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PubMed code 15261292

Compile data set for download or QSAR
Found 28 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
C-X-C chemokine receptor type 1


(Homo sapiens (Human))		BDBM50150572
PNG
(1-(2-Bromo-phenyl)-3-(2,4-dihydroxy-phenyl)-urea |...)
Show SMILES Oc1ccc(NC(=O)Nc2ccccc2Br)c(O)c1
Show InChI InChI=1S/C13H11BrN2O3/c14-9-3-1-2-4-10(9)15-13(19)16-11-6-5-8(17)7-12(11)18/h1-7,17-18H,(H2,15,16,19)
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n/an/a 22n/an/an/an/an/an/a



Johnson and Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibitory concentration against interleukin-8 receptor of human neutrophils by using [125I]-IL-8 (0.125 nM) as radioligand

Bioorg Med Chem Lett 14: 4307-11 (2004)


Article DOI: 10.1016/j.bmcl.2004.05.080
BindingDB Entry DOI: 10.7270/Q23F4P4M
More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 1


(Homo sapiens (Human))		BDBM50150573
PNG
(1-{4-[5-(4-Chloro-phenyl)-isoxazol-3-yl]-phenoxyme...)
Show SMILES CN1CCN(COc2ccc(cc2)-c2cc(on2)-c2ccc(Cl)cc2)CC1
Show InChI InChI=1S/C21H22ClN3O2/c1-24-10-12-25(13-11-24)15-26-19-8-4-16(5-9-19)20-14-21(27-23-20)17-2-6-18(22)7-3-17/h2-9,14H,10-13,15H2,1H3
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n/an/a 1.60E+3n/an/an/an/an/an/a



Johnson and Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibitory concentration against interleukin-8 receptor of human neutrophils by using [125I]-IL-8 (0.125 nM) as radioligand

Bioorg Med Chem Lett 14: 4307-11 (2004)


Article DOI: 10.1016/j.bmcl.2004.05.080
BindingDB Entry DOI: 10.7270/Q23F4P4M
More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 1


(Homo sapiens (Human))		BDBM50150561
PNG
(1-(3-{4-[3-(4-Fluoro-phenyl)-isoxazol-5-yl]-phenox...)
Show SMILES CN1CCN(CCCOc2ccc(cc2)-c2cc(no2)-c2ccc(F)cc2)CC1
Show InChI InChI=1S/C23H26FN3O2/c1-26-12-14-27(15-13-26)11-2-16-28-21-9-5-19(6-10-21)23-17-22(25-29-23)18-3-7-20(24)8-4-18/h3-10,17H,2,11-16H2,1H3
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n/an/a 2.00E+3n/an/an/an/an/an/a



Johnson and Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibitory concentration against interleukin-8 receptor of human neutrophils by using [125I]-IL-8 (0.125 nM) as radioligand

Bioorg Med Chem Lett 14: 4307-11 (2004)


Article DOI: 10.1016/j.bmcl.2004.05.080
BindingDB Entry DOI: 10.7270/Q23F4P4M
More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 1


(Homo sapiens (Human))		BDBM50150558
PNG
(1-(3-{4-[3-(4-Chloro-phenyl)-isoxazol-5-yl]-phenox...)
Show SMILES CN1CCN(CCCOc2ccc(cc2)-c2cc(no2)-c2ccc(Cl)cc2)CC1
Show InChI InChI=1S/C23H26ClN3O2/c1-26-12-14-27(15-13-26)11-2-16-28-21-9-5-19(6-10-21)23-17-22(25-29-23)18-3-7-20(24)8-4-18/h3-10,17H,2,11-16H2,1H3
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n/an/a 2.10E+3n/an/an/an/an/an/a



Johnson and Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibitory concentration against interleukin-8 receptor of human neutrophils by using [125I]-IL-8 (0.125 nM) as radioligand

Bioorg Med Chem Lett 14: 4307-11 (2004)


Article DOI: 10.1016/j.bmcl.2004.05.080
BindingDB Entry DOI: 10.7270/Q23F4P4M
More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 1


(Homo sapiens (Human))		BDBM50150555
PNG
(1-(3-{4-[3-(4-Chloro-phenyl)-[1,2,4]oxadiazol-5-yl...)
Show SMILES CN1CCN(CCCOc2ccc(cc2)-c2nc(no2)-c2ccc(Cl)cc2)CC1
Show InChI InChI=1S/C22H25ClN4O2/c1-26-12-14-27(15-13-26)11-2-16-28-20-9-5-18(6-10-20)22-24-21(25-29-22)17-3-7-19(23)8-4-17/h3-10H,2,11-16H2,1H3
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n/an/a 2.50E+3n/an/an/an/an/an/a



Johnson and Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibitory concentration against interleukin-8 receptor of human neutrophils by using [125I]-IL-8 (0.125 nM) as radioligand

Bioorg Med Chem Lett 14: 4307-11 (2004)


Article DOI: 10.1016/j.bmcl.2004.05.080
BindingDB Entry DOI: 10.7270/Q23F4P4M
More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 1


(Homo sapiens (Human))		BDBM50150563
PNG
(CHEMBL183061 | {4-[5-(4-Chloro-phenyl)-isoxazol-3-...)
Show SMILES CN(C)COc1ccc(cc1)-c1cc(on1)-c1ccc(Cl)cc1
Show InChI InChI=1S/C18H17ClN2O2/c1-21(2)12-22-16-9-5-13(6-10-16)17-11-18(23-20-17)14-3-7-15(19)8-4-14/h3-11H,12H2,1-2H3
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n/an/a 2.70E+3n/an/an/an/an/an/a



Johnson and Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibitory concentration against interleukin-8 receptor of human neutrophils by using [125I]-IL-8 (0.125 nM) as radioligand

Bioorg Med Chem Lett 14: 4307-11 (2004)


Article DOI: 10.1016/j.bmcl.2004.05.080
BindingDB Entry DOI: 10.7270/Q23F4P4M
More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 1


(Homo sapiens (Human))		BDBM50150553
PNG
(1-Methyl-4-{3-[4-(3-phenyl-isoxazol-5-yl)-phenoxy]...)
Show SMILES CN1CCN(CCCOc2ccc(cc2)-c2cc(no2)-c2ccccc2)CC1
Show InChI InChI=1S/C23H27N3O2/c1-25-13-15-26(16-14-25)12-5-17-27-21-10-8-20(9-11-21)23-18-22(24-28-23)19-6-3-2-4-7-19/h2-4,6-11,18H,5,12-17H2,1H3
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n/an/a 3.00E+3n/an/an/an/an/an/a



Johnson and Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibitory concentration against interleukin-8 receptor of human neutrophils by using [125I]-IL-8 (0.125 nM) as radioligand

Bioorg Med Chem Lett 14: 4307-11 (2004)


Article DOI: 10.1016/j.bmcl.2004.05.080
BindingDB Entry DOI: 10.7270/Q23F4P4M
More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 1


(Homo sapiens (Human))		BDBM50150559
PNG
(CHEMBL182361 | {4-[5-(4-Fluoro-phenyl)-isoxazol-3-...)
Show SMILES CN(C)COc1ccc(cc1)-c1cc(on1)-c1ccc(F)cc1
Show InChI InChI=1S/C18H17FN2O2/c1-21(2)12-22-16-9-5-13(6-10-16)17-11-18(23-20-17)14-3-7-15(19)8-4-14/h3-11H,12H2,1-2H3
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n/an/a 3.10E+3n/an/an/an/an/an/a



Johnson and Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibitory concentration against interleukin-8 receptor of human neutrophils by using [125I]-IL-8 (0.125 nM) as radioligand

Bioorg Med Chem Lett 14: 4307-11 (2004)


Article DOI: 10.1016/j.bmcl.2004.05.080
BindingDB Entry DOI: 10.7270/Q23F4P4M
More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 1


(Homo sapiens (Human))		BDBM50150558
PNG
(1-(3-{4-[3-(4-Chloro-phenyl)-isoxazol-5-yl]-phenox...)
Show SMILES CN1CCN(CCCOc2ccc(cc2)-c2cc(no2)-c2ccc(Cl)cc2)CC1
Show InChI InChI=1S/C23H26ClN3O2/c1-26-12-14-27(15-13-26)11-2-16-28-21-9-5-19(6-10-21)23-17-22(25-29-23)18-3-7-20(24)8-4-18/h3-10,17H,2,11-16H2,1H3
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n/an/a 3.60E+3n/an/an/an/an/an/a



Johnson and Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibition of interleukin-8 induced elastase release from human neutrophils

Bioorg Med Chem Lett 14: 4307-11 (2004)


Article DOI: 10.1016/j.bmcl.2004.05.080
BindingDB Entry DOI: 10.7270/Q23F4P4M
More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 1


(Homo sapiens (Human))		BDBM50150561
PNG
(1-(3-{4-[3-(4-Fluoro-phenyl)-isoxazol-5-yl]-phenox...)
Show SMILES CN1CCN(CCCOc2ccc(cc2)-c2cc(no2)-c2ccc(F)cc2)CC1
Show InChI InChI=1S/C23H26FN3O2/c1-26-12-14-27(15-13-26)11-2-16-28-21-9-5-19(6-10-21)23-17-22(25-29-23)18-3-7-20(24)8-4-18/h3-10,17H,2,11-16H2,1H3
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n/an/a 3.80E+3n/an/an/an/an/an/a



Johnson and Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibition of interleukin-8 induced elastase release from human neutrophils

Bioorg Med Chem Lett 14: 4307-11 (2004)


Article DOI: 10.1016/j.bmcl.2004.05.080
BindingDB Entry DOI: 10.7270/Q23F4P4M
More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 1


(Homo sapiens (Human))		BDBM50150569
PNG
((3-{4-[3-(4-Chloro-phenyl)-isoxazol-5-yl]-phenoxy}...)
Show SMILES CN(C)CCCOc1ccc(cc1)-c1cc(no1)-c1ccc(Cl)cc1
Show InChI InChI=1S/C20H21ClN2O2/c1-23(2)12-3-13-24-18-10-6-16(7-11-18)20-14-19(22-25-20)15-4-8-17(21)9-5-15/h4-11,14H,3,12-13H2,1-2H3
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n/an/a 3.90E+3n/an/an/an/an/an/a



Johnson and Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibitory concentration against interleukin-8 receptor of human neutrophils by using [125I]-IL-8 (0.125 nM) as radioligand

Bioorg Med Chem Lett 14: 4307-11 (2004)


Article DOI: 10.1016/j.bmcl.2004.05.080
BindingDB Entry DOI: 10.7270/Q23F4P4M
More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 1


(Homo sapiens (Human))		BDBM50150559
PNG
(CHEMBL182361 | {4-[5-(4-Fluoro-phenyl)-isoxazol-3-...)
Show SMILES CN(C)COc1ccc(cc1)-c1cc(on1)-c1ccc(F)cc1
Show InChI InChI=1S/C18H17FN2O2/c1-21(2)12-22-16-9-5-13(6-10-16)17-11-18(23-20-17)14-3-7-15(19)8-4-14/h3-11H,12H2,1-2H3
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n/an/a 4.00E+3n/an/an/an/an/an/a



Johnson and Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibition of interleukin-8 induced elastase release from human neutrophils

Bioorg Med Chem Lett 14: 4307-11 (2004)


Article DOI: 10.1016/j.bmcl.2004.05.080
BindingDB Entry DOI: 10.7270/Q23F4P4M
More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 1


(Homo sapiens (Human))		BDBM50150574
PNG
(CHEMBL413959 | {2-[5-(4-Chloro-phenyl)-isoxazol-3-...)
Show SMILES CN(C)COc1ccccc1-c1cc(on1)-c1ccc(Cl)cc1
Show InChI InChI=1S/C18H17ClN2O2/c1-21(2)12-22-17-6-4-3-5-15(17)16-11-18(23-20-16)13-7-9-14(19)10-8-13/h3-11H,12H2,1-2H3
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n/an/a 4.40E+3n/an/an/an/an/an/a



Johnson and Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibitory concentration against interleukin-8 receptor of human neutrophils by using [125I]-IL-8 (0.125 nM) as radioligand

Bioorg Med Chem Lett 14: 4307-11 (2004)


Article DOI: 10.1016/j.bmcl.2004.05.080
BindingDB Entry DOI: 10.7270/Q23F4P4M
More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 1


(Homo sapiens (Human))		BDBM50150555
PNG
(1-(3-{4-[3-(4-Chloro-phenyl)-[1,2,4]oxadiazol-5-yl...)
Show SMILES CN1CCN(CCCOc2ccc(cc2)-c2nc(no2)-c2ccc(Cl)cc2)CC1
Show InChI InChI=1S/C22H25ClN4O2/c1-26-12-14-27(15-13-26)11-2-16-28-20-9-5-18(6-10-20)22-24-21(25-29-22)17-3-7-19(23)8-4-17/h3-10H,2,11-16H2,1H3
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n/an/a 4.50E+3n/an/an/an/an/an/a



Johnson and Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibition of interleukin-8 induced elastase release from human neutrophils

Bioorg Med Chem Lett 14: 4307-11 (2004)


Article DOI: 10.1016/j.bmcl.2004.05.080
BindingDB Entry DOI: 10.7270/Q23F4P4M
More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 1


(Homo sapiens (Human))		BDBM50150567
PNG
(1-[4-(5-Phenyl-isoxazol-3-yl)-phenoxymethyl]-piper...)
Show SMILES C(Oc1ccc(cc1)-c1cc(on1)-c1ccccc1)N1CCCCC1
Show InChI InChI=1S/C21H22N2O2/c1-3-7-18(8-4-1)21-15-20(22-25-21)17-9-11-19(12-10-17)24-16-23-13-5-2-6-14-23/h1,3-4,7-12,15H,2,5-6,13-14,16H2
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n/an/a 5.40E+3n/an/an/an/an/an/a



Johnson and Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibitory concentration against interleukin-8 receptor of human neutrophils by using [125I]-IL-8 (0.125 nM) as radioligand

Bioorg Med Chem Lett 14: 4307-11 (2004)


Article DOI: 10.1016/j.bmcl.2004.05.080
BindingDB Entry DOI: 10.7270/Q23F4P4M
More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 1


(Homo sapiens (Human))		BDBM50150556
PNG
(1-Methyl-4-(3-{4-[3-(3-trifluoromethyl-phenyl)-iso...)
Show SMILES CN1CCN(CCCOc2ccc(cc2)-c2cc(no2)-c2cccc(c2)C(F)(F)F)CC1
Show InChI InChI=1S/C24H26F3N3O2/c1-29-11-13-30(14-12-29)10-3-15-31-21-8-6-18(7-9-21)23-17-22(28-32-23)19-4-2-5-20(16-19)24(25,26)27/h2,4-9,16-17H,3,10-15H2,1H3
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n/an/a 6.00E+3n/an/an/an/an/an/a



Johnson and Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibitory concentration against interleukin-8 receptor of human neutrophils by using [125I]-IL-8 (0.125 nM) as radioligand

Bioorg Med Chem Lett 14: 4307-11 (2004)


Article DOI: 10.1016/j.bmcl.2004.05.080
BindingDB Entry DOI: 10.7270/Q23F4P4M
More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 1


(Homo sapiens (Human))		BDBM50150566
PNG
(1-Methyl-4-[4-(5-phenyl-isoxazol-3-yl)-phenoxymeth...)
Show SMILES CN1CCN(COc2ccc(cc2)-c2cc(on2)-c2ccccc2)CC1
Show InChI InChI=1S/C21H23N3O2/c1-23-11-13-24(14-12-23)16-25-19-9-7-17(8-10-19)20-15-21(26-22-20)18-5-3-2-4-6-18/h2-10,15H,11-14,16H2,1H3
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n/an/a 6.20E+3n/an/an/an/an/an/a



Johnson and Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibitory concentration against interleukin-8 receptor of human neutrophils by using [125I]-IL-8 (0.125 nM) as radioligand

Bioorg Med Chem Lett 14: 4307-11 (2004)


Article DOI: 10.1016/j.bmcl.2004.05.080
BindingDB Entry DOI: 10.7270/Q23F4P4M
More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 1


(Homo sapiens (Human))		BDBM50150568
PNG
(CHEMBL183819 | Dimethyl-{3-[4-(3-phenyl-isoxazol-5...)
Show SMILES CN(C)CCCOc1ccc(cc1)-c1cc(no1)-c1ccccc1
Show InChI InChI=1S/C20H22N2O2/c1-22(2)13-6-14-23-18-11-9-17(10-12-18)20-15-19(21-24-20)16-7-4-3-5-8-16/h3-5,7-12,15H,6,13-14H2,1-2H3
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n/an/a 6.70E+3n/an/an/an/an/an/a



Johnson and Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibitory concentration against interleukin-8 receptor of human neutrophils by using [125I]-IL-8 (0.125 nM) as radioligand

Bioorg Med Chem Lett 14: 4307-11 (2004)


Article DOI: 10.1016/j.bmcl.2004.05.080
BindingDB Entry DOI: 10.7270/Q23F4P4M
More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 1


(Homo sapiens (Human))		BDBM50150570
PNG
(1-Methyl-4-[4-(5-phenyl-isoxazol-3-yl)-phenoxymeth...)
Show SMILES CN1CCC(COc2ccc(cc2)-c2cc(on2)-c2ccccc2)CC1
Show InChI InChI=1S/C22H24N2O2/c1-24-13-11-17(12-14-24)16-25-20-9-7-18(8-10-20)21-15-22(26-23-21)19-5-3-2-4-6-19/h2-10,15,17H,11-14,16H2,1H3
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n/an/a 7.60E+3n/an/an/an/an/an/a



Johnson and Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibitory concentration against interleukin-8 receptor of human neutrophils by using [125I]-IL-8 (0.125 nM) as radioligand

Bioorg Med Chem Lett 14: 4307-11 (2004)


Article DOI: 10.1016/j.bmcl.2004.05.080
BindingDB Entry DOI: 10.7270/Q23F4P4M
More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 1


(Homo sapiens (Human))		BDBM50150560
PNG
(CHEMBL184583 | {3-[5-(4-Chloro-phenyl)-isoxazol-3-...)
Show SMILES CN(C)COc1cccc(c1)-c1cc(on1)-c1ccc(Cl)cc1
Show InChI InChI=1S/C18H17ClN2O2/c1-21(2)12-22-16-5-3-4-14(10-16)17-11-18(23-20-17)13-6-8-15(19)9-7-13/h3-11H,12H2,1-2H3
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n/an/a 8.10E+3n/an/an/an/an/an/a



Johnson and Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibitory concentration against interleukin-8 receptor of human neutrophils by using [125I]-IL-8 (0.125 nM) as radioligand

Bioorg Med Chem Lett 14: 4307-11 (2004)


Article DOI: 10.1016/j.bmcl.2004.05.080
BindingDB Entry DOI: 10.7270/Q23F4P4M
More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 1


(Homo sapiens (Human))		BDBM50150565
PNG
(1-(2-{4-[5-(4-Chloro-phenyl)-isoxazol-3-yl]-phenox...)
Show SMILES CN1CCN(CCOc2ccc(cc2)-c2cc(on2)-c2ccc(Cl)cc2)CC1
Show InChI InChI=1S/C22H24ClN3O2/c1-25-10-12-26(13-11-25)14-15-27-20-8-4-17(5-9-20)21-16-22(28-24-21)18-2-6-19(23)7-3-18/h2-9,16H,10-15H2,1H3
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n/an/a 8.90E+3n/an/an/an/an/an/a



Johnson and Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibitory concentration against interleukin-8 receptor of human neutrophils by using [125I]-IL-8 (0.125 nM) as radioligand

Bioorg Med Chem Lett 14: 4307-11 (2004)


Article DOI: 10.1016/j.bmcl.2004.05.080
BindingDB Entry DOI: 10.7270/Q23F4P4M
More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 1


(Homo sapiens (Human))		BDBM50150571
PNG
(1-(3-{4-[3-(3-Chloro-phenyl)-isoxazol-5-yl]-phenox...)
Show SMILES CN1CCN(CCCOc2ccc(cc2)-c2cc(no2)-c2cccc(Cl)c2)CC1
Show InChI InChI=1S/C23H26ClN3O2/c1-26-11-13-27(14-12-26)10-3-15-28-21-8-6-18(7-9-21)23-17-22(25-29-23)19-4-2-5-20(24)16-19/h2,4-9,16-17H,3,10-15H2,1H3
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n/an/a 9.60E+3n/an/an/an/an/an/a



Johnson and Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibitory concentration against interleukin-8 receptor of human neutrophils by using [125I]-IL-8 (0.125 nM) as radioligand

Bioorg Med Chem Lett 14: 4307-11 (2004)


Article DOI: 10.1016/j.bmcl.2004.05.080
BindingDB Entry DOI: 10.7270/Q23F4P4M
More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 1


(Homo sapiens (Human))		BDBM50150557
PNG
(1-(3-{4-[3-(4-Fluoro-phenyl)-[1,2,4]oxadiazol-5-yl...)
Show SMILES CN1CCN(CCCOc2ccc(cc2)-c2nc(no2)-c2ccc(F)cc2)CC1
Show InChI InChI=1S/C22H25FN4O2/c1-26-12-14-27(15-13-26)11-2-16-28-20-9-5-18(6-10-20)22-24-21(25-29-22)17-3-7-19(23)8-4-17/h3-10H,2,11-16H2,1H3
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n/an/a 1.05E+4n/an/an/an/an/an/a



Johnson and Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibitory concentration against interleukin-8 receptor of human neutrophils by using [125I]-IL-8 (0.125 nM) as radioligand

Bioorg Med Chem Lett 14: 4307-11 (2004)


Article DOI: 10.1016/j.bmcl.2004.05.080
BindingDB Entry DOI: 10.7270/Q23F4P4M
More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 1


(Homo sapiens (Human))		BDBM50150564
PNG
(CHEMBL425882 | Dimethyl-[4-(5-phenyl-isoxazol-3-yl...)
Show SMILES CN(C)COc1ccc(cc1)-c1cc(on1)-c1ccccc1
Show InChI InChI=1S/C18H18N2O2/c1-20(2)13-21-16-10-8-14(9-11-16)17-12-18(22-19-17)15-6-4-3-5-7-15/h3-12H,13H2,1-2H3
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n/an/a 1.06E+4n/an/an/an/an/an/a



Johnson and Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibitory concentration against interleukin-8 receptor of human neutrophils by using [125I]-IL-8 (0.125 nM) as radioligand

Bioorg Med Chem Lett 14: 4307-11 (2004)


Article DOI: 10.1016/j.bmcl.2004.05.080
BindingDB Entry DOI: 10.7270/Q23F4P4M
More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 1


(Homo sapiens (Human))		BDBM50150575
PNG
(1-Methyl-4-[4-(5-pyridin-2-yl-isoxazol-3-yl)-pheno...)
Show SMILES CN1CCN(COc2ccc(cc2)-c2cc(on2)-c2ccccn2)CC1
Show InChI InChI=1S/C20H22N4O2/c1-23-10-12-24(13-11-23)15-25-17-7-5-16(6-8-17)19-14-20(26-22-19)18-4-2-3-9-21-18/h2-9,14H,10-13,15H2,1H3
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n/an/a 1.15E+4n/an/an/an/an/an/a



Johnson and Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibitory concentration against interleukin-8 receptor of human neutrophils by using [125I]-IL-8 (0.125 nM) as radioligand

Bioorg Med Chem Lett 14: 4307-11 (2004)


Article DOI: 10.1016/j.bmcl.2004.05.080
BindingDB Entry DOI: 10.7270/Q23F4P4M
More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 1


(Homo sapiens (Human))		BDBM50150562
PNG
(CHEMBL184401 | Dimethyl-{4-[5-(4-nitro-phenyl)-iso...)
Show SMILES CN(C)COc1ccc(cc1)-c1cc([o+][n-]1)-c1ccc(cc1)[N+]([O-])=O
Show InChI InChI=1S/C18H17N3O4/c1-20(2)12-24-16-9-5-13(6-10-16)17-11-18(25-19-17)14-3-7-15(8-4-14)21(22)23/h3-11H,12H2,1-2H3
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n/an/a 1.21E+4n/an/an/an/an/an/a



Johnson and Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibitory concentration against interleukin-8 receptor of human neutrophils by using [125I]-IL-8 (0.125 nM) as radioligand

Bioorg Med Chem Lett 14: 4307-11 (2004)


Article DOI: 10.1016/j.bmcl.2004.05.080
BindingDB Entry DOI: 10.7270/Q23F4P4M
More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 1


(Homo sapiens (Human))		BDBM50150576
PNG
(1-Methyl-4-(3-{4-[3-(4-phenoxy-phenyl)-isoxazol-5-...)
Show SMILES CN1CCN(CCCOc2ccc(cc2)-c2cc(no2)-c2ccc(Oc3ccccc3)cc2)CC1
Show InChI InChI=1S/C29H31N3O3/c1-31-17-19-32(20-18-31)16-5-21-33-25-12-10-24(11-13-25)29-22-28(30-35-29)23-8-14-27(15-9-23)34-26-6-3-2-4-7-26/h2-4,6-15,22H,5,16-21H2,1H3
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n/an/a 2.27E+4n/an/an/an/an/an/a



Johnson and Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibitory concentration against interleukin-8 receptor of human neutrophils by using [125I]-IL-8 (0.125 nM) as radioligand

Bioorg Med Chem Lett 14: 4307-11 (2004)


Article DOI: 10.1016/j.bmcl.2004.05.080
BindingDB Entry DOI: 10.7270/Q23F4P4M
More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 1


(Homo sapiens (Human))		BDBM50150554
PNG
(4-(3-{4-[3-(4-Chloro-phenyl)-[1,2,4]oxadiazol-5-yl...)
Show SMILES Clc1ccc(cc1)-c1noc(n1)-c1ccc(OCCCN2CCOCC2)cc1
Show InChI InChI=1S/C21H22ClN3O3/c22-18-6-2-16(3-7-18)20-23-21(28-24-20)17-4-8-19(9-5-17)27-13-1-10-25-11-14-26-15-12-25/h2-9H,1,10-15H2
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n/an/a>2.50E+4n/an/an/an/an/an/a



Johnson and Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibitory concentration against interleukin-8 receptor of human neutrophils by using [125I]-IL-8 (0.125 nM) as radioligand

Bioorg Med Chem Lett 14: 4307-11 (2004)


Article DOI: 10.1016/j.bmcl.2004.05.080
BindingDB Entry DOI: 10.7270/Q23F4P4M
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%