Affinity Data by PubMed id=15163206

PubMed code 15163206

Found 18 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Histamine H3 receptor (Rattus norvegicus (rat))	BDBM22914 (CHEMBL260374 \| N-cyclohexyl-4-(1H-imidazol-5-yl)pi...) Show SMILES S=C(NC1CCCCC1)N1CCC(CC1)c1cnc[nH]1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University College London Curated by ChEMBL					Assay Description In vitro inhibitory activity against against histamine H3 receptor using [3H]-Histamine as radioligand from rat cerebral cortex synaptosomes				J Med Chem 47: 3264-74 (2004) Article DOI: 10.1021/jm031141p BindingDB Entry DOI: 10.7270/Q2F47NK5
University College London Curated by ChEMBL					More data for this Ligand-Target Pair
Histamine H3 receptor (Rattus norvegicus (rat))	BDBM50148122 (4-[3-(3-Trifluoromethyl-phenoxy)-propyl]-1H-imidaz...) Show SMILES FC(F)(F)c1cccc(OCCCc2cnc[nH]2)c1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	8.40	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University College London Curated by ChEMBL					Assay Description In vitro inhibitory activity against against histamine H3 receptor using [3H]-Histamine as radioligand from rat cerebral cortex synaptosomes				J Med Chem 47: 3264-74 (2004) Article DOI: 10.1021/jm031141p BindingDB Entry DOI: 10.7270/Q2F47NK5
University College London Curated by ChEMBL					More data for this Ligand-Target Pair
Histamine H3 receptor (Rattus norvegicus (rat))	BDBM50148120 (4-[3-(3-Nitro-phenoxy)-propyl]-1H-imidazole \| CHEM...) Show SMILES [O-][N+](=O)c1cccc(OCCCc2cnc[nH]2)c1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	9.40	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University College London Curated by ChEMBL					Assay Description In vitro inhibitory activity against against histamine H3 receptor using [3H]-Histamine as radioligand from rat cerebral cortex synaptosomes				J Med Chem 47: 3264-74 (2004) Article DOI: 10.1021/jm031141p BindingDB Entry DOI: 10.7270/Q2F47NK5
University College London Curated by ChEMBL					More data for this Ligand-Target Pair
Histamine H3 receptor (Rattus norvegicus (rat))	BDBM50053278 (4-[3-(1H-Imidazol-4-yl)-propoxy]-benzonitrile \| 4-...) Show SMILES N#Cc1ccc(OCCCc2cnc[nH]2)cc1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	12	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University College London Curated by ChEMBL					Assay Description In vitro inhibitory activity against against histamine H3 receptor using [3H]-Histamine as radioligand from rat cerebral cortex synaptosomes				J Med Chem 47: 3264-74 (2004) Article DOI: 10.1021/jm031141p BindingDB Entry DOI: 10.7270/Q2F47NK5
University College London Curated by ChEMBL					More data for this Ligand-Target Pair
Histamine H3 receptor (Rattus norvegicus (rat))	BDBM50053298 (4-[3-(4-Trifluoromethyl-phenoxy)-propyl]-1H-imidaz...) Show SMILES FC(F)(F)c1ccc(OCCCc2cnc[nH]2)cc1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	14	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University College London Curated by ChEMBL					Assay Description In vitro inhibitory activity against against histamine H3 receptor using [3H]-Histamine as radioligand from rat cerebral cortex synaptosomes				J Med Chem 47: 3264-74 (2004) Article DOI: 10.1021/jm031141p BindingDB Entry DOI: 10.7270/Q2F47NK5
University College London Curated by ChEMBL					More data for this Ligand-Target Pair
Histamine H3 receptor (Rattus norvegicus (rat))	BDBM50148121 (4-[3-(3-Ethyl-phenoxy)-propyl]-1H-imidazole \| CHEM...) Show SMILES CCc1cccc(OCCCc2cnc[nH]2)c1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	15	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University College London Curated by ChEMBL					Assay Description In vitro inhibitory activity against against histamine H3 receptor using [3H]-Histamine as radioligand from rat cerebral cortex synaptosomes				J Med Chem 47: 3264-74 (2004) Article DOI: 10.1021/jm031141p BindingDB Entry DOI: 10.7270/Q2F47NK5
University College London Curated by ChEMBL					More data for this Ligand-Target Pair
Histamine H3 receptor (Rattus norvegicus (rat))	BDBM50148116 (4-[2-(3-Trifluoromethyl-phenoxy)-ethyl]-1H-imidazo...) Show SMILES FC(F)(F)c1cccc(OCCc2cnc[nH]2)c1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	18	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University College London Curated by ChEMBL					Assay Description In vitro inhibitory activity against against histamine H3 receptor using [3H]-Histamine as radioligand from rat cerebral cortex synaptosomes				J Med Chem 47: 3264-74 (2004) Article DOI: 10.1021/jm031141p BindingDB Entry DOI: 10.7270/Q2F47NK5
University College London Curated by ChEMBL					More data for this Ligand-Target Pair
Histamine H3 receptor (Rattus norvegicus (rat))	BDBM50148117 (4-[3-(3-Bromo-phenoxy)-propyl]-1H-imidazole \| CHEM...) Show SMILES Brc1cccc(OCCCc2cnc[nH]2)c1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	19	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University College London Curated by ChEMBL					Assay Description In vitro inhibitory activity against against histamine H3 receptor using [3H]-Histamine as radioligand from rat cerebral cortex synaptosomes				J Med Chem 47: 3264-74 (2004) Article DOI: 10.1021/jm031141p BindingDB Entry DOI: 10.7270/Q2F47NK5
University College London Curated by ChEMBL					More data for this Ligand-Target Pair
Histamine H3 receptor (Rattus norvegicus (rat))	BDBM50409931 (CHEMBL2112499) Show SMILES CC(=O)c1cccc(OCCCc2cnc[nH]2)c1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	20	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University College London Curated by ChEMBL					Assay Description In vitro inhibitory activity against against histamine H3 receptor using [3H]-Histamine as radioligand from rat cerebral cortex synaptosomes				J Med Chem 47: 3264-74 (2004) Article DOI: 10.1021/jm031141p BindingDB Entry DOI: 10.7270/Q2F47NK5
University College London Curated by ChEMBL					More data for this Ligand-Target Pair
Histamine H3 receptor (Rattus norvegicus (rat))	BDBM50148125 (4-[3-(3-tert-Butyl-phenoxy)-propyl]-1H-imidazole \|...) Show SMILES CC(C)(C)c1cccc(OCCCc2cnc[nH]2)c1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	22	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University College London Curated by ChEMBL					Assay Description In vitro inhibitory activity against against histamine H3 receptor using [3H]-Histamine as radioligand from rat cerebral cortex synaptosomes				J Med Chem 47: 3264-74 (2004) Article DOI: 10.1021/jm031141p BindingDB Entry DOI: 10.7270/Q2F47NK5
University College London Curated by ChEMBL					More data for this Ligand-Target Pair
Histamine H3 receptor (Rattus norvegicus (rat))	BDBM50148114 (4-[2-(3-Trifluoromethyl-phenylsulfanyl)-ethyl]-1H-...) Show SMILES FC(F)(F)c1cccc(SCCc2cnc[nH]2)c1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	23	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University College London Curated by ChEMBL					Assay Description In vitro inhibitory activity against against histamine H3 receptor using [3H]-Histamine as radioligand from rat cerebral cortex synaptosomes				J Med Chem 47: 3264-74 (2004) Article DOI: 10.1021/jm031141p BindingDB Entry DOI: 10.7270/Q2F47NK5
University College London Curated by ChEMBL					More data for this Ligand-Target Pair
Histamine H3 receptor (Rattus norvegicus (rat))	BDBM50148124 (4-[3-(3-Isopropyl-phenoxy)-propyl]-1H-imidazole \| ...) Show SMILES CC(C)c1cccc(OCCCc2cnc[nH]2)c1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	29	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University College London Curated by ChEMBL					Assay Description In vitro inhibitory activity against against histamine H3 receptor using [3H]-Histamine as radioligand from rat cerebral cortex synaptosomes				J Med Chem 47: 3264-74 (2004) Article DOI: 10.1021/jm031141p BindingDB Entry DOI: 10.7270/Q2F47NK5
University College London Curated by ChEMBL					More data for this Ligand-Target Pair
Histamine H3 receptor (Rattus norvegicus (rat))	BDBM50148115 (4-(3-m-Tolyloxy-propyl)-1H-imidazole \| CHEMBL11041...) Show SMILES Cc1cccc(OCCCc2cnc[nH]2)c1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	37	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University College London Curated by ChEMBL					Assay Description In vitro inhibitory activity against against histamine H3 receptor using [3H]-Histamine as radioligand from rat cerebral cortex synaptosomes				J Med Chem 47: 3264-74 (2004) Article DOI: 10.1021/jm031141p BindingDB Entry DOI: 10.7270/Q2F47NK5
University College London Curated by ChEMBL					More data for this Ligand-Target Pair
Histamine H3 receptor (Rattus norvegicus (rat))	BDBM50148113 (4-[3-(3-Trifluoromethyl-phenylsulfanyl)-propyl]-1H...) Show SMILES FC(F)(F)c1cccc(SCCCc2cnc[nH]2)c1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	38	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University College London Curated by ChEMBL					Assay Description In vitro inhibitory activity against against histamine H3 receptor using [3H]-Histamine as radioligand from rat cerebral cortex synaptosomes				J Med Chem 47: 3264-74 (2004) Article DOI: 10.1021/jm031141p BindingDB Entry DOI: 10.7270/Q2F47NK5
University College London Curated by ChEMBL					More data for this Ligand-Target Pair
Histamine H3 receptor (Rattus norvegicus (rat))	BDBM50148118 (4-[4-(3-Trifluoromethyl-phenyl)-butyl]-1H-imidazol...) Show SMILES FC(F)(F)c1cccc(CCCCc2cnc[nH]2)c1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	38	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University College London Curated by ChEMBL					Assay Description In vitro inhibitory activity against against histamine H3 receptor using [3H]-Histamine as radioligand from rat cerebral cortex synaptosomes				J Med Chem 47: 3264-74 (2004) Article DOI: 10.1021/jm031141p BindingDB Entry DOI: 10.7270/Q2F47NK5
University College London Curated by ChEMBL					More data for this Ligand-Target Pair
Histamine H3 receptor (Rattus norvegicus (rat))	BDBM50092833 (4-(3-Phenoxy-propyl)-1H-imidazole with (0.95M)oxal...) Show SMILES C(COc1ccccc1)Cc1cnc[nH]1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	55	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University College London Curated by ChEMBL					Assay Description In vitro inhibitory activity against against histamine H3 receptor using [3H]-Histamine as radioligand from rat cerebral cortex synaptosomes				J Med Chem 47: 3264-74 (2004) Article DOI: 10.1021/jm031141p BindingDB Entry DOI: 10.7270/Q2F47NK5
University College London Curated by ChEMBL					More data for this Ligand-Target Pair
Histamine H3 receptor (Rattus norvegicus (rat))	BDBM50148119 (3-[3-(1H-Imidazol-4-yl)-propoxy]-benzonitrile \| CH...) Show SMILES N#Cc1cccc(OCCCc2cnc[nH]2)c1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	108	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University College London Curated by ChEMBL					Assay Description In vitro inhibitory activity against against histamine H3 receptor using [3H]-Histamine as radioligand from rat cerebral cortex synaptosomes				J Med Chem 47: 3264-74 (2004) Article DOI: 10.1021/jm031141p BindingDB Entry DOI: 10.7270/Q2F47NK5
University College London Curated by ChEMBL					More data for this Ligand-Target Pair
Histamine H3 receptor (Rattus norvegicus (rat))	BDBM50148123 (4-[3-(3,5-Bis-trifluoromethyl-phenoxy)-propyl]-1H-...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	116	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University College London Curated by ChEMBL					Assay Description In vitro inhibitory activity against against histamine H3 receptor using [3H]-Histamine as radioligand from rat cerebral cortex synaptosomes				J Med Chem 47: 3264-74 (2004) Article DOI: 10.1021/jm031141p BindingDB Entry DOI: 10.7270/Q2F47NK5
University College London Curated by ChEMBL					More data for this Ligand-Target Pair

* indicates data uncertainty>20%