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PubMed code 11266159

Compile data set for download or QSAR
Found 63 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Glycogen synthase kinase-3 alpha


(Homo sapiens (Human))		BDBM8255
PNG
(3-[(3,5-dichloro-4-hydroxyphenyl)amino]-4-(3-nitro...)
Show SMILES Oc1c(Cl)cc(NC2=C(C(=O)NC2=O)c2cccc(c2)N(=O)=O)cc1Cl |t:7|
Show InChI InChI=1S/C16H9Cl2N3O5/c17-10-5-8(6-11(18)14(10)22)19-13-12(15(23)20-16(13)24)7-2-1-3-9(4-7)21(25)26/h1-6,22H,(H2,19,20,23,24)
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SmithKline Beecham Pharmaceuticals



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 10 uM ATP/ [gamma-33P] ATP. Aft...

Bioorg Med Chem Lett 11: 635-9 (2001)


Article DOI: 10.1016/s0960-894x(00)00721-6
BindingDB Entry DOI: 10.7270/Q2QV3JRC
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 alpha


(Homo sapiens (Human))		BDBM8271
PNG
(2-chloro-5-{[4-(3-nitrophenyl)-2,5-dioxo-2,5-dihyd...)
Show SMILES OC(=O)c1cc(NC2=C(C(=O)NC2=O)c2cccc(c2)N(=O)=O)ccc1Cl |t:7|
Show InChI InChI=1S/C17H10ClN3O6/c18-12-5-4-9(7-11(12)17(24)25)19-14-13(15(22)20-16(14)23)8-2-1-3-10(6-8)21(26)27/h1-7H,(H,24,25)(H2,19,20,22,23)
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SmithKline Beecham Pharmaceuticals



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 10 uM ATP/ [gamma-33P] ATP. Aft...

Bioorg Med Chem Lett 11: 635-9 (2001)


Article DOI: 10.1016/s0960-894x(00)00721-6
BindingDB Entry DOI: 10.7270/Q2QV3JRC
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 alpha


(Homo sapiens (Human))		BDBM8268
PNG
(2-chloro-5-{[4-(2-nitrophenyl)-2,5-dioxo-2,5-dihyd...)
Show SMILES OC(=O)c1cc(NC2=C(C(=O)NC2=O)c2ccccc2N(=O)=O)ccc1Cl |t:7|
Show InChI InChI=1S/C17H10ClN3O6/c18-11-6-5-8(7-10(11)17(24)25)19-14-13(15(22)20-16(14)23)9-3-1-2-4-12(9)21(26)27/h1-7H,(H,24,25)(H2,19,20,22,23)
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SmithKline Beecham Pharmaceuticals



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 10 uM ATP/ [gamma-33P] ATP. Aft...

Bioorg Med Chem Lett 11: 635-9 (2001)


Article DOI: 10.1016/s0960-894x(00)00721-6
BindingDB Entry DOI: 10.7270/Q2QV3JRC
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 alpha


(Homo sapiens (Human))		BDBM8252
PNG
(3-[(3,5-dichloro-4-hydroxyphenyl)amino]-4-(2-nitro...)
Show SMILES Oc1c(Cl)cc(NC2=C(C(=O)NC2=O)c2ccccc2N(=O)=O)cc1Cl |t:7|
Show InChI InChI=1S/C16H9Cl2N3O5/c17-9-5-7(6-10(18)14(9)22)19-13-12(15(23)20-16(13)24)8-3-1-2-4-11(8)21(25)26/h1-6,22H,(H2,19,20,23,24)
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SmithKline Beecham Pharmaceuticals



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 10 uM ATP/ [gamma-33P] ATP. Aft...

Bioorg Med Chem Lett 11: 635-9 (2001)


Article DOI: 10.1016/s0960-894x(00)00721-6
BindingDB Entry DOI: 10.7270/Q2QV3JRC
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 alpha


(Homo sapiens (Human))		BDBM8253
PNG
(3-(3-chlorophenyl)-4-[(3,5-dichloro-4-hydroxypheny...)
Show SMILES Oc1c(Cl)cc(NC2=C(C(=O)NC2=O)c2cccc(Cl)c2)cc1Cl |t:7|
Show InChI InChI=1S/C16H9Cl3N2O3/c17-8-3-1-2-7(4-8)12-13(16(24)21-15(12)23)20-9-5-10(18)14(22)11(19)6-9/h1-6,22H,(H2,20,21,23,24)
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SmithKline Beecham Pharmaceuticals



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 10 uM ATP/ [gamma-33P] ATP. Aft...

Bioorg Med Chem Lett 11: 635-9 (2001)


Article DOI: 10.1016/s0960-894x(00)00721-6
BindingDB Entry DOI: 10.7270/Q2QV3JRC
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 alpha


(Homo sapiens (Human))		BDBM8247
PNG
(3-[(3-chloro-4-hydroxyphenyl)amino]-4-(3-nitrophen...)
Show SMILES Oc1ccc(NC2=C(C(=O)NC2=O)c2cccc(c2)N(=O)=O)cc1Cl |t:6|
Show InChI InChI=1S/C16H10ClN3O5/c17-11-7-9(4-5-12(11)21)18-14-13(15(22)19-16(14)23)8-2-1-3-10(6-8)20(24)25/h1-7,21H,(H2,18,19,22,23)
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SmithKline Beecham Pharmaceuticals



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 10 uM ATP/ [gamma-33P] ATP. Aft...

Bioorg Med Chem Lett 11: 635-9 (2001)


Article DOI: 10.1016/s0960-894x(00)00721-6
BindingDB Entry DOI: 10.7270/Q2QV3JRC
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 alpha


(Homo sapiens (Human))		BDBM8229
PNG
(3-[(3-chlorophenyl)amino]-4-(3-nitrophenyl)-2,5-di...)
Show SMILES Clc1cccc(NC2=C(C(=O)NC2=O)c2cccc(c2)N(=O)=O)c1 |t:7|
Show InChI InChI=1S/C16H10ClN3O4/c17-10-4-2-5-11(8-10)18-14-13(15(21)19-16(14)22)9-3-1-6-12(7-9)20(23)24/h1-8H,(H2,18,19,21,22)
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SmithKline Beecham Pharmaceuticals



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 10 uM ATP/ [gamma-33P] ATP. Aft...

Bioorg Med Chem Lett 11: 635-9 (2001)


Article DOI: 10.1016/s0960-894x(00)00721-6
BindingDB Entry DOI: 10.7270/Q2QV3JRC
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 alpha


(Homo sapiens (Human))		BDBM8258
PNG
(3-[(3,5-dichloro-4-hydroxyphenyl)amino]-4-(4-nitro...)
Show SMILES Oc1c(Cl)cc(NC2=C(C(=O)NC2=O)c2ccc(cc2)N(=O)=O)cc1Cl |t:7|
Show InChI InChI=1S/C16H9Cl2N3O5/c17-10-5-8(6-11(18)14(10)22)19-13-12(15(23)20-16(13)24)7-1-3-9(4-2-7)21(25)26/h1-6,22H,(H2,19,20,23,24)
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SmithKline Beecham Pharmaceuticals



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 10 uM ATP/ [gamma-33P] ATP. Aft...

Bioorg Med Chem Lett 11: 635-9 (2001)


Article DOI: 10.1016/s0960-894x(00)00721-6
BindingDB Entry DOI: 10.7270/Q2QV3JRC
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 alpha


(Homo sapiens (Human))		BDBM8267
PNG
(2-chloro-5-{[4-(2-chlorophenyl)-2,5-dioxo-2,5-dihy...)
Show SMILES OC(=O)c1cc(NC2=C(C(=O)NC2=O)c2ccccc2Cl)ccc1Cl |t:7|
Show InChI InChI=1S/C17H10Cl2N2O4/c18-11-4-2-1-3-9(11)13-14(16(23)21-15(13)22)20-8-5-6-12(19)10(7-8)17(24)25/h1-7H,(H,24,25)(H2,20,21,22,23)
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SmithKline Beecham Pharmaceuticals



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 10 uM ATP/ [gamma-33P] ATP. Aft...

Bioorg Med Chem Lett 11: 635-9 (2001)


Article DOI: 10.1016/s0960-894x(00)00721-6
BindingDB Entry DOI: 10.7270/Q2QV3JRC
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 alpha


(Homo sapiens (Human))		BDBM8269
PNG
(2-chloro-5-{[4-(3-chlorophenyl)-2,5-dioxo-2,5-dihy...)
Show SMILES OC(=O)c1cc(NC2=C(C(=O)NC2=O)c2cccc(Cl)c2)ccc1Cl |t:7|
Show InChI InChI=1S/C17H10Cl2N2O4/c18-9-3-1-2-8(6-9)13-14(16(23)21-15(13)22)20-10-4-5-12(19)11(7-10)17(24)25/h1-7H,(H,24,25)(H2,20,21,22,23)
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SmithKline Beecham Pharmaceuticals



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 10 uM ATP/ [gamma-33P] ATP. Aft...

Bioorg Med Chem Lett 11: 635-9 (2001)


Article DOI: 10.1016/s0960-894x(00)00721-6
BindingDB Entry DOI: 10.7270/Q2QV3JRC
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 alpha


(Homo sapiens (Human))		BDBM8263
PNG
(3-{[4-(3-nitrophenyl)-2,5-dioxo-2,5-dihydro-1H-pyr...)
Show SMILES OC(=O)c1cccc(NC2=C(C(=O)NC2=O)c2cccc(c2)N(=O)=O)c1 |t:9|
Show InChI InChI=1S/C17H11N3O6/c21-15-13(9-3-2-6-12(8-9)20(25)26)14(16(22)19-15)18-11-5-1-4-10(7-11)17(23)24/h1-8H,(H,23,24)(H2,18,19,21,22)
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SmithKline Beecham Pharmaceuticals



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 10 uM ATP/ [gamma-33P] ATP. Aft...

Bioorg Med Chem Lett 11: 635-9 (2001)


Article DOI: 10.1016/s0960-894x(00)00721-6
BindingDB Entry DOI: 10.7270/Q2QV3JRC
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 alpha


(Homo sapiens (Human))		BDBM8251
PNG
(3-[(3,5-dichloro-4-hydroxyphenyl)amino]-4-(2-metho...)
Show SMILES COc1ccccc1C1=C(Nc2cc(Cl)c(O)c(Cl)c2)C(=O)NC1=O |c:9|
Show InChI InChI=1S/C17H12Cl2N2O4/c1-25-12-5-3-2-4-9(12)13-14(17(24)21-16(13)23)20-8-6-10(18)15(22)11(19)7-8/h2-7,22H,1H3,(H2,20,21,23,24)
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SmithKline Beecham Pharmaceuticals



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 10 uM ATP/ [gamma-33P] ATP. Aft...

Bioorg Med Chem Lett 11: 635-9 (2001)


Article DOI: 10.1016/s0960-894x(00)00721-6
BindingDB Entry DOI: 10.7270/Q2QV3JRC
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 alpha


(Homo sapiens (Human))		BDBM8257
PNG
(3-[(3,5-dichloro-4-hydroxyphenyl)amino]-4-(4-metho...)
Show SMILES COc1ccc(cc1)C1=C(Nc2cc(Cl)c(O)c(Cl)c2)C(=O)NC1=O |c:9|
Show InChI InChI=1S/C17H12Cl2N2O4/c1-25-10-4-2-8(3-5-10)13-14(17(24)21-16(13)23)20-9-6-11(18)15(22)12(19)7-9/h2-7,22H,1H3,(H2,20,21,23,24)
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SmithKline Beecham Pharmaceuticals



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 10 uM ATP/ [gamma-33P] ATP. Aft...

Bioorg Med Chem Lett 11: 635-9 (2001)


Article DOI: 10.1016/s0960-894x(00)00721-6
BindingDB Entry DOI: 10.7270/Q2QV3JRC
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 alpha


(Homo sapiens (Human))		BDBM8270
PNG
(2-chloro-5-{[4-(3-methoxyphenyl)-2,5-dioxo-2,5-dih...)
Show SMILES COc1cccc(c1)C1=C(Nc2ccc(Cl)c(c2)C(O)=O)C(=O)NC1=O |c:9|
Show InChI InChI=1S/C18H13ClN2O5/c1-26-11-4-2-3-9(7-11)14-15(17(23)21-16(14)22)20-10-5-6-13(19)12(8-10)18(24)25/h2-8H,1H3,(H,24,25)(H2,20,21,22,23)
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SmithKline Beecham Pharmaceuticals



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 10 uM ATP/ [gamma-33P] ATP. Aft...

Bioorg Med Chem Lett 11: 635-9 (2001)


Article DOI: 10.1016/s0960-894x(00)00721-6
BindingDB Entry DOI: 10.7270/Q2QV3JRC
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 alpha


(Homo sapiens (Human))		BDBM8256
PNG
(3-(4-chlorophenyl)-4-[(3,5-dichloro-4-hydroxypheny...)
Show SMILES Oc1c(Cl)cc(NC2=C(C(=O)NC2=O)c2ccc(Cl)cc2)cc1Cl |t:7|
Show InChI InChI=1S/C16H9Cl3N2O3/c17-8-3-1-7(2-4-8)12-13(16(24)21-15(12)23)20-9-5-10(18)14(22)11(19)6-9/h1-6,22H,(H2,20,21,23,24)
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SmithKline Beecham Pharmaceuticals



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 10 uM ATP/ [gamma-33P] ATP. Aft...

Bioorg Med Chem Lett 11: 635-9 (2001)


Article DOI: 10.1016/s0960-894x(00)00721-6
BindingDB Entry DOI: 10.7270/Q2QV3JRC
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 alpha


(Homo sapiens (Human))		BDBM8250
PNG
(3-(2-chlorophenyl)-4-[(3,5-dichloro-4-hydroxypheny...)
Show SMILES Oc1c(Cl)cc(NC2=C(C(=O)NC2=O)c2ccccc2Cl)cc1Cl |t:7|
Show InChI InChI=1S/C16H9Cl3N2O3/c17-9-4-2-1-3-8(9)12-13(16(24)21-15(12)23)20-7-5-10(18)14(22)11(19)6-7/h1-6,22H,(H2,20,21,23,24)
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SmithKline Beecham Pharmaceuticals



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 10 uM ATP/ [gamma-33P] ATP. Aft...

Bioorg Med Chem Lett 11: 635-9 (2001)


Article DOI: 10.1016/s0960-894x(00)00721-6
BindingDB Entry DOI: 10.7270/Q2QV3JRC
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 alpha


(Homo sapiens (Human))		BDBM8246
PNG
(3-[(3-chloro-4-hydroxyphenyl)amino]-4-(3-chlorophe...)
Show SMILES Oc1ccc(NC2=C(C(=O)NC2=O)c2cccc(Cl)c2)cc1Cl |t:6|
Show InChI InChI=1S/C16H10Cl2N2O3/c17-9-3-1-2-8(6-9)13-14(16(23)20-15(13)22)19-10-4-5-12(21)11(18)7-10/h1-7,21H,(H2,19,20,22,23)
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SmithKline Beecham Pharmaceuticals



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 10 uM ATP/ [gamma-33P] ATP. Aft...

Bioorg Med Chem Lett 11: 635-9 (2001)


Article DOI: 10.1016/s0960-894x(00)00721-6
BindingDB Entry DOI: 10.7270/Q2QV3JRC
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 alpha


(Homo sapiens (Human))		BDBM8227
PNG
(3-[(3-chlorophenyl)amino]-4-(2-nitrophenyl)-2,5-di...)
Show SMILES Clc1cccc(NC2=C(C(=O)NC2=O)c2ccccc2N(=O)=O)c1 |t:7|
Show InChI InChI=1S/C16H10ClN3O4/c17-9-4-3-5-10(8-9)18-14-13(15(21)19-16(14)22)11-6-1-2-7-12(11)20(23)24/h1-8H,(H2,18,19,21,22)
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SmithKline Beecham Pharmaceuticals



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 10 uM ATP/ [gamma-33P] ATP. Aft...

Bioorg Med Chem Lett 11: 635-9 (2001)


Article DOI: 10.1016/s0960-894x(00)00721-6
BindingDB Entry DOI: 10.7270/Q2QV3JRC
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 alpha


(Homo sapiens (Human))		BDBM8272
PNG
(2-chloro-5-{[4-(4-chlorophenyl)-2,5-dioxo-2,5-dihy...)
Show SMILES OC(=O)c1cc(NC2=C(C(=O)NC2=O)c2ccc(Cl)cc2)ccc1Cl |t:7|
Show InChI InChI=1S/C17H10Cl2N2O4/c18-9-3-1-8(2-4-9)13-14(16(23)21-15(13)22)20-10-5-6-12(19)11(7-10)17(24)25/h1-7H,(H,24,25)(H2,20,21,22,23)
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n/an/a 109n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 10 uM ATP/ [gamma-33P] ATP. Aft...

Bioorg Med Chem Lett 11: 635-9 (2001)


Article DOI: 10.1016/s0960-894x(00)00721-6
BindingDB Entry DOI: 10.7270/Q2QV3JRC
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 alpha


(Homo sapiens (Human))		BDBM8275
PNG
(3-(2-methoxyphenyl)-4-{[4-(methylsulfanyl)phenyl]a...)
Show SMILES COc1ccccc1C1=C(Nc2ccc(SC)cc2)C(=O)NC1=O |c:9|
Show InChI InChI=1S/C18H16N2O3S/c1-23-14-6-4-3-5-13(14)15-16(18(22)20-17(15)21)19-11-7-9-12(24-2)10-8-11/h3-10H,1-2H3,(H2,19,20,21,22)
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n/an/a 110n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 10 uM ATP/ [gamma-33P] ATP. Aft...

Bioorg Med Chem Lett 11: 635-9 (2001)


Article DOI: 10.1016/s0960-894x(00)00721-6
BindingDB Entry DOI: 10.7270/Q2QV3JRC
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 alpha


(Homo sapiens (Human))		BDBM8226
PNG
(3-[(3-chlorophenyl)amino]-4-(2-methoxyphenyl)-2,5-...)
Show SMILES COc1ccccc1C1=C(Nc2cccc(Cl)c2)C(=O)NC1=O |c:9|
Show InChI InChI=1S/C17H13ClN2O3/c1-23-13-8-3-2-7-12(13)14-15(17(22)20-16(14)21)19-11-6-4-5-10(18)9-11/h2-9H,1H3,(H2,19,20,21,22)
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n/an/a 114n/an/an/an/a7.022



SmithKline Beecham Pharmaceuticals



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 10 uM ATP/ [gamma-33P] ATP. Aft...

Bioorg Med Chem Lett 11: 635-9 (2001)


Article DOI: 10.1016/s0960-894x(00)00721-6
BindingDB Entry DOI: 10.7270/Q2QV3JRC
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 alpha


(Homo sapiens (Human))		BDBM8241
PNG
(3-[(4-hydroxyphenyl)amino]-4-(3-nitrophenyl)-2,5-d...)
Show SMILES Oc1ccc(NC2=C(C(=O)NC2=O)c2cccc(c2)N(=O)=O)cc1 |t:6|
Show InChI InChI=1S/C16H11N3O5/c20-12-6-4-10(5-7-12)17-14-13(15(21)18-16(14)22)9-2-1-3-11(8-9)19(23)24/h1-8,20H,(H2,17,18,21,22)
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n/an/a 123n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 10 uM ATP/ [gamma-33P] ATP. Aft...

Bioorg Med Chem Lett 11: 635-9 (2001)


Article DOI: 10.1016/s0960-894x(00)00721-6
BindingDB Entry DOI: 10.7270/Q2QV3JRC
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 alpha


(Homo sapiens (Human))		BDBM8261
PNG
(3-{[4-(3-chlorophenyl)-2,5-dioxo-2,5-dihydro-1H-py...)
Show SMILES OC(=O)c1cccc(NC2=C(C(=O)NC2=O)c2cccc(Cl)c2)c1 |t:9|
Show InChI InChI=1S/C17H11ClN2O4/c18-11-5-1-3-9(7-11)13-14(16(22)20-15(13)21)19-12-6-2-4-10(8-12)17(23)24/h1-8H,(H,23,24)(H2,19,20,21,22)
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SmithKline Beecham Pharmaceuticals



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 10 uM ATP/ [gamma-33P] ATP. Aft...

Bioorg Med Chem Lett 11: 635-9 (2001)


Article DOI: 10.1016/s0960-894x(00)00721-6
BindingDB Entry DOI: 10.7270/Q2QV3JRC
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 alpha


(Homo sapiens (Human))		BDBM8260
PNG
(3-{[4-(2-chlorophenyl)-2,5-dioxo-2,5-dihydro-1H-py...)
Show SMILES OC(=O)c1cccc(NC2=C(C(=O)NC2=O)c2ccccc2Cl)c1 |t:9|
Show InChI InChI=1S/C17H11ClN2O4/c18-12-7-2-1-6-11(12)13-14(16(22)20-15(13)21)19-10-5-3-4-9(8-10)17(23)24/h1-8H,(H,23,24)(H2,19,20,21,22)
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SmithKline Beecham Pharmaceuticals



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 10 uM ATP/ [gamma-33P] ATP. Aft...

Bioorg Med Chem Lett 11: 635-9 (2001)


Article DOI: 10.1016/s0960-894x(00)00721-6
BindingDB Entry DOI: 10.7270/Q2QV3JRC
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 alpha


(Homo sapiens (Human))		BDBM8244
PNG
(3-[(3-chloro-4-hydroxyphenyl)amino]-4-(2-methoxyph...)
Show SMILES COc1ccccc1C1=C(Nc2ccc(O)c(Cl)c2)C(=O)NC1=O |c:9|
Show InChI InChI=1S/C17H13ClN2O4/c1-24-13-5-3-2-4-10(13)14-15(17(23)20-16(14)22)19-9-6-7-12(21)11(18)8-9/h2-8,21H,1H3,(H2,19,20,22,23)
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SmithKline Beecham Pharmaceuticals



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 10 uM ATP/ [gamma-33P] ATP. Aft...

Bioorg Med Chem Lett 11: 635-9 (2001)


Article DOI: 10.1016/s0960-894x(00)00721-6
BindingDB Entry DOI: 10.7270/Q2QV3JRC
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 alpha


(Homo sapiens (Human))		BDBM8221
PNG
(3-(3-nitrophenyl)-4-(phenylamino)-2,5-dihydro-1H-p...)
Show SMILES O=C1NC(=O)C(=C1Nc1ccccc1)c1cccc(c1)N(=O)=O |c:5|
Show InChI InChI=1S/C16H11N3O4/c20-15-13(10-5-4-8-12(9-10)19(22)23)14(16(21)18-15)17-11-6-2-1-3-7-11/h1-9H,(H2,17,18,20,21)
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n/an/a 141n/an/an/an/a7.022



SmithKline Beecham Pharmaceuticals



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 10 uM ATP/ [gamma-33P] ATP. Aft...

Bioorg Med Chem Lett 11: 635-9 (2001)


Article DOI: 10.1016/s0960-894x(00)00721-6
BindingDB Entry DOI: 10.7270/Q2QV3JRC
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 alpha


(Homo sapiens (Human))		BDBM8254
PNG
(3-[(3,5-dichloro-4-hydroxyphenyl)amino]-4-(3-metho...)
Show SMILES COc1cccc(c1)C1=C(Nc2cc(Cl)c(O)c(Cl)c2)C(=O)NC1=O |c:9|
Show InChI InChI=1S/C17H12Cl2N2O4/c1-25-10-4-2-3-8(5-10)13-14(17(24)21-16(13)23)20-9-6-11(18)15(22)12(19)7-9/h2-7,22H,1H3,(H2,20,21,23,24)
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SmithKline Beecham Pharmaceuticals



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 10 uM ATP/ [gamma-33P] ATP. Aft...

Bioorg Med Chem Lett 11: 635-9 (2001)


Article DOI: 10.1016/s0960-894x(00)00721-6
BindingDB Entry DOI: 10.7270/Q2QV3JRC
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 alpha


(Homo sapiens (Human))		BDBM8266
PNG
(2-chloro-5-[(2,5-dioxo-4-phenyl-2,5-dihydro-1H-pyr...)
Show SMILES OC(=O)c1cc(NC2=C(C(=O)NC2=O)c2ccccc2)ccc1Cl |t:7|
Show InChI InChI=1S/C17H11ClN2O4/c18-12-7-6-10(8-11(12)17(23)24)19-14-13(15(21)20-16(14)22)9-4-2-1-3-5-9/h1-8H,(H,23,24)(H2,19,20,21,22)
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n/an/a 143n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 10 uM ATP/ [gamma-33P] ATP. Aft...

Bioorg Med Chem Lett 11: 635-9 (2001)


Article DOI: 10.1016/s0960-894x(00)00721-6
BindingDB Entry DOI: 10.7270/Q2QV3JRC
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 alpha


(Homo sapiens (Human))		BDBM8249
PNG
(3-[(3,5-dichloro-4-hydroxyphenyl)amino]-4-phenyl-2...)
Show SMILES Oc1c(Cl)cc(NC2=C(C(=O)NC2=O)c2ccccc2)cc1Cl |t:7|
Show InChI InChI=1S/C16H10Cl2N2O3/c17-10-6-9(7-11(18)14(10)21)19-13-12(15(22)20-16(13)23)8-4-2-1-3-5-8/h1-7,21H,(H2,19,20,22,23)
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n/an/a 149n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 10 uM ATP/ [gamma-33P] ATP. Aft...

Bioorg Med Chem Lett 11: 635-9 (2001)


Article DOI: 10.1016/s0960-894x(00)00721-6
BindingDB Entry DOI: 10.7270/Q2QV3JRC
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 alpha


(Homo sapiens (Human))		BDBM8243
PNG
(3-[(3-chloro-4-hydroxyphenyl)amino]-4-(2-chlorophe...)
Show SMILES Oc1ccc(NC2=C(C(=O)NC2=O)c2ccccc2Cl)cc1Cl |t:6|
Show InChI InChI=1S/C16H10Cl2N2O3/c17-10-4-2-1-3-9(10)13-14(16(23)20-15(13)22)19-8-5-6-12(21)11(18)7-8/h1-7,21H,(H2,19,20,22,23)
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SmithKline Beecham Pharmaceuticals



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 10 uM ATP/ [gamma-33P] ATP. Aft...

Bioorg Med Chem Lett 11: 635-9 (2001)


Article DOI: 10.1016/s0960-894x(00)00721-6
BindingDB Entry DOI: 10.7270/Q2QV3JRC
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 alpha


(Homo sapiens (Human))		BDBM8278
PNG
(3-{[4-(methylsulfanyl)phenyl]amino}-4-(3-nitrophen...)
Show SMILES CSc1ccc(NC2=C(C(=O)NC2=O)c2cccc(c2)N(=O)=O)cc1 |t:7|
Show InChI InChI=1S/C17H13N3O4S/c1-25-13-7-5-11(6-8-13)18-15-14(16(21)19-17(15)22)10-3-2-4-12(9-10)20(23)24/h2-9H,1H3,(H2,18,19,21,22)
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n/an/a 152n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 10 uM ATP/ [gamma-33P] ATP. Aft...

Bioorg Med Chem Lett 11: 635-9 (2001)


Article DOI: 10.1016/s0960-894x(00)00721-6
BindingDB Entry DOI: 10.7270/Q2QV3JRC
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 alpha


(Homo sapiens (Human))		BDBM8231
PNG
(3-[(3-chlorophenyl)amino]-4-(4-methoxyphenyl)-2,5-...)
Show SMILES COc1ccc(cc1)C1=C(Nc2cccc(Cl)c2)C(=O)NC1=O |c:9|
Show InChI InChI=1S/C17H13ClN2O3/c1-23-13-7-5-10(6-8-13)14-15(17(22)20-16(14)21)19-12-4-2-3-11(18)9-12/h2-9H,1H3,(H2,19,20,21,22)
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n/an/a 156n/an/an/an/a7.022



SmithKline Beecham Pharmaceuticals



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 10 uM ATP/ [gamma-33P] ATP. Aft...

Bioorg Med Chem Lett 11: 635-9 (2001)


Article DOI: 10.1016/s0960-894x(00)00721-6
BindingDB Entry DOI: 10.7270/Q2QV3JRC
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 alpha


(Homo sapiens (Human))		BDBM8274
PNG
(3-(2-chlorophenyl)-4-{[4-(methylsulfanyl)phenyl]am...)
Show SMILES CSc1ccc(NC2=C(C(=O)NC2=O)c2ccccc2Cl)cc1 |t:7|
Show InChI InChI=1S/C17H13ClN2O2S/c1-23-11-8-6-10(7-9-11)19-15-14(16(21)20-17(15)22)12-4-2-3-5-13(12)18/h2-9H,1H3,(H2,19,20,21,22)
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n/an/a 161n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 10 uM ATP/ [gamma-33P] ATP. Aft...

Bioorg Med Chem Lett 11: 635-9 (2001)


Article DOI: 10.1016/s0960-894x(00)00721-6
BindingDB Entry DOI: 10.7270/Q2QV3JRC
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 alpha


(Homo sapiens (Human))		BDBM8248
PNG
(3-[(3-chloro-4-hydroxyphenyl)amino]-4-(4-chlorophe...)
Show SMILES Oc1ccc(NC2=C(C(=O)NC2=O)c2ccc(Cl)cc2)cc1Cl |t:6|
Show InChI InChI=1S/C16H10Cl2N2O3/c17-9-3-1-8(2-4-9)13-14(16(23)20-15(13)22)19-10-5-6-12(21)11(18)7-10/h1-7,21H,(H2,19,20,22,23)
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SmithKline Beecham Pharmaceuticals



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 10 uM ATP/ [gamma-33P] ATP. Aft...

Bioorg Med Chem Lett 11: 635-9 (2001)


Article DOI: 10.1016/s0960-894x(00)00721-6
BindingDB Entry DOI: 10.7270/Q2QV3JRC
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 alpha


(Homo sapiens (Human))		BDBM8264
PNG
(3-{[4-(4-chlorophenyl)-2,5-dioxo-2,5-dihydro-1H-py...)
Show SMILES OC(=O)c1cccc(NC2=C(C(=O)NC2=O)c2ccc(Cl)cc2)c1 |t:9|
Show InChI InChI=1S/C17H11ClN2O4/c18-11-6-4-9(5-7-11)13-14(16(22)20-15(13)21)19-12-3-1-2-10(8-12)17(23)24/h1-8H,(H,23,24)(H2,19,20,21,22)
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SmithKline Beecham Pharmaceuticals



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 10 uM ATP/ [gamma-33P] ATP. Aft...

Bioorg Med Chem Lett 11: 635-9 (2001)


Article DOI: 10.1016/s0960-894x(00)00721-6
BindingDB Entry DOI: 10.7270/Q2QV3JRC
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 alpha


(Homo sapiens (Human))		BDBM8225
PNG
(3-(2-chlorophenyl)-4-[(3-chlorophenyl)amino]-2,5-d...)
Show SMILES Clc1cccc(NC2=C(C(=O)NC2=O)c2ccccc2Cl)c1 |t:7|
Show InChI InChI=1S/C16H10Cl2N2O2/c17-9-4-3-5-10(8-9)19-14-13(15(21)20-16(14)22)11-6-1-2-7-12(11)18/h1-8H,(H2,19,20,21,22)
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n/an/a 195n/an/an/an/a7.022



SmithKline Beecham Pharmaceuticals



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 10 uM ATP/ [gamma-33P] ATP. Aft...

Bioorg Med Chem Lett 11: 635-9 (2001)


Article DOI: 10.1016/s0960-894x(00)00721-6
BindingDB Entry DOI: 10.7270/Q2QV3JRC
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 alpha


(Homo sapiens (Human))		BDBM8262
PNG
(3-{[4-(3-methoxyphenyl)-2,5-dioxo-2,5-dihydro-1H-p...)
Show SMILES COc1cccc(c1)C1=C(Nc2cccc(c2)C(O)=O)C(=O)NC1=O |c:9|
Show InChI InChI=1S/C18H14N2O5/c1-25-13-7-3-4-10(9-13)14-15(17(22)20-16(14)21)19-12-6-2-5-11(8-12)18(23)24/h2-9H,1H3,(H,23,24)(H2,19,20,21,22)
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SmithKline Beecham Pharmaceuticals



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 10 uM ATP/ [gamma-33P] ATP. Aft...

Bioorg Med Chem Lett 11: 635-9 (2001)


Article DOI: 10.1016/s0960-894x(00)00721-6
BindingDB Entry DOI: 10.7270/Q2QV3JRC
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 alpha


(Homo sapiens (Human))		BDBM8277
PNG
(3-(3-methoxyphenyl)-4-{[4-(methylsulfanyl)phenyl]a...)
Show SMILES COc1cccc(c1)C1=C(Nc2ccc(SC)cc2)C(=O)NC1=O |c:9|
Show InChI InChI=1S/C18H16N2O3S/c1-23-13-5-3-4-11(10-13)15-16(18(22)20-17(15)21)19-12-6-8-14(24-2)9-7-12/h3-10H,1-2H3,(H2,19,20,21,22)
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SmithKline Beecham Pharmaceuticals



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 10 uM ATP/ [gamma-33P] ATP. Aft...

Bioorg Med Chem Lett 11: 635-9 (2001)


Article DOI: 10.1016/s0960-894x(00)00721-6
BindingDB Entry DOI: 10.7270/Q2QV3JRC
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 alpha


(Homo sapiens (Human))		BDBM8265
PNG
(3-{[4-(4-methoxyphenyl)-2,5-dioxo-2,5-dihydro-1H-p...)
Show SMILES COc1ccc(cc1)C1=C(Nc2cccc(c2)C(O)=O)C(=O)NC1=O |c:9|
Show InChI InChI=1S/C18H14N2O5/c1-25-13-7-5-10(6-8-13)14-15(17(22)20-16(14)21)19-12-4-2-3-11(9-12)18(23)24/h2-9H,1H3,(H,23,24)(H2,19,20,21,22)
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SmithKline Beecham Pharmaceuticals



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 10 uM ATP/ [gamma-33P] ATP. Aft...

Bioorg Med Chem Lett 11: 635-9 (2001)


Article DOI: 10.1016/s0960-894x(00)00721-6
BindingDB Entry DOI: 10.7270/Q2QV3JRC
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 alpha


(Homo sapiens (Human))		BDBM8220
PNG
(3-(2-methoxyphenyl)-4-(phenylamino)-2,5-dihydro-1H...)
Show SMILES COc1ccccc1C1=C(Nc2ccccc2)C(=O)NC1=O |c:9|
Show InChI InChI=1S/C17H14N2O3/c1-22-13-10-6-5-9-12(13)14-15(17(21)19-16(14)20)18-11-7-3-2-4-8-11/h2-10H,1H3,(H2,18,19,20,21)
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n/an/a 216n/an/an/an/a7.022



SmithKline Beecham Pharmaceuticals



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 10 uM ATP/ [gamma-33P] ATP. Aft...

Bioorg Med Chem Lett 11: 635-9 (2001)


Article DOI: 10.1016/s0960-894x(00)00721-6
BindingDB Entry DOI: 10.7270/Q2QV3JRC
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 alpha


(Homo sapiens (Human))		BDBM8219
PNG
(3-(2-chlorophenyl)-4-(phenylamino)-2,5-dihydro-1H-...)
Show SMILES Clc1ccccc1C1=C(Nc2ccccc2)C(=O)NC1=O |c:8|
Show InChI InChI=1S/C16H11ClN2O2/c17-12-9-5-4-8-11(12)13-14(16(21)19-15(13)20)18-10-6-2-1-3-7-10/h1-9H,(H2,18,19,20,21)
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n/an/a 216n/an/an/an/a7.022



SmithKline Beecham Pharmaceuticals



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 10 uM ATP/ [gamma-33P] ATP. Aft...

Bioorg Med Chem Lett 11: 635-9 (2001)


Article DOI: 10.1016/s0960-894x(00)00721-6
BindingDB Entry DOI: 10.7270/Q2QV3JRC
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 alpha


(Homo sapiens (Human))		BDBM8238
PNG
(3-[(3-hydroxyphenyl)amino]-4-(3-nitrophenyl)-2,5-d...)
Show SMILES Oc1cccc(NC2=C(C(=O)NC2=O)c2cccc(c2)N(=O)=O)c1 |t:7|
Show InChI InChI=1S/C16H11N3O5/c20-12-6-2-4-10(8-12)17-14-13(15(21)18-16(14)22)9-3-1-5-11(7-9)19(23)24/h1-8,20H,(H2,17,18,21,22)
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SmithKline Beecham Pharmaceuticals



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 10 uM ATP/ [gamma-33P] ATP. Aft...

Bioorg Med Chem Lett 11: 635-9 (2001)


Article DOI: 10.1016/s0960-894x(00)00721-6
BindingDB Entry DOI: 10.7270/Q2QV3JRC
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 alpha


(Homo sapiens (Human))		BDBM8280
PNG
(3-(4-methoxyphenyl)-4-{[4-(methylsulfanyl)phenyl]a...)
Show SMILES COc1ccc(cc1)C1=C(Nc2ccc(SC)cc2)C(=O)NC1=O |c:9|
Show InChI InChI=1S/C18H16N2O3S/c1-23-13-7-3-11(4-8-13)15-16(18(22)20-17(15)21)19-12-5-9-14(24-2)10-6-12/h3-10H,1-2H3,(H2,19,20,21,22)
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SmithKline Beecham Pharmaceuticals



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 10 uM ATP/ [gamma-33P] ATP. Aft...

Bioorg Med Chem Lett 11: 635-9 (2001)


Article DOI: 10.1016/s0960-894x(00)00721-6
BindingDB Entry DOI: 10.7270/Q2QV3JRC
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 alpha


(Homo sapiens (Human))		BDBM8235
PNG
(3-[(3-hydroxyphenyl)amino]-4-(2-nitrophenyl)-2,5-d...)
Show SMILES Oc1cccc(NC2=C(C(=O)NC2=O)c2ccccc2N(=O)=O)c1 |t:7|
Show InChI InChI=1S/C16H11N3O5/c20-10-5-3-4-9(8-10)17-14-13(15(21)18-16(14)22)11-6-1-2-7-12(11)19(23)24/h1-8,20H,(H2,17,18,21,22)
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SmithKline Beecham Pharmaceuticals



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 10 uM ATP/ [gamma-33P] ATP. Aft...

Bioorg Med Chem Lett 11: 635-9 (2001)


Article DOI: 10.1016/s0960-894x(00)00721-6
BindingDB Entry DOI: 10.7270/Q2QV3JRC
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 alpha


(Homo sapiens (Human))		BDBM8228
PNG
(3-[(3-chlorophenyl)amino]-4-(3-methoxyphenyl)-2,5-...)
Show SMILES COc1cccc(c1)C1=C(Nc2cccc(Cl)c2)C(=O)NC1=O |c:9|
Show InChI InChI=1S/C17H13ClN2O3/c1-23-13-7-2-4-10(8-13)14-15(17(22)20-16(14)21)19-12-6-3-5-11(18)9-12/h2-9H,1H3,(H2,19,20,21,22)
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SmithKline Beecham Pharmaceuticals



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 10 uM ATP/ [gamma-33P] ATP. Aft...

Bioorg Med Chem Lett 11: 635-9 (2001)


Article DOI: 10.1016/s0960-894x(00)00721-6
BindingDB Entry DOI: 10.7270/Q2QV3JRC
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 alpha


(Homo sapiens (Human))		BDBM8234
PNG
(3-[(3-hydroxyphenyl)amino]-4-(2-methoxyphenyl)-2,5...)
Show SMILES COc1ccccc1C1=C(Nc2cccc(O)c2)C(=O)NC1=O |c:9|
Show InChI InChI=1S/C17H14N2O4/c1-23-13-8-3-2-7-12(13)14-15(17(22)19-16(14)21)18-10-5-4-6-11(20)9-10/h2-9,20H,1H3,(H2,18,19,21,22)
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SmithKline Beecham Pharmaceuticals



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 10 uM ATP/ [gamma-33P] ATP. Aft...

Bioorg Med Chem Lett 11: 635-9 (2001)


Article DOI: 10.1016/s0960-894x(00)00721-6
BindingDB Entry DOI: 10.7270/Q2QV3JRC
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 alpha


(Homo sapiens (Human))		BDBM8259
PNG
(3-[(2,5-dioxo-4-phenyl-2,5-dihydro-1H-pyrrol-3-yl)...)
Show SMILES OC(=O)c1cccc(NC2=C(C(=O)NC2=O)c2ccccc2)c1 |t:9|
Show InChI InChI=1S/C17H12N2O4/c20-15-13(10-5-2-1-3-6-10)14(16(21)19-15)18-12-8-4-7-11(9-12)17(22)23/h1-9H,(H,22,23)(H2,18,19,20,21)
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SmithKline Beecham Pharmaceuticals



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 10 uM ATP/ [gamma-33P] ATP. Aft...

Bioorg Med Chem Lett 11: 635-9 (2001)


Article DOI: 10.1016/s0960-894x(00)00721-6
BindingDB Entry DOI: 10.7270/Q2QV3JRC
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 alpha


(Homo sapiens (Human))		BDBM8224
PNG
(3-[(3-chlorophenyl)amino]-4-phenyl-2,5-dihydro-1H-...)
Show SMILES Clc1cccc(NC2=C(C(=O)NC2=O)c2ccccc2)c1 |t:7|
Show InChI InChI=1S/C16H11ClN2O2/c17-11-7-4-8-12(9-11)18-14-13(15(20)19-16(14)21)10-5-2-1-3-6-10/h1-9H,(H2,18,19,20,21)
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n/an/a 301n/an/an/an/a7.022



SmithKline Beecham Pharmaceuticals



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 10 uM ATP/ [gamma-33P] ATP. Aft...

Bioorg Med Chem Lett 11: 635-9 (2001)


Article DOI: 10.1016/s0960-894x(00)00721-6
BindingDB Entry DOI: 10.7270/Q2QV3JRC
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 alpha


(Homo sapiens (Human))		BDBM8242
PNG
(3-(4-chlorophenyl)-4-[(4-hydroxyphenyl)amino]-2,5-...)
Show SMILES Oc1ccc(NC2=C(C(=O)NC2=O)c2ccc(Cl)cc2)cc1 |t:6|
Show InChI InChI=1S/C16H11ClN2O3/c17-10-3-1-9(2-4-10)13-14(16(22)19-15(13)21)18-11-5-7-12(20)8-6-11/h1-8,20H,(H2,18,19,21,22)
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SmithKline Beecham Pharmaceuticals



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 10 uM ATP/ [gamma-33P] ATP. Aft...

Bioorg Med Chem Lett 11: 635-9 (2001)


Article DOI: 10.1016/s0960-894x(00)00721-6
BindingDB Entry DOI: 10.7270/Q2QV3JRC
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 alpha


(Homo sapiens (Human))		BDBM8233
PNG
(3-(2-chlorophenyl)-4-[(3-hydroxyphenyl)amino]-2,5-...)
Show SMILES Oc1cccc(NC2=C(C(=O)NC2=O)c2ccccc2Cl)c1 |t:7|
Show InChI InChI=1S/C16H11ClN2O3/c17-12-7-2-1-6-11(12)13-14(16(22)19-15(13)21)18-9-4-3-5-10(20)8-9/h1-8,20H,(H2,18,19,21,22)
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SmithKline Beecham Pharmaceuticals



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 10 uM ATP/ [gamma-33P] ATP. Aft...

Bioorg Med Chem Lett 11: 635-9 (2001)


Article DOI: 10.1016/s0960-894x(00)00721-6
BindingDB Entry DOI: 10.7270/Q2QV3JRC
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 alpha


(Homo sapiens (Human))		BDBM8223
PNG
(3-(4-methoxyphenyl)-4-(phenylamino)-2,5-dihydro-1H...)
Show SMILES COc1ccc(cc1)C1=C(Nc2ccccc2)C(=O)NC1=O |c:9|
Show InChI InChI=1S/C17H14N2O3/c1-22-13-9-7-11(8-10-13)14-15(17(21)19-16(14)20)18-12-5-3-2-4-6-12/h2-10H,1H3,(H2,18,19,20,21)
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SmithKline Beecham Pharmaceuticals



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 10 uM ATP/ [gamma-33P] ATP. Aft...

Bioorg Med Chem Lett 11: 635-9 (2001)


Article DOI: 10.1016/s0960-894x(00)00721-6
BindingDB Entry DOI: 10.7270/Q2QV3JRC
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 alpha


(Homo sapiens (Human))		BDBM8281
PNG
(3-{[4-(methylsulfanyl)phenyl]amino}-4-(4-nitrophen...)
Show SMILES CSc1ccc(NC2=C(C(=O)NC2=O)c2ccc(cc2)N(=O)=O)cc1 |t:7|
Show InChI InChI=1S/C17H13N3O4S/c1-25-13-8-4-11(5-9-13)18-15-14(16(21)19-17(15)22)10-2-6-12(7-3-10)20(23)24/h2-9H,1H3,(H2,18,19,21,22)
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SmithKline Beecham Pharmaceuticals



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 10 uM ATP/ [gamma-33P] ATP. Aft...

Bioorg Med Chem Lett 11: 635-9 (2001)


Article DOI: 10.1016/s0960-894x(00)00721-6
BindingDB Entry DOI: 10.7270/Q2QV3JRC
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 alpha


(Homo sapiens (Human))		BDBM8273
PNG
(3-{[4-(methylsulfanyl)phenyl]amino}-4-phenyl-2,5-d...)
Show SMILES CSc1ccc(NC2=C(C(=O)NC2=O)c2ccccc2)cc1 |t:7|
Show InChI InChI=1S/C17H14N2O2S/c1-22-13-9-7-12(8-10-13)18-15-14(16(20)19-17(15)21)11-5-3-2-4-6-11/h2-10H,1H3,(H2,18,19,20,21)
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SmithKline Beecham Pharmaceuticals



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 10 uM ATP/ [gamma-33P] ATP. Aft...

Bioorg Med Chem Lett 11: 635-9 (2001)


Article DOI: 10.1016/s0960-894x(00)00721-6
BindingDB Entry DOI: 10.7270/Q2QV3JRC
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 alpha


(Homo sapiens (Human))		BDBM8239
PNG
(3-(4-chlorophenyl)-4-[(3-hydroxyphenyl)amino]-2,5-...)
Show SMILES Oc1cccc(NC2=C(C(=O)NC2=O)c2ccc(Cl)cc2)c1 |t:7|
Show InChI InChI=1S/C16H11ClN2O3/c17-10-6-4-9(5-7-10)13-14(16(22)19-15(13)21)18-11-2-1-3-12(20)8-11/h1-8,20H,(H2,18,19,21,22)
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SmithKline Beecham Pharmaceuticals



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 10 uM ATP/ [gamma-33P] ATP. Aft...

Bioorg Med Chem Lett 11: 635-9 (2001)


Article DOI: 10.1016/s0960-894x(00)00721-6
BindingDB Entry DOI: 10.7270/Q2QV3JRC
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 alpha


(Homo sapiens (Human))		BDBM8230
PNG
(3-(4-chlorophenyl)-4-[(3-chlorophenyl)amino]-2,5-d...)
Show SMILES Clc1ccc(cc1)C1=C(Nc2cccc(Cl)c2)C(=O)NC1=O |c:8|
Show InChI InChI=1S/C16H10Cl2N2O2/c17-10-6-4-9(5-7-10)13-14(16(22)20-15(13)21)19-12-3-1-2-11(18)8-12/h1-8H,(H2,19,20,21,22)
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SmithKline Beecham Pharmaceuticals



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 10 uM ATP/ [gamma-33P] ATP. Aft...

Bioorg Med Chem Lett 11: 635-9 (2001)


Article DOI: 10.1016/s0960-894x(00)00721-6
BindingDB Entry DOI: 10.7270/Q2QV3JRC
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 alpha


(Homo sapiens (Human))		BDBM8237
PNG
(3-[(3-hydroxyphenyl)amino]-4-(3-methoxyphenyl)-2,5...)
Show SMILES COc1cccc(c1)C1=C(Nc2cccc(O)c2)C(=O)NC1=O |c:9|
Show InChI InChI=1S/C17H14N2O4/c1-23-13-7-2-4-10(8-13)14-15(17(22)19-16(14)21)18-11-5-3-6-12(20)9-11/h2-9,20H,1H3,(H2,18,19,21,22)
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SmithKline Beecham Pharmaceuticals



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 10 uM ATP/ [gamma-33P] ATP. Aft...

Bioorg Med Chem Lett 11: 635-9 (2001)


Article DOI: 10.1016/s0960-894x(00)00721-6
BindingDB Entry DOI: 10.7270/Q2QV3JRC
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 alpha


(Homo sapiens (Human))		BDBM8240
PNG
(3-[(3-hydroxyphenyl)amino]-4-(4-methoxyphenyl)-2,5...)
Show SMILES COc1ccc(cc1)C1=C(Nc2cccc(O)c2)C(=O)NC1=O |c:9|
Show InChI InChI=1S/C17H14N2O4/c1-23-13-7-5-10(6-8-13)14-15(17(22)19-16(14)21)18-11-3-2-4-12(20)9-11/h2-9,20H,1H3,(H2,18,19,21,22)
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n/an/a 481n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 10 uM ATP/ [gamma-33P] ATP. Aft...

Bioorg Med Chem Lett 11: 635-9 (2001)


Article DOI: 10.1016/s0960-894x(00)00721-6
BindingDB Entry DOI: 10.7270/Q2QV3JRC
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 alpha


(Homo sapiens (Human))		BDBM8222
PNG
(3-(4-chlorophenyl)-4-(phenylamino)-2,5-dihydro-1H-...)
Show SMILES Clc1ccc(cc1)C1=C(Nc2ccccc2)C(=O)NC1=O |c:8|
Show InChI InChI=1S/C16H11ClN2O2/c17-11-8-6-10(7-9-11)13-14(16(21)19-15(13)20)18-12-4-2-1-3-5-12/h1-9H,(H2,18,19,20,21)
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n/an/a 514n/an/an/an/a7.022



SmithKline Beecham Pharmaceuticals



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 10 uM ATP/ [gamma-33P] ATP. Aft...

Bioorg Med Chem Lett 11: 635-9 (2001)


Article DOI: 10.1016/s0960-894x(00)00721-6
BindingDB Entry DOI: 10.7270/Q2QV3JRC
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 alpha


(Homo sapiens (Human))		BDBM8279
PNG
(3-(4-chlorophenyl)-4-{[4-(methylsulfanyl)phenyl]am...)
Show SMILES CSc1ccc(NC2=C(C(=O)NC2=O)c2ccc(Cl)cc2)cc1 |t:7|
Show InChI InChI=1S/C17H13ClN2O2S/c1-23-13-8-6-12(7-9-13)19-15-14(16(21)20-17(15)22)10-2-4-11(18)5-3-10/h2-9H,1H3,(H2,19,20,21,22)
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n/an/a 529n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 10 uM ATP/ [gamma-33P] ATP. Aft...

Bioorg Med Chem Lett 11: 635-9 (2001)


Article DOI: 10.1016/s0960-894x(00)00721-6
BindingDB Entry DOI: 10.7270/Q2QV3JRC
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 alpha


(Homo sapiens (Human))		BDBM8218
PNG
(3-phenyl-4-(phenylamino)-2,5-dihydro-1H-pyrrole-2,...)
Show SMILES O=C1NC(=O)C(=C1Nc1ccccc1)c1ccccc1 |c:5|
Show InChI InChI=1S/C16H12N2O2/c19-15-13(11-7-3-1-4-8-11)14(16(20)18-15)17-12-9-5-2-6-10-12/h1-10H,(H2,17,18,19,20)
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n/an/a 529n/an/an/an/a7.022



SmithKline Beecham Pharmaceuticals



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 10 uM ATP/ [gamma-33P] ATP. Aft...

Bioorg Med Chem Lett 11: 635-9 (2001)


Article DOI: 10.1016/s0960-894x(00)00721-6
BindingDB Entry DOI: 10.7270/Q2QV3JRC
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 alpha


(Homo sapiens (Human))		BDBM8276
PNG
(3-(3-chlorophenyl)-4-{[4-(methylsulfanyl)phenyl]am...)
Show SMILES CSc1ccc(NC2=C(C(=O)NC2=O)c2cccc(Cl)c2)cc1 |t:7|
Show InChI InChI=1S/C17H13ClN2O2S/c1-23-13-7-5-12(6-8-13)19-15-14(16(21)20-17(15)22)10-3-2-4-11(18)9-10/h2-9H,1H3,(H2,19,20,21,22)
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n/an/a 532n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 10 uM ATP/ [gamma-33P] ATP. Aft...

Bioorg Med Chem Lett 11: 635-9 (2001)


Article DOI: 10.1016/s0960-894x(00)00721-6
BindingDB Entry DOI: 10.7270/Q2QV3JRC
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 alpha


(Homo sapiens (Human))		BDBM8232
PNG
(3-[(3-hydroxyphenyl)amino]-4-phenyl-2,5-dihydro-1H...)
Show SMILES Oc1cccc(NC2=C(C(=O)NC2=O)c2ccccc2)c1 |t:7|
Show InChI InChI=1S/C16H12N2O3/c19-12-8-4-7-11(9-12)17-14-13(15(20)18-16(14)21)10-5-2-1-3-6-10/h1-9,19H,(H2,17,18,20,21)
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n/an/a 704n/an/an/an/a7.022



SmithKline Beecham Pharmaceuticals



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 10 uM ATP/ [gamma-33P] ATP. Aft...

Bioorg Med Chem Lett 11: 635-9 (2001)


Article DOI: 10.1016/s0960-894x(00)00721-6
BindingDB Entry DOI: 10.7270/Q2QV3JRC
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 alpha


(Homo sapiens (Human))		BDBM8236
PNG
(3-(3-chlorophenyl)-4-[(3-hydroxyphenyl)amino]-2,5-...)
Show SMILES Oc1cccc(NC2=C(C(=O)NC2=O)c2cccc(Cl)c2)c1 |t:7|
Show InChI InChI=1S/C16H11ClN2O3/c17-10-4-1-3-9(7-10)13-14(16(22)19-15(13)21)18-11-5-2-6-12(20)8-11/h1-8,20H,(H2,18,19,21,22)
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n/an/a 1.48E+3n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 10 uM ATP/ [gamma-33P] ATP. Aft...

Bioorg Med Chem Lett 11: 635-9 (2001)


Article DOI: 10.1016/s0960-894x(00)00721-6
BindingDB Entry DOI: 10.7270/Q2QV3JRC
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%