Found 10 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50162884
(3-[[2-(4-Fluoro-phenyl)-ethyl]-(4-phenoxy-benzyl)-...)Show SMILES OC(=O)CC(N(CCc1ccc(F)cc1)Cc1ccc(Oc2ccccc2)cc1)c1cnc[nH]1 Show InChI InChI=1S/C27H26FN3O3/c28-22-10-6-20(7-11-22)14-15-31(26(16-27(32)33)25-17-29-19-30-25)18-21-8-12-24(13-9-21)34-23-4-2-1-3-5-23/h1-13,17,19,26H,14-16,18H2,(H,29,30)(H,32,33) | PDB
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PC cid
PC sid
UniChem
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| Article
PubMed
| n/a | n/a | 90 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Research Foundation
Curated by ChEMBL
| Assay Description
Inhibition of Geranylgeranyl transferase type I |
Bioorg Med Chem Lett 15: 1713-9 (2005)
Article DOI: 10.1016/j.bmcl.2005.01.042
BindingDB Entry DOI: 10.7270/Q24F1Q7J |
More data for this
Ligand-Target Pair | |
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50162889
(2-[4-(2-Amino-3-mercapto-propylamino)-2-naphthalen...)Show SMILES COC(=O)C(CC(C)C)NC(=O)c1ccc(NCC(N)CS)cc1-c1cccc2ccccc12 Show InChI InChI=1S/C27H33N3O3S/c1-17(2)13-25(27(32)33-3)30-26(31)23-12-11-20(29-15-19(28)16-34)14-24(23)22-10-6-8-18-7-4-5-9-21(18)22/h4-12,14,17,19,25,29,34H,13,15-16,28H2,1-3H3,(H,30,31) | PDB
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PC cid
PC sid
UniChem
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| Article
PubMed
| n/a | n/a | 150 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Research Foundation
Curated by ChEMBL
| Assay Description
Inhibition of Geranylgeranyl transferase type I |
Bioorg Med Chem Lett 15: 1713-9 (2005)
Article DOI: 10.1016/j.bmcl.2005.01.042
BindingDB Entry DOI: 10.7270/Q24F1Q7J |
More data for this
Ligand-Target Pair | |
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50162883
(CHEMBL425159 | [2-(4-Bromo-phenyl)-ethyl]-(1H-imid...)Show SMILES Brc1ccc(CCN(Cc2cnc[nH]2)Cc2ccc(Oc3ccccc3)cc2)cc1 Show InChI InChI=1S/C25H24BrN3O/c26-22-10-6-20(7-11-22)14-15-29(18-23-16-27-19-28-23)17-21-8-12-25(13-9-21)30-24-4-2-1-3-5-24/h1-13,16,19H,14-15,17-18H2,(H,27,28) | PDB
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PubMed
| n/a | n/a | 256 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Research Foundation
Curated by ChEMBL
| Assay Description
Inhibition of Geranylgeranyl transferase type I |
Bioorg Med Chem Lett 15: 1713-9 (2005)
Article DOI: 10.1016/j.bmcl.2005.01.042
BindingDB Entry DOI: 10.7270/Q24F1Q7J |
More data for this
Ligand-Target Pair | |
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50162888
(CHEMBL426604 | [2-(4-Fluoro-phenyl)-ethyl]-(1H-imi...)Show SMILES Fc1ccc(CCN(Cc2cnc[nH]2)Cc2ccc(Oc3ccccc3)cc2)cc1 Show InChI InChI=1S/C25H24FN3O/c26-22-10-6-20(7-11-22)14-15-29(18-23-16-27-19-28-23)17-21-8-12-25(13-9-21)30-24-4-2-1-3-5-24/h1-13,16,19H,14-15,17-18H2,(H,27,28) | PDB
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PubMed
| n/a | n/a | 460 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Research Foundation
Curated by ChEMBL
| Assay Description
Inhibition of Geranylgeranyl transferase type I |
Bioorg Med Chem Lett 15: 1713-9 (2005)
Article DOI: 10.1016/j.bmcl.2005.01.042
BindingDB Entry DOI: 10.7270/Q24F1Q7J |
More data for this
Ligand-Target Pair | |
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50162882
(3-(1H-Imidazol-4-yl)-3-[(4-phenoxy-benzyl)-(4-phen...)Show SMILES OC(=O)CC(N(CCCCc1ccccc1)Cc1ccc(Oc2ccccc2)cc1)c1cnc[nH]1 Show InChI InChI=1S/C29H31N3O3/c33-29(34)19-28(27-20-30-22-31-27)32(18-8-7-11-23-9-3-1-4-10-23)21-24-14-16-26(17-15-24)35-25-12-5-2-6-13-25/h1-6,9-10,12-17,20,22,28H,7-8,11,18-19,21H2,(H,30,31)(H,33,34) | PDB
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| n/a | n/a | 860 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Research Foundation
Curated by ChEMBL
| Assay Description
Inhibition of Geranylgeranyl transferase type I |
Bioorg Med Chem Lett 15: 1713-9 (2005)
Article DOI: 10.1016/j.bmcl.2005.01.042
BindingDB Entry DOI: 10.7270/Q24F1Q7J |
More data for this
Ligand-Target Pair | |
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50162885
(3-[Biphenyl-4-ylmethyl-(2-thiophen-2-yl-ethyl)-ami...)Show SMILES OC(=O)CC(N(CCc1cccs1)Cc1ccc(cc1)-c1ccccc1)c1cnc[nH]1 Show InChI InChI=1S/C25H25N3O2S/c29-25(30)15-24(23-16-26-18-27-23)28(13-12-22-7-4-14-31-22)17-19-8-10-21(11-9-19)20-5-2-1-3-6-20/h1-11,14,16,18,24H,12-13,15,17H2,(H,26,27)(H,29,30) | PDB
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PC cid
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| Article
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| n/a | n/a | 1.07E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Research Foundation
Curated by ChEMBL
| Assay Description
Inhibition of Geranylgeranyl transferase type I |
Bioorg Med Chem Lett 15: 1713-9 (2005)
Article DOI: 10.1016/j.bmcl.2005.01.042
BindingDB Entry DOI: 10.7270/Q24F1Q7J |
More data for this
Ligand-Target Pair | |
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50162887
(3-{(4-Butoxy-benzenesulfonyl)-[2-(4-fluoro-phenyl)...)Show SMILES CCCCOc1ccc(cc1)S(=O)(=O)N(CCc1ccc(F)cc1)C(CC(O)=O)c1cnc[nH]1 Show InChI InChI=1S/C24H28FN3O5S/c1-2-3-14-33-20-8-10-21(11-9-20)34(31,32)28(13-12-18-4-6-19(25)7-5-18)23(15-24(29)30)22-16-26-17-27-22/h4-11,16-17,23H,2-3,12-15H2,1H3,(H,26,27)(H,29,30) | PDB
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| n/a | n/a | 1.07E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Research Foundation
Curated by ChEMBL
| Assay Description
Inhibition of Geranylgeranyl transferase type I |
Bioorg Med Chem Lett 15: 1713-9 (2005)
Article DOI: 10.1016/j.bmcl.2005.01.042
BindingDB Entry DOI: 10.7270/Q24F1Q7J |
More data for this
Ligand-Target Pair | |
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50162886
(3-{Biphenyl-4-ylmethyl-[2-(4-fluoro-phenyl)-ethyl]...)Show SMILES OC(=O)CC(N(CCc1ccc(F)cc1)Cc1ccc(cc1)-c1ccccc1)c1cnc[nH]1 Show InChI InChI=1S/C27H26FN3O2/c28-24-12-8-20(9-13-24)14-15-31(26(16-27(32)33)25-17-29-19-30-25)18-21-6-10-23(11-7-21)22-4-2-1-3-5-22/h1-13,17,19,26H,14-16,18H2,(H,29,30)(H,32,33) | PDB
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PC cid
PC sid
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PubMed
| n/a | n/a | 1.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Research Foundation
Curated by ChEMBL
| Assay Description
Inhibition of Geranylgeranyl transferase type I |
Bioorg Med Chem Lett 15: 1713-9 (2005)
Article DOI: 10.1016/j.bmcl.2005.01.042
BindingDB Entry DOI: 10.7270/Q24F1Q7J |
More data for this
Ligand-Target Pair | |
Dimer of Protein farnesyltransferase subunit beta
(Homo sapiens (Human)) | BDBM50162883
(CHEMBL425159 | [2-(4-Bromo-phenyl)-ethyl]-(1H-imid...)Show SMILES Brc1ccc(CCN(Cc2cnc[nH]2)Cc2ccc(Oc3ccccc3)cc2)cc1 Show InChI InChI=1S/C25H24BrN3O/c26-22-10-6-20(7-11-22)14-15-29(18-23-16-27-19-28-23)17-21-8-12-25(13-9-21)30-24-4-2-1-3-5-24/h1-13,16,19H,14-15,17-18H2,(H,27,28) | PDB
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PC cid
PC sid
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PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Research Foundation
Curated by ChEMBL
| Assay Description
Inhibition of Farnesyltransferase |
Bioorg Med Chem Lett 15: 1713-9 (2005)
Article DOI: 10.1016/j.bmcl.2005.01.042
BindingDB Entry DOI: 10.7270/Q24F1Q7J |
More data for this
Ligand-Target Pair | |
Dimer of Protein farnesyltransferase subunit beta
(Homo sapiens (Human)) | BDBM50162888
(CHEMBL426604 | [2-(4-Fluoro-phenyl)-ethyl]-(1H-imi...)Show SMILES Fc1ccc(CCN(Cc2cnc[nH]2)Cc2ccc(Oc3ccccc3)cc2)cc1 Show InChI InChI=1S/C25H24FN3O/c26-22-10-6-20(7-11-22)14-15-29(18-23-16-27-19-28-23)17-21-8-12-25(13-9-21)30-24-4-2-1-3-5-24/h1-13,16,19H,14-15,17-18H2,(H,27,28) | PDB
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PC cid
PC sid
UniChem
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PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Research Foundation
Curated by ChEMBL
| Assay Description
Inhibition of Farnesyltransferase |
Bioorg Med Chem Lett 15: 1713-9 (2005)
Article DOI: 10.1016/j.bmcl.2005.01.042
BindingDB Entry DOI: 10.7270/Q24F1Q7J |
More data for this
Ligand-Target Pair | |
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