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PubMed code 10476875

Compile data set for download or QSAR
Found 36 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM50029559
PNG
(2-[3-tert-Butylsulfanyl-1-(4-chloro-benzyl)-5-(qui...)
Show SMILES CC(C)(C)Sc1c(CC(C)(C)C(O)=O)n(Cc2ccc(Cl)cc2)c2ccc(OCc3ccc4ccccc4n3)cc12
Show InChI InChI=1S/C34H35ClN2O3S/c1-33(2,3)41-31-27-18-26(40-21-25-15-12-23-8-6-7-9-28(23)36-25)16-17-29(27)37(20-22-10-13-24(35)14-11-22)30(31)19-34(4,5)32(38)39/h6-18H,19-21H2,1-5H3,(H,38,39)
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n/an/a 2n/an/an/an/an/an/a



Merck Frosst Center for Therapeutic Research

Curated by ChEMBL


Assay Description
Measuring the affinity of leukotriene synthesis inhibitor for 5-lipoxygenase activating protein by using [125I]-L-691,831 as radioligand.

Bioorg Med Chem Lett 9: 2391-6 (1999)


BindingDB Entry DOI: 10.7270/Q26T0KTJ
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM50080255
PNG
(3-[5-(Benzothiazol-2-ylmethoxy)-3-tert-butylsulfan...)
Show SMILES CC(C)(C)Sc1c(CC(C)(C)C(O)=O)n(Cc2ccc(Cl)cc2)c2ccc(OCc3nc4ccccc4s3)cc12
Show InChI InChI=1S/C32H33ClN2O3S2/c1-31(2,3)40-29-23-16-22(38-19-28-34-24-8-6-7-9-27(24)39-28)14-15-25(23)35(18-20-10-12-21(33)13-11-20)26(29)17-32(4,5)30(36)37/h6-16H,17-19H2,1-5H3,(H,36,37)
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Merck Frosst Center for Therapeutic Research

Curated by ChEMBL


Assay Description
Measuring the affinity of leukotriene synthesis inhibitor for 5-lipoxygenase activating protein by using [125I]-L-691,831 as radioligand.

Bioorg Med Chem Lett 9: 2391-6 (1999)


BindingDB Entry DOI: 10.7270/Q26T0KTJ
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM50080243
PNG
(3-[3-tert-Butylsulfanyl-1-(4-chloro-benzyl)-5-([1,...)
Show SMILES CC(C)(C)Sc1c(CC(C)(C)C(O)=O)n(Cc2ccc(Cl)cc2)c2ccc(OCc3ccc4cnccc4n3)cc12
Show InChI InChI=1S/C33H34ClN3O3S/c1-32(2,3)41-30-26-16-25(40-20-24-11-8-22-18-35-15-14-27(22)36-24)12-13-28(26)37(19-21-6-9-23(34)10-7-21)29(30)17-33(4,5)31(38)39/h6-16,18H,17,19-20H2,1-5H3,(H,38,39)
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Merck Frosst Center for Therapeutic Research

Curated by ChEMBL


Assay Description
Measuring the affinity of leukotriene synthesis inhibitor for 5-lipoxygenase activating protein by using [125I]-L-691,831 as radioligand.

Bioorg Med Chem Lett 9: 2391-6 (1999)


BindingDB Entry DOI: 10.7270/Q26T0KTJ
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM50080233
PNG
(3-[3-tert-Butylsulfanyl-1-(4-chloro-benzyl)-5-(6-f...)
Show SMILES CC(C)(C)Sc1c(CC(C)(C)C(O)=O)n(Cc2ccc(Cl)cc2)c2ccc(OCc3ccc4cc(F)ccc4n3)cc12
Show InChI InChI=1S/C34H34ClFN2O3S/c1-33(2,3)42-31-27-17-26(41-20-25-12-8-22-16-24(36)11-14-28(22)37-25)13-15-29(27)38(19-21-6-9-23(35)10-7-21)30(31)18-34(4,5)32(39)40/h6-17H,18-20H2,1-5H3,(H,39,40)
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n/an/a 2n/an/an/an/an/an/a



Merck Frosst Center for Therapeutic Research

Curated by ChEMBL


Assay Description
Measuring the affinity of leukotriene synthesis inhibitor for 5-lipoxygenase activating protein by using [125I]-L-691,831 as radioligand.

Bioorg Med Chem Lett 9: 2391-6 (1999)


BindingDB Entry DOI: 10.7270/Q26T0KTJ
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM50080261
PNG
(3-[3-tert-Butylsulfanyl-1-(4-chloro-benzyl)-5-([1,...)
Show SMILES CC(C)(C)Sc1c(CC(C)(C)C(O)=O)n(Cc2ccc(Cl)cc2)c2ccc(OCc3ccc4cccnc4n3)cc12
Show InChI InChI=1S/C33H34ClN3O3S/c1-32(2,3)41-29-26-17-25(40-20-24-13-10-22-7-6-16-35-30(22)36-24)14-15-27(26)37(19-21-8-11-23(34)12-9-21)28(29)18-33(4,5)31(38)39/h6-17H,18-20H2,1-5H3,(H,38,39)
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Merck Frosst Center for Therapeutic Research

Curated by ChEMBL


Assay Description
Measuring the affinity of leukotriene synthesis inhibitor for 5-lipoxygenase activating protein by using [125I]-L-691,831 as radioligand.

Bioorg Med Chem Lett 9: 2391-6 (1999)


BindingDB Entry DOI: 10.7270/Q26T0KTJ
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM50080247
PNG
(3-[3-tert-Butylsulfanyl-1-(4-chloro-benzyl)-5-(2-m...)
Show SMILES Cc1nc(COc2ccc3n(Cc4ccc(Cl)cc4)c(CC(C)(C)C(O)=O)c(SC(C)(C)C)c3c2)cs1
Show InChI InChI=1S/C29H33ClN2O3S2/c1-18-31-21(17-36-18)16-35-22-11-12-24-23(13-22)26(37-28(2,3)4)25(14-29(5,6)27(33)34)32(24)15-19-7-9-20(30)10-8-19/h7-13,17H,14-16H2,1-6H3,(H,33,34)
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n/an/a 3n/an/an/an/an/an/a



Merck Frosst Center for Therapeutic Research

Curated by ChEMBL


Assay Description
Measuring the affinity of leukotriene synthesis inhibitor for 5-lipoxygenase activating protein by using [125I]-L-691,831 as radioligand.

Bioorg Med Chem Lett 9: 2391-6 (1999)


BindingDB Entry DOI: 10.7270/Q26T0KTJ
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM50080250
PNG
(3-(3-(tert-butylthio)-1-(4-chlorobenzyl)-5-(pyridi...)
Show SMILES CC(C)(C)Sc1c(CC(C)(C)C(O)=O)n(Cc2ccc(Cl)cc2)c2ccc(OCc3ccccn3)cc12
Show InChI InChI=1S/C30H33ClN2O3S/c1-29(2,3)37-27-24-16-23(36-19-22-8-6-7-15-32-22)13-14-25(24)33(18-20-9-11-21(31)12-10-20)26(27)17-30(4,5)28(34)35/h6-16H,17-19H2,1-5H3,(H,34,35)
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n/an/a 3n/an/an/an/an/an/a



Merck Frosst Center for Therapeutic Research

Curated by ChEMBL


Assay Description
Measuring the affinity of leukotriene synthesis inhibitor for 5-lipoxygenase activating protein by using [125I]-L-691,831 as radioligand.

Bioorg Med Chem Lett 9: 2391-6 (1999)


BindingDB Entry DOI: 10.7270/Q26T0KTJ
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM50080258
PNG
(3-[3-tert-Butylsulfanyl-1-(4-chloro-benzyl)-5-(thi...)
Show SMILES CC(C)(C)Sc1c(CC(C)(C)C(O)=O)n(Cc2ccc(Cl)cc2)c2ccc(OCc3cscn3)cc12
Show InChI InChI=1S/C28H31ClN2O3S2/c1-27(2,3)36-25-22-12-21(34-15-20-16-35-17-30-20)10-11-23(22)31(14-18-6-8-19(29)9-7-18)24(25)13-28(4,5)26(32)33/h6-12,16-17H,13-15H2,1-5H3,(H,32,33)
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n/an/a 5n/an/an/an/an/an/a



Merck Frosst Center for Therapeutic Research

Curated by ChEMBL


Assay Description
Measuring the affinity of leukotriene synthesis inhibitor for 5-lipoxygenase activating protein by using [125I]-L-691,831 as radioligand.

Bioorg Med Chem Lett 9: 2391-6 (1999)


BindingDB Entry DOI: 10.7270/Q26T0KTJ
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM50080248
PNG
(3-[5-(Benzooxazol-2-ylmethoxy)-3-tert-butylsulfany...)
Show SMILES CC(C)(C)Sc1c(CC(C)(C)C(O)=O)n(Cc2ccc(Cl)cc2)c2ccc(OCc3nc4ccccc4o3)cc12
Show InChI InChI=1S/C32H33ClN2O4S/c1-31(2,3)40-29-23-16-22(38-19-28-34-24-8-6-7-9-27(24)39-28)14-15-25(23)35(18-20-10-12-21(33)13-11-20)26(29)17-32(4,5)30(36)37/h6-16H,17-19H2,1-5H3,(H,36,37)
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n/an/a 5n/an/an/an/an/an/a



Merck Frosst Center for Therapeutic Research

Curated by ChEMBL


Assay Description
Measuring the affinity of leukotriene synthesis inhibitor for 5-lipoxygenase activating protein by using [125I]-L-691,831 as radioligand.

Bioorg Med Chem Lett 9: 2391-6 (1999)


BindingDB Entry DOI: 10.7270/Q26T0KTJ
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM50403715
PNG
(CHEMBL2114162)
Show SMILES C[C@@H](COc1ccc2n(Cc3ccc(Cl)cc3)c(CC(C)(C)C(O)=O)c(SC(C)(C)C)c2c1)c1ccccn1 |r|
Show InChI InChI=1S/C32H37ClN2O3S/c1-21(26-9-7-8-16-34-26)20-38-24-14-15-27-25(17-24)29(39-31(2,3)4)28(18-32(5,6)30(36)37)35(27)19-22-10-12-23(33)13-11-22/h7-17,21H,18-20H2,1-6H3,(H,36,37)/t21-/m0/s1
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Merck Frosst Center for Therapeutic Research

Curated by ChEMBL


Assay Description
Measuring the affinity of leukotriene synthesis inhibitor for 5-Lipoxygenase activating protein (FLAP) by using [125I]-L-691,831 as radioligand.

Bioorg Med Chem Lett 9: 2391-6 (1999)


BindingDB Entry DOI: 10.7270/Q26T0KTJ
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM50080251
PNG
(3-[3-tert-Butylsulfanyl-1-(4-chloro-benzyl)-5-(pyr...)
Show SMILES CC(C)(C)Sc1c(CC(C)(C)C(O)=O)n(Cc2ccc(Cl)cc2)c2ccc(OCc3cnccn3)cc12
Show InChI InChI=1S/C29H32ClN3O3S/c1-28(2,3)37-26-23-14-22(36-18-21-16-31-12-13-32-21)10-11-24(23)33(17-19-6-8-20(30)9-7-19)25(26)15-29(4,5)27(34)35/h6-14,16H,15,17-18H2,1-5H3,(H,34,35)
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n/an/a 7n/an/an/an/an/an/a



Merck Frosst Center for Therapeutic Research

Curated by ChEMBL


Assay Description
Measuring the affinity of leukotriene synthesis inhibitor for 5-lipoxygenase activating protein by using [125I]-L-691,831 as radioligand.

Bioorg Med Chem Lett 9: 2391-6 (1999)


BindingDB Entry DOI: 10.7270/Q26T0KTJ
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM50080249
PNG
(3-[3-tert-Butylsulfanyl-1-(4-chloro-benzyl)-5-(5,6...)
Show SMILES CC(C)(C)Sc1c(CC(C)(C)C(O)=O)n(Cc2ccc(Cl)cc2)c2ccc(OCc3ccc4CCCCc4n3)cc12
Show InChI InChI=1S/C34H39ClN2O3S/c1-33(2,3)41-31-27-18-26(40-21-25-15-12-23-8-6-7-9-28(23)36-25)16-17-29(27)37(20-22-10-13-24(35)14-11-22)30(31)19-34(4,5)32(38)39/h10-18H,6-9,19-21H2,1-5H3,(H,38,39)
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n/an/a 8n/an/an/an/an/an/a



Merck Frosst Center for Therapeutic Research

Curated by ChEMBL


Assay Description
Measuring the affinity of leukotriene synthesis inhibitor for 5-lipoxygenase activating protein by using [125I]-L-691,831 as radioligand.

Bioorg Med Chem Lett 9: 2391-6 (1999)


BindingDB Entry DOI: 10.7270/Q26T0KTJ
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM50080256
PNG
(3-[3-tert-Butylsulfanyl-1-(4-chloro-benzyl)-5-(6-c...)
Show SMILES CC(C)(C)Sc1c(CC(C)(C)C(O)=O)n(Cc2ccc(Cl)cc2)c2ccc(OCc3cccc(Cl)n3)cc12
Show InChI InChI=1S/C30H32Cl2N2O3S/c1-29(2,3)38-27-23-15-22(37-18-21-7-6-8-26(32)33-21)13-14-24(23)34(17-19-9-11-20(31)12-10-19)25(27)16-30(4,5)28(35)36/h6-15H,16-18H2,1-5H3,(H,35,36)
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n/an/a 8n/an/an/an/an/an/a



Merck Frosst Center for Therapeutic Research

Curated by ChEMBL


Assay Description
Measuring the affinity of leukotriene synthesis inhibitor for 5-lipoxygenase activating protein by using [125I]-L-691,831 as radioligand.

Bioorg Med Chem Lett 9: 2391-6 (1999)


BindingDB Entry DOI: 10.7270/Q26T0KTJ
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM50080238
PNG
(3-[3-tert-Butylsulfanyl-1-(4-chloro-benzyl)-5-(2-p...)
Show SMILES CC(COc1ccc2n(Cc3ccc(Cl)cc3)c(CC(C)(C)C(O)=O)c(SC(C)(C)C)c2c1)c1ccccn1
Show InChI InChI=1S/C32H37ClN2O3S/c1-21(26-9-7-8-16-34-26)20-38-24-14-15-27-25(17-24)29(39-31(2,3)4)28(18-32(5,6)30(36)37)35(27)19-22-10-12-23(33)13-11-22/h7-17,21H,18-20H2,1-6H3,(H,36,37)
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Merck Frosst Center for Therapeutic Research

Curated by ChEMBL


Assay Description
Measuring the affinity of leukotriene synthesis inhibitor for 5-lipoxygenase activating protein by using [125I]-L-691,831 as radioligand.

Bioorg Med Chem Lett 9: 2391-6 (1999)


BindingDB Entry DOI: 10.7270/Q26T0KTJ
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM50080254
PNG
(3-[3-tert-Butylsulfanyl-1-(4-chloro-benzyl)-5-(iso...)
Show SMILES CC(C)(C)Sc1c(CC(C)(C)C(O)=O)n(Cc2ccc(Cl)cc2)c2ccc(OCc3cc4ccccc4cn3)cc12
Show InChI InChI=1S/C34H35ClN2O3S/c1-33(2,3)41-31-28-17-27(40-21-26-16-23-8-6-7-9-24(23)19-36-26)14-15-29(28)37(20-22-10-12-25(35)13-11-22)30(31)18-34(4,5)32(38)39/h6-17,19H,18,20-21H2,1-5H3,(H,38,39)
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n/an/a 10n/an/an/an/an/an/a



Merck Frosst Center for Therapeutic Research

Curated by ChEMBL


Assay Description
Measuring the affinity of leukotriene synthesis inhibitor for 5-lipoxygenase activating protein by using [125I]-L-691,831 as radioligand.

Bioorg Med Chem Lett 9: 2391-6 (1999)


BindingDB Entry DOI: 10.7270/Q26T0KTJ
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM50080253
PNG
(3-[3-tert-Butylsulfanyl-1-(4-chloro-benzyl)-5-((E)...)
Show SMILES CC(C)(C)Sc1c(CC(C)(C)C(O)=O)n(Cc2ccc(Cl)cc2)c2ccc(\C=C\c3ccc4ccccc4n3)cc12
Show InChI InChI=1S/C35H35ClN2O2S/c1-34(2,3)41-32-28-20-23(12-17-27-18-14-25-8-6-7-9-29(25)37-27)13-19-30(28)38(22-24-10-15-26(36)16-11-24)31(32)21-35(4,5)33(39)40/h6-20H,21-22H2,1-5H3,(H,39,40)/b17-12+
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Merck Frosst Center for Therapeutic Research

Curated by ChEMBL


Assay Description
Measuring the affinity of leukotriene synthesis inhibitor for 5-lipoxygenase activating protein by using [125I]-L-691,831 as radioligand.

Bioorg Med Chem Lett 9: 2391-6 (1999)


BindingDB Entry DOI: 10.7270/Q26T0KTJ
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM50217046
PNG
(CHEMBL3350287)
Show SMILES C[C@H](COc1ccc2n(Cc3ccc(Cl)cc3)c(CC(C)(C)C(O)=O)c(SC(C)(C)C)c2c1)c1ccccn1 |r|
Show InChI InChI=1S/C32H37ClN2O3S/c1-21(26-9-7-8-16-34-26)20-38-24-14-15-27-25(17-24)29(39-31(2,3)4)28(18-32(5,6)30(36)37)35(27)19-22-10-12-23(33)13-11-22/h7-17,21H,18-20H2,1-6H3,(H,36,37)/t21-/m1/s1
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n/an/a 12n/an/an/an/an/an/a



Merck Frosst Center for Therapeutic Research

Curated by ChEMBL


Assay Description
Measuring the affinity of leukotriene synthesis inhibitor for 5-lipoxygenase activating protein by using [125I]-L-691,831 as radioligand.

Bioorg Med Chem Lett 9: 2391-6 (1999)


BindingDB Entry DOI: 10.7270/Q26T0KTJ
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM50080242
PNG
(3-[3-tert-Butylsulfanyl-1-(4-chloro-benzyl)-5-(4-i...)
Show SMILES CC(C)c1csc(COc2ccc3n(Cc4ccc(Cl)cc4)c(CC(C)(C)C(O)=O)c(SC(C)(C)C)c3c2)n1
Show InChI InChI=1S/C31H37ClN2O3S2/c1-19(2)24-18-38-27(33-24)17-37-22-12-13-25-23(14-22)28(39-30(3,4)5)26(15-31(6,7)29(35)36)34(25)16-20-8-10-21(32)11-9-20/h8-14,18-19H,15-17H2,1-7H3,(H,35,36)
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n/an/a 13n/an/an/an/an/an/a



Merck Frosst Center for Therapeutic Research

Curated by ChEMBL


Assay Description
Measuring the affinity of leukotriene synthesis inhibitor for 5-lipoxygenase activating protein by using [125I]-L-691,831 as radioligand.

Bioorg Med Chem Lett 9: 2391-6 (1999)


BindingDB Entry DOI: 10.7270/Q26T0KTJ
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM50080245
PNG
(3-[3-tert-Butylsulfanyl-1-(4-chloro-benzyl)-5-(6,7...)
Show SMILES CC(C)(C)Sc1c(CC(C)(C)C(O)=O)n(Cc2ccc(Cl)cc2)c2ccc(OCc3ccc4cc(F)c(F)cc4n3)cc12
Show InChI InChI=1S/C34H33ClF2N2O3S/c1-33(2,3)43-31-25-15-24(42-19-23-11-8-21-14-26(36)27(37)16-28(21)38-23)12-13-29(25)39(18-20-6-9-22(35)10-7-20)30(31)17-34(4,5)32(40)41/h6-16H,17-19H2,1-5H3,(H,40,41)
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n/an/a 14n/an/an/an/an/an/a



Merck Frosst Center for Therapeutic Research

Curated by ChEMBL


Assay Description
Measuring the affinity of leukotriene synthesis inhibitor for 5-lipoxygenase activating protein by using [125I]-L-691,831 as radioligand.

Bioorg Med Chem Lett 9: 2391-6 (1999)


BindingDB Entry DOI: 10.7270/Q26T0KTJ
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM50080240
PNG
(3-[3-tert-Butylsulfanyl-1-(4-chloro-benzyl)-5-(2-q...)
Show SMILES CC(C)(C)Sc1c(CC(C)(C)C(O)=O)n(Cc2ccc(Cl)cc2)c2ccc(CCc3ccc4ccccc4n3)cc12
Show InChI InChI=1S/C35H37ClN2O2S/c1-34(2,3)41-32-28-20-23(12-17-27-18-14-25-8-6-7-9-29(25)37-27)13-19-30(28)38(22-24-10-15-26(36)16-11-24)31(32)21-35(4,5)33(39)40/h6-11,13-16,18-20H,12,17,21-22H2,1-5H3,(H,39,40)
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n/an/a 16n/an/an/an/an/an/a



Merck Frosst Center for Therapeutic Research

Curated by ChEMBL


Assay Description
Measuring the affinity of leukotriene synthesis inhibitor for 5-lipoxygenase activating protein by using [125I]-L-691,831 as radioligand.

Bioorg Med Chem Lett 9: 2391-6 (1999)


BindingDB Entry DOI: 10.7270/Q26T0KTJ
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM50080241
PNG
((+)-3-[3-tert-Butylsulfanyl-1-(4-chloro-benzyl)-5-...)
Show SMILES CC(Oc1ccc2n(Cc3ccc(Cl)cc3)c(CC(C)(C)C(O)=O)c(SC(C)(C)C)c2c1)c1ccc2ccccc2n1
Show InChI InChI=1S/C35H37ClN2O3S/c1-22(28-17-13-24-9-7-8-10-29(24)37-28)41-26-16-18-30-27(19-26)32(42-34(2,3)4)31(20-35(5,6)33(39)40)38(30)21-23-11-14-25(36)15-12-23/h7-19,22H,20-21H2,1-6H3,(H,39,40)
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n/an/a 16n/an/an/an/an/an/a



Merck Frosst Center for Therapeutic Research

Curated by ChEMBL


Assay Description
Measuring the affinity of leukotriene synthesis inhibitor for 5-lipoxygenase activating protein by using [125I]-L-691,831 as radioligand.

Bioorg Med Chem Lett 9: 2391-6 (1999)


BindingDB Entry DOI: 10.7270/Q26T0KTJ
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM50080237
PNG
(3-[3-tert-Butylsulfanyl-1-(4-chloro-benzyl)-5-(qui...)
Show SMILES CC(C)(C)Sc1c(CC(C)(C)C(O)=O)n(Cc2ccc(Cl)cc2)c2ccc(COCc3ccc4ccccc4n3)cc12
Show InChI InChI=1S/C35H37ClN2O3S/c1-34(2,3)42-32-28-18-24(21-41-22-27-16-13-25-8-6-7-9-29(25)37-27)12-17-30(28)38(20-23-10-14-26(36)15-11-23)31(32)19-35(4,5)33(39)40/h6-18H,19-22H2,1-5H3,(H,39,40)
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n/an/a 26n/an/an/an/an/an/a



Merck Frosst Center for Therapeutic Research

Curated by ChEMBL


Assay Description
Measuring the affinity of leukotriene synthesis inhibitor for 5-lipoxygenase activating protein by using [125I]-L-691,831 as radioligand.

Bioorg Med Chem Lett 9: 2391-6 (1999)


BindingDB Entry DOI: 10.7270/Q26T0KTJ
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM50080236
PNG
(3-[3-tert-Butylsulfanyl-1-(4-chloro-benzyl)-5-(2-m...)
Show SMILES Cc1nc2ccc(COc3ccc4n(Cc5ccc(Cl)cc5)c(CC(C)(C)C(O)=O)c(SC(C)(C)C)c4c3)cc2s1
Show InChI InChI=1S/C33H35ClN2O3S2/c1-20-35-26-13-9-22(15-29(26)40-20)19-39-24-12-14-27-25(16-24)30(41-32(2,3)4)28(17-33(5,6)31(37)38)36(27)18-21-7-10-23(34)11-8-21/h7-16H,17-19H2,1-6H3,(H,37,38)
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n/an/a 40n/an/an/an/an/an/a



Merck Frosst Center for Therapeutic Research

Curated by ChEMBL


Assay Description
Measuring the affinity of leukotriene synthesis inhibitor for 5-lipoxygenase activating protein by using [125I]-L-691,831 as radioligand.

Bioorg Med Chem Lett 9: 2391-6 (1999)


BindingDB Entry DOI: 10.7270/Q26T0KTJ
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM50080252
PNG
(3-[3-tert-Butylsulfanyl-1-(4-chloro-benzyl)-5-(pyr...)
Show SMILES CC(C)(C)Sc1c(CC(C)(C)C(O)=O)n(Cc2ccc(Cl)cc2)c2ccc(OCc3ccncc3)cc12
Show InChI InChI=1S/C30H33ClN2O3S/c1-29(2,3)37-27-24-16-23(36-19-21-12-14-32-15-13-21)10-11-25(24)33(18-20-6-8-22(31)9-7-20)26(27)17-30(4,5)28(34)35/h6-16H,17-19H2,1-5H3,(H,34,35)
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n/an/a 48n/an/an/an/an/an/a



Merck Frosst Center for Therapeutic Research

Curated by ChEMBL


Assay Description
Measuring the affinity of leukotriene synthesis inhibitor for 5-lipoxygenase activating protein by using [125I]-L-691,831 as radioligand.

Bioorg Med Chem Lett 9: 2391-6 (1999)


BindingDB Entry DOI: 10.7270/Q26T0KTJ
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM50080246
PNG
(3-[3-tert-Butylsulfanyl-1-(4-chloro-benzyl)-5-(qui...)
Show SMILES CC(C)(C)Sc1c(CC(C)(C)C(O)=O)n(Cc2ccc(Cl)cc2)c2ccc(OCc3cnc4ccccc4c3)cc12
Show InChI InChI=1S/C34H35ClN2O3S/c1-33(2,3)41-31-27-17-26(40-21-23-16-24-8-6-7-9-28(24)36-19-23)14-15-29(27)37(20-22-10-12-25(35)13-11-22)30(31)18-34(4,5)32(38)39/h6-17,19H,18,20-21H2,1-5H3,(H,38,39)
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n/an/a 48n/an/an/an/an/an/a



Merck Frosst Center for Therapeutic Research

Curated by ChEMBL


Assay Description
Measuring the affinity of leukotriene synthesis inhibitor for 5-lipoxygenase activating protein by using [125I]-L-691,831 as radioligand.

Bioorg Med Chem Lett 9: 2391-6 (1999)


BindingDB Entry DOI: 10.7270/Q26T0KTJ
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM50080234
PNG
(3-[3-tert-Butylsulfanyl-1-(4-chloro-benzyl)-5-(pyr...)
Show SMILES CC(C)(C)Sc1c(CC(C)(C)C(O)=O)n(Cc2ccc(Cl)cc2)c2ccc(OCc3cccnc3)cc12
Show InChI InChI=1S/C30H33ClN2O3S/c1-29(2,3)37-27-24-15-23(36-19-21-7-6-14-32-17-21)12-13-25(24)33(18-20-8-10-22(31)11-9-20)26(27)16-30(4,5)28(34)35/h6-15,17H,16,18-19H2,1-5H3,(H,34,35)
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n/an/a 59n/an/an/an/an/an/a



Merck Frosst Center for Therapeutic Research

Curated by ChEMBL


Assay Description
Measuring the affinity of leukotriene synthesis inhibitor for 5-lipoxygenase activating protein by using [125I]-L-691,831 as radioligand.

Bioorg Med Chem Lett 9: 2391-6 (1999)


BindingDB Entry DOI: 10.7270/Q26T0KTJ
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM50080239
PNG
(3-[3-tert-Butylsulfanyl-1-(4-chloro-benzyl)-5-(qui...)
Show SMILES CC(C)(C)Sc1c(CC(C)(C)C(O)=O)n(Cc2ccc(Cl)cc2)c2ccc(OCc3ccnc4ccccc34)cc12
Show InChI InChI=1S/C34H35ClN2O3S/c1-33(2,3)41-31-27-18-25(40-21-23-16-17-36-28-9-7-6-8-26(23)28)14-15-29(27)37(20-22-10-12-24(35)13-11-22)30(31)19-34(4,5)32(38)39/h6-18H,19-21H2,1-5H3,(H,38,39)
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n/an/a 62n/an/an/an/an/an/a



Merck Frosst Center for Therapeutic Research

Curated by ChEMBL


Assay Description
Measuring the affinity of leukotriene synthesis inhibitor for 5-lipoxygenase activating protein by using [125I]-L-691,831 as radioligand.

Bioorg Med Chem Lett 9: 2391-6 (1999)


BindingDB Entry DOI: 10.7270/Q26T0KTJ
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM50080235
PNG
(3-[3-tert-Butylsulfanyl-1-(4-chloro-benzyl)-5-(thi...)
Show SMILES CC(C)(C)Sc1c(CC(C)(C)C(O)=O)n(Cc2ccc(Cl)cc2)c2ccc(OCc3cccs3)cc12
Show InChI InChI=1S/C29H32ClNO3S2/c1-28(2,3)36-26-23-15-21(34-18-22-7-6-14-35-22)12-13-24(23)31(17-19-8-10-20(30)11-9-19)25(26)16-29(4,5)27(32)33/h6-15H,16-18H2,1-5H3,(H,32,33)
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n/an/a 70n/an/an/an/an/an/a



Merck Frosst Center for Therapeutic Research

Curated by ChEMBL


Assay Description
Measuring the affinity of leukotriene synthesis inhibitor for 5-lipoxygenase activating protein by using [125I]-L-691,831 as radioligand.

Bioorg Med Chem Lett 9: 2391-6 (1999)


BindingDB Entry DOI: 10.7270/Q26T0KTJ
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM50080260
PNG
(3-[3-tert-Butylsulfanyl-1-(4-chloro-benzyl)-5-(6-m...)
Show SMILES COc1ccc2nc(COc3ccc4n(Cc5ccc(Cl)cc5)c(CC(C)(C)C(O)=O)c(SC(C)(C)C)c4c3)sc2c1
Show InChI InChI=1S/C33H35ClN2O4S2/c1-32(2,3)42-30-24-15-23(40-19-29-35-25-13-11-22(39-6)16-28(25)41-29)12-14-26(24)36(18-20-7-9-21(34)10-8-20)27(30)17-33(4,5)31(37)38/h7-16H,17-19H2,1-6H3,(H,37,38)
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n/an/a 73n/an/an/an/an/an/a



Merck Frosst Center for Therapeutic Research

Curated by ChEMBL


Assay Description
Measuring the affinity of leukotriene synthesis inhibitor for 5-lipoxygenase activating protein by using [125I]-L-691,831 as radioligand.

Bioorg Med Chem Lett 9: 2391-6 (1999)


BindingDB Entry DOI: 10.7270/Q26T0KTJ
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM50080259
PNG
(3-[3-tert-Butylsulfanyl-1-(4-chloro-benzyl)-4-(qui...)
Show SMILES CC(C)(C)Sc1c(CC(C)(C)C(O)=O)n(Cc2ccc(Cl)cc2)c2cccc(OCc3ccc4ccccc4n3)c12
Show InChI InChI=1S/C34H35ClN2O3S/c1-33(2,3)41-31-28(19-34(4,5)32(38)39)37(20-22-13-16-24(35)17-14-22)27-11-8-12-29(30(27)31)40-21-25-18-15-23-9-6-7-10-26(23)36-25/h6-18H,19-21H2,1-5H3,(H,38,39)
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n/an/a 85n/an/an/an/an/an/a



Merck Frosst Center for Therapeutic Research

Curated by ChEMBL


Assay Description
Measuring the affinity of leukotriene synthesis inhibitor for 5-lipoxygenase activating protein by using [125I]-L-691,831 as radioligand.

Bioorg Med Chem Lett 9: 2391-6 (1999)


BindingDB Entry DOI: 10.7270/Q26T0KTJ
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM50080241
PNG
((+)-3-[3-tert-Butylsulfanyl-1-(4-chloro-benzyl)-5-...)
Show SMILES CC(Oc1ccc2n(Cc3ccc(Cl)cc3)c(CC(C)(C)C(O)=O)c(SC(C)(C)C)c2c1)c1ccc2ccccc2n1
Show InChI InChI=1S/C35H37ClN2O3S/c1-22(28-17-13-24-9-7-8-10-29(24)37-28)41-26-16-18-30-27(19-26)32(42-34(2,3)4)31(20-35(5,6)33(39)40)38(30)21-23-11-14-25(36)15-12-23/h7-19,22H,20-21H2,1-6H3,(H,39,40)
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n/an/a 116n/an/an/an/an/an/a



Merck Frosst Center for Therapeutic Research

Curated by ChEMBL


Assay Description
Measuring the affinity of leukotriene synthesis inhibitor for 5-lipoxygenase activating protein by using [125I]-L-691,831 as radioligand.

Bioorg Med Chem Lett 9: 2391-6 (1999)


BindingDB Entry DOI: 10.7270/Q26T0KTJ
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM50080241
PNG
((+)-3-[3-tert-Butylsulfanyl-1-(4-chloro-benzyl)-5-...)
Show SMILES CC(Oc1ccc2n(Cc3ccc(Cl)cc3)c(CC(C)(C)C(O)=O)c(SC(C)(C)C)c2c1)c1ccc2ccccc2n1
Show InChI InChI=1S/C35H37ClN2O3S/c1-22(28-17-13-24-9-7-8-10-29(24)37-28)41-26-16-18-30-27(19-26)32(42-34(2,3)4)31(20-35(5,6)33(39)40)38(30)21-23-11-14-25(36)15-12-23/h7-19,22H,20-21H2,1-6H3,(H,39,40)
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n/an/a 116n/an/an/an/an/an/a



Merck Frosst Center for Therapeutic Research

Curated by ChEMBL


Assay Description
Measuring the affinity of leukotriene synthesis inhibitor for 5-lipoxygenase activating protein by using [125I]-L-691,831 as radioligand.

Bioorg Med Chem Lett 9: 2391-6 (1999)


BindingDB Entry DOI: 10.7270/Q26T0KTJ
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM50080244
PNG
(3-[3-tert-Butylsulfanyl-1-(4-chloro-benzyl)-5-(5-t...)
Show SMILES CC(C)(C)Sc1c(CC(C)(C)C(O)=O)n(Cc2ccc(Cl)cc2)c2ccc(OCc3nc4cc(ccc4s3)C(F)(F)F)cc12
Show InChI InChI=1S/C33H32ClF3N2O3S2/c1-31(2,3)44-29-23-15-22(42-18-28-38-24-14-20(33(35,36)37)8-13-27(24)43-28)11-12-25(23)39(17-19-6-9-21(34)10-7-19)26(29)16-32(4,5)30(40)41/h6-15H,16-18H2,1-5H3,(H,40,41)
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n/an/a 186n/an/an/an/an/an/a



Merck Frosst Center for Therapeutic Research

Curated by ChEMBL


Assay Description
Measuring the affinity of leukotriene synthesis inhibitor for 5-lipoxygenase activating protein by using [125I]-L-691,831 as radioligand.

Bioorg Med Chem Lett 9: 2391-6 (1999)


BindingDB Entry DOI: 10.7270/Q26T0KTJ
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM50080257
PNG
(3-[3-tert-Butylsulfanyl-1-(4-chloro-benzyl)-5-(1-q...)
Show SMILES CCCC(Oc1ccc2n(Cc3ccc(Cl)cc3)c(CC(C)(C)C(O)=O)c(SC(C)(C)C)c2c1)c1ccc2ccccc2n1
Show InChI InChI=1S/C37H41ClN2O3S/c1-7-10-33(30-19-15-25-11-8-9-12-29(25)39-30)43-27-18-20-31-28(21-27)34(44-36(2,3)4)32(22-37(5,6)35(41)42)40(31)23-24-13-16-26(38)17-14-24/h8-9,11-21,33H,7,10,22-23H2,1-6H3,(H,41,42)
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n/an/a 350n/an/an/an/an/an/a



Merck Frosst Center for Therapeutic Research

Curated by ChEMBL


Assay Description
Measuring the affinity of leukotriene synthesis inhibitor for 5-lipoxygenase activating protein by using [125I]-L-691,831 as radioligand.

Bioorg Med Chem Lett 9: 2391-6 (1999)


BindingDB Entry DOI: 10.7270/Q26T0KTJ
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM50080263
PNG
(3-[3-tert-Butylsulfanyl-1-(4-chloro-benzyl)-6-(qui...)
Show SMILES CC(C)(C)Sc1c(CC(C)(C)C(O)=O)n(Cc2ccc(Cl)cc2)c2cc(OCc3ccc4ccccc4n3)ccc12
Show InChI InChI=1S/C34H35ClN2O3S/c1-33(2,3)41-31-27-17-16-26(40-21-25-15-12-23-8-6-7-9-28(23)36-25)18-29(27)37(20-22-10-13-24(35)14-11-22)30(31)19-34(4,5)32(38)39/h6-18H,19-21H2,1-5H3,(H,38,39)
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n/an/a 428n/an/an/an/an/an/a



Merck Frosst Center for Therapeutic Research

Curated by ChEMBL


Assay Description
Measuring the affinity of leukotriene synthesis inhibitor for 5-lipoxygenase activating protein by using [125I]-L-691,831 as radioligand.

Bioorg Med Chem Lett 9: 2391-6 (1999)


BindingDB Entry DOI: 10.7270/Q26T0KTJ
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM50080262
PNG
(3-[3-tert-Butylsulfanyl-1-(4-chloro-benzyl)-7-(qui...)
Show SMILES CC(C)(C)Sc1c(CC(C)(C)C(O)=O)n(Cc2ccc(Cl)cc2)c2c(OCc3ccc4ccccc4n3)cccc12
Show InChI InChI=1S/C34H35ClN2O3S/c1-33(2,3)41-31-26-10-8-12-29(40-21-25-18-15-23-9-6-7-11-27(23)36-25)30(26)37(20-22-13-16-24(35)17-14-22)28(31)19-34(4,5)32(38)39/h6-18H,19-21H2,1-5H3,(H,38,39)
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n/an/a 1.96E+3n/an/an/an/an/an/a



Merck Frosst Center for Therapeutic Research

Curated by ChEMBL


Assay Description
Measuring the affinity of leukotriene synthesis inhibitor for 5-lipoxygenase activating protein by using [125I]-L-691,831 as radioligand.

Bioorg Med Chem Lett 9: 2391-6 (1999)


BindingDB Entry DOI: 10.7270/Q26T0KTJ
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%