Affinity Data by PubMed id=14741251

PubMed code 14741251

Found 12 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Beta-secretase 1 (Homo sapiens (Human))	BDBM50139111 ((4R,6S,7S)-7-[(S)-3-Carboxy-3-(3-methyl-butyrylami...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	PubMed	1.70E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Tested for inhibition of Beta-secretase 1 (BACE 1) expressed in insect cell using baculovirus				Bioorg Med Chem Lett 14: 601-4 (2004) BindingDB Entry DOI: 10.7270/Q21835X0
Merck Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Beta-secretase 1 (Homo sapiens (Human))	BDBM50139112 ((S)-N-((1S,2S,4R)-1-Benzyl-2,6-dihydroxy-4-isobuty...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	PubMed	1.90E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Tested for inhibition of Beta-secretase 1 (BACE 1) expressed in insect cell using baculovirus				Bioorg Med Chem Lett 14: 601-4 (2004) BindingDB Entry DOI: 10.7270/Q21835X0
Merck Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Renin (Homo sapiens (Human))	BDBM50139109 ((S)-N-((1S,2S,4R)-6-Acetoxy-1-benzyl-2-hydroxy-4-i...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	PubMed	1.90E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Compound was tested for inhibition of human renin				Bioorg Med Chem Lett 14: 601-4 (2004) BindingDB Entry DOI: 10.7270/Q21835X0
Merck Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Cathepsin D (Homo sapiens (Human))	BDBM50139109 ((S)-N-((1S,2S,4R)-6-Acetoxy-1-benzyl-2-hydroxy-4-i...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	PubMed	2.20E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Compound was tested for inhibition of cathepsin D				Bioorg Med Chem Lett 14: 601-4 (2004) BindingDB Entry DOI: 10.7270/Q21835X0
Merck Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Beta-secretase 1 (Homo sapiens (Human))	BDBM50139109 ((S)-N-((1S,2S,4R)-6-Acetoxy-1-benzyl-2-hydroxy-4-i...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	PubMed	2.70E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Tested for inhibition of Beta-secretase 1 (BACE 1) expressed in insect cell using baculovirus				Bioorg Med Chem Lett 14: 601-4 (2004) BindingDB Entry DOI: 10.7270/Q21835X0
Merck Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Renin (Homo sapiens (Human))	BDBM50139112 ((S)-N-((1S,2S,4R)-1-Benzyl-2,6-dihydroxy-4-isobuty...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	PubMed	1.09E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Compound was tested for inhibition of human renin				Bioorg Med Chem Lett 14: 601-4 (2004) BindingDB Entry DOI: 10.7270/Q21835X0
Merck Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Cathepsin D (Homo sapiens (Human))	BDBM50139112 ((S)-N-((1S,2S,4R)-1-Benzyl-2,6-dihydroxy-4-isobuty...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	PubMed	1.25E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Compound was tested for inhibition of cathepsin D				Bioorg Med Chem Lett 14: 601-4 (2004) BindingDB Entry DOI: 10.7270/Q21835X0
Merck Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Renin (Homo sapiens (Human))	BDBM50139110 ((S)-N-((1S,2S,4R)-1-Benzyl-2-hydroxy-4-isobutylcar...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	PubMed	2.44E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Compound was tested for inhibition of human renin				Bioorg Med Chem Lett 14: 601-4 (2004) BindingDB Entry DOI: 10.7270/Q21835X0
Merck Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Cathepsin D (Homo sapiens (Human))	BDBM50139110 ((S)-N-((1S,2S,4R)-1-Benzyl-2-hydroxy-4-isobutylcar...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	PubMed	2.80E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Compound was tested for inhibition of cathepsin D				Bioorg Med Chem Lett 14: 601-4 (2004) BindingDB Entry DOI: 10.7270/Q21835X0
Merck Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Beta-secretase 1 (Homo sapiens (Human))	BDBM50139110 ((S)-N-((1S,2S,4R)-1-Benzyl-2-hydroxy-4-isobutylcar...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	PubMed	6.95E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Tested for inhibition of Beta-secretase 1 (BACE 1) expressed in insect cell using baculovirus				Bioorg Med Chem Lett 14: 601-4 (2004) BindingDB Entry DOI: 10.7270/Q21835X0
Merck Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Renin (Homo sapiens (Human))	BDBM50139111 ((4R,6S,7S)-7-[(S)-3-Carboxy-3-(3-methyl-butyrylami...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	PubMed	7.36E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Compound was tested for inhibition of human renin				Bioorg Med Chem Lett 14: 601-4 (2004) BindingDB Entry DOI: 10.7270/Q21835X0
Merck Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Cathepsin D (Homo sapiens (Human))	BDBM50139111 ((4R,6S,7S)-7-[(S)-3-Carboxy-3-(3-methyl-butyrylami...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	PubMed	7.97E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Compound was tested for inhibition of cathepsin D				Bioorg Med Chem Lett 14: 601-4 (2004) BindingDB Entry DOI: 10.7270/Q21835X0
Merck Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair

* indicates data uncertainty>20%