Found 34 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D
(Homo sapiens (Human)) | BDBM50218255
(CHEMBL290100)Show SMILES COc1ccc(C(=O)Nc2c(Cl)cncc2Cl)c2cc(oc12)C(C)=O Show InChI InChI=1S/C17H12Cl2N2O4/c1-8(22)14-5-10-9(3-4-13(24-2)16(10)25-14)17(23)21-15-11(18)6-20-7-12(15)19/h3-7H,1-2H3,(H,20,21,23) | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
| PubMed
| n/a | n/a | 1.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Celltech-Chiroscience Ltd
Curated by ChEMBL
| Assay Description
Inhibition of Phosphodiesterase 4 from human U937 cells |
Bioorg Med Chem Lett 10: 2137-40 (2000)
BindingDB Entry DOI: 10.7270/Q2NP26MQ |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D
(Homo sapiens (Human)) | BDBM50218257
(CHEMBL69874)Show SMILES COc1ccc(C(=O)Nc2c(Cl)cncc2Cl)c2cc(oc12)C(=O)c1ccncc1 Show InChI InChI=1S/C21H13Cl2N3O4/c1-29-16-3-2-12(21(28)26-18-14(22)9-25-10-15(18)23)13-8-17(30-20(13)16)19(27)11-4-6-24-7-5-11/h2-10H,1H3,(H,25,26,28) | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 2.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Celltech-Chiroscience Ltd
Curated by ChEMBL
| Assay Description
Inhibition of Phosphodiesterase 4 from human U937 cells |
Bioorg Med Chem Lett 10: 2137-40 (2000)
BindingDB Entry DOI: 10.7270/Q2NP26MQ |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D
(Homo sapiens (Human)) | BDBM50218258
(CHEMBL70146)Show InChI InChI=1S/C17H13ClN2O4/c1-9(21)15-7-11-10(3-4-14(23-2)16(11)24-15)17(22)20-13-5-6-19-8-12(13)18/h3-8H,1-2H3,(H,19,20,22) | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 6.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Celltech-Chiroscience Ltd
Curated by ChEMBL
| Assay Description
Inhibition of Phosphodiesterase 4 from human U937 cells |
Bioorg Med Chem Lett 10: 2137-40 (2000)
BindingDB Entry DOI: 10.7270/Q2NP26MQ |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4C
(Rattus norvegicus) | BDBM50218245
(CHEMBL65799)Show InChI InChI=1S/C16H9Cl2N3O3/c1-23-13-3-2-9(10-4-8(5-19)24-15(10)13)16(22)21-14-11(17)6-20-7-12(14)18/h2-4,6-7H,1H3,(H,20,21,22) | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 6.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Celltech-Chiroscience Ltd
Curated by ChEMBL
| Assay Description
Inhibition of rolipram binding to rat brain tissue at 20 uM |
Bioorg Med Chem Lett 10: 2137-40 (2000)
BindingDB Entry DOI: 10.7270/Q2NP26MQ |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D
(Homo sapiens (Human)) | BDBM50218245
(CHEMBL65799)Show InChI InChI=1S/C16H9Cl2N3O3/c1-23-13-3-2-9(10-4-8(5-19)24-15(10)13)16(22)21-14-11(17)6-20-7-12(14)18/h2-4,6-7H,1H3,(H,20,21,22) | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 6.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Celltech-Chiroscience Ltd
Curated by ChEMBL
| Assay Description
Inhibition of Phosphodiesterase 4 from human U937 cells |
Bioorg Med Chem Lett 10: 2137-40 (2000)
BindingDB Entry DOI: 10.7270/Q2NP26MQ |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4C
(Rattus norvegicus) | BDBM50218257
(CHEMBL69874)Show SMILES COc1ccc(C(=O)Nc2c(Cl)cncc2Cl)c2cc(oc12)C(=O)c1ccncc1 Show InChI InChI=1S/C21H13Cl2N3O4/c1-29-16-3-2-12(21(28)26-18-14(22)9-25-10-15(18)23)13-8-17(30-20(13)16)19(27)11-4-6-24-7-5-11/h2-10H,1H3,(H,25,26,28) | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 8.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Celltech-Chiroscience Ltd
Curated by ChEMBL
| Assay Description
Inhibition of rolipram binding to rat brain tissue at 20 uM |
Bioorg Med Chem Lett 10: 2137-40 (2000)
BindingDB Entry DOI: 10.7270/Q2NP26MQ |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D
(Homo sapiens (Human)) | BDBM50218246
(CHEMBL68323)Show SMILES COc1ccc(C(=O)Nc2c(Cl)cncc2Cl)c2cc(oc12)C(C)O Show InChI InChI=1S/C17H14Cl2N2O4/c1-8(22)14-5-10-9(3-4-13(24-2)16(10)25-14)17(23)21-15-11(18)6-20-7-12(15)19/h3-8,22H,1-2H3,(H,20,21,23) | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| PubMed
| n/a | n/a | 8.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Celltech-Chiroscience Ltd
Curated by ChEMBL
| Assay Description
Inhibition of Phosphodiesterase 4 from human U937 cells |
Bioorg Med Chem Lett 10: 2137-40 (2000)
BindingDB Entry DOI: 10.7270/Q2NP26MQ |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D
(Homo sapiens (Human)) | BDBM50218249
(CHEMBL304051)Show SMILES COc1ccc(C(=O)Nc2c(Cl)cncc2Cl)c2cc(CC(C)(C)C)oc12 Show InChI InChI=1S/C20H20Cl2N2O3/c1-20(2,3)8-11-7-13-12(5-6-16(26-4)18(13)27-11)19(25)24-17-14(21)9-23-10-15(17)22/h5-7,9-10H,8H2,1-4H3,(H,23,24,25) | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 17 | n/a | n/a | n/a | n/a | n/a | n/a |
Celltech-Chiroscience Ltd
Curated by ChEMBL
| Assay Description
Inhibition of Phosphodiesterase 4 from human U937 cells |
Bioorg Med Chem Lett 10: 2137-40 (2000)
BindingDB Entry DOI: 10.7270/Q2NP26MQ |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4C
(Rattus norvegicus) | BDBM50218246
(CHEMBL68323)Show SMILES COc1ccc(C(=O)Nc2c(Cl)cncc2Cl)c2cc(oc12)C(C)O Show InChI InChI=1S/C17H14Cl2N2O4/c1-8(22)14-5-10-9(3-4-13(24-2)16(10)25-14)17(23)21-15-11(18)6-20-7-12(15)19/h3-8,22H,1-2H3,(H,20,21,23) | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| PubMed
| n/a | n/a | 19 | n/a | n/a | n/a | n/a | n/a | n/a |
Celltech-Chiroscience Ltd
Curated by ChEMBL
| Assay Description
Inhibition of rolipram binding to rat brain tissue at 20 uM |
Bioorg Med Chem Lett 10: 2137-40 (2000)
BindingDB Entry DOI: 10.7270/Q2NP26MQ |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4C
(Rattus norvegicus) | BDBM14361
((R,S)-Rolipram | 4-(3-cyclopentyloxy-4-methoxy-phe...)Show InChI InChI=1S/C16H21NO3/c1-19-14-7-6-11(12-9-16(18)17-10-12)8-15(14)20-13-4-2-3-5-13/h6-8,12-13H,2-5,9-10H2,1H3,(H,17,18) | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
PC cid
PC sid
PDB
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
Celltech-Chiroscience Ltd
Curated by ChEMBL
| Assay Description
Inhibition of rolipram binding to rat brain tissue at 20 uM |
Bioorg Med Chem Lett 10: 2137-40 (2000)
BindingDB Entry DOI: 10.7270/Q2NP26MQ |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4C
(Rattus norvegicus) | BDBM50218259
(CHEMBL67898)Show InChI InChI=1S/C17H14Cl2N2O3/c1-3-9-6-11-10(4-5-14(23-2)16(11)24-9)17(22)21-15-12(18)7-20-8-13(15)19/h4-8H,3H2,1-2H3,(H,20,21,22) | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 23 | n/a | n/a | n/a | n/a | n/a | n/a |
Celltech-Chiroscience Ltd
Curated by ChEMBL
| Assay Description
Inhibition of rolipram binding to rat brain tissue at 20 uM |
Bioorg Med Chem Lett 10: 2137-40 (2000)
BindingDB Entry DOI: 10.7270/Q2NP26MQ |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D
(Homo sapiens (Human)) | BDBM50218259
(CHEMBL67898)Show InChI InChI=1S/C17H14Cl2N2O3/c1-3-9-6-11-10(4-5-14(23-2)16(11)24-9)17(22)21-15-12(18)7-20-8-13(15)19/h4-8H,3H2,1-2H3,(H,20,21,22) | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 27 | n/a | n/a | n/a | n/a | n/a | n/a |
Celltech-Chiroscience Ltd
Curated by ChEMBL
| Assay Description
Inhibition of Phosphodiesterase 4 from human U937 cells |
Bioorg Med Chem Lett 10: 2137-40 (2000)
BindingDB Entry DOI: 10.7270/Q2NP26MQ |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4C
(Rattus norvegicus) | BDBM50218258
(CHEMBL70146)Show InChI InChI=1S/C17H13ClN2O4/c1-9(21)15-7-11-10(3-4-14(23-2)16(11)24-15)17(22)20-13-5-6-19-8-12(13)18/h3-8H,1-2H3,(H,19,20,22) | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 32 | n/a | n/a | n/a | n/a | n/a | n/a |
Celltech-Chiroscience Ltd
Curated by ChEMBL
| Assay Description
Inhibition of rolipram binding in rat brain tissue |
Bioorg Med Chem Lett 10: 2137-40 (2000)
BindingDB Entry DOI: 10.7270/Q2NP26MQ |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4C
(Rattus norvegicus) | BDBM50218255
(CHEMBL290100)Show SMILES COc1ccc(C(=O)Nc2c(Cl)cncc2Cl)c2cc(oc12)C(C)=O Show InChI InChI=1S/C17H12Cl2N2O4/c1-8(22)14-5-10-9(3-4-13(24-2)16(10)25-14)17(23)21-15-11(18)6-20-7-12(15)19/h3-7H,1-2H3,(H,20,21,23) | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| PubMed
| n/a | n/a | 43 | n/a | n/a | n/a | n/a | n/a | n/a |
Celltech-Chiroscience Ltd
Curated by ChEMBL
| Assay Description
Inhibition of rolipram binding to rat brain tissue at 20 uM |
Bioorg Med Chem Lett 10: 2137-40 (2000)
BindingDB Entry DOI: 10.7270/Q2NP26MQ |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D
(Homo sapiens (Human)) | BDBM50218248
(CHEMBL69776)Show InChI InChI=1S/C18H14ClNO4/c1-10(21)16-9-12-11(7-8-15(23-2)17(12)24-16)18(22)20-14-6-4-3-5-13(14)19/h3-9H,1-2H3,(H,20,22) | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 54 | n/a | n/a | n/a | n/a | n/a | n/a |
Celltech-Chiroscience Ltd
Curated by ChEMBL
| Assay Description
Inhibition of Phosphodiesterase 4 from human U937 cells |
Bioorg Med Chem Lett 10: 2137-40 (2000)
BindingDB Entry DOI: 10.7270/Q2NP26MQ |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4C
(Rattus norvegicus) | BDBM50218244
(CHEMBL66233)Show InChI InChI=1S/C16H12ClN3O4/c1-8(21)13-5-10-9(3-4-12(23-2)14(10)24-13)16(22)20-15-11(17)6-18-7-19-15/h3-7H,1-2H3,(H,18,19,20,22) | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| PubMed
| n/a | n/a | 60 | n/a | n/a | n/a | n/a | n/a | n/a |
Celltech-Chiroscience Ltd
Curated by ChEMBL
| Assay Description
Inhibition of rolipram binding in rat brain tissue |
Bioorg Med Chem Lett 10: 2137-40 (2000)
BindingDB Entry DOI: 10.7270/Q2NP26MQ |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4C
(Rattus norvegicus) | BDBM50218249
(CHEMBL304051)Show SMILES COc1ccc(C(=O)Nc2c(Cl)cncc2Cl)c2cc(CC(C)(C)C)oc12 Show InChI InChI=1S/C20H20Cl2N2O3/c1-20(2,3)8-11-7-13-12(5-6-16(26-4)18(13)27-11)19(25)24-17-14(21)9-23-10-15(17)22/h5-7,9-10H,8H2,1-4H3,(H,23,24,25) | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 75 | n/a | n/a | n/a | n/a | n/a | n/a |
Celltech-Chiroscience Ltd
Curated by ChEMBL
| Assay Description
Inhibition of rolipram binding to rat brain tissue at 20 uM |
Bioorg Med Chem Lett 10: 2137-40 (2000)
BindingDB Entry DOI: 10.7270/Q2NP26MQ |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D
(Homo sapiens (Human)) | BDBM50218247
(CHEMBL66798)Show SMILES COc1ccc(C(=O)Nc2c(Cl)cc(cc2Cl)C#N)c2cc(oc12)C(C)=O Show InChI InChI=1S/C19H12Cl2N2O4/c1-9(24)16-7-12-11(3-4-15(26-2)18(12)27-16)19(25)23-17-13(20)5-10(8-22)6-14(17)21/h3-7H,1-2H3,(H,23,25) | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| PubMed
| n/a | n/a | 85 | n/a | n/a | n/a | n/a | n/a | n/a |
Celltech-Chiroscience Ltd
Curated by ChEMBL
| Assay Description
Inhibition of Phosphodiesterase 4 from human U937 cells |
Bioorg Med Chem Lett 10: 2137-40 (2000)
BindingDB Entry DOI: 10.7270/Q2NP26MQ |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D
(Homo sapiens (Human)) | BDBM50218256
(CHEMBL70145)Show InChI InChI=1S/C17H14N2O4/c1-10(20)15-9-13-12(3-4-14(22-2)16(13)23-15)17(21)19-11-5-7-18-8-6-11/h3-9H,1-2H3,(H,18,19,21) | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 120 | n/a | n/a | n/a | n/a | n/a | n/a |
Celltech-Chiroscience Ltd
Curated by ChEMBL
| Assay Description
Inhibition of Phosphodiesterase 4 from human U937 cells |
Bioorg Med Chem Lett 10: 2137-40 (2000)
BindingDB Entry DOI: 10.7270/Q2NP26MQ |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4C
(Rattus norvegicus) | BDBM50218250
(CHEMBL305176)Show SMILES COc1ccc(C(=O)N(C)c2c(Cl)cncc2Cl)c2cc(oc12)C(C)=O Show InChI InChI=1S/C18H14Cl2N2O4/c1-9(23)15-6-11-10(4-5-14(25-3)17(11)26-15)18(24)22(2)16-12(19)7-21-8-13(16)20/h4-8H,1-3H3 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 150 | n/a | n/a | n/a | n/a | n/a | n/a |
Celltech-Chiroscience Ltd
Curated by ChEMBL
| Assay Description
Inhibition of rolipram binding in rat brain tissue |
Bioorg Med Chem Lett 10: 2137-40 (2000)
BindingDB Entry DOI: 10.7270/Q2NP26MQ |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4C
(Rattus norvegicus) | BDBM50218254
(CHEMBL302799)Show SMILES COc1ccc(C(=O)Nc2c(Cl)cncc2Cl)c2c(C)c(oc12)C(C)=O Show InChI InChI=1S/C18H14Cl2N2O4/c1-8-14-10(18(24)22-15-11(19)6-21-7-12(15)20)4-5-13(25-3)17(14)26-16(8)9(2)23/h4-7H,1-3H3,(H,21,22,24) | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| PubMed
| n/a | n/a | 160 | n/a | n/a | n/a | n/a | n/a | n/a |
Celltech-Chiroscience Ltd
Curated by ChEMBL
| Assay Description
Inhibition of rolipram binding in rat brain tissue |
Bioorg Med Chem Lett 10: 2137-40 (2000)
BindingDB Entry DOI: 10.7270/Q2NP26MQ |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D
(Homo sapiens (Human)) | BDBM50218244
(CHEMBL66233)Show InChI InChI=1S/C16H12ClN3O4/c1-8(21)13-5-10-9(3-4-12(23-2)14(10)24-13)16(22)20-15-11(17)6-18-7-19-15/h3-7H,1-2H3,(H,18,19,20,22) | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| PubMed
| n/a | n/a | 164 | n/a | n/a | n/a | n/a | n/a | n/a |
Celltech-Chiroscience Ltd
Curated by ChEMBL
| Assay Description
Inhibition of Phosphodiesterase 4 from human U937 cells |
Bioorg Med Chem Lett 10: 2137-40 (2000)
BindingDB Entry DOI: 10.7270/Q2NP26MQ |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4C
(Rattus norvegicus) | BDBM50218253
(CHEMBL70090)Show InChI InChI=1S/C17H13ClN2O4/c1-9(21)14-8-11-10(5-6-13(23-2)15(11)24-14)17(22)20-12-4-3-7-19-16(12)18/h3-8H,1-2H3,(H,20,22) | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| PubMed
| n/a | n/a | 199 | n/a | n/a | n/a | n/a | n/a | n/a |
Celltech-Chiroscience Ltd
Curated by ChEMBL
| Assay Description
Inhibition of rolipram binding in rat brain tissue |
Bioorg Med Chem Lett 10: 2137-40 (2000)
BindingDB Entry DOI: 10.7270/Q2NP26MQ |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4C
(Rattus norvegicus) | BDBM50218247
(CHEMBL66798)Show SMILES COc1ccc(C(=O)Nc2c(Cl)cc(cc2Cl)C#N)c2cc(oc12)C(C)=O Show InChI InChI=1S/C19H12Cl2N2O4/c1-9(24)16-7-12-11(3-4-15(26-2)18(12)27-16)19(25)23-17-13(20)5-10(8-22)6-14(17)21/h3-7H,1-2H3,(H,23,25) | PDB
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UniChem
| PubMed
| n/a | n/a | 228 | n/a | n/a | n/a | n/a | n/a | n/a |
Celltech-Chiroscience Ltd
Curated by ChEMBL
| Assay Description
Inhibition of rolipram binding in rat brain tissue |
Bioorg Med Chem Lett 10: 2137-40 (2000)
BindingDB Entry DOI: 10.7270/Q2NP26MQ |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4C
(Rattus norvegicus) | BDBM50218248
(CHEMBL69776)Show InChI InChI=1S/C18H14ClNO4/c1-10(21)16-9-12-11(7-8-15(23-2)17(12)24-16)18(22)20-14-6-4-3-5-13(14)19/h3-9H,1-2H3,(H,20,22) | PDB
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| n/a | n/a | 248 | n/a | n/a | n/a | n/a | n/a | n/a |
Celltech-Chiroscience Ltd
Curated by ChEMBL
| Assay Description
Inhibition of rolipram binding to rat brain tissue |
Bioorg Med Chem Lett 10: 2137-40 (2000)
BindingDB Entry DOI: 10.7270/Q2NP26MQ |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4C
(Rattus norvegicus) | BDBM50218256
(CHEMBL70145)Show InChI InChI=1S/C17H14N2O4/c1-10(20)15-9-13-12(3-4-14(22-2)16(13)23-15)17(21)19-11-5-7-18-8-6-11/h3-9H,1-2H3,(H,18,19,21) | PDB
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UniChem
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| n/a | n/a | 250 | n/a | n/a | n/a | n/a | n/a | n/a |
Celltech-Chiroscience Ltd
Curated by ChEMBL
| Assay Description
Inhibition of rolipram binding in rat brain tissue |
Bioorg Med Chem Lett 10: 2137-40 (2000)
BindingDB Entry DOI: 10.7270/Q2NP26MQ |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D
(Homo sapiens (Human)) | BDBM50218254
(CHEMBL302799)Show SMILES COc1ccc(C(=O)Nc2c(Cl)cncc2Cl)c2c(C)c(oc12)C(C)=O Show InChI InChI=1S/C18H14Cl2N2O4/c1-8-14-10(18(24)22-15-11(19)6-21-7-12(15)20)4-5-13(25-3)17(14)26-16(8)9(2)23/h4-7H,1-3H3,(H,21,22,24) | PDB
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| n/a | n/a | 320 | n/a | n/a | n/a | n/a | n/a | n/a |
Celltech-Chiroscience Ltd
Curated by ChEMBL
| Assay Description
Inhibition of Phosphodiesterase 4 from human U937 cells |
Bioorg Med Chem Lett 10: 2137-40 (2000)
BindingDB Entry DOI: 10.7270/Q2NP26MQ |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D
(Homo sapiens (Human)) | BDBM50218250
(CHEMBL305176)Show SMILES COc1ccc(C(=O)N(C)c2c(Cl)cncc2Cl)c2cc(oc12)C(C)=O Show InChI InChI=1S/C18H14Cl2N2O4/c1-9(23)15-6-11-10(4-5-14(25-3)17(11)26-15)18(24)22(2)16-12(19)7-21-8-13(16)20/h4-8H,1-3H3 | PDB
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| n/a | n/a | 330 | n/a | n/a | n/a | n/a | n/a | n/a |
Celltech-Chiroscience Ltd
Curated by ChEMBL
| Assay Description
Inhibition of Phosphodiesterase 4 from human U937 cells |
Bioorg Med Chem Lett 10: 2137-40 (2000)
BindingDB Entry DOI: 10.7270/Q2NP26MQ |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D
(Homo sapiens (Human)) | BDBM50218251
(CHEMBL66285)Show InChI InChI=1S/C18H16N2O4/c1-10-5-4-8-19-17(10)20-18(22)12-6-7-14(23-3)16-13(12)9-15(24-16)11(2)21/h4-9H,1-3H3,(H,19,20,22) | PDB
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UniChem
| PubMed
| n/a | n/a | 452 | n/a | n/a | n/a | n/a | n/a | n/a |
Celltech-Chiroscience Ltd
Curated by ChEMBL
| Assay Description
Inhibition of Phosphodiesterase 4 from human U937 cells |
Bioorg Med Chem Lett 10: 2137-40 (2000)
BindingDB Entry DOI: 10.7270/Q2NP26MQ |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D
(Homo sapiens (Human)) | BDBM50218252
(CHEMBL308456)Show SMILES COc1ccc(C(=O)Nc2c(Cl)cncc2Cl)c2cc(oc12)C(O)=O Show InChI InChI=1S/C16H10Cl2N2O5/c1-24-11-3-2-7(8-4-12(16(22)23)25-14(8)11)15(21)20-13-9(17)5-19-6-10(13)18/h2-6H,1H3,(H,22,23)(H,19,20,21) | PDB
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Celltech-Chiroscience Ltd
Curated by ChEMBL
| Assay Description
Inhibition of Phosphodiesterase 4 from human U937 cells |
Bioorg Med Chem Lett 10: 2137-40 (2000)
BindingDB Entry DOI: 10.7270/Q2NP26MQ |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D
(Homo sapiens (Human)) | BDBM50218253
(CHEMBL70090)Show InChI InChI=1S/C17H13ClN2O4/c1-9(21)14-8-11-10(5-6-13(23-2)15(11)24-14)17(22)20-12-4-3-7-19-16(12)18/h3-8H,1-2H3,(H,20,22) | PDB
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| CHEMBL
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UniChem
| PubMed
| n/a | n/a | 875 | n/a | n/a | n/a | n/a | n/a | n/a |
Celltech-Chiroscience Ltd
Curated by ChEMBL
| Assay Description
Inhibition of Phosphodiesterase 4 from human U937 cells |
Bioorg Med Chem Lett 10: 2137-40 (2000)
BindingDB Entry DOI: 10.7270/Q2NP26MQ |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4C
(Rattus norvegicus) | BDBM50218252
(CHEMBL308456)Show SMILES COc1ccc(C(=O)Nc2c(Cl)cncc2Cl)c2cc(oc12)C(O)=O Show InChI InChI=1S/C16H10Cl2N2O5/c1-24-11-3-2-7(8-4-12(16(22)23)25-14(8)11)15(21)20-13-9(17)5-19-6-10(13)18/h2-6H,1H3,(H,22,23)(H,19,20,21) | PDB
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| n/a | n/a | 1.65E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Celltech-Chiroscience Ltd
Curated by ChEMBL
| Assay Description
Inhibition of rolipram binding to rat brain tissue at 20 uM |
Bioorg Med Chem Lett 10: 2137-40 (2000)
BindingDB Entry DOI: 10.7270/Q2NP26MQ |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4C
(Rattus norvegicus) | BDBM50218251
(CHEMBL66285)Show InChI InChI=1S/C18H16N2O4/c1-10-5-4-8-19-17(10)20-18(22)12-6-7-14(23-3)16-13(12)9-15(24-16)11(2)21/h4-9H,1-3H3,(H,19,20,22) | PDB
UniProtKB/SwissProt
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| CHEMBL
PC cid
PC sid
UniChem
| PubMed
| n/a | n/a | 1.85E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Celltech-Chiroscience Ltd
Curated by ChEMBL
| Assay Description
Inhibition of rolipram binding in rat brain tissue |
Bioorg Med Chem Lett 10: 2137-40 (2000)
BindingDB Entry DOI: 10.7270/Q2NP26MQ |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D
(Homo sapiens (Human)) | BDBM14361
((R,S)-Rolipram | 4-(3-cyclopentyloxy-4-methoxy-phe...)Show InChI InChI=1S/C16H21NO3/c1-19-14-7-6-11(12-9-16(18)17-10-12)8-15(14)20-13-4-2-3-5-13/h6-8,12-13H,2-5,9-10H2,1H3,(H,17,18) | PDB
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| PDB
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| n/a | n/a | 3.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Celltech-Chiroscience Ltd
Curated by ChEMBL
| Assay Description
Inhibition of Phosphodiesterase 4 from human U937 cells |
Bioorg Med Chem Lett 10: 2137-40 (2000)
BindingDB Entry DOI: 10.7270/Q2NP26MQ |
More data for this
Ligand-Target Pair | 
3D Structure (crystal) |
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