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PubMed code 15566287

Compile data set for download or QSAR
Found 106 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Alpha-2A adrenergic receptor


(Homo sapiens (Human))		BDBM50002903
PNG
(CHEMBL223836)
Show SMILES CC(Oc1ccccc1-c1cccc(F)c1)C1=NCCN1 |t:18|
Show InChI InChI=1S/C17H17FN2O/c1-12(17-19-9-10-20-17)21-16-8-3-2-7-15(16)13-5-4-6-14(18)11-13/h2-8,11-12H,9-10H2,1H3,(H,19,20)
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 15n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Camerino

Curated by ChEMBL


Assay Description
Displacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cells

J Med Chem 47: 6160-73 (2004)


Article DOI: 10.1021/jm0408215
BindingDB Entry DOI: 10.7270/Q2B27Z13
More data for this
Ligand-Target Pair
Alpha-2C adrenergic receptor


(Homo sapiens (Human))		BDBM50002903
PNG
(CHEMBL223836)
Show SMILES CC(Oc1ccccc1-c1cccc(F)c1)C1=NCCN1 |t:18|
Show InChI InChI=1S/C17H17FN2O/c1-12(17-19-9-10-20-17)21-16-8-3-2-7-15(16)13-5-4-6-14(18)11-13/h2-8,11-12H,9-10H2,1H3,(H,19,20)
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 17n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Camerino

Curated by ChEMBL


Assay Description
Displacement of [3H]RX821002 from human adrenergic Alpha-2C receptor expressed in CHO cells

J Med Chem 47: 6160-73 (2004)


Article DOI: 10.1021/jm0408215
BindingDB Entry DOI: 10.7270/Q2B27Z13
More data for this
Ligand-Target Pair
Alpha-2A adrenergic receptor


(Homo sapiens (Human))		BDBM50476178
PNG
(CHEMBL223829)
Show SMILES CC(Oc1ccccc1-c1cccs1)C1=NCCN1 |t:16|
Show InChI InChI=1S/C15H16N2OS/c1-11(15-16-8-9-17-15)18-13-6-3-2-5-12(13)14-7-4-10-19-14/h2-7,10-11H,8-9H2,1H3,(H,16,17)
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 17n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Camerino

Curated by ChEMBL


Assay Description
Displacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cells

J Med Chem 47: 6160-73 (2004)


Article DOI: 10.1021/jm0408215
BindingDB Entry DOI: 10.7270/Q2B27Z13
More data for this
Ligand-Target Pair
Alpha-2C adrenergic receptor


(Homo sapiens (Human))		BDBM50417350
PNG
(CHEMBL374584)
Show SMILES CC(Oc1ccccc1-c1cccc(O)c1)C1=NCCN1 |t:18|
Show InChI InChI=1S/C17H18N2O2/c1-12(17-18-9-10-19-17)21-16-8-3-2-7-15(16)13-5-4-6-14(20)11-13/h2-8,11-12,20H,9-10H2,1H3,(H,18,19)
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 18n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Camerino

Curated by ChEMBL


Assay Description
Displacement of [3H]RX821002 from human adrenergic Alpha-2C receptor expressed in CHO cells

J Med Chem 47: 6160-73 (2004)


Article DOI: 10.1021/jm0408215
BindingDB Entry DOI: 10.7270/Q2B27Z13
More data for this
Ligand-Target Pair
Alpha-2A adrenergic receptor


(Homo sapiens (Human))		BDBM50417350
PNG
(CHEMBL374584)
Show SMILES CC(Oc1ccccc1-c1cccc(O)c1)C1=NCCN1 |t:18|
Show InChI InChI=1S/C17H18N2O2/c1-12(17-18-9-10-19-17)21-16-8-3-2-7-15(16)13-5-4-6-14(20)11-13/h2-8,11-12,20H,9-10H2,1H3,(H,18,19)
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 28n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Camerino

Curated by ChEMBL


Assay Description
Displacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cells

J Med Chem 47: 6160-73 (2004)


Article DOI: 10.1021/jm0408215
BindingDB Entry DOI: 10.7270/Q2B27Z13
More data for this
Ligand-Target Pair
Alpha-2A adrenergic receptor


(Homo sapiens (Human))		BDBM50476174
PNG
(CHEMBL222798)
Show SMILES CC(Oc1ccccc1-c1ccc(O)cc1)C1=NCCN1 |t:18|
Show InChI InChI=1S/C17H18N2O2/c1-12(17-18-10-11-19-17)21-16-5-3-2-4-15(16)13-6-8-14(20)9-7-13/h2-9,12,20H,10-11H2,1H3,(H,18,19)
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 34n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Camerino

Curated by ChEMBL


Assay Description
Displacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cells

J Med Chem 47: 6160-73 (2004)


Article DOI: 10.1021/jm0408215
BindingDB Entry DOI: 10.7270/Q2B27Z13
More data for this
Ligand-Target Pair
Alpha-2A adrenergic receptor


(Homo sapiens (Human))		BDBM50476185
PNG
(CHEMBL222371)
Show SMILES CC(Oc1ccccc1-c1cccc(N)c1)C1=NCCN1 |t:18|
Show InChI InChI=1S/C17H19N3O/c1-12(17-19-9-10-20-17)21-16-8-3-2-7-15(16)13-5-4-6-14(18)11-13/h2-8,11-12H,9-10,18H2,1H3,(H,19,20)
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 37n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Camerino

Curated by ChEMBL


Assay Description
Displacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cells

J Med Chem 47: 6160-73 (2004)


Article DOI: 10.1021/jm0408215
BindingDB Entry DOI: 10.7270/Q2B27Z13
More data for this
Ligand-Target Pair
Alpha-2A adrenergic receptor


(Homo sapiens (Human))		BDBM50476175
PNG
(CHEMBL426900)
Show SMILES CC(Oc1ccccc1-c1ccc(C)cc1)C1=NCCN1 |t:18|
Show InChI InChI=1S/C18H20N2O/c1-13-7-9-15(10-8-13)16-5-3-4-6-17(16)21-14(2)18-19-11-12-20-18/h3-10,14H,11-12H2,1-2H3,(H,19,20)
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 42n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Camerino

Curated by ChEMBL


Assay Description
Displacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cells

J Med Chem 47: 6160-73 (2004)


Article DOI: 10.1021/jm0408215
BindingDB Entry DOI: 10.7270/Q2B27Z13
More data for this
Ligand-Target Pair
Alpha-2A adrenergic receptor


(Homo sapiens (Human))		BDBM50417347
PNG
(CHEMBL385310)
Show SMILES CC(Oc1ccccc1-c1ccsc1)C1=NCCN1 |t:16|
Show InChI InChI=1S/C15H16N2OS/c1-11(15-16-7-8-17-15)18-14-5-3-2-4-13(14)12-6-9-19-10-12/h2-6,9-11H,7-8H2,1H3,(H,16,17)
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 46n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Camerino

Curated by ChEMBL


Assay Description
Displacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cells

J Med Chem 47: 6160-73 (2004)


Article DOI: 10.1021/jm0408215
BindingDB Entry DOI: 10.7270/Q2B27Z13
More data for this
Ligand-Target Pair
Alpha-2A adrenergic receptor


(Homo sapiens (Human))		BDBM50476188
PNG
(CHEMBL223830)
Show SMILES CC(Oc1ccccc1-c1ccccc1C)C1=NCCN1 |t:18|
Show InChI InChI=1S/C18H20N2O/c1-13-7-3-4-8-15(13)16-9-5-6-10-17(16)21-14(2)18-19-11-12-20-18/h3-10,14H,11-12H2,1-2H3,(H,19,20)
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 47n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Camerino

Curated by ChEMBL


Assay Description
Displacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cells

J Med Chem 47: 6160-73 (2004)


Article DOI: 10.1021/jm0408215
BindingDB Entry DOI: 10.7270/Q2B27Z13
More data for this
Ligand-Target Pair
Alpha-2A adrenergic receptor


(Homo sapiens (Human))		BDBM50412250
PNG
(CHEMBL128168)
Show SMILES CC(Oc1ccccc1-c1ccccc1)C1=NCCN1 |t:17|
Show InChI InChI=1S/C17H18N2O/c1-13(17-18-11-12-19-17)20-16-10-6-5-9-15(16)14-7-3-2-4-8-14/h2-10,13H,11-12H2,1H3,(H,18,19)
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 48n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Camerino

Curated by ChEMBL


Assay Description
Displacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cells

J Med Chem 47: 6160-73 (2004)


Article DOI: 10.1021/jm0408215
BindingDB Entry DOI: 10.7270/Q2B27Z13
More data for this
Ligand-Target Pair
Alpha-2A adrenergic receptor


(Homo sapiens (Human))		BDBM50476173
PNG
(CHEMBL222973)
Show SMILES CC(Oc1ccccc1-c1cccc(C)c1)C1=NCCN1 |t:18|
Show InChI InChI=1S/C18H20N2O/c1-13-6-5-7-15(12-13)16-8-3-4-9-17(16)21-14(2)18-19-10-11-20-18/h3-9,12,14H,10-11H2,1-2H3,(H,19,20)
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 51n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Camerino

Curated by ChEMBL


Assay Description
Displacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cells

J Med Chem 47: 6160-73 (2004)


Article DOI: 10.1021/jm0408215
BindingDB Entry DOI: 10.7270/Q2B27Z13
More data for this
Ligand-Target Pair
Alpha-2A adrenergic receptor


(Homo sapiens (Human))		BDBM50002904
PNG
(CHEMBL222928)
Show SMILES CC(Oc1ccccc1-c1cccc(c1)[N+]([O-])=O)C1=NCCN1 |t:20|
Show InChI InChI=1S/C17H17N3O3/c1-12(17-18-9-10-19-17)23-16-8-3-2-7-15(16)13-5-4-6-14(11-13)20(21)22/h2-8,11-12H,9-10H2,1H3,(H,18,19)
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 60n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Camerino

Curated by ChEMBL


Assay Description
Displacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cells

J Med Chem 47: 6160-73 (2004)


Article DOI: 10.1021/jm0408215
BindingDB Entry DOI: 10.7270/Q2B27Z13
More data for this
Ligand-Target Pair
Alpha-2C adrenergic receptor


(Homo sapiens (Human))		BDBM50002905
PNG
(CHEMBL373535)
Show SMILES CC(Oc1ccccc1-c1cccnc1)C1=NCCN1 |t:17|
Show InChI InChI=1S/C16H17N3O/c1-12(16-18-9-10-19-16)20-15-7-3-2-6-14(15)13-5-4-8-17-11-13/h2-8,11-12H,9-10H2,1H3,(H,18,19)
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 65n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Camerino

Curated by ChEMBL


Assay Description
Displacement of [3H]RX821002 from human adrenergic Alpha-2C receptor expressed in CHO cells

J Med Chem 47: 6160-73 (2004)


Article DOI: 10.1021/jm0408215
BindingDB Entry DOI: 10.7270/Q2B27Z13
More data for this
Ligand-Target Pair
Alpha-2C adrenergic receptor


(Homo sapiens (Human))		BDBM50476178
PNG
(CHEMBL223829)
Show SMILES CC(Oc1ccccc1-c1cccs1)C1=NCCN1 |t:16|
Show InChI InChI=1S/C15H16N2OS/c1-11(15-16-8-9-17-15)18-13-6-3-2-5-12(13)14-7-4-10-19-14/h2-7,10-11H,8-9H2,1H3,(H,16,17)
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 72n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Camerino

Curated by ChEMBL


Assay Description
Displacement of [3H]RX821002 from human adrenergic Alpha-2C receptor expressed in CHO cells

J Med Chem 47: 6160-73 (2004)


Article DOI: 10.1021/jm0408215
BindingDB Entry DOI: 10.7270/Q2B27Z13
More data for this
Ligand-Target Pair
Alpha-2A adrenergic receptor


(Homo sapiens (Human))		BDBM50473619
PNG
(CHEMBL130884)
Show SMILES CC(Nc1ccccc1-c1ccccc1)C1=NCCN1 |t:17|
Show InChI InChI=1S/C17H19N3/c1-13(17-18-11-12-19-17)20-16-10-6-5-9-15(16)14-7-3-2-4-8-14/h2-10,13,20H,11-12H2,1H3,(H,18,19)
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 91n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Camerino

Curated by ChEMBL


Assay Description
Displacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cells

J Med Chem 47: 6160-73 (2004)


Article DOI: 10.1021/jm0408215
BindingDB Entry DOI: 10.7270/Q2B27Z13
More data for this
Ligand-Target Pair
Alpha-2A adrenergic receptor


(Homo sapiens (Human))		BDBM50476187
PNG
(CHEMBL221523)
Show SMILES CC(Oc1ccccc1-c1ccc(cc1)[N+]([O-])=O)C1=NCCN1 |t:20|
Show InChI InChI=1S/C17H17N3O3/c1-12(17-18-10-11-19-17)23-16-5-3-2-4-15(16)13-6-8-14(9-7-13)20(21)22/h2-9,12H,10-11H2,1H3,(H,18,19)
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 123n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Camerino

Curated by ChEMBL


Assay Description
Displacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cells

J Med Chem 47: 6160-73 (2004)


Article DOI: 10.1021/jm0408215
BindingDB Entry DOI: 10.7270/Q2B27Z13
More data for this
Ligand-Target Pair
Nischarin


(Homo sapiens (Human))		BDBM50412250
PNG
(CHEMBL128168)
Show SMILES CC(Oc1ccccc1-c1ccccc1)C1=NCCN1 |t:17|
Show InChI InChI=1S/C17H18N2O/c1-13(17-18-11-12-19-17)20-16-10-6-5-9-15(16)14-7-3-2-4-8-14/h2-10,13H,11-12H2,1H3,(H,18,19)
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 126n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Camerino

Curated by ChEMBL


Assay Description
Binding affinity to imidazoline receptor 1

J Med Chem 47: 6160-73 (2004)


Article DOI: 10.1021/jm0408215
BindingDB Entry DOI: 10.7270/Q2B27Z13
More data for this
Ligand-Target Pair
Alpha-2C adrenergic receptor


(Homo sapiens (Human))		BDBM50417347
PNG
(CHEMBL385310)
Show SMILES CC(Oc1ccccc1-c1ccsc1)C1=NCCN1 |t:16|
Show InChI InChI=1S/C15H16N2OS/c1-11(15-16-7-8-17-15)18-14-5-3-2-4-13(14)12-6-9-19-10-12/h2-6,9-11H,7-8H2,1H3,(H,16,17)
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 132n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Camerino

Curated by ChEMBL


Assay Description
Displacement of [3H]RX821002 from human adrenergic Alpha-2C receptor expressed in CHO cells

J Med Chem 47: 6160-73 (2004)


Article DOI: 10.1021/jm0408215
BindingDB Entry DOI: 10.7270/Q2B27Z13
More data for this
Ligand-Target Pair
Alpha-2A adrenergic receptor


(Homo sapiens (Human))		BDBM50002905
PNG
(CHEMBL373535)
Show SMILES CC(Oc1ccccc1-c1cccnc1)C1=NCCN1 |t:17|
Show InChI InChI=1S/C16H17N3O/c1-12(16-18-9-10-19-16)20-15-7-3-2-6-14(15)13-5-4-8-17-11-13/h2-8,11-12H,9-10H2,1H3,(H,18,19)
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 138n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Camerino

Curated by ChEMBL


Assay Description
Displacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cells

J Med Chem 47: 6160-73 (2004)


Article DOI: 10.1021/jm0408215
BindingDB Entry DOI: 10.7270/Q2B27Z13
More data for this
Ligand-Target Pair
Alpha-2A adrenergic receptor


(Homo sapiens (Human))		BDBM50476177
PNG
(CHEMBL222138)
Show SMILES CC(Oc1ccccc1-c1ccccc1[N+]([O-])=O)C1=NCCN1 |t:20|
Show InChI InChI=1S/C17H17N3O3/c1-12(17-18-10-11-19-17)23-16-9-5-3-7-14(16)13-6-2-4-8-15(13)20(21)22/h2-9,12H,10-11H2,1H3,(H,18,19)
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 174n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Camerino

Curated by ChEMBL


Assay Description
Displacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cells

J Med Chem 47: 6160-73 (2004)


Article DOI: 10.1021/jm0408215
BindingDB Entry DOI: 10.7270/Q2B27Z13
More data for this
Ligand-Target Pair
Alpha-2C adrenergic receptor


(Homo sapiens (Human))		BDBM50412250
PNG
(CHEMBL128168)
Show SMILES CC(Oc1ccccc1-c1ccccc1)C1=NCCN1 |t:17|
Show InChI InChI=1S/C17H18N2O/c1-13(17-18-11-12-19-17)20-16-10-6-5-9-15(16)14-7-3-2-4-8-14/h2-10,13H,11-12H2,1H3,(H,18,19)
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 200n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Camerino

Curated by ChEMBL


Assay Description
Displacement of [3H]RX821002 from human adrenergic Alpha-2C receptor expressed in CHO cells

J Med Chem 47: 6160-73 (2004)


Article DOI: 10.1021/jm0408215
BindingDB Entry DOI: 10.7270/Q2B27Z13
More data for this
Ligand-Target Pair
Alpha-2B adrenergic receptor


(Homo sapiens (Human))		BDBM50476178
PNG
(CHEMBL223829)
Show SMILES CC(Oc1ccccc1-c1cccs1)C1=NCCN1 |t:16|
Show InChI InChI=1S/C15H16N2OS/c1-11(15-16-8-9-17-15)18-13-6-3-2-5-12(13)14-7-4-10-19-14/h2-7,10-11H,8-9H2,1H3,(H,16,17)
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 214n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Camerino

Curated by ChEMBL


Assay Description
Displacement of [3H]RX821002 from human adrenergic alpha-2B receptor expressed in CHO cells

J Med Chem 47: 6160-73 (2004)


Article DOI: 10.1021/jm0408215
BindingDB Entry DOI: 10.7270/Q2B27Z13
More data for this
Ligand-Target Pair
Alpha-2C adrenergic receptor


(Homo sapiens (Human))		BDBM50476188
PNG
(CHEMBL223830)
Show SMILES CC(Oc1ccccc1-c1ccccc1C)C1=NCCN1 |t:18|
Show InChI InChI=1S/C18H20N2O/c1-13-7-3-4-8-15(13)16-9-5-6-10-17(16)21-14(2)18-19-11-12-20-18/h3-10,14H,11-12H2,1-2H3,(H,19,20)
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 234n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Camerino

Curated by ChEMBL


Assay Description
Displacement of [3H]RX821002 from human adrenergic Alpha-2C receptor expressed in CHO cells

J Med Chem 47: 6160-73 (2004)


Article DOI: 10.1021/jm0408215
BindingDB Entry DOI: 10.7270/Q2B27Z13
More data for this
Ligand-Target Pair
Alpha-2C adrenergic receptor


(Homo sapiens (Human))		BDBM50002904
PNG
(CHEMBL222928)
Show SMILES CC(Oc1ccccc1-c1cccc(c1)[N+]([O-])=O)C1=NCCN1 |t:20|
Show InChI InChI=1S/C17H17N3O3/c1-12(17-18-9-10-19-17)23-16-8-3-2-7-15(16)13-5-4-6-14(11-13)20(21)22/h2-8,11-12H,9-10H2,1H3,(H,18,19)
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 234n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Camerino

Curated by ChEMBL


Assay Description
Displacement of [3H]RX821002 from human adrenergic Alpha-2C receptor expressed in CHO cells

J Med Chem 47: 6160-73 (2004)


Article DOI: 10.1021/jm0408215
BindingDB Entry DOI: 10.7270/Q2B27Z13
More data for this
Ligand-Target Pair
Alpha-2C adrenergic receptor


(Homo sapiens (Human))		BDBM50476173
PNG
(CHEMBL222973)
Show SMILES CC(Oc1ccccc1-c1cccc(C)c1)C1=NCCN1 |t:18|
Show InChI InChI=1S/C18H20N2O/c1-13-6-5-7-15(12-13)16-8-3-4-9-17(16)21-14(2)18-19-10-11-20-18/h3-9,12,14H,10-11H2,1-2H3,(H,19,20)
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 245n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Camerino

Curated by ChEMBL


Assay Description
Displacement of [3H]RX821002 from human adrenergic Alpha-2C receptor expressed in CHO cells

J Med Chem 47: 6160-73 (2004)


Article DOI: 10.1021/jm0408215
BindingDB Entry DOI: 10.7270/Q2B27Z13
More data for this
Ligand-Target Pair
Alpha-2C adrenergic receptor


(Homo sapiens (Human))		BDBM50476175
PNG
(CHEMBL426900)
Show SMILES CC(Oc1ccccc1-c1ccc(C)cc1)C1=NCCN1 |t:18|
Show InChI InChI=1S/C18H20N2O/c1-13-7-9-15(10-8-13)16-5-3-4-6-17(16)21-14(2)18-19-11-12-20-18/h3-10,14H,11-12H2,1-2H3,(H,19,20)
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 251n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Camerino

Curated by ChEMBL


Assay Description
Displacement of [3H]RX821002 from human adrenergic Alpha-2C receptor expressed in CHO cells

J Med Chem 47: 6160-73 (2004)


Article DOI: 10.1021/jm0408215
BindingDB Entry DOI: 10.7270/Q2B27Z13
More data for this
Ligand-Target Pair
Alpha-2B adrenergic receptor


(Homo sapiens (Human))		BDBM50002903
PNG
(CHEMBL223836)
Show SMILES CC(Oc1ccccc1-c1cccc(F)c1)C1=NCCN1 |t:18|
Show InChI InChI=1S/C17H17FN2O/c1-12(17-19-9-10-20-17)21-16-8-3-2-7-15(16)13-5-4-6-14(18)11-13/h2-8,11-12H,9-10H2,1H3,(H,19,20)
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 269n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Camerino

Curated by ChEMBL


Assay Description
Displacement of [3H]RX821002 from human adrenergic alpha-2B receptor expressed in CHO cells

J Med Chem 47: 6160-73 (2004)


Article DOI: 10.1021/jm0408215
BindingDB Entry DOI: 10.7270/Q2B27Z13
More data for this
Ligand-Target Pair
Alpha-2A adrenergic receptor


(Homo sapiens (Human))		BDBM50476181
PNG
(CHEMBL442045)
Show SMILES CC(Oc1ccccc1-c1ccncc1)C1=NCCN1 |t:17|
Show InChI InChI=1S/C16H17N3O/c1-12(16-18-10-11-19-16)20-15-5-3-2-4-14(15)13-6-8-17-9-7-13/h2-9,12H,10-11H2,1H3,(H,18,19)
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 282n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Camerino

Curated by ChEMBL


Assay Description
Displacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cells

J Med Chem 47: 6160-73 (2004)


Article DOI: 10.1021/jm0408215
BindingDB Entry DOI: 10.7270/Q2B27Z13
More data for this
Ligand-Target Pair
Alpha-2C adrenergic receptor


(Homo sapiens (Human))		BDBM50476187
PNG
(CHEMBL221523)
Show SMILES CC(Oc1ccccc1-c1ccc(cc1)[N+]([O-])=O)C1=NCCN1 |t:20|
Show InChI InChI=1S/C17H17N3O3/c1-12(17-18-10-11-19-17)23-16-5-3-2-4-15(16)13-6-8-14(9-7-13)20(21)22/h2-9,12H,10-11H2,1H3,(H,18,19)
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 302n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Camerino

Curated by ChEMBL


Assay Description
Displacement of [3H]RX821002 from human adrenergic Alpha-2C receptor expressed in CHO cells

J Med Chem 47: 6160-73 (2004)


Article DOI: 10.1021/jm0408215
BindingDB Entry DOI: 10.7270/Q2B27Z13
More data for this
Ligand-Target Pair
Alpha-2A adrenergic receptor


(Homo sapiens (Human))		BDBM50476180
PNG
(CHEMBL373830)
Show SMILES CC(Oc1ccccc1-c1ccccc1O)C1=NCCN1 |t:18|
Show InChI InChI=1S/C17H18N2O2/c1-12(17-18-10-11-19-17)21-16-9-5-3-7-14(16)13-6-2-4-8-15(13)20/h2-9,12,20H,10-11H2,1H3,(H,18,19)
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 309n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Camerino

Curated by ChEMBL


Assay Description
Displacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cells

J Med Chem 47: 6160-73 (2004)


Article DOI: 10.1021/jm0408215
BindingDB Entry DOI: 10.7270/Q2B27Z13
More data for this
Ligand-Target Pair
Alpha-2C adrenergic receptor


(Homo sapiens (Human))		BDBM50476185
PNG
(CHEMBL222371)
Show SMILES CC(Oc1ccccc1-c1cccc(N)c1)C1=NCCN1 |t:18|
Show InChI InChI=1S/C17H19N3O/c1-12(17-19-9-10-20-17)21-16-8-3-2-7-15(16)13-5-4-6-14(18)11-13/h2-8,11-12H,9-10,18H2,1H3,(H,19,20)
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 309n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Camerino

Curated by ChEMBL


Assay Description
Displacement of [3H]RX821002 from human adrenergic Alpha-2C receptor expressed in CHO cells

J Med Chem 47: 6160-73 (2004)


Article DOI: 10.1021/jm0408215
BindingDB Entry DOI: 10.7270/Q2B27Z13
More data for this
Ligand-Target Pair
Alpha-2C adrenergic receptor


(Homo sapiens (Human))		BDBM50476174
PNG
(CHEMBL222798)
Show SMILES CC(Oc1ccccc1-c1ccc(O)cc1)C1=NCCN1 |t:18|
Show InChI InChI=1S/C17H18N2O2/c1-12(17-18-10-11-19-17)21-16-5-3-2-4-15(16)13-6-8-14(20)9-7-13/h2-9,12,20H,10-11H2,1H3,(H,18,19)
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 331n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Camerino

Curated by ChEMBL


Assay Description
Displacement of [3H]RX821002 from human adrenergic Alpha-2C receptor expressed in CHO cells

J Med Chem 47: 6160-73 (2004)


Article DOI: 10.1021/jm0408215
BindingDB Entry DOI: 10.7270/Q2B27Z13
More data for this
Ligand-Target Pair
Alpha-2A adrenergic receptor


(Homo sapiens (Human))		BDBM50476182
PNG
(CHEMBL374954)
Show SMILES CC(Sc1ccccc1-c1ccccc1)C1=NCCN1 |t:17|
Show InChI InChI=1S/C17H18N2S/c1-13(17-18-11-12-19-17)20-16-10-6-5-9-15(16)14-7-3-2-4-8-14/h2-10,13H,11-12H2,1H3,(H,18,19)
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 339n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Camerino

Curated by ChEMBL


Assay Description
Displacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cells

J Med Chem 47: 6160-73 (2004)


Article DOI: 10.1021/jm0408215
BindingDB Entry DOI: 10.7270/Q2B27Z13
More data for this
Ligand-Target Pair
Alpha-2B adrenergic receptor


(Homo sapiens (Human))		BDBM50417350
PNG
(CHEMBL374584)
Show SMILES CC(Oc1ccccc1-c1cccc(O)c1)C1=NCCN1 |t:18|
Show InChI InChI=1S/C17H18N2O2/c1-12(17-18-9-10-19-17)21-16-8-3-2-7-15(16)13-5-4-6-14(20)11-13/h2-8,11-12,20H,9-10H2,1H3,(H,18,19)
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 355n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Camerino

Curated by ChEMBL


Assay Description
Displacement of [3H]RX821002 from human adrenergic alpha-2B receptor expressed in CHO cells

J Med Chem 47: 6160-73 (2004)


Article DOI: 10.1021/jm0408215
BindingDB Entry DOI: 10.7270/Q2B27Z13
More data for this
Ligand-Target Pair
Alpha-2B adrenergic receptor


(Homo sapiens (Human))		BDBM50476175
PNG
(CHEMBL426900)
Show SMILES CC(Oc1ccccc1-c1ccc(C)cc1)C1=NCCN1 |t:18|
Show InChI InChI=1S/C18H20N2O/c1-13-7-9-15(10-8-13)16-5-3-4-6-17(16)21-14(2)18-19-11-12-20-18/h3-10,14H,11-12H2,1-2H3,(H,19,20)
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 398n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Camerino

Curated by ChEMBL


Assay Description
Displacement of [3H]RX821002 from human adrenergic alpha-2B receptor expressed in CHO cells

J Med Chem 47: 6160-73 (2004)


Article DOI: 10.1021/jm0408215
BindingDB Entry DOI: 10.7270/Q2B27Z13
More data for this
Ligand-Target Pair
Alpha-2B adrenergic receptor


(Homo sapiens (Human))		BDBM50417347
PNG
(CHEMBL385310)
Show SMILES CC(Oc1ccccc1-c1ccsc1)C1=NCCN1 |t:16|
Show InChI InChI=1S/C15H16N2OS/c1-11(15-16-7-8-17-15)18-14-5-3-2-4-13(14)12-6-9-19-10-12/h2-6,9-11H,7-8H2,1H3,(H,16,17)
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 417n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Camerino

Curated by ChEMBL


Assay Description
Displacement of [3H]RX821002 from human adrenergic alpha-2B receptor expressed in CHO cells

J Med Chem 47: 6160-73 (2004)


Article DOI: 10.1021/jm0408215
BindingDB Entry DOI: 10.7270/Q2B27Z13
More data for this
Ligand-Target Pair
Alpha-2B adrenergic receptor


(Homo sapiens (Human))		BDBM50476185
PNG
(CHEMBL222371)
Show SMILES CC(Oc1ccccc1-c1cccc(N)c1)C1=NCCN1 |t:18|
Show InChI InChI=1S/C17H19N3O/c1-12(17-19-9-10-20-17)21-16-8-3-2-7-15(16)13-5-4-6-14(18)11-13/h2-8,11-12H,9-10,18H2,1H3,(H,19,20)
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 479n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Camerino

Curated by ChEMBL


Assay Description
Displacement of [3H]RX821002 from human adrenergic alpha-2B receptor expressed in CHO cells

J Med Chem 47: 6160-73 (2004)


Article DOI: 10.1021/jm0408215
BindingDB Entry DOI: 10.7270/Q2B27Z13
More data for this
Ligand-Target Pair
Alpha-2B adrenergic receptor


(Homo sapiens (Human))		BDBM50476187
PNG
(CHEMBL221523)
Show SMILES CC(Oc1ccccc1-c1ccc(cc1)[N+]([O-])=O)C1=NCCN1 |t:20|
Show InChI InChI=1S/C17H17N3O3/c1-12(17-18-10-11-19-17)23-16-5-3-2-4-15(16)13-6-8-14(9-7-13)20(21)22/h2-9,12H,10-11H2,1H3,(H,18,19)
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 501n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Camerino

Curated by ChEMBL


Assay Description
Displacement of [3H]RX821002 from human adrenergic alpha-2B receptor expressed in CHO cells

J Med Chem 47: 6160-73 (2004)


Article DOI: 10.1021/jm0408215
BindingDB Entry DOI: 10.7270/Q2B27Z13
More data for this
Ligand-Target Pair
Alpha-2B adrenergic receptor


(Homo sapiens (Human))		BDBM50412250
PNG
(CHEMBL128168)
Show SMILES CC(Oc1ccccc1-c1ccccc1)C1=NCCN1 |t:17|
Show InChI InChI=1S/C17H18N2O/c1-13(17-18-11-12-19-17)20-16-10-6-5-9-15(16)14-7-3-2-4-8-14/h2-10,13H,11-12H2,1H3,(H,18,19)
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 501n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Camerino

Curated by ChEMBL


Assay Description
Displacement of [3H]RX821002 from human adrenergic alpha-2B receptor expressed in CHO cells

J Med Chem 47: 6160-73 (2004)


Article DOI: 10.1021/jm0408215
BindingDB Entry DOI: 10.7270/Q2B27Z13
More data for this
Ligand-Target Pair
Alpha-2B adrenergic receptor


(Homo sapiens (Human))		BDBM50476173
PNG
(CHEMBL222973)
Show SMILES CC(Oc1ccccc1-c1cccc(C)c1)C1=NCCN1 |t:18|
Show InChI InChI=1S/C18H20N2O/c1-13-6-5-7-15(12-13)16-8-3-4-9-17(16)21-14(2)18-19-10-11-20-18/h3-9,12,14H,10-11H2,1-2H3,(H,19,20)
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 537n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Camerino

Curated by ChEMBL


Assay Description
Displacement of [3H]RX821002 from human adrenergic alpha-2B receptor expressed in CHO cells

J Med Chem 47: 6160-73 (2004)


Article DOI: 10.1021/jm0408215
BindingDB Entry DOI: 10.7270/Q2B27Z13
More data for this
Ligand-Target Pair
Alpha-2B adrenergic receptor


(Homo sapiens (Human))		BDBM50002904
PNG
(CHEMBL222928)
Show SMILES CC(Oc1ccccc1-c1cccc(c1)[N+]([O-])=O)C1=NCCN1 |t:20|
Show InChI InChI=1S/C17H17N3O3/c1-12(17-18-9-10-19-17)23-16-8-3-2-7-15(16)13-5-4-6-14(11-13)20(21)22/h2-8,11-12H,9-10H2,1H3,(H,18,19)
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 661n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Camerino

Curated by ChEMBL


Assay Description
Displacement of [3H]RX821002 from human adrenergic alpha-2B receptor expressed in CHO cells

J Med Chem 47: 6160-73 (2004)


Article DOI: 10.1021/jm0408215
BindingDB Entry DOI: 10.7270/Q2B27Z13
More data for this
Ligand-Target Pair
Alpha-2C adrenergic receptor


(Homo sapiens (Human))		BDBM50473619
PNG
(CHEMBL130884)
Show SMILES CC(Nc1ccccc1-c1ccccc1)C1=NCCN1 |t:17|
Show InChI InChI=1S/C17H19N3/c1-13(17-18-11-12-19-17)20-16-10-6-5-9-15(16)14-7-3-2-4-8-14/h2-10,13,20H,11-12H2,1H3,(H,18,19)
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 708n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Camerino

Curated by ChEMBL


Assay Description
Displacement of [3H]RX821002 from human adrenergic Alpha-2C receptor expressed in CHO cells

J Med Chem 47: 6160-73 (2004)


Article DOI: 10.1021/jm0408215
BindingDB Entry DOI: 10.7270/Q2B27Z13
More data for this
Ligand-Target Pair
Alpha-2C adrenergic receptor


(Homo sapiens (Human))		BDBM50476182
PNG
(CHEMBL374954)
Show SMILES CC(Sc1ccccc1-c1ccccc1)C1=NCCN1 |t:17|
Show InChI InChI=1S/C17H18N2S/c1-13(17-18-11-12-19-17)20-16-10-6-5-9-15(16)14-7-3-2-4-8-14/h2-10,13H,11-12H2,1H3,(H,18,19)
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 708n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Camerino

Curated by ChEMBL


Assay Description
Displacement of [3H]RX821002 from human adrenergic Alpha-2C receptor expressed in CHO cells

J Med Chem 47: 6160-73 (2004)


Article DOI: 10.1021/jm0408215
BindingDB Entry DOI: 10.7270/Q2B27Z13
More data for this
Ligand-Target Pair
Alpha-2B adrenergic receptor


(Homo sapiens (Human))		BDBM50476174
PNG
(CHEMBL222798)
Show SMILES CC(Oc1ccccc1-c1ccc(O)cc1)C1=NCCN1 |t:18|
Show InChI InChI=1S/C17H18N2O2/c1-12(17-18-10-11-19-17)21-16-5-3-2-4-15(16)13-6-8-14(20)9-7-13/h2-9,12,20H,10-11H2,1H3,(H,18,19)
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 813n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Camerino

Curated by ChEMBL


Assay Description
Displacement of [3H]RX821002 from human adrenergic alpha-2B receptor expressed in CHO cells

J Med Chem 47: 6160-73 (2004)


Article DOI: 10.1021/jm0408215
BindingDB Entry DOI: 10.7270/Q2B27Z13
More data for this
Ligand-Target Pair
Alpha-2B adrenergic receptor


(Homo sapiens (Human))		BDBM50476188
PNG
(CHEMBL223830)
Show SMILES CC(Oc1ccccc1-c1ccccc1C)C1=NCCN1 |t:18|
Show InChI InChI=1S/C18H20N2O/c1-13-7-3-4-8-15(13)16-9-5-6-10-17(16)21-14(2)18-19-11-12-20-18/h3-10,14H,11-12H2,1-2H3,(H,19,20)
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 832n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Camerino

Curated by ChEMBL


Assay Description
Displacement of [3H]RX821002 from human adrenergic alpha-2B receptor expressed in CHO cells

J Med Chem 47: 6160-73 (2004)


Article DOI: 10.1021/jm0408215
BindingDB Entry DOI: 10.7270/Q2B27Z13
More data for this
Ligand-Target Pair
Alpha-2B adrenergic receptor


(Homo sapiens (Human))		BDBM50002905
PNG
(CHEMBL373535)
Show SMILES CC(Oc1ccccc1-c1cccnc1)C1=NCCN1 |t:17|
Show InChI InChI=1S/C16H17N3O/c1-12(16-18-9-10-19-16)20-15-7-3-2-6-14(15)13-5-4-8-17-11-13/h2-8,11-12H,9-10H2,1H3,(H,18,19)
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 933n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Camerino

Curated by ChEMBL


Assay Description
Displacement of [3H]RX821002 from human adrenergic alpha-2B receptor expressed in CHO cells

J Med Chem 47: 6160-73 (2004)


Article DOI: 10.1021/jm0408215
BindingDB Entry DOI: 10.7270/Q2B27Z13
More data for this
Ligand-Target Pair
Alpha-2B adrenergic receptor


(Homo sapiens (Human))		BDBM50476180
PNG
(CHEMBL373830)
Show SMILES CC(Oc1ccccc1-c1ccccc1O)C1=NCCN1 |t:18|
Show InChI InChI=1S/C17H18N2O2/c1-12(17-18-10-11-19-17)21-16-9-5-3-7-14(16)13-6-2-4-8-15(13)20/h2-9,12,20H,10-11H2,1H3,(H,18,19)
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 1.00E+3n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Camerino

Curated by ChEMBL


Assay Description
Displacement of [3H]RX821002 from human adrenergic alpha-2B receptor expressed in CHO cells

J Med Chem 47: 6160-73 (2004)


Article DOI: 10.1021/jm0408215
BindingDB Entry DOI: 10.7270/Q2B27Z13
More data for this
Ligand-Target Pair
Alpha-2B adrenergic receptor


(Homo sapiens (Human))		BDBM50473619
PNG
(CHEMBL130884)
Show SMILES CC(Nc1ccccc1-c1ccccc1)C1=NCCN1 |t:17|
Show InChI InChI=1S/C17H19N3/c1-13(17-18-11-12-19-17)20-16-10-6-5-9-15(16)14-7-3-2-4-8-14/h2-10,13,20H,11-12H2,1H3,(H,18,19)
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 1.15E+3n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Camerino

Curated by ChEMBL


Assay Description
Displacement of [3H]RX821002 from human adrenergic alpha-2B receptor expressed in CHO cells

J Med Chem 47: 6160-73 (2004)


Article DOI: 10.1021/jm0408215
BindingDB Entry DOI: 10.7270/Q2B27Z13
More data for this
Ligand-Target Pair
Alpha-2A adrenergic receptor


(Homo sapiens (Human))		BDBM50476179
PNG
(CHEMBL221989)
Show SMILES CC(Oc1ccccc1-c1ccccn1)C1=NCCN1 |t:17|
Show InChI InChI=1S/C16H17N3O/c1-12(16-18-10-11-19-16)20-15-8-3-2-6-13(15)14-7-4-5-9-17-14/h2-9,12H,10-11H2,1H3,(H,18,19)
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 1.20E+3n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Camerino

Curated by ChEMBL


Assay Description
Displacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cells

J Med Chem 47: 6160-73 (2004)


Article DOI: 10.1021/jm0408215
BindingDB Entry DOI: 10.7270/Q2B27Z13
More data for this
Ligand-Target Pair
Alpha-2C adrenergic receptor


(Homo sapiens (Human))		BDBM50476177
PNG
(CHEMBL222138)
Show SMILES CC(Oc1ccccc1-c1ccccc1[N+]([O-])=O)C1=NCCN1 |t:20|
Show InChI InChI=1S/C17H17N3O3/c1-12(17-18-10-11-19-17)23-16-9-5-3-7-14(16)13-6-2-4-8-15(13)20(21)22/h2-9,12H,10-11H2,1H3,(H,18,19)
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 1.23E+3n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Camerino

Curated by ChEMBL


Assay Description
Displacement of [3H]RX821002 from human adrenergic Alpha-2C receptor expressed in CHO cells

J Med Chem 47: 6160-73 (2004)


Article DOI: 10.1021/jm0408215
BindingDB Entry DOI: 10.7270/Q2B27Z13
More data for this
Ligand-Target Pair
Alpha-2B adrenergic receptor


(Homo sapiens (Human))		BDBM50476183
PNG
(CHEMBL1204386)
Show SMILES Cl.C1CN=C(N1)C1OC1c1ccccc1-c1ccccc1 |c:2|
Show InChI InChI=1S/C17H16N2O.ClH/c1-2-6-12(7-3-1)13-8-4-5-9-14(13)15-16(20-15)17-18-10-11-19-17;/h1-9,15-16H,10-11H2,(H,18,19);1H
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 1.23E+3n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Camerino

Curated by ChEMBL


Assay Description
Displacement of [3H]RX821002 from human adrenergic alpha-2B receptor expressed in CHO cells

J Med Chem 47: 6160-73 (2004)


Article DOI: 10.1021/jm0408215
BindingDB Entry DOI: 10.7270/Q2B27Z13
More data for this
Ligand-Target Pair
Alpha-2A adrenergic receptor


(Homo sapiens (Human))		BDBM50476186
PNG
(CHEMBL222933)
Show SMILES C1CN=C(N1)C1OC1c1ccccc1-c1ccccc1 |c:2|
Show InChI InChI=1S/C17H16N2O/c1-2-6-12(7-3-1)13-8-4-5-9-14(13)15-16(20-15)17-18-10-11-19-17/h1-9,15-16H,10-11H2,(H,18,19)
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 1.23E+3n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Camerino

Curated by ChEMBL


Assay Description
Displacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cells

J Med Chem 47: 6160-73 (2004)


Article DOI: 10.1021/jm0408215
BindingDB Entry DOI: 10.7270/Q2B27Z13
More data for this
Ligand-Target Pair
Alpha-2C adrenergic receptor


(Homo sapiens (Human))		BDBM50476179
PNG
(CHEMBL221989)
Show SMILES CC(Oc1ccccc1-c1ccccn1)C1=NCCN1 |t:17|
Show InChI InChI=1S/C16H17N3O/c1-12(16-18-10-11-19-16)20-15-8-3-2-6-13(15)14-7-4-5-9-17-14/h2-9,12H,10-11H2,1H3,(H,18,19)
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 1.26E+3n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Camerino

Curated by ChEMBL


Assay Description
Displacement of [3H]RX821002 from human adrenergic Alpha-2C receptor expressed in CHO cells

J Med Chem 47: 6160-73 (2004)


Article DOI: 10.1021/jm0408215
BindingDB Entry DOI: 10.7270/Q2B27Z13
More data for this
Ligand-Target Pair
Alpha-2C adrenergic receptor


(Homo sapiens (Human))		BDBM50476181
PNG
(CHEMBL442045)
Show SMILES CC(Oc1ccccc1-c1ccncc1)C1=NCCN1 |t:17|
Show InChI InChI=1S/C16H17N3O/c1-12(16-18-10-11-19-16)20-15-5-3-2-4-14(15)13-6-8-17-9-7-13/h2-9,12H,10-11H2,1H3,(H,18,19)
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 1.45E+3n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Camerino

Curated by ChEMBL


Assay Description
Displacement of [3H]RX821002 from human adrenergic Alpha-2C receptor expressed in CHO cells

J Med Chem 47: 6160-73 (2004)


Article DOI: 10.1021/jm0408215
BindingDB Entry DOI: 10.7270/Q2B27Z13
More data for this
Ligand-Target Pair
Alpha-2A adrenergic receptor


(Homo sapiens (Human))		BDBM50476183
PNG
(CHEMBL1204386)
Show SMILES Cl.C1CN=C(N1)C1OC1c1ccccc1-c1ccccc1 |c:2|
Show InChI InChI=1S/C17H16N2O.ClH/c1-2-6-12(7-3-1)13-8-4-5-9-14(13)15-16(20-15)17-18-10-11-19-17;/h1-9,15-16H,10-11H2,(H,18,19);1H
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 1.51E+3n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Camerino

Curated by ChEMBL


Assay Description
Displacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cells

J Med Chem 47: 6160-73 (2004)


Article DOI: 10.1021/jm0408215
BindingDB Entry DOI: 10.7270/Q2B27Z13
More data for this
Ligand-Target Pair
Alpha-2B adrenergic receptor


(Homo sapiens (Human))		BDBM50476177
PNG
(CHEMBL222138)
Show SMILES CC(Oc1ccccc1-c1ccccc1[N+]([O-])=O)C1=NCCN1 |t:20|
Show InChI InChI=1S/C17H17N3O3/c1-12(17-18-10-11-19-17)23-16-9-5-3-7-14(16)13-6-2-4-8-15(13)20(21)22/h2-9,12H,10-11H2,1H3,(H,18,19)
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 1.55E+3n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Camerino

Curated by ChEMBL


Assay Description
Displacement of [3H]RX821002 from human adrenergic alpha-2B receptor expressed in CHO cells

J Med Chem 47: 6160-73 (2004)


Article DOI: 10.1021/jm0408215
BindingDB Entry DOI: 10.7270/Q2B27Z13
More data for this
Ligand-Target Pair
Alpha-2C adrenergic receptor


(Homo sapiens (Human))		BDBM50476180
PNG
(CHEMBL373830)
Show SMILES CC(Oc1ccccc1-c1ccccc1O)C1=NCCN1 |t:18|
Show InChI InChI=1S/C17H18N2O2/c1-12(17-18-10-11-19-17)21-16-9-5-3-7-14(16)13-6-2-4-8-15(13)20/h2-9,12,20H,10-11H2,1H3,(H,18,19)
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 1.62E+3n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Camerino

Curated by ChEMBL


Assay Description
Displacement of [3H]RX821002 from human adrenergic Alpha-2C receptor expressed in CHO cells

J Med Chem 47: 6160-73 (2004)


Article DOI: 10.1021/jm0408215
BindingDB Entry DOI: 10.7270/Q2B27Z13
More data for this
Ligand-Target Pair
Amine oxidase [flavin-containing] A/B


(Homo sapiens (Human))		BDBM50412250
PNG
(CHEMBL128168)
Show SMILES CC(Oc1ccccc1-c1ccccc1)C1=NCCN1 |t:17|
Show InChI InChI=1S/C17H18N2O/c1-13(17-18-11-12-19-17)20-16-10-6-5-9-15(16)14-7-3-2-4-8-14/h2-10,13H,11-12H2,1H3,(H,18,19)
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 1.62E+3n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Camerino

Curated by ChEMBL


Assay Description
Binding affinity to imidazoline receptor 2

J Med Chem 47: 6160-73 (2004)


Article DOI: 10.1021/jm0408215
BindingDB Entry DOI: 10.7270/Q2B27Z13
More data for this
Ligand-Target Pair
Alpha-2B adrenergic receptor


(Homo sapiens (Human))		BDBM50476181
PNG
(CHEMBL442045)
Show SMILES CC(Oc1ccccc1-c1ccncc1)C1=NCCN1 |t:17|
Show InChI InChI=1S/C16H17N3O/c1-12(16-18-10-11-19-16)20-15-5-3-2-4-14(15)13-6-8-17-9-7-13/h2-9,12H,10-11H2,1H3,(H,18,19)
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 2.69E+3n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Camerino

Curated by ChEMBL


Assay Description
Displacement of [3H]RX821002 from human adrenergic alpha-2B receptor expressed in CHO cells

J Med Chem 47: 6160-73 (2004)


Article DOI: 10.1021/jm0408215
BindingDB Entry DOI: 10.7270/Q2B27Z13
More data for this
Ligand-Target Pair
Alpha-2B adrenergic receptor


(Homo sapiens (Human))		BDBM50476179
PNG
(CHEMBL221989)
Show SMILES CC(Oc1ccccc1-c1ccccn1)C1=NCCN1 |t:17|
Show InChI InChI=1S/C16H17N3O/c1-12(16-18-10-11-19-16)20-15-8-3-2-6-13(15)14-7-4-5-9-17-14/h2-9,12H,10-11H2,1H3,(H,18,19)
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 3.31E+3n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Camerino

Curated by ChEMBL


Assay Description
Displacement of [3H]RX821002 from human adrenergic alpha-2B receptor expressed in CHO cells

J Med Chem 47: 6160-73 (2004)


Article DOI: 10.1021/jm0408215
BindingDB Entry DOI: 10.7270/Q2B27Z13
More data for this
Ligand-Target Pair
Alpha-2B adrenergic receptor


(Homo sapiens (Human))		BDBM50476182
PNG
(CHEMBL374954)
Show SMILES CC(Sc1ccccc1-c1ccccc1)C1=NCCN1 |t:17|
Show InChI InChI=1S/C17H18N2S/c1-13(17-18-11-12-19-17)20-16-10-6-5-9-15(16)14-7-3-2-4-8-14/h2-10,13H,11-12H2,1H3,(H,18,19)
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 3.55E+3n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Camerino

Curated by ChEMBL


Assay Description
Displacement of [3H]RX821002 from human adrenergic alpha-2B receptor expressed in CHO cells

J Med Chem 47: 6160-73 (2004)


Article DOI: 10.1021/jm0408215
BindingDB Entry DOI: 10.7270/Q2B27Z13
More data for this
Ligand-Target Pair
Alpha-2C adrenergic receptor


(Homo sapiens (Human))		BDBM50476183
PNG
(CHEMBL1204386)
Show SMILES Cl.C1CN=C(N1)C1OC1c1ccccc1-c1ccccc1 |c:2|
Show InChI InChI=1S/C17H16N2O.ClH/c1-2-6-12(7-3-1)13-8-4-5-9-14(13)15-16(20-15)17-18-10-11-19-17;/h1-9,15-16H,10-11H2,(H,18,19);1H
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 4.27E+3n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Camerino

Curated by ChEMBL


Assay Description
Displacement of [3H]RX821002 from human adrenergic Alpha-2C receptor expressed in CHO cells

J Med Chem 47: 6160-73 (2004)


Article DOI: 10.1021/jm0408215
BindingDB Entry DOI: 10.7270/Q2B27Z13
More data for this
Ligand-Target Pair
Alpha-2C adrenergic receptor


(Homo sapiens (Human))		BDBM50476184
PNG
(CHEMBL222593)
Show SMILES CC(Oc1ccccc1-c1ccccc1)C1=NCCC1 |t:17|
Show InChI InChI=1S/C18H19NO/c1-14(17-11-7-13-19-17)20-18-12-6-5-10-16(18)15-8-3-2-4-9-15/h2-6,8-10,12,14H,7,11,13H2,1H3
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 5.89E+3n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Camerino

Curated by ChEMBL


Assay Description
Displacement of [3H]RX821002 from human adrenergic Alpha-2C receptor expressed in CHO cells

J Med Chem 47: 6160-73 (2004)


Article DOI: 10.1021/jm0408215
BindingDB Entry DOI: 10.7270/Q2B27Z13
More data for this
Ligand-Target Pair
Alpha-2C adrenergic receptor


(Homo sapiens (Human))		BDBM50476172
PNG
(CHEMBL222591)
Show SMILES CC(Oc1ccccc1-c1ccccc1)C1=NCCO1 |t:17|
Show InChI InChI=1S/C17H17NO2/c1-13(17-18-11-12-19-17)20-16-10-6-5-9-15(16)14-7-3-2-4-8-14/h2-10,13H,11-12H2,1H3
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 5.89E+3n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Camerino

Curated by ChEMBL


Assay Description
Displacement of [3H]RX821002 from human adrenergic Alpha-2C receptor expressed in CHO cells

J Med Chem 47: 6160-73 (2004)


Article DOI: 10.1021/jm0408215
BindingDB Entry DOI: 10.7270/Q2B27Z13
More data for this
Ligand-Target Pair
Alpha-2C adrenergic receptor


(Homo sapiens (Human))		BDBM50476186
PNG
(CHEMBL222933)
Show SMILES C1CN=C(N1)C1OC1c1ccccc1-c1ccccc1 |c:2|
Show InChI InChI=1S/C17H16N2O/c1-2-6-12(7-3-1)13-8-4-5-9-14(13)15-16(20-15)17-18-10-11-19-17/h1-9,15-16H,10-11H2,(H,18,19)
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 6.46E+3n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Camerino

Curated by ChEMBL


Assay Description
Displacement of [3H]RX821002 from human adrenergic Alpha-2C receptor expressed in CHO cells

J Med Chem 47: 6160-73 (2004)


Article DOI: 10.1021/jm0408215
BindingDB Entry DOI: 10.7270/Q2B27Z13
More data for this
Ligand-Target Pair
Alpha-2A adrenergic receptor


(Homo sapiens (Human))		BDBM50476184
PNG
(CHEMBL222593)
Show SMILES CC(Oc1ccccc1-c1ccccc1)C1=NCCC1 |t:17|
Show InChI InChI=1S/C18H19NO/c1-14(17-11-7-13-19-17)20-18-12-6-5-10-16(18)15-8-3-2-4-9-15/h2-6,8-10,12,14H,7,11,13H2,1H3
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 8.13E+3n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Camerino

Curated by ChEMBL


Assay Description
Displacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cells

J Med Chem 47: 6160-73 (2004)


Article DOI: 10.1021/jm0408215
BindingDB Entry DOI: 10.7270/Q2B27Z13
More data for this
Ligand-Target Pair
Alpha-2A adrenergic receptor


(Homo sapiens (Human))		BDBM50476172
PNG
(CHEMBL222591)
Show SMILES CC(Oc1ccccc1-c1ccccc1)C1=NCCO1 |t:17|
Show InChI InChI=1S/C17H17NO2/c1-13(17-18-11-12-19-17)20-16-10-6-5-9-15(16)14-7-3-2-4-8-14/h2-10,13H,11-12H2,1H3
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 8.13E+3n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Camerino

Curated by ChEMBL


Assay Description
Displacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cells

J Med Chem 47: 6160-73 (2004)


Article DOI: 10.1021/jm0408215
BindingDB Entry DOI: 10.7270/Q2B27Z13
More data for this
Ligand-Target Pair
Alpha-2A adrenergic receptor


(Homo sapiens (Human))		BDBM50476176
PNG
(CHEMBL222592)
Show SMILES CC(Oc1ccccc1-c1ccccc1)C1=NCCS1 |t:17|
Show InChI InChI=1S/C17H17NOS/c1-13(17-18-11-12-20-17)19-16-10-6-5-9-15(16)14-7-3-2-4-8-14/h2-10,13H,11-12H2,1H3
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<1.00E+4n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Camerino

Curated by ChEMBL


Assay Description
Displacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cells

J Med Chem 47: 6160-73 (2004)


Article DOI: 10.1021/jm0408215
BindingDB Entry DOI: 10.7270/Q2B27Z13
More data for this
Ligand-Target Pair
Alpha-2B adrenergic receptor


(Homo sapiens (Human))		BDBM50476184
PNG
(CHEMBL222593)
Show SMILES CC(Oc1ccccc1-c1ccccc1)C1=NCCC1 |t:17|
Show InChI InChI=1S/C18H19NO/c1-14(17-11-7-13-19-17)20-18-12-6-5-10-16(18)15-8-3-2-4-9-15/h2-6,8-10,12,14H,7,11,13H2,1H3
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 1.00E+4n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Camerino

Curated by ChEMBL


Assay Description
Displacement of [3H]RX821002 from human adrenergic alpha-2B receptor expressed in CHO cells

J Med Chem 47: 6160-73 (2004)


Article DOI: 10.1021/jm0408215
BindingDB Entry DOI: 10.7270/Q2B27Z13
More data for this
Ligand-Target Pair
Alpha-2B adrenergic receptor


(Homo sapiens (Human))		BDBM50476176
PNG
(CHEMBL222592)
Show SMILES CC(Oc1ccccc1-c1ccccc1)C1=NCCS1 |t:17|
Show InChI InChI=1S/C17H17NOS/c1-13(17-18-11-12-20-17)19-16-10-6-5-9-15(16)14-7-3-2-4-8-14/h2-10,13H,11-12H2,1H3
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<1.00E+4n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Camerino

Curated by ChEMBL


Assay Description
Displacement of [3H]RX821002 from human adrenergic alpha-2B receptor expressed in CHO cells

J Med Chem 47: 6160-73 (2004)


Article DOI: 10.1021/jm0408215
BindingDB Entry DOI: 10.7270/Q2B27Z13
More data for this
Ligand-Target Pair
Alpha-2C adrenergic receptor


(Homo sapiens (Human))		BDBM50476176
PNG
(CHEMBL222592)
Show SMILES CC(Oc1ccccc1-c1ccccc1)C1=NCCS1 |t:17|
Show InChI InChI=1S/C17H17NOS/c1-13(17-18-11-12-20-17)19-16-10-6-5-9-15(16)14-7-3-2-4-8-14/h2-10,13H,11-12H2,1H3
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<1.00E+4n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Camerino

Curated by ChEMBL


Assay Description
Displacement of [3H]RX821002 from human adrenergic Alpha-2C receptor expressed in CHO cells

J Med Chem 47: 6160-73 (2004)


Article DOI: 10.1021/jm0408215
BindingDB Entry DOI: 10.7270/Q2B27Z13
More data for this
Ligand-Target Pair
Alpha-2B adrenergic receptor


(Homo sapiens (Human))		BDBM50476172
PNG
(CHEMBL222591)
Show SMILES CC(Oc1ccccc1-c1ccccc1)C1=NCCO1 |t:17|
Show InChI InChI=1S/C17H17NO2/c1-13(17-18-11-12-19-17)20-16-10-6-5-9-15(16)14-7-3-2-4-8-14/h2-10,13H,11-12H2,1H3
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 1.00E+4n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Camerino

Curated by ChEMBL


Assay Description
Displacement of [3H]RX821002 from human adrenergic alpha-2B receptor expressed in CHO cells

J Med Chem 47: 6160-73 (2004)


Article DOI: 10.1021/jm0408215
BindingDB Entry DOI: 10.7270/Q2B27Z13
More data for this
Ligand-Target Pair
Alpha-2B adrenergic receptor


(Homo sapiens (Human))		BDBM50476186
PNG
(CHEMBL222933)
Show SMILES C1CN=C(N1)C1OC1c1ccccc1-c1ccccc1 |c:2|
Show InChI InChI=1S/C17H16N2O/c1-2-6-12(7-3-1)13-8-4-5-9-14(13)15-16(20-15)17-18-10-11-19-17/h1-9,15-16H,10-11H2,(H,18,19)
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 2.00E+4n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Camerino

Curated by ChEMBL


Assay Description
Displacement of [3H]RX821002 from human adrenergic alpha-2B receptor expressed in CHO cells

J Med Chem 47: 6160-73 (2004)


Article DOI: 10.1021/jm0408215
BindingDB Entry DOI: 10.7270/Q2B27Z13
More data for this
Ligand-Target Pair
Alpha-2C adrenergic receptor


(Homo sapiens (Human))		BDBM50417347
PNG
(CHEMBL385310)
Show SMILES CC(Oc1ccccc1-c1ccsc1)C1=NCCN1 |t:16|
Show InChI InChI=1S/C15H16N2OS/c1-11(15-16-7-8-17-15)18-14-5-3-2-4-13(14)12-6-9-19-10-12/h2-6,9-11H,7-8H2,1H3,(H,16,17)
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n/an/an/an/a 93n/an/an/an/a



Universit£ degli Studi di Camerino

Curated by ChEMBL


Assay Description
Agonist activity at human adrenergic alpha-2C receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry

J Med Chem 47: 6160-73 (2004)


Article DOI: 10.1021/jm0408215
BindingDB Entry DOI: 10.7270/Q2B27Z13
More data for this
Ligand-Target Pair
Alpha-2A adrenergic receptor


(Homo sapiens (Human))		BDBM50473619
PNG
(CHEMBL130884)
Show SMILES CC(Nc1ccccc1-c1ccccc1)C1=NCCN1 |t:17|
Show InChI InChI=1S/C17H19N3/c1-13(17-18-11-12-19-17)20-16-10-6-5-9-15(16)14-7-3-2-4-8-14/h2-10,13,20H,11-12H2,1H3,(H,18,19)
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n/an/an/an/a 389n/an/an/an/a



Universit£ degli Studi di Camerino

Curated by ChEMBL


Assay Description
Agonist activity at human adrenergic alpha-2A receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry

J Med Chem 47: 6160-73 (2004)


Article DOI: 10.1021/jm0408215
BindingDB Entry DOI: 10.7270/Q2B27Z13
More data for this
Ligand-Target Pair
Alpha-2C adrenergic receptor


(Homo sapiens (Human))		BDBM50476175
PNG
(CHEMBL426900)
Show SMILES CC(Oc1ccccc1-c1ccc(C)cc1)C1=NCCN1 |t:18|
Show InChI InChI=1S/C18H20N2O/c1-13-7-9-15(10-8-13)16-5-3-4-6-17(16)21-14(2)18-19-11-12-20-18/h3-10,14H,11-12H2,1-2H3,(H,19,20)
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n/an/an/an/a 832n/an/an/an/a



Universit£ degli Studi di Camerino

Curated by ChEMBL


Assay Description
Agonist activity at human adrenergic alpha-2C receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry

J Med Chem 47: 6160-73 (2004)


Article DOI: 10.1021/jm0408215
BindingDB Entry DOI: 10.7270/Q2B27Z13
More data for this
Ligand-Target Pair
Alpha-2A adrenergic receptor


(Homo sapiens (Human))		BDBM50417347
PNG
(CHEMBL385310)
Show SMILES CC(Oc1ccccc1-c1ccsc1)C1=NCCN1 |t:16|
Show InChI InChI=1S/C15H16N2OS/c1-11(15-16-7-8-17-15)18-14-5-3-2-4-13(14)12-6-9-19-10-12/h2-6,9-11H,7-8H2,1H3,(H,16,17)
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n/an/an/an/a 76n/an/an/an/a



Universit£ degli Studi di Camerino

Curated by ChEMBL


Assay Description
Agonist activity at human adrenergic alpha-2A receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry

J Med Chem 47: 6160-73 (2004)


Article DOI: 10.1021/jm0408215
BindingDB Entry DOI: 10.7270/Q2B27Z13
More data for this
Ligand-Target Pair
Alpha-2C adrenergic receptor


(Homo sapiens (Human))		BDBM50476185
PNG
(CHEMBL222371)
Show SMILES CC(Oc1ccccc1-c1cccc(N)c1)C1=NCCN1 |t:18|
Show InChI InChI=1S/C17H19N3O/c1-12(17-19-9-10-20-17)21-16-8-3-2-7-15(16)13-5-4-6-14(18)11-13/h2-8,11-12H,9-10,18H2,1H3,(H,19,20)
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n/an/an/an/a 501n/an/an/an/a



Universit£ degli Studi di Camerino

Curated by ChEMBL


Assay Description
Agonist activity at human adrenergic alpha-2C receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry

J Med Chem 47: 6160-73 (2004)


Article DOI: 10.1021/jm0408215
BindingDB Entry DOI: 10.7270/Q2B27Z13
More data for this
Ligand-Target Pair
Alpha-2C adrenergic receptor


(Homo sapiens (Human))		BDBM50002905
PNG
(CHEMBL373535)
Show SMILES CC(Oc1ccccc1-c1cccnc1)C1=NCCN1 |t:17|
Show InChI InChI=1S/C16H17N3O/c1-12(16-18-9-10-19-16)20-15-7-3-2-6-14(15)13-5-4-8-17-11-13/h2-8,11-12H,9-10H2,1H3,(H,18,19)
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n/an/an/an/a 50n/an/an/an/a



Universit£ degli Studi di Camerino

Curated by ChEMBL


Assay Description
Agonist activity at human adrenergic alpha-2C receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry

J Med Chem 47: 6160-73 (2004)


Article DOI: 10.1021/jm0408215
BindingDB Entry DOI: 10.7270/Q2B27Z13
More data for this
Ligand-Target Pair
Alpha-2C adrenergic receptor


(Homo sapiens (Human))		BDBM50002903
PNG
(CHEMBL223836)
Show SMILES CC(Oc1ccccc1-c1cccc(F)c1)C1=NCCN1 |t:18|
Show InChI InChI=1S/C17H17FN2O/c1-12(17-19-9-10-20-17)21-16-8-3-2-7-15(16)13-5-4-6-14(18)11-13/h2-8,11-12H,9-10H2,1H3,(H,19,20)
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n/an/an/an/a 60n/an/an/an/a



Universit£ degli Studi di Camerino

Curated by ChEMBL


Assay Description
Agonist activity at human adrenergic alpha-2C receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry

J Med Chem 47: 6160-73 (2004)


Article DOI: 10.1021/jm0408215
BindingDB Entry DOI: 10.7270/Q2B27Z13
More data for this
Ligand-Target Pair
Alpha-2C adrenergic receptor


(Homo sapiens (Human))		BDBM50476173
PNG
(CHEMBL222973)
Show SMILES CC(Oc1ccccc1-c1cccc(C)c1)C1=NCCN1 |t:18|
Show InChI InChI=1S/C18H20N2O/c1-13-6-5-7-15(12-13)16-8-3-4-9-17(16)21-14(2)18-19-10-11-20-18/h3-9,12,14H,10-11H2,1-2H3,(H,19,20)
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n/an/an/an/a 1.59E+3n/an/an/an/a



Universit£ degli Studi di Camerino

Curated by ChEMBL


Assay Description
Agonist activity at human adrenergic alpha-2C receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry

J Med Chem 47: 6160-73 (2004)


Article DOI: 10.1021/jm0408215
BindingDB Entry DOI: 10.7270/Q2B27Z13
More data for this
Ligand-Target Pair
Alpha-2C adrenergic receptor


(Homo sapiens (Human))		BDBM50029051
PNG
((-)-arterenol | (-)-noradrenaline | (-)-norepineph...)
Show SMILES NC[C@H](O)c1ccc(O)c(O)c1 |r|
Show InChI InChI=1S/C8H11NO3/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,8,10-12H,4,9H2/t8-/m0/s1
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n/an/an/an/a 794n/an/an/an/a



Universit£ degli Studi di Camerino

Curated by ChEMBL


Assay Description
Agonist activity at human adrenergic alpha-2C receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry

J Med Chem 47: 6160-73 (2004)


Article DOI: 10.1021/jm0408215
BindingDB Entry DOI: 10.7270/Q2B27Z13
More data for this
Ligand-Target Pair
Alpha-2C adrenergic receptor


(Homo sapiens (Human))		BDBM50476188
PNG
(CHEMBL223830)
Show SMILES CC(Oc1ccccc1-c1ccccc1C)C1=NCCN1 |t:18|
Show InChI InChI=1S/C18H20N2O/c1-13-7-3-4-8-15(13)16-9-5-6-10-17(16)21-14(2)18-19-11-12-20-18/h3-10,14H,11-12H2,1-2H3,(H,19,20)
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n/an/an/an/a 363n/an/an/an/a



Universit£ degli Studi di Camerino

Curated by ChEMBL


Assay Description
Agonist activity at human adrenergic alpha-2C receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry

J Med Chem 47: 6160-73 (2004)


Article DOI: 10.1021/jm0408215
BindingDB Entry DOI: 10.7270/Q2B27Z13
More data for this
Ligand-Target Pair
Alpha-2C adrenergic receptor


(Homo sapiens (Human))		BDBM50002904
PNG
(CHEMBL222928)
Show SMILES CC(Oc1ccccc1-c1cccc(c1)[N+]([O-])=O)C1=NCCN1 |t:20|
Show InChI InChI=1S/C17H17N3O3/c1-12(17-18-9-10-19-17)23-16-8-3-2-7-15(16)13-5-4-6-14(11-13)20(21)22/h2-8,11-12H,9-10H2,1H3,(H,18,19)
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n/an/an/an/a 100n/an/an/an/a



Universit£ degli Studi di Camerino

Curated by ChEMBL


Assay Description
Agonist activity at human adrenergic alpha-2C receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry

J Med Chem 47: 6160-73 (2004)


Article DOI: 10.1021/jm0408215
BindingDB Entry DOI: 10.7270/Q2B27Z13
More data for this
Ligand-Target Pair
Alpha-2A adrenergic receptor


(Homo sapiens (Human))		BDBM50476185
PNG
(CHEMBL222371)
Show SMILES CC(Oc1ccccc1-c1cccc(N)c1)C1=NCCN1 |t:18|
Show InChI InChI=1S/C17H19N3O/c1-12(17-19-9-10-20-17)21-16-8-3-2-7-15(16)13-5-4-6-14(18)11-13/h2-8,11-12H,9-10,18H2,1H3,(H,19,20)
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n/an/an/an/a 257n/an/an/an/a



Universit£ degli Studi di Camerino

Curated by ChEMBL


Assay Description
Agonist activity at human adrenergic alpha-2A receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry

J Med Chem 47: 6160-73 (2004)


Article DOI: 10.1021/jm0408215
BindingDB Entry DOI: 10.7270/Q2B27Z13
More data for this
Ligand-Target Pair
Alpha-2C adrenergic receptor


(Homo sapiens (Human))		BDBM50476186
PNG
(CHEMBL222933)
Show SMILES C1CN=C(N1)C1OC1c1ccccc1-c1ccccc1 |c:2|
Show InChI InChI=1S/C17H16N2O/c1-2-6-12(7-3-1)13-8-4-5-9-14(13)15-16(20-15)17-18-10-11-19-17/h1-9,15-16H,10-11H2,(H,18,19)
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n/an/an/an/a 2.69E+3n/an/an/an/a



Universit£ degli Studi di Camerino

Curated by ChEMBL


Assay Description
Agonist activity at human adrenergic alpha-2C receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry

J Med Chem 47: 6160-73 (2004)


Article DOI: 10.1021/jm0408215
BindingDB Entry DOI: 10.7270/Q2B27Z13
More data for this
Ligand-Target Pair
Alpha-2B adrenergic receptor


(Homo sapiens (Human))		BDBM50476178
PNG
(CHEMBL223829)
Show SMILES CC(Oc1ccccc1-c1cccs1)C1=NCCN1 |t:16|
Show InChI InChI=1S/C15H16N2OS/c1-11(15-16-8-9-17-15)18-13-6-3-2-5-12(13)14-7-4-10-19-14/h2-7,10-11H,8-9H2,1H3,(H,16,17)
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n/an/an/an/a 1.00E+3n/an/an/an/a



Universit£ degli Studi di Camerino

Curated by ChEMBL


Assay Description
Agonist activity at human adrenergic alpha-2B receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry

J Med Chem 47: 6160-73 (2004)


Article DOI: 10.1021/jm0408215
BindingDB Entry DOI: 10.7270/Q2B27Z13
More data for this
Ligand-Target Pair
Alpha-2B adrenergic receptor


(Homo sapiens (Human))		BDBM50473619
PNG
(CHEMBL130884)
Show SMILES CC(Nc1ccccc1-c1ccccc1)C1=NCCN1 |t:17|
Show InChI InChI=1S/C17H19N3/c1-13(17-18-11-12-19-17)20-16-10-6-5-9-15(16)14-7-3-2-4-8-14/h2-10,13,20H,11-12H2,1H3,(H,18,19)
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n/an/an/an/a 3.80E+3n/an/an/an/a



Universit£ degli Studi di Camerino

Curated by ChEMBL


Assay Description
Agonist activity at human adrenergic alpha-2B receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry

J Med Chem 47: 6160-73 (2004)


Article DOI: 10.1021/jm0408215
BindingDB Entry DOI: 10.7270/Q2B27Z13
More data for this
Ligand-Target Pair
Alpha-2B adrenergic receptor


(Homo sapiens (Human))		BDBM50002905
PNG
(CHEMBL373535)
Show SMILES CC(Oc1ccccc1-c1cccnc1)C1=NCCN1 |t:17|
Show InChI InChI=1S/C16H17N3O/c1-12(16-18-9-10-19-16)20-15-7-3-2-6-14(15)13-5-4-8-17-11-13/h2-8,11-12H,9-10H2,1H3,(H,18,19)
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n/an/an/an/a 1.00E+3n/an/an/an/a



Universit£ degli Studi di Camerino

Curated by ChEMBL


Assay Description
Agonist activity at human adrenergic alpha-2B receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry

J Med Chem 47: 6160-73 (2004)


Article DOI: 10.1021/jm0408215
BindingDB Entry DOI: 10.7270/Q2B27Z13
More data for this
Ligand-Target Pair
Alpha-2C adrenergic receptor


(Homo sapiens (Human))		BDBM50417350
PNG
(CHEMBL374584)
Show SMILES CC(Oc1ccccc1-c1cccc(O)c1)C1=NCCN1 |t:18|
Show InChI InChI=1S/C17H18N2O2/c1-12(17-18-9-10-19-17)21-16-8-3-2-7-15(16)13-5-4-6-14(20)11-13/h2-8,11-12,20H,9-10H2,1H3,(H,18,19)
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n/an/an/an/a 47n/an/an/an/a



Universit£ degli Studi di Camerino

Curated by ChEMBL


Assay Description
Agonist activity at human adrenergic alpha-2C receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry

J Med Chem 47: 6160-73 (2004)


Article DOI: 10.1021/jm0408215
BindingDB Entry DOI: 10.7270/Q2B27Z13
More data for this
Ligand-Target Pair
Alpha-2C adrenergic receptor


(Homo sapiens (Human))		BDBM50002904
PNG
(CHEMBL222928)
Show SMILES CC(Oc1ccccc1-c1cccc(c1)[N+]([O-])=O)C1=NCCN1 |t:20|
Show InChI InChI=1S/C17H17N3O3/c1-12(17-18-9-10-19-17)23-16-8-3-2-7-15(16)13-5-4-6-14(11-13)20(21)22/h2-8,11-12H,9-10H2,1H3,(H,18,19)
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n/an/an/an/a 158n/an/an/an/a



Universit£ degli Studi di Camerino

Curated by ChEMBL


Assay Description
Agonist activity at human adrenergic Alpha-2C receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation

J Med Chem 47: 6160-73 (2004)


Article DOI: 10.1021/jm0408215
BindingDB Entry DOI: 10.7270/Q2B27Z13
More data for this
Ligand-Target Pair
Alpha-2A adrenergic receptor


(Homo sapiens (Human))		BDBM50412250
PNG
(CHEMBL128168)
Show SMILES CC(Oc1ccccc1-c1ccccc1)C1=NCCN1 |t:17|
Show InChI InChI=1S/C17H18N2O/c1-13(17-18-11-12-19-17)20-16-10-6-5-9-15(16)14-7-3-2-4-8-14/h2-10,13H,11-12H2,1H3,(H,18,19)
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n/an/an/an/a 115n/an/an/an/a



Universit£ degli Studi di Camerino

Curated by ChEMBL


Assay Description
Agonist activity at human adrenergic alpha-2A receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry

J Med Chem 47: 6160-73 (2004)


Article DOI: 10.1021/jm0408215
BindingDB Entry DOI: 10.7270/Q2B27Z13
More data for this
Ligand-Target Pair
Alpha-2B adrenergic receptor


(Homo sapiens (Human))		BDBM50029051
PNG
((-)-arterenol | (-)-noradrenaline | (-)-norepineph...)
Show SMILES NC[C@H](O)c1ccc(O)c(O)c1 |r|
Show InChI InChI=1S/C8H11NO3/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,8,10-12H,4,9H2/t8-/m0/s1
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n/an/an/an/a 62n/an/an/an/a



Universit£ degli Studi di Camerino

Curated by ChEMBL


Assay Description
Agonist activity at human adrenergic alpha-2B receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry

J Med Chem 47: 6160-73 (2004)


Article DOI: 10.1021/jm0408215
BindingDB Entry DOI: 10.7270/Q2B27Z13
More data for this
Ligand-Target Pair
Alpha-2A adrenergic receptor


(Homo sapiens (Human))		BDBM50029051
PNG
((-)-arterenol | (-)-noradrenaline | (-)-norepineph...)
Show SMILES NC[C@H](O)c1ccc(O)c(O)c1 |r|
Show InChI InChI=1S/C8H11NO3/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,8,10-12H,4,9H2/t8-/m0/s1
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n/an/an/an/a 372n/an/an/an/a



Universit£ degli Studi di Camerino

Curated by ChEMBL


Assay Description
Agonist activity at human adrenergic alpha-2A receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry

J Med Chem 47: 6160-73 (2004)


Article DOI: 10.1021/jm0408215
BindingDB Entry DOI: 10.7270/Q2B27Z13
More data for this
Ligand-Target Pair
Alpha-2A adrenergic receptor


(Homo sapiens (Human))		BDBM50002905
PNG
(CHEMBL373535)
Show SMILES CC(Oc1ccccc1-c1cccnc1)C1=NCCN1 |t:17|
Show InChI InChI=1S/C16H17N3O/c1-12(16-18-9-10-19-16)20-15-7-3-2-6-14(15)13-5-4-8-17-11-13/h2-8,11-12H,9-10H2,1H3,(H,18,19)
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n/an/an/an/a 589n/an/an/an/a



Universit£ degli Studi di Camerino

Curated by ChEMBL


Assay Description
Agonist activity at human adrenergic alpha-2A receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation

J Med Chem 47: 6160-73 (2004)


Article DOI: 10.1021/jm0408215
BindingDB Entry DOI: 10.7270/Q2B27Z13
More data for this
Ligand-Target Pair
Alpha-2B adrenergic receptor


(Homo sapiens (Human))		BDBM50417350
PNG
(CHEMBL374584)
Show SMILES CC(Oc1ccccc1-c1cccc(O)c1)C1=NCCN1 |t:18|
Show InChI InChI=1S/C17H18N2O2/c1-12(17-18-9-10-19-17)21-16-8-3-2-7-15(16)13-5-4-6-14(20)11-13/h2-8,11-12,20H,9-10H2,1H3,(H,18,19)
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n/an/an/an/a 5.25E+3n/an/an/an/a



Universit£ degli Studi di Camerino

Curated by ChEMBL


Assay Description
Agonist activity at human adrenergic alpha-2B receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry

J Med Chem 47: 6160-73 (2004)


Article DOI: 10.1021/jm0408215
BindingDB Entry DOI: 10.7270/Q2B27Z13
More data for this
Ligand-Target Pair
Alpha-2C adrenergic receptor


(Homo sapiens (Human))		BDBM50412250
PNG
(CHEMBL128168)
Show SMILES CC(Oc1ccccc1-c1ccccc1)C1=NCCN1 |t:17|
Show InChI InChI=1S/C17H18N2O/c1-13(17-18-11-12-19-17)20-16-10-6-5-9-15(16)14-7-3-2-4-8-14/h2-10,13H,11-12H2,1H3,(H,18,19)
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n/an/an/an/a 58n/an/an/an/a



Universit£ degli Studi di Camerino

Curated by ChEMBL


Assay Description
Agonist activity at human adrenergic alpha-2C receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry

J Med Chem 47: 6160-73 (2004)


Article DOI: 10.1021/jm0408215
BindingDB Entry DOI: 10.7270/Q2B27Z13
More data for this
Ligand-Target Pair
Alpha-2A adrenergic receptor


(Homo sapiens (Human))		BDBM50002903
PNG
(CHEMBL223836)
Show SMILES CC(Oc1ccccc1-c1cccc(F)c1)C1=NCCN1 |t:18|
Show InChI InChI=1S/C17H17FN2O/c1-12(17-19-9-10-20-17)21-16-8-3-2-7-15(16)13-5-4-6-14(18)11-13/h2-8,11-12H,9-10H2,1H3,(H,19,20)
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n/an/an/an/a 105n/an/an/an/a



Universit£ degli Studi di Camerino

Curated by ChEMBL


Assay Description
Agonist activity at human adrenergic alpha-2A receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry

J Med Chem 47: 6160-73 (2004)


Article DOI: 10.1021/jm0408215
BindingDB Entry DOI: 10.7270/Q2B27Z13
More data for this
Ligand-Target Pair
Alpha-2C adrenergic receptor


(Homo sapiens (Human))		BDBM50473619
PNG
(CHEMBL130884)
Show SMILES CC(Nc1ccccc1-c1ccccc1)C1=NCCN1 |t:17|
Show InChI InChI=1S/C17H19N3/c1-13(17-18-11-12-19-17)20-16-10-6-5-9-15(16)14-7-3-2-4-8-14/h2-10,13,20H,11-12H2,1H3,(H,18,19)
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n/an/an/an/a 93n/an/an/an/a



Universit£ degli Studi di Camerino

Curated by ChEMBL


Assay Description
Agonist activity at human adrenergic alpha-2C receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry

J Med Chem 47: 6160-73 (2004)


Article DOI: 10.1021/jm0408215
BindingDB Entry DOI: 10.7270/Q2B27Z13
More data for this
Ligand-Target Pair
Alpha-2A adrenergic receptor


(Homo sapiens (Human))		BDBM50002905
PNG
(CHEMBL373535)
Show SMILES CC(Oc1ccccc1-c1cccnc1)C1=NCCN1 |t:17|
Show InChI InChI=1S/C16H17N3O/c1-12(16-18-9-10-19-16)20-15-7-3-2-6-14(15)13-5-4-8-17-11-13/h2-8,11-12H,9-10H2,1H3,(H,18,19)
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n/an/an/an/a 316n/an/an/an/a



Universit£ degli Studi di Camerino

Curated by ChEMBL


Assay Description
Agonist activity at human adrenergic alpha-2A receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry

J Med Chem 47: 6160-73 (2004)


Article DOI: 10.1021/jm0408215
BindingDB Entry DOI: 10.7270/Q2B27Z13
More data for this
Ligand-Target Pair
Alpha-2A adrenergic receptor


(Homo sapiens (Human))		BDBM50476178
PNG
(CHEMBL223829)
Show SMILES CC(Oc1ccccc1-c1cccs1)C1=NCCN1 |t:16|
Show InChI InChI=1S/C15H16N2OS/c1-11(15-16-8-9-17-15)18-13-6-3-2-5-12(13)14-7-4-10-19-14/h2-7,10-11H,8-9H2,1H3,(H,16,17)
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n/an/an/an/a 42n/an/an/an/a



Universit£ degli Studi di Camerino

Curated by ChEMBL


Assay Description
Agonist activity at human adrenergic alpha-2A receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry

J Med Chem 47: 6160-73 (2004)


Article DOI: 10.1021/jm0408215
BindingDB Entry DOI: 10.7270/Q2B27Z13
More data for this
Ligand-Target Pair
Alpha-2A adrenergic receptor


(Homo sapiens (Human))		BDBM50476186
PNG
(CHEMBL222933)
Show SMILES C1CN=C(N1)C1OC1c1ccccc1-c1ccccc1 |c:2|
Show InChI InChI=1S/C17H16N2O/c1-2-6-12(7-3-1)13-8-4-5-9-14(13)15-16(20-15)17-18-10-11-19-17/h1-9,15-16H,10-11H2,(H,18,19)
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n/an/an/an/a 3.47E+3n/an/an/an/a



Universit£ degli Studi di Camerino

Curated by ChEMBL


Assay Description
Agonist activity at human adrenergic alpha-2A receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry

J Med Chem 47: 6160-73 (2004)


Article DOI: 10.1021/jm0408215
BindingDB Entry DOI: 10.7270/Q2B27Z13
More data for this
Ligand-Target Pair
Alpha-2C adrenergic receptor


(Homo sapiens (Human))		BDBM50002905
PNG
(CHEMBL373535)
Show SMILES CC(Oc1ccccc1-c1cccnc1)C1=NCCN1 |t:17|
Show InChI InChI=1S/C16H17N3O/c1-12(16-18-9-10-19-16)20-15-7-3-2-6-14(15)13-5-4-8-17-11-13/h2-8,11-12H,9-10H2,1H3,(H,18,19)
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n/an/an/an/a 40n/an/an/an/a



Universit£ degli Studi di Camerino

Curated by ChEMBL


Assay Description
Agonist activity at human adrenergic Alpha-2C receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation

J Med Chem 47: 6160-73 (2004)


Article DOI: 10.1021/jm0408215
BindingDB Entry DOI: 10.7270/Q2B27Z13
More data for this
Ligand-Target Pair
Alpha-2C adrenergic receptor


(Homo sapiens (Human))		BDBM50476178
PNG
(CHEMBL223829)
Show SMILES CC(Oc1ccccc1-c1cccs1)C1=NCCN1 |t:16|
Show InChI InChI=1S/C15H16N2OS/c1-11(15-16-8-9-17-15)18-13-6-3-2-5-12(13)14-7-4-10-19-14/h2-7,10-11H,8-9H2,1H3,(H,16,17)
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n/an/an/an/a 59n/an/an/an/a



Universit£ degli Studi di Camerino

Curated by ChEMBL


Assay Description
Agonist activity at human adrenergic alpha-2C receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry

J Med Chem 47: 6160-73 (2004)


Article DOI: 10.1021/jm0408215
BindingDB Entry DOI: 10.7270/Q2B27Z13
More data for this
Ligand-Target Pair
Alpha-2B adrenergic receptor


(Homo sapiens (Human))		BDBM50412250
PNG
(CHEMBL128168)
Show SMILES CC(Oc1ccccc1-c1ccccc1)C1=NCCN1 |t:17|
Show InChI InChI=1S/C17H18N2O/c1-13(17-18-11-12-19-17)20-16-10-6-5-9-15(16)14-7-3-2-4-8-14/h2-10,13H,11-12H2,1H3,(H,18,19)
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n/an/an/an/a 646n/an/an/an/a



Universit£ degli Studi di Camerino

Curated by ChEMBL


Assay Description
Agonist activity at human adrenergic alpha-2B receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry

J Med Chem 47: 6160-73 (2004)


Article DOI: 10.1021/jm0408215
BindingDB Entry DOI: 10.7270/Q2B27Z13
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%