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PubMed code 10743944

Compile data set for download or QSAR
Found 68 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Gonadotropin-releasing hormone receptor


(Rattus norvegicus)		BDBM50086620
PNG
(CHEMBL138866 | Trifluoro-acetate2-{2-[7-chloro-3-(...)
Show SMILES Cc1cc(C)cc(c1)-c1c(OCCC2CCCC[NH2+]2)c2cc(C(=O)Nc3ccnc(C)n3)c(Cl)cc2[nH]c1=O
Show InChI InChI=1S/C30H32ClN5O3/c1-17-12-18(2)14-20(13-17)27-28(39-11-8-21-6-4-5-9-33-21)23-15-22(24(31)16-25(23)35-30(27)38)29(37)36-26-7-10-32-19(3)34-26/h7,10,12-16,21,33H,4-6,8-9,11H2,1-3H3,(H,35,38)(H,32,34,36,37)/p+1
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n/an/a 1.80n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against rat CHO cells stably expressing human gonadotropin-releasing hormone receptor

Bioorg Med Chem Lett 10: 443-7 (2000)


BindingDB Entry DOI: 10.7270/Q25Q4V99
More data for this
Ligand-Target Pair
Gonadotropin-releasing hormone receptor


(Homo sapiens (Human))		BDBM50086620
PNG
(CHEMBL138866 | Trifluoro-acetate2-{2-[7-chloro-3-(...)
Show SMILES Cc1cc(C)cc(c1)-c1c(OCCC2CCCC[NH2+]2)c2cc(C(=O)Nc3ccnc(C)n3)c(Cl)cc2[nH]c1=O
Show InChI InChI=1S/C30H32ClN5O3/c1-17-12-18(2)14-20(13-17)27-28(39-11-8-21-6-4-5-9-33-21)23-15-22(24(31)16-25(23)35-30(27)38)29(37)36-26-7-10-32-19(3)34-26/h7,10,12-16,21,33H,4-6,8-9,11H2,1-3H3,(H,35,38)(H,32,34,36,37)/p+1
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against rat CHO cells stably expressing human gonadotropin-releasing hormone receptor

Bioorg Med Chem Lett 10: 443-7 (2000)


BindingDB Entry DOI: 10.7270/Q25Q4V99
More data for this
Ligand-Target Pair
Gonadotropin-releasing hormone receptor


(Homo sapiens (Human))		BDBM50086625
PNG
(CHEMBL341717 | Trifluoro-acetate2-{2-[7-chloro-3-(...)
Show SMILES Cc1cc(NC(=O)c2cc3c(OCCC4CCCC[NH2+]4)c(-c4cc(C)cc(C)c4)c(=O)[nH]c3cc2Cl)sn1
Show InChI InChI=1S/C29H31ClN4O3S/c1-16-10-17(2)12-19(11-16)26-27(37-9-7-20-6-4-5-8-31-20)22-14-21(23(30)15-24(22)32-29(26)36)28(35)33-25-13-18(3)34-38-25/h10-15,20,31H,4-9H2,1-3H3,(H,32,36)(H,33,35)/p+1
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n/an/a 2.90n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibition of GnRH-stimulated phosphatidyl inositol hydrolysis in CHO cells stably expressing gonadotropin-releasing hormone receptor.

Bioorg Med Chem Lett 10: 443-7 (2000)


BindingDB Entry DOI: 10.7270/Q25Q4V99
More data for this
Ligand-Target Pair
Gonadotropin-releasing hormone receptor


(Rattus norvegicus)		BDBM50086607
PNG
(CHEMBL341809 | Trifluoro-acetate2-{2-[7-chloro-3-(...)
Show SMILES Cc1cc(C)cc(c1)-c1c(OCCC2CCCC[NH2+]2)c2cc(C(=O)Nc3ccncn3)c(Cl)cc2[nH]c1=O
Show InChI InChI=1S/C29H30ClN5O3/c1-17-11-18(2)13-19(12-17)26-27(38-10-7-20-5-3-4-8-32-20)22-14-21(23(30)15-24(22)34-29(26)37)28(36)35-25-6-9-31-16-33-25/h6,9,11-16,20,32H,3-5,7-8,10H2,1-2H3,(H,34,37)(H,31,33,35,36)/p+1
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against rat CHO cells stably expressing human gonadotropin-releasing hormone receptor

Bioorg Med Chem Lett 10: 443-7 (2000)


BindingDB Entry DOI: 10.7270/Q25Q4V99
More data for this
Ligand-Target Pair
Gonadotropin-releasing hormone receptor


(Homo sapiens (Human))		BDBM50086613
PNG
(CHEMBL138999 | Trifluoro-acetate2-{2-[7-chloro-3-(...)
Show SMILES Cc1cc(C)cc(c1)-c1c(OCCC2CCCC[NH2+]2)c2cc(C(=O)Nc3ccccn3)c(Cl)cc2[nH]c1=O
Show InChI InChI=1S/C30H31ClN4O3/c1-18-13-19(2)15-20(14-18)27-28(38-12-9-21-7-3-5-10-32-21)23-16-22(24(31)17-25(23)34-30(27)37)29(36)35-26-8-4-6-11-33-26/h4,6,8,11,13-17,21,32H,3,5,7,9-10,12H2,1-2H3,(H,34,37)(H,33,35,36)/p+1
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against rat CHO cells stably expressing human gonadotropin-releasing hormone receptor

Bioorg Med Chem Lett 10: 443-7 (2000)


BindingDB Entry DOI: 10.7270/Q25Q4V99
More data for this
Ligand-Target Pair
Gonadotropin-releasing hormone receptor


(Homo sapiens (Human))		BDBM50086608
PNG
(CHEMBL343396 | Trifluoro-acetate2-{2-[7-chloro-3-(...)
Show SMILES Cc1cc(C)cc(c1)-c1c(OCCC2CCCC[NH2+]2)c2cc(C(=O)Nc3ccncc3)c(Cl)cc2[nH]c1=O
Show InChI InChI=1S/C30H31ClN4O3/c1-18-13-19(2)15-20(14-18)27-28(38-12-8-21-5-3-4-9-33-21)24-16-23(25(31)17-26(24)35-30(27)37)29(36)34-22-6-10-32-11-7-22/h6-7,10-11,13-17,21,33H,3-5,8-9,12H2,1-2H3,(H,35,37)(H,32,34,36)/p+1
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibition of GnRH-stimulated phosphatidyl inositol hydrolysis in CHO cells stably expressing gonadotropin-releasing hormone receptor.

Bioorg Med Chem Lett 10: 443-7 (2000)


BindingDB Entry DOI: 10.7270/Q25Q4V99
More data for this
Ligand-Target Pair
Gonadotropin-releasing hormone receptor


(Homo sapiens (Human))		BDBM50403824
PNG
(CHEMBL2111956)
Show SMILES Cc1cc(C)cc(c1)-c1c(OCC[C@@H]2CCCCN2)c2cc(C(=O)Nc3ccncn3)c(Cl)cc2[nH]c1=O |r|
Show InChI InChI=1S/C29H30ClN5O3/c1-17-11-18(2)13-19(12-17)26-27(38-10-7-20-5-3-4-8-32-20)22-14-21(23(30)15-24(22)34-29(26)37)28(36)35-25-6-9-31-16-33-25/h6,9,11-16,20,32H,3-5,7-8,10H2,1-2H3,(H,34,37)(H,31,33,35,36)/t20-/m0/s1
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibition of GnRH-stimulated phosphatidyl inositol hydrolysis in CHO cells stably expressing gonadotropin-releasing hormone receptor.

Bioorg Med Chem Lett 10: 443-7 (2000)


BindingDB Entry DOI: 10.7270/Q25Q4V99
More data for this
Ligand-Target Pair
Gonadotropin-releasing hormone receptor


(Homo sapiens (Human))		BDBM50403824
PNG
(CHEMBL2111956)
Show SMILES Cc1cc(C)cc(c1)-c1c(OCC[C@@H]2CCCCN2)c2cc(C(=O)Nc3ccncn3)c(Cl)cc2[nH]c1=O |r|
Show InChI InChI=1S/C29H30ClN5O3/c1-17-11-18(2)13-19(12-17)26-27(38-10-7-20-5-3-4-8-32-20)22-14-21(23(30)15-24(22)34-29(26)37)28(36)35-25-6-9-31-16-33-25/h6,9,11-16,20,32H,3-5,7-8,10H2,1-2H3,(H,34,37)(H,31,33,35,36)/t20-/m0/s1
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against rat CHO cells stably expressing human gonadotropin-releasing hormone receptor

Bioorg Med Chem Lett 10: 443-7 (2000)


BindingDB Entry DOI: 10.7270/Q25Q4V99
More data for this
Ligand-Target Pair
Gonadotropin-releasing hormone receptor


(Homo sapiens (Human))		BDBM50403825
PNG
(CHEMBL2111955)
Show SMILES Cc1cc(C)cc(c1)-c1c(OCC[C@@H]2CCCCN2)c2cc(C(=O)Nc3cnsn3)c(Cl)cc2[nH]c1=O |r|
Show InChI InChI=1S/C27H28ClN5O3S/c1-15-9-16(2)11-17(10-15)24-25(36-8-6-18-5-3-4-7-29-18)20-12-19(21(28)13-22(20)31-27(24)35)26(34)32-23-14-30-37-33-23/h9-14,18,29H,3-8H2,1-2H3,(H,31,35)(H,32,33,34)/t18-/m0/s1
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibition of GnRH-stimulated phosphatidyl inositol hydrolysis in CHO cells stably expressing gonadotropin-releasing hormone receptor.

Bioorg Med Chem Lett 10: 443-7 (2000)


BindingDB Entry DOI: 10.7270/Q25Q4V99
More data for this
Ligand-Target Pair
Gonadotropin-releasing hormone receptor


(Homo sapiens (Human))		BDBM50403825
PNG
(CHEMBL2111955)
Show SMILES Cc1cc(C)cc(c1)-c1c(OCC[C@@H]2CCCCN2)c2cc(C(=O)Nc3cnsn3)c(Cl)cc2[nH]c1=O |r|
Show InChI InChI=1S/C27H28ClN5O3S/c1-15-9-16(2)11-17(10-15)24-25(36-8-6-18-5-3-4-7-29-18)20-12-19(21(28)13-22(20)31-27(24)35)26(34)32-23-14-30-37-33-23/h9-14,18,29H,3-8H2,1-2H3,(H,31,35)(H,32,33,34)/t18-/m0/s1
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against rat CHO cells stably expressing human gonadotropin-releasing hormone receptor

Bioorg Med Chem Lett 10: 443-7 (2000)


BindingDB Entry DOI: 10.7270/Q25Q4V99
More data for this
Ligand-Target Pair
Gonadotropin-releasing hormone receptor


(Homo sapiens (Human))		BDBM50086609
PNG
(CHEMBL342822 | Trifluoro-acetate2-{2-[7-chloro-3-(...)
Show SMILES Cc1cc(C)cc(c1)-c1c(OCCC2CCCC[NH2+]2)c2cc(C(=O)Nc3cnsn3)c(Cl)cc2[nH]c1=O
Show InChI InChI=1S/C27H28ClN5O3S/c1-15-9-16(2)11-17(10-15)24-25(36-8-6-18-5-3-4-7-29-18)20-12-19(21(28)13-22(20)31-27(24)35)26(34)32-23-14-30-37-33-23/h9-14,18,29H,3-8H2,1-2H3,(H,31,35)(H,32,33,34)/p+1
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibition of GnRH-stimulated phosphatidyl inositol hydrolysis in CHO cells stably expressing gonadotropin-releasing hormone receptor.

Bioorg Med Chem Lett 10: 443-7 (2000)


BindingDB Entry DOI: 10.7270/Q25Q4V99
More data for this
Ligand-Target Pair
Gonadotropin-releasing hormone receptor


(Homo sapiens (Human))		BDBM50086609
PNG
(CHEMBL342822 | Trifluoro-acetate2-{2-[7-chloro-3-(...)
Show SMILES Cc1cc(C)cc(c1)-c1c(OCCC2CCCC[NH2+]2)c2cc(C(=O)Nc3cnsn3)c(Cl)cc2[nH]c1=O
Show InChI InChI=1S/C27H28ClN5O3S/c1-15-9-16(2)11-17(10-15)24-25(36-8-6-18-5-3-4-7-29-18)20-12-19(21(28)13-22(20)31-27(24)35)26(34)32-23-14-30-37-33-23/h9-14,18,29H,3-8H2,1-2H3,(H,31,35)(H,32,33,34)/p+1
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibition of GnRH-stimulated phosphatidyl inositol hydrolysis in CHO cells stably expressing gonadotropin-releasing hormone receptor.

Bioorg Med Chem Lett 10: 443-7 (2000)


BindingDB Entry DOI: 10.7270/Q25Q4V99
More data for this
Ligand-Target Pair
Gonadotropin-releasing hormone receptor


(Rattus norvegicus)		BDBM50086617
PNG
(CHEMBL138464 | Trifluoro-acetate2-{2-[7-chloro-3-(...)
Show SMILES Cc1cc(C)cc(c1)-c1c(OCCC2CCCC[NH2+]2)c2cc(C(=O)Nc3cnccn3)c(Cl)cc2[nH]c1=O
Show InChI InChI=1S/C29H30ClN5O3/c1-17-11-18(2)13-19(12-17)26-27(38-10-6-20-5-3-4-7-32-20)22-14-21(23(30)15-24(22)34-29(26)37)28(36)35-25-16-31-8-9-33-25/h8-9,11-16,20,32H,3-7,10H2,1-2H3,(H,34,37)(H,33,35,36)/p+1
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against rat CHO cells stably expressing human gonadotropin-releasing hormone receptor

Bioorg Med Chem Lett 10: 443-7 (2000)


BindingDB Entry DOI: 10.7270/Q25Q4V99
More data for this
Ligand-Target Pair
Gonadotropin-releasing hormone receptor


(Homo sapiens (Human))		BDBM50086617
PNG
(CHEMBL138464 | Trifluoro-acetate2-{2-[7-chloro-3-(...)
Show SMILES Cc1cc(C)cc(c1)-c1c(OCCC2CCCC[NH2+]2)c2cc(C(=O)Nc3cnccn3)c(Cl)cc2[nH]c1=O
Show InChI InChI=1S/C29H30ClN5O3/c1-17-11-18(2)13-19(12-17)26-27(38-10-6-20-5-3-4-7-32-20)22-14-21(23(30)15-24(22)34-29(26)37)28(36)35-25-16-31-8-9-33-25/h8-9,11-16,20,32H,3-7,10H2,1-2H3,(H,34,37)(H,33,35,36)/p+1
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against rat CHO cells stably expressing human gonadotropin-releasing hormone receptor

Bioorg Med Chem Lett 10: 443-7 (2000)


BindingDB Entry DOI: 10.7270/Q25Q4V99
More data for this
Ligand-Target Pair
Gonadotropin-releasing hormone receptor


(Homo sapiens (Human))		BDBM50086607
PNG
(CHEMBL341809 | Trifluoro-acetate2-{2-[7-chloro-3-(...)
Show SMILES Cc1cc(C)cc(c1)-c1c(OCCC2CCCC[NH2+]2)c2cc(C(=O)Nc3ccncn3)c(Cl)cc2[nH]c1=O
Show InChI InChI=1S/C29H30ClN5O3/c1-17-11-18(2)13-19(12-17)26-27(38-10-7-20-5-3-4-8-32-20)22-14-21(23(30)15-24(22)34-29(26)37)28(36)35-25-6-9-31-16-33-25/h6,9,11-16,20,32H,3-5,7-8,10H2,1-2H3,(H,34,37)(H,31,33,35,36)/p+1
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibition of GnRH-stimulated phosphatidyl inositol hydrolysis in CHO cells stably expressing gonadotropin-releasing hormone receptor.

Bioorg Med Chem Lett 10: 443-7 (2000)


BindingDB Entry DOI: 10.7270/Q25Q4V99
More data for this
Ligand-Target Pair
Gonadotropin-releasing hormone receptor


(Homo sapiens (Human))		BDBM50086607
PNG
(CHEMBL341809 | Trifluoro-acetate2-{2-[7-chloro-3-(...)
Show SMILES Cc1cc(C)cc(c1)-c1c(OCCC2CCCC[NH2+]2)c2cc(C(=O)Nc3ccncn3)c(Cl)cc2[nH]c1=O
Show InChI InChI=1S/C29H30ClN5O3/c1-17-11-18(2)13-19(12-17)26-27(38-10-7-20-5-3-4-8-32-20)22-14-21(23(30)15-24(22)34-29(26)37)28(36)35-25-6-9-31-16-33-25/h6,9,11-16,20,32H,3-5,7-8,10H2,1-2H3,(H,34,37)(H,31,33,35,36)/p+1
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibition of GnRH-stimulated phosphatidyl inositol hydrolysis in CHO cells stably expressing gonadotropin-releasing hormone receptor.

Bioorg Med Chem Lett 10: 443-7 (2000)


BindingDB Entry DOI: 10.7270/Q25Q4V99
More data for this
Ligand-Target Pair
Gonadotropin-releasing hormone receptor


(Homo sapiens (Human))		BDBM50086618
PNG
(CHEMBL139292 | Trifluoro-acetate2-{2-[7-chloro-3-(...)
Show SMILES COc1nccc(NC(=O)c2cc3c(OCCC4CCCC[NH2+]4)c(-c4cc(C)cc(C)c4)c(=O)[nH]c3cc2Cl)n1
Show InChI InChI=1S/C30H32ClN5O4/c1-17-12-18(2)14-19(13-17)26-27(40-11-8-20-6-4-5-9-32-20)22-15-21(23(31)16-24(22)34-29(26)38)28(37)35-25-7-10-33-30(36-25)39-3/h7,10,12-16,20,32H,4-6,8-9,11H2,1-3H3,(H,34,38)(H,33,35,36,37)/p+1
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against rat CHO cells stably expressing human gonadotropin-releasing hormone receptor

Bioorg Med Chem Lett 10: 443-7 (2000)


BindingDB Entry DOI: 10.7270/Q25Q4V99
More data for this
Ligand-Target Pair
Gonadotropin-releasing hormone receptor


(Homo sapiens (Human))		BDBM50086608
PNG
(CHEMBL343396 | Trifluoro-acetate2-{2-[7-chloro-3-(...)
Show SMILES Cc1cc(C)cc(c1)-c1c(OCCC2CCCC[NH2+]2)c2cc(C(=O)Nc3ccncc3)c(Cl)cc2[nH]c1=O
Show InChI InChI=1S/C30H31ClN4O3/c1-18-13-19(2)15-20(14-18)27-28(38-12-8-21-5-3-4-9-33-21)24-16-23(25(31)17-26(24)35-30(27)37)29(36)34-22-6-10-32-11-7-22/h6-7,10-11,13-17,21,33H,3-5,8-9,12H2,1-2H3,(H,35,37)(H,32,34,36)/p+1
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n/an/a 11n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibition of GnRH-stimulated phosphatidyl inositol hydrolysis in CHO cells stably expressing gonadotropin-releasing hormone receptor.

Bioorg Med Chem Lett 10: 443-7 (2000)


BindingDB Entry DOI: 10.7270/Q25Q4V99
More data for this
Ligand-Target Pair
Gonadotropin-releasing hormone receptor


(Homo sapiens (Human))		BDBM50086614
PNG
(CHEMBL138747 | Trifluoro-acetate2-{2-[7-chloro-6-(...)
Show SMILES Cc1cc(C)cc(c1)-c1c(OCCC2CCCC[NH2+]2)c2cc(C(=O)Nc3cc(Cl)ncn3)c(Cl)cc2[nH]c1=O
Show InChI InChI=1S/C29H29Cl2N5O3/c1-16-9-17(2)11-18(10-16)26-27(39-8-6-19-5-3-4-7-32-19)21-12-20(22(30)13-23(21)35-29(26)38)28(37)36-25-14-24(31)33-15-34-25/h9-15,19,32H,3-8H2,1-2H3,(H,35,38)(H,33,34,36,37)/p+1
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n/an/a 14.5n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibition of GnRH-stimulated phosphatidyl inositol hydrolysis in CHO cells stably expressing gonadotropin-releasing hormone receptor.

Bioorg Med Chem Lett 10: 443-7 (2000)


BindingDB Entry DOI: 10.7270/Q25Q4V99
More data for this
Ligand-Target Pair
Gonadotropin-releasing hormone receptor


(Homo sapiens (Human))		BDBM50086614
PNG
(CHEMBL138747 | Trifluoro-acetate2-{2-[7-chloro-6-(...)
Show SMILES Cc1cc(C)cc(c1)-c1c(OCCC2CCCC[NH2+]2)c2cc(C(=O)Nc3cc(Cl)ncn3)c(Cl)cc2[nH]c1=O
Show InChI InChI=1S/C29H29Cl2N5O3/c1-16-9-17(2)11-18(10-16)26-27(39-8-6-19-5-3-4-7-32-19)21-12-20(22(30)13-23(21)35-29(26)38)28(37)36-25-14-24(31)33-15-34-25/h9-15,19,32H,3-8H2,1-2H3,(H,35,38)(H,33,34,36,37)/p+1
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n/an/a 15n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibition of GnRH-stimulated phosphatidyl inositol hydrolysis in CHO cells stably expressing gonadotropin-releasing hormone receptor.

Bioorg Med Chem Lett 10: 443-7 (2000)


BindingDB Entry DOI: 10.7270/Q25Q4V99
More data for this
Ligand-Target Pair
Gonadotropin-releasing hormone receptor


(Homo sapiens (Human))		BDBM50086615
PNG
(CHEMBL139291 | Trifluoro-acetate2-{2-[7-chloro-6-(...)
Show SMILES Cc1cc(C)cc(c1)-c1c(OCCC2CCCC[NH2+]2)c2cc(C(=O)Nc3ccnc(n3)C3CC3)c(Cl)cc2[nH]c1=O
Show InChI InChI=1S/C32H34ClN5O3/c1-18-13-19(2)15-21(14-18)28-29(41-12-9-22-5-3-4-10-34-22)24-16-23(25(33)17-26(24)36-32(28)40)31(39)38-27-8-11-35-30(37-27)20-6-7-20/h8,11,13-17,20,22,34H,3-7,9-10,12H2,1-2H3,(H,36,40)(H,35,37,38,39)/p+1
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n/an/a 15n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibition of GnRH-stimulated phosphatidyl inositol hydrolysis in CHO cells stably expressing gonadotropin-releasing hormone receptor.

Bioorg Med Chem Lett 10: 443-7 (2000)


BindingDB Entry DOI: 10.7270/Q25Q4V99
More data for this
Ligand-Target Pair
Gonadotropin-releasing hormone receptor


(Homo sapiens (Human))		BDBM50086617
PNG
(CHEMBL138464 | Trifluoro-acetate2-{2-[7-chloro-3-(...)
Show SMILES Cc1cc(C)cc(c1)-c1c(OCCC2CCCC[NH2+]2)c2cc(C(=O)Nc3cnccn3)c(Cl)cc2[nH]c1=O
Show InChI InChI=1S/C29H30ClN5O3/c1-17-11-18(2)13-19(12-17)26-27(38-10-6-20-5-3-4-7-32-20)22-14-21(23(30)15-24(22)34-29(26)37)28(36)35-25-16-31-8-9-33-25/h8-9,11-16,20,32H,3-7,10H2,1-2H3,(H,34,37)(H,33,35,36)/p+1
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n/an/a 16n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibition of GnRH-stimulated phosphatidyl inositol hydrolysis in CHO cells stably expressing gonadotropin-releasing hormone receptor.

Bioorg Med Chem Lett 10: 443-7 (2000)


BindingDB Entry DOI: 10.7270/Q25Q4V99
More data for this
Ligand-Target Pair
Gonadotropin-releasing hormone receptor


(Homo sapiens (Human))		BDBM50086613
PNG
(CHEMBL138999 | Trifluoro-acetate2-{2-[7-chloro-3-(...)
Show SMILES Cc1cc(C)cc(c1)-c1c(OCCC2CCCC[NH2+]2)c2cc(C(=O)Nc3ccccn3)c(Cl)cc2[nH]c1=O
Show InChI InChI=1S/C30H31ClN4O3/c1-18-13-19(2)15-20(14-18)27-28(38-12-9-21-7-3-5-10-32-21)23-16-22(24(31)17-25(23)34-30(27)37)29(36)35-26-8-4-6-11-33-26/h4,6,8,11,13-17,21,32H,3,5,7,9-10,12H2,1-2H3,(H,34,37)(H,33,35,36)/p+1
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n/an/a 19n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibition of GnRH-stimulated phosphatidyl inositol hydrolysis in CHO cells stably expressing gonadotropin-releasing hormone receptor.

Bioorg Med Chem Lett 10: 443-7 (2000)


BindingDB Entry DOI: 10.7270/Q25Q4V99
More data for this
Ligand-Target Pair
Gonadotropin-releasing hormone receptor


(Homo sapiens (Human))		BDBM50086625
PNG
(CHEMBL341717 | Trifluoro-acetate2-{2-[7-chloro-3-(...)
Show SMILES Cc1cc(NC(=O)c2cc3c(OCCC4CCCC[NH2+]4)c(-c4cc(C)cc(C)c4)c(=O)[nH]c3cc2Cl)sn1
Show InChI InChI=1S/C29H31ClN4O3S/c1-16-10-17(2)12-19(11-16)26-27(37-9-7-20-6-4-5-8-31-20)22-14-21(23(30)15-24(22)32-29(26)36)28(35)33-25-13-18(3)34-38-25/h10-15,20,31H,4-9H2,1-3H3,(H,32,36)(H,33,35)/p+1
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n/an/a 22n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibition of GnRH-stimulated phosphatidyl inositol hydrolysis in CHO cells stably expressing gonadotropin-releasing hormone receptor.

Bioorg Med Chem Lett 10: 443-7 (2000)


BindingDB Entry DOI: 10.7270/Q25Q4V99
More data for this
Ligand-Target Pair
Gonadotropin-releasing hormone receptor


(Homo sapiens (Human))		BDBM50086624
PNG
(CHEMBL141221 | Trifluoro-acetate2-{2-[7-chloro-3-(...)
Show SMILES Cc1cc(C)cc(c1)-c1c(OCCC2CCCC[NH2+]2)c2cc(C(=O)Nc3nncs3)c(Cl)cc2[nH]c1=O
Show InChI InChI=1S/C27H28ClN5O3S/c1-15-9-16(2)11-17(10-15)23-24(36-8-6-18-5-3-4-7-29-18)20-12-19(21(28)13-22(20)31-26(23)35)25(34)32-27-33-30-14-37-27/h9-14,18,29H,3-8H2,1-2H3,(H,31,35)(H,32,33,34)/p+1
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n/an/a 22n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibition of GnRH-stimulated phosphatidyl inositol hydrolysis in CHO cells stably expressing gonadotropin-releasing hormone receptor.

Bioorg Med Chem Lett 10: 443-7 (2000)


BindingDB Entry DOI: 10.7270/Q25Q4V99
More data for this
Ligand-Target Pair
Gonadotropin-releasing hormone receptor


(Homo sapiens (Human))		BDBM50086628
PNG
(CHEMBL344688 | Trifluoro-acetate2-{2-[7-chloro-3-(...)
Show SMILES Cc1cc(NC(=O)c2cc3c(OCCC4CCCC[NH2+]4)c(-c4cc(C)cc(C)c4)c(=O)[nH]c3cc2Cl)on1
Show InChI InChI=1S/C29H31ClN4O4/c1-16-10-17(2)12-19(11-16)26-27(37-9-7-20-6-4-5-8-31-20)22-14-21(23(30)15-24(22)32-29(26)36)28(35)33-25-13-18(3)34-38-25/h10-15,20,31H,4-9H2,1-3H3,(H,32,36)(H,33,35)/p+1
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n/an/a 23n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against rat CHO cells stably expressing human gonadotropin-releasing hormone receptor

Bioorg Med Chem Lett 10: 443-7 (2000)


BindingDB Entry DOI: 10.7270/Q25Q4V99
More data for this
Ligand-Target Pair
Gonadotropin-releasing hormone receptor


(Rattus norvegicus)		BDBM50403825
PNG
(CHEMBL2111955)
Show SMILES Cc1cc(C)cc(c1)-c1c(OCC[C@@H]2CCCCN2)c2cc(C(=O)Nc3cnsn3)c(Cl)cc2[nH]c1=O |r|
Show InChI InChI=1S/C27H28ClN5O3S/c1-15-9-16(2)11-17(10-15)24-25(36-8-6-18-5-3-4-7-29-18)20-12-19(21(28)13-22(20)31-27(24)35)26(34)32-23-14-30-37-33-23/h9-14,18,29H,3-8H2,1-2H3,(H,31,35)(H,32,33,34)/t18-/m0/s1
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n/an/a 24n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibition of GnRH stimulated release of luteinizing hormone from the rat primary pituitary cells.

Bioorg Med Chem Lett 10: 443-7 (2000)


BindingDB Entry DOI: 10.7270/Q25Q4V99
More data for this
Ligand-Target Pair
Gonadotropin-releasing hormone receptor


(Homo sapiens (Human))		BDBM50086626
PNG
(CHEMBL334904 | Trifluoro-acetate2-{2-[7-chloro-3-(...)
Show SMILES Cc1nnc(NC(=O)c2cc3c(OCCC4CCCC[NH2+]4)c(-c4cc(C)cc(C)c4)c(=O)[nH]c3cc2Cl)s1
Show InChI InChI=1S/C28H30ClN5O3S/c1-15-10-16(2)12-18(11-15)24-25(37-9-7-19-6-4-5-8-30-19)21-13-20(22(29)14-23(21)31-27(24)36)26(35)32-28-34-33-17(3)38-28/h10-14,19,30H,4-9H2,1-3H3,(H,31,36)(H,32,34,35)/p+1
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n/an/a 28n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against rat CHO cells stably expressing human gonadotropin-releasing hormone receptor

Bioorg Med Chem Lett 10: 443-7 (2000)


BindingDB Entry DOI: 10.7270/Q25Q4V99
More data for this
Ligand-Target Pair
Gonadotropin-releasing hormone receptor


(Homo sapiens (Human))		BDBM50086623
PNG
(CHEMBL336039 | Trifluoro-acetate2-{2-[7-chloro-3-(...)
Show SMILES Cc1cc(C)cc(c1)-c1c(OCCC2CCCC[NH2+]2)c2cc(C(=O)Nc3cccnc3)c(Cl)cc2[nH]c1=O
Show InChI InChI=1S/C30H31ClN4O3/c1-18-12-19(2)14-20(13-18)27-28(38-11-8-21-6-3-4-10-33-21)24-15-23(25(31)16-26(24)35-30(27)37)29(36)34-22-7-5-9-32-17-22/h5,7,9,12-17,21,33H,3-4,6,8,10-11H2,1-2H3,(H,34,36)(H,35,37)/p+1
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n/an/a 32n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against rat CHO cells stably expressing human gonadotropin-releasing hormone receptor

Bioorg Med Chem Lett 10: 443-7 (2000)


BindingDB Entry DOI: 10.7270/Q25Q4V99
More data for this
Ligand-Target Pair
Gonadotropin-releasing hormone receptor


(Homo sapiens (Human))		BDBM50086624
PNG
(CHEMBL141221 | Trifluoro-acetate2-{2-[7-chloro-3-(...)
Show SMILES Cc1cc(C)cc(c1)-c1c(OCCC2CCCC[NH2+]2)c2cc(C(=O)Nc3nncs3)c(Cl)cc2[nH]c1=O
Show InChI InChI=1S/C27H28ClN5O3S/c1-15-9-16(2)11-17(10-15)23-24(36-8-6-18-5-3-4-7-29-18)20-12-19(21(28)13-22(20)31-26(23)35)25(34)32-27-33-30-14-37-27/h9-14,18,29H,3-8H2,1-2H3,(H,31,35)(H,32,33,34)/p+1
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n/an/a 32n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against rat CHO cells stably expressing human gonadotropin-releasing hormone receptor

Bioorg Med Chem Lett 10: 443-7 (2000)


BindingDB Entry DOI: 10.7270/Q25Q4V99
More data for this
Ligand-Target Pair
Gonadotropin-releasing hormone receptor


(Homo sapiens (Human))		BDBM50086620
PNG
(CHEMBL138866 | Trifluoro-acetate2-{2-[7-chloro-3-(...)
Show SMILES Cc1cc(C)cc(c1)-c1c(OCCC2CCCC[NH2+]2)c2cc(C(=O)Nc3ccnc(C)n3)c(Cl)cc2[nH]c1=O
Show InChI InChI=1S/C30H32ClN5O3/c1-17-12-18(2)14-20(13-17)27-28(39-11-8-21-6-4-5-9-33-21)23-15-22(24(31)16-25(23)35-30(27)38)29(37)36-26-7-10-32-19(3)34-26/h7,10,12-16,21,33H,4-6,8-9,11H2,1-3H3,(H,35,38)(H,32,34,36,37)/p+1
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n/an/a 33n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibition of GnRH-stimulated phosphatidyl inositol hydrolysis in CHO cells stably expressing gonadotropin-releasing hormone receptor.

Bioorg Med Chem Lett 10: 443-7 (2000)


BindingDB Entry DOI: 10.7270/Q25Q4V99
More data for this
Ligand-Target Pair
Gonadotropin-releasing hormone receptor


(Homo sapiens (Human))		BDBM50086627
PNG
(CHEMBL336884 | Trifluoro-acetate2-{2-[7-chloro-3-(...)
Show SMILES Cc1cc(C)cc(c1)-c1c(OCCC2CCCC[NH2+]2)c2cc(C(=O)Nc3cc(C)ncn3)c(Cl)cc2[nH]c1=O
Show InChI InChI=1S/C30H32ClN5O3/c1-17-10-18(2)12-20(11-17)27-28(39-9-7-21-6-4-5-8-32-21)23-14-22(24(31)15-25(23)35-30(27)38)29(37)36-26-13-19(3)33-16-34-26/h10-16,21,32H,4-9H2,1-3H3,(H,35,38)(H,33,34,36,37)/p+1
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n/an/a 44n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibition of GnRH-stimulated phosphatidyl inositol hydrolysis in CHO cells stably expressing gonadotropin-releasing hormone receptor.

Bioorg Med Chem Lett 10: 443-7 (2000)


BindingDB Entry DOI: 10.7270/Q25Q4V99
More data for this
Ligand-Target Pair
Gonadotropin-releasing hormone receptor


(Homo sapiens (Human))		BDBM50086627
PNG
(CHEMBL336884 | Trifluoro-acetate2-{2-[7-chloro-3-(...)
Show SMILES Cc1cc(C)cc(c1)-c1c(OCCC2CCCC[NH2+]2)c2cc(C(=O)Nc3cc(C)ncn3)c(Cl)cc2[nH]c1=O
Show InChI InChI=1S/C30H32ClN5O3/c1-17-10-18(2)12-20(11-17)27-28(39-9-7-21-6-4-5-8-32-21)23-14-22(24(31)15-25(23)35-30(27)38)29(37)36-26-13-19(3)33-16-34-26/h10-16,21,32H,4-9H2,1-3H3,(H,35,38)(H,33,34,36,37)/p+1
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n/an/a 44n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibition of GnRH-stimulated phosphatidyl inositol hydrolysis in CHO cells stably expressing gonadotropin-releasing hormone receptor.

Bioorg Med Chem Lett 10: 443-7 (2000)


BindingDB Entry DOI: 10.7270/Q25Q4V99
More data for this
Ligand-Target Pair
Gonadotropin-releasing hormone receptor


(Homo sapiens (Human))		BDBM50086619
PNG
(CHEMBL138977 | Trifluoro-acetate2-{2-[7-chloro-6-(...)
Show SMILES CCC(C)N(C(C)CC)C(=O)c1cc2c(OCCC3CCCC[NH2+]3)c(-c3cc(C)cc(C)c3)c(=O)[nH]c2cc1Cl
Show InChI InChI=1S/C33H44ClN3O3/c1-7-22(5)37(23(6)8-2)33(39)26-18-27-29(19-28(26)34)36-32(38)30(24-16-20(3)15-21(4)17-24)31(27)40-14-12-25-11-9-10-13-35-25/h15-19,22-23,25,35H,7-14H2,1-6H3,(H,36,38)/p+1
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n/an/a 45n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against rat CHO cells stably expressing human gonadotropin-releasing hormone receptor

Bioorg Med Chem Lett 10: 443-7 (2000)


BindingDB Entry DOI: 10.7270/Q25Q4V99
More data for this
Ligand-Target Pair
Gonadotropin-releasing hormone receptor


(Homo sapiens (Human))		BDBM50086610
PNG
(CHEMBL139993 | Trifluoro-acetate2-{2-[7-chloro-3-(...)
Show SMILES Cc1cc(NC(=O)c2cc3c(OCCC4CCCC[NH2+]4)c(-c4cc(C)cc(C)c4)c(=O)[nH]c3cc2Cl)no1
Show InChI InChI=1S/C29H31ClN4O4/c1-16-10-17(2)12-19(11-16)26-27(37-9-7-20-6-4-5-8-31-20)22-14-21(23(30)15-24(22)32-29(26)36)28(35)33-25-13-18(3)38-34-25/h10-15,20,31H,4-9H2,1-3H3,(H,32,36)(H,33,34,35)/p+1
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n/an/a 77.5n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibition of GnRH-stimulated phosphatidyl inositol hydrolysis in CHO cells stably expressing gonadotropin-releasing hormone receptor.

Bioorg Med Chem Lett 10: 443-7 (2000)


BindingDB Entry DOI: 10.7270/Q25Q4V99
More data for this
Ligand-Target Pair
Gonadotropin-releasing hormone receptor


(Homo sapiens (Human))		BDBM50086610
PNG
(CHEMBL139993 | Trifluoro-acetate2-{2-[7-chloro-3-(...)
Show SMILES Cc1cc(NC(=O)c2cc3c(OCCC4CCCC[NH2+]4)c(-c4cc(C)cc(C)c4)c(=O)[nH]c3cc2Cl)no1
Show InChI InChI=1S/C29H31ClN4O4/c1-16-10-17(2)12-19(11-16)26-27(37-9-7-20-6-4-5-8-31-20)22-14-21(23(30)15-24(22)32-29(26)36)28(35)33-25-13-18(3)38-34-25/h10-15,20,31H,4-9H2,1-3H3,(H,32,36)(H,33,34,35)/p+1
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibition of GnRH-stimulated phosphatidyl inositol hydrolysis in CHO cells stably expressing gonadotropin-releasing hormone receptor.

Bioorg Med Chem Lett 10: 443-7 (2000)


BindingDB Entry DOI: 10.7270/Q25Q4V99
More data for this
Ligand-Target Pair
Gonadotropin-releasing hormone receptor


(Rattus norvegicus)		BDBM50086614
PNG
(CHEMBL138747 | Trifluoro-acetate2-{2-[7-chloro-6-(...)
Show SMILES Cc1cc(C)cc(c1)-c1c(OCCC2CCCC[NH2+]2)c2cc(C(=O)Nc3cc(Cl)ncn3)c(Cl)cc2[nH]c1=O
Show InChI InChI=1S/C29H29Cl2N5O3/c1-16-9-17(2)11-18(10-16)26-27(39-8-6-19-5-3-4-7-32-19)21-12-20(22(30)13-23(21)35-29(26)38)28(37)36-25-14-24(31)33-15-34-25/h9-15,19,32H,3-8H2,1-2H3,(H,35,38)(H,33,34,36,37)/p+1
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibition of GnRH stimulated release of luteinizing hormone from the rat primary pituitary cells.

Bioorg Med Chem Lett 10: 443-7 (2000)


BindingDB Entry DOI: 10.7270/Q25Q4V99
More data for this
Ligand-Target Pair
Gonadotropin-releasing hormone receptor


(Rattus norvegicus)		BDBM50403824
PNG
(CHEMBL2111956)
Show SMILES Cc1cc(C)cc(c1)-c1c(OCC[C@@H]2CCCCN2)c2cc(C(=O)Nc3ccncn3)c(Cl)cc2[nH]c1=O |r|
Show InChI InChI=1S/C29H30ClN5O3/c1-17-11-18(2)13-19(12-17)26-27(38-10-7-20-5-3-4-8-32-20)22-14-21(23(30)15-24(22)34-29(26)37)28(36)35-25-6-9-31-16-33-25/h6,9,11-16,20,32H,3-5,7-8,10H2,1-2H3,(H,34,37)(H,31,33,35,36)/t20-/m0/s1
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibition of GnRH stimulated release of luteinizing hormone from the rat primary pituitary cells.

Bioorg Med Chem Lett 10: 443-7 (2000)


BindingDB Entry DOI: 10.7270/Q25Q4V99
More data for this
Ligand-Target Pair
Gonadotropin-releasing hormone receptor


(Homo sapiens (Human))		BDBM50086629
PNG
(CHEMBL141750 | Trifluoro-acetate2-{2-[6-[(benzo[1,...)
Show SMILES Cc1cc(C)cc(c1)-c1c(OCCC2CCCC[NH2+]2)c2cc(C(=O)NCc3ccc4OCOc4c3)c(Cl)cc2[nH]c1=O
Show InChI InChI=1S/C33H34ClN3O5/c1-19-11-20(2)13-22(12-19)30-31(40-10-8-23-5-3-4-9-35-23)25-15-24(26(34)16-27(25)37-33(30)39)32(38)36-17-21-6-7-28-29(14-21)42-18-41-28/h6-7,11-16,23,35H,3-5,8-10,17-18H2,1-2H3,(H,36,38)(H,37,39)/p+1
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against rat CHO cells stably expressing human gonadotropin-releasing hormone receptor

Bioorg Med Chem Lett 10: 443-7 (2000)


BindingDB Entry DOI: 10.7270/Q25Q4V99
More data for this
Ligand-Target Pair
Gonadotropin-releasing hormone receptor


(Homo sapiens (Human))		BDBM50086623
PNG
(CHEMBL336039 | Trifluoro-acetate2-{2-[7-chloro-3-(...)
Show SMILES Cc1cc(C)cc(c1)-c1c(OCCC2CCCC[NH2+]2)c2cc(C(=O)Nc3cccnc3)c(Cl)cc2[nH]c1=O
Show InChI InChI=1S/C30H31ClN4O3/c1-18-12-19(2)14-20(13-18)27-28(38-11-8-21-6-3-4-10-33-21)24-15-23(25(31)16-26(24)35-30(27)37)29(36)34-22-7-5-9-32-17-22/h5,7,9,12-17,21,33H,3-4,6,8,10-11H2,1-2H3,(H,34,36)(H,35,37)/p+1
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibition of GnRH-stimulated phosphatidyl inositol hydrolysis in CHO cells stably expressing gonadotropin-releasing hormone receptor.

Bioorg Med Chem Lett 10: 443-7 (2000)


BindingDB Entry DOI: 10.7270/Q25Q4V99
More data for this
Ligand-Target Pair
Gonadotropin-releasing hormone receptor


(Homo sapiens (Human))		BDBM50086618
PNG
(CHEMBL139292 | Trifluoro-acetate2-{2-[7-chloro-3-(...)
Show SMILES COc1nccc(NC(=O)c2cc3c(OCCC4CCCC[NH2+]4)c(-c4cc(C)cc(C)c4)c(=O)[nH]c3cc2Cl)n1
Show InChI InChI=1S/C30H32ClN5O4/c1-17-12-18(2)14-19(13-17)26-27(40-11-8-20-6-4-5-9-32-20)22-15-21(23(31)16-24(22)34-29(26)38)28(37)35-25-7-10-33-30(36-25)39-3/h7,10,12-16,20,32H,4-6,8-9,11H2,1-3H3,(H,34,38)(H,33,35,36,37)/p+1
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibition of GnRH-stimulated phosphatidyl inositol hydrolysis in CHO cells stably expressing gonadotropin-releasing hormone receptor.

Bioorg Med Chem Lett 10: 443-7 (2000)


BindingDB Entry DOI: 10.7270/Q25Q4V99
More data for this
Ligand-Target Pair
Gonadotropin-releasing hormone receptor


(Rattus norvegicus)		BDBM50086627
PNG
(CHEMBL336884 | Trifluoro-acetate2-{2-[7-chloro-3-(...)
Show SMILES Cc1cc(C)cc(c1)-c1c(OCCC2CCCC[NH2+]2)c2cc(C(=O)Nc3cc(C)ncn3)c(Cl)cc2[nH]c1=O
Show InChI InChI=1S/C30H32ClN5O3/c1-17-10-18(2)12-20(11-17)27-28(39-9-7-21-6-4-5-8-32-21)23-14-22(24(31)15-25(23)35-30(27)38)29(37)36-26-13-19(3)33-16-34-26/h10-16,21,32H,4-9H2,1-3H3,(H,35,38)(H,33,34,36,37)/p+1
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibition of GnRH stimulated release of luteinizing hormone from the rat primary pituitary cells.

Bioorg Med Chem Lett 10: 443-7 (2000)


BindingDB Entry DOI: 10.7270/Q25Q4V99
More data for this
Ligand-Target Pair
Gonadotropin-releasing hormone receptor


(Homo sapiens (Human))		BDBM50086616
PNG
(CHEMBL343040 | Trifluoro-acetate2-{2-[7-chloro-6-d...)
Show SMILES CCN(CC)C(=O)c1cc2c(OCCC3CCCC[NH2+]3)c(-c3cc(C)cc(C)c3)c(=O)[nH]c2cc1Cl
Show InChI InChI=1S/C29H36ClN3O3/c1-5-33(6-2)29(35)22-16-23-25(17-24(22)30)32-28(34)26(20-14-18(3)13-19(4)15-20)27(23)36-12-10-21-9-7-8-11-31-21/h13-17,21,31H,5-12H2,1-4H3,(H,32,34)/p+1
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against rat CHO cells stably expressing human gonadotropin-releasing hormone receptor

Bioorg Med Chem Lett 10: 443-7 (2000)


BindingDB Entry DOI: 10.7270/Q25Q4V99
More data for this
Ligand-Target Pair
Gonadotropin-releasing hormone receptor


(Homo sapiens (Human))		BDBM50086615
PNG
(CHEMBL139291 | Trifluoro-acetate2-{2-[7-chloro-6-(...)
Show SMILES Cc1cc(C)cc(c1)-c1c(OCCC2CCCC[NH2+]2)c2cc(C(=O)Nc3ccnc(n3)C3CC3)c(Cl)cc2[nH]c1=O
Show InChI InChI=1S/C32H34ClN5O3/c1-18-13-19(2)15-21(14-18)28-29(41-12-9-22-5-3-4-10-34-22)24-16-23(25(33)17-26(24)36-32(28)40)31(39)38-27-8-11-35-30(37-27)20-6-7-20/h8,11,13-17,20,22,34H,3-7,9-10,12H2,1-2H3,(H,36,40)(H,35,37,38,39)/p+1
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibition of GnRH-stimulated phosphatidyl inositol hydrolysis in CHO cells stably expressing gonadotropin-releasing hormone receptor.

Bioorg Med Chem Lett 10: 443-7 (2000)


BindingDB Entry DOI: 10.7270/Q25Q4V99
More data for this
Ligand-Target Pair
Gonadotropin-releasing hormone receptor


(Homo sapiens (Human))		BDBM50086612
PNG
(CHEMBL342396 | Trifluoro-acetate2-{2-[7-chloro-3-(...)
Show SMILES Cc1cc(C)cc(c1)-c1c(OCCC2CCCC[NH2+]2)c2cc(C(=O)Nc3ncccn3)c(Cl)cc2[nH]c1=O
Show InChI InChI=1S/C29H30ClN5O3/c1-17-12-18(2)14-19(13-17)25-26(38-11-7-20-6-3-4-8-31-20)22-15-21(23(30)16-24(22)34-28(25)37)27(36)35-29-32-9-5-10-33-29/h5,9-10,12-16,20,31H,3-4,6-8,11H2,1-2H3,(H,34,37)(H,32,33,35,36)/p+1
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibition of GnRH-stimulated phosphatidyl inositol hydrolysis in CHO cells stably expressing gonadotropin-releasing hormone receptor.

Bioorg Med Chem Lett 10: 443-7 (2000)


BindingDB Entry DOI: 10.7270/Q25Q4V99
More data for this
Ligand-Target Pair
Gonadotropin-releasing hormone receptor


(Rattus norvegicus)		BDBM50086609
PNG
(CHEMBL342822 | Trifluoro-acetate2-{2-[7-chloro-3-(...)
Show SMILES Cc1cc(C)cc(c1)-c1c(OCCC2CCCC[NH2+]2)c2cc(C(=O)Nc3cnsn3)c(Cl)cc2[nH]c1=O
Show InChI InChI=1S/C27H28ClN5O3S/c1-15-9-16(2)11-17(10-15)24-25(36-8-6-18-5-3-4-7-29-18)20-12-19(21(28)13-22(20)31-27(24)35)26(34)32-23-14-30-37-33-23/h9-14,18,29H,3-8H2,1-2H3,(H,31,35)(H,32,33,34)/p+1
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibition of GnRH stimulated release of luteinizing hormone from the rat primary pituitary cells.

Bioorg Med Chem Lett 10: 443-7 (2000)


BindingDB Entry DOI: 10.7270/Q25Q4V99
More data for this
Ligand-Target Pair
Gonadotropin-releasing hormone receptor


(Homo sapiens (Human))		BDBM50086621
PNG
(CHEMBL141539 | Trifluoro-acetate2-{2-[7-chloro-3-(...)
Show SMILES Cc1cc(C)cc(c1)-c1c(OCCC2CCCC[NH2+]2)c2cc(C(=O)Nc3nc[nH]n3)c(Cl)cc2[nH]c1=O
Show InChI InChI=1S/C27H29ClN6O3/c1-15-9-16(2)11-17(10-15)23-24(37-8-6-18-5-3-4-7-29-18)20-12-19(21(28)13-22(20)32-26(23)36)25(35)33-27-30-14-31-34-27/h9-14,18,29H,3-8H2,1-2H3,(H,32,36)(H2,30,31,33,34,35)/p+1
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against rat CHO cells stably expressing human gonadotropin-releasing hormone receptor

Bioorg Med Chem Lett 10: 443-7 (2000)


BindingDB Entry DOI: 10.7270/Q25Q4V99
More data for this
Ligand-Target Pair
Gonadotropin-releasing hormone receptor


(Homo sapiens (Human))		BDBM50086611
PNG
(CHEMBL342908 | Trifluoro-acetate2-{2-[7-chloro-6-(...)
Show SMILES CN(C)c1ccc(NC(=O)c2cc3c(OCCC4CCCC[NH2+]4)c(-c4cc(C)cc(C)c4)c(=O)[nH]c3cc2Cl)cc1
Show InChI InChI=1S/C33H37ClN4O3/c1-20-15-21(2)17-22(16-20)30-31(41-14-12-23-7-5-6-13-35-23)27-18-26(28(34)19-29(27)37-33(30)40)32(39)36-24-8-10-25(11-9-24)38(3)4/h8-11,15-19,23,35H,5-7,12-14H2,1-4H3,(H,36,39)(H,37,40)/p+1
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibition of GnRH-stimulated phosphatidyl inositol hydrolysis in CHO cells stably expressing gonadotropin-releasing hormone receptor.

Bioorg Med Chem Lett 10: 443-7 (2000)


BindingDB Entry DOI: 10.7270/Q25Q4V99
More data for this
Ligand-Target Pair
Gonadotropin-releasing hormone receptor


(Homo sapiens (Human))		BDBM50086611
PNG
(CHEMBL342908 | Trifluoro-acetate2-{2-[7-chloro-6-(...)
Show SMILES CN(C)c1ccc(NC(=O)c2cc3c(OCCC4CCCC[NH2+]4)c(-c4cc(C)cc(C)c4)c(=O)[nH]c3cc2Cl)cc1
Show InChI InChI=1S/C33H37ClN4O3/c1-20-15-21(2)17-22(16-20)30-31(41-14-12-23-7-5-6-13-35-23)27-18-26(28(34)19-29(27)37-33(30)40)32(39)36-24-8-10-25(11-9-24)38(3)4/h8-11,15-19,23,35H,5-7,12-14H2,1-4H3,(H,36,39)(H,37,40)/p+1
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibition of GnRH-stimulated phosphatidyl inositol hydrolysis in CHO cells stably expressing gonadotropin-releasing hormone receptor.

Bioorg Med Chem Lett 10: 443-7 (2000)


BindingDB Entry DOI: 10.7270/Q25Q4V99
More data for this
Ligand-Target Pair
Gonadotropin-releasing hormone receptor


(Homo sapiens (Human))		BDBM50086622
PNG
(CHEMBL335764 | Trifluoro-acetate2-{2-[7-chloro-3-(...)
Show SMILES Cc1cc(C)cc(c1)-c1c(OCCC2CCCC[NH2+]2)c2cc(C(=O)Nc3cc(C)nc(C)n3)c(Cl)cc2[nH]c1=O
Show InChI InChI=1S/C31H34ClN5O3/c1-17-11-18(2)13-21(12-17)28-29(40-10-8-22-7-5-6-9-33-22)24-15-23(25(32)16-26(24)36-31(28)39)30(38)37-27-14-19(3)34-20(4)35-27/h11-16,22,33H,5-10H2,1-4H3,(H,36,39)(H,34,35,37,38)/p+1
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibition of GnRH-stimulated phosphatidyl inositol hydrolysis in CHO cells stably expressing gonadotropin-releasing hormone receptor.

Bioorg Med Chem Lett 10: 443-7 (2000)


BindingDB Entry DOI: 10.7270/Q25Q4V99
More data for this
Ligand-Target Pair
Gonadotropin-releasing hormone receptor


(Homo sapiens (Human))		BDBM50086622
PNG
(CHEMBL335764 | Trifluoro-acetate2-{2-[7-chloro-3-(...)
Show SMILES Cc1cc(C)cc(c1)-c1c(OCCC2CCCC[NH2+]2)c2cc(C(=O)Nc3cc(C)nc(C)n3)c(Cl)cc2[nH]c1=O
Show InChI InChI=1S/C31H34ClN5O3/c1-17-11-18(2)13-21(12-17)28-29(40-10-8-22-7-5-6-9-33-22)24-15-23(25(32)16-26(24)36-31(28)39)30(38)37-27-14-19(3)34-20(4)35-27/h11-16,22,33H,5-10H2,1-4H3,(H,36,39)(H,34,35,37,38)/p+1
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibition of GnRH-stimulated phosphatidyl inositol hydrolysis in CHO cells stably expressing gonadotropin-releasing hormone receptor.

Bioorg Med Chem Lett 10: 443-7 (2000)


BindingDB Entry DOI: 10.7270/Q25Q4V99
More data for this
Ligand-Target Pair
Gonadotropin-releasing hormone receptor


(Rattus norvegicus)		BDBM50086610
PNG
(CHEMBL139993 | Trifluoro-acetate2-{2-[7-chloro-3-(...)
Show SMILES Cc1cc(NC(=O)c2cc3c(OCCC4CCCC[NH2+]4)c(-c4cc(C)cc(C)c4)c(=O)[nH]c3cc2Cl)no1
Show InChI InChI=1S/C29H31ClN4O4/c1-16-10-17(2)12-19(11-16)26-27(37-9-7-20-6-4-5-8-31-20)22-14-21(23(30)15-24(22)32-29(26)36)28(35)33-25-13-18(3)38-34-25/h10-15,20,31H,4-9H2,1-3H3,(H,32,36)(H,33,34,35)/p+1
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibition of GnRH stimulated release of luteinizing hormone from the rat primary pituitary cells.

Bioorg Med Chem Lett 10: 443-7 (2000)


BindingDB Entry DOI: 10.7270/Q25Q4V99
More data for this
Ligand-Target Pair
Gonadotropin-releasing hormone receptor


(Rattus norvegicus)		BDBM50086625
PNG
(CHEMBL341717 | Trifluoro-acetate2-{2-[7-chloro-3-(...)
Show SMILES Cc1cc(NC(=O)c2cc3c(OCCC4CCCC[NH2+]4)c(-c4cc(C)cc(C)c4)c(=O)[nH]c3cc2Cl)sn1
Show InChI InChI=1S/C29H31ClN4O3S/c1-16-10-17(2)12-19(11-16)26-27(37-9-7-20-6-4-5-8-31-20)22-14-21(23(30)15-24(22)32-29(26)36)28(35)33-25-13-18(3)34-38-25/h10-15,20,31H,4-9H2,1-3H3,(H,32,36)(H,33,35)/p+1
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n/an/a 521n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibition of GnRH stimulated release of luteinizing hormone from the rat primary pituitary cells.

Bioorg Med Chem Lett 10: 443-7 (2000)


BindingDB Entry DOI: 10.7270/Q25Q4V99
More data for this
Ligand-Target Pair
Gonadotropin-releasing hormone receptor


(Homo sapiens (Human))		BDBM50086629
PNG
(CHEMBL141750 | Trifluoro-acetate2-{2-[6-[(benzo[1,...)
Show SMILES Cc1cc(C)cc(c1)-c1c(OCCC2CCCC[NH2+]2)c2cc(C(=O)NCc3ccc4OCOc4c3)c(Cl)cc2[nH]c1=O
Show InChI InChI=1S/C33H34ClN3O5/c1-19-11-20(2)13-22(12-19)30-31(40-10-8-23-5-3-4-9-35-23)25-15-24(26(34)16-27(25)37-33(30)39)32(38)36-17-21-6-7-28-29(14-21)42-18-41-28/h6-7,11-16,23,35H,3-5,8-10,17-18H2,1-2H3,(H,36,38)(H,37,39)/p+1
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n/an/a 591n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibition of GnRH-stimulated phosphatidyl inositol hydrolysis in CHO cells stably expressing gonadotropin-releasing hormone receptor.

Bioorg Med Chem Lett 10: 443-7 (2000)


BindingDB Entry DOI: 10.7270/Q25Q4V99
More data for this
Ligand-Target Pair
Gonadotropin-releasing hormone receptor


(Homo sapiens (Human))		BDBM50086621
PNG
(CHEMBL141539 | Trifluoro-acetate2-{2-[7-chloro-3-(...)
Show SMILES Cc1cc(C)cc(c1)-c1c(OCCC2CCCC[NH2+]2)c2cc(C(=O)Nc3nc[nH]n3)c(Cl)cc2[nH]c1=O
Show InChI InChI=1S/C27H29ClN6O3/c1-15-9-16(2)11-17(10-15)23-24(37-8-6-18-5-3-4-7-29-18)20-12-19(21(28)13-22(20)32-26(23)36)25(35)33-27-30-14-31-34-27/h9-14,18,29H,3-8H2,1-2H3,(H,32,36)(H2,30,31,33,34,35)/p+1
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n/an/a 775n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibition of GnRH-stimulated phosphatidyl inositol hydrolysis in CHO cells stably expressing gonadotropin-releasing hormone receptor.

Bioorg Med Chem Lett 10: 443-7 (2000)


BindingDB Entry DOI: 10.7270/Q25Q4V99
More data for this
Ligand-Target Pair
Gonadotropin-releasing hormone receptor


(Homo sapiens (Human))		BDBM50086606
PNG
(CHEMBL337323 | Trifluoro-acetate2-{2-[7-chloro-3-(...)
Show SMILES CCn1nccc1NC(=O)c1cc2c(OCCC3CCCC[NH2+]3)c(-c3cc(C)cc(C)c3)c(=O)[nH]c2cc1Cl
Show InChI InChI=1S/C30H34ClN5O3/c1-4-36-26(8-11-33-36)35-29(37)22-16-23-25(17-24(22)31)34-30(38)27(20-14-18(2)13-19(3)15-20)28(23)39-12-9-21-7-5-6-10-32-21/h8,11,13-17,21,32H,4-7,9-10,12H2,1-3H3,(H,34,38)(H,35,37)/p+1
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n/an/a 860n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against rat CHO cells stably expressing human gonadotropin-releasing hormone receptor

Bioorg Med Chem Lett 10: 443-7 (2000)


BindingDB Entry DOI: 10.7270/Q25Q4V99
More data for this
Ligand-Target Pair
Gonadotropin-releasing hormone receptor


(Homo sapiens (Human))		BDBM50086606
PNG
(CHEMBL337323 | Trifluoro-acetate2-{2-[7-chloro-3-(...)
Show SMILES CCn1nccc1NC(=O)c1cc2c(OCCC3CCCC[NH2+]3)c(-c3cc(C)cc(C)c3)c(=O)[nH]c2cc1Cl
Show InChI InChI=1S/C30H34ClN5O3/c1-4-36-26(8-11-33-36)35-29(37)22-16-23-25(17-24(22)31)34-30(38)27(20-14-18(2)13-19(3)15-20)28(23)39-12-9-21-7-5-6-10-32-21/h8,11,13-17,21,32H,4-7,9-10,12H2,1-3H3,(H,34,38)(H,35,37)/p+1
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n/an/a 977n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibition of GnRH-stimulated phosphatidyl inositol hydrolysis in CHO cells stably expressing gonadotropin-releasing hormone receptor.

Bioorg Med Chem Lett 10: 443-7 (2000)


BindingDB Entry DOI: 10.7270/Q25Q4V99
More data for this
Ligand-Target Pair
Gonadotropin-releasing hormone receptor


(Rattus norvegicus)		BDBM50086608
PNG
(CHEMBL343396 | Trifluoro-acetate2-{2-[7-chloro-3-(...)
Show SMILES Cc1cc(C)cc(c1)-c1c(OCCC2CCCC[NH2+]2)c2cc(C(=O)Nc3ccncc3)c(Cl)cc2[nH]c1=O
Show InChI InChI=1S/C30H31ClN4O3/c1-18-13-19(2)15-20(14-18)27-28(38-12-8-21-5-3-4-9-33-21)24-16-23(25(31)17-26(24)35-30(27)37)29(36)34-22-6-10-32-11-7-22/h6-7,10-11,13-17,21,33H,3-5,8-9,12H2,1-2H3,(H,35,37)(H,32,34,36)/p+1
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n/an/a 1.09E+3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibition of GnRH stimulated release of luteinizing hormone from the rat primary pituitary cells.

Bioorg Med Chem Lett 10: 443-7 (2000)


BindingDB Entry DOI: 10.7270/Q25Q4V99
More data for this
Ligand-Target Pair
Gonadotropin-releasing hormone receptor


(Rattus norvegicus)		BDBM50086613
PNG
(CHEMBL138999 | Trifluoro-acetate2-{2-[7-chloro-3-(...)
Show SMILES Cc1cc(C)cc(c1)-c1c(OCCC2CCCC[NH2+]2)c2cc(C(=O)Nc3ccccn3)c(Cl)cc2[nH]c1=O
Show InChI InChI=1S/C30H31ClN4O3/c1-18-13-19(2)15-20(14-18)27-28(38-12-9-21-7-3-5-10-32-21)23-16-22(24(31)17-25(23)34-30(27)37)29(36)35-26-8-4-6-11-33-26/h4,6,8,11,13-17,21,32H,3,5,7,9-10,12H2,1-2H3,(H,34,37)(H,33,35,36)/p+1
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n/an/a 1.27E+3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibition of GnRH stimulated release of luteinizing hormone from the rat primary pituitary cells.

Bioorg Med Chem Lett 10: 443-7 (2000)


BindingDB Entry DOI: 10.7270/Q25Q4V99
More data for this
Ligand-Target Pair
Gonadotropin-releasing hormone receptor


(Rattus norvegicus)		BDBM50086626
PNG
(CHEMBL334904 | Trifluoro-acetate2-{2-[7-chloro-3-(...)
Show SMILES Cc1nnc(NC(=O)c2cc3c(OCCC4CCCC[NH2+]4)c(-c4cc(C)cc(C)c4)c(=O)[nH]c3cc2Cl)s1
Show InChI InChI=1S/C28H30ClN5O3S/c1-15-10-16(2)12-18(11-15)24-25(37-9-7-19-6-4-5-8-30-19)21-13-20(22(29)14-23(21)31-27(24)36)26(35)32-28-34-33-17(3)38-28/h10-14,19,30H,4-9H2,1-3H3,(H,31,36)(H,32,34,35)/p+1
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n/an/a>1.28E+3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibition of GnRH stimulated release of luteinizing hormone from the rat primary pituitary cells.

Bioorg Med Chem Lett 10: 443-7 (2000)


BindingDB Entry DOI: 10.7270/Q25Q4V99
More data for this
Ligand-Target Pair
Gonadotropin-releasing hormone receptor


(Rattus norvegicus)		BDBM50086612
PNG
(CHEMBL342396 | Trifluoro-acetate2-{2-[7-chloro-3-(...)
Show SMILES Cc1cc(C)cc(c1)-c1c(OCCC2CCCC[NH2+]2)c2cc(C(=O)Nc3ncccn3)c(Cl)cc2[nH]c1=O
Show InChI InChI=1S/C29H30ClN5O3/c1-17-12-18(2)14-19(13-17)25-26(38-11-7-20-6-3-4-8-31-20)22-15-21(23(30)16-24(22)34-28(25)37)27(36)35-29-32-9-5-10-33-29/h5,9-10,12-16,20,31H,3-4,6-8,11H2,1-2H3,(H,34,37)(H,32,33,35,36)/p+1
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n/an/a>1.28E+3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against rat CHO cells stably expressing human gonadotropin-releasing hormone receptor

Bioorg Med Chem Lett 10: 443-7 (2000)


BindingDB Entry DOI: 10.7270/Q25Q4V99
More data for this
Ligand-Target Pair
Gonadotropin-releasing hormone receptor


(Rattus norvegicus)		BDBM50086621
PNG
(CHEMBL141539 | Trifluoro-acetate2-{2-[7-chloro-3-(...)
Show SMILES Cc1cc(C)cc(c1)-c1c(OCCC2CCCC[NH2+]2)c2cc(C(=O)Nc3nc[nH]n3)c(Cl)cc2[nH]c1=O
Show InChI InChI=1S/C27H29ClN6O3/c1-15-9-16(2)11-17(10-15)23-24(37-8-6-18-5-3-4-7-29-18)20-12-19(21(28)13-22(20)32-26(23)36)25(35)33-27-30-14-31-34-27/h9-14,18,29H,3-8H2,1-2H3,(H,32,36)(H2,30,31,33,34,35)/p+1
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n/an/a>1.28E+3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibition of GnRH stimulated release of luteinizing hormone from the rat primary pituitary cells.

Bioorg Med Chem Lett 10: 443-7 (2000)


BindingDB Entry DOI: 10.7270/Q25Q4V99
More data for this
Ligand-Target Pair
Gonadotropin-releasing hormone receptor


(Rattus norvegicus)		BDBM50086616
PNG
(CHEMBL343040 | Trifluoro-acetate2-{2-[7-chloro-6-d...)
Show SMILES CCN(CC)C(=O)c1cc2c(OCCC3CCCC[NH2+]3)c(-c3cc(C)cc(C)c3)c(=O)[nH]c2cc1Cl
Show InChI InChI=1S/C29H36ClN3O3/c1-5-33(6-2)29(35)22-16-23-25(17-24(22)30)32-28(34)26(20-14-18(3)13-19(4)15-20)27(23)36-12-10-21-9-7-8-11-31-21/h13-17,21,31H,5-12H2,1-4H3,(H,32,34)/p+1
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n/an/a>1.28E+3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibition of GnRH stimulated release of luteinizing hormone from the rat primary pituitary cells.

Bioorg Med Chem Lett 10: 443-7 (2000)


BindingDB Entry DOI: 10.7270/Q25Q4V99
More data for this
Ligand-Target Pair
Gonadotropin-releasing hormone receptor


(Rattus norvegicus)		BDBM50086628
PNG
(CHEMBL344688 | Trifluoro-acetate2-{2-[7-chloro-3-(...)
Show SMILES Cc1cc(NC(=O)c2cc3c(OCCC4CCCC[NH2+]4)c(-c4cc(C)cc(C)c4)c(=O)[nH]c3cc2Cl)on1
Show InChI InChI=1S/C29H31ClN4O4/c1-16-10-17(2)12-19(11-16)26-27(37-9-7-20-6-4-5-8-31-20)22-14-21(23(30)15-24(22)32-29(26)36)28(35)33-25-13-18(3)34-38-25/h10-15,20,31H,4-9H2,1-3H3,(H,32,36)(H,33,35)/p+1
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n/an/a>1.28E+3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against rat CHO cells stably expressing human gonadotropin-releasing hormone receptor

Bioorg Med Chem Lett 10: 443-7 (2000)


BindingDB Entry DOI: 10.7270/Q25Q4V99
More data for this
Ligand-Target Pair
Gonadotropin-releasing hormone receptor


(Rattus norvegicus)		BDBM50086619
PNG
(CHEMBL138977 | Trifluoro-acetate2-{2-[7-chloro-6-(...)
Show SMILES CCC(C)N(C(C)CC)C(=O)c1cc2c(OCCC3CCCC[NH2+]3)c(-c3cc(C)cc(C)c3)c(=O)[nH]c2cc1Cl
Show InChI InChI=1S/C33H44ClN3O3/c1-7-22(5)37(23(6)8-2)33(39)26-18-27-29(19-28(26)34)36-32(38)30(24-16-20(3)15-21(4)17-24)31(27)40-14-12-25-11-9-10-13-35-25/h15-19,22-23,25,35H,7-14H2,1-6H3,(H,36,38)/p+1
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n/an/a>1.28E+3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against rat CHO cells stably expressing human gonadotropin-releasing hormone receptor

Bioorg Med Chem Lett 10: 443-7 (2000)


BindingDB Entry DOI: 10.7270/Q25Q4V99
More data for this
Ligand-Target Pair
Gonadotropin-releasing hormone receptor


(Rattus norvegicus)		BDBM50086629
PNG
(CHEMBL141750 | Trifluoro-acetate2-{2-[6-[(benzo[1,...)
Show SMILES Cc1cc(C)cc(c1)-c1c(OCCC2CCCC[NH2+]2)c2cc(C(=O)NCc3ccc4OCOc4c3)c(Cl)cc2[nH]c1=O
Show InChI InChI=1S/C33H34ClN3O5/c1-19-11-20(2)13-22(12-19)30-31(40-10-8-23-5-3-4-9-35-23)25-15-24(26(34)16-27(25)37-33(30)39)32(38)36-17-21-6-7-28-29(14-21)42-18-41-28/h6-7,11-16,23,35H,3-5,8-10,17-18H2,1-2H3,(H,36,38)(H,37,39)/p+1
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibition of GnRH stimulated release of luteinizing hormone from the rat primary pituitary cells.

Bioorg Med Chem Lett 10: 443-7 (2000)


BindingDB Entry DOI: 10.7270/Q25Q4V99
More data for this
Ligand-Target Pair
Gonadotropin-releasing hormone receptor


(Rattus norvegicus)		BDBM50086623
PNG
(CHEMBL336039 | Trifluoro-acetate2-{2-[7-chloro-3-(...)
Show SMILES Cc1cc(C)cc(c1)-c1c(OCCC2CCCC[NH2+]2)c2cc(C(=O)Nc3cccnc3)c(Cl)cc2[nH]c1=O
Show InChI InChI=1S/C30H31ClN4O3/c1-18-12-19(2)14-20(13-18)27-28(38-11-8-21-6-3-4-10-33-21)24-15-23(25(31)16-26(24)35-30(27)37)29(36)34-22-7-5-9-32-17-22/h5,7,9,12-17,21,33H,3-4,6,8,10-11H2,1-2H3,(H,34,36)(H,35,37)/p+1
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n/an/a>1.28E+3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibition of GnRH stimulated release of luteinizing hormone from the rat primary pituitary cells.

Bioorg Med Chem Lett 10: 443-7 (2000)


BindingDB Entry DOI: 10.7270/Q25Q4V99
More data for this
Ligand-Target Pair
Gonadotropin-releasing hormone receptor


(Homo sapiens (Human))		BDBM50086612
PNG
(CHEMBL342396 | Trifluoro-acetate2-{2-[7-chloro-3-(...)
Show SMILES Cc1cc(C)cc(c1)-c1c(OCCC2CCCC[NH2+]2)c2cc(C(=O)Nc3ncccn3)c(Cl)cc2[nH]c1=O
Show InChI InChI=1S/C29H30ClN5O3/c1-17-12-18(2)14-19(13-17)25-26(38-11-7-20-6-3-4-8-31-20)22-15-21(23(30)16-24(22)34-28(25)37)27(36)35-29-32-9-5-10-33-29/h5,9-10,12-16,20,31H,3-4,6-8,11H2,1-2H3,(H,34,37)(H,32,33,35,36)/p+1
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n/an/a>3.20E+3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibition of GnRH-stimulated phosphatidyl inositol hydrolysis in CHO cells stably expressing gonadotropin-releasing hormone receptor.

Bioorg Med Chem Lett 10: 443-7 (2000)


BindingDB Entry DOI: 10.7270/Q25Q4V99
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%