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PubMed code 12036372

Compile data set for download or QSAR
Found 143 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Protein kinase C epsilon type


(Homo sapiens (Human))
BDBM3152
PNG
(2-{[2,6-dihydroxy-4-({[(3R,4R)-4-[(4-hydroxybenzen...)
Show SMILES OC(=O)c1cccc(O)c1C(=O)c1c(O)cc(cc1O)C(=O)O[C@@H]1CNC[C@H]1NC(=O)c1ccc(O)cc1 |r|
Show InChI InChI=1S/C26H22N2O10/c29-14-6-4-12(5-7-14)24(34)28-16-10-27-11-20(16)38-26(37)13-8-18(31)22(19(32)9-13)23(33)21-15(25(35)36)2-1-3-17(21)30/h1-9,16,20,27,29-32H,10-11H2,(H,28,34)(H,35,36)/t16-,20-/m1/s1
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n/an/a 10n/an/an/an/an/an/a



Sphinx Laboratories



Assay Description
PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.


J Med Chem 45: 2624-43 (2002)


Article DOI: 10.1021/jm020018f
BindingDB Entry DOI: 10.7270/Q2BG2M50
More data for this
Ligand-Target Pair
cAMP-dependent protein kinase catalytic subunit alpha


(Bos taurus (bovine))
BDBM3153
PNG
(2-{[2,6-dihydroxy-4-({[(1R,2R)-2-[(4-hydroxybenzen...)
Show SMILES OC(=O)c1cccc(O)c1C(=O)c1c(O)cc(cc1O)C(=O)O[C@@H]1CCC[C@H]1NC(=O)c1ccc(O)cc1 |r|
Show InChI InChI=1S/C27H23NO10/c29-15-9-7-13(8-10-15)25(34)28-17-4-2-6-21(17)38-27(37)14-11-19(31)23(20(32)12-14)24(33)22-16(26(35)36)3-1-5-18(22)30/h1,3,5,7-12,17,21,29-32H,2,4,6H2,(H,28,34)(H,35,36)/t17-,21-/m1/s1
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n/an/a 20n/an/an/an/an/an/a



Sphinx Laboratories



Assay Description
The activity of PKA, activated by cAMP, is measured by its ability to transfer phosphate from [gamma-32P]ATP to histone.


J Med Chem 45: 2624-43 (2002)


Article DOI: 10.1021/jm020018f
BindingDB Entry DOI: 10.7270/Q2BG2M50
More data for this
Ligand-Target Pair
Protein kinase C alpha type


(Homo sapiens (Human))
BDBM3152
PNG
(2-{[2,6-dihydroxy-4-({[(3R,4R)-4-[(4-hydroxybenzen...)
Show SMILES OC(=O)c1cccc(O)c1C(=O)c1c(O)cc(cc1O)C(=O)O[C@@H]1CNC[C@H]1NC(=O)c1ccc(O)cc1 |r|
Show InChI InChI=1S/C26H22N2O10/c29-14-6-4-12(5-7-14)24(34)28-16-10-27-11-20(16)38-26(37)13-8-18(31)22(19(32)9-13)23(33)21-15(25(35)36)2-1-3-17(21)30/h1-9,16,20,27,29-32H,10-11H2,(H,28,34)(H,35,36)/t16-,20-/m1/s1
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n/an/a 22n/an/an/an/an/an/a



Sphinx Laboratories



Assay Description
PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.


J Med Chem 45: 2624-43 (2002)


Article DOI: 10.1021/jm020018f
BindingDB Entry DOI: 10.7270/Q2BG2M50
More data for this
Ligand-Target Pair
Protein kinase C beta type


(Homo sapiens (Human))
BDBM3149
PNG
(2-{[2,6-dihydroxy-4-({[(3R,4R)-3-[(4-hydroxybenzen...)
Show SMILES OC(=O)c1cccc(O)c1C(=O)c1c(O)cc(cc1O)C(=O)O[C@@H]1CCCNC[C@H]1NC(=O)c1ccc(O)cc1 |r|
Show InChI InChI=1S/C28H26N2O10/c31-16-8-6-14(7-9-16)26(36)30-18-13-29-10-2-5-22(18)40-28(39)15-11-20(33)24(21(34)12-15)25(35)23-17(27(37)38)3-1-4-19(23)32/h1,3-4,6-9,11-12,18,22,29,31-34H,2,5,10,13H2,(H,30,36)(H,37,38)/t18-,22-/m1/s1
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n/an/a 30n/an/an/an/an/an/a



Sphinx Laboratories



Assay Description
PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.


J Med Chem 45: 2624-43 (2002)


Article DOI: 10.1021/jm020018f
BindingDB Entry DOI: 10.7270/Q2BG2M50
More data for this
Ligand-Target Pair
Protein kinase C beta type


(Homo sapiens (Human))
BDBM3152
PNG
(2-{[2,6-dihydroxy-4-({[(3R,4R)-4-[(4-hydroxybenzen...)
Show SMILES OC(=O)c1cccc(O)c1C(=O)c1c(O)cc(cc1O)C(=O)O[C@@H]1CNC[C@H]1NC(=O)c1ccc(O)cc1 |r|
Show InChI InChI=1S/C26H22N2O10/c29-14-6-4-12(5-7-14)24(34)28-16-10-27-11-20(16)38-26(37)13-8-18(31)22(19(32)9-13)23(33)21-15(25(35)36)2-1-3-17(21)30/h1-9,16,20,27,29-32H,10-11H2,(H,28,34)(H,35,36)/t16-,20-/m1/s1
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n/an/a 33n/an/an/an/an/an/a



Sphinx Laboratories



Assay Description
PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.


J Med Chem 45: 2624-43 (2002)


Article DOI: 10.1021/jm020018f
BindingDB Entry DOI: 10.7270/Q2BG2M50
More data for this
Ligand-Target Pair
Protein kinase C epsilon type


(Homo sapiens (Human))
BDBM3149
PNG
(2-{[2,6-dihydroxy-4-({[(3R,4R)-3-[(4-hydroxybenzen...)
Show SMILES OC(=O)c1cccc(O)c1C(=O)c1c(O)cc(cc1O)C(=O)O[C@@H]1CCCNC[C@H]1NC(=O)c1ccc(O)cc1 |r|
Show InChI InChI=1S/C28H26N2O10/c31-16-8-6-14(7-9-16)26(36)30-18-13-29-10-2-5-22(18)40-28(39)15-11-20(33)24(21(34)12-15)25(35)23-17(27(37)38)3-1-4-19(23)32/h1,3-4,6-9,11-12,18,22,29,31-34H,2,5,10,13H2,(H,30,36)(H,37,38)/t18-,22-/m1/s1
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n/an/a 38n/an/an/an/an/an/a



Sphinx Laboratories



Assay Description
PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.


J Med Chem 45: 2624-43 (2002)


Article DOI: 10.1021/jm020018f
BindingDB Entry DOI: 10.7270/Q2BG2M50
More data for this
Ligand-Target Pair
Protein kinase C alpha type


(Homo sapiens (Human))
BDBM3153
PNG
(2-{[2,6-dihydroxy-4-({[(1R,2R)-2-[(4-hydroxybenzen...)
Show SMILES OC(=O)c1cccc(O)c1C(=O)c1c(O)cc(cc1O)C(=O)O[C@@H]1CCC[C@H]1NC(=O)c1ccc(O)cc1 |r|
Show InChI InChI=1S/C27H23NO10/c29-15-9-7-13(8-10-15)25(34)28-17-4-2-6-21(17)38-27(37)14-11-19(31)23(20(32)12-14)24(33)22-16(26(35)36)3-1-5-18(22)30/h1,3,5,7-12,17,21,29-32H,2,4,6H2,(H,28,34)(H,35,36)/t17-,21-/m1/s1
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n/an/a 40n/an/an/an/an/an/a



Sphinx Laboratories



Assay Description
PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.


J Med Chem 45: 2624-43 (2002)


Article DOI: 10.1021/jm020018f
BindingDB Entry DOI: 10.7270/Q2BG2M50
More data for this
Ligand-Target Pair
Protein kinase C beta type


(Homo sapiens (Human))
BDBM3153
PNG
(2-{[2,6-dihydroxy-4-({[(1R,2R)-2-[(4-hydroxybenzen...)
Show SMILES OC(=O)c1cccc(O)c1C(=O)c1c(O)cc(cc1O)C(=O)O[C@@H]1CCC[C@H]1NC(=O)c1ccc(O)cc1 |r|
Show InChI InChI=1S/C27H23NO10/c29-15-9-7-13(8-10-15)25(34)28-17-4-2-6-21(17)38-27(37)14-11-19(31)23(20(32)12-14)24(33)22-16(26(35)36)3-1-5-18(22)30/h1,3,5,7-12,17,21,29-32H,2,4,6H2,(H,28,34)(H,35,36)/t17-,21-/m1/s1
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Sphinx Laboratories



Assay Description
PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.


J Med Chem 45: 2624-43 (2002)


Article DOI: 10.1021/jm020018f
BindingDB Entry DOI: 10.7270/Q2BG2M50
More data for this
Ligand-Target Pair
cAMP-dependent protein kinase catalytic subunit alpha


(Bos taurus (bovine))
BDBM3230
PNG
((3R,4R)-4-[(4-hydroxybenzene)amido]pyrrolidin-3-yl...)
Show SMILES Oc1ccc(cc1)C(=O)N[C@@H]1CNC[C@H]1OC(=O)c1cc(O)c(C(=O)c2c(O)ccc3CCCCc23)c(O)c1 |r|
Show InChI InChI=1S/C29H28N2O8/c32-18-8-5-16(6-9-18)28(37)31-20-13-30-14-24(20)39-29(38)17-11-22(34)26(23(35)12-17)27(36)25-19-4-2-1-3-15(19)7-10-21(25)33/h5-12,20,24,30,32-35H,1-4,13-14H2,(H,31,37)/t20-,24-/m1/s1
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Sphinx Laboratories



Assay Description
The activity of PKA, activated by cAMP, is measured by its ability to transfer phosphate from [gamma-32P]ATP to histone.


J Med Chem 45: 2624-43 (2002)


Article DOI: 10.1021/jm020018f
BindingDB Entry DOI: 10.7270/Q2BG2M50
More data for this
Ligand-Target Pair
Protein kinase C epsilon type


(Homo sapiens (Human))
BDBM3153
PNG
(2-{[2,6-dihydroxy-4-({[(1R,2R)-2-[(4-hydroxybenzen...)
Show SMILES OC(=O)c1cccc(O)c1C(=O)c1c(O)cc(cc1O)C(=O)O[C@@H]1CCC[C@H]1NC(=O)c1ccc(O)cc1 |r|
Show InChI InChI=1S/C27H23NO10/c29-15-9-7-13(8-10-15)25(34)28-17-4-2-6-21(17)38-27(37)14-11-19(31)23(20(32)12-14)24(33)22-16(26(35)36)3-1-5-18(22)30/h1,3,5,7-12,17,21,29-32H,2,4,6H2,(H,28,34)(H,35,36)/t17-,21-/m1/s1
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Sphinx Laboratories



Assay Description
PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.


J Med Chem 45: 2624-43 (2002)


Article DOI: 10.1021/jm020018f
BindingDB Entry DOI: 10.7270/Q2BG2M50
More data for this
Ligand-Target Pair
Protein kinase C beta type


(Homo sapiens (Human))
BDBM3235
PNG
((1R,2R)-2-[(4-hydroxybenzene)amido]cyclopentyl 3,5...)
Show SMILES Oc1ccc(cc1)C(=O)N[C@@H]1CCC[C@H]1OC(=O)c1cc(O)c(C(=O)c2c(O)cccc2NS(=O)(=O)C(F)(F)F)c(O)c1 |r|
Show InChI InChI=1S/C27H23F3N2O10S/c28-27(29,30)43(40,41)32-17-4-1-5-18(34)22(17)24(37)23-19(35)11-14(12-20(23)36)26(39)42-21-6-2-3-16(21)31-25(38)13-7-9-15(33)10-8-13/h1,4-5,7-12,16,21,32-36H,2-3,6H2,(H,31,38)/t16-,21-/m1/s1
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Sphinx Laboratories



Assay Description
PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.


J Med Chem 45: 2624-43 (2002)


Article DOI: 10.1021/jm020018f
BindingDB Entry DOI: 10.7270/Q2BG2M50
More data for this
Ligand-Target Pair
cAMP-dependent protein kinase catalytic subunit alpha


(Bos taurus (bovine))
BDBM3152
PNG
(2-{[2,6-dihydroxy-4-({[(3R,4R)-4-[(4-hydroxybenzen...)
Show SMILES OC(=O)c1cccc(O)c1C(=O)c1c(O)cc(cc1O)C(=O)O[C@@H]1CNC[C@H]1NC(=O)c1ccc(O)cc1 |r|
Show InChI InChI=1S/C26H22N2O10/c29-14-6-4-12(5-7-14)24(34)28-16-10-27-11-20(16)38-26(37)13-8-18(31)22(19(32)9-13)23(33)21-15(25(35)36)2-1-3-17(21)30/h1-9,16,20,27,29-32H,10-11H2,(H,28,34)(H,35,36)/t16-,20-/m1/s1
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n/an/a 60n/an/an/an/an/an/a



Sphinx Laboratories



Assay Description
The activity of PKA, activated by cAMP, is measured by its ability to transfer phosphate from [gamma-32P]ATP to histone.


J Med Chem 45: 2624-43 (2002)


Article DOI: 10.1021/jm020018f
BindingDB Entry DOI: 10.7270/Q2BG2M50
More data for this
Ligand-Target Pair
Protein kinase C alpha type


(Homo sapiens (Human))
BDBM3149
PNG
(2-{[2,6-dihydroxy-4-({[(3R,4R)-3-[(4-hydroxybenzen...)
Show SMILES OC(=O)c1cccc(O)c1C(=O)c1c(O)cc(cc1O)C(=O)O[C@@H]1CCCNC[C@H]1NC(=O)c1ccc(O)cc1 |r|
Show InChI InChI=1S/C28H26N2O10/c31-16-8-6-14(7-9-16)26(36)30-18-13-29-10-2-5-22(18)40-28(39)15-11-20(33)24(21(34)12-15)25(35)23-17(27(37)38)3-1-4-19(23)32/h1,3-4,6-9,11-12,18,22,29,31-34H,2,5,10,13H2,(H,30,36)(H,37,38)/t18-,22-/m1/s1
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n/an/a 67n/an/an/an/an/an/a



Sphinx Laboratories



Assay Description
PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.


J Med Chem 45: 2624-43 (2002)


Article DOI: 10.1021/jm020018f
BindingDB Entry DOI: 10.7270/Q2BG2M50
More data for this
Ligand-Target Pair
Protein kinase C alpha type


(Homo sapiens (Human))
BDBM3235
PNG
((1R,2R)-2-[(4-hydroxybenzene)amido]cyclopentyl 3,5...)
Show SMILES Oc1ccc(cc1)C(=O)N[C@@H]1CCC[C@H]1OC(=O)c1cc(O)c(C(=O)c2c(O)cccc2NS(=O)(=O)C(F)(F)F)c(O)c1 |r|
Show InChI InChI=1S/C27H23F3N2O10S/c28-27(29,30)43(40,41)32-17-4-1-5-18(34)22(17)24(37)23-19(35)11-14(12-20(23)36)26(39)42-21-6-2-3-16(21)31-25(38)13-7-9-15(33)10-8-13/h1,4-5,7-12,16,21,32-36H,2-3,6H2,(H,31,38)/t16-,21-/m1/s1
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Sphinx Laboratories



Assay Description
PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.


J Med Chem 45: 2624-43 (2002)


Article DOI: 10.1021/jm020018f
BindingDB Entry DOI: 10.7270/Q2BG2M50
More data for this
Ligand-Target Pair
Protein kinase C beta type


(Homo sapiens (Human))
BDBM3236
PNG
((1R,2R)-2-[(4-hydroxybenzene)amido]cyclopentyl 3,5...)
Show SMILES CS(=O)(=O)Nc1cccc(O)c1C(=O)c1c(O)cc(cc1O)C(=O)O[C@@H]1CCC[C@H]1NC(=O)c1ccc(O)cc1 |r|
Show InChI InChI=1S/C27H26N2O10S/c1-40(37,38)29-18-5-2-6-19(31)23(18)25(34)24-20(32)12-15(13-21(24)33)27(36)39-22-7-3-4-17(22)28-26(35)14-8-10-16(30)11-9-14/h2,5-6,8-13,17,22,29-33H,3-4,7H2,1H3,(H,28,35)/t17-,22-/m1/s1
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Sphinx Laboratories



Assay Description
PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.


J Med Chem 45: 2624-43 (2002)


Article DOI: 10.1021/jm020018f
BindingDB Entry DOI: 10.7270/Q2BG2M50
More data for this
Ligand-Target Pair
cAMP-dependent protein kinase catalytic subunit alpha


(Bos taurus (bovine))
BDBM3239
PNG
((1R,2R)-2-[(4-hydroxybenzene)amido]cyclopentyl 3,5...)
Show SMILES Oc1ccc(cc1)C(=O)N[C@@H]1CCC[C@H]1OC(=O)c1cc(O)c(C(=O)c2c(O)cccc2-c2nnn[nH]2)c(O)c1 |r|
Show InChI InChI=1S/C27H23N5O8/c33-15-9-7-13(8-10-15)26(38)28-17-4-2-6-21(17)40-27(39)14-11-19(35)23(20(36)12-14)24(37)22-16(3-1-5-18(22)34)25-29-31-32-30-25/h1,3,5,7-12,17,21,33-36H,2,4,6H2,(H,28,38)(H,29,30,31,32)/t17-,21-/m1/s1
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Sphinx Laboratories



Assay Description
The activity of PKA, activated by cAMP, is measured by its ability to transfer phosphate from [gamma-32P]ATP to histone.


J Med Chem 45: 2624-43 (2002)


Article DOI: 10.1021/jm020018f
BindingDB Entry DOI: 10.7270/Q2BG2M50
More data for this
Ligand-Target Pair
cAMP-dependent protein kinase catalytic subunit alpha


(Bos taurus (bovine))
BDBM3231
PNG
((3R,4R)-3-[(4-hydroxybenzene)amido]azepan-4-yl 3,5...)
Show SMILES COc1cccc(O)c1C(=O)c1c(O)cc(cc1O)C(=O)O[C@@H]1CCCNC[C@H]1NC(=O)c1ccc(O)cc1 |r|
Show InChI InChI=1S/C28H28N2O9/c1-38-23-5-2-4-19(32)25(23)26(35)24-20(33)12-16(13-21(24)34)28(37)39-22-6-3-11-29-14-18(22)30-27(36)15-7-9-17(31)10-8-15/h2,4-5,7-10,12-13,18,22,29,31-34H,3,6,11,14H2,1H3,(H,30,36)/t18-,22-/m1/s1
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n/an/a 250n/an/an/an/an/an/a



Sphinx Laboratories



Assay Description
The activity of PKA, activated by cAMP, is measured by its ability to transfer phosphate from [gamma-32P]ATP to histone.


J Med Chem 45: 2624-43 (2002)


Article DOI: 10.1021/jm020018f
BindingDB Entry DOI: 10.7270/Q2BG2M50
More data for this
Ligand-Target Pair
Protein kinase C beta type


(Homo sapiens (Human))
BDBM3230
PNG
((3R,4R)-4-[(4-hydroxybenzene)amido]pyrrolidin-3-yl...)
Show SMILES Oc1ccc(cc1)C(=O)N[C@@H]1CNC[C@H]1OC(=O)c1cc(O)c(C(=O)c2c(O)ccc3CCCCc23)c(O)c1 |r|
Show InChI InChI=1S/C29H28N2O8/c32-18-8-5-16(6-9-18)28(37)31-20-13-30-14-24(20)39-29(38)17-11-22(34)26(23(35)12-17)27(36)25-19-4-2-1-3-15(19)7-10-21(25)33/h5-12,20,24,30,32-35H,1-4,13-14H2,(H,31,37)/t20-,24-/m1/s1
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n/an/a 260n/an/an/an/an/an/a



Sphinx Laboratories



Assay Description
PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.


J Med Chem 45: 2624-43 (2002)


Article DOI: 10.1021/jm020018f
BindingDB Entry DOI: 10.7270/Q2BG2M50
More data for this
Ligand-Target Pair
Protein kinase C beta type


(Homo sapiens (Human))
BDBM3239
PNG
((1R,2R)-2-[(4-hydroxybenzene)amido]cyclopentyl 3,5...)
Show SMILES Oc1ccc(cc1)C(=O)N[C@@H]1CCC[C@H]1OC(=O)c1cc(O)c(C(=O)c2c(O)cccc2-c2nnn[nH]2)c(O)c1 |r|
Show InChI InChI=1S/C27H23N5O8/c33-15-9-7-13(8-10-15)26(38)28-17-4-2-6-21(17)40-27(39)14-11-19(35)23(20(36)12-14)24(37)22-16(3-1-5-18(22)34)25-29-31-32-30-25/h1,3,5,7-12,17,21,33-36H,2,4,6H2,(H,28,38)(H,29,30,31,32)/t17-,21-/m1/s1
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n/an/a 260n/an/an/an/an/an/a



Sphinx Laboratories



Assay Description
PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.


J Med Chem 45: 2624-43 (2002)


Article DOI: 10.1021/jm020018f
BindingDB Entry DOI: 10.7270/Q2BG2M50
More data for this
Ligand-Target Pair
Protein kinase C beta type


(Homo sapiens (Human))
BDBM3220
PNG
(2-{[2,6-dihydroxy-4-({[(1R,2R)-2-[(4-hydroxybenzen...)
Show SMILES OC(=O)c1cccc(O)c1C(=O)c1c(O)cc(CO[C@@H]2CCC[C@H]2NC(=O)c2ccc(O)cc2)cc1O |r|
Show InChI InChI=1S/C27H25NO9/c29-16-9-7-15(8-10-16)26(34)28-18-4-2-6-22(18)37-13-14-11-20(31)24(21(32)12-14)25(33)23-17(27(35)36)3-1-5-19(23)30/h1,3,5,7-12,18,22,29-32H,2,4,6,13H2,(H,28,34)(H,35,36)/t18-,22-/m1/s1
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n/an/a 290n/an/an/an/an/an/a



Sphinx Laboratories



Assay Description
PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.


J Med Chem 45: 2624-43 (2002)


Article DOI: 10.1021/jm020018f
BindingDB Entry DOI: 10.7270/Q2BG2M50
More data for this
Ligand-Target Pair
cAMP-dependent protein kinase catalytic subunit alpha


(Bos taurus (bovine))
BDBM3228
PNG
((3R,4R)-4-[(4-hydroxybenzene)amido]pyrrolidin-3-yl...)
Show SMILES Oc1ccc(cc1)C(=O)N[C@@H]1CNC[C@H]1OC(=O)c1cc(O)c(C(=O)c2c(O)ccc3ccccc23)c(O)c1 |r|
Show InChI InChI=1S/C29H24N2O8/c32-18-8-5-16(6-9-18)28(37)31-20-13-30-14-24(20)39-29(38)17-11-22(34)26(23(35)12-17)27(36)25-19-4-2-1-3-15(19)7-10-21(25)33/h1-12,20,24,30,32-35H,13-14H2,(H,31,37)/t20-,24-/m1/s1
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n/an/a 290n/an/an/an/an/an/a



Sphinx Laboratories



Assay Description
The activity of PKA, activated by cAMP, is measured by its ability to transfer phosphate from [gamma-32P]ATP to histone.


J Med Chem 45: 2624-43 (2002)


Article DOI: 10.1021/jm020018f
BindingDB Entry DOI: 10.7270/Q2BG2M50
More data for this
Ligand-Target Pair
Protein kinase C epsilon type


(Homo sapiens (Human))
BDBM3230
PNG
((3R,4R)-4-[(4-hydroxybenzene)amido]pyrrolidin-3-yl...)
Show SMILES Oc1ccc(cc1)C(=O)N[C@@H]1CNC[C@H]1OC(=O)c1cc(O)c(C(=O)c2c(O)ccc3CCCCc23)c(O)c1 |r|
Show InChI InChI=1S/C29H28N2O8/c32-18-8-5-16(6-9-18)28(37)31-20-13-30-14-24(20)39-29(38)17-11-22(34)26(23(35)12-17)27(36)25-19-4-2-1-3-15(19)7-10-21(25)33/h5-12,20,24,30,32-35H,1-4,13-14H2,(H,31,37)/t20-,24-/m1/s1
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n/an/a 300n/an/an/an/an/an/a



Sphinx Laboratories



Assay Description
PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.


J Med Chem 45: 2624-43 (2002)


Article DOI: 10.1021/jm020018f
BindingDB Entry DOI: 10.7270/Q2BG2M50
More data for this
Ligand-Target Pair
cAMP-dependent protein kinase catalytic subunit alpha


(Bos taurus (bovine))
BDBM3226
PNG
((3R,4R)-3-[(4-hydroxybenzene)amido]azepan-4-yl 3,5...)
Show SMILES Oc1ccc(cc1)C(=O)N[C@@H]1CNCCC[C@H]1OC(=O)c1cc(O)c(C2OC(=O)c3cccc(O)c23)c(O)c1 |r|
Show InChI InChI=1S/C28H26N2O9/c31-16-8-6-14(7-9-16)26(35)30-18-13-29-10-2-5-22(18)38-27(36)15-11-20(33)24(21(34)12-15)25-23-17(28(37)39-25)3-1-4-19(23)32/h1,3-4,6-9,11-12,18,22,25,29,31-34H,2,5,10,13H2,(H,30,35)/t18-,22-,25?/m1/s1
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n/an/a 300n/an/an/an/an/an/a



Sphinx Laboratories



Assay Description
The activity of PKA, activated by cAMP, is measured by its ability to transfer phosphate from [gamma-32P]ATP to histone.


J Med Chem 45: 2624-43 (2002)


Article DOI: 10.1021/jm020018f
BindingDB Entry DOI: 10.7270/Q2BG2M50
More data for this
Ligand-Target Pair
Protein kinase C epsilon type


(Homo sapiens (Human))
BDBM3235
PNG
((1R,2R)-2-[(4-hydroxybenzene)amido]cyclopentyl 3,5...)
Show SMILES Oc1ccc(cc1)C(=O)N[C@@H]1CCC[C@H]1OC(=O)c1cc(O)c(C(=O)c2c(O)cccc2NS(=O)(=O)C(F)(F)F)c(O)c1 |r|
Show InChI InChI=1S/C27H23F3N2O10S/c28-27(29,30)43(40,41)32-17-4-1-5-18(34)22(17)24(37)23-19(35)11-14(12-20(23)36)26(39)42-21-6-2-3-16(21)31-25(38)13-7-9-15(33)10-8-13/h1,4-5,7-12,16,21,32-36H,2-3,6H2,(H,31,38)/t16-,21-/m1/s1
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Sphinx Laboratories



Assay Description
PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.


J Med Chem 45: 2624-43 (2002)


Article DOI: 10.1021/jm020018f
BindingDB Entry DOI: 10.7270/Q2BG2M50
More data for this
Ligand-Target Pair
cAMP-dependent protein kinase catalytic subunit alpha


(Bos taurus (bovine))
BDBM3220
PNG
(2-{[2,6-dihydroxy-4-({[(1R,2R)-2-[(4-hydroxybenzen...)
Show SMILES OC(=O)c1cccc(O)c1C(=O)c1c(O)cc(CO[C@@H]2CCC[C@H]2NC(=O)c2ccc(O)cc2)cc1O |r|
Show InChI InChI=1S/C27H25NO9/c29-16-9-7-15(8-10-16)26(34)28-18-4-2-6-22(18)37-13-14-11-20(31)24(21(32)12-14)25(33)23-17(27(35)36)3-1-5-19(23)30/h1,3,5,7-12,18,22,29-32H,2,4,6,13H2,(H,28,34)(H,35,36)/t18-,22-/m1/s1
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n/an/a 320n/an/an/an/an/an/a



Sphinx Laboratories



Assay Description
The activity of PKA, activated by cAMP, is measured by its ability to transfer phosphate from [gamma-32P]ATP to histone.


J Med Chem 45: 2624-43 (2002)


Article DOI: 10.1021/jm020018f
BindingDB Entry DOI: 10.7270/Q2BG2M50
More data for this
Ligand-Target Pair
cAMP-dependent protein kinase catalytic subunit alpha


(Bos taurus (bovine))
BDBM3227
PNG
(1-{[2,6-dihydroxy-4-({[(3R,4R)-4-[(4-hydroxybenzen...)
Show SMILES OC(=O)c1ccc2ccccc2c1C(=O)c1c(O)cc(cc1O)C(=O)O[C@@H]1CNC[C@H]1NC(=O)c1ccc(O)cc1 |r|
Show InChI InChI=1S/C30H24N2O9/c33-18-8-5-16(6-9-18)28(37)32-21-13-31-14-24(21)41-30(40)17-11-22(34)26(23(35)12-17)27(36)25-19-4-2-1-3-15(19)7-10-20(25)29(38)39/h1-12,21,24,31,33-35H,13-14H2,(H,32,37)(H,38,39)/t21-,24-/m1/s1
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n/an/a 330n/an/an/an/an/an/a



Sphinx Laboratories



Assay Description
The activity of PKA, activated by cAMP, is measured by its ability to transfer phosphate from [gamma-32P]ATP to histone.


J Med Chem 45: 2624-43 (2002)


Article DOI: 10.1021/jm020018f
BindingDB Entry DOI: 10.7270/Q2BG2M50
More data for this
Ligand-Target Pair
Protein kinase C beta type


(Homo sapiens (Human))
BDBM3234
PNG
(1-trans-[4-(2-Carboxymethoxy-6-hydroxybenzoyl)-3,5...)
Show SMILES OC(=O)COc1cccc(O)c1C(=O)c1c(O)cc(cc1O)C(=O)O[C@@H]1CCC[C@H]1NC(=O)c1ccc(O)cc1 |r|
Show InChI InChI=1S/C28H25NO11/c30-16-9-7-14(8-10-16)27(37)29-17-3-1-5-21(17)40-28(38)15-11-19(32)24(20(33)12-15)26(36)25-18(31)4-2-6-22(25)39-13-23(34)35/h2,4,6-12,17,21,30-33H,1,3,5,13H2,(H,29,37)(H,34,35)/t17-,21-/m1/s1
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n/an/a 330n/an/an/an/an/an/a



Sphinx Laboratories



Assay Description
PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.


J Med Chem 45: 2624-43 (2002)


Article DOI: 10.1021/jm020018f
BindingDB Entry DOI: 10.7270/Q2BG2M50
More data for this
Ligand-Target Pair
Protein kinase C alpha type


(Homo sapiens (Human))
BDBM3239
PNG
((1R,2R)-2-[(4-hydroxybenzene)amido]cyclopentyl 3,5...)
Show SMILES Oc1ccc(cc1)C(=O)N[C@@H]1CCC[C@H]1OC(=O)c1cc(O)c(C(=O)c2c(O)cccc2-c2nnn[nH]2)c(O)c1 |r|
Show InChI InChI=1S/C27H23N5O8/c33-15-9-7-13(8-10-15)26(38)28-17-4-2-6-21(17)40-27(39)14-11-19(35)23(20(36)12-14)24(37)22-16(3-1-5-18(22)34)25-29-31-32-30-25/h1,3,5,7-12,17,21,33-36H,2,4,6H2,(H,28,38)(H,29,30,31,32)/t17-,21-/m1/s1
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Sphinx Laboratories



Assay Description
PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.


J Med Chem 45: 2624-43 (2002)


Article DOI: 10.1021/jm020018f
BindingDB Entry DOI: 10.7270/Q2BG2M50
More data for this
Ligand-Target Pair
cAMP-dependent protein kinase catalytic subunit alpha


(Bos taurus (bovine))
BDBM3235
PNG
((1R,2R)-2-[(4-hydroxybenzene)amido]cyclopentyl 3,5...)
Show SMILES Oc1ccc(cc1)C(=O)N[C@@H]1CCC[C@H]1OC(=O)c1cc(O)c(C(=O)c2c(O)cccc2NS(=O)(=O)C(F)(F)F)c(O)c1 |r|
Show InChI InChI=1S/C27H23F3N2O10S/c28-27(29,30)43(40,41)32-17-4-1-5-18(34)22(17)24(37)23-19(35)11-14(12-20(23)36)26(39)42-21-6-2-3-16(21)31-25(38)13-7-9-15(33)10-8-13/h1,4-5,7-12,16,21,32-36H,2-3,6H2,(H,31,38)/t16-,21-/m1/s1
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Sphinx Laboratories



Assay Description
The activity of PKA, activated by cAMP, is measured by its ability to transfer phosphate from [gamma-32P]ATP to histone.


J Med Chem 45: 2624-43 (2002)


Article DOI: 10.1021/jm020018f
BindingDB Entry DOI: 10.7270/Q2BG2M50
More data for this
Ligand-Target Pair
cAMP-dependent protein kinase catalytic subunit alpha


(Bos taurus (bovine))
BDBM3216
PNG
(3-hydroxy-2-{[2-hydroxy-4-({[(1R,2R)-2-[(4-hydroxy...)
Show SMILES OC(=O)c1cccc(O)c1C(=O)c1ccc(cc1O)C(=O)O[C@@H]1CCC[C@H]1NC(=O)c1ccc(O)cc1 |r|
Show InChI InChI=1S/C27H23NO9/c29-16-10-7-14(8-11-16)25(33)28-19-4-2-6-22(19)37-27(36)15-9-12-17(21(31)13-15)24(32)23-18(26(34)35)3-1-5-20(23)30/h1,3,5,7-13,19,22,29-31H,2,4,6H2,(H,28,33)(H,34,35)/t19-,22-/m1/s1
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n/an/a 350n/an/an/an/an/an/a



Sphinx Laboratories



Assay Description
The activity of PKA, activated by cAMP, is measured by its ability to transfer phosphate from [gamma-32P]ATP to histone.


J Med Chem 45: 2624-43 (2002)


Article DOI: 10.1021/jm020018f
BindingDB Entry DOI: 10.7270/Q2BG2M50
More data for this
Ligand-Target Pair
cAMP-dependent protein kinase catalytic subunit alpha


(Bos taurus (bovine))
BDBM3213
PNG
((3R,4R)-3-[(4-hydroxybenzene)amido]azepan-4-yl 4-[...)
Show SMILES COc1cccc(OC)c1C(=O)c1c(O)cc(cc1O)C(=O)O[C@@H]1CCCNC[C@H]1NC(=O)c1ccc(O)cc1 |r|
Show InChI InChI=1S/C29H30N2O9/c1-38-23-5-3-6-24(39-2)26(23)27(35)25-20(33)13-17(14-21(25)34)29(37)40-22-7-4-12-30-15-19(22)31-28(36)16-8-10-18(32)11-9-16/h3,5-6,8-11,13-14,19,22,30,32-34H,4,7,12,15H2,1-2H3,(H,31,36)/t19-,22-/m1/s1
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n/an/a 360n/an/an/an/an/an/a



Sphinx Laboratories



Assay Description
The activity of PKA, activated by cAMP, is measured by its ability to transfer phosphate from [gamma-32P]ATP to histone.


J Med Chem 45: 2624-43 (2002)


Article DOI: 10.1021/jm020018f
BindingDB Entry DOI: 10.7270/Q2BG2M50
More data for this
Ligand-Target Pair
Protein kinase C epsilon type


(Homo sapiens (Human))
BDBM3220
PNG
(2-{[2,6-dihydroxy-4-({[(1R,2R)-2-[(4-hydroxybenzen...)
Show SMILES OC(=O)c1cccc(O)c1C(=O)c1c(O)cc(CO[C@@H]2CCC[C@H]2NC(=O)c2ccc(O)cc2)cc1O |r|
Show InChI InChI=1S/C27H25NO9/c29-16-9-7-15(8-10-16)26(34)28-18-4-2-6-22(18)37-13-14-11-20(31)24(21(32)12-14)25(33)23-17(27(35)36)3-1-5-19(23)30/h1,3,5,7-12,18,22,29-32H,2,4,6,13H2,(H,28,34)(H,35,36)/t18-,22-/m1/s1
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Sphinx Laboratories



Assay Description
PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.


J Med Chem 45: 2624-43 (2002)


Article DOI: 10.1021/jm020018f
BindingDB Entry DOI: 10.7270/Q2BG2M50
More data for this
Ligand-Target Pair
Protein kinase C epsilon type


(Homo sapiens (Human))
BDBM3234
PNG
(1-trans-[4-(2-Carboxymethoxy-6-hydroxybenzoyl)-3,5...)
Show SMILES OC(=O)COc1cccc(O)c1C(=O)c1c(O)cc(cc1O)C(=O)O[C@@H]1CCC[C@H]1NC(=O)c1ccc(O)cc1 |r|
Show InChI InChI=1S/C28H25NO11/c30-16-9-7-14(8-10-16)27(37)29-17-3-1-5-21(17)40-28(38)15-11-19(32)24(20(33)12-15)26(36)25-18(31)4-2-6-22(25)39-13-23(34)35/h2,4,6-12,17,21,30-33H,1,3,5,13H2,(H,29,37)(H,34,35)/t17-,21-/m1/s1
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Sphinx Laboratories



Assay Description
PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.


J Med Chem 45: 2624-43 (2002)


Article DOI: 10.1021/jm020018f
BindingDB Entry DOI: 10.7270/Q2BG2M50
More data for this
Ligand-Target Pair
Protein kinase C alpha type


(Homo sapiens (Human))
BDBM3230
PNG
((3R,4R)-4-[(4-hydroxybenzene)amido]pyrrolidin-3-yl...)
Show SMILES Oc1ccc(cc1)C(=O)N[C@@H]1CNC[C@H]1OC(=O)c1cc(O)c(C(=O)c2c(O)ccc3CCCCc23)c(O)c1 |r|
Show InChI InChI=1S/C29H28N2O8/c32-18-8-5-16(6-9-18)28(37)31-20-13-30-14-24(20)39-29(38)17-11-22(34)26(23(35)12-17)27(36)25-19-4-2-1-3-15(19)7-10-21(25)33/h5-12,20,24,30,32-35H,1-4,13-14H2,(H,31,37)/t20-,24-/m1/s1
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n/an/a 430n/an/an/an/an/an/a



Sphinx Laboratories



Assay Description
PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.


J Med Chem 45: 2624-43 (2002)


Article DOI: 10.1021/jm020018f
BindingDB Entry DOI: 10.7270/Q2BG2M50
More data for this
Ligand-Target Pair
cAMP-dependent protein kinase catalytic subunit alpha


(Bos taurus (bovine))
BDBM3211
PNG
((3R,4R)-3-[(4-hydroxybenzene)amido]azepan-4-yl 3,5...)
Show SMILES Oc1ccc(cc1)C(=O)N[C@@H]1CNCCC[C@H]1OC(=O)c1cc(O)c(C(=O)c2ccccc2O)c(O)c1 |r|
Show InChI InChI=1S/C27H26N2O8/c30-17-9-7-15(8-10-17)26(35)29-19-14-28-11-3-6-23(19)37-27(36)16-12-21(32)24(22(33)13-16)25(34)18-4-1-2-5-20(18)31/h1-2,4-5,7-10,12-13,19,23,28,30-33H,3,6,11,14H2,(H,29,35)/t19-,23-/m1/s1
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n/an/a 440n/an/an/an/a7.530



Sphinx Laboratories



Assay Description
The activity of PKA, activated by cAMP, is measured by its ability to transfer phosphate from [gamma-32P]ATP to histone.


J Med Chem 45: 2624-43 (2002)


Article DOI: 10.1021/jm020018f
BindingDB Entry DOI: 10.7270/Q2BG2M50
More data for this
Ligand-Target Pair
cAMP-dependent protein kinase catalytic subunit alpha


(Bos taurus (bovine))
BDBM3212
PNG
((3R,4R)-3-[(4-hydroxybenzene)amido]azepan-4-yl 4-[...)
Show SMILES Oc1ccc(cc1)C(=O)N[C@@H]1CNCCC[C@H]1OC(=O)c1cc(O)c(C(=O)c2c(O)cccc2O)c(O)c1 |r|
Show InChI InChI=1S/C27H26N2O9/c30-16-8-6-14(7-9-16)26(36)29-17-13-28-10-2-5-22(17)38-27(37)15-11-20(33)24(21(34)12-15)25(35)23-18(31)3-1-4-19(23)32/h1,3-4,6-9,11-12,17,22,28,30-34H,2,5,10,13H2,(H,29,36)/t17-,22-/m1/s1
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n/an/a 440n/an/an/an/a7.530



Sphinx Laboratories



Assay Description
The activity of PKA, activated by cAMP, is measured by its ability to transfer phosphate from [gamma-32P]ATP to histone.


J Med Chem 45: 2624-43 (2002)


Article DOI: 10.1021/jm020018f
BindingDB Entry DOI: 10.7270/Q2BG2M50
More data for this
Ligand-Target Pair
Protein kinase C alpha type


(Homo sapiens (Human))
BDBM3220
PNG
(2-{[2,6-dihydroxy-4-({[(1R,2R)-2-[(4-hydroxybenzen...)
Show SMILES OC(=O)c1cccc(O)c1C(=O)c1c(O)cc(CO[C@@H]2CCC[C@H]2NC(=O)c2ccc(O)cc2)cc1O |r|
Show InChI InChI=1S/C27H25NO9/c29-16-9-7-15(8-10-16)26(34)28-18-4-2-6-22(18)37-13-14-11-20(31)24(21(32)12-14)25(33)23-17(27(35)36)3-1-5-19(23)30/h1,3,5,7-12,18,22,29-32H,2,4,6,13H2,(H,28,34)(H,35,36)/t18-,22-/m1/s1
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n/an/a 460n/an/an/an/an/an/a



Sphinx Laboratories



Assay Description
PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.


J Med Chem 45: 2624-43 (2002)


Article DOI: 10.1021/jm020018f
BindingDB Entry DOI: 10.7270/Q2BG2M50
More data for this
Ligand-Target Pair
cAMP-dependent protein kinase catalytic subunit alpha


(Bos taurus (bovine))
BDBM3225
PNG
(2-{[2,6-dihydroxy-4-({[(3R,4R)-3-[(4-hydroxybenzen...)
Show SMILES OC(=O)c1cccc(O)c1Cc1c(O)cc(cc1O)C(=O)O[C@@H]1CCCNC[C@H]1NC(=O)c1ccc(O)cc1 |r|
Show InChI InChI=1S/C28H28N2O9/c31-17-8-6-15(7-9-17)26(35)30-21-14-29-10-2-5-25(21)39-28(38)16-11-23(33)20(24(34)12-16)13-19-18(27(36)37)3-1-4-22(19)32/h1,3-4,6-9,11-12,21,25,29,31-34H,2,5,10,13-14H2,(H,30,35)(H,36,37)/t21-,25-/m1/s1
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n/an/a 470n/an/an/an/an/an/a



Sphinx Laboratories



Assay Description
The activity of PKA, activated by cAMP, is measured by its ability to transfer phosphate from [gamma-32P]ATP to histone.


J Med Chem 45: 2624-43 (2002)


Article DOI: 10.1021/jm020018f
BindingDB Entry DOI: 10.7270/Q2BG2M50
More data for this
Ligand-Target Pair
cAMP-dependent protein kinase catalytic subunit alpha


(Bos taurus (bovine))
BDBM3241
PNG
((1R,2R)-2-[(4-hydroxybenzene)amido]cyclopentyl 3,5...)
Show SMILES Cn1nnnc1-c1cccc(O)c1C(=O)c1c(O)cc(cc1O)C(=O)O[C@@H]1CCC[C@H]1NC(=O)c1ccc(O)cc1 |r|
Show InChI InChI=1S/C28H25N5O8/c1-33-26(30-31-32-33)17-4-2-6-19(35)23(17)25(38)24-20(36)12-15(13-21(24)37)28(40)41-22-7-3-5-18(22)29-27(39)14-8-10-16(34)11-9-14/h2,4,6,8-13,18,22,34-37H,3,5,7H2,1H3,(H,29,39)/t18-,22-/m1/s1
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n/an/a 470n/an/an/an/an/an/a



Sphinx Laboratories



Assay Description
The activity of PKA, activated by cAMP, is measured by its ability to transfer phosphate from [gamma-32P]ATP to histone.


J Med Chem 45: 2624-43 (2002)


Article DOI: 10.1021/jm020018f
BindingDB Entry DOI: 10.7270/Q2BG2M50
More data for this
Ligand-Target Pair
cAMP-dependent protein kinase catalytic subunit alpha


(Bos taurus (bovine))
BDBM3234
PNG
(1-trans-[4-(2-Carboxymethoxy-6-hydroxybenzoyl)-3,5...)
Show SMILES OC(=O)COc1cccc(O)c1C(=O)c1c(O)cc(cc1O)C(=O)O[C@@H]1CCC[C@H]1NC(=O)c1ccc(O)cc1 |r|
Show InChI InChI=1S/C28H25NO11/c30-16-9-7-14(8-10-16)27(37)29-17-3-1-5-21(17)40-28(38)15-11-19(32)24(20(33)12-15)26(36)25-18(31)4-2-6-22(25)39-13-23(34)35/h2,4,6-12,17,21,30-33H,1,3,5,13H2,(H,29,37)(H,34,35)/t17-,21-/m1/s1
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n/an/a 470n/an/an/an/an/an/a



Sphinx Laboratories



Assay Description
The activity of PKA, activated by cAMP, is measured by its ability to transfer phosphate from [gamma-32P]ATP to histone.


J Med Chem 45: 2624-43 (2002)


Article DOI: 10.1021/jm020018f
BindingDB Entry DOI: 10.7270/Q2BG2M50
More data for this
Ligand-Target Pair
Protein kinase C alpha type


(Homo sapiens (Human))
BDBM3236
PNG
((1R,2R)-2-[(4-hydroxybenzene)amido]cyclopentyl 3,5...)
Show SMILES CS(=O)(=O)Nc1cccc(O)c1C(=O)c1c(O)cc(cc1O)C(=O)O[C@@H]1CCC[C@H]1NC(=O)c1ccc(O)cc1 |r|
Show InChI InChI=1S/C27H26N2O10S/c1-40(37,38)29-18-5-2-6-19(31)23(18)25(34)24-20(32)12-15(13-21(24)33)27(36)39-22-7-3-4-17(22)28-26(35)14-8-10-16(30)11-9-14/h2,5-6,8-13,17,22,29-33H,3-4,7H2,1H3,(H,28,35)/t17-,22-/m1/s1
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n/an/a 500n/an/an/an/an/an/a



Sphinx Laboratories



Assay Description
PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.


J Med Chem 45: 2624-43 (2002)


Article DOI: 10.1021/jm020018f
BindingDB Entry DOI: 10.7270/Q2BG2M50
More data for this
Ligand-Target Pair
cAMP-dependent protein kinase catalytic subunit alpha


(Bos taurus (bovine))
BDBM3232
PNG
((1R,2R)-2-[(4-hydroxybenzene)amido]cyclopentyl 4-[...)
Show SMILES Oc1ccc(cc1)C(=O)N[C@@H]1CCC[C@H]1OC(=O)c1cc(O)c(C(=O)c2c(O)cccc2C#N)c(O)c1 |r|
Show InChI InChI=1S/C27H22N2O8/c28-13-15-3-1-5-19(31)23(15)25(34)24-20(32)11-16(12-21(24)33)27(36)37-22-6-2-4-18(22)29-26(35)14-7-9-17(30)10-8-14/h1,3,5,7-12,18,22,30-33H,2,4,6H2,(H,29,35)/t18-,22-/m1/s1
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n/an/a 500n/an/an/an/an/an/a



Sphinx Laboratories



Assay Description
The activity of PKA, activated by cAMP, is measured by its ability to transfer phosphate from [gamma-32P]ATP to histone.


J Med Chem 45: 2624-43 (2002)


Article DOI: 10.1021/jm020018f
BindingDB Entry DOI: 10.7270/Q2BG2M50
More data for this
Ligand-Target Pair
Protein kinase C beta type


(Homo sapiens (Human))
BDBM3226
PNG
((3R,4R)-3-[(4-hydroxybenzene)amido]azepan-4-yl 3,5...)
Show SMILES Oc1ccc(cc1)C(=O)N[C@@H]1CNCCC[C@H]1OC(=O)c1cc(O)c(C2OC(=O)c3cccc(O)c23)c(O)c1 |r|
Show InChI InChI=1S/C28H26N2O9/c31-16-8-6-14(7-9-16)26(35)30-18-13-29-10-2-5-22(18)38-27(36)15-11-20(33)24(21(34)12-15)25-23-17(28(37)39-25)3-1-4-19(23)32/h1,3-4,6-9,11-12,18,22,25,29,31-34H,2,5,10,13H2,(H,30,35)/t18-,22-,25?/m1/s1
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n/an/a 800n/an/an/an/an/an/a



Sphinx Laboratories



Assay Description
PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.


J Med Chem 45: 2624-43 (2002)


Article DOI: 10.1021/jm020018f
BindingDB Entry DOI: 10.7270/Q2BG2M50
More data for this
Ligand-Target Pair
Protein kinase C epsilon type


(Homo sapiens (Human))
BDBM3232
PNG
((1R,2R)-2-[(4-hydroxybenzene)amido]cyclopentyl 4-[...)
Show SMILES Oc1ccc(cc1)C(=O)N[C@@H]1CCC[C@H]1OC(=O)c1cc(O)c(C(=O)c2c(O)cccc2C#N)c(O)c1 |r|
Show InChI InChI=1S/C27H22N2O8/c28-13-15-3-1-5-19(31)23(15)25(34)24-20(32)11-16(12-21(24)33)27(36)37-22-6-2-4-18(22)29-26(35)14-7-9-17(30)10-8-14/h1,3,5,7-12,18,22,30-33H,2,4,6H2,(H,29,35)/t18-,22-/m1/s1
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n/an/a 830n/an/an/an/an/an/a



Sphinx Laboratories



Assay Description
PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.


J Med Chem 45: 2624-43 (2002)


Article DOI: 10.1021/jm020018f
BindingDB Entry DOI: 10.7270/Q2BG2M50
More data for this
Ligand-Target Pair
Protein kinase C alpha type


(Homo sapiens (Human))
BDBM3212
PNG
((3R,4R)-3-[(4-hydroxybenzene)amido]azepan-4-yl 4-[...)
Show SMILES Oc1ccc(cc1)C(=O)N[C@@H]1CNCCC[C@H]1OC(=O)c1cc(O)c(C(=O)c2c(O)cccc2O)c(O)c1 |r|
Show InChI InChI=1S/C27H26N2O9/c30-16-8-6-14(7-9-16)26(36)29-17-13-28-10-2-5-22(17)38-27(37)15-11-20(33)24(21(34)12-15)25(35)23-18(31)3-1-4-19(23)32/h1,3-4,6-9,11-12,17,22,28,30-34H,2,5,10,13H2,(H,29,36)/t17-,22-/m1/s1
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n/an/a 860n/an/an/an/a7.530



Sphinx Laboratories



Assay Description
PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.


J Med Chem 45: 2624-43 (2002)


Article DOI: 10.1021/jm020018f
BindingDB Entry DOI: 10.7270/Q2BG2M50
More data for this
Ligand-Target Pair
cAMP-dependent protein kinase catalytic subunit alpha


(Bos taurus (bovine))
BDBM3207
PNG
(10''-Deoxybalanol, 4 | 2-{[2,6-dihydroxy-4-({[(3R,...)
Show SMILES OC(=O)c1ccccc1C(=O)c1c(O)cc(cc1O)C(=O)O[C@@H]1CCCNC[C@H]1NC(=O)c1ccc(O)cc1 |r|
Show InChI InChI=1S/C28H26N2O9/c31-17-9-7-15(8-10-17)26(35)30-20-14-29-11-3-6-23(20)39-28(38)16-12-21(32)24(22(33)13-16)25(34)18-4-1-2-5-19(18)27(36)37/h1-2,4-5,7-10,12-13,20,23,29,31-33H,3,6,11,14H2,(H,30,35)(H,36,37)/t20-,23-/m1/s1
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n/an/a 1.00E+3n/an/an/an/a7.530



Sphinx Laboratories



Assay Description
The activity of PKA, activated by cAMP, is measured by its ability to transfer phosphate from [gamma-32P]ATP to histone.


J Med Chem 45: 2624-43 (2002)


Article DOI: 10.1021/jm020018f
BindingDB Entry DOI: 10.7270/Q2BG2M50
More data for this
Ligand-Target Pair
cAMP-dependent protein kinase catalytic subunit alpha


(Bos taurus (bovine))
BDBM3215
PNG
((3R,4R)-4-[(4-hydroxybenzene)amido]pyrrolidin-3-yl...)
Show SMILES Oc1ccc(cc1)C(=O)N[C@@H]1CNC[C@H]1OC(=O)c1cc(O)c2C(=O)c3c(O)cccc3C(=O)c2c1 |r|
Show InChI InChI=1S/C26H20N2O8/c29-14-6-4-12(5-7-14)25(34)28-17-10-27-11-20(17)36-26(35)13-8-16-22(19(31)9-13)24(33)21-15(23(16)32)2-1-3-18(21)30/h1-9,17,20,27,29-31H,10-11H2,(H,28,34)/t17-,20-/m1/s1
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n/an/a 1.20E+3n/an/an/an/an/an/a



Sphinx Laboratories



Assay Description
The activity of PKA, activated by cAMP, is measured by its ability to transfer phosphate from [gamma-32P]ATP to histone.


J Med Chem 45: 2624-43 (2002)


Article DOI: 10.1021/jm020018f
BindingDB Entry DOI: 10.7270/Q2BG2M50
More data for this
Ligand-Target Pair
Protein kinase C beta type


(Homo sapiens (Human))
BDBM3240
PNG
((1R,2R)-2-[(4-hydroxybenzene)amido]cyclopentyl 3,5...)
Show SMILES Cn1nnc(n1)-c1cccc(O)c1C(=O)c1c(O)cc(cc1O)C(=O)O[C@@H]1CCC[C@H]1NC(=O)c1ccc(O)cc1 |r|
Show InChI InChI=1S/C28H25N5O8/c1-33-31-26(30-32-33)17-4-2-6-19(35)23(17)25(38)24-20(36)12-15(13-21(24)37)28(40)41-22-7-3-5-18(22)29-27(39)14-8-10-16(34)11-9-14/h2,4,6,8-13,18,22,34-37H,3,5,7H2,1H3,(H,29,39)/t18-,22-/m1/s1
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n/an/a 1.30E+3n/an/an/an/an/an/a



Sphinx Laboratories



Assay Description
PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.


J Med Chem 45: 2624-43 (2002)


Article DOI: 10.1021/jm020018f
BindingDB Entry DOI: 10.7270/Q2BG2M50
More data for this
Ligand-Target Pair
cAMP-dependent protein kinase catalytic subunit alpha


(Bos taurus (bovine))
BDBM3217
PNG
(3-hydroxy-2-{[4-({[(1R,2R)-2-[(4-hydroxybenzene)am...)
Show SMILES OC(=O)c1cccc(O)c1C(=O)c1ccc(cc1)C(=O)O[C@@H]1CCC[C@H]1NC(=O)c1ccc(O)cc1 |r|
Show InChI InChI=1S/C27H23NO8/c29-18-13-11-16(12-14-18)25(32)28-20-4-2-6-22(20)36-27(35)17-9-7-15(8-10-17)24(31)23-19(26(33)34)3-1-5-21(23)30/h1,3,5,7-14,20,22,29-30H,2,4,6H2,(H,28,32)(H,33,34)/t20-,22-/m1/s1
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n/an/a 1.70E+3n/an/an/an/an/an/a



Sphinx Laboratories



Assay Description
The activity of PKA, activated by cAMP, is measured by its ability to transfer phosphate from [gamma-32P]ATP to histone.


J Med Chem 45: 2624-43 (2002)


Article DOI: 10.1021/jm020018f
BindingDB Entry DOI: 10.7270/Q2BG2M50
More data for this
Ligand-Target Pair
cAMP-dependent protein kinase catalytic subunit alpha


(Bos taurus (bovine))
BDBM3240
PNG
((1R,2R)-2-[(4-hydroxybenzene)amido]cyclopentyl 3,5...)
Show SMILES Cn1nnc(n1)-c1cccc(O)c1C(=O)c1c(O)cc(cc1O)C(=O)O[C@@H]1CCC[C@H]1NC(=O)c1ccc(O)cc1 |r|
Show InChI InChI=1S/C28H25N5O8/c1-33-31-26(30-32-33)17-4-2-6-19(35)23(17)25(38)24-20(36)12-15(13-21(24)37)28(40)41-22-7-3-5-18(22)29-27(39)14-8-10-16(34)11-9-14/h2,4,6,8-13,18,22,34-37H,3,5,7H2,1H3,(H,29,39)/t18-,22-/m1/s1
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n/an/a 1.80E+3n/an/an/an/an/an/a



Sphinx Laboratories



Assay Description
The activity of PKA, activated by cAMP, is measured by its ability to transfer phosphate from [gamma-32P]ATP to histone.


J Med Chem 45: 2624-43 (2002)


Article DOI: 10.1021/jm020018f
BindingDB Entry DOI: 10.7270/Q2BG2M50
More data for this
Ligand-Target Pair
cAMP-dependent protein kinase catalytic subunit alpha


(Bos taurus (bovine))
BDBM3221
PNG
(2-{[2,6-dihydroxy-4-({[(3R,4R)-4-[(4-hydroxybenzen...)
Show SMILES OC(=O)c1ccccc1NC(=O)c1c(O)cc(cc1O)C(=O)O[C@@H]1CNC[C@H]1NC(=O)c1ccc(O)cc1 |r|
Show InChI InChI=1S/C26H23N3O9/c30-15-7-5-13(6-8-15)23(33)29-18-11-27-12-21(18)38-26(37)14-9-19(31)22(20(32)10-14)24(34)28-17-4-2-1-3-16(17)25(35)36/h1-10,18,21,27,30-32H,11-12H2,(H,28,34)(H,29,33)(H,35,36)/t18-,21-/m1/s1
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n/an/a 1.90E+3n/an/an/an/an/an/a



Sphinx Laboratories



Assay Description
The activity of PKA, activated by cAMP, is measured by its ability to transfer phosphate from [gamma-32P]ATP to histone.


J Med Chem 45: 2624-43 (2002)


Article DOI: 10.1021/jm020018f
BindingDB Entry DOI: 10.7270/Q2BG2M50
More data for this
Ligand-Target Pair
Protein kinase C epsilon type


(Homo sapiens (Human))
BDBM3239
PNG
((1R,2R)-2-[(4-hydroxybenzene)amido]cyclopentyl 3,5...)
Show SMILES Oc1ccc(cc1)C(=O)N[C@@H]1CCC[C@H]1OC(=O)c1cc(O)c(C(=O)c2c(O)cccc2-c2nnn[nH]2)c(O)c1 |r|
Show InChI InChI=1S/C27H23N5O8/c33-15-9-7-13(8-10-15)26(38)28-17-4-2-6-21(17)40-27(39)14-11-19(35)23(20(36)12-14)24(37)22-16(3-1-5-18(22)34)25-29-31-32-30-25/h1,3,5,7-12,17,21,33-36H,2,4,6H2,(H,28,38)(H,29,30,31,32)/t17-,21-/m1/s1
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n/an/a 2.00E+3n/an/an/an/an/an/a



Sphinx Laboratories



Assay Description
PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.


J Med Chem 45: 2624-43 (2002)


Article DOI: 10.1021/jm020018f
BindingDB Entry DOI: 10.7270/Q2BG2M50
More data for this
Ligand-Target Pair
Protein kinase C epsilon type


(Homo sapiens (Human))
BDBM3212
PNG
((3R,4R)-3-[(4-hydroxybenzene)amido]azepan-4-yl 4-[...)
Show SMILES Oc1ccc(cc1)C(=O)N[C@@H]1CNCCC[C@H]1OC(=O)c1cc(O)c(C(=O)c2c(O)cccc2O)c(O)c1 |r|
Show InChI InChI=1S/C27H26N2O9/c30-16-8-6-14(7-9-16)26(36)29-17-13-28-10-2-5-22(17)38-27(37)15-11-20(33)24(21(34)12-15)25(35)23-18(31)3-1-4-19(23)32/h1,3-4,6-9,11-12,17,22,28,30-34H,2,5,10,13H2,(H,29,36)/t17-,22-/m1/s1
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n/an/a 2.10E+3n/an/an/an/a7.530



Sphinx Laboratories



Assay Description
PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.


J Med Chem 45: 2624-43 (2002)


Article DOI: 10.1021/jm020018f
BindingDB Entry DOI: 10.7270/Q2BG2M50
More data for this
Ligand-Target Pair
Protein kinase C beta type


(Homo sapiens (Human))
BDBM3232
PNG
((1R,2R)-2-[(4-hydroxybenzene)amido]cyclopentyl 4-[...)
Show SMILES Oc1ccc(cc1)C(=O)N[C@@H]1CCC[C@H]1OC(=O)c1cc(O)c(C(=O)c2c(O)cccc2C#N)c(O)c1 |r|
Show InChI InChI=1S/C27H22N2O8/c28-13-15-3-1-5-19(31)23(15)25(34)24-20(32)11-16(12-21(24)33)27(36)37-22-6-2-4-18(22)29-26(35)14-7-9-17(30)10-8-14/h1,3,5,7-12,18,22,30-33H,2,4,6H2,(H,29,35)/t18-,22-/m1/s1
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n/an/a 2.10E+3n/an/an/an/an/an/a



Sphinx Laboratories



Assay Description
PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.


J Med Chem 45: 2624-43 (2002)


Article DOI: 10.1021/jm020018f
BindingDB Entry DOI: 10.7270/Q2BG2M50
More data for this
Ligand-Target Pair
Protein kinase C alpha type


(Homo sapiens (Human))
BDBM3234
PNG
(1-trans-[4-(2-Carboxymethoxy-6-hydroxybenzoyl)-3,5...)
Show SMILES OC(=O)COc1cccc(O)c1C(=O)c1c(O)cc(cc1O)C(=O)O[C@@H]1CCC[C@H]1NC(=O)c1ccc(O)cc1 |r|
Show InChI InChI=1S/C28H25NO11/c30-16-9-7-14(8-10-16)27(37)29-17-3-1-5-21(17)40-28(38)15-11-19(32)24(20(33)12-15)26(36)25-18(31)4-2-6-22(25)39-13-23(34)35/h2,4,6-12,17,21,30-33H,1,3,5,13H2,(H,29,37)(H,34,35)/t17-,21-/m1/s1
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n/an/a 2.20E+3n/an/an/an/an/an/a



Sphinx Laboratories



Assay Description
PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.


J Med Chem 45: 2624-43 (2002)


Article DOI: 10.1021/jm020018f
BindingDB Entry DOI: 10.7270/Q2BG2M50
More data for this
Ligand-Target Pair
Protein kinase C epsilon type


(Homo sapiens (Human))
BDBM3228
PNG
((3R,4R)-4-[(4-hydroxybenzene)amido]pyrrolidin-3-yl...)
Show SMILES Oc1ccc(cc1)C(=O)N[C@@H]1CNC[C@H]1OC(=O)c1cc(O)c(C(=O)c2c(O)ccc3ccccc23)c(O)c1 |r|
Show InChI InChI=1S/C29H24N2O8/c32-18-8-5-16(6-9-18)28(37)31-20-13-30-14-24(20)39-29(38)17-11-22(34)26(23(35)12-17)27(36)25-19-4-2-1-3-15(19)7-10-21(25)33/h1-12,20,24,30,32-35H,13-14H2,(H,31,37)/t20-,24-/m1/s1
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n/an/a 2.20E+3n/an/an/an/an/an/a



Sphinx Laboratories



Assay Description
PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.


J Med Chem 45: 2624-43 (2002)


Article DOI: 10.1021/jm020018f
BindingDB Entry DOI: 10.7270/Q2BG2M50
More data for this
Ligand-Target Pair
Protein kinase C epsilon type


(Homo sapiens (Human))
BDBM3231
PNG
((3R,4R)-3-[(4-hydroxybenzene)amido]azepan-4-yl 3,5...)
Show SMILES COc1cccc(O)c1C(=O)c1c(O)cc(cc1O)C(=O)O[C@@H]1CCCNC[C@H]1NC(=O)c1ccc(O)cc1 |r|
Show InChI InChI=1S/C28H28N2O9/c1-38-23-5-2-4-19(32)25(23)26(35)24-20(33)12-16(13-21(24)34)28(37)39-22-6-3-11-29-14-18(22)30-27(36)15-7-9-17(31)10-8-15/h2,4-5,7-10,12-13,18,22,29,31-34H,3,6,11,14H2,1H3,(H,30,36)/t18-,22-/m1/s1
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n/an/a 2.60E+3n/an/an/an/an/an/a



Sphinx Laboratories



Assay Description
PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.


J Med Chem 45: 2624-43 (2002)


Article DOI: 10.1021/jm020018f
BindingDB Entry DOI: 10.7270/Q2BG2M50
More data for this
Ligand-Target Pair
Protein kinase C alpha type


(Homo sapiens (Human))
BDBM3216
PNG
(3-hydroxy-2-{[2-hydroxy-4-({[(1R,2R)-2-[(4-hydroxy...)
Show SMILES OC(=O)c1cccc(O)c1C(=O)c1ccc(cc1O)C(=O)O[C@@H]1CCC[C@H]1NC(=O)c1ccc(O)cc1 |r|
Show InChI InChI=1S/C27H23NO9/c29-16-10-7-14(8-11-16)25(33)28-19-4-2-6-22(19)37-27(36)15-9-12-17(21(31)13-15)24(32)23-18(26(34)35)3-1-5-20(23)30/h1,3,5,7-13,19,22,29-31H,2,4,6H2,(H,28,33)(H,34,35)/t19-,22-/m1/s1
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n/an/a 2.60E+3n/an/an/an/an/an/a



Sphinx Laboratories



Assay Description
PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.


J Med Chem 45: 2624-43 (2002)


Article DOI: 10.1021/jm020018f
BindingDB Entry DOI: 10.7270/Q2BG2M50
More data for this
Ligand-Target Pair
Protein kinase C beta type


(Homo sapiens (Human))
BDBM3216
PNG
(3-hydroxy-2-{[2-hydroxy-4-({[(1R,2R)-2-[(4-hydroxy...)
Show SMILES OC(=O)c1cccc(O)c1C(=O)c1ccc(cc1O)C(=O)O[C@@H]1CCC[C@H]1NC(=O)c1ccc(O)cc1 |r|
Show InChI InChI=1S/C27H23NO9/c29-16-10-7-14(8-11-16)25(33)28-19-4-2-6-22(19)37-27(36)15-9-12-17(21(31)13-15)24(32)23-18(26(34)35)3-1-5-20(23)30/h1,3,5,7-13,19,22,29-31H,2,4,6H2,(H,28,33)(H,34,35)/t19-,22-/m1/s1
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n/an/a 2.70E+3n/an/an/an/an/an/a



Sphinx Laboratories



Assay Description
PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.


J Med Chem 45: 2624-43 (2002)


Article DOI: 10.1021/jm020018f
BindingDB Entry DOI: 10.7270/Q2BG2M50
More data for this
Ligand-Target Pair
Protein kinase C epsilon type


(Homo sapiens (Human))
BDBM3215
PNG
((3R,4R)-4-[(4-hydroxybenzene)amido]pyrrolidin-3-yl...)
Show SMILES Oc1ccc(cc1)C(=O)N[C@@H]1CNC[C@H]1OC(=O)c1cc(O)c2C(=O)c3c(O)cccc3C(=O)c2c1 |r|
Show InChI InChI=1S/C26H20N2O8/c29-14-6-4-12(5-7-14)25(34)28-17-10-27-11-20(17)36-26(35)13-8-16-22(19(31)9-13)24(33)21-15(23(16)32)2-1-3-18(21)30/h1-9,17,20,27,29-31H,10-11H2,(H,28,34)/t17-,20-/m1/s1
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n/an/a 3.30E+3n/an/an/an/an/an/a



Sphinx Laboratories



Assay Description
PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.


J Med Chem 45: 2624-43 (2002)


Article DOI: 10.1021/jm020018f
BindingDB Entry DOI: 10.7270/Q2BG2M50
More data for this
Ligand-Target Pair
Protein kinase C beta type


(Homo sapiens (Human))
BDBM3241
PNG
((1R,2R)-2-[(4-hydroxybenzene)amido]cyclopentyl 3,5...)
Show SMILES Cn1nnnc1-c1cccc(O)c1C(=O)c1c(O)cc(cc1O)C(=O)O[C@@H]1CCC[C@H]1NC(=O)c1ccc(O)cc1 |r|
Show InChI InChI=1S/C28H25N5O8/c1-33-26(30-31-32-33)17-4-2-6-19(35)23(17)25(38)24-20(36)12-15(13-21(24)37)28(40)41-22-7-3-5-18(22)29-27(39)14-8-10-16(34)11-9-14/h2,4,6,8-13,18,22,34-37H,3,5,7H2,1H3,(H,29,39)/t18-,22-/m1/s1
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n/an/a 3.50E+3n/an/an/an/an/an/a



Sphinx Laboratories



Assay Description
PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.


J Med Chem 45: 2624-43 (2002)


Article DOI: 10.1021/jm020018f
BindingDB Entry DOI: 10.7270/Q2BG2M50
More data for this
Ligand-Target Pair
Protein kinase C epsilon type


(Homo sapiens (Human))
BDBM3207
PNG
(10''-Deoxybalanol, 4 | 2-{[2,6-dihydroxy-4-({[(3R,...)
Show SMILES OC(=O)c1ccccc1C(=O)c1c(O)cc(cc1O)C(=O)O[C@@H]1CCCNC[C@H]1NC(=O)c1ccc(O)cc1 |r|
Show InChI InChI=1S/C28H26N2O9/c31-17-9-7-15(8-10-17)26(35)30-20-14-29-11-3-6-23(20)39-28(38)16-12-21(32)24(22(33)13-16)25(34)18-4-1-2-5-19(18)27(36)37/h1-2,4-5,7-10,12-13,20,23,29,31-33H,3,6,11,14H2,(H,30,35)(H,36,37)/t20-,23-/m1/s1
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n/an/a 3.50E+3n/an/an/an/a7.530



Sphinx Laboratories



Assay Description
PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.


J Med Chem 45: 2624-43 (2002)


Article DOI: 10.1021/jm020018f
BindingDB Entry DOI: 10.7270/Q2BG2M50
More data for this
Ligand-Target Pair
Protein kinase C alpha type


(Homo sapiens (Human))
BDBM3240
PNG
((1R,2R)-2-[(4-hydroxybenzene)amido]cyclopentyl 3,5...)
Show SMILES Cn1nnc(n1)-c1cccc(O)c1C(=O)c1c(O)cc(cc1O)C(=O)O[C@@H]1CCC[C@H]1NC(=O)c1ccc(O)cc1 |r|
Show InChI InChI=1S/C28H25N5O8/c1-33-31-26(30-32-33)17-4-2-6-19(35)23(17)25(38)24-20(36)12-15(13-21(24)37)28(40)41-22-7-3-5-18(22)29-27(39)14-8-10-16(34)11-9-14/h2,4,6,8-13,18,22,34-37H,3,5,7H2,1H3,(H,29,39)/t18-,22-/m1/s1
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n/an/a 3.60E+3n/an/an/an/an/an/a



Sphinx Laboratories



Assay Description
PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.


J Med Chem 45: 2624-43 (2002)


Article DOI: 10.1021/jm020018f
BindingDB Entry DOI: 10.7270/Q2BG2M50
More data for this
Ligand-Target Pair
Protein kinase C alpha type


(Homo sapiens (Human))
BDBM3232
PNG
((1R,2R)-2-[(4-hydroxybenzene)amido]cyclopentyl 4-[...)
Show SMILES Oc1ccc(cc1)C(=O)N[C@@H]1CCC[C@H]1OC(=O)c1cc(O)c(C(=O)c2c(O)cccc2C#N)c(O)c1 |r|
Show InChI InChI=1S/C27H22N2O8/c28-13-15-3-1-5-19(31)23(15)25(34)24-20(32)11-16(12-21(24)33)27(36)37-22-6-2-4-18(22)29-26(35)14-7-9-17(30)10-8-14/h1,3,5,7-12,18,22,30-33H,2,4,6H2,(H,29,35)/t18-,22-/m1/s1
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n/an/a 3.70E+3n/an/an/an/an/an/a



Sphinx Laboratories



Assay Description
PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.


J Med Chem 45: 2624-43 (2002)


Article DOI: 10.1021/jm020018f
BindingDB Entry DOI: 10.7270/Q2BG2M50
More data for this
Ligand-Target Pair
Protein kinase C beta type


(Homo sapiens (Human))
BDBM3207
PNG
(10''-Deoxybalanol, 4 | 2-{[2,6-dihydroxy-4-({[(3R,...)
Show SMILES OC(=O)c1ccccc1C(=O)c1c(O)cc(cc1O)C(=O)O[C@@H]1CCCNC[C@H]1NC(=O)c1ccc(O)cc1 |r|
Show InChI InChI=1S/C28H26N2O9/c31-17-9-7-15(8-10-17)26(35)30-20-14-29-11-3-6-23(20)39-28(38)16-12-21(32)24(22(33)13-16)25(34)18-4-1-2-5-19(18)27(36)37/h1-2,4-5,7-10,12-13,20,23,29,31-33H,3,6,11,14H2,(H,30,35)(H,36,37)/t20-,23-/m1/s1
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n/an/a 3.70E+3n/an/an/an/a7.530



Sphinx Laboratories



Assay Description
PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.


J Med Chem 45: 2624-43 (2002)


Article DOI: 10.1021/jm020018f
BindingDB Entry DOI: 10.7270/Q2BG2M50
More data for this
Ligand-Target Pair
Protein kinase C epsilon type


(Homo sapiens (Human))
BDBM3240
PNG
((1R,2R)-2-[(4-hydroxybenzene)amido]cyclopentyl 3,5...)
Show SMILES Cn1nnc(n1)-c1cccc(O)c1C(=O)c1c(O)cc(cc1O)C(=O)O[C@@H]1CCC[C@H]1NC(=O)c1ccc(O)cc1 |r|
Show InChI InChI=1S/C28H25N5O8/c1-33-31-26(30-32-33)17-4-2-6-19(35)23(17)25(38)24-20(36)12-15(13-21(24)37)28(40)41-22-7-3-5-18(22)29-27(39)14-8-10-16(34)11-9-14/h2,4,6,8-13,18,22,34-37H,3,5,7H2,1H3,(H,29,39)/t18-,22-/m1/s1
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n/an/a 3.80E+3n/an/an/an/an/an/a



Sphinx Laboratories



Assay Description
PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.


J Med Chem 45: 2624-43 (2002)


Article DOI: 10.1021/jm020018f
BindingDB Entry DOI: 10.7270/Q2BG2M50
More data for this
Ligand-Target Pair
cAMP-dependent protein kinase catalytic subunit alpha


(Bos taurus (bovine))
BDBM3233
PNG
((1R,2R)-2-[(4-hydroxybenzene)amido]cyclopentyl 4-{...)
Show SMILES NCCOc1cccc(O)c1C(=O)c1c(O)cc(cc1O)C(=O)O[C@@H]1CCC[C@H]1NC(=O)c1ccc(O)cc1 |r|
Show InChI InChI=1S/C28H28N2O9/c29-11-12-38-23-6-2-4-19(32)25(23)26(35)24-20(33)13-16(14-21(24)34)28(37)39-22-5-1-3-18(22)30-27(36)15-7-9-17(31)10-8-15/h2,4,6-10,13-14,18,22,31-34H,1,3,5,11-12,29H2,(H,30,36)/t18-,22-/m1/s1
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n/an/a 3.90E+3n/an/an/an/an/an/a



Sphinx Laboratories



Assay Description
The activity of PKA, activated by cAMP, is measured by its ability to transfer phosphate from [gamma-32P]ATP to histone.


J Med Chem 45: 2624-43 (2002)


Article DOI: 10.1021/jm020018f
BindingDB Entry DOI: 10.7270/Q2BG2M50
More data for this
Ligand-Target Pair
cAMP-dependent protein kinase catalytic subunit alpha


(Bos taurus (bovine))
BDBM3219
PNG
((3R,4R)-3-[(4-hydroxybenzene)amido]azepan-4-yl 4-[...)
Show SMILES COc1cc(cc(OC)c1C(=O)c1c(O)cccc1O)C(=O)O[C@@H]1CCCNC[C@H]1NC(=O)c1ccc(O)cc1 |r|
Show InChI InChI=1S/C29H30N2O9/c1-38-23-13-17(14-24(39-2)26(23)27(35)25-20(33)5-3-6-21(25)34)29(37)40-22-7-4-12-30-15-19(22)31-28(36)16-8-10-18(32)11-9-16/h3,5-6,8-11,13-14,19,22,30,32-34H,4,7,12,15H2,1-2H3,(H,31,36)/t19-,22-/m1/s1
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n/an/a 4.30E+3n/an/an/an/an/an/a



Sphinx Laboratories



Assay Description
The activity of PKA, activated by cAMP, is measured by its ability to transfer phosphate from [gamma-32P]ATP to histone.


J Med Chem 45: 2624-43 (2002)


Article DOI: 10.1021/jm020018f
BindingDB Entry DOI: 10.7270/Q2BG2M50
More data for this
Ligand-Target Pair
Protein kinase C epsilon type


(Homo sapiens (Human))
BDBM3216
PNG
(3-hydroxy-2-{[2-hydroxy-4-({[(1R,2R)-2-[(4-hydroxy...)
Show SMILES OC(=O)c1cccc(O)c1C(=O)c1ccc(cc1O)C(=O)O[C@@H]1CCC[C@H]1NC(=O)c1ccc(O)cc1 |r|
Show InChI InChI=1S/C27H23NO9/c29-16-10-7-14(8-11-16)25(33)28-19-4-2-6-22(19)37-27(36)15-9-12-17(21(31)13-15)24(32)23-18(26(34)35)3-1-5-20(23)30/h1,3,5,7-13,19,22,29-31H,2,4,6H2,(H,28,33)(H,34,35)/t19-,22-/m1/s1
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n/an/a 4.30E+3n/an/an/an/an/an/a



Sphinx Laboratories



Assay Description
PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.


J Med Chem 45: 2624-43 (2002)


Article DOI: 10.1021/jm020018f
BindingDB Entry DOI: 10.7270/Q2BG2M50
More data for this
Ligand-Target Pair
Protein kinase C beta type


(Homo sapiens (Human))
BDBM3217
PNG
(3-hydroxy-2-{[4-({[(1R,2R)-2-[(4-hydroxybenzene)am...)
Show SMILES OC(=O)c1cccc(O)c1C(=O)c1ccc(cc1)C(=O)O[C@@H]1CCC[C@H]1NC(=O)c1ccc(O)cc1 |r|
Show InChI InChI=1S/C27H23NO8/c29-18-13-11-16(12-14-18)25(32)28-20-4-2-6-22(20)36-27(35)17-9-7-15(8-10-17)24(31)23-19(26(33)34)3-1-5-21(23)30/h1,3,5,7-14,20,22,29-30H,2,4,6H2,(H,28,32)(H,33,34)/t20-,22-/m1/s1
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n/an/a 4.50E+3n/an/an/an/an/an/a



Sphinx Laboratories



Assay Description
PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.


J Med Chem 45: 2624-43 (2002)


Article DOI: 10.1021/jm020018f
BindingDB Entry DOI: 10.7270/Q2BG2M50
More data for this
Ligand-Target Pair
Protein kinase C epsilon type


(Homo sapiens (Human))
BDBM3227
PNG
(1-{[2,6-dihydroxy-4-({[(3R,4R)-4-[(4-hydroxybenzen...)
Show SMILES OC(=O)c1ccc2ccccc2c1C(=O)c1c(O)cc(cc1O)C(=O)O[C@@H]1CNC[C@H]1NC(=O)c1ccc(O)cc1 |r|
Show InChI InChI=1S/C30H24N2O9/c33-18-8-5-16(6-9-18)28(37)32-21-13-31-14-24(21)41-30(40)17-11-22(34)26(23(35)12-17)27(36)25-19-4-2-1-3-15(19)7-10-20(25)29(38)39/h1-12,21,24,31,33-35H,13-14H2,(H,32,37)(H,38,39)/t21-,24-/m1/s1
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n/an/a 4.60E+3n/an/an/an/an/an/a



Sphinx Laboratories



Assay Description
PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.


J Med Chem 45: 2624-43 (2002)


Article DOI: 10.1021/jm020018f
BindingDB Entry DOI: 10.7270/Q2BG2M50
More data for this
Ligand-Target Pair
Protein kinase C epsilon type


(Homo sapiens (Human))
BDBM3241
PNG
((1R,2R)-2-[(4-hydroxybenzene)amido]cyclopentyl 3,5...)
Show SMILES Cn1nnnc1-c1cccc(O)c1C(=O)c1c(O)cc(cc1O)C(=O)O[C@@H]1CCC[C@H]1NC(=O)c1ccc(O)cc1 |r|
Show InChI InChI=1S/C28H25N5O8/c1-33-26(30-31-32-33)17-4-2-6-19(35)23(17)25(38)24-20(36)12-15(13-21(24)37)28(40)41-22-7-3-5-18(22)29-27(39)14-8-10-16(34)11-9-14/h2,4,6,8-13,18,22,34-37H,3,5,7H2,1H3,(H,29,39)/t18-,22-/m1/s1
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n/an/a 4.70E+3n/an/an/an/an/an/a



Sphinx Laboratories



Assay Description
PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.


J Med Chem 45: 2624-43 (2002)


Article DOI: 10.1021/jm020018f
BindingDB Entry DOI: 10.7270/Q2BG2M50
More data for this
Ligand-Target Pair
Protein kinase C beta type


(Homo sapiens (Human))
BDBM3238
PNG
((1R,2R)-2-[(4-hydroxybenzene)amido]cyclopentyl 4-[...)
Show SMILES CC(=O)Nc1cccc(O)c1C(=O)c1c(O)cc(cc1O)C(=O)O[C@@H]1CCC[C@H]1NC(=O)c1ccc(O)cc1 |r|
Show InChI InChI=1S/C28H26N2O9/c1-14(31)29-19-5-2-6-20(33)24(19)26(36)25-21(34)12-16(13-22(25)35)28(38)39-23-7-3-4-18(23)30-27(37)15-8-10-17(32)11-9-15/h2,5-6,8-13,18,23,32-35H,3-4,7H2,1H3,(H,29,31)(H,30,37)/t18-,23-/m1/s1
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n/an/a 4.80E+3n/an/an/an/an/an/a



Sphinx Laboratories



Assay Description
PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.


J Med Chem 45: 2624-43 (2002)


Article DOI: 10.1021/jm020018f
BindingDB Entry DOI: 10.7270/Q2BG2M50
More data for this
Ligand-Target Pair
Protein kinase C beta type


(Homo sapiens (Human))
BDBM3225
PNG
(2-{[2,6-dihydroxy-4-({[(3R,4R)-3-[(4-hydroxybenzen...)
Show SMILES OC(=O)c1cccc(O)c1Cc1c(O)cc(cc1O)C(=O)O[C@@H]1CCCNC[C@H]1NC(=O)c1ccc(O)cc1 |r|
Show InChI InChI=1S/C28H28N2O9/c31-17-8-6-15(7-9-17)26(35)30-21-14-29-10-2-5-25(21)39-28(38)16-11-23(33)20(24(34)12-16)13-19-18(27(36)37)3-1-4-22(19)32/h1,3-4,6-9,11-12,21,25,29,31-34H,2,5,10,13-14H2,(H,30,35)(H,36,37)/t21-,25-/m1/s1
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n/an/a>5.00E+3n/an/an/an/an/an/a



Sphinx Laboratories



Assay Description
PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.


J Med Chem 45: 2624-43 (2002)


Article DOI: 10.1021/jm020018f
BindingDB Entry DOI: 10.7270/Q2BG2M50
More data for this
Ligand-Target Pair
Protein kinase C epsilon type


(Homo sapiens (Human))
BDBM3225
PNG
(2-{[2,6-dihydroxy-4-({[(3R,4R)-3-[(4-hydroxybenzen...)
Show SMILES OC(=O)c1cccc(O)c1Cc1c(O)cc(cc1O)C(=O)O[C@@H]1CCCNC[C@H]1NC(=O)c1ccc(O)cc1 |r|
Show InChI InChI=1S/C28H28N2O9/c31-17-8-6-15(7-9-17)26(35)30-21-14-29-10-2-5-25(21)39-28(38)16-11-23(33)20(24(34)12-16)13-19-18(27(36)37)3-1-4-22(19)32/h1,3-4,6-9,11-12,21,25,29,31-34H,2,5,10,13-14H2,(H,30,35)(H,36,37)/t21-,25-/m1/s1
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n/an/a>5.00E+3n/an/an/an/an/an/a



Sphinx Laboratories



Assay Description
PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.


J Med Chem 45: 2624-43 (2002)


Article DOI: 10.1021/jm020018f
BindingDB Entry DOI: 10.7270/Q2BG2M50
More data for this
Ligand-Target Pair
Protein kinase C epsilon type


(Homo sapiens (Human))
BDBM3233
PNG
((1R,2R)-2-[(4-hydroxybenzene)amido]cyclopentyl 4-{...)
Show SMILES NCCOc1cccc(O)c1C(=O)c1c(O)cc(cc1O)C(=O)O[C@@H]1CCC[C@H]1NC(=O)c1ccc(O)cc1 |r|
Show InChI InChI=1S/C28H28N2O9/c29-11-12-38-23-6-2-4-19(32)25(23)26(35)24-20(33)13-16(14-21(24)34)28(37)39-22-5-1-3-18(22)30-27(36)15-7-9-17(31)10-8-15/h2,4,6-10,13-14,18,22,31-34H,1,3,5,11-12,29H2,(H,30,36)/t18-,22-/m1/s1
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n/an/a 5.00E+3n/an/an/an/an/an/a



Sphinx Laboratories



Assay Description
PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.


J Med Chem 45: 2624-43 (2002)


Article DOI: 10.1021/jm020018f
BindingDB Entry DOI: 10.7270/Q2BG2M50
More data for this
Ligand-Target Pair
Protein kinase C alpha type


(Homo sapiens (Human))
BDBM3225
PNG
(2-{[2,6-dihydroxy-4-({[(3R,4R)-3-[(4-hydroxybenzen...)
Show SMILES OC(=O)c1cccc(O)c1Cc1c(O)cc(cc1O)C(=O)O[C@@H]1CCCNC[C@H]1NC(=O)c1ccc(O)cc1 |r|
Show InChI InChI=1S/C28H28N2O9/c31-17-8-6-15(7-9-17)26(35)30-21-14-29-10-2-5-25(21)39-28(38)16-11-23(33)20(24(34)12-16)13-19-18(27(36)37)3-1-4-22(19)32/h1,3-4,6-9,11-12,21,25,29,31-34H,2,5,10,13-14H2,(H,30,35)(H,36,37)/t21-,25-/m1/s1
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n/an/a>5.00E+3n/an/an/an/an/an/a



Sphinx Laboratories



Assay Description
PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.


J Med Chem 45: 2624-43 (2002)


Article DOI: 10.1021/jm020018f
BindingDB Entry DOI: 10.7270/Q2BG2M50
More data for this
Ligand-Target Pair
Protein kinase C alpha type


(Homo sapiens (Human))
BDBM3228
PNG
((3R,4R)-4-[(4-hydroxybenzene)amido]pyrrolidin-3-yl...)
Show SMILES Oc1ccc(cc1)C(=O)N[C@@H]1CNC[C@H]1OC(=O)c1cc(O)c(C(=O)c2c(O)ccc3ccccc23)c(O)c1 |r|
Show InChI InChI=1S/C29H24N2O8/c32-18-8-5-16(6-9-18)28(37)31-20-13-30-14-24(20)39-29(38)17-11-22(34)26(23(35)12-17)27(36)25-19-4-2-1-3-15(19)7-10-21(25)33/h1-12,20,24,30,32-35H,13-14H2,(H,31,37)/t20-,24-/m1/s1
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n/an/a 5.60E+3n/an/an/an/an/an/a



Sphinx Laboratories



Assay Description
PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.


J Med Chem 45: 2624-43 (2002)


Article DOI: 10.1021/jm020018f
BindingDB Entry DOI: 10.7270/Q2BG2M50
More data for this
Ligand-Target Pair
Protein kinase C beta type


(Homo sapiens (Human))
BDBM3228
PNG
((3R,4R)-4-[(4-hydroxybenzene)amido]pyrrolidin-3-yl...)
Show SMILES Oc1ccc(cc1)C(=O)N[C@@H]1CNC[C@H]1OC(=O)c1cc(O)c(C(=O)c2c(O)ccc3ccccc23)c(O)c1 |r|
Show InChI InChI=1S/C29H24N2O8/c32-18-8-5-16(6-9-18)28(37)31-20-13-30-14-24(20)39-29(38)17-11-22(34)26(23(35)12-17)27(36)25-19-4-2-1-3-15(19)7-10-21(25)33/h1-12,20,24,30,32-35H,13-14H2,(H,31,37)/t20-,24-/m1/s1
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n/an/a 5.60E+3n/an/an/an/an/an/a



Sphinx Laboratories



Assay Description
PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.


J Med Chem 45: 2624-43 (2002)


Article DOI: 10.1021/jm020018f
BindingDB Entry DOI: 10.7270/Q2BG2M50
More data for this
Ligand-Target Pair
cAMP-dependent protein kinase catalytic subunit alpha


(Bos taurus (bovine))
BDBM3209
PNG
((1R,2R)-2-{[2,6-dihydroxy-4-({[(3R,4R)-3-[(4-hydro...)
Show SMILES OC(=O)[C@@H]1CCCC[C@H]1C(=O)c1c(O)cc(cc1O)C(=O)O[C@@H]1CCCNC[C@H]1NC(=O)c1ccc(O)cc1 |r|
Show InChI InChI=1S/C28H32N2O9/c31-17-9-7-15(8-10-17)26(35)30-20-14-29-11-3-6-23(20)39-28(38)16-12-21(32)24(22(33)13-16)25(34)18-4-1-2-5-19(18)27(36)37/h7-10,12-13,18-20,23,29,31-33H,1-6,11,14H2,(H,30,35)(H,36,37)/t18-,19-,20-,23-/m1/s1
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n/an/a 6.70E+3n/an/an/an/a7.530



Sphinx Laboratories



Assay Description
The activity of PKA, activated by cAMP, is measured by its ability to transfer phosphate from [gamma-32P]ATP to histone.


J Med Chem 45: 2624-43 (2002)


Article DOI: 10.1021/jm020018f
BindingDB Entry DOI: 10.7270/Q2BG2M50
More data for this
Ligand-Target Pair
Protein kinase C epsilon type


(Homo sapiens (Human))
BDBM3213
PNG
((3R,4R)-3-[(4-hydroxybenzene)amido]azepan-4-yl 4-[...)
Show SMILES COc1cccc(OC)c1C(=O)c1c(O)cc(cc1O)C(=O)O[C@@H]1CCCNC[C@H]1NC(=O)c1ccc(O)cc1 |r|
Show InChI InChI=1S/C29H30N2O9/c1-38-23-5-3-6-24(39-2)26(23)27(35)25-20(33)13-17(14-21(25)34)29(37)40-22-7-4-12-30-15-19(22)31-28(36)16-8-10-18(32)11-9-16/h3,5-6,8-11,13-14,19,22,30,32-34H,4,7,12,15H2,1-2H3,(H,31,36)/t19-,22-/m1/s1
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n/an/a 6.70E+3n/an/an/an/an/an/a



Sphinx Laboratories



Assay Description
PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.


J Med Chem 45: 2624-43 (2002)


Article DOI: 10.1021/jm020018f
BindingDB Entry DOI: 10.7270/Q2BG2M50
More data for this
Ligand-Target Pair
Protein kinase C beta type


(Homo sapiens (Human))
BDBM3212
PNG
((3R,4R)-3-[(4-hydroxybenzene)amido]azepan-4-yl 4-[...)
Show SMILES Oc1ccc(cc1)C(=O)N[C@@H]1CNCCC[C@H]1OC(=O)c1cc(O)c(C(=O)c2c(O)cccc2O)c(O)c1 |r|
Show InChI InChI=1S/C27H26N2O9/c30-16-8-6-14(7-9-16)26(36)29-17-13-28-10-2-5-22(17)38-27(37)15-11-20(33)24(21(34)12-15)25(35)23-18(31)3-1-4-19(23)32/h1,3-4,6-9,11-12,17,22,28,30-34H,2,5,10,13H2,(H,29,36)/t17-,22-/m1/s1
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n/an/a 7.60E+3n/an/an/an/a7.530



Sphinx Laboratories



Assay Description
PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.


J Med Chem 45: 2624-43 (2002)


Article DOI: 10.1021/jm020018f
BindingDB Entry DOI: 10.7270/Q2BG2M50
More data for this
Ligand-Target Pair
Protein kinase C alpha type


(Homo sapiens (Human))
BDBM3227
PNG
(1-{[2,6-dihydroxy-4-({[(3R,4R)-4-[(4-hydroxybenzen...)
Show SMILES OC(=O)c1ccc2ccccc2c1C(=O)c1c(O)cc(cc1O)C(=O)O[C@@H]1CNC[C@H]1NC(=O)c1ccc(O)cc1 |r|
Show InChI InChI=1S/C30H24N2O9/c33-18-8-5-16(6-9-18)28(37)32-21-13-31-14-24(21)41-30(40)17-11-22(34)26(23(35)12-17)27(36)25-19-4-2-1-3-15(19)7-10-20(25)29(38)39/h1-12,21,24,31,33-35H,13-14H2,(H,32,37)(H,38,39)/t21-,24-/m1/s1
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n/an/a 7.80E+3n/an/an/an/an/an/a



Sphinx Laboratories



Assay Description
PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.


J Med Chem 45: 2624-43 (2002)


Article DOI: 10.1021/jm020018f
BindingDB Entry DOI: 10.7270/Q2BG2M50
More data for this
Ligand-Target Pair
cAMP-dependent protein kinase catalytic subunit alpha


(Bos taurus (bovine))
BDBM3208
PNG
((1S,2R)-2-{[2,6-dihydroxy-4-({[(3R,4R)-3-[(4-hydro...)
Show SMILES OC(=O)[C@H]1CCCC[C@H]1C(=O)c1c(O)cc(cc1O)C(=O)O[C@@H]1CCCNC[C@H]1NC(=O)c1ccc(O)cc1 |r|
Show InChI InChI=1S/C28H32N2O9/c31-17-9-7-15(8-10-17)26(35)30-20-14-29-11-3-6-23(20)39-28(38)16-12-21(32)24(22(33)13-16)25(34)18-4-1-2-5-19(18)27(36)37/h7-10,12-13,18-20,23,29,31-33H,1-6,11,14H2,(H,30,35)(H,36,37)/t18-,19+,20-,23-/m1/s1
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n/an/a 7.90E+3n/an/an/an/a7.530



Sphinx Laboratories



Assay Description
The activity of PKA, activated by cAMP, is measured by its ability to transfer phosphate from [gamma-32P]ATP to histone.


J Med Chem 45: 2624-43 (2002)


Article DOI: 10.1021/jm020018f
BindingDB Entry DOI: 10.7270/Q2BG2M50
More data for this
Ligand-Target Pair
Protein kinase C beta type


(Homo sapiens (Human))
BDBM3227
PNG
(1-{[2,6-dihydroxy-4-({[(3R,4R)-4-[(4-hydroxybenzen...)
Show SMILES OC(=O)c1ccc2ccccc2c1C(=O)c1c(O)cc(cc1O)C(=O)O[C@@H]1CNC[C@H]1NC(=O)c1ccc(O)cc1 |r|
Show InChI InChI=1S/C30H24N2O9/c33-18-8-5-16(6-9-18)28(37)32-21-13-31-14-24(21)41-30(40)17-11-22(34)26(23(35)12-17)27(36)25-19-4-2-1-3-15(19)7-10-20(25)29(38)39/h1-12,21,24,31,33-35H,13-14H2,(H,32,37)(H,38,39)/t21-,24-/m1/s1
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n/an/a 8.00E+3n/an/an/an/an/an/a



Sphinx Laboratories



Assay Description
PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.


J Med Chem 45: 2624-43 (2002)


Article DOI: 10.1021/jm020018f
BindingDB Entry DOI: 10.7270/Q2BG2M50
More data for this
Ligand-Target Pair
Protein kinase C epsilon type


(Homo sapiens (Human))
BDBM3211
PNG
((3R,4R)-3-[(4-hydroxybenzene)amido]azepan-4-yl 3,5...)
Show SMILES Oc1ccc(cc1)C(=O)N[C@@H]1CNCCC[C@H]1OC(=O)c1cc(O)c(C(=O)c2ccccc2O)c(O)c1 |r|
Show InChI InChI=1S/C27H26N2O8/c30-17-9-7-15(8-10-17)26(35)29-19-14-28-11-3-6-23(19)37-27(36)16-12-21(32)24(22(33)13-16)25(34)18-4-1-2-5-20(18)31/h1-2,4-5,7-10,12-13,19,23,28,30-33H,3,6,11,14H2,(H,29,35)/t19-,23-/m1/s1
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n/an/a 8.00E+3n/an/an/an/a7.530



Sphinx Laboratories



Assay Description
PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.


J Med Chem 45: 2624-43 (2002)


Article DOI: 10.1021/jm020018f
BindingDB Entry DOI: 10.7270/Q2BG2M50
More data for this
Ligand-Target Pair
Protein kinase C epsilon type


(Homo sapiens (Human))
BDBM3210
PNG
(2-{[2,6-dihydroxy-4-({[(3R,4R)-3-[(4-hydroxybenzen...)
Show SMILES OC(=O)c1cccnc1C(=O)c1c(O)cc(cc1O)C(=O)O[C@@H]1CCCNC[C@H]1NC(=O)c1ccc(O)cc1 |r|
Show InChI InChI=1S/C27H25N3O9/c31-16-7-5-14(6-8-16)25(35)30-18-13-28-9-2-4-21(18)39-27(38)15-11-19(32)22(20(33)12-15)24(34)23-17(26(36)37)3-1-10-29-23/h1,3,5-8,10-12,18,21,28,31-33H,2,4,9,13H2,(H,30,35)(H,36,37)/t18-,21-/m1/s1
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n/an/a 8.10E+3n/an/an/an/a7.530



Sphinx Laboratories



Assay Description
PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.


J Med Chem 45: 2624-43 (2002)


Article DOI: 10.1021/jm020018f
BindingDB Entry DOI: 10.7270/Q2BG2M50
More data for this
Ligand-Target Pair
Protein kinase C beta type


(Homo sapiens (Human))
BDBM3231
PNG
((3R,4R)-3-[(4-hydroxybenzene)amido]azepan-4-yl 3,5...)
Show SMILES COc1cccc(O)c1C(=O)c1c(O)cc(cc1O)C(=O)O[C@@H]1CCCNC[C@H]1NC(=O)c1ccc(O)cc1 |r|
Show InChI InChI=1S/C28H28N2O9/c1-38-23-5-2-4-19(32)25(23)26(35)24-20(33)12-16(13-21(24)34)28(37)39-22-6-3-11-29-14-18(22)30-27(36)15-7-9-17(31)10-8-15/h2,4-5,7-10,12-13,18,22,29,31-34H,3,6,11,14H2,1H3,(H,30,36)/t18-,22-/m1/s1
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n/an/a 9.50E+3n/an/an/an/an/an/a



Sphinx Laboratories



Assay Description
PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.


J Med Chem 45: 2624-43 (2002)


Article DOI: 10.1021/jm020018f
BindingDB Entry DOI: 10.7270/Q2BG2M50
More data for this
Ligand-Target Pair
Protein kinase C epsilon type


(Homo sapiens (Human))
BDBM3214
PNG
(4-trans-[(1-Carboxy-8-hydroxy-9-oxoxanthen-6-yl)ca...)
Show SMILES OC(=O)c1cccc2oc3cc(cc(O)c3c(=O)c12)C(=O)O[C@@H]1CCCNC[C@H]1NC(=O)c1ccc(O)cc1 |r|
Show InChI InChI=1S/C28H24N2O9/c31-16-8-6-14(7-9-16)26(34)30-18-13-29-10-2-5-20(18)39-28(37)15-11-19(32)24-22(12-15)38-21-4-1-3-17(27(35)36)23(21)25(24)33/h1,3-4,6-9,11-12,18,20,29,31-32H,2,5,10,13H2,(H,30,34)(H,35,36)/t18-,20-/m1/s1
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n/an/a 1.00E+4n/an/an/an/an/an/a



Sphinx Laboratories



Assay Description
PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.


J Med Chem 45: 2624-43 (2002)


Article DOI: 10.1021/jm020018f
BindingDB Entry DOI: 10.7270/Q2BG2M50
More data for this
Ligand-Target Pair
Protein kinase C alpha type


(Homo sapiens (Human))
BDBM3207
PNG
(10''-Deoxybalanol, 4 | 2-{[2,6-dihydroxy-4-({[(3R,...)
Show SMILES OC(=O)c1ccccc1C(=O)c1c(O)cc(cc1O)C(=O)O[C@@H]1CCCNC[C@H]1NC(=O)c1ccc(O)cc1 |r|
Show InChI InChI=1S/C28H26N2O9/c31-17-9-7-15(8-10-17)26(35)30-20-14-29-11-3-6-23(20)39-28(38)16-12-21(32)24(22(33)13-16)25(34)18-4-1-2-5-19(18)27(36)37/h1-2,4-5,7-10,12-13,20,23,29,31-33H,3,6,11,14H2,(H,30,35)(H,36,37)/t20-,23-/m1/s1
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n/an/a 1.00E+4n/an/an/an/a7.530



Sphinx Laboratories



Assay Description
PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.


J Med Chem 45: 2624-43 (2002)


Article DOI: 10.1021/jm020018f
BindingDB Entry DOI: 10.7270/Q2BG2M50
More data for this
Ligand-Target Pair
Protein kinase C alpha type


(Homo sapiens (Human))
BDBM3241
PNG
((1R,2R)-2-[(4-hydroxybenzene)amido]cyclopentyl 3,5...)
Show SMILES Cn1nnnc1-c1cccc(O)c1C(=O)c1c(O)cc(cc1O)C(=O)O[C@@H]1CCC[C@H]1NC(=O)c1ccc(O)cc1 |r|
Show InChI InChI=1S/C28H25N5O8/c1-33-26(30-31-32-33)17-4-2-6-19(35)23(17)25(38)24-20(36)12-15(13-21(24)37)28(40)41-22-7-3-5-18(22)29-27(39)14-8-10-16(34)11-9-14/h2,4,6,8-13,18,22,34-37H,3,5,7H2,1H3,(H,29,39)/t18-,22-/m1/s1
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n/an/a 1.10E+4n/an/an/an/an/an/a



Sphinx Laboratories



Assay Description
PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.


J Med Chem 45: 2624-43 (2002)


Article DOI: 10.1021/jm020018f
BindingDB Entry DOI: 10.7270/Q2BG2M50
More data for this
Ligand-Target Pair
Protein kinase C beta type


(Homo sapiens (Human))
BDBM3210
PNG
(2-{[2,6-dihydroxy-4-({[(3R,4R)-3-[(4-hydroxybenzen...)
Show SMILES OC(=O)c1cccnc1C(=O)c1c(O)cc(cc1O)C(=O)O[C@@H]1CCCNC[C@H]1NC(=O)c1ccc(O)cc1 |r|
Show InChI InChI=1S/C27H25N3O9/c31-16-7-5-14(6-8-16)25(35)30-18-13-28-9-2-4-21(18)39-27(38)15-11-19(32)22(20(33)12-15)24(34)23-17(26(36)37)3-1-10-29-23/h1,3,5-8,10-12,18,21,28,31-33H,2,4,9,13H2,(H,30,35)(H,36,37)/t18-,21-/m1/s1
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n/an/a 1.30E+4n/an/an/an/a7.530



Sphinx Laboratories



Assay Description
PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.


J Med Chem 45: 2624-43 (2002)


Article DOI: 10.1021/jm020018f
BindingDB Entry DOI: 10.7270/Q2BG2M50
More data for this
Ligand-Target Pair
cAMP-dependent protein kinase catalytic subunit alpha


(Bos taurus (bovine))
BDBM3214
PNG
(4-trans-[(1-Carboxy-8-hydroxy-9-oxoxanthen-6-yl)ca...)
Show SMILES OC(=O)c1cccc2oc3cc(cc(O)c3c(=O)c12)C(=O)O[C@@H]1CCCNC[C@H]1NC(=O)c1ccc(O)cc1 |r|
Show InChI InChI=1S/C28H24N2O9/c31-16-8-6-14(7-9-16)26(34)30-18-13-29-10-2-5-20(18)39-28(37)15-11-19(32)24-22(12-15)38-21-4-1-3-17(27(35)36)23(21)25(24)33/h1,3-4,6-9,11-12,18,20,29,31-32H,2,5,10,13H2,(H,30,34)(H,35,36)/t18-,20-/m1/s1
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n/an/a>1.50E+4n/an/an/an/an/an/a



Sphinx Laboratories



Assay Description
The activity of PKA, activated by cAMP, is measured by its ability to transfer phosphate from [gamma-32P]ATP to histone.


J Med Chem 45: 2624-43 (2002)


Article DOI: 10.1021/jm020018f
BindingDB Entry DOI: 10.7270/Q2BG2M50
More data for this
Ligand-Target Pair
Protein kinase C epsilon type


(Homo sapiens (Human))
BDBM3226
PNG
((3R,4R)-3-[(4-hydroxybenzene)amido]azepan-4-yl 3,5...)
Show SMILES Oc1ccc(cc1)C(=O)N[C@@H]1CNCCC[C@H]1OC(=O)c1cc(O)c(C2OC(=O)c3cccc(O)c23)c(O)c1 |r|
Show InChI InChI=1S/C28H26N2O9/c31-16-8-6-14(7-9-16)26(35)30-18-13-29-10-2-5-22(18)38-27(36)15-11-20(33)24(21(34)12-15)25-23-17(28(37)39-25)3-1-4-19(23)32/h1,3-4,6-9,11-12,18,22,25,29,31-34H,2,5,10,13H2,(H,30,35)/t18-,22-,25?/m1/s1
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n/an/a 1.60E+4n/an/an/an/an/an/a



Sphinx Laboratories



Assay Description
PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.


J Med Chem 45: 2624-43 (2002)


Article DOI: 10.1021/jm020018f
BindingDB Entry DOI: 10.7270/Q2BG2M50
More data for this
Ligand-Target Pair
Protein kinase C alpha type


(Homo sapiens (Human))
BDBM3226
PNG
((3R,4R)-3-[(4-hydroxybenzene)amido]azepan-4-yl 3,5...)
Show SMILES Oc1ccc(cc1)C(=O)N[C@@H]1CNCCC[C@H]1OC(=O)c1cc(O)c(C2OC(=O)c3cccc(O)c23)c(O)c1 |r|
Show InChI InChI=1S/C28H26N2O9/c31-16-8-6-14(7-9-16)26(35)30-18-13-29-10-2-5-22(18)38-27(36)15-11-20(33)24(21(34)12-15)25-23-17(28(37)39-25)3-1-4-19(23)32/h1,3-4,6-9,11-12,18,22,25,29,31-34H,2,5,10,13H2,(H,30,35)/t18-,22-,25?/m1/s1
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n/an/a 1.80E+4n/an/an/an/an/an/a



Sphinx Laboratories



Assay Description
PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.


J Med Chem 45: 2624-43 (2002)


Article DOI: 10.1021/jm020018f
BindingDB Entry DOI: 10.7270/Q2BG2M50
More data for this
Ligand-Target Pair
Protein kinase C beta type


(Homo sapiens (Human))
BDBM3233
PNG
((1R,2R)-2-[(4-hydroxybenzene)amido]cyclopentyl 4-{...)
Show SMILES NCCOc1cccc(O)c1C(=O)c1c(O)cc(cc1O)C(=O)O[C@@H]1CCC[C@H]1NC(=O)c1ccc(O)cc1 |r|
Show InChI InChI=1S/C28H28N2O9/c29-11-12-38-23-6-2-4-19(32)25(23)26(35)24-20(33)13-16(14-21(24)34)28(37)39-22-5-1-3-18(22)30-27(36)15-7-9-17(31)10-8-15/h2,4,6-10,13-14,18,22,31-34H,1,3,5,11-12,29H2,(H,30,36)/t18-,22-/m1/s1
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n/an/a 2.40E+4n/an/an/an/an/an/a



Sphinx Laboratories



Assay Description
PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.


J Med Chem 45: 2624-43 (2002)


Article DOI: 10.1021/jm020018f
BindingDB Entry DOI: 10.7270/Q2BG2M50
More data for this
Ligand-Target Pair
Protein kinase C alpha type


(Homo sapiens (Human))
BDBM3231
PNG
((3R,4R)-3-[(4-hydroxybenzene)amido]azepan-4-yl 3,5...)
Show SMILES COc1cccc(O)c1C(=O)c1c(O)cc(cc1O)C(=O)O[C@@H]1CCCNC[C@H]1NC(=O)c1ccc(O)cc1 |r|
Show InChI InChI=1S/C28H28N2O9/c1-38-23-5-2-4-19(32)25(23)26(35)24-20(33)12-16(13-21(24)34)28(37)39-22-6-3-11-29-14-18(22)30-27(36)15-7-9-17(31)10-8-15/h2,4-5,7-10,12-13,18,22,29,31-34H,3,6,11,14H2,1H3,(H,30,36)/t18-,22-/m1/s1
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n/an/a 2.50E+4n/an/an/an/an/an/a



Sphinx Laboratories



Assay Description
PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.


J Med Chem 45: 2624-43 (2002)


Article DOI: 10.1021/jm020018f
BindingDB Entry DOI: 10.7270/Q2BG2M50
More data for this
Ligand-Target Pair
Protein kinase C beta type


(Homo sapiens (Human))
BDBM3215
PNG
((3R,4R)-4-[(4-hydroxybenzene)amido]pyrrolidin-3-yl...)
Show SMILES Oc1ccc(cc1)C(=O)N[C@@H]1CNC[C@H]1OC(=O)c1cc(O)c2C(=O)c3c(O)cccc3C(=O)c2c1 |r|
Show InChI InChI=1S/C26H20N2O8/c29-14-6-4-12(5-7-14)25(34)28-17-10-27-11-20(17)36-26(35)13-8-16-22(19(31)9-13)24(33)21-15(23(16)32)2-1-3-18(21)30/h1-9,17,20,27,29-31H,10-11H2,(H,28,34)/t17-,20-/m1/s1
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n/an/a 2.50E+4n/an/an/an/an/an/a



Sphinx Laboratories



Assay Description
PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.


J Med Chem 45: 2624-43 (2002)


Article DOI: 10.1021/jm020018f
BindingDB Entry DOI: 10.7270/Q2BG2M50
More data for this
Ligand-Target Pair
Protein kinase C beta type


(Homo sapiens (Human))
BDBM3213
PNG
((3R,4R)-3-[(4-hydroxybenzene)amido]azepan-4-yl 4-[...)
Show SMILES COc1cccc(OC)c1C(=O)c1c(O)cc(cc1O)C(=O)O[C@@H]1CCCNC[C@H]1NC(=O)c1ccc(O)cc1 |r|
Show InChI InChI=1S/C29H30N2O9/c1-38-23-5-3-6-24(39-2)26(23)27(35)25-20(33)13-17(14-21(25)34)29(37)40-22-7-4-12-30-15-19(22)31-28(36)16-8-10-18(32)11-9-16/h3,5-6,8-11,13-14,19,22,30,32-34H,4,7,12,15H2,1-2H3,(H,31,36)/t19-,22-/m1/s1
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n/an/a 2.60E+4n/an/an/an/an/an/a



Sphinx Laboratories



Assay Description
PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.


J Med Chem 45: 2624-43 (2002)


Article DOI: 10.1021/jm020018f
BindingDB Entry DOI: 10.7270/Q2BG2M50
More data for this
Ligand-Target Pair
cAMP-dependent protein kinase catalytic subunit alpha


(Bos taurus (bovine))
BDBM3222
PNG
(2-{[2,6-dihydroxy-4-({[(3R,4R)-4-[(4-hydroxybenzen...)
Show SMILES OC(=O)CN(C(=O)c1c(O)cc(cc1O)C(=O)O[C@@H]1CNC[C@H]1NC(=O)c1ccc(O)cc1)c1ccccc1 |r|
Show InChI InChI=1S/C27H25N3O9/c31-18-8-6-15(7-9-18)25(36)29-19-12-28-13-22(19)39-27(38)16-10-20(32)24(21(33)11-16)26(37)30(14-23(34)35)17-4-2-1-3-5-17/h1-11,19,22,28,31-33H,12-14H2,(H,29,36)(H,34,35)/t19-,22-/m1/s1
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n/an/a 2.90E+4n/an/an/an/an/an/a



Sphinx Laboratories



Assay Description
The activity of PKA, activated by cAMP, is measured by its ability to transfer phosphate from [gamma-32P]ATP to histone.


J Med Chem 45: 2624-43 (2002)


Article DOI: 10.1021/jm020018f
BindingDB Entry DOI: 10.7270/Q2BG2M50
More data for this
Ligand-Target Pair
Protein kinase C epsilon type


(Homo sapiens (Human))
BDBM3217
PNG
(3-hydroxy-2-{[4-({[(1R,2R)-2-[(4-hydroxybenzene)am...)
Show SMILES OC(=O)c1cccc(O)c1C(=O)c1ccc(cc1)C(=O)O[C@@H]1CCC[C@H]1NC(=O)c1ccc(O)cc1 |r|
Show InChI InChI=1S/C27H23NO8/c29-18-13-11-16(12-14-18)25(32)28-20-4-2-6-22(20)36-27(35)17-9-7-15(8-10-17)24(31)23-19(26(33)34)3-1-5-21(23)30/h1,3,5,7-14,20,22,29-30H,2,4,6H2,(H,28,32)(H,33,34)/t20-,22-/m1/s1
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n/an/a 3.00E+4n/an/an/an/an/an/a



Sphinx Laboratories



Assay Description
PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.


J Med Chem 45: 2624-43 (2002)


Article DOI: 10.1021/jm020018f
BindingDB Entry DOI: 10.7270/Q2BG2M50
More data for this
Ligand-Target Pair
Protein kinase C alpha type


(Homo sapiens (Human))
BDBM3213
PNG
((3R,4R)-3-[(4-hydroxybenzene)amido]azepan-4-yl 4-[...)
Show SMILES COc1cccc(OC)c1C(=O)c1c(O)cc(cc1O)C(=O)O[C@@H]1CCCNC[C@H]1NC(=O)c1ccc(O)cc1 |r|
Show InChI InChI=1S/C29H30N2O9/c1-38-23-5-3-6-24(39-2)26(23)27(35)25-20(33)13-17(14-21(25)34)29(37)40-22-7-4-12-30-15-19(22)31-28(36)16-8-10-18(32)11-9-16/h3,5-6,8-11,13-14,19,22,30,32-34H,4,7,12,15H2,1-2H3,(H,31,36)/t19-,22-/m1/s1
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n/an/a 3.10E+4n/an/an/an/an/an/a



Sphinx Laboratories



Assay Description
PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.


J Med Chem 45: 2624-43 (2002)


Article DOI: 10.1021/jm020018f
BindingDB Entry DOI: 10.7270/Q2BG2M50
More data for this
Ligand-Target Pair
Protein kinase C alpha type


(Homo sapiens (Human))
BDBM3217
PNG
(3-hydroxy-2-{[4-({[(1R,2R)-2-[(4-hydroxybenzene)am...)
Show SMILES OC(=O)c1cccc(O)c1C(=O)c1ccc(cc1)C(=O)O[C@@H]1CCC[C@H]1NC(=O)c1ccc(O)cc1 |r|
Show InChI InChI=1S/C27H23NO8/c29-18-13-11-16(12-14-18)25(32)28-20-4-2-6-22(20)36-27(35)17-9-7-15(8-10-17)24(31)23-19(26(33)34)3-1-5-21(23)30/h1,3,5,7-14,20,22,29-30H,2,4,6H2,(H,28,32)(H,33,34)/t20-,22-/m1/s1
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n/an/a 3.40E+4n/an/an/an/an/an/a



Sphinx Laboratories



Assay Description
PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.


J Med Chem 45: 2624-43 (2002)


Article DOI: 10.1021/jm020018f
BindingDB Entry DOI: 10.7270/Q2BG2M50
More data for this
Ligand-Target Pair
Protein kinase C epsilon type


(Homo sapiens (Human))
BDBM3219
PNG
((3R,4R)-3-[(4-hydroxybenzene)amido]azepan-4-yl 4-[...)
Show SMILES COc1cc(cc(OC)c1C(=O)c1c(O)cccc1O)C(=O)O[C@@H]1CCCNC[C@H]1NC(=O)c1ccc(O)cc1 |r|
Show InChI InChI=1S/C29H30N2O9/c1-38-23-13-17(14-24(39-2)26(23)27(35)25-20(33)5-3-6-21(25)34)29(37)40-22-7-4-12-30-15-19(22)31-28(36)16-8-10-18(32)11-9-16/h3,5-6,8-11,13-14,19,22,30,32-34H,4,7,12,15H2,1-2H3,(H,31,36)/t19-,22-/m1/s1
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n/an/a 3.60E+4n/an/an/an/an/an/a



Sphinx Laboratories



Assay Description
PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.


J Med Chem 45: 2624-43 (2002)


Article DOI: 10.1021/jm020018f
BindingDB Entry DOI: 10.7270/Q2BG2M50
More data for this
Ligand-Target Pair
Protein kinase C alpha type


(Homo sapiens (Human))
BDBM3210
PNG
(2-{[2,6-dihydroxy-4-({[(3R,4R)-3-[(4-hydroxybenzen...)
Show SMILES OC(=O)c1cccnc1C(=O)c1c(O)cc(cc1O)C(=O)O[C@@H]1CCCNC[C@H]1NC(=O)c1ccc(O)cc1 |r|
Show InChI InChI=1S/C27H25N3O9/c31-16-7-5-14(6-8-16)25(35)30-18-13-28-9-2-4-21(18)39-27(38)15-11-19(32)22(20(33)12-15)24(34)23-17(26(36)37)3-1-10-29-23/h1,3,5-8,10-12,18,21,28,31-33H,2,4,9,13H2,(H,30,35)(H,36,37)/t18-,21-/m1/s1
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n/an/a 3.70E+4n/an/an/an/a7.530



Sphinx Laboratories



Assay Description
PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.


J Med Chem 45: 2624-43 (2002)


Article DOI: 10.1021/jm020018f
BindingDB Entry DOI: 10.7270/Q2BG2M50
More data for this
Ligand-Target Pair
Protein kinase C beta type


(Homo sapiens (Human))
BDBM3211
PNG
((3R,4R)-3-[(4-hydroxybenzene)amido]azepan-4-yl 3,5...)
Show SMILES Oc1ccc(cc1)C(=O)N[C@@H]1CNCCC[C@H]1OC(=O)c1cc(O)c(C(=O)c2ccccc2O)c(O)c1 |r|
Show InChI InChI=1S/C27H26N2O8/c30-17-9-7-15(8-10-17)26(35)29-19-14-28-11-3-6-23(19)37-27(36)16-12-21(32)24(22(33)13-16)25(34)18-4-1-2-5-20(18)31/h1-2,4-5,7-10,12-13,19,23,28,30-33H,3,6,11,14H2,(H,29,35)/t19-,23-/m1/s1
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n/an/a 3.80E+4n/an/an/an/a7.530



Sphinx Laboratories



Assay Description
PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.


J Med Chem 45: 2624-43 (2002)


Article DOI: 10.1021/jm020018f
BindingDB Entry DOI: 10.7270/Q2BG2M50
More data for this
Ligand-Target Pair
Protein kinase C epsilon type


(Homo sapiens (Human))
BDBM3221
PNG
(2-{[2,6-dihydroxy-4-({[(3R,4R)-4-[(4-hydroxybenzen...)
Show SMILES OC(=O)c1ccccc1NC(=O)c1c(O)cc(cc1O)C(=O)O[C@@H]1CNC[C@H]1NC(=O)c1ccc(O)cc1 |r|
Show InChI InChI=1S/C26H23N3O9/c30-15-7-5-13(6-8-15)23(33)29-18-11-27-12-21(18)38-26(37)14-9-19(31)22(20(32)10-14)24(34)28-17-4-2-1-3-16(17)25(35)36/h1-10,18,21,27,30-32H,11-12H2,(H,28,34)(H,29,33)(H,35,36)/t18-,21-/m1/s1
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n/an/a 3.90E+4n/an/an/an/an/an/a



Sphinx Laboratories



Assay Description
PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.


J Med Chem 45: 2624-43 (2002)


Article DOI: 10.1021/jm020018f
BindingDB Entry DOI: 10.7270/Q2BG2M50
More data for this
Ligand-Target Pair
Protein kinase C beta type


(Homo sapiens (Human))
BDBM3224
PNG
(3-hydroxy-2-[4-({[(3R,4R)-4-[(4-hydroxybenzene)ami...)
Show SMILES OC(=O)c1cccc(O)c1-c1ccc(cc1)C(=O)O[C@@H]1CNC[C@H]1NC(=O)c1ccc(O)cc1 |r|
Show InChI InChI=1S/C25H22N2O7/c28-17-10-8-15(9-11-17)23(30)27-19-12-26-13-21(19)34-25(33)16-6-4-14(5-7-16)22-18(24(31)32)2-1-3-20(22)29/h1-11,19,21,26,28-29H,12-13H2,(H,27,30)(H,31,32)/t19-,21-/m1/s1
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n/an/a 4.00E+4n/an/an/an/an/an/a



Sphinx Laboratories



Assay Description
PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.


J Med Chem 45: 2624-43 (2002)


Article DOI: 10.1021/jm020018f
BindingDB Entry DOI: 10.7270/Q2BG2M50
More data for this
Ligand-Target Pair
Protein kinase C alpha type


(Homo sapiens (Human))
BDBM3215
PNG
((3R,4R)-4-[(4-hydroxybenzene)amido]pyrrolidin-3-yl...)
Show SMILES Oc1ccc(cc1)C(=O)N[C@@H]1CNC[C@H]1OC(=O)c1cc(O)c2C(=O)c3c(O)cccc3C(=O)c2c1 |r|
Show InChI InChI=1S/C26H20N2O8/c29-14-6-4-12(5-7-14)25(34)28-17-10-27-11-20(17)36-26(35)13-8-16-22(19(31)9-13)24(33)21-15(23(16)32)2-1-3-18(21)30/h1-9,17,20,27,29-31H,10-11H2,(H,28,34)/t17-,20-/m1/s1
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n/an/a 4.30E+4n/an/an/an/an/an/a



Sphinx Laboratories



Assay Description
PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.


J Med Chem 45: 2624-43 (2002)


Article DOI: 10.1021/jm020018f
BindingDB Entry DOI: 10.7270/Q2BG2M50
More data for this
Ligand-Target Pair
Protein kinase C epsilon type


(Homo sapiens (Human))
BDBM3209
PNG
((1R,2R)-2-{[2,6-dihydroxy-4-({[(3R,4R)-3-[(4-hydro...)
Show SMILES OC(=O)[C@@H]1CCCC[C@H]1C(=O)c1c(O)cc(cc1O)C(=O)O[C@@H]1CCCNC[C@H]1NC(=O)c1ccc(O)cc1 |r|
Show InChI InChI=1S/C28H32N2O9/c31-17-9-7-15(8-10-17)26(35)30-20-14-29-11-3-6-23(20)39-28(38)16-12-21(32)24(22(33)13-16)25(34)18-4-1-2-5-19(18)27(36)37/h7-10,12-13,18-20,23,29,31-33H,1-6,11,14H2,(H,30,35)(H,36,37)/t18-,19-,20-,23-/m1/s1
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n/an/a 4.70E+4n/an/an/an/a7.530



Sphinx Laboratories



Assay Description
PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.


J Med Chem 45: 2624-43 (2002)


Article DOI: 10.1021/jm020018f
BindingDB Entry DOI: 10.7270/Q2BG2M50
More data for this
Ligand-Target Pair
Protein kinase C epsilon type


(Homo sapiens (Human))
BDBM3218
PNG
((-)-(1R,2R)-1-[4-(2-Carboxy-6-hydroxybenzoyl)-3,5-...)
Show SMILES Cc1cc(cc(C)c1C(=O)c1c(O)cccc1C(O)=O)C(=O)O[C@@H]1CCC[C@H]1NC(=O)c1ccc(O)cc1 |r|
Show InChI InChI=1S/C29H27NO8/c1-15-13-18(14-16(2)24(15)26(33)25-20(28(35)36)5-3-7-22(25)32)29(37)38-23-8-4-6-21(23)30-27(34)17-9-11-19(31)12-10-17/h3,5,7,9-14,21,23,31-32H,4,6,8H2,1-2H3,(H,30,34)(H,35,36)/t21-,23-/m1/s1
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n/an/a>5.00E+4n/an/an/an/an/an/a



Sphinx Laboratories



Assay Description
PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.


J Med Chem 45: 2624-43 (2002)


Article DOI: 10.1021/jm020018f
BindingDB Entry DOI: 10.7270/Q2BG2M50
More data for this
Ligand-Target Pair
Protein kinase C alpha type


(Homo sapiens (Human))
BDBM3224
PNG
(3-hydroxy-2-[4-({[(3R,4R)-4-[(4-hydroxybenzene)ami...)
Show SMILES OC(=O)c1cccc(O)c1-c1ccc(cc1)C(=O)O[C@@H]1CNC[C@H]1NC(=O)c1ccc(O)cc1 |r|
Show InChI InChI=1S/C25H22N2O7/c28-17-10-8-15(9-11-17)23(30)27-19-12-26-13-21(19)34-25(33)16-6-4-14(5-7-16)22-18(24(31)32)2-1-3-20(22)29/h1-11,19,21,26,28-29H,12-13H2,(H,27,30)(H,31,32)/t19-,21-/m1/s1
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n/an/a>5.00E+4n/an/an/an/an/an/a



Sphinx Laboratories



Assay Description
PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.


J Med Chem 45: 2624-43 (2002)


Article DOI: 10.1021/jm020018f
BindingDB Entry DOI: 10.7270/Q2BG2M50
More data for this
Ligand-Target Pair
Protein kinase C epsilon type


(Homo sapiens (Human))
BDBM3224
PNG
(3-hydroxy-2-[4-({[(3R,4R)-4-[(4-hydroxybenzene)ami...)
Show SMILES OC(=O)c1cccc(O)c1-c1ccc(cc1)C(=O)O[C@@H]1CNC[C@H]1NC(=O)c1ccc(O)cc1 |r|
Show InChI InChI=1S/C25H22N2O7/c28-17-10-8-15(9-11-17)23(30)27-19-12-26-13-21(19)34-25(33)16-6-4-14(5-7-16)22-18(24(31)32)2-1-3-20(22)29/h1-11,19,21,26,28-29H,12-13H2,(H,27,30)(H,31,32)/t19-,21-/m1/s1
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n/an/a>5.00E+4n/an/an/an/an/an/a



Sphinx Laboratories



Assay Description
PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.


J Med Chem 45: 2624-43 (2002)


Article DOI: 10.1021/jm020018f
BindingDB Entry DOI: 10.7270/Q2BG2M50
More data for this
Ligand-Target Pair
Protein kinase C beta type


(Homo sapiens (Human))
BDBM3218
PNG
((-)-(1R,2R)-1-[4-(2-Carboxy-6-hydroxybenzoyl)-3,5-...)
Show SMILES Cc1cc(cc(C)c1C(=O)c1c(O)cccc1C(O)=O)C(=O)O[C@@H]1CCC[C@H]1NC(=O)c1ccc(O)cc1 |r|
Show InChI InChI=1S/C29H27NO8/c1-15-13-18(14-16(2)24(15)26(33)25-20(28(35)36)5-3-7-22(25)32)29(37)38-23-8-4-6-21(23)30-27(34)17-9-11-19(31)12-10-17/h3,5,7,9-14,21,23,31-32H,4,6,8H2,1-2H3,(H,30,34)(H,35,36)/t21-,23-/m1/s1
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n/an/a>5.00E+4n/an/an/an/an/an/a



Sphinx Laboratories



Assay Description
PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.


J Med Chem 45: 2624-43 (2002)


Article DOI: 10.1021/jm020018f
BindingDB Entry DOI: 10.7270/Q2BG2M50
More data for this
Ligand-Target Pair
Protein kinase C epsilon type


(Homo sapiens (Human))
BDBM3242
PNG
((1R,2R)-2-[(4-hydroxybenzene)amido]cyclopentyl 3,5...)
Show SMILES Oc1ccc(cc1)C(=O)N[C@@H]1CCC[C@H]1OC(=O)c1cc(O)c(c(O)c1)-c1n[nH]c(=O)c2cccc(O)c12 |r,wU:14.16,wD:10.10,(17.01,-18.03,;15.69,-18.03,;14.92,-16.69,;13.38,-16.69,;12.61,-18.03,;13.38,-19.36,;14.92,-19.36,;11.01,-18.04,;10.33,-19.36,;10.22,-16.71,;8.89,-16.04,;7.43,-16.52,;6.52,-15.27,;7.43,-14.03,;8.89,-14.5,;10,-13.77,;11.63,-13.78,;12.2,-14.92,;12.37,-12.54,;11.6,-11.2,;12.37,-9.87,;11.69,-8.45,;13.91,-9.87,;14.68,-11.2,;16.15,-11.21,;13.91,-12.54,;14.58,-8.54,;13.25,-7.77,;13.25,-6.23,;14.58,-5.46,;14.58,-4.03,;15.91,-6.23,;17.25,-5.46,;18.58,-6.23,;18.58,-7.77,;17.25,-8.54,;17.23,-9.96,;15.91,-7.77,)|
Show InChI InChI=1S/C27H23N3O8/c31-15-9-7-13(8-10-15)25(35)28-17-4-2-6-21(17)38-27(37)14-11-19(33)23(20(34)12-14)24-22-16(26(36)30-29-24)3-1-5-18(22)32/h1,3,5,7-12,17,21,31-34H,2,4,6H2,(H,28,35)(H,30,36)/t17-,21-/m1/s1
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n/an/a>5.00E+4n/an/an/an/an/an/a



Sphinx Laboratories



Assay Description
PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.


J Med Chem 45: 2624-43 (2002)


Article DOI: 10.1021/jm020018f
BindingDB Entry DOI: 10.7270/Q2BG2M50
More data for this
Ligand-Target Pair
Protein kinase C alpha type


(Homo sapiens (Human))
BDBM3242
PNG
((1R,2R)-2-[(4-hydroxybenzene)amido]cyclopentyl 3,5...)
Show SMILES Oc1ccc(cc1)C(=O)N[C@@H]1CCC[C@H]1OC(=O)c1cc(O)c(c(O)c1)-c1n[nH]c(=O)c2cccc(O)c12 |r,wU:14.16,wD:10.10,(17.01,-18.03,;15.69,-18.03,;14.92,-16.69,;13.38,-16.69,;12.61,-18.03,;13.38,-19.36,;14.92,-19.36,;11.01,-18.04,;10.33,-19.36,;10.22,-16.71,;8.89,-16.04,;7.43,-16.52,;6.52,-15.27,;7.43,-14.03,;8.89,-14.5,;10,-13.77,;11.63,-13.78,;12.2,-14.92,;12.37,-12.54,;11.6,-11.2,;12.37,-9.87,;11.69,-8.45,;13.91,-9.87,;14.68,-11.2,;16.15,-11.21,;13.91,-12.54,;14.58,-8.54,;13.25,-7.77,;13.25,-6.23,;14.58,-5.46,;14.58,-4.03,;15.91,-6.23,;17.25,-5.46,;18.58,-6.23,;18.58,-7.77,;17.25,-8.54,;17.23,-9.96,;15.91,-7.77,)|
Show InChI InChI=1S/C27H23N3O8/c31-15-9-7-13(8-10-15)25(35)28-17-4-2-6-21(17)38-27(37)14-11-19(33)23(20(34)12-14)24-22-16(26(36)30-29-24)3-1-5-18(22)32/h1,3,5,7-12,17,21,31-34H,2,4,6H2,(H,28,35)(H,30,36)/t17-,21-/m1/s1
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n/an/a>5.00E+4n/an/an/an/an/an/a



Sphinx Laboratories



Assay Description
PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.


J Med Chem 45: 2624-43 (2002)


Article DOI: 10.1021/jm020018f
BindingDB Entry DOI: 10.7270/Q2BG2M50
More data for this
Ligand-Target Pair
Protein kinase C alpha type


(Homo sapiens (Human))
BDBM3237
PNG
((1R,2R)-2-[(4-hydroxybenzene)amido]cyclopentyl 3,5...)
Show SMILES Oc1ccc(cc1)C(=O)N[C@@H]1CCC[C@H]1OC(=O)c1cc(O)c(C(=O)c2c(O)cccc2NC(=O)C(F)(F)F)c(O)c1 |r|
Show InChI InChI=1S/C28H23F3N2O9/c29-28(30,31)27(41)33-17-4-1-5-18(35)22(17)24(38)23-19(36)11-14(12-20(23)37)26(40)42-21-6-2-3-16(21)32-25(39)13-7-9-15(34)10-8-13/h1,4-5,7-12,16,21,34-37H,2-3,6H2,(H,32,39)(H,33,41)/t16-,21-/m1/s1
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n/an/a>5.00E+4n/an/an/an/an/an/a



Sphinx Laboratories



Assay Description
PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.


J Med Chem 45: 2624-43 (2002)


Article DOI: 10.1021/jm020018f
BindingDB Entry DOI: 10.7270/Q2BG2M50
More data for this
Ligand-Target Pair
Protein kinase C beta type


(Homo sapiens (Human))
BDBM3223
PNG
(2-[2,6-dihydroxy-4-({[(3R,4R)-4-[(4-hydroxybenzene...)
Show SMILES OC(=O)c1ccccc1-c1c(O)cc(cc1O)C(=O)O[C@@H]1CNC[C@H]1NC(=O)c1ccc(O)cc1 |r,wU:20.21,wD:24.27,(13.02,-5.22,;14.53,-5.22,;14.9,-3.9,;16.02,-6.07,;17.35,-5.3,;18.68,-6.07,;18.68,-7.61,;17.35,-8.38,;16.02,-7.61,;14.83,-9.27,;13.29,-9.27,;12.61,-7.85,;12.52,-10.6,;13.29,-11.94,;14.83,-11.94,;15.6,-10.6,;17.07,-10.6,;12.55,-13.18,;13.24,-14.3,;10.93,-13.17,;9.82,-13.9,;8.35,-13.42,;7.45,-14.67,;8.35,-15.92,;9.82,-15.44,;11.15,-16.1,;11.94,-17.44,;11.25,-18.76,;13.54,-17.42,;14.31,-16.09,;15.85,-16.09,;16.62,-17.42,;17.94,-17.42,;15.85,-18.76,;14.31,-18.76,)|
Show InChI InChI=1S/C25H22N2O8/c28-15-7-5-13(6-8-15)23(31)27-18-11-26-12-21(18)35-25(34)14-9-19(29)22(20(30)10-14)16-3-1-2-4-17(16)24(32)33/h1-10,18,21,26,28-30H,11-12H2,(H,27,31)(H,32,33)/t18-,21-/m1/s1
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n/an/a>5.00E+4n/an/an/an/an/an/a



Sphinx Laboratories



Assay Description
PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.


J Med Chem 45: 2624-43 (2002)


Article DOI: 10.1021/jm020018f
BindingDB Entry DOI: 10.7270/Q2BG2M50
More data for this
Ligand-Target Pair
Protein kinase C alpha type


(Homo sapiens (Human))
BDBM3223
PNG
(2-[2,6-dihydroxy-4-({[(3R,4R)-4-[(4-hydroxybenzene...)
Show SMILES OC(=O)c1ccccc1-c1c(O)cc(cc1O)C(=O)O[C@@H]1CNC[C@H]1NC(=O)c1ccc(O)cc1 |r,wU:20.21,wD:24.27,(13.02,-5.22,;14.53,-5.22,;14.9,-3.9,;16.02,-6.07,;17.35,-5.3,;18.68,-6.07,;18.68,-7.61,;17.35,-8.38,;16.02,-7.61,;14.83,-9.27,;13.29,-9.27,;12.61,-7.85,;12.52,-10.6,;13.29,-11.94,;14.83,-11.94,;15.6,-10.6,;17.07,-10.6,;12.55,-13.18,;13.24,-14.3,;10.93,-13.17,;9.82,-13.9,;8.35,-13.42,;7.45,-14.67,;8.35,-15.92,;9.82,-15.44,;11.15,-16.1,;11.94,-17.44,;11.25,-18.76,;13.54,-17.42,;14.31,-16.09,;15.85,-16.09,;16.62,-17.42,;17.94,-17.42,;15.85,-18.76,;14.31,-18.76,)|
Show InChI InChI=1S/C25H22N2O8/c28-15-7-5-13(6-8-15)23(31)27-18-11-26-12-21(18)35-25(34)14-9-19(29)22(20(30)10-14)16-3-1-2-4-17(16)24(32)33/h1-10,18,21,26,28-30H,11-12H2,(H,27,31)(H,32,33)/t18-,21-/m1/s1
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Sphinx Laboratories



Assay Description
PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.


J Med Chem 45: 2624-43 (2002)


Article DOI: 10.1021/jm020018f
BindingDB Entry DOI: 10.7270/Q2BG2M50
More data for this
Ligand-Target Pair
Protein kinase C alpha type


(Homo sapiens (Human))
BDBM3218
PNG
((-)-(1R,2R)-1-[4-(2-Carboxy-6-hydroxybenzoyl)-3,5-...)
Show SMILES Cc1cc(cc(C)c1C(=O)c1c(O)cccc1C(O)=O)C(=O)O[C@@H]1CCC[C@H]1NC(=O)c1ccc(O)cc1 |r|
Show InChI InChI=1S/C29H27NO8/c1-15-13-18(14-16(2)24(15)26(33)25-20(28(35)36)5-3-7-22(25)32)29(37)38-23-8-4-6-21(23)30-27(34)17-9-11-19(31)12-10-17/h3,5,7,9-14,21,23,31-32H,4,6,8H2,1-2H3,(H,30,34)(H,35,36)/t21-,23-/m1/s1
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n/an/a>5.00E+4n/an/an/an/an/an/a



Sphinx Laboratories



Assay Description
PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.


J Med Chem 45: 2624-43 (2002)


Article DOI: 10.1021/jm020018f
BindingDB Entry DOI: 10.7270/Q2BG2M50
More data for this
Ligand-Target Pair
Protein kinase C beta type


(Homo sapiens (Human))
BDBM3242
PNG
((1R,2R)-2-[(4-hydroxybenzene)amido]cyclopentyl 3,5...)
Show SMILES Oc1ccc(cc1)C(=O)N[C@@H]1CCC[C@H]1OC(=O)c1cc(O)c(c(O)c1)-c1n[nH]c(=O)c2cccc(O)c12 |r,wU:14.16,wD:10.10,(17.01,-18.03,;15.69,-18.03,;14.92,-16.69,;13.38,-16.69,;12.61,-18.03,;13.38,-19.36,;14.92,-19.36,;11.01,-18.04,;10.33,-19.36,;10.22,-16.71,;8.89,-16.04,;7.43,-16.52,;6.52,-15.27,;7.43,-14.03,;8.89,-14.5,;10,-13.77,;11.63,-13.78,;12.2,-14.92,;12.37,-12.54,;11.6,-11.2,;12.37,-9.87,;11.69,-8.45,;13.91,-9.87,;14.68,-11.2,;16.15,-11.21,;13.91,-12.54,;14.58,-8.54,;13.25,-7.77,;13.25,-6.23,;14.58,-5.46,;14.58,-4.03,;15.91,-6.23,;17.25,-5.46,;18.58,-6.23,;18.58,-7.77,;17.25,-8.54,;17.23,-9.96,;15.91,-7.77,)|
Show InChI InChI=1S/C27H23N3O8/c31-15-9-7-13(8-10-15)25(35)28-17-4-2-6-21(17)38-27(37)14-11-19(33)23(20(34)12-14)24-22-16(26(36)30-29-24)3-1-5-18(22)32/h1,3,5,7-12,17,21,31-34H,2,4,6H2,(H,28,35)(H,30,36)/t17-,21-/m1/s1
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Sphinx Laboratories



Assay Description
PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.


J Med Chem 45: 2624-43 (2002)


Article DOI: 10.1021/jm020018f
BindingDB Entry DOI: 10.7270/Q2BG2M50
More data for this
Ligand-Target Pair
Protein kinase C beta type


(Homo sapiens (Human))
BDBM3237
PNG
((1R,2R)-2-[(4-hydroxybenzene)amido]cyclopentyl 3,5...)
Show SMILES Oc1ccc(cc1)C(=O)N[C@@H]1CCC[C@H]1OC(=O)c1cc(O)c(C(=O)c2c(O)cccc2NC(=O)C(F)(F)F)c(O)c1 |r|
Show InChI InChI=1S/C28H23F3N2O9/c29-28(30,31)27(41)33-17-4-1-5-18(35)22(17)24(38)23-19(36)11-14(12-20(23)37)26(40)42-21-6-2-3-16(21)32-25(39)13-7-9-15(34)10-8-13/h1,4-5,7-12,16,21,34-37H,2-3,6H2,(H,32,39)(H,33,41)/t16-,21-/m1/s1
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n/an/a>5.00E+4n/an/an/an/an/an/a



Sphinx Laboratories



Assay Description
PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.


J Med Chem 45: 2624-43 (2002)


Article DOI: 10.1021/jm020018f
BindingDB Entry DOI: 10.7270/Q2BG2M50
More data for this
Ligand-Target Pair
Protein kinase C alpha type


(Homo sapiens (Human))
BDBM3238
PNG
((1R,2R)-2-[(4-hydroxybenzene)amido]cyclopentyl 4-[...)
Show SMILES CC(=O)Nc1cccc(O)c1C(=O)c1c(O)cc(cc1O)C(=O)O[C@@H]1CCC[C@H]1NC(=O)c1ccc(O)cc1 |r|
Show InChI InChI=1S/C28H26N2O9/c1-14(31)29-19-5-2-6-20(33)24(19)26(36)25-21(34)12-16(13-22(25)35)28(38)39-23-7-3-4-18(23)30-27(37)15-8-10-17(32)11-9-15/h2,5-6,8-13,18,23,32-35H,3-4,7H2,1H3,(H,29,31)(H,30,37)/t18-,23-/m1/s1
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n/an/a>5.00E+4n/an/an/an/an/an/a



Sphinx Laboratories



Assay Description
PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.


J Med Chem 45: 2624-43 (2002)


Article DOI: 10.1021/jm020018f
BindingDB Entry DOI: 10.7270/Q2BG2M50
More data for this
Ligand-Target Pair
Protein kinase C alpha type


(Homo sapiens (Human))
BDBM3233
PNG
((1R,2R)-2-[(4-hydroxybenzene)amido]cyclopentyl 4-{...)
Show SMILES NCCOc1cccc(O)c1C(=O)c1c(O)cc(cc1O)C(=O)O[C@@H]1CCC[C@H]1NC(=O)c1ccc(O)cc1 |r|
Show InChI InChI=1S/C28H28N2O9/c29-11-12-38-23-6-2-4-19(32)25(23)26(35)24-20(33)13-16(14-21(24)34)28(37)39-22-5-1-3-18(22)30-27(36)15-7-9-17(31)10-8-15/h2,4,6-10,13-14,18,22,31-34H,1,3,5,11-12,29H2,(H,30,36)/t18-,22-/m1/s1
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n/an/a>5.00E+4n/an/an/an/an/an/a



Sphinx Laboratories



Assay Description
PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.


J Med Chem 45: 2624-43 (2002)


Article DOI: 10.1021/jm020018f
BindingDB Entry DOI: 10.7270/Q2BG2M50
More data for this
Ligand-Target Pair
Protein kinase C epsilon type


(Homo sapiens (Human))
BDBM3208
PNG
((1S,2R)-2-{[2,6-dihydroxy-4-({[(3R,4R)-3-[(4-hydro...)
Show SMILES OC(=O)[C@H]1CCCC[C@H]1C(=O)c1c(O)cc(cc1O)C(=O)O[C@@H]1CCCNC[C@H]1NC(=O)c1ccc(O)cc1 |r|
Show InChI InChI=1S/C28H32N2O9/c31-17-9-7-15(8-10-17)26(35)30-20-14-29-11-3-6-23(20)39-28(38)16-12-21(32)24(22(33)13-16)25(34)18-4-1-2-5-19(18)27(36)37/h7-10,12-13,18-20,23,29,31-33H,1-6,11,14H2,(H,30,35)(H,36,37)/t18-,19+,20-,23-/m1/s1
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n/an/a 9.70E+4n/an/an/an/a7.530



Sphinx Laboratories



Assay Description
PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.


J Med Chem 45: 2624-43 (2002)


Article DOI: 10.1021/jm020018f
BindingDB Entry DOI: 10.7270/Q2BG2M50
More data for this
Ligand-Target Pair
Protein kinase C alpha type


(Homo sapiens (Human))
BDBM3211
PNG
((3R,4R)-3-[(4-hydroxybenzene)amido]azepan-4-yl 3,5...)
Show SMILES Oc1ccc(cc1)C(=O)N[C@@H]1CNCCC[C@H]1OC(=O)c1cc(O)c(C(=O)c2ccccc2O)c(O)c1 |r|
Show InChI InChI=1S/C27H26N2O8/c30-17-9-7-15(8-10-17)26(35)29-19-14-28-11-3-6-23(19)37-27(36)16-12-21(32)24(22(33)13-16)25(34)18-4-1-2-5-20(18)31/h1-2,4-5,7-10,12-13,19,23,28,30-33H,3,6,11,14H2,(H,29,35)/t19-,23-/m1/s1
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n/an/a 9.70E+4n/an/an/an/a7.530



Sphinx Laboratories



Assay Description
PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.


J Med Chem 45: 2624-43 (2002)


Article DOI: 10.1021/jm020018f
BindingDB Entry DOI: 10.7270/Q2BG2M50
More data for this
Ligand-Target Pair
Protein kinase C beta type


(Homo sapiens (Human))
BDBM3221
PNG
(2-{[2,6-dihydroxy-4-({[(3R,4R)-4-[(4-hydroxybenzen...)
Show SMILES OC(=O)c1ccccc1NC(=O)c1c(O)cc(cc1O)C(=O)O[C@@H]1CNC[C@H]1NC(=O)c1ccc(O)cc1 |r|
Show InChI InChI=1S/C26H23N3O9/c30-15-7-5-13(6-8-15)23(33)29-18-11-27-12-21(18)38-26(37)14-9-19(31)22(20(32)10-14)24(34)28-17-4-2-1-3-16(17)25(35)36/h1-10,18,21,27,30-32H,11-12H2,(H,28,34)(H,29,33)(H,35,36)/t18-,21-/m1/s1
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n/an/a 1.17E+5n/an/an/an/an/an/a



Sphinx Laboratories



Assay Description
PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.


J Med Chem 45: 2624-43 (2002)


Article DOI: 10.1021/jm020018f
BindingDB Entry DOI: 10.7270/Q2BG2M50
More data for this
Ligand-Target Pair
Protein kinase C beta type


(Homo sapiens (Human))
BDBM3208
PNG
((1S,2R)-2-{[2,6-dihydroxy-4-({[(3R,4R)-3-[(4-hydro...)
Show SMILES OC(=O)[C@H]1CCCC[C@H]1C(=O)c1c(O)cc(cc1O)C(=O)O[C@@H]1CCCNC[C@H]1NC(=O)c1ccc(O)cc1 |r|
Show InChI InChI=1S/C28H32N2O9/c31-17-9-7-15(8-10-17)26(35)30-20-14-29-11-3-6-23(20)39-28(38)16-12-21(32)24(22(33)13-16)25(34)18-4-1-2-5-19(18)27(36)37/h7-10,12-13,18-20,23,29,31-33H,1-6,11,14H2,(H,30,35)(H,36,37)/t18-,19+,20-,23-/m1/s1
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n/an/a 1.24E+5n/an/an/an/a7.530



Sphinx Laboratories



Assay Description
PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.


J Med Chem 45: 2624-43 (2002)


Article DOI: 10.1021/jm020018f
BindingDB Entry DOI: 10.7270/Q2BG2M50
More data for this
Ligand-Target Pair
Protein kinase C epsilon type


(Homo sapiens (Human))
BDBM3229
PNG
((3R,4R)-3-[(4-hydroxybenzene)amido]azepan-4-yl 3,5...)
Show SMILES Oc1ccc(cc1)C(=O)N[C@@H]1CNCCC[C@H]1OC(=O)c1cc(O)c(C(=O)c2ccc3ccccc3c2O)c(O)c1 |r|
Show InChI InChI=1S/C31H28N2O8/c34-20-10-7-18(8-11-20)30(39)33-23-16-32-13-3-6-26(23)41-31(40)19-14-24(35)27(25(36)15-19)29(38)22-12-9-17-4-1-2-5-21(17)28(22)37/h1-2,4-5,7-12,14-15,23,26,32,34-37H,3,6,13,16H2,(H,33,39)/t23-,26-/m1/s1
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n/an/a>1.50E+5n/an/an/an/an/an/a



Sphinx Laboratories



Assay Description
PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.


J Med Chem 45: 2624-43 (2002)


Article DOI: 10.1021/jm020018f
BindingDB Entry DOI: 10.7270/Q2BG2M50
More data for this
Ligand-Target Pair
Protein kinase C alpha type


(Homo sapiens (Human))
BDBM3208
PNG
((1S,2R)-2-{[2,6-dihydroxy-4-({[(3R,4R)-3-[(4-hydro...)
Show SMILES OC(=O)[C@H]1CCCC[C@H]1C(=O)c1c(O)cc(cc1O)C(=O)O[C@@H]1CCCNC[C@H]1NC(=O)c1ccc(O)cc1 |r|
Show InChI InChI=1S/C28H32N2O9/c31-17-9-7-15(8-10-17)26(35)30-20-14-29-11-3-6-23(20)39-28(38)16-12-21(32)24(22(33)13-16)25(34)18-4-1-2-5-19(18)27(36)37/h7-10,12-13,18-20,23,29,31-33H,1-6,11,14H2,(H,30,35)(H,36,37)/t18-,19+,20-,23-/m1/s1
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n/an/a>1.50E+5n/an/an/an/a7.530



Sphinx Laboratories



Assay Description
PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.


J Med Chem 45: 2624-43 (2002)


Article DOI: 10.1021/jm020018f
BindingDB Entry DOI: 10.7270/Q2BG2M50
More data for this
Ligand-Target Pair
Protein kinase C alpha type


(Homo sapiens (Human))
BDBM3214
PNG
(4-trans-[(1-Carboxy-8-hydroxy-9-oxoxanthen-6-yl)ca...)
Show SMILES OC(=O)c1cccc2oc3cc(cc(O)c3c(=O)c12)C(=O)O[C@@H]1CCCNC[C@H]1NC(=O)c1ccc(O)cc1 |r|
Show InChI InChI=1S/C28H24N2O9/c31-16-8-6-14(7-9-16)26(34)30-18-13-29-10-2-5-20(18)39-28(37)15-11-19(32)24-22(12-15)38-21-4-1-3-17(27(35)36)23(21)25(24)33/h1,3-4,6-9,11-12,18,20,29,31-32H,2,5,10,13H2,(H,30,34)(H,35,36)/t18-,20-/m1/s1
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n/an/a>1.50E+5n/an/an/an/an/an/a



Sphinx Laboratories



Assay Description
PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.


J Med Chem 45: 2624-43 (2002)


Article DOI: 10.1021/jm020018f
BindingDB Entry DOI: 10.7270/Q2BG2M50
More data for this
Ligand-Target Pair
Protein kinase C alpha type


(Homo sapiens (Human))
BDBM3209
PNG
((1R,2R)-2-{[2,6-dihydroxy-4-({[(3R,4R)-3-[(4-hydro...)
Show SMILES OC(=O)[C@@H]1CCCC[C@H]1C(=O)c1c(O)cc(cc1O)C(=O)O[C@@H]1CCCNC[C@H]1NC(=O)c1ccc(O)cc1 |r|
Show InChI InChI=1S/C28H32N2O9/c31-17-9-7-15(8-10-17)26(35)30-20-14-29-11-3-6-23(20)39-28(38)16-12-21(32)24(22(33)13-16)25(34)18-4-1-2-5-19(18)27(36)37/h7-10,12-13,18-20,23,29,31-33H,1-6,11,14H2,(H,30,35)(H,36,37)/t18-,19-,20-,23-/m1/s1
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n/an/a>1.50E+5n/an/an/an/a7.530



Sphinx Laboratories



Assay Description
PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.


J Med Chem 45: 2624-43 (2002)


Article DOI: 10.1021/jm020018f
BindingDB Entry DOI: 10.7270/Q2BG2M50
More data for this
Ligand-Target Pair
cAMP-dependent protein kinase catalytic subunit alpha


(Bos taurus (bovine))
BDBM3229
PNG
((3R,4R)-3-[(4-hydroxybenzene)amido]azepan-4-yl 3,5...)
Show SMILES Oc1ccc(cc1)C(=O)N[C@@H]1CNCCC[C@H]1OC(=O)c1cc(O)c(C(=O)c2ccc3ccccc3c2O)c(O)c1 |r|
Show InChI InChI=1S/C31H28N2O8/c34-20-10-7-18(8-11-20)30(39)33-23-16-32-13-3-6-26(23)41-31(40)19-14-24(35)27(25(36)15-19)29(38)22-12-9-17-4-1-2-5-21(17)28(22)37/h1-2,4-5,7-12,14-15,23,26,32,34-37H,3,6,13,16H2,(H,33,39)/t23-,26-/m1/s1
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n/an/a>1.50E+5n/an/an/an/an/an/a



Sphinx Laboratories



Assay Description
The activity of PKA, activated by cAMP, is measured by its ability to transfer phosphate from [gamma-32P]ATP to histone.


J Med Chem 45: 2624-43 (2002)


Article DOI: 10.1021/jm020018f
BindingDB Entry DOI: 10.7270/Q2BG2M50
More data for this
Ligand-Target Pair
Protein kinase C beta type


(Homo sapiens (Human))
BDBM3229
PNG
((3R,4R)-3-[(4-hydroxybenzene)amido]azepan-4-yl 3,5...)
Show SMILES Oc1ccc(cc1)C(=O)N[C@@H]1CNCCC[C@H]1OC(=O)c1cc(O)c(C(=O)c2ccc3ccccc3c2O)c(O)c1 |r|
Show InChI InChI=1S/C31H28N2O8/c34-20-10-7-18(8-11-20)30(39)33-23-16-32-13-3-6-26(23)41-31(40)19-14-24(35)27(25(36)15-19)29(38)22-12-9-17-4-1-2-5-21(17)28(22)37/h1-2,4-5,7-12,14-15,23,26,32,34-37H,3,6,13,16H2,(H,33,39)/t23-,26-/m1/s1
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n/an/a>1.50E+5n/an/an/an/an/an/a



Sphinx Laboratories



Assay Description
PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.


J Med Chem 45: 2624-43 (2002)


Article DOI: 10.1021/jm020018f
BindingDB Entry DOI: 10.7270/Q2BG2M50
More data for this
Ligand-Target Pair
Protein kinase C beta type


(Homo sapiens (Human))
BDBM3214
PNG
(4-trans-[(1-Carboxy-8-hydroxy-9-oxoxanthen-6-yl)ca...)
Show SMILES OC(=O)c1cccc2oc3cc(cc(O)c3c(=O)c12)C(=O)O[C@@H]1CCCNC[C@H]1NC(=O)c1ccc(O)cc1 |r|
Show InChI InChI=1S/C28H24N2O9/c31-16-8-6-14(7-9-16)26(34)30-18-13-29-10-2-5-20(18)39-28(37)15-11-19(32)24-22(12-15)38-21-4-1-3-17(27(35)36)23(21)25(24)33/h1,3-4,6-9,11-12,18,20,29,31-32H,2,5,10,13H2,(H,30,34)(H,35,36)/t18-,20-/m1/s1
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n/an/a>1.50E+5n/an/an/an/an/an/a



Sphinx Laboratories



Assay Description
PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.


J Med Chem 45: 2624-43 (2002)


Article DOI: 10.1021/jm020018f
BindingDB Entry DOI: 10.7270/Q2BG2M50
More data for this
Ligand-Target Pair
Protein kinase C alpha type


(Homo sapiens (Human))
BDBM3221
PNG
(2-{[2,6-dihydroxy-4-({[(3R,4R)-4-[(4-hydroxybenzen...)
Show SMILES OC(=O)c1ccccc1NC(=O)c1c(O)cc(cc1O)C(=O)O[C@@H]1CNC[C@H]1NC(=O)c1ccc(O)cc1 |r|
Show InChI InChI=1S/C26H23N3O9/c30-15-7-5-13(6-8-15)23(33)29-18-11-27-12-21(18)38-26(37)14-9-19(31)22(20(32)10-14)24(34)28-17-4-2-1-3-16(17)25(35)36/h1-10,18,21,27,30-32H,11-12H2,(H,28,34)(H,29,33)(H,35,36)/t18-,21-/m1/s1
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Sphinx Laboratories



Assay Description
PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.


J Med Chem 45: 2624-43 (2002)


Article DOI: 10.1021/jm020018f
BindingDB Entry DOI: 10.7270/Q2BG2M50
More data for this
Ligand-Target Pair
Protein kinase C beta type


(Homo sapiens (Human))
BDBM3222
PNG
(2-{[2,6-dihydroxy-4-({[(3R,4R)-4-[(4-hydroxybenzen...)
Show SMILES OC(=O)CN(C(=O)c1c(O)cc(cc1O)C(=O)O[C@@H]1CNC[C@H]1NC(=O)c1ccc(O)cc1)c1ccccc1 |r|
Show InChI InChI=1S/C27H25N3O9/c31-18-8-6-15(7-9-18)25(36)29-19-12-28-13-22(19)39-27(38)16-10-20(32)24(21(33)11-16)26(37)30(14-23(34)35)17-4-2-1-3-5-17/h1-11,19,22,28,31-33H,12-14H2,(H,29,36)(H,34,35)/t19-,22-/m1/s1
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Sphinx Laboratories



Assay Description
PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.


J Med Chem 45: 2624-43 (2002)


Article DOI: 10.1021/jm020018f
BindingDB Entry DOI: 10.7270/Q2BG2M50
More data for this
Ligand-Target Pair
Protein kinase C beta type


(Homo sapiens (Human))
BDBM3219
PNG
((3R,4R)-3-[(4-hydroxybenzene)amido]azepan-4-yl 4-[...)
Show SMILES COc1cc(cc(OC)c1C(=O)c1c(O)cccc1O)C(=O)O[C@@H]1CCCNC[C@H]1NC(=O)c1ccc(O)cc1 |r|
Show InChI InChI=1S/C29H30N2O9/c1-38-23-13-17(14-24(39-2)26(23)27(35)25-20(33)5-3-6-21(25)34)29(37)40-22-7-4-12-30-15-19(22)31-28(36)16-8-10-18(32)11-9-16/h3,5-6,8-11,13-14,19,22,30,32-34H,4,7,12,15H2,1-2H3,(H,31,36)/t19-,22-/m1/s1
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Sphinx Laboratories



Assay Description
PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.


J Med Chem 45: 2624-43 (2002)


Article DOI: 10.1021/jm020018f
BindingDB Entry DOI: 10.7270/Q2BG2M50
More data for this
Ligand-Target Pair
Protein kinase C beta type


(Homo sapiens (Human))
BDBM3209
PNG
((1R,2R)-2-{[2,6-dihydroxy-4-({[(3R,4R)-3-[(4-hydro...)
Show SMILES OC(=O)[C@@H]1CCCC[C@H]1C(=O)c1c(O)cc(cc1O)C(=O)O[C@@H]1CCCNC[C@H]1NC(=O)c1ccc(O)cc1 |r|
Show InChI InChI=1S/C28H32N2O9/c31-17-9-7-15(8-10-17)26(35)30-20-14-29-11-3-6-23(20)39-28(38)16-12-21(32)24(22(33)13-16)25(34)18-4-1-2-5-19(18)27(36)37/h7-10,12-13,18-20,23,29,31-33H,1-6,11,14H2,(H,30,35)(H,36,37)/t18-,19-,20-,23-/m1/s1
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n/an/a>1.50E+5n/an/an/an/a7.530



Sphinx Laboratories



Assay Description
PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.


J Med Chem 45: 2624-43 (2002)


Article DOI: 10.1021/jm020018f
BindingDB Entry DOI: 10.7270/Q2BG2M50
More data for this
Ligand-Target Pair
Protein kinase C alpha type


(Homo sapiens (Human))
BDBM3219
PNG
((3R,4R)-3-[(4-hydroxybenzene)amido]azepan-4-yl 4-[...)
Show SMILES COc1cc(cc(OC)c1C(=O)c1c(O)cccc1O)C(=O)O[C@@H]1CCCNC[C@H]1NC(=O)c1ccc(O)cc1 |r|
Show InChI InChI=1S/C29H30N2O9/c1-38-23-13-17(14-24(39-2)26(23)27(35)25-20(33)5-3-6-21(25)34)29(37)40-22-7-4-12-30-15-19(22)31-28(36)16-8-10-18(32)11-9-16/h3,5-6,8-11,13-14,19,22,30,32-34H,4,7,12,15H2,1-2H3,(H,31,36)/t19-,22-/m1/s1
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Sphinx Laboratories



Assay Description
PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.


J Med Chem 45: 2624-43 (2002)


Article DOI: 10.1021/jm020018f
BindingDB Entry DOI: 10.7270/Q2BG2M50
More data for this
Ligand-Target Pair
Protein kinase C alpha type


(Homo sapiens (Human))
BDBM3222
PNG
(2-{[2,6-dihydroxy-4-({[(3R,4R)-4-[(4-hydroxybenzen...)
Show SMILES OC(=O)CN(C(=O)c1c(O)cc(cc1O)C(=O)O[C@@H]1CNC[C@H]1NC(=O)c1ccc(O)cc1)c1ccccc1 |r|
Show InChI InChI=1S/C27H25N3O9/c31-18-8-6-15(7-9-18)25(36)29-19-12-28-13-22(19)39-27(38)16-10-20(32)24(21(33)11-16)26(37)30(14-23(34)35)17-4-2-1-3-5-17/h1-11,19,22,28,31-33H,12-14H2,(H,29,36)(H,34,35)/t19-,22-/m1/s1
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Sphinx Laboratories



Assay Description
PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.


J Med Chem 45: 2624-43 (2002)


Article DOI: 10.1021/jm020018f
BindingDB Entry DOI: 10.7270/Q2BG2M50
More data for this
Ligand-Target Pair
Protein kinase C epsilon type


(Homo sapiens (Human))
BDBM3222
PNG
(2-{[2,6-dihydroxy-4-({[(3R,4R)-4-[(4-hydroxybenzen...)
Show SMILES OC(=O)CN(C(=O)c1c(O)cc(cc1O)C(=O)O[C@@H]1CNC[C@H]1NC(=O)c1ccc(O)cc1)c1ccccc1 |r|
Show InChI InChI=1S/C27H25N3O9/c31-18-8-6-15(7-9-18)25(36)29-19-12-28-13-22(19)39-27(38)16-10-20(32)24(21(33)11-16)26(37)30(14-23(34)35)17-4-2-1-3-5-17/h1-11,19,22,28,31-33H,12-14H2,(H,29,36)(H,34,35)/t19-,22-/m1/s1
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Sphinx Laboratories



Assay Description
PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.


J Med Chem 45: 2624-43 (2002)


Article DOI: 10.1021/jm020018f
BindingDB Entry DOI: 10.7270/Q2BG2M50
More data for this
Ligand-Target Pair
Protein kinase C alpha type


(Homo sapiens (Human))
BDBM3229
PNG
((3R,4R)-3-[(4-hydroxybenzene)amido]azepan-4-yl 3,5...)
Show SMILES Oc1ccc(cc1)C(=O)N[C@@H]1CNCCC[C@H]1OC(=O)c1cc(O)c(C(=O)c2ccc3ccccc3c2O)c(O)c1 |r|
Show InChI InChI=1S/C31H28N2O8/c34-20-10-7-18(8-11-20)30(39)33-23-16-32-13-3-6-26(23)41-31(40)19-14-24(35)27(25(36)15-19)29(38)22-12-9-17-4-1-2-5-21(17)28(22)37/h1-2,4-5,7-12,14-15,23,26,32,34-37H,3,6,13,16H2,(H,33,39)/t23-,26-/m1/s1
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PubMed
n/an/a>1.50E+5n/an/an/an/an/an/a



Sphinx Laboratories



Assay Description
PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.


J Med Chem 45: 2624-43 (2002)


Article DOI: 10.1021/jm020018f
BindingDB Entry DOI: 10.7270/Q2BG2M50
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%