Affinity Data by PubMed id=11689087

PubMed code 11689087

Found 26 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Insulin-like growth factor-binding protein 4 (Homo sapiens (Human))	BDBM50106431 (1-(3,4-Dihydroxy-benzoyl)-6,7-dihydroxy-isoquinoli...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	PubMed	1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences, Inc. Curated by ChEMBL					Assay Description The compound was tested for binding affinity against Insulin-like growth factor binding protein 4				J Med Chem 44: 4001-10 (2001) BindingDB Entry DOI: 10.7270/Q2F18Z12
Neurocrine Biosciences, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Insulin-like growth factor-binding protein 2 (Homo sapiens (Human))	BDBM50106431 (1-(3,4-Dihydroxy-benzoyl)-6,7-dihydroxy-isoquinoli...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	PubMed	2.10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences, Inc. Curated by ChEMBL					Assay Description The compound was tested for binding affinity against insulin-like growth factor binding protein 2				J Med Chem 44: 4001-10 (2001) BindingDB Entry DOI: 10.7270/Q2F18Z12
Neurocrine Biosciences, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Insulin-like growth factor-binding protein 1 (Homo sapiens (Human))	BDBM50106431 (1-(3,4-Dihydroxy-benzoyl)-6,7-dihydroxy-isoquinoli...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	PubMed	5.10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences, Inc. Curated by ChEMBL					Assay Description The compound was tested for binding affinity against insulin-like growth factor binding protein 1				J Med Chem 44: 4001-10 (2001) BindingDB Entry DOI: 10.7270/Q2F18Z12
Neurocrine Biosciences, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Insulin-like growth factor-binding protein 5 (Homo sapiens (Human))	BDBM50106431 (1-(3,4-Dihydroxy-benzoyl)-6,7-dihydroxy-isoquinoli...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	PubMed	5.20	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences, Inc. Curated by ChEMBL					Assay Description The compound was tested for binding affinity against Insulin-like growth factor binding protein 5				J Med Chem 44: 4001-10 (2001) BindingDB Entry DOI: 10.7270/Q2F18Z12
Neurocrine Biosciences, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Insulin-like growth factor-binding protein 3 (Homo sapiens (Human))	BDBM50106431 (1-(3,4-Dihydroxy-benzoyl)-6,7-dihydroxy-isoquinoli...) Show SMILES Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	PubMed	5.60	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences, Inc. Curated by ChEMBL					Assay Description Inhibitory activity against Insulin-like growth factor binding protein 3				J Med Chem 44: 4001-10 (2001) BindingDB Entry DOI: 10.7270/Q2F18Z12
Neurocrine Biosciences, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Insulin-like growth factor-binding protein 4 (Homo sapiens (Human))	BDBM50106432 ((3,4-Dihydroxy-phenyl)-(3,6,7-trihydroxy-isoquinol...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	6.20	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences, Inc. Curated by ChEMBL					Assay Description The compound was tested for binding affinity against Insulin-like growth factor binding protein 4				J Med Chem 44: 4001-10 (2001) BindingDB Entry DOI: 10.7270/Q2F18Z12
Neurocrine Biosciences, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Insulin-like growth factor-binding protein 3 (Homo sapiens (Human))	BDBM50106443 (1-(3,4-Dihydroxy-benzyl)-6,7-dihydroxy-isoquinolin...) Show SMILES Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	7.5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences, Inc. Curated by ChEMBL					Assay Description Inhibitory activity against Insulin-like growth factor binding protein 3				J Med Chem 44: 4001-10 (2001) BindingDB Entry DOI: 10.7270/Q2F18Z12
Neurocrine Biosciences, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Insulin-like growth factor-binding protein 3 (Homo sapiens (Human))	BDBM50106446 (6,7-Dihydroxy-1-(naphthalene-2-carbonyl)-isoquinol...) Show SMILES Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	13	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences, Inc. Curated by ChEMBL					Assay Description Inhibitory activity against Insulin-like growth factor binding protein 3				J Med Chem 44: 4001-10 (2001) BindingDB Entry DOI: 10.7270/Q2F18Z12
Neurocrine Biosciences, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Insulin-like growth factor-binding protein 2 (Homo sapiens (Human))	BDBM50106432 ((3,4-Dihydroxy-phenyl)-(3,6,7-trihydroxy-isoquinol...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	17	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences, Inc. Curated by ChEMBL					Assay Description The compound was tested for binding affinity against insulin-like growth factor binding protein 2				J Med Chem 44: 4001-10 (2001) BindingDB Entry DOI: 10.7270/Q2F18Z12
Neurocrine Biosciences, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Insulin-like growth factor-binding protein 5 (Homo sapiens (Human))	BDBM50106432 ((3,4-Dihydroxy-phenyl)-(3,6,7-trihydroxy-isoquinol...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	21	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences, Inc. Curated by ChEMBL					Assay Description The compound was tested for binding affinity against Insulin-like growth factor binding protein 5				J Med Chem 44: 4001-10 (2001) BindingDB Entry DOI: 10.7270/Q2F18Z12
Neurocrine Biosciences, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Insulin-like growth factor-binding protein 6 (Homo sapiens (Human))	BDBM50106431 (1-(3,4-Dihydroxy-benzoyl)-6,7-dihydroxy-isoquinoli...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	PubMed	24	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences, Inc. Curated by ChEMBL					Assay Description The compound was tested for binding affinity against Insulin-like growth factor binding protein 6				J Med Chem 44: 4001-10 (2001) BindingDB Entry DOI: 10.7270/Q2F18Z12
Neurocrine Biosciences, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Insulin-like growth factor-binding protein 3 (Homo sapiens (Human))	BDBM50106439 (6,7-Dihydroxy-1-(naphthalene-1-carbonyl)-isoquinol...) Show SMILES Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	27	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences, Inc. Curated by ChEMBL					Assay Description Inhibitory activity against Insulin-like growth factor binding protein 3				J Med Chem 44: 4001-10 (2001) BindingDB Entry DOI: 10.7270/Q2F18Z12
Neurocrine Biosciences, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Insulin-like growth factor-binding protein 3 (Homo sapiens (Human))	BDBM50106432 ((3,4-Dihydroxy-phenyl)-(3,6,7-trihydroxy-isoquinol...) Show SMILES Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	28	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences, Inc. Curated by ChEMBL					Assay Description Inhibitory activity against Insulin-like growth factor binding protein 3				J Med Chem 44: 4001-10 (2001) BindingDB Entry DOI: 10.7270/Q2F18Z12
Neurocrine Biosciences, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Insulin-like growth factor-binding protein 3 (Homo sapiens (Human))	BDBM50106441 (1-(3,4-Dihydroxy-benzyl)-isoquinoline-3,6,7-triol ...) Show SMILES Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	29	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences, Inc. Curated by ChEMBL					Assay Description Inhibitory activity against Insulin-like growth factor binding protein 3				J Med Chem 44: 4001-10 (2001) BindingDB Entry DOI: 10.7270/Q2F18Z12
Neurocrine Biosciences, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Insulin-like growth factor-binding protein 1 (Homo sapiens (Human))	BDBM50106432 ((3,4-Dihydroxy-phenyl)-(3,6,7-trihydroxy-isoquinol...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	34	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences, Inc. Curated by ChEMBL					Assay Description The compound was tested for binding affinity against insulin-like growth factor binding protein 1				J Med Chem 44: 4001-10 (2001) BindingDB Entry DOI: 10.7270/Q2F18Z12
Neurocrine Biosciences, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Insulin-like growth factor-binding protein 3 (Homo sapiens (Human))	BDBM50106433 (1-(2,4-Dichloro-benzoyl)-6,7-dihydroxy-isoquinolin...) Show SMILES Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	44	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences, Inc. Curated by ChEMBL					Assay Description Inhibitory activity against Insulin-like growth factor binding protein 3				J Med Chem 44: 4001-10 (2001) BindingDB Entry DOI: 10.7270/Q2F18Z12
Neurocrine Biosciences, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Insulin-like growth factor-binding protein 3 (Homo sapiens (Human))	BDBM50106436 ((6,7-Dihydroxy-isoquinolin-1-yl)-(3,4-dihydroxy-ph...) Show SMILES Oc1ccc(cc1O)C(=O)c1nccc2cc(O)c(O)cc12 Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	58	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences, Inc. Curated by ChEMBL					Assay Description Inhibitory activity against Insulin-like growth factor binding protein 3				J Med Chem 44: 4001-10 (2001) BindingDB Entry DOI: 10.7270/Q2F18Z12
Neurocrine Biosciences, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Insulin-like growth factor-binding protein 3 (Homo sapiens (Human))	BDBM50106437 (5-Bromo-1-(3,4-dihydroxy-benzoyl)-6-hydroxy-7-meth...) Show SMILES Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	70	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences, Inc. Curated by ChEMBL					Assay Description Inhibitory activity against Insulin-like growth factor binding protein 3				J Med Chem 44: 4001-10 (2001) BindingDB Entry DOI: 10.7270/Q2F18Z12
Neurocrine Biosciences, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Insulin-like growth factor-binding protein 3 (Homo sapiens (Human))	BDBM50106438 (1-(Benzo[1,3]dioxole-5-carbonyl)-6,7-dihydroxy-iso...) Show SMILES Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	70	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences, Inc. Curated by ChEMBL					Assay Description Inhibitory activity against Insulin-like growth factor binding protein 3				J Med Chem 44: 4001-10 (2001) BindingDB Entry DOI: 10.7270/Q2F18Z12
Neurocrine Biosciences, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Insulin-like growth factor-binding protein 6 (Homo sapiens (Human))	BDBM50106432 ((3,4-Dihydroxy-phenyl)-(3,6,7-trihydroxy-isoquinol...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	85	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences, Inc. Curated by ChEMBL					Assay Description The compound was tested for binding affinity against Insulin-like growth factor binding protein 6				J Med Chem 44: 4001-10 (2001) BindingDB Entry DOI: 10.7270/Q2F18Z12
Neurocrine Biosciences, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Insulin-like growth factor-binding protein 3 (Homo sapiens (Human))	BDBM50106440 (8-Bromo-1-(3,4-dihydroxy-benzoyl)-7-hydroxy-6-meth...) Show SMILES Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	140	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences, Inc. Curated by ChEMBL					Assay Description Inhibitory activity against Insulin-like growth factor binding protein 3				J Med Chem 44: 4001-10 (2001) BindingDB Entry DOI: 10.7270/Q2F18Z12
Neurocrine Biosciences, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Insulin-like growth factor-binding protein 3 (Homo sapiens (Human))	BDBM50106435 (7-Hydroxy-1-(3-hydroxy-4-methoxy-benzoyl)-6-methox...) Show SMILES Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	320	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences, Inc. Curated by ChEMBL					Assay Description Inhibitory activity against Insulin-like growth factor binding protein 3				J Med Chem 44: 4001-10 (2001) BindingDB Entry DOI: 10.7270/Q2F18Z12
Neurocrine Biosciences, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Insulin-like growth factor-binding protein 3 (Homo sapiens (Human))	BDBM50106444 (1-(3-Hydroxy-4-methoxy-benzoyl)-6,7-dimethoxy-isoq...) Show SMILES Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences, Inc. Curated by ChEMBL					Assay Description Inhibitory activity against Insulin-like growth factor binding protein 3				J Med Chem 44: 4001-10 (2001) BindingDB Entry DOI: 10.7270/Q2F18Z12
Neurocrine Biosciences, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Insulin-like growth factor-binding protein 3 (Homo sapiens (Human))	BDBM50106434 (1-(3,4-Dimethoxy-benzoyl)-6,7-dimethoxy-isoquinoli...) Show SMILES Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences, Inc. Curated by ChEMBL					Assay Description Inhibitory activity against Insulin-like growth factor binding protein 3				J Med Chem 44: 4001-10 (2001) BindingDB Entry DOI: 10.7270/Q2F18Z12
Neurocrine Biosciences, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Insulin-like growth factor-binding protein 3 (Homo sapiens (Human))	BDBM50106442 (1-(3,4-Dihydroxy-benzoyl)-6,7-dimethoxy-isoquinoli...) Show SMILES Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences, Inc. Curated by ChEMBL					Assay Description Inhibitory activity against Insulin-like growth factor binding protein 3				J Med Chem 44: 4001-10 (2001) BindingDB Entry DOI: 10.7270/Q2F18Z12
Neurocrine Biosciences, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Insulin-like growth factor-binding protein 3 (Homo sapiens (Human))	BDBM50106445 ((3,4-Dimethoxy-phenyl)-(3-hydroxy-6,7-dimethoxy-is...) Show SMILES Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences, Inc. Curated by ChEMBL					Assay Description Inhibitory activity against Insulin-like growth factor binding protein 3				J Med Chem 44: 4001-10 (2001) BindingDB Entry DOI: 10.7270/Q2F18Z12
Neurocrine Biosciences, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair

* indicates data uncertainty>20%