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PubMed code 11378353

Compile data set for download or QSAR
Found 14 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Peptide deformylase


(Staphylococcus aureus (strain Mu50 / ATCC 700699))		BDBM50099848
PNG
(CHEMBL30051 | N-Hydroxy-2-naphthalen-1-yl-2-(3-tri...)
Show SMILES ONC(=O)C(NCc1cccc(c1)C(F)(F)F)c1cccc2ccccc12
Show InChI InChI=1S/C20H17F3N2O2/c21-20(22,23)15-8-3-5-13(11-15)12-24-18(19(26)25-27)17-10-4-7-14-6-1-2-9-16(14)17/h1-11,18,24,27H,12H2,(H,25,26)
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n/an/a 46n/an/an/an/an/an/a



Pharmacia

Curated by ChEMBL


Assay Description
Inhibition of Peptidyl deformylase (PDF)

Bioorg Med Chem Lett 11: 1355-8 (2001)


BindingDB Entry DOI: 10.7270/Q2D50M7N
More data for this
Ligand-Target Pair
Peptide deformylase


(Staphylococcus aureus (strain Mu50 / ATCC 700699))		BDBM50099846
PNG
(CHEMBL29911 | N-Hydroxy-2-(3-methoxy-phenyl)-2-(3-...)
Show SMILES COc1cccc(c1)C(NCc1cccc(c1)C(F)(F)F)C(=O)NO
Show InChI InChI=1S/C17H17F3N2O3/c1-25-14-7-3-5-12(9-14)15(16(23)22-24)21-10-11-4-2-6-13(8-11)17(18,19)20/h2-9,15,21,24H,10H2,1H3,(H,22,23)
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n/an/a 59n/an/an/an/an/an/a



Pharmacia

Curated by ChEMBL


Assay Description
Inhibition of Peptidyl deformylase (PDF)

Bioorg Med Chem Lett 11: 1355-8 (2001)


BindingDB Entry DOI: 10.7270/Q2D50M7N
More data for this
Ligand-Target Pair
Peptide deformylase


(Staphylococcus aureus (strain Mu50 / ATCC 700699))		BDBM50099855
PNG
(2-(2-Chloro-4,5-dimethoxy-phenyl)-N-hydroxy-acetam...)
Show SMILES COc1cc(Cl)c(CC(=O)NO)cc1OC
Show InChI InChI=1S/C10H12ClNO4/c1-15-8-3-6(4-10(13)12-14)7(11)5-9(8)16-2/h3,5,14H,4H2,1-2H3,(H,12,13)
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n/an/a 200n/an/an/an/an/an/a



Pharmacia

Curated by ChEMBL


Assay Description
Inhibition of Peptidyl deformylase (PDF)

Bioorg Med Chem Lett 11: 1355-8 (2001)


BindingDB Entry DOI: 10.7270/Q2D50M7N
More data for this
Ligand-Target Pair
Peptide deformylase


(Staphylococcus aureus (strain Mu50 / ATCC 700699))		BDBM50099849
PNG
(2-(2-Fluoro-phenyl)-N-hydroxy-2-(3-trifluoromethyl...)
Show SMILES ONC(=O)C(NCc1cccc(c1)C(F)(F)F)c1ccccc1F
Show InChI InChI=1S/C16H14F4N2O2/c17-13-7-2-1-6-12(13)14(15(23)22-24)21-9-10-4-3-5-11(8-10)16(18,19)20/h1-8,14,21,24H,9H2,(H,22,23)
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n/an/a 460n/an/an/an/an/an/a



Pharmacia

Curated by ChEMBL


Assay Description
Inhibition of Peptidyl deformylase (PDF)

Bioorg Med Chem Lett 11: 1355-8 (2001)


BindingDB Entry DOI: 10.7270/Q2D50M7N
More data for this
Ligand-Target Pair
Peptide deformylase


(Staphylococcus aureus (strain Mu50 / ATCC 700699))		BDBM50099847
PNG
(2-(3,4-Difluoro-phenyl)-N-hydroxy-2-(3-trifluorome...)
Show SMILES ONC(=O)C(NCc1cccc(c1)C(F)(F)F)c1ccc(F)c(F)c1
Show InChI InChI=1S/C16H13F5N2O2/c17-12-5-4-10(7-13(12)18)14(15(24)23-25)22-8-9-2-1-3-11(6-9)16(19,20)21/h1-7,14,22,25H,8H2,(H,23,24)
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n/an/a 690n/an/an/an/an/an/a



Pharmacia

Curated by ChEMBL


Assay Description
Inhibition of Peptidyl deformylase (PDF)

Bioorg Med Chem Lett 11: 1355-8 (2001)


BindingDB Entry DOI: 10.7270/Q2D50M7N
More data for this
Ligand-Target Pair
Peptide deformylase


(Staphylococcus aureus (strain Mu50 / ATCC 700699))		BDBM50099856
PNG
(CHEMBL29912 | N'-hydroxy-N-1-naphthyl-N-{2-[3-(tri...)
Show SMILES ONC(=O)N(CCc1cccc(c1)C(F)(F)F)c1cccc2ccccc12
Show InChI InChI=1S/C20H17F3N2O2/c21-20(22,23)16-8-3-5-14(13-16)11-12-25(19(26)24-27)18-10-4-7-15-6-1-2-9-17(15)18/h1-10,13,27H,11-12H2,(H,24,26)
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n/an/a 2.20E+3n/an/an/an/an/an/a



Pharmacia

Curated by ChEMBL


Assay Description
Inhibition of Peptidyl deformylase (PDF)

Bioorg Med Chem Lett 11: 1355-8 (2001)


BindingDB Entry DOI: 10.7270/Q2D50M7N
More data for this
Ligand-Target Pair
Peptide deformylase


(Staphylococcus aureus (strain Mu50 / ATCC 700699))		BDBM50099853
PNG
(CHEMBL26420 | Naphthalen-1-yl-(3-trifluoromethyl-b...)
Show SMILES NNC(=O)C(NCc1cccc(c1)C(F)(F)F)c1cccc2ccccc12
Show InChI InChI=1S/C20H18F3N3O/c21-20(22,23)15-8-3-5-13(11-15)12-25-18(19(27)26-24)17-10-4-7-14-6-1-2-9-16(14)17/h1-11,18,25H,12,24H2,(H,26,27)
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n/an/a 4.10E+3n/an/an/an/an/an/a



Pharmacia

Curated by ChEMBL


Assay Description
Inhibition of Peptidyl deformylase (PDF)

Bioorg Med Chem Lett 11: 1355-8 (2001)


BindingDB Entry DOI: 10.7270/Q2D50M7N
More data for this
Ligand-Target Pair
Peptide deformylase


(Staphylococcus aureus (strain Mu50 / ATCC 700699))		BDBM50099845
PNG
(2-Biphenyl-4-yl-N-hydroxy-acetamide | CHEMBL30068)
Show SMILES ONC(=O)Cc1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C14H13NO2/c16-14(15-17)10-11-6-8-13(9-7-11)12-4-2-1-3-5-12/h1-9,17H,10H2,(H,15,16)
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n/an/a>5.00E+4n/an/an/an/an/an/a



Pharmacia

Curated by ChEMBL


Assay Description
Inhibition of Peptidyl deformylase (PDF)

Bioorg Med Chem Lett 11: 1355-8 (2001)


BindingDB Entry DOI: 10.7270/Q2D50M7N
More data for this
Ligand-Target Pair
Peptide deformylase


(Staphylococcus aureus (strain Mu50 / ATCC 700699))		BDBM50099844
PNG
(2-Mercapto-N-naphthalen-1-yl-N-[2-(3-trifluorometh...)
Show SMILES FC(F)(F)c1cccc(CCN(C(=O)CS)c2cccc3ccccc23)c1
Show InChI InChI=1S/C21H18F3NOS/c22-21(23,24)17-8-3-5-15(13-17)11-12-25(20(26)14-27)19-10-4-7-16-6-1-2-9-18(16)19/h1-10,13,27H,11-12,14H2
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n/an/a>1.00E+5n/an/an/an/an/an/a



Pharmacia

Curated by ChEMBL


Assay Description
Inhibition of Peptidyl deformylase (PDF)

Bioorg Med Chem Lett 11: 1355-8 (2001)


BindingDB Entry DOI: 10.7270/Q2D50M7N
More data for this
Ligand-Target Pair
Peptide deformylase


(Staphylococcus aureus (strain Mu50 / ATCC 700699))		BDBM50099851
PNG
(CHEMBL27348 | N-1-naphthyl-N-{2-[3-(trifluoromethy...)
Show SMILES NNC(=O)N(CCc1cccc(c1)C(F)(F)F)c1cccc2ccccc12
Show InChI InChI=1S/C20H18F3N3O/c21-20(22,23)16-8-3-5-14(13-16)11-12-26(19(27)25-24)18-10-4-7-15-6-1-2-9-17(15)18/h1-10,13H,11-12,24H2,(H,25,27)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Pharmacia

Curated by ChEMBL


Assay Description
Inhibition of Peptidyl deformylase (PDF)

Bioorg Med Chem Lett 11: 1355-8 (2001)


BindingDB Entry DOI: 10.7270/Q2D50M7N
More data for this
Ligand-Target Pair
Peptide deformylase


(Staphylococcus aureus (strain Mu50 / ATCC 700699))		BDBM50099854
PNG
(2-Hydroxy-N-naphthalen-1-yl-N-[2-(3-trifluoromethy...)
Show SMILES OCC(=O)N(CCc1cccc(c1)C(F)(F)F)c1cccc2ccccc12
Show InChI InChI=1S/C21H18F3NO2/c22-21(23,24)17-8-3-5-15(13-17)11-12-25(20(27)14-26)19-10-4-7-16-6-1-2-9-18(16)19/h1-10,13,26H,11-12,14H2
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n/an/a>1.00E+5n/an/an/an/an/an/a



Pharmacia

Curated by ChEMBL


Assay Description
Inhibition of Peptidyl deformylase (PDF)

Bioorg Med Chem Lett 11: 1355-8 (2001)


BindingDB Entry DOI: 10.7270/Q2D50M7N
More data for this
Ligand-Target Pair
Peptide deformylase


(Staphylococcus aureus (strain Mu50 / ATCC 700699))		BDBM50099850
PNG
(2-Naphthalen-1-yl-2-(3-trifluoromethyl-benzylamino...)
Show SMILES NC(=O)C(NCc1cccc(c1)C(F)(F)F)c1cccc2ccccc12
Show InChI InChI=1S/C20H17F3N2O/c21-20(22,23)15-8-3-5-13(11-15)12-25-18(19(24)26)17-10-4-7-14-6-1-2-9-16(14)17/h1-11,18,25H,12H2,(H2,24,26)
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Pharmacia

Curated by ChEMBL


Assay Description
Inhibition of Peptidyl deformylase (PDF)

Bioorg Med Chem Lett 11: 1355-8 (2001)


BindingDB Entry DOI: 10.7270/Q2D50M7N
More data for this
Ligand-Target Pair
Peptide deformylase


(Staphylococcus aureus (strain Mu50 / ATCC 700699))		BDBM50099852
PNG
(CHEMBL29796 | Naphthalen-1-yl-(3-trifluoromethyl-b...)
Show SMILES OC(=O)C(NCc1cccc(c1)C(F)(F)F)c1cccc2ccccc12
Show InChI InChI=1S/C20H16F3NO2/c21-20(22,23)15-8-3-5-13(11-15)12-24-18(19(25)26)17-10-4-7-14-6-1-2-9-16(14)17/h1-11,18,24H,12H2,(H,25,26)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Pharmacia

Curated by ChEMBL


Assay Description
Inhibition of Peptidyl deformylase (PDF)

Bioorg Med Chem Lett 11: 1355-8 (2001)


BindingDB Entry DOI: 10.7270/Q2D50M7N
More data for this
Ligand-Target Pair
Peptide deformylase


(Staphylococcus aureus (strain Mu50 / ATCC 700699))		BDBM50099857
PNG
(ACETOHYDROXAMIC ACID (AHA) | AHA | Acethydroxamsae...)
Show SMILES CC(=O)NO
Show InChI InChI=1S/C2H5NO2/c1-2(4)3-5/h5H,1H3,(H,3,4)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Pharmacia

Curated by ChEMBL


Assay Description
Inhibition of Peptidyl deformylase (PDF)

Bioorg Med Chem Lett 11: 1355-8 (2001)


BindingDB Entry DOI: 10.7270/Q2D50M7N
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%