| Reaction Details |
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 | Report a problem with these data |
| Target | Gonadotropin-releasing hormone receptor |
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| Ligand | BDBM50086607 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_71309 (CHEMBL686112) |
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| IC50 | 8.3±n/a nM |
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| Citation |  Walsh, TF; Toupence, RB; Young, JR; Huang, SX; Ujjainwalla, F; DeVita, RJ; Goulet, MT; Wyvratt, MJ; Fisher, MH; Lo, JL; Ren, N; Yudkovitz, JB; Yang, YT; Cheng, K; Smith, RG Potent antagonists of gonadotropin releasing hormone receptors derived from quinolone-6-carboxamides. Bioorg Med Chem Lett10:443-7 (2000) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Gonadotropin-releasing hormone receptor |
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| Name: | Gonadotropin-releasing hormone receptor |
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| Synonyms: | GNRHR | GNRHR_HUMAN | GRHR | GnRH receptor | GnRH-R | Gonadotropin releasing hormone 1 (GnRHR1) | Gonadotropin-releasing hormone receptor | Gonadotropin-releasing hormone receptor (GnRH) |
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| Type: | Enzyme |
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| Mol. Mass.: | 37749.45 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P30968 |
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| Residue: | 328 |
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| Sequence: | MANSASPEQNQNHCSAINNSIPLMQGNLPTLTLSGKIRVTVTFFLFLLSATFNASFLLKL
QKWTQKKEKGKKLSRMKLLLKHLTLANLLETLIVMPLDGMWNITVQWYAGELLCKVLSYL
KLFSMYAPAFMMVVISLDRSLAITRPLALKSNSKVGQSMVGLAWILSSVFAGPQLYIFRM
IHLADSSGQTKVFSQCVTHCSFSQWWHQAFYNFFTFSCLFIIPLFIMLICNAKIIFTLTR
VLHQDPHELQLNQSKNNIPRARLKTLKMTVAFATSFTVCWTPYYVLGIWYWFDPEMLNRL
SDPVNHFFFLFAFLNPCFDPLIYGYFSL
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| BDBM50086607 |
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| n/a |
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| Name | BDBM50086607 |
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| Synonyms: | CHEMBL341809 | Trifluoro-acetate2-{2-[7-chloro-3-(3,5-dimethyl-phenyl)-2-oxo-6-(pyrimidin-4-ylcarbamoyl)-1,2-dihydro-quinolin-4-yloxy]-ethyl}-piperidinium; |
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| Type | Small organic molecule |
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| Emp. Form. | C29H31ClN5O3 |
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| Mol. Mass. | 533.041 |
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| SMILES | Cc1cc(C)cc(c1)-c1c(OCCC2CCCC[NH2+]2)c2cc(C(=O)Nc3ccncn3)c(Cl)cc2[nH]c1=O |
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| Structure | 
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