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PubMed code 10937724

Compile data set for download or QSAR
Found 56 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Sodium-dependent dopamine transporter


(Rattus norvegicus (rat))		BDBM50090495
PNG
((R)-4-(4-Chloro-phenyl)-1-aza-bicyclo[3.2.1]octan-...)
Show SMILES Clc1ccc(cc1)[C@@H]1CCN2CC1\C(C2)=N\OCCCc1ccccc1 |TLB:15:13:11:7.8.9,THB:4:7:11:13.14|
Show InChI InChI=1S/C22H25ClN2O/c23-19-10-8-18(9-11-19)20-12-13-25-15-21(20)22(16-25)24-26-14-4-7-17-5-2-1-3-6-17/h1-3,5-6,8-11,20-21H,4,7,12-16H2/b24-22+/t20-,21?/m0/s1
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 41n/an/an/an/an/an/an/an/a



Georgetown University Medical Center

Curated by ChEMBL


Assay Description
Inhibition of [3H]DA binding to dopamine transporter of rat brain synaptosomes

Bioorg Med Chem Lett 10: 1681-6 (2000)


BindingDB Entry DOI: 10.7270/Q2MG7Q0C
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Rattus norvegicus (rat))		BDBM50090499
PNG
(4-(4-Chloro-phenyl)-1-methyl-piperidine-3-carboxyl...)
Show SMILES CN1CCC(C(C1)C(=O)OCCCCCc1ccccc1)c1ccc(Cl)cc1
Show InChI InChI=1S/C24H30ClNO2/c1-26-16-15-22(20-11-13-21(25)14-12-20)23(18-26)24(27)28-17-7-3-6-10-19-8-4-2-5-9-19/h2,4-5,8-9,11-14,22-23H,3,6-7,10,15-18H2,1H3
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 52n/an/an/an/an/an/an/an/a



Georgetown University Medical Center

Curated by ChEMBL


Assay Description
Inhibition of [3H]- Mazindol binding to dopamine transporter of rat striatal membrane.

Bioorg Med Chem Lett 10: 1681-6 (2000)


BindingDB Entry DOI: 10.7270/Q2MG7Q0C
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Rattus norvegicus (rat))		BDBM50090499
PNG
(4-(4-Chloro-phenyl)-1-methyl-piperidine-3-carboxyl...)
Show SMILES CN1CCC(C(C1)C(=O)OCCCCCc1ccccc1)c1ccc(Cl)cc1
Show InChI InChI=1S/C24H30ClNO2/c1-26-16-15-22(20-11-13-21(25)14-12-20)23(18-26)24(27)28-17-7-3-6-10-19-8-4-2-5-9-19/h2,4-5,8-9,11-14,22-23H,3,6-7,10,15-18H2,1H3
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 53n/an/an/an/an/an/an/an/a



Georgetown University Medical Center

Curated by ChEMBL


Assay Description
Inhibition of [3H]DA binding to dopamine transporter of rat brain synaptosomes

Bioorg Med Chem Lett 10: 1681-6 (2000)


BindingDB Entry DOI: 10.7270/Q2MG7Q0C
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Rattus norvegicus (rat))		BDBM50090495
PNG
((R)-4-(4-Chloro-phenyl)-1-aza-bicyclo[3.2.1]octan-...)
Show SMILES Clc1ccc(cc1)[C@@H]1CCN2CC1\C(C2)=N\OCCCc1ccccc1 |TLB:15:13:11:7.8.9,THB:4:7:11:13.14|
Show InChI InChI=1S/C22H25ClN2O/c23-19-10-8-18(9-11-19)20-12-13-25-15-21(20)22(16-25)24-26-14-4-7-17-5-2-1-3-6-17/h1-3,5-6,8-11,20-21H,4,7,12-16H2/b24-22+/t20-,21?/m0/s1
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 53n/an/an/an/an/an/an/an/a



Georgetown University Medical Center

Curated by ChEMBL


Assay Description
Inhibition of [3H]-5-HT binding to serotonin transporter of rat brain synaptosomes

Bioorg Med Chem Lett 10: 1681-6 (2000)


BindingDB Entry DOI: 10.7270/Q2MG7Q0C
More data for this
Ligand-Target Pair
Transporter


(Rattus norvegicus)		BDBM50090500
PNG
(4-(4-Chloro-phenyl)-1-methyl-piperidine-3-carboxyl...)
Show SMILES CN1CCC(C(C1)C(=O)OCCCc1ccccc1)c1ccc(Cl)cc1
Show InChI InChI=1S/C22H26ClNO2/c1-24-14-13-20(18-9-11-19(23)12-10-18)21(16-24)22(25)26-15-5-8-17-6-3-2-4-7-17/h2-4,6-7,9-12,20-21H,5,8,13-16H2,1H3
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 72n/an/an/an/an/an/an/an/a



Georgetown University Medical Center

Curated by ChEMBL


Assay Description
Inhibition of [3H]NE binding to norepinephrine transporter of rat brain synaptosomes

Bioorg Med Chem Lett 10: 1681-6 (2000)


BindingDB Entry DOI: 10.7270/Q2MG7Q0C
More data for this
Ligand-Target Pair
Transporter


(Rattus norvegicus)		BDBM50090493
PNG
(4-(4-Chloro-phenyl)-1-methyl-piperidine-3-carboxyl...)
Show SMILES COC(=O)C1CN(C)CCC1c1ccc(Cl)cc1
Show InChI InChI=1S/C14H18ClNO2/c1-16-8-7-12(13(9-16)14(17)18-2)10-3-5-11(15)6-4-10/h3-6,12-13H,7-9H2,1-2H3
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 90n/an/an/an/an/an/an/an/a



Georgetown University Medical Center

Curated by ChEMBL


Assay Description
Inhibition of [3H]NE binding to norepinephrine transporter of rat brain synaptosomes

Bioorg Med Chem Lett 10: 1681-6 (2000)


BindingDB Entry DOI: 10.7270/Q2MG7Q0C
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Rattus norvegicus (rat))		BDBM50090491
PNG
((R)-4-(4-Chloro-phenyl)-1-aza-bicyclo[3.2.1]octan-...)
Show SMILES Clc1ccc(cc1)[C@@H]1CCN2CC1\C(C2)=N\OCc1ccccc1 |TLB:15:13:11:7.8.9,THB:4:7:11:13.14|
Show InChI InChI=1S/C20H21ClN2O/c21-17-8-6-16(7-9-17)18-10-11-23-12-19(18)20(13-23)22-24-14-15-4-2-1-3-5-15/h1-9,18-19H,10-14H2/b22-20+/t18-,19?/m0/s1
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 117n/an/an/an/an/an/an/an/a



Georgetown University Medical Center

Curated by ChEMBL


Assay Description
Inhibition of [3H]-5-HT binding to serotonin transporter of rat brain synaptosomes

Bioorg Med Chem Lett 10: 1681-6 (2000)


BindingDB Entry DOI: 10.7270/Q2MG7Q0C
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Rattus norvegicus (rat))		BDBM50090496
PNG
((R)-4-(4-Chloro-phenyl)-1-aza-bicyclo[3.2.1]octan-...)
Show SMILES CC(C)(C)O\N=C1/CN2CC1[C@@H](CC2)c1ccc(Cl)cc1 |TLB:14:11:9:6.7,THB:5:6:9:11.12.13|
Show InChI InChI=1S/C17H23ClN2O/c1-17(2,3)21-19-16-11-20-9-8-14(15(16)10-20)12-4-6-13(18)7-5-12/h4-7,14-15H,8-11H2,1-3H3/b19-16+/t14-,15?/m0/s1
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 137n/an/an/an/an/an/an/an/a



Georgetown University Medical Center

Curated by ChEMBL


Assay Description
Inhibition of [3H]-5-HT binding to serotonin transporter of rat brain synaptosomes

Bioorg Med Chem Lett 10: 1681-6 (2000)


BindingDB Entry DOI: 10.7270/Q2MG7Q0C
More data for this
Ligand-Target Pair
Transporter


(Rattus norvegicus)		BDBM22418
PNG
(Cocaine | Cocaine (-) | methyl (1R,2R,3S,5S)-3-(be...)
Show SMILES [H][C@]12CC[C@]([H])([C@H]([C@H](C1)OC(=O)c1ccccc1)C(=O)OC)N2C |TLB:18:6:22:3.2|
Show InChI InChI=1S/C17H21NO4/c1-18-12-8-9-13(18)15(17(20)21-2)14(10-12)22-16(19)11-6-4-3-5-7-11/h3-7,12-15H,8-10H2,1-2H3/t12-,13+,14-,15+/m0/s1
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 186n/an/an/an/an/an/an/an/a



Georgetown University Medical Center

Curated by ChEMBL


Assay Description
Inhibition of [3H]DA binding to dopamine transporter of rat brain synaptosomes

Bioorg Med Chem Lett 10: 1681-6 (2000)


BindingDB Entry DOI: 10.7270/Q2MG7Q0C
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Rattus norvegicus (rat))		BDBM50090493
PNG
(4-(4-Chloro-phenyl)-1-methyl-piperidine-3-carboxyl...)
Show SMILES COC(=O)C1CN(C)CCC1c1ccc(Cl)cc1
Show InChI InChI=1S/C14H18ClNO2/c1-16-8-7-12(13(9-16)14(17)18-2)10-3-5-11(15)6-4-10/h3-6,12-13H,7-9H2,1-2H3
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 228n/an/an/an/an/an/an/an/a



Georgetown University Medical Center

Curated by ChEMBL


Assay Description
Inhibition of [3H]DA binding to dopamine transporter of rat brain synaptosomes

Bioorg Med Chem Lett 10: 1681-6 (2000)


BindingDB Entry DOI: 10.7270/Q2MG7Q0C
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Rattus norvegicus (rat))		BDBM22418
PNG
(Cocaine | Cocaine (-) | methyl (1R,2R,3S,5S)-3-(be...)
Show SMILES [H][C@]12CC[C@]([H])([C@H]([C@H](C1)OC(=O)c1ccccc1)C(=O)OC)N2C |TLB:18:6:22:3.2|
Show InChI InChI=1S/C17H21NO4/c1-18-12-8-9-13(18)15(17(20)21-2)14(10-12)22-16(19)11-6-4-3-5-7-11/h3-7,12-15H,8-10H2,1-2H3/t12-,13+,14-,15+/m0/s1
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 230n/an/an/an/an/an/an/an/a



Georgetown University Medical Center

Curated by ChEMBL


Assay Description
Inhibition of [3H]- Mazindol binding to dopamine transporter of rat striatal membrane.

Bioorg Med Chem Lett 10: 1681-6 (2000)


BindingDB Entry DOI: 10.7270/Q2MG7Q0C
More data for this
Ligand-Target Pair
Transporter


(Rattus norvegicus)		BDBM50090494
PNG
((R)-4-(4-Chloro-phenyl)-1-aza-bicyclo[3.2.1]octan-...)
Show SMILES CO\N=C1\CN2CC1[C@@H](CC2)c1ccc(Cl)cc1
Show InChI InChI=1S/C14H17ClN2O/c1-18-16-14-9-17-7-6-12(13(14)8-17)10-2-4-11(15)5-3-10/h2-5,12-13H,6-9H2,1H3/b16-14-/t12-,13?/m0/s1
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 232n/an/an/an/an/an/an/an/a



Georgetown University Medical Center

Curated by ChEMBL


Assay Description
Inhibition of [3H]NE binding to norepinephrine transporter of rat brain synaptosomes

Bioorg Med Chem Lett 10: 1681-6 (2000)


BindingDB Entry DOI: 10.7270/Q2MG7Q0C
More data for this
Ligand-Target Pair
Transporter


(Rattus norvegicus)		BDBM50090492
PNG
((S)-4-(4-Chloro-phenyl)-1-aza-bicyclo[3.2.1]octan-...)
Show SMILES CO\N=C1\CN2CC1[C@H](CC2)c1ccc(Cl)cc1 |THB:11:8:6:3.4|
Show InChI InChI=1S/C14H17ClN2O/c1-18-16-14-9-17-7-6-12(13(14)8-17)10-2-4-11(15)5-3-10/h2-5,12-13H,6-9H2,1H3/b16-14-/t12-,13?/m1/s1
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 240n/an/an/an/an/an/an/an/a



Georgetown University Medical Center

Curated by ChEMBL


Assay Description
Inhibition of [3H]NE binding to norepinephrine transporter of rat brain synaptosomes

Bioorg Med Chem Lett 10: 1681-6 (2000)


BindingDB Entry DOI: 10.7270/Q2MG7Q0C
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Rattus norvegicus (rat))		BDBM50090493
PNG
(4-(4-Chloro-phenyl)-1-methyl-piperidine-3-carboxyl...)
Show SMILES COC(=O)C1CN(C)CCC1c1ccc(Cl)cc1
Show InChI InChI=1S/C14H18ClNO2/c1-16-8-7-12(13(9-16)14(17)18-2)10-3-5-11(15)6-4-10/h3-6,12-13H,7-9H2,1-2H3
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 248n/an/an/an/an/an/an/an/a



Georgetown University Medical Center

Curated by ChEMBL


Assay Description
Inhibition of [3H]DA binding to dopamine transporter of rat brain synaptosomes

Bioorg Med Chem Lett 10: 1681-6 (2000)


BindingDB Entry DOI: 10.7270/Q2MG7Q0C
More data for this
Ligand-Target Pair
Transporter


(Rattus norvegicus)		BDBM50090496
PNG
((R)-4-(4-Chloro-phenyl)-1-aza-bicyclo[3.2.1]octan-...)
Show SMILES CC(C)(C)O\N=C1/CN2CC1[C@@H](CC2)c1ccc(Cl)cc1 |TLB:14:11:9:6.7,THB:5:6:9:11.12.13|
Show InChI InChI=1S/C17H23ClN2O/c1-17(2,3)21-19-16-11-20-9-8-14(15(16)10-20)12-4-6-13(18)7-5-12/h4-7,14-15H,8-11H2,1-3H3/b19-16+/t14-,15?/m0/s1
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 287n/an/an/an/an/an/an/an/a



Georgetown University Medical Center

Curated by ChEMBL


Assay Description
Inhibition of [3H]NE binding to norepinephrine transporter of rat brain synaptosomes

Bioorg Med Chem Lett 10: 1681-6 (2000)


BindingDB Entry DOI: 10.7270/Q2MG7Q0C
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Rattus norvegicus (rat))		BDBM50090495
PNG
((R)-4-(4-Chloro-phenyl)-1-aza-bicyclo[3.2.1]octan-...)
Show SMILES Clc1ccc(cc1)[C@@H]1CCN2CC1\C(C2)=N\OCCCc1ccccc1 |TLB:15:13:11:7.8.9,THB:4:7:11:13.14|
Show InChI InChI=1S/C22H25ClN2O/c23-19-10-8-18(9-11-19)20-12-13-25-15-21(20)22(16-25)24-26-14-4-7-17-5-2-1-3-6-17/h1-3,5-6,8-11,20-21H,4,7,12-16H2/b24-22+/t20-,21?/m0/s1
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 292n/an/an/an/an/an/an/an/a



Georgetown University Medical Center

Curated by ChEMBL


Assay Description
Inhibition of [3H]-5-HT binding to serotonin transporter of rat brain synaptosomes

Bioorg Med Chem Lett 10: 1681-6 (2000)


BindingDB Entry DOI: 10.7270/Q2MG7Q0C
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Rattus norvegicus (rat))		BDBM50090492
PNG
((S)-4-(4-Chloro-phenyl)-1-aza-bicyclo[3.2.1]octan-...)
Show SMILES CO\N=C1\CN2CC1[C@H](CC2)c1ccc(Cl)cc1 |THB:11:8:6:3.4|
Show InChI InChI=1S/C14H17ClN2O/c1-18-16-14-9-17-7-6-12(13(14)8-17)10-2-4-11(15)5-3-10/h2-5,12-13H,6-9H2,1H3/b16-14-/t12-,13?/m1/s1
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 292n/an/an/an/an/an/an/an/a



Georgetown University Medical Center

Curated by ChEMBL


Assay Description
Inhibition of [3H]DA binding to dopamine transporter of rat brain synaptosomes

Bioorg Med Chem Lett 10: 1681-6 (2000)


BindingDB Entry DOI: 10.7270/Q2MG7Q0C
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Rattus norvegicus (rat))		BDBM22418
PNG
(Cocaine | Cocaine (-) | methyl (1R,2R,3S,5S)-3-(be...)
Show SMILES [H][C@]12CC[C@]([H])([C@H]([C@H](C1)OC(=O)c1ccccc1)C(=O)OC)N2C |TLB:18:6:22:3.2|
Show InChI InChI=1S/C17H21NO4/c1-18-12-8-9-13(18)15(17(20)21-2)14(10-12)22-16(19)11-6-4-3-5-7-11/h3-7,12-15H,8-10H2,1-2H3/t12-,13+,14-,15+/m0/s1
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 301n/an/an/an/an/an/an/an/a



Georgetown University Medical Center

Curated by ChEMBL


Assay Description
Inhibition of [3H]DA binding to dopamine transporter of rat brain synaptosomes

Bioorg Med Chem Lett 10: 1681-6 (2000)


BindingDB Entry DOI: 10.7270/Q2MG7Q0C
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Rattus norvegicus (rat))		BDBM50090494
PNG
((R)-4-(4-Chloro-phenyl)-1-aza-bicyclo[3.2.1]octan-...)
Show SMILES CO\N=C1\CN2CC1[C@@H](CC2)c1ccc(Cl)cc1
Show InChI InChI=1S/C14H17ClN2O/c1-18-16-14-9-17-7-6-12(13(14)8-17)10-2-4-11(15)5-3-10/h2-5,12-13H,6-9H2,1H3/b16-14-/t12-,13?/m0/s1
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 304n/an/an/an/an/an/an/an/a



Georgetown University Medical Center

Curated by ChEMBL


Assay Description
Inhibition of [3H]DA binding to dopamine transporter of rat brain synaptosomes

Bioorg Med Chem Lett 10: 1681-6 (2000)


BindingDB Entry DOI: 10.7270/Q2MG7Q0C
More data for this
Ligand-Target Pair
Transporter


(Rattus norvegicus)		BDBM50090497
PNG
((S)-4-(4-Chloro-phenyl)-1-aza-bicyclo[3.2.1]octan-...)
Show SMILES CO\N=C1/CN2CC1[C@H](CC2)c1ccc(Cl)cc1
Show InChI InChI=1S/C14H17ClN2O/c1-18-16-14-9-17-7-6-12(13(14)8-17)10-2-4-11(15)5-3-10/h2-5,12-13H,6-9H2,1H3/b16-14+/t12-,13?/m1/s1
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 305n/an/an/an/an/an/an/an/a



Georgetown University Medical Center

Curated by ChEMBL


Assay Description
Inhibition of [3H]NE binding to norepinephrine transporter of rat brain synaptosomes

Bioorg Med Chem Lett 10: 1681-6 (2000)


BindingDB Entry DOI: 10.7270/Q2MG7Q0C
More data for this
Ligand-Target Pair
Transporter


(Rattus norvegicus)		BDBM50090497
PNG
((S)-4-(4-Chloro-phenyl)-1-aza-bicyclo[3.2.1]octan-...)
Show SMILES CO\N=C1/CN2CC1[C@H](CC2)c1ccc(Cl)cc1
Show InChI InChI=1S/C14H17ClN2O/c1-18-16-14-9-17-7-6-12(13(14)8-17)10-2-4-11(15)5-3-10/h2-5,12-13H,6-9H2,1H3/b16-14+/t12-,13?/m1/s1
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 305n/an/an/an/an/an/an/an/a



Georgetown University Medical Center

Curated by ChEMBL


Assay Description
Inhibition of [3H]- Mazindol binding to dopamine transporter of rat striatal membrane.

Bioorg Med Chem Lett 10: 1681-6 (2000)


BindingDB Entry DOI: 10.7270/Q2MG7Q0C
More data for this
Ligand-Target Pair
Transporter


(Rattus norvegicus)		BDBM50090499
PNG
(4-(4-Chloro-phenyl)-1-methyl-piperidine-3-carboxyl...)
Show SMILES CN1CCC(C(C1)C(=O)OCCCCCc1ccccc1)c1ccc(Cl)cc1
Show InChI InChI=1S/C24H30ClNO2/c1-26-16-15-22(20-11-13-21(25)14-12-20)23(18-26)24(27)28-17-7-3-6-10-19-8-4-2-5-9-19/h2,4-5,8-9,11-14,22-23H,3,6-7,10,15-18H2,1H3
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 382n/an/an/an/an/an/an/an/a



Georgetown University Medical Center

Curated by ChEMBL


Assay Description
Inhibition of [3H]NE binding to norepinephrine transporter of rat brain synaptosomes

Bioorg Med Chem Lett 10: 1681-6 (2000)


BindingDB Entry DOI: 10.7270/Q2MG7Q0C
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Rattus norvegicus (rat))		BDBM22418
PNG
(Cocaine | Cocaine (-) | methyl (1R,2R,3S,5S)-3-(be...)
Show SMILES [H][C@]12CC[C@]([H])([C@H]([C@H](C1)OC(=O)c1ccccc1)C(=O)OC)N2C |TLB:18:6:22:3.2|
Show InChI InChI=1S/C17H21NO4/c1-18-12-8-9-13(18)15(17(20)21-2)14(10-12)22-16(19)11-6-4-3-5-7-11/h3-7,12-15H,8-10H2,1-2H3/t12-,13+,14-,15+/m0/s1
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 413n/an/an/an/an/an/an/an/a



Georgetown University Medical Center

Curated by ChEMBL


Assay Description
Inhibition of [3H]DA binding to dopamine transporter of rat brain synaptosomes

Bioorg Med Chem Lett 10: 1681-6 (2000)


BindingDB Entry DOI: 10.7270/Q2MG7Q0C
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Sodium-dependent dopamine transporter


(Rattus norvegicus (rat))		BDBM50090498
PNG
(4-(4-Chloro-phenyl)-1-methyl-piperidine-3-carboxyl...)
Show SMILES CN1CCC(C(C1)C(=O)OCCC(c1ccccc1)c1ccccc1)c1ccc(Cl)cc1
Show InChI InChI=1S/C28H30ClNO2/c1-30-18-16-26(23-12-14-24(29)15-13-23)27(20-30)28(31)32-19-17-25(21-8-4-2-5-9-21)22-10-6-3-7-11-22/h2-15,25-27H,16-20H2,1H3
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 420n/an/an/an/an/an/an/an/a



Georgetown University Medical Center

Curated by ChEMBL


Assay Description
Inhibition of [3H]- Mazindol binding to dopamine transporter of rat striatal membrane.

Bioorg Med Chem Lett 10: 1681-6 (2000)


BindingDB Entry DOI: 10.7270/Q2MG7Q0C
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Rattus norvegicus (rat))		BDBM50090494
PNG
((R)-4-(4-Chloro-phenyl)-1-aza-bicyclo[3.2.1]octan-...)
Show SMILES CO\N=C1\CN2CC1[C@@H](CC2)c1ccc(Cl)cc1
Show InChI InChI=1S/C14H17ClN2O/c1-18-16-14-9-17-7-6-12(13(14)8-17)10-2-4-11(15)5-3-10/h2-5,12-13H,6-9H2,1H3/b16-14-/t12-,13?/m0/s1
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 434n/an/an/an/an/an/an/an/a



Georgetown University Medical Center

Curated by ChEMBL


Assay Description
Inhibition of [3H]- Mazindol binding to dopamine transporter of rat striatal membrane.

Bioorg Med Chem Lett 10: 1681-6 (2000)


BindingDB Entry DOI: 10.7270/Q2MG7Q0C
More data for this
Ligand-Target Pair
Transporter


(Rattus norvegicus)		BDBM50090495
PNG
((R)-4-(4-Chloro-phenyl)-1-aza-bicyclo[3.2.1]octan-...)
Show SMILES Clc1ccc(cc1)[C@@H]1CCN2CC1\C(C2)=N\OCCCc1ccccc1 |TLB:15:13:11:7.8.9,THB:4:7:11:13.14|
Show InChI InChI=1S/C22H25ClN2O/c23-19-10-8-18(9-11-19)20-12-13-25-15-21(20)22(16-25)24-26-14-4-7-17-5-2-1-3-6-17/h1-3,5-6,8-11,20-21H,4,7,12-16H2/b24-22+/t20-,21?/m0/s1
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 483n/an/an/an/an/an/an/an/a



Georgetown University Medical Center

Curated by ChEMBL


Assay Description
Inhibition of [3H]NE binding to norepinephrine transporter of rat brain synaptosomes

Bioorg Med Chem Lett 10: 1681-6 (2000)


BindingDB Entry DOI: 10.7270/Q2MG7Q0C
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Rattus norvegicus (rat))		BDBM50090497
PNG
((S)-4-(4-Chloro-phenyl)-1-aza-bicyclo[3.2.1]octan-...)
Show SMILES CO\N=C1/CN2CC1[C@H](CC2)c1ccc(Cl)cc1
Show InChI InChI=1S/C14H17ClN2O/c1-18-16-14-9-17-7-6-12(13(14)8-17)10-2-4-11(15)5-3-10/h2-5,12-13H,6-9H2,1H3/b16-14+/t12-,13?/m1/s1
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 503n/an/an/an/an/an/an/an/a



Georgetown University Medical Center

Curated by ChEMBL


Assay Description
Inhibition of [3H]-5-HT binding to serotonin transporter of rat brain synaptosomes

Bioorg Med Chem Lett 10: 1681-6 (2000)


BindingDB Entry DOI: 10.7270/Q2MG7Q0C
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Rattus norvegicus (rat))		BDBM50090497
PNG
((S)-4-(4-Chloro-phenyl)-1-aza-bicyclo[3.2.1]octan-...)
Show SMILES CO\N=C1/CN2CC1[C@H](CC2)c1ccc(Cl)cc1
Show InChI InChI=1S/C14H17ClN2O/c1-18-16-14-9-17-7-6-12(13(14)8-17)10-2-4-11(15)5-3-10/h2-5,12-13H,6-9H2,1H3/b16-14+/t12-,13?/m1/s1
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 503n/an/an/an/an/an/an/an/a



Georgetown University Medical Center

Curated by ChEMBL


Assay Description
Inhibition of [3H]-5-HT binding to serotonin transporter of rat brain synaptosomes

Bioorg Med Chem Lett 10: 1681-6 (2000)


BindingDB Entry DOI: 10.7270/Q2MG7Q0C
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Rattus norvegicus (rat))		BDBM50090496
PNG
((R)-4-(4-Chloro-phenyl)-1-aza-bicyclo[3.2.1]octan-...)
Show SMILES CC(C)(C)O\N=C1/CN2CC1[C@@H](CC2)c1ccc(Cl)cc1 |TLB:14:11:9:6.7,THB:5:6:9:11.12.13|
Show InChI InChI=1S/C17H23ClN2O/c1-17(2,3)21-19-16-11-20-9-8-14(15(16)10-20)12-4-6-13(18)7-5-12/h4-7,14-15H,8-11H2,1-3H3/b19-16+/t14-,15?/m0/s1
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 641n/an/an/an/an/an/an/an/a



Georgetown University Medical Center

Curated by ChEMBL


Assay Description
Inhibition of [3H]- Mazindol binding to dopamine transporter of rat striatal membrane.

Bioorg Med Chem Lett 10: 1681-6 (2000)


BindingDB Entry DOI: 10.7270/Q2MG7Q0C
More data for this
Ligand-Target Pair
Transporter


(Rattus norvegicus)		BDBM50090490
PNG
((R)-4-(4-Chloro-phenyl)-1-aza-bicyclo[3.2.1]octan-...)
Show SMILES CO\N=C1/CN2CC1[C@@H](CC2)c1ccc(Cl)cc1 |TLB:11:8:6:3.4|
Show InChI InChI=1S/C14H17ClN2O/c1-18-16-14-9-17-7-6-12(13(14)8-17)10-2-4-11(15)5-3-10/h2-5,12-13H,6-9H2,1H3/b16-14+/t12-,13?/m0/s1
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 652n/an/an/an/an/an/an/an/a



Georgetown University Medical Center

Curated by ChEMBL


Assay Description
Inhibition of [3H]NE binding to norepinephrine transporter of rat brain synaptosomes

Bioorg Med Chem Lett 10: 1681-6 (2000)


BindingDB Entry DOI: 10.7270/Q2MG7Q0C
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Rattus norvegicus (rat))		BDBM50090496
PNG
((R)-4-(4-Chloro-phenyl)-1-aza-bicyclo[3.2.1]octan-...)
Show SMILES CC(C)(C)O\N=C1/CN2CC1[C@@H](CC2)c1ccc(Cl)cc1 |TLB:14:11:9:6.7,THB:5:6:9:11.12.13|
Show InChI InChI=1S/C17H23ClN2O/c1-17(2,3)21-19-16-11-20-9-8-14(15(16)10-20)12-4-6-13(18)7-5-12/h4-7,14-15H,8-11H2,1-3H3/b19-16+/t14-,15?/m0/s1
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 725n/an/an/an/an/an/an/an/a



Georgetown University Medical Center

Curated by ChEMBL


Assay Description
Inhibition of [3H]DA binding to dopamine transporter of rat brain synaptosomes

Bioorg Med Chem Lett 10: 1681-6 (2000)


BindingDB Entry DOI: 10.7270/Q2MG7Q0C
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Rattus norvegicus (rat))		BDBM50090492
PNG
((S)-4-(4-Chloro-phenyl)-1-aza-bicyclo[3.2.1]octan-...)
Show SMILES CO\N=C1\CN2CC1[C@H](CC2)c1ccc(Cl)cc1 |THB:11:8:6:3.4|
Show InChI InChI=1S/C14H17ClN2O/c1-18-16-14-9-17-7-6-12(13(14)8-17)10-2-4-11(15)5-3-10/h2-5,12-13H,6-9H2,1H3/b16-14-/t12-,13?/m1/s1
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 796n/an/an/an/an/an/an/an/a



Georgetown University Medical Center

Curated by ChEMBL


Assay Description
Inhibition of [3H]- Mazindol binding to dopamine transporter of rat striatal membrane.

Bioorg Med Chem Lett 10: 1681-6 (2000)


BindingDB Entry DOI: 10.7270/Q2MG7Q0C
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Rattus norvegicus (rat))		BDBM50090492
PNG
((S)-4-(4-Chloro-phenyl)-1-aza-bicyclo[3.2.1]octan-...)
Show SMILES CO\N=C1\CN2CC1[C@H](CC2)c1ccc(Cl)cc1 |THB:11:8:6:3.4|
Show InChI InChI=1S/C14H17ClN2O/c1-18-16-14-9-17-7-6-12(13(14)8-17)10-2-4-11(15)5-3-10/h2-5,12-13H,6-9H2,1H3/b16-14-/t12-,13?/m1/s1
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 856n/an/an/an/an/an/an/an/a



Georgetown University Medical Center

Curated by ChEMBL


Assay Description
Inhibition of [3H]-5-HT binding to serotonin transporter of rat brain synaptosomes

Bioorg Med Chem Lett 10: 1681-6 (2000)


BindingDB Entry DOI: 10.7270/Q2MG7Q0C
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Rattus norvegicus (rat))		BDBM50090491
PNG
((R)-4-(4-Chloro-phenyl)-1-aza-bicyclo[3.2.1]octan-...)
Show SMILES Clc1ccc(cc1)[C@@H]1CCN2CC1\C(C2)=N\OCc1ccccc1 |TLB:15:13:11:7.8.9,THB:4:7:11:13.14|
Show InChI InChI=1S/C20H21ClN2O/c21-17-8-6-16(7-9-17)18-10-11-23-12-19(18)20(13-23)22-24-14-15-4-2-1-3-5-15/h1-9,18-19H,10-14H2/b22-20+/t18-,19?/m0/s1
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 1.00E+3n/an/an/an/an/an/an/an/a



Georgetown University Medical Center

Curated by ChEMBL


Assay Description
Inhibition of [3H]- Mazindol binding to dopamine transporter of rat striatal membrane.

Bioorg Med Chem Lett 10: 1681-6 (2000)


BindingDB Entry DOI: 10.7270/Q2MG7Q0C
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Rattus norvegicus (rat))		BDBM50090498
PNG
(4-(4-Chloro-phenyl)-1-methyl-piperidine-3-carboxyl...)
Show SMILES CN1CCC(C(C1)C(=O)OCCC(c1ccccc1)c1ccccc1)c1ccc(Cl)cc1
Show InChI InChI=1S/C28H30ClNO2/c1-30-18-16-26(23-12-14-24(29)15-13-23)27(20-30)28(31)32-19-17-25(21-8-4-2-5-9-21)22-10-6-3-7-11-22/h2-15,25-27H,16-20H2,1H3
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 1.16E+3n/an/an/an/an/an/an/an/a



Georgetown University Medical Center

Curated by ChEMBL


Assay Description
Inhibition of [3H]DA binding to dopamine transporter of rat brain synaptosomes

Bioorg Med Chem Lett 10: 1681-6 (2000)


BindingDB Entry DOI: 10.7270/Q2MG7Q0C
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Rattus norvegicus (rat))		BDBM50090500
PNG
(4-(4-Chloro-phenyl)-1-methyl-piperidine-3-carboxyl...)
Show SMILES CN1CCC(C(C1)C(=O)OCCCc1ccccc1)c1ccc(Cl)cc1
Show InChI InChI=1S/C22H26ClNO2/c1-24-14-13-20(18-9-11-19(23)12-10-18)21(16-24)22(25)26-15-5-8-17-6-3-2-4-7-17/h2-4,6-7,9-12,20-21H,5,8,13-16H2,1H3
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 1.42E+3n/an/an/an/an/an/an/an/a



Georgetown University Medical Center

Curated by ChEMBL


Assay Description
Inhibition of [3H]DA binding to dopamine transporter of rat brain synaptosomes

Bioorg Med Chem Lett 10: 1681-6 (2000)


BindingDB Entry DOI: 10.7270/Q2MG7Q0C
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Rattus norvegicus (rat))		BDBM50090497
PNG
((S)-4-(4-Chloro-phenyl)-1-aza-bicyclo[3.2.1]octan-...)
Show SMILES CO\N=C1/CN2CC1[C@H](CC2)c1ccc(Cl)cc1
Show InChI InChI=1S/C14H17ClN2O/c1-18-16-14-9-17-7-6-12(13(14)8-17)10-2-4-11(15)5-3-10/h2-5,12-13H,6-9H2,1H3/b16-14+/t12-,13?/m1/s1
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 1.43E+3n/an/an/an/an/an/an/an/a



Georgetown University Medical Center

Curated by ChEMBL


Assay Description
Inhibition of [3H]- Mazindol binding to dopamine transporter of rat striatal membrane.

Bioorg Med Chem Lett 10: 1681-6 (2000)


BindingDB Entry DOI: 10.7270/Q2MG7Q0C
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Rattus norvegicus (rat))		BDBM50090500
PNG
(4-(4-Chloro-phenyl)-1-methyl-piperidine-3-carboxyl...)
Show SMILES CN1CCC(C(C1)C(=O)OCCCc1ccccc1)c1ccc(Cl)cc1
Show InChI InChI=1S/C22H26ClNO2/c1-24-14-13-20(18-9-11-19(23)12-10-18)21(16-24)22(25)26-15-5-8-17-6-3-2-4-7-17/h2-4,6-7,9-12,20-21H,5,8,13-16H2,1H3
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 1.49E+3n/an/an/an/an/an/an/an/a



Georgetown University Medical Center

Curated by ChEMBL


Assay Description
Inhibition of [3H]NE binding to norepinephrine transporter of rat brain synaptosomes

Bioorg Med Chem Lett 10: 1681-6 (2000)


BindingDB Entry DOI: 10.7270/Q2MG7Q0C
More data for this
Ligand-Target Pair
Transporter


(Rattus norvegicus)		BDBM50090491
PNG
((R)-4-(4-Chloro-phenyl)-1-aza-bicyclo[3.2.1]octan-...)
Show SMILES Clc1ccc(cc1)[C@@H]1CCN2CC1\C(C2)=N\OCc1ccccc1 |TLB:15:13:11:7.8.9,THB:4:7:11:13.14|
Show InChI InChI=1S/C20H21ClN2O/c21-17-8-6-16(7-9-17)18-10-11-23-12-19(18)20(13-23)22-24-14-15-4-2-1-3-5-15/h1-9,18-19H,10-14H2/b22-20+/t18-,19?/m0/s1
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 1.55E+3n/an/an/an/an/an/an/an/a



Georgetown University Medical Center

Curated by ChEMBL


Assay Description
Inhibition of [3H]NE binding to norepinephrine transporter of rat brain synaptosomes

Bioorg Med Chem Lett 10: 1681-6 (2000)


BindingDB Entry DOI: 10.7270/Q2MG7Q0C
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Rattus norvegicus (rat))		BDBM50090490
PNG
((R)-4-(4-Chloro-phenyl)-1-aza-bicyclo[3.2.1]octan-...)
Show SMILES CO\N=C1/CN2CC1[C@@H](CC2)c1ccc(Cl)cc1 |TLB:11:8:6:3.4|
Show InChI InChI=1S/C14H17ClN2O/c1-18-16-14-9-17-7-6-12(13(14)8-17)10-2-4-11(15)5-3-10/h2-5,12-13H,6-9H2,1H3/b16-14+/t12-,13?/m0/s1
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 1.79E+3n/an/an/an/an/an/an/an/a



Georgetown University Medical Center

Curated by ChEMBL


Assay Description
Inhibition of [3H]-5-HT binding to serotonin transporter of rat brain synaptosomes

Bioorg Med Chem Lett 10: 1681-6 (2000)


BindingDB Entry DOI: 10.7270/Q2MG7Q0C
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Rattus norvegicus (rat))		BDBM50090490
PNG
((R)-4-(4-Chloro-phenyl)-1-aza-bicyclo[3.2.1]octan-...)
Show SMILES CO\N=C1/CN2CC1[C@@H](CC2)c1ccc(Cl)cc1 |TLB:11:8:6:3.4|
Show InChI InChI=1S/C14H17ClN2O/c1-18-16-14-9-17-7-6-12(13(14)8-17)10-2-4-11(15)5-3-10/h2-5,12-13H,6-9H2,1H3/b16-14+/t12-,13?/m0/s1
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 1.79E+3n/an/an/an/an/an/an/an/a



Georgetown University Medical Center

Curated by ChEMBL


Assay Description
Inhibition of [3H]-5-HT binding to serotonin transporter of rat brain synaptosomes

Bioorg Med Chem Lett 10: 1681-6 (2000)


BindingDB Entry DOI: 10.7270/Q2MG7Q0C
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Rattus norvegicus (rat))		BDBM50090499
PNG
(4-(4-Chloro-phenyl)-1-methyl-piperidine-3-carboxyl...)
Show SMILES CN1CCC(C(C1)C(=O)OCCCCCc1ccccc1)c1ccc(Cl)cc1
Show InChI InChI=1S/C24H30ClNO2/c1-26-16-15-22(20-11-13-21(25)14-12-20)23(18-26)24(27)28-17-7-3-6-10-19-8-4-2-5-9-19/h2,4-5,8-9,11-14,22-23H,3,6-7,10,15-18H2,1H3
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 1.79E+3n/an/an/an/an/an/an/an/a



Georgetown University Medical Center

Curated by ChEMBL


Assay Description
Inhibition of [3H]-5-HT binding to serotonin transporter of rat brain synaptosomes

Bioorg Med Chem Lett 10: 1681-6 (2000)


BindingDB Entry DOI: 10.7270/Q2MG7Q0C
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Rattus norvegicus (rat))		BDBM50090491
PNG
((R)-4-(4-Chloro-phenyl)-1-aza-bicyclo[3.2.1]octan-...)
Show SMILES Clc1ccc(cc1)[C@@H]1CCN2CC1\C(C2)=N\OCc1ccccc1 |TLB:15:13:11:7.8.9,THB:4:7:11:13.14|
Show InChI InChI=1S/C20H21ClN2O/c21-17-8-6-16(7-9-17)18-10-11-23-12-19(18)20(13-23)22-24-14-15-4-2-1-3-5-15/h1-9,18-19H,10-14H2/b22-20+/t18-,19?/m0/s1
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 1.86E+3n/an/an/an/an/an/an/an/a



Georgetown University Medical Center

Curated by ChEMBL


Assay Description
Inhibition of [3H]- Mazindol binding to dopamine transporter of rat striatal membrane.

Bioorg Med Chem Lett 10: 1681-6 (2000)


BindingDB Entry DOI: 10.7270/Q2MG7Q0C
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Rattus norvegicus (rat))		BDBM50090494
PNG
((R)-4-(4-Chloro-phenyl)-1-aza-bicyclo[3.2.1]octan-...)
Show SMILES CO\N=C1\CN2CC1[C@@H](CC2)c1ccc(Cl)cc1
Show InChI InChI=1S/C14H17ClN2O/c1-18-16-14-9-17-7-6-12(13(14)8-17)10-2-4-11(15)5-3-10/h2-5,12-13H,6-9H2,1H3/b16-14-/t12-,13?/m0/s1
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>2.00E+3n/an/an/an/an/an/an/an/a



Georgetown University Medical Center

Curated by ChEMBL


Assay Description
Inhibition of [3H]-5-HT binding to serotonin transporter of rat brain synaptosomes

Bioorg Med Chem Lett 10: 1681-6 (2000)


BindingDB Entry DOI: 10.7270/Q2MG7Q0C
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Rattus norvegicus (rat))		BDBM50090500
PNG
(4-(4-Chloro-phenyl)-1-methyl-piperidine-3-carboxyl...)
Show SMILES CN1CCC(C(C1)C(=O)OCCCc1ccccc1)c1ccc(Cl)cc1
Show InChI InChI=1S/C22H26ClNO2/c1-24-14-13-20(18-9-11-19(23)12-10-18)21(16-24)22(25)26-15-5-8-17-6-3-2-4-7-17/h2-4,6-7,9-12,20-21H,5,8,13-16H2,1H3
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 2.16E+3n/an/an/an/an/an/an/an/a



Georgetown University Medical Center

Curated by ChEMBL


Assay Description
Inhibition of [3H]-5-HT binding to serotonin transporter of rat brain synaptosomes

Bioorg Med Chem Lett 10: 1681-6 (2000)


BindingDB Entry DOI: 10.7270/Q2MG7Q0C
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Rattus norvegicus (rat))		BDBM50090498
PNG
(4-(4-Chloro-phenyl)-1-methyl-piperidine-3-carboxyl...)
Show SMILES CN1CCC(C(C1)C(=O)OCCC(c1ccccc1)c1ccccc1)c1ccc(Cl)cc1
Show InChI InChI=1S/C28H30ClNO2/c1-30-18-16-26(23-12-14-24(29)15-13-23)27(20-30)28(31)32-19-17-25(21-8-4-2-5-9-21)22-10-6-3-7-11-22/h2-15,25-27H,16-20H2,1H3
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 2.59E+3n/an/an/an/an/an/an/an/a



Georgetown University Medical Center

Curated by ChEMBL


Assay Description
Inhibition of [3H]-5-HT binding to serotonin transporter of rat brain synaptosomes

Bioorg Med Chem Lett 10: 1681-6 (2000)


BindingDB Entry DOI: 10.7270/Q2MG7Q0C
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Rattus norvegicus (rat))		BDBM50090490
PNG
((R)-4-(4-Chloro-phenyl)-1-aza-bicyclo[3.2.1]octan-...)
Show SMILES CO\N=C1/CN2CC1[C@@H](CC2)c1ccc(Cl)cc1 |TLB:11:8:6:3.4|
Show InChI InChI=1S/C14H17ClN2O/c1-18-16-14-9-17-7-6-12(13(14)8-17)10-2-4-11(15)5-3-10/h2-5,12-13H,6-9H2,1H3/b16-14+/t12-,13?/m0/s1
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 2.66E+3n/an/an/an/an/an/an/an/a



Georgetown University Medical Center

Curated by ChEMBL


Assay Description
Inhibition of [3H]DA binding to dopamine transporter of rat brain synaptosomes

Bioorg Med Chem Lett 10: 1681-6 (2000)


BindingDB Entry DOI: 10.7270/Q2MG7Q0C
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Rattus norvegicus (rat))		BDBM50090490
PNG
((R)-4-(4-Chloro-phenyl)-1-aza-bicyclo[3.2.1]octan-...)
Show SMILES CO\N=C1/CN2CC1[C@@H](CC2)c1ccc(Cl)cc1 |TLB:11:8:6:3.4|
Show InChI InChI=1S/C14H17ClN2O/c1-18-16-14-9-17-7-6-12(13(14)8-17)10-2-4-11(15)5-3-10/h2-5,12-13H,6-9H2,1H3/b16-14+/t12-,13?/m0/s1
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 2.79E+3n/an/an/an/an/an/an/an/a



Georgetown University Medical Center

Curated by ChEMBL


Assay Description
Inhibition of [3H]- Mazindol binding to dopamine transporter of rat striatal membrane.

Bioorg Med Chem Lett 10: 1681-6 (2000)


BindingDB Entry DOI: 10.7270/Q2MG7Q0C
More data for this
Ligand-Target Pair
Transporter


(Rattus norvegicus)		BDBM50090498
PNG
(4-(4-Chloro-phenyl)-1-methyl-piperidine-3-carboxyl...)
Show SMILES CN1CCC(C(C1)C(=O)OCCC(c1ccccc1)c1ccccc1)c1ccc(Cl)cc1
Show InChI InChI=1S/C28H30ClNO2/c1-30-18-16-26(23-12-14-24(29)15-13-23)27(20-30)28(31)32-19-17-25(21-8-4-2-5-9-21)22-10-6-3-7-11-22/h2-15,25-27H,16-20H2,1H3
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 3.14E+3n/an/an/an/an/an/an/an/a



Georgetown University Medical Center

Curated by ChEMBL


Assay Description
Inhibition of [3H]NE binding to norepinephrine transporter of rat brain synaptosomes

Bioorg Med Chem Lett 10: 1681-6 (2000)


BindingDB Entry DOI: 10.7270/Q2MG7Q0C
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Rattus norvegicus (rat))		BDBM50090497
PNG
((S)-4-(4-Chloro-phenyl)-1-aza-bicyclo[3.2.1]octan-...)
Show SMILES CO\N=C1/CN2CC1[C@H](CC2)c1ccc(Cl)cc1
Show InChI InChI=1S/C14H17ClN2O/c1-18-16-14-9-17-7-6-12(13(14)8-17)10-2-4-11(15)5-3-10/h2-5,12-13H,6-9H2,1H3/b16-14+/t12-,13?/m1/s1
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 3.64E+3n/an/an/an/an/an/an/an/a



Georgetown University Medical Center

Curated by ChEMBL


Assay Description
Inhibition of [3H]DA binding to dopamine transporter of rat brain synaptosomes

Bioorg Med Chem Lett 10: 1681-6 (2000)


BindingDB Entry DOI: 10.7270/Q2MG7Q0C
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Rattus norvegicus (rat))		BDBM50090497
PNG
((S)-4-(4-Chloro-phenyl)-1-aza-bicyclo[3.2.1]octan-...)
Show SMILES CO\N=C1/CN2CC1[C@H](CC2)c1ccc(Cl)cc1
Show InChI InChI=1S/C14H17ClN2O/c1-18-16-14-9-17-7-6-12(13(14)8-17)10-2-4-11(15)5-3-10/h2-5,12-13H,6-9H2,1H3/b16-14+/t12-,13?/m1/s1
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 3.64E+3n/an/an/an/an/an/an/an/a



Georgetown University Medical Center

Curated by ChEMBL


Assay Description
Inhibition of [3H]DA binding to dopamine transporter of rat brain synaptosomes

Bioorg Med Chem Lett 10: 1681-6 (2000)


BindingDB Entry DOI: 10.7270/Q2MG7Q0C
More data for this
Ligand-Target Pair
Transporter


(Rattus norvegicus)		BDBM50090490
PNG
((R)-4-(4-Chloro-phenyl)-1-aza-bicyclo[3.2.1]octan-...)
Show SMILES CO\N=C1/CN2CC1[C@@H](CC2)c1ccc(Cl)cc1 |TLB:11:8:6:3.4|
Show InChI InChI=1S/C14H17ClN2O/c1-18-16-14-9-17-7-6-12(13(14)8-17)10-2-4-11(15)5-3-10/h2-5,12-13H,6-9H2,1H3/b16-14+/t12-,13?/m0/s1
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>4.00E+3n/an/an/an/an/an/an/an/a



Georgetown University Medical Center

Curated by ChEMBL


Assay Description
Inhibition of [3H]NE binding to norepinephrine transporter of rat brain synaptosomes

Bioorg Med Chem Lett 10: 1681-6 (2000)


BindingDB Entry DOI: 10.7270/Q2MG7Q0C
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Rattus norvegicus (rat))		BDBM50090497
PNG
((S)-4-(4-Chloro-phenyl)-1-aza-bicyclo[3.2.1]octan-...)
Show SMILES CO\N=C1/CN2CC1[C@H](CC2)c1ccc(Cl)cc1
Show InChI InChI=1S/C14H17ClN2O/c1-18-16-14-9-17-7-6-12(13(14)8-17)10-2-4-11(15)5-3-10/h2-5,12-13H,6-9H2,1H3/b16-14+/t12-,13?/m1/s1
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>5.00E+3n/an/an/an/an/an/an/an/a



Georgetown University Medical Center

Curated by ChEMBL


Assay Description
Inhibition of [3H]DA binding to dopamine transporter of rat brain synaptosomes

Bioorg Med Chem Lett 10: 1681-6 (2000)


BindingDB Entry DOI: 10.7270/Q2MG7Q0C
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Rattus norvegicus (rat))		BDBM50090493
PNG
(4-(4-Chloro-phenyl)-1-methyl-piperidine-3-carboxyl...)
Show SMILES COC(=O)C1CN(C)CCC1c1ccc(Cl)cc1
Show InChI InChI=1S/C14H18ClNO2/c1-16-8-7-12(13(9-16)14(17)18-2)10-3-5-11(15)6-4-10/h3-6,12-13H,7-9H2,1-2H3
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 5.88E+3n/an/an/an/an/an/an/an/a



Georgetown University Medical Center

Curated by ChEMBL


Assay Description
Inhibition of [3H]-5-HT binding to serotonin transporter of rat brain synaptosomes

Bioorg Med Chem Lett 10: 1681-6 (2000)


BindingDB Entry DOI: 10.7270/Q2MG7Q0C
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Rattus norvegicus (rat))		BDBM50090490
PNG
((R)-4-(4-Chloro-phenyl)-1-aza-bicyclo[3.2.1]octan-...)
Show SMILES CO\N=C1/CN2CC1[C@@H](CC2)c1ccc(Cl)cc1 |TLB:11:8:6:3.4|
Show InChI InChI=1S/C14H17ClN2O/c1-18-16-14-9-17-7-6-12(13(14)8-17)10-2-4-11(15)5-3-10/h2-5,12-13H,6-9H2,1H3/b16-14+/t12-,13?/m0/s1
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>3.60E+4n/an/an/an/an/an/an/an/a



Georgetown University Medical Center

Curated by ChEMBL


Assay Description
Inhibition of [3H]- Mazindol binding to dopamine transporter of rat striatal membrane.

Bioorg Med Chem Lett 10: 1681-6 (2000)


BindingDB Entry DOI: 10.7270/Q2MG7Q0C
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Rattus norvegicus (rat))		BDBM50090490
PNG
((R)-4-(4-Chloro-phenyl)-1-aza-bicyclo[3.2.1]octan-...)
Show SMILES CO\N=C1/CN2CC1[C@@H](CC2)c1ccc(Cl)cc1 |TLB:11:8:6:3.4|
Show InChI InChI=1S/C14H17ClN2O/c1-18-16-14-9-17-7-6-12(13(14)8-17)10-2-4-11(15)5-3-10/h2-5,12-13H,6-9H2,1H3/b16-14+/t12-,13?/m0/s1
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>4.50E+4n/an/an/an/an/an/an/an/a



Georgetown University Medical Center

Curated by ChEMBL


Assay Description
Inhibition of [3H]-5-HT binding to serotonin transporter of rat brain synaptosomes

Bioorg Med Chem Lett 10: 1681-6 (2000)


BindingDB Entry DOI: 10.7270/Q2MG7Q0C
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%