brain membranes using [3H](+)-pentazocine as radioligand				J Med Chem 42: 2862-9 (1999) Article DOI: 10.1021/jm980560x BindingDB Entry DOI: 10.7270/Q2542MS2
University of Minnesota Curated by ChEMBL					More data for this Ligand-Target Pair
Sigma non-opioid intracellular receptor 1 (Homo sapiens (Human))	BDBM50018094 ((1R,2R)-2-(4-Phenyl-piperidin-1-yl)-cyclohexanol \|...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	26	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Minnesota Curated by ChEMBL					Assay Description Binding affinity against Sigma opioid receptor type 1 in guinea pig brain membranes using [3H](+)-pentazocine as radioligand				J Med Chem 42: 2862-9 (1999) Article DOI: 10.1021/jm980560x BindingDB Entry DOI: 10.7270/Q2542MS2
University of Minnesota Curated by ChEMBL					More data for this Ligand-Target Pair
Sigma non-opioid intracellular receptor 1 (RAT)	BDBM50018094 ((1R,2R)-2-(4-Phenyl-piperidin-1-yl)-cyclohexanol \|...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	34	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Minnesota Curated by ChEMBL					Assay Description Binding affinity against Sigma opioid receptor type 2 in rat liver membranes using [3H]DTG (DuPont-NEN) as radioligand in the presence of (+)-pentazo...				J Med Chem 42: 2862-9 (1999) Article DOI: 10.1021/jm980560x BindingDB Entry DOI: 10.7270/Q2542MS2
University of Minnesota Curated by ChEMBL					More data for this Ligand-Target Pair
Sigma non-opioid intracellular receptor 1 (Homo sapiens (Human))	BDBM50039604 ((+)-1''-(3-Iodo-benzyl)-4-phenyl-[1,3'']bipiperidi...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	92	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Minnesota Curated by ChEMBL					Assay Description Binding affinity against Sigma opioid receptor type 1 in guinea pig brain membranes using [3H](+)-pentazocine as radioligand				J Med Chem 42: 2862-9 (1999) Article DOI: 10.1021/jm980560x BindingDB Entry DOI: 10.7270/Q2542MS2
University of Minnesota Curated by ChEMBL					More data for this Ligand-Target Pair
Sigma non-opioid intracellular receptor 1 (Homo sapiens (Human))	BDBM50079275 (CHEMBL97524 \| [(4aR,6R,7R,8aR)-6-Hydroxy-7-(4-phen...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	110	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Minnesota Curated by ChEMBL					Assay Description Binding affinity against Sigma opioid receptor type 1 in guinea pig brain membranes using [3H](+)-pentazocine as radioligand				J Med Chem 42: 2862-9 (1999) Article DOI: 10.1021/jm980560x BindingDB Entry DOI: 10.7270/Q2542MS2
University of Minnesota Curated by ChEMBL					More data for this Ligand-Target Pair
Sigma non-opioid intracellular receptor 1 (Homo sapiens (Human))	BDBM50079275 (CHEMBL97524 \| [(4aR,6R,7R,8aR)-6-Hydroxy-7-(4-phen...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	110	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Minnesota Curated by ChEMBL					Assay Description Binding affinity against Sigma opioid receptor type 1 in guinea pig brain membranes using [3H](+)-pentazocine as radioligand				J Med Chem 42: 2862-9 (1999) Article DOI: 10.1021/jm980560x BindingDB Entry DOI: 10.7270/Q2542MS2
University of Minnesota Curated by ChEMBL					More data for this Ligand-Target Pair
Sigma non-opioid intracellular receptor 1 (Homo sapiens (Human))	BDBM50079278 ((4aR,6R,7R,8aR)-1-((E)-3-Iodo-allyl)-7-(4-phenyl-p...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	125	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Minnesota Curated by ChEMBL					Assay Description Binding affinity against Sigma opioid receptor type 1 in guinea pig brain membranes using [3H](+)-pentazocine as radioligand				J Med Chem 42: 2862-9 (1999) Article DOI: 10.1021/jm980560x BindingDB Entry DOI: 10.7270/Q2542MS2
University of Minnesota Curated by ChEMBL					More data for this Ligand-Target Pair
Sigma non-opioid intracellular receptor 1 (RAT)	BDBM50079274 ((4aR,6R,7R,8aR)-1-(4-Fluoro-benzyl)-7-(4-phenyl-pi...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	127	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Minnesota Curated by ChEMBL					Assay Description Binding affinity against Sigma opioid receptor type 2 in rat liver membranes using [3H]DTG (DuPont-NEN) as radioligand in the presence of (+)-pentazo...				J Med Chem 42: 2862-9 (1999) Article DOI: 10.1021/jm980560x BindingDB Entry DOI: 10.7270/Q2542MS2
University of Minnesota Curated by ChEMBL					More data for this Ligand-Target Pair
Sigma non-opioid intracellular receptor 1 (RAT)	BDBM50039604 ((+)-1''-(3-Iodo-benzyl)-4-phenyl-[1,3'']bipiperidi...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	190	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Minnesota Curated by ChEMBL					Assay Description Binding affinity against Sigma opioid receptor type 2 in rat liver membranes using [3H]DTG (DuPont-NEN) as radioligand in the presence of (+)-pentazo...				J Med Chem 42: 2862-9 (1999) Article DOI: 10.1021/jm980560x BindingDB Entry DOI: 10.7270/Q2542MS2
University of Minnesota Curated by ChEMBL					More data for this Ligand-Target Pair
Sigma non-opioid intracellular receptor 1 (RAT)	BDBM50079275 (CHEMBL97524 \| [(4aR,6R,7R,8aR)-6-Hydroxy-7-(4-phen...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	233	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Minnesota Curated by ChEMBL					Assay Description Binding affinity against Sigma opioid receptor type 2 in rat liver membranes using [3H]DTG (DuPont-NEN) as radioligand in the presence of (+)-pentazo...				J Med Chem 42: 2862-9 (1999) Article DOI: 10.1021/jm980560x BindingDB Entry DOI: 10.7270/Q2542MS2
University of Minnesota Curated by ChEMBL					More data for this Ligand-Target Pair
Sigma non-opioid intracellular receptor 1 (RAT)	BDBM50079275 (CHEMBL97524 \| [(4aR,6R,7R,8aR)-6-Hydroxy-7-(4-phen...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	233	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Minnesota Curated by ChEMBL					Assay Description Binding affinity against Sigma opioid receptor type 2 in rat liver membranes using [3H]DTG (DuPont-NEN) as radioligand in the presence of (+)-pentazo...				J Med Chem 42: 2862-9 (1999) Article DOI: 10.1021/jm980560x BindingDB Entry DOI: 10.7270/Q2542MS2
University of Minnesota Curated by ChEMBL					More data for this Ligand-Target Pair
Sigma non-opioid intracellular receptor 1 (RAT)	BDBM50079278 ((4aR,6R,7R,8aR)-1-((E)-3-Iodo-allyl)-7-(4-phenyl-p...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	363	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Minnesota Curated by ChEMBL					Assay Description Binding affinity against Sigma opioid receptor type 2 in rat liver membranes using [3H]DTG (DuPont-NEN) as radioligand in the presence of (+)-pentazo...				J Med Chem 42: 2862-9 (1999) Article DOI: 10.1021/jm980560x BindingDB Entry DOI: 10.7270/Q2542MS2
University of Minnesota Curated by ChEMBL					More data for this Ligand-Target Pair
Sigma non-opioid intracellular receptor 1 (RAT)	BDBM50079276 ((4aR,6R,7R,8aR)-7-(4-Phenyl-piperidin-1-yl)-decahy...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Minnesota Curated by ChEMBL					Assay Description Binding affinity against Sigma opioid receptor type 2 in rat liver membranes using [3H]DTG (DuPont-NEN) as radioligand in the presence of (+)-pentazo...				J Med Chem 42: 2862-9 (1999) Article DOI: 10.1021/jm980560x BindingDB Entry DOI: 10.7270/Q2542MS2
University of Minnesota Curated by ChEMBL					More data for this Ligand-Target Pair
Sigma non-opioid intracellular receptor 1 (RAT)	BDBM50079276 ((4aR,6R,7R,8aR)-7-(4-Phenyl-piperidin-1-yl)-decahy...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Minnesota Curated by ChEMBL					Assay Description Binding affinity against Sigma opioid receptor type 2 in rat liver membranes using [3H]DTG (DuPont-NEN) as radioligand in the presence of (+)-pentazo...				J Med Chem 42: 2862-9 (1999) Article DOI: 10.1021/jm980560x BindingDB Entry DOI: 10.7270/Q2542MS2
University of Minnesota Curated by ChEMBL					More data for this Ligand-Target Pair
Sigma non-opioid intracellular receptor 1 (Homo sapiens (Human))	BDBM50079276 ((4aR,6R,7R,8aR)-7-(4-Phenyl-piperidin-1-yl)-decahy...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>2.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Minnesota Curated by ChEMBL					Assay Description Binding affinity against Sigma opioid receptor type 1 in guinea pig brain membranes using [3H](+)-pentazocine as radioligand				J Med Chem 42: 2862-9 (1999) Article DOI: 10.1021/jm980560x BindingDB Entry DOI: 10.7270/Q2542MS2
University of Minnesota Curated by ChEMBL					More data for this Ligand-Target Pair
Sigma non-opioid intracellular receptor 1 (Homo sapiens (Human))	BDBM50079276 ((4aR,6R,7R,8aR)-7-(4-Phenyl-piperidin-1-yl)-decahy...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>2.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Minnesota Curated by ChEMBL					Assay Description Binding affinity against Sigma opioid receptor type 1 in guinea pig brain membranes using [3H](+)-pentazocine as radioligand				J Med Chem 42: 2862-9 (1999) Article DOI: 10.1021/jm980560x BindingDB Entry DOI: 10.7270/Q2542MS2
University of Minnesota Curated by ChEMBL					More data for this Ligand-Target Pair
Vesicular acetylcholine transporter (Homo sapiens (Human))	BDBM50046961 ((3'R,4'R)-4-Phenyl-[1,3']bipiperidinyl-4'-ol \| CHE...) Show SMILES O[C@@H]1CCNC[C@H]1N1CCC(CC1)c1ccccc1 Show InChI	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	2.90E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Minnesota Curated by ChEMBL					Assay Description Displacement of [3H]vesamicol from Vesicular Acetylcholine Transporter (VAChT)				J Med Chem 42: 2862-9 (1999) Article DOI: 10.1021/jm980560x BindingDB Entry DOI: 10.7270/Q2542MS2
University of Minnesota Curated by ChEMBL					More data for this Ligand-Target Pair

* indicates data uncertainty>20%