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PubMed code 15293998

Compile data set for download or QSAR
Found 25 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Steryl-sulfatase


(Homo sapiens (Human))		BDBM50135162
PNG
(CHEMBL147705 | Sulfamic acid 2-adamantan-1-yl-4-ox...)
Show SMILES NS(=O)(=O)Oc1ccc2oc(cc(=O)c2c1)C12CC3CC(CC(C3)C1)C2 |TLB:23:18:25:24.22.21,23:22:25:17.18.19,THB:21:20:17:24.22.23,21:22:17:25.20.19|
Show InChI InChI=1S/C19H21NO5S/c20-26(22,23)25-14-1-2-17-15(6-14)16(21)7-18(24-17)19-8-11-3-12(9-19)5-13(4-11)10-19/h1-2,6-7,11-13H,3-5,8-10H2,(H2,20,22,23)
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 190n/an/an/an/an/an/an/an/a



Novartis Institute for Biomedical Research Vienna

Curated by ChEMBL


Assay Description
Inhibitory activity against human steroid sulfatase

J Med Chem 47: 4268-76 (2004)


Article DOI: 10.1021/jm0407916
BindingDB Entry DOI: 10.7270/Q2XW4KK4
More data for this
Ligand-Target Pair
Steryl-sulfatase


(Homo sapiens (Human))		BDBM50118560
PNG
(CHEMBL262050 | Sulfamic acid 2-adamantan-1-yl-4-ox...)
Show SMILES NS(=O)(=O)Oc1ccc2sc(cc(=O)c2c1)C12CC3CC(CC(C3)C1)C2 |TLB:23:22:25:17.18.19,23:18:25:24.22.21,THB:21:22:17:25.20.19,21:20:17:24.22.23|
Show InChI InChI=1S/C19H21NO4S2/c20-26(22,23)24-14-1-2-17-15(6-14)16(21)7-18(25-17)19-8-11-3-12(9-19)5-13(4-11)10-19/h1-2,6-7,11-13H,3-5,8-10H2,(H2,20,22,23)
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 210n/an/an/an/an/an/an/an/a



Novartis Institute for Biomedical Research Vienna

Curated by ChEMBL


Assay Description
Inhibitory activity against human steroid sulfatase

J Med Chem 47: 4268-76 (2004)


Article DOI: 10.1021/jm0407916
BindingDB Entry DOI: 10.7270/Q2XW4KK4
More data for this
Ligand-Target Pair
Steryl-sulfatase


(Homo sapiens (Human))		BDBM50151142
PNG
(2-Adamantan-1-yl-4-oxo-4H-chromene-6-carboxylic ac...)
Show SMILES OC(=O)c1ccc2oc(cc(=O)c2c1)C12CC3CC(CC(C3)C1)C2 |TLB:21:20:23:15.16.17,21:16:23:22.20.19,17:18:22:15.16.21,THB:17:16:22:23.18.19|
Show InChI InChI=1S/C20H20O4/c21-16-7-18(24-17-2-1-14(19(22)23)6-15(16)17)20-8-11-3-12(9-20)5-13(4-11)10-20/h1-2,6-7,11-13H,3-5,8-10H2,(H,22,23)
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 500n/an/an/an/an/an/an/an/a



Novartis Institute for Biomedical Research Vienna

Curated by ChEMBL


Assay Description
Inhibitory activity against human steroid sulfatase

J Med Chem 47: 4268-76 (2004)


Article DOI: 10.1021/jm0407916
BindingDB Entry DOI: 10.7270/Q2XW4KK4
More data for this
Ligand-Target Pair
Steryl-sulfatase


(Homo sapiens (Human))		BDBM50151137
PNG
(2-Adamantan-1-yl-4-oxo-4H-thiochromene-6-carboxyli...)
Show SMILES OC(=O)c1ccc2sc(cc(=O)c2c1)C12CC3CC(CC(C3)C1)C2 |TLB:21:20:23:15.16.17,21:16:23:22.20.19,17:18:22:15.16.21,THB:17:16:22:23.18.19|
Show InChI InChI=1S/C20H20O3S/c21-16-7-18(24-17-2-1-14(19(22)23)6-15(16)17)20-8-11-3-12(9-20)5-13(4-11)10-20/h1-2,6-7,11-13H,3-5,8-10H2,(H,22,23)
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 530n/an/an/an/an/an/an/an/a



Novartis Institute for Biomedical Research Vienna

Curated by ChEMBL


Assay Description
Inhibitory activity against human steroid sulfatase

J Med Chem 47: 4268-76 (2004)


Article DOI: 10.1021/jm0407916
BindingDB Entry DOI: 10.7270/Q2XW4KK4
More data for this
Ligand-Target Pair
Steryl-sulfatase


(Homo sapiens (Human))		BDBM50134329
PNG
(CHEMBL122708 | Sulfamic acid (11R,12S,15S,16S)-13-...)
Show SMILES C[C@]12CC[C@H]3[C@@H](CCc4cc(OS(N)(=O)=O)ccc34)[C@@H]1CCC2=O
Show InChI InChI=1S/C18H23NO4S/c1-18-9-8-14-13-5-3-12(23-24(19,21)22)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-16H,2,4,6-9H2,1H3,(H2,19,21,22)/t14-,15-,16+,18+/m1/s1
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 670n/an/an/an/an/an/an/an/a



Novartis Institute for Biomedical Research Vienna

Curated by ChEMBL


Assay Description
Inhibitory activity against human steroid sulfatase

J Med Chem 47: 4268-76 (2004)


Article DOI: 10.1021/jm0407916
BindingDB Entry DOI: 10.7270/Q2XW4KK4
More data for this
Ligand-Target Pair
Steryl-sulfatase


(Homo sapiens (Human))		BDBM50151135
PNG
((2-Adamantan-1-yl-4-oxo-4H-chromen-6-yl)-oxo-aceti...)
Show SMILES OC(=O)C(=O)c1ccc2oc(cc(=O)c2c1)C12CC3CC(CC(C3)C1)C2 |TLB:23:22:25:17.18.19,23:18:25:24.22.21,19:20:24:17.18.23,THB:19:18:24:25.20.21|
Show InChI InChI=1S/C21H20O5/c22-16-7-18(21-8-11-3-12(9-21)5-13(4-11)10-21)26-17-2-1-14(6-15(16)17)19(23)20(24)25/h1-2,6-7,11-13H,3-5,8-10H2,(H,24,25)
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 2.20E+3n/an/an/an/an/an/an/an/a



Novartis Institute for Biomedical Research Vienna

Curated by ChEMBL


Assay Description
Inhibitory activity against human steroid sulfatase

J Med Chem 47: 4268-76 (2004)


Article DOI: 10.1021/jm0407916
BindingDB Entry DOI: 10.7270/Q2XW4KK4
More data for this
Ligand-Target Pair
Steryl-sulfatase


(Homo sapiens (Human))		BDBM50151140
PNG
(2-Adamantan-1-yl-6-(2-hydroxy-acetyl)-chromen-4-on...)
Show SMILES OCC(=O)c1ccc2oc(cc(=O)c2c1)C12CC3CC(CC(C3)C1)C2 |TLB:22:21:24:16.17.18,22:17:24:23.21.20,18:19:23:16.17.22,THB:18:17:23:24.19.20|
Show InChI InChI=1S/C21H22O4/c22-11-18(24)15-1-2-19-16(6-15)17(23)7-20(25-19)21-8-12-3-13(9-21)5-14(4-12)10-21/h1-2,6-7,12-14,22H,3-5,8-11H2
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 3.20E+3n/an/an/an/an/an/an/an/a



Novartis Institute for Biomedical Research Vienna

Curated by ChEMBL


Assay Description
Inhibitory activity against human steroid sulfatase

J Med Chem 47: 4268-76 (2004)


Article DOI: 10.1021/jm0407916
BindingDB Entry DOI: 10.7270/Q2XW4KK4
More data for this
Ligand-Target Pair
Steryl-sulfatase


(Homo sapiens (Human))		BDBM50151134
PNG
(2-Adamantan-1-yl-4-oxo-4H-chromene-6-carbaldehyde ...)
Show SMILES O=Cc1ccc2oc(cc(=O)c2c1)C12CC3CC(CC(C3)C1)C2 |TLB:16:17:21:14.15.20,THB:16:15:21:22.17.18,18:17:14:21.19.20,18:19:14:22.17.16|
Show InChI InChI=1S/C20H20O3/c21-11-12-1-2-18-16(6-12)17(22)7-19(23-18)20-8-13-3-14(9-20)5-15(4-13)10-20/h1-2,6-7,11,13-15H,3-5,8-10H2
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>2.00E+4n/an/an/an/an/an/an/an/a



Novartis Institute for Biomedical Research Vienna

Curated by ChEMBL


Assay Description
Inhibitory activity against human steroid sulfatase

J Med Chem 47: 4268-76 (2004)


Article DOI: 10.1021/jm0407916
BindingDB Entry DOI: 10.7270/Q2XW4KK4
More data for this
Ligand-Target Pair
Steryl-sulfatase


(Homo sapiens (Human))		BDBM50151141
PNG
(2-Adamantan-1-yl-6-hydroxymethyl-chromen-4-one | C...)
Show SMILES OCc1ccc2oc(cc(=O)c2c1)C12CC3CC(CC(C3)C1)C2 |TLB:16:17:21:14.15.20,THB:16:15:21:22.17.18,18:17:14:21.19.20,18:19:14:22.17.16|
Show InChI InChI=1S/C20H22O3/c21-11-12-1-2-18-16(6-12)17(22)7-19(23-18)20-8-13-3-14(9-20)5-15(4-13)10-20/h1-2,6-7,13-15,21H,3-5,8-11H2
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 3.20E+4n/an/an/an/an/an/an/an/a



Novartis Institute for Biomedical Research Vienna

Curated by ChEMBL


Assay Description
Inhibitory activity against human steroid sulfatase

J Med Chem 47: 4268-76 (2004)


Article DOI: 10.1021/jm0407916
BindingDB Entry DOI: 10.7270/Q2XW4KK4
More data for this
Ligand-Target Pair
Steryl-sulfatase


(Homo sapiens (Human))		BDBM50151136
PNG
(2-Adamantan-1-yl-4-oxo-4H-thiochromene-6-carbonitr...)
Show SMILES O=c1cc(sc2ccc(cc12)C#N)C12CC3CC(CC(C3)C1)C2 |TLB:16:17:21:14.15.20,THB:16:15:21:22.17.18,18:19:14:22.17.16,18:17:14:21.19.20|
Show InChI InChI=1S/C20H19NOS/c21-11-12-1-2-18-16(6-12)17(22)7-19(23-18)20-8-13-3-14(9-20)5-15(4-13)10-20/h1-2,6-7,13-15H,3-5,8-10H2
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>5.00E+4n/an/an/an/an/an/an/an/a



Novartis Institute for Biomedical Research Vienna

Curated by ChEMBL


Assay Description
Inhibitory activity against human steroid sulfatase

J Med Chem 47: 4268-76 (2004)


Article DOI: 10.1021/jm0407916
BindingDB Entry DOI: 10.7270/Q2XW4KK4
More data for this
Ligand-Target Pair
Steryl-sulfatase


(Homo sapiens (Human))		BDBM50151138
PNG
((2-Adamantan-1-yl-4-oxo-4H-chromen-6-yl)-acetic ac...)
Show SMILES OC(=O)Cc1ccc2oc(cc(=O)c2c1)C12CC3CC(CC(C3)C1)C2 |TLB:22:21:24:16.17.18,22:17:24:23.21.20,THB:20:19:16:23.21.22,20:21:16:24.19.18|
Show InChI InChI=1S/C21H22O4/c22-17-8-19(21-9-13-3-14(10-21)5-15(4-13)11-21)25-18-2-1-12(6-16(17)18)7-20(23)24/h1-2,6,8,13-15H,3-5,7,9-11H2,(H,23,24)
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>5.00E+4n/an/an/an/an/an/an/an/a



Novartis Institute for Biomedical Research Vienna

Curated by ChEMBL


Assay Description
Inhibitory activity against human steroid sulfatase

J Med Chem 47: 4268-76 (2004)


Article DOI: 10.1021/jm0407916
BindingDB Entry DOI: 10.7270/Q2XW4KK4
More data for this
Ligand-Target Pair
Steryl-sulfatase


(Homo sapiens (Human))		BDBM50151143
PNG
(2-Adamantan-1-yl-4-oxo-4H-chromene-6-carboxylic ac...)
Show SMILES NC(=O)c1ccc2oc(cc(=O)c2c1)C12CC3CC(CC(C3)C1)C2 |TLB:21:20:23:15.16.17,21:16:23:22.20.19,17:18:22:15.16.21,THB:17:16:22:23.18.19|
Show InChI InChI=1S/C20H21NO3/c21-19(23)14-1-2-17-15(6-14)16(22)7-18(24-17)20-8-11-3-12(9-20)5-13(4-11)10-20/h1-2,6-7,11-13H,3-5,8-10H2,(H2,21,23)
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>5.00E+4n/an/an/an/an/an/an/an/a



Novartis Institute for Biomedical Research Vienna

Curated by ChEMBL


Assay Description
Inhibitory activity against human steroid sulfatase

J Med Chem 47: 4268-76 (2004)


Article DOI: 10.1021/jm0407916
BindingDB Entry DOI: 10.7270/Q2XW4KK4
More data for this
Ligand-Target Pair
Steryl-sulfatase


(Homo sapiens (Human))		BDBM50151139
PNG
(2-Adamantan-1-yl-4-oxo-4H-chromene-6-carboxylic ac...)
Show SMILES COC(=O)c1ccc2oc(cc(=O)c2c1)C12CC3CC(CC(C3)C1)C2 |TLB:22:21:24:16.17.18,22:17:24:23.21.20,18:19:23:16.17.22,THB:18:17:23:24.19.20|
Show InChI InChI=1S/C21H22O4/c1-24-20(23)15-2-3-18-16(7-15)17(22)8-19(25-18)21-9-12-4-13(10-21)6-14(5-12)11-21/h2-3,7-8,12-14H,4-6,9-11H2,1H3
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>5.00E+4n/an/an/an/an/an/an/an/a



Novartis Institute for Biomedical Research Vienna

Curated by ChEMBL


Assay Description
Inhibitory activity against human steroid sulfatase

J Med Chem 47: 4268-76 (2004)


Article DOI: 10.1021/jm0407916
BindingDB Entry DOI: 10.7270/Q2XW4KK4
More data for this
Ligand-Target Pair
Steryl-sulfatase


(Homo sapiens (Human))		BDBM50135162
PNG
(CHEMBL147705 | Sulfamic acid 2-adamantan-1-yl-4-ox...)
Show SMILES NS(=O)(=O)Oc1ccc2oc(cc(=O)c2c1)C12CC3CC(CC(C3)C1)C2 |TLB:23:18:25:24.22.21,23:22:25:17.18.19,THB:21:20:17:24.22.23,21:22:17:25.20.19|
Show InChI InChI=1S/C19H21NO5S/c20-26(22,23)25-14-1-2-17-15(6-14)16(21)7-18(24-17)19-8-11-3-12(9-19)5-13(4-11)10-19/h1-2,6-7,11-13H,3-5,8-10H2,(H2,20,22,23)
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n/an/a 20n/an/an/an/an/an/a



Novartis Institute for Biomedical Research Vienna

Curated by ChEMBL


Assay Description
Inhibitory activity against human steroid sulfatase over-expressed in CHO cells

J Med Chem 47: 4268-76 (2004)


Article DOI: 10.1021/jm0407916
BindingDB Entry DOI: 10.7270/Q2XW4KK4
More data for this
Ligand-Target Pair
Steryl-sulfatase


(Homo sapiens (Human))		BDBM50118560
PNG
(CHEMBL262050 | Sulfamic acid 2-adamantan-1-yl-4-ox...)
Show SMILES NS(=O)(=O)Oc1ccc2sc(cc(=O)c2c1)C12CC3CC(CC(C3)C1)C2 |TLB:23:22:25:17.18.19,23:18:25:24.22.21,THB:21:22:17:25.20.19,21:20:17:24.22.23|
Show InChI InChI=1S/C19H21NO4S2/c20-26(22,23)24-14-1-2-17-15(6-14)16(21)7-18(25-17)19-8-11-3-12(9-19)5-13(4-11)10-19/h1-2,6-7,11-13H,3-5,8-10H2,(H2,20,22,23)
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n/an/a 20n/an/an/an/an/an/a



Novartis Institute for Biomedical Research Vienna

Curated by ChEMBL


Assay Description
Inhibitory activity against human steroid sulfatase over-expressed in CHO cells

J Med Chem 47: 4268-76 (2004)


Article DOI: 10.1021/jm0407916
BindingDB Entry DOI: 10.7270/Q2XW4KK4
More data for this
Ligand-Target Pair
Steryl-sulfatase


(Homo sapiens (Human))		BDBM50134329
PNG
(CHEMBL122708 | Sulfamic acid (11R,12S,15S,16S)-13-...)
Show SMILES C[C@]12CC[C@H]3[C@@H](CCc4cc(OS(N)(=O)=O)ccc34)[C@@H]1CCC2=O
Show InChI InChI=1S/C18H23NO4S/c1-18-9-8-14-13-5-3-12(23-24(19,21)22)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-16H,2,4,6-9H2,1H3,(H2,19,21,22)/t14-,15-,16+,18+/m1/s1
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n/an/a 20n/an/an/an/an/an/a



Novartis Institute for Biomedical Research Vienna

Curated by ChEMBL


Assay Description
Inhibitory activity against human steroid sulfatase over-expressed in CHO cells

J Med Chem 47: 4268-76 (2004)


Article DOI: 10.1021/jm0407916
BindingDB Entry DOI: 10.7270/Q2XW4KK4
More data for this
Ligand-Target Pair
Steryl-sulfatase


(Homo sapiens (Human))		BDBM50151137
PNG
(2-Adamantan-1-yl-4-oxo-4H-thiochromene-6-carboxyli...)
Show SMILES OC(=O)c1ccc2sc(cc(=O)c2c1)C12CC3CC(CC(C3)C1)C2 |TLB:21:20:23:15.16.17,21:16:23:22.20.19,17:18:22:15.16.21,THB:17:16:22:23.18.19|
Show InChI InChI=1S/C20H20O3S/c21-16-7-18(24-17-2-1-14(19(22)23)6-15(16)17)20-8-11-3-12(9-20)5-13(4-11)10-20/h1-2,6-7,11-13H,3-5,8-10H2,(H,22,23)
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n/an/a 180n/an/an/an/an/an/a



Novartis Institute for Biomedical Research Vienna

Curated by ChEMBL


Assay Description
Inhibitory activity against human steroid sulfatase over-expressed in CHO cells

J Med Chem 47: 4268-76 (2004)


Article DOI: 10.1021/jm0407916
BindingDB Entry DOI: 10.7270/Q2XW4KK4
More data for this
Ligand-Target Pair
Steryl-sulfatase


(Homo sapiens (Human))		BDBM50151142
PNG
(2-Adamantan-1-yl-4-oxo-4H-chromene-6-carboxylic ac...)
Show SMILES OC(=O)c1ccc2oc(cc(=O)c2c1)C12CC3CC(CC(C3)C1)C2 |TLB:21:20:23:15.16.17,21:16:23:22.20.19,17:18:22:15.16.21,THB:17:16:22:23.18.19|
Show InChI InChI=1S/C20H20O4/c21-16-7-18(24-17-2-1-14(19(22)23)6-15(16)17)20-8-11-3-12(9-20)5-13(4-11)10-20/h1-2,6-7,11-13H,3-5,8-10H2,(H,22,23)
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n/an/a 9.40E+3n/an/an/an/an/an/a



Novartis Institute for Biomedical Research Vienna

Curated by ChEMBL


Assay Description
Inhibitory activity against human steroid sulfatase over-expressed in CHO cells

J Med Chem 47: 4268-76 (2004)


Article DOI: 10.1021/jm0407916
BindingDB Entry DOI: 10.7270/Q2XW4KK4
More data for this
Ligand-Target Pair
Steryl-sulfatase


(Homo sapiens (Human))		BDBM50151135
PNG
((2-Adamantan-1-yl-4-oxo-4H-chromen-6-yl)-oxo-aceti...)
Show SMILES OC(=O)C(=O)c1ccc2oc(cc(=O)c2c1)C12CC3CC(CC(C3)C1)C2 |TLB:23:22:25:17.18.19,23:18:25:24.22.21,19:20:24:17.18.23,THB:19:18:24:25.20.21|
Show InChI InChI=1S/C21H20O5/c22-16-7-18(21-8-11-3-12(9-21)5-13(4-11)10-21)26-17-2-1-14(6-15(16)17)19(23)20(24)25/h1-2,6-7,11-13H,3-5,8-10H2,(H,24,25)
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n/an/a 1.23E+4n/an/an/an/an/an/a



Novartis Institute for Biomedical Research Vienna

Curated by ChEMBL


Assay Description
Inhibitory activity against human steroid sulfatase over-expressed in CHO cells

J Med Chem 47: 4268-76 (2004)


Article DOI: 10.1021/jm0407916
BindingDB Entry DOI: 10.7270/Q2XW4KK4
More data for this
Ligand-Target Pair
Steryl-sulfatase


(Homo sapiens (Human))		BDBM50151140
PNG
(2-Adamantan-1-yl-6-(2-hydroxy-acetyl)-chromen-4-on...)
Show SMILES OCC(=O)c1ccc2oc(cc(=O)c2c1)C12CC3CC(CC(C3)C1)C2 |TLB:22:21:24:16.17.18,22:17:24:23.21.20,18:19:23:16.17.22,THB:18:17:23:24.19.20|
Show InChI InChI=1S/C21H22O4/c22-11-18(24)15-1-2-19-16(6-15)17(23)7-20(25-19)21-8-12-3-13(9-21)5-14(4-12)10-21/h1-2,6-7,12-14,22H,3-5,8-11H2
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n/an/a>3.00E+4n/an/an/an/an/an/a



Novartis Institute for Biomedical Research Vienna

Curated by ChEMBL


Assay Description
Inhibitory activity against human steroid sulfatase over-expressed in CHO cells

J Med Chem 47: 4268-76 (2004)


Article DOI: 10.1021/jm0407916
BindingDB Entry DOI: 10.7270/Q2XW4KK4
More data for this
Ligand-Target Pair
Steryl-sulfatase


(Homo sapiens (Human))		BDBM50151136
PNG
(2-Adamantan-1-yl-4-oxo-4H-thiochromene-6-carbonitr...)
Show SMILES O=c1cc(sc2ccc(cc12)C#N)C12CC3CC(CC(C3)C1)C2 |TLB:16:17:21:14.15.20,THB:16:15:21:22.17.18,18:19:14:22.17.16,18:17:14:21.19.20|
Show InChI InChI=1S/C20H19NOS/c21-11-12-1-2-18-16(6-12)17(22)7-19(23-18)20-8-13-3-14(9-20)5-15(4-13)10-20/h1-2,6-7,13-15H,3-5,8-10H2
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n/an/a>3.00E+4n/an/an/an/an/an/a



Novartis Institute for Biomedical Research Vienna

Curated by ChEMBL


Assay Description
Inhibitory activity against human steroid sulfatase over-expressed in CHO cells

J Med Chem 47: 4268-76 (2004)


Article DOI: 10.1021/jm0407916
BindingDB Entry DOI: 10.7270/Q2XW4KK4
More data for this
Ligand-Target Pair
Steryl-sulfatase


(Homo sapiens (Human))		BDBM50151143
PNG
(2-Adamantan-1-yl-4-oxo-4H-chromene-6-carboxylic ac...)
Show SMILES NC(=O)c1ccc2oc(cc(=O)c2c1)C12CC3CC(CC(C3)C1)C2 |TLB:21:20:23:15.16.17,21:16:23:22.20.19,17:18:22:15.16.21,THB:17:16:22:23.18.19|
Show InChI InChI=1S/C20H21NO3/c21-19(23)14-1-2-17-15(6-14)16(22)7-18(24-17)20-8-11-3-12(9-20)5-13(4-11)10-20/h1-2,6-7,11-13H,3-5,8-10H2,(H2,21,23)
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n/an/a>3.00E+4n/an/an/an/an/an/a



Novartis Institute for Biomedical Research Vienna

Curated by ChEMBL


Assay Description
Inhibitory activity against human steroid sulfatase over-expressed in CHO cells

J Med Chem 47: 4268-76 (2004)


Article DOI: 10.1021/jm0407916
BindingDB Entry DOI: 10.7270/Q2XW4KK4
More data for this
Ligand-Target Pair
Steryl-sulfatase


(Homo sapiens (Human))		BDBM50151139
PNG
(2-Adamantan-1-yl-4-oxo-4H-chromene-6-carboxylic ac...)
Show SMILES COC(=O)c1ccc2oc(cc(=O)c2c1)C12CC3CC(CC(C3)C1)C2 |TLB:22:21:24:16.17.18,22:17:24:23.21.20,18:19:23:16.17.22,THB:18:17:23:24.19.20|
Show InChI InChI=1S/C21H22O4/c1-24-20(23)15-2-3-18-16(7-15)17(22)8-19(25-18)21-9-12-4-13(10-21)6-14(5-12)11-21/h2-3,7-8,12-14H,4-6,9-11H2,1H3
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n/an/a>3.00E+4n/an/an/an/an/an/a



Novartis Institute for Biomedical Research Vienna

Curated by ChEMBL


Assay Description
Inhibitory activity against human steroid sulfatase over-expressed in CHO cells

J Med Chem 47: 4268-76 (2004)


Article DOI: 10.1021/jm0407916
BindingDB Entry DOI: 10.7270/Q2XW4KK4
More data for this
Ligand-Target Pair
Steryl-sulfatase


(Homo sapiens (Human))		BDBM50151138
PNG
((2-Adamantan-1-yl-4-oxo-4H-chromen-6-yl)-acetic ac...)
Show SMILES OC(=O)Cc1ccc2oc(cc(=O)c2c1)C12CC3CC(CC(C3)C1)C2 |TLB:22:21:24:16.17.18,22:17:24:23.21.20,THB:20:19:16:23.21.22,20:21:16:24.19.18|
Show InChI InChI=1S/C21H22O4/c22-17-8-19(21-9-13-3-14(10-21)5-15(4-13)11-21)25-18-2-1-12(6-16(17)18)7-20(23)24/h1-2,6,8,13-15H,3-5,7,9-11H2,(H,23,24)
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n/an/a>3.00E+4n/an/an/an/an/an/a



Novartis Institute for Biomedical Research Vienna

Curated by ChEMBL


Assay Description
Inhibitory activity against human steroid sulfatase over-expressed in CHO cells

J Med Chem 47: 4268-76 (2004)


Article DOI: 10.1021/jm0407916
BindingDB Entry DOI: 10.7270/Q2XW4KK4
More data for this
Ligand-Target Pair
Steryl-sulfatase


(Homo sapiens (Human))		BDBM50151134
PNG
(2-Adamantan-1-yl-4-oxo-4H-chromene-6-carbaldehyde ...)
Show SMILES O=Cc1ccc2oc(cc(=O)c2c1)C12CC3CC(CC(C3)C1)C2 |TLB:16:17:21:14.15.20,THB:16:15:21:22.17.18,18:17:14:21.19.20,18:19:14:22.17.16|
Show InChI InChI=1S/C20H20O3/c21-11-12-1-2-18-16(6-12)17(22)7-19(23-18)20-8-13-3-14(9-20)5-15(4-13)10-20/h1-2,6-7,11,13-15H,3-5,8-10H2
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n/an/a>3.00E+4n/an/an/an/an/an/a



Novartis Institute for Biomedical Research Vienna

Curated by ChEMBL


Assay Description
Inhibitory activity against human steroid sulfatase over-expressed in CHO cells

J Med Chem 47: 4268-76 (2004)


Article DOI: 10.1021/jm0407916
BindingDB Entry DOI: 10.7270/Q2XW4KK4
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%