| Reaction Details |
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 | Report a problem with these data |
| Target | Gonadotropin-releasing hormone receptor |
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| Ligand | BDBM50086609 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_71423 |
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| IC50 | 292±n/a nM |
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| Citation |  Walsh, TF; Toupence, RB; Young, JR; Huang, SX; Ujjainwalla, F; DeVita, RJ; Goulet, MT; Wyvratt, MJ; Fisher, MH; Lo, JL; Ren, N; Yudkovitz, JB; Yang, YT; Cheng, K; Smith, RG Potent antagonists of gonadotropin releasing hormone receptors derived from quinolone-6-carboxamides. Bioorg Med Chem Lett10:443-7 (2000) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Gonadotropin-releasing hormone receptor |
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| Name: | Gonadotropin-releasing hormone receptor |
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| Synonyms: | GNRHR_RAT | GnRH receptor | GnRH-R | Gnrhr |
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| Type: | PROTEIN |
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| Mol. Mass.: | 37767.60 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_1335047 |
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| Residue: | 327 |
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| Sequence: | MANNASLEQDQNHCSAINNSIPLTQGKLPTLTLSGKIRVTVTFFLFLLSTAFNASFLVKL
QRWTQKRKKGKKLSRMKVLLKHLTLANLLETLIVMPLDGMWNITVQWYAGEFLCKVLSYL
KLFSMYAPAFMMVVISLDRSLAVTQPLAVQSKSKLERSMTSLAWILSIVFAGPQLYIFRM
IYLADGSGPAVFSQCVTHCSFPQWWHEAFYNFFTFSCLFIIPLLIMLICNAKIIFALTRV
LHQDPRKLQLNQSKNNIPRARLRTLKMTVAFGTSFVICWTPYYVLGIWYWFDPEMLNRVS
EPVNHFFFLFAFLNPCFDPLIYGYFSL
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| BDBM50086609 |
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| n/a |
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| Name | BDBM50086609 |
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| Synonyms: | CHEMBL342822 | Trifluoro-acetate2-{2-[7-chloro-3-(3,5-dimethyl-phenyl)-2-oxo-6-([1,2,5]thiadiazol-3-ylcarbamoyl)-1,2-dihydro-quinolin-4-yloxy]-ethyl}-piperidinium; |
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| Type | Small organic molecule |
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| Emp. Form. | C27H29ClN5O3S |
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| Mol. Mass. | 539.068 |
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| SMILES | Cc1cc(C)cc(c1)-c1c(OCCC2CCCC[NH2+]2)c2cc(C(=O)Nc3cnsn3)c(Cl)cc2[nH]c1=O |
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| Structure | 
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