Affinity Data by PubMed id=16337119

PubMed code 16337119

Found 48 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Thymidine phosphorylase (Escherichia coli)	BDBM20033 (6-(azetidin-1-yl)-5-bromo-1,3-diazinane-2,4-dione ...) Show SMILES Brc1c([nH]c(=O)[nH]c1=O)N1CCC1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Academy of Sciences of the Czech Republic					Assay Description The enzyme reaction was started by the addition of enzyme to the reaction mixture containing substrate and test compounds. The reaction was stopped b...				Bioorg Med Chem Lett 16: 1335-7 (2006) Article DOI: 10.1016/j.bmcl.2005.11.050 BindingDB Entry DOI: 10.7270/Q2QR4VCH
Academy of Sciences of the Czech Republic					More data for this Ligand-Target Pair
Thymidine phosphorylase (Escherichia coli)	BDBM20051 (5-bromo-6-[4-(5-bromo-2,6-dioxo-1,2,3,6-tetrahydro...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
Academy of Sciences of the Czech Republic					Assay Description The enzyme reaction was started by the addition of enzyme to the reaction mixture containing substrate and test compounds. The reaction was stopped b...				Bioorg Med Chem Lett 16: 1335-7 (2006) Article DOI: 10.1016/j.bmcl.2005.11.050 BindingDB Entry DOI: 10.7270/Q2QR4VCH
Academy of Sciences of the Czech Republic					More data for this Ligand-Target Pair
Thymidine phosphorylase (Escherichia coli)	BDBM20052 (5-bromo-6-({2-[(5-bromo-2,6-dioxo-1,2,3,6-tetrahyd...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Academy of Sciences of the Czech Republic					Assay Description The enzyme reaction was started by the addition of enzyme to the reaction mixture containing substrate and test compounds. The reaction was stopped b...				Bioorg Med Chem Lett 16: 1335-7 (2006) Article DOI: 10.1016/j.bmcl.2005.11.050 BindingDB Entry DOI: 10.7270/Q2QR4VCH
Academy of Sciences of the Czech Republic					More data for this Ligand-Target Pair
Thymidine phosphorylase (Homo sapiens (Human))	BDBM20052 (5-bromo-6-({2-[(5-bromo-2,6-dioxo-1,2,3,6-tetrahyd...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.40E+3	n/a	n/a	n/a	n/a	6.4	37
Academy of Sciences of the Czech Republic					Assay Description The enzyme reaction was started by the addition of enzyme to the reaction mixture containing substrate and test compounds. The reaction was stopped b...				Bioorg Med Chem Lett 16: 1335-7 (2006) Article DOI: 10.1016/j.bmcl.2005.11.050 BindingDB Entry DOI: 10.7270/Q2QR4VCH
Academy of Sciences of the Czech Republic					More data for this Ligand-Target Pair
Thymidine phosphorylase (Escherichia coli)	BDBM20036 (5-bromo-6-(cyclopropylamino)-1,3-diazinane-2,4-dio...) Show SMILES Brc1c(NC2CC2)[nH]c(=O)[nH]c1=O Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Academy of Sciences of the Czech Republic					Assay Description The enzyme reaction was started by the addition of enzyme to the reaction mixture containing substrate and test compounds. The reaction was stopped b...				Bioorg Med Chem Lett 16: 1335-7 (2006) Article DOI: 10.1016/j.bmcl.2005.11.050 BindingDB Entry DOI: 10.7270/Q2QR4VCH
Academy of Sciences of the Czech Republic					More data for this Ligand-Target Pair
Thymidine phosphorylase (Homo sapiens (Human))	BDBM20034 (5-bromo-6-hydrazinyl-1,3-diazinane-2,4-dione \| ura...) Show SMILES NNc1[nH]c(=O)[nH]c(=O)c1Br Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.80E+3	n/a	n/a	n/a	n/a	6.4	37
Academy of Sciences of the Czech Republic					Assay Description The enzyme reaction was started by the addition of enzyme to the reaction mixture containing substrate and test compounds. The reaction was stopped b...				Bioorg Med Chem Lett 16: 1335-7 (2006) Article DOI: 10.1016/j.bmcl.2005.11.050 BindingDB Entry DOI: 10.7270/Q2QR4VCH
Academy of Sciences of the Czech Republic					More data for this Ligand-Target Pair
Thymidine phosphorylase (Homo sapiens (Human))	BDBM20051 (5-bromo-6-[4-(5-bromo-2,6-dioxo-1,2,3,6-tetrahydro...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.00E+3	n/a	n/a	n/a	n/a	6.4	37
Academy of Sciences of the Czech Republic					Assay Description The enzyme reaction was started by the addition of enzyme to the reaction mixture containing substrate and test compounds. The reaction was stopped b...				Bioorg Med Chem Lett 16: 1335-7 (2006) Article DOI: 10.1016/j.bmcl.2005.11.050 BindingDB Entry DOI: 10.7270/Q2QR4VCH
Academy of Sciences of the Czech Republic					More data for this Ligand-Target Pair
Thymidine phosphorylase (Escherichia coli)	BDBM20030 (6-amino-5-chloro-1,3-diazinane-2,4-dione \| 6-amino...) Show SMILES Nc1[nH]c(=O)[nH]c(=O)c1Cl Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	4.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Academy of Sciences of the Czech Republic					Assay Description The enzyme reaction was started by the addition of enzyme to the reaction mixture containing substrate and test compounds. The reaction was stopped b...				Bioorg Med Chem Lett 16: 1335-7 (2006) Article DOI: 10.1016/j.bmcl.2005.11.050 BindingDB Entry DOI: 10.7270/Q2QR4VCH
Academy of Sciences of the Czech Republic					More data for this Ligand-Target Pair
Thymidine phosphorylase (Escherichia coli)	BDBM20047 (5-chloro-6-[2-(hydroxymethyl)piperidin-1-yl]-1,3-d...) Show SMILES OCC1CCCCN1c1[nH]c(=O)[nH]c(=O)c1Cl Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
Academy of Sciences of the Czech Republic					Assay Description The enzyme reaction was started by the addition of enzyme to the reaction mixture containing substrate and test compounds. The reaction was stopped b...				Bioorg Med Chem Lett 16: 1335-7 (2006) Article DOI: 10.1016/j.bmcl.2005.11.050 BindingDB Entry DOI: 10.7270/Q2QR4VCH
Academy of Sciences of the Czech Republic					More data for this Ligand-Target Pair
Thymidine phosphorylase (Escherichia coli)	BDBM20034 (5-bromo-6-hydrazinyl-1,3-diazinane-2,4-dione \| ura...) Show SMILES NNc1[nH]c(=O)[nH]c(=O)c1Br Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
Academy of Sciences of the Czech Republic					Assay Description The enzyme reaction was started by the addition of enzyme to the reaction mixture containing substrate and test compounds. The reaction was stopped b...				Bioorg Med Chem Lett 16: 1335-7 (2006) Article DOI: 10.1016/j.bmcl.2005.11.050 BindingDB Entry DOI: 10.7270/Q2QR4VCH
Academy of Sciences of the Czech Republic					More data for this Ligand-Target Pair
Thymidine phosphorylase (Escherichia coli)	BDBM20042 (5-chloro-6-(pyrrolidin-1-yl)-1,3-diazinane-2,4-dio...) Show SMILES Clc1c([nH]c(=O)[nH]c1=O)N1CCCC1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
Academy of Sciences of the Czech Republic					Assay Description The enzyme reaction was started by the addition of enzyme to the reaction mixture containing substrate and test compounds. The reaction was stopped b...				Bioorg Med Chem Lett 16: 1335-7 (2006) Article DOI: 10.1016/j.bmcl.2005.11.050 BindingDB Entry DOI: 10.7270/Q2QR4VCH
Academy of Sciences of the Czech Republic					More data for this Ligand-Target Pair
Thymidine phosphorylase (Homo sapiens (Human))	BDBM20040 (5-bromo-6-[4-(2-hydroxyethyl)piperidin-1-yl]-1,3-d...) Show SMILES OCCC1CCN(CC1)c1[nH]c(=O)[nH]c(=O)c1Br Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.00E+3	n/a	n/a	n/a	n/a	6.4	37
Academy of Sciences of the Czech Republic					Assay Description The enzyme reaction was started by the addition of enzyme to the reaction mixture containing substrate and test compounds. The reaction was stopped b...				Bioorg Med Chem Lett 16: 1335-7 (2006) Article DOI: 10.1016/j.bmcl.2005.11.050 BindingDB Entry DOI: 10.7270/Q2QR4VCH
Academy of Sciences of the Czech Republic					More data for this Ligand-Target Pair
Thymidine phosphorylase (Homo sapiens (Human))	BDBM20032 (5-bromo-6-(pyrrolidin-1-yl)-1,3-diazinane-2,4-dion...) Show SMILES Brc1c([nH]c(=O)[nH]c1=O)N1CCCC1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.10E+3	n/a	n/a	n/a	n/a	6.4	37
Academy of Sciences of the Czech Republic					Assay Description The enzyme reaction was started by the addition of enzyme to the reaction mixture containing substrate and test compounds. The reaction was stopped b...				Bioorg Med Chem Lett 16: 1335-7 (2006) Article DOI: 10.1016/j.bmcl.2005.11.050 BindingDB Entry DOI: 10.7270/Q2QR4VCH
Academy of Sciences of the Czech Republic					More data for this Ligand-Target Pair
Thymidine phosphorylase (Homo sapiens (Human))	BDBM20038 (5-bromo-6-[3-(hydroxymethyl)piperidin-1-yl]-1,3-di...) Show SMILES OCC1CCCN(C1)c1[nH]c(=O)[nH]c(=O)c1Br Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.20E+3	n/a	n/a	n/a	n/a	6.4	37
Academy of Sciences of the Czech Republic					Assay Description The enzyme reaction was started by the addition of enzyme to the reaction mixture containing substrate and test compounds. The reaction was stopped b...				Bioorg Med Chem Lett 16: 1335-7 (2006) Article DOI: 10.1016/j.bmcl.2005.11.050 BindingDB Entry DOI: 10.7270/Q2QR4VCH
Academy of Sciences of the Czech Republic					More data for this Ligand-Target Pair
Thymidine phosphorylase (Escherichia coli)	BDBM20032 (5-bromo-6-(pyrrolidin-1-yl)-1,3-diazinane-2,4-dion...) Show SMILES Brc1c([nH]c(=O)[nH]c1=O)N1CCCC1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
Academy of Sciences of the Czech Republic					Assay Description The enzyme reaction was started by the addition of enzyme to the reaction mixture containing substrate and test compounds. The reaction was stopped b...				Bioorg Med Chem Lett 16: 1335-7 (2006) Article DOI: 10.1016/j.bmcl.2005.11.050 BindingDB Entry DOI: 10.7270/Q2QR4VCH
Academy of Sciences of the Czech Republic					More data for this Ligand-Target Pair
Thymidine phosphorylase (Escherichia coli)	BDBM20048 (5-chloro-6-[3-(hydroxymethyl)piperidin-1-yl]-1,3-d...) Show SMILES OCC1CCCN(C1)c1[nH]c(=O)[nH]c(=O)c1Cl Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
Academy of Sciences of the Czech Republic					Assay Description The enzyme reaction was started by the addition of enzyme to the reaction mixture containing substrate and test compounds. The reaction was stopped b...				Bioorg Med Chem Lett 16: 1335-7 (2006) Article DOI: 10.1016/j.bmcl.2005.11.050 BindingDB Entry DOI: 10.7270/Q2QR4VCH
Academy of Sciences of the Czech Republic					More data for this Ligand-Target Pair
Thymidine phosphorylase (Escherichia coli)	BDBM20050 (5-chloro-6-[4-(2-hydroxyethyl)piperidin-1-yl]-1,3-...) Show SMILES OCCC1CCN(CC1)c1[nH]c(=O)[nH]c(=O)c1Cl Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Academy of Sciences of the Czech Republic					Assay Description The enzyme reaction was started by the addition of enzyme to the reaction mixture containing substrate and test compounds. The reaction was stopped b...				Bioorg Med Chem Lett 16: 1335-7 (2006) Article DOI: 10.1016/j.bmcl.2005.11.050 BindingDB Entry DOI: 10.7270/Q2QR4VCH
Academy of Sciences of the Czech Republic					More data for this Ligand-Target Pair
Thymidine phosphorylase (Escherichia coli)	BDBM20039 (5-bromo-6-[4-(hydroxymethyl)piperidin-1-yl]-1,3-di...) Show SMILES OCC1CCN(CC1)c1[nH]c(=O)[nH]c(=O)c1Br Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Academy of Sciences of the Czech Republic					Assay Description The enzyme reaction was started by the addition of enzyme to the reaction mixture containing substrate and test compounds. The reaction was stopped b...				Bioorg Med Chem Lett 16: 1335-7 (2006) Article DOI: 10.1016/j.bmcl.2005.11.050 BindingDB Entry DOI: 10.7270/Q2QR4VCH
Academy of Sciences of the Czech Republic					More data for this Ligand-Target Pair
Thymidine phosphorylase (Escherichia coli)	BDBM20040 (5-bromo-6-[4-(2-hydroxyethyl)piperidin-1-yl]-1,3-d...) Show SMILES OCCC1CCN(CC1)c1[nH]c(=O)[nH]c(=O)c1Br Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
Academy of Sciences of the Czech Republic					Assay Description The enzyme reaction was started by the addition of enzyme to the reaction mixture containing substrate and test compounds. The reaction was stopped b...				Bioorg Med Chem Lett 16: 1335-7 (2006) Article DOI: 10.1016/j.bmcl.2005.11.050 BindingDB Entry DOI: 10.7270/Q2QR4VCH
Academy of Sciences of the Czech Republic					More data for this Ligand-Target Pair
Thymidine phosphorylase (Escherichia coli)	BDBM20038 (5-bromo-6-[3-(hydroxymethyl)piperidin-1-yl]-1,3-di...) Show SMILES OCC1CCCN(C1)c1[nH]c(=O)[nH]c(=O)c1Br Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Academy of Sciences of the Czech Republic					Assay Description The enzyme reaction was started by the addition of enzyme to the reaction mixture containing substrate and test compounds. The reaction was stopped b...				Bioorg Med Chem Lett 16: 1335-7 (2006) Article DOI: 10.1016/j.bmcl.2005.11.050 BindingDB Entry DOI: 10.7270/Q2QR4VCH
Academy of Sciences of the Czech Republic					More data for this Ligand-Target Pair
Thymidine phosphorylase (Escherichia coli)	BDBM20037 (5-bromo-6-[2-(hydroxymethyl)piperidin-1-yl]-1,3-di...) Show SMILES OCC1CCCCN1c1[nH]c(=O)[nH]c(=O)c1Br Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Academy of Sciences of the Czech Republic					Assay Description The enzyme reaction was started by the addition of enzyme to the reaction mixture containing substrate and test compounds. The reaction was stopped b...				Bioorg Med Chem Lett 16: 1335-7 (2006) Article DOI: 10.1016/j.bmcl.2005.11.050 BindingDB Entry DOI: 10.7270/Q2QR4VCH
Academy of Sciences of the Czech Republic					More data for this Ligand-Target Pair
Thymidine phosphorylase (Homo sapiens (Human))	BDBM20033 (6-(azetidin-1-yl)-5-bromo-1,3-diazinane-2,4-dione ...) Show SMILES Brc1c([nH]c(=O)[nH]c1=O)N1CCC1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.80E+3	n/a	n/a	n/a	n/a	6.4	37
Academy of Sciences of the Czech Republic					Assay Description The enzyme reaction was started by the addition of enzyme to the reaction mixture containing substrate and test compounds. The reaction was stopped b...				Bioorg Med Chem Lett 16: 1335-7 (2006) Article DOI: 10.1016/j.bmcl.2005.11.050 BindingDB Entry DOI: 10.7270/Q2QR4VCH
Academy of Sciences of the Czech Republic					More data for this Ligand-Target Pair
Thymidine phosphorylase (Homo sapiens (Human))	BDBM20046 (5-chloro-6-(cyclopropylamino)-1,3-diazinane-2,4-di...) Show SMILES Clc1c(NC2CC2)[nH]c(=O)[nH]c1=O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7.00E+3	n/a	n/a	n/a	n/a	6.4	37
Academy of Sciences of the Czech Republic					Assay Description The enzyme reaction was started by the addition of enzyme to the reaction mixture containing substrate and test compounds. The reaction was stopped b...				Bioorg Med Chem Lett 16: 1335-7 (2006) Article DOI: 10.1016/j.bmcl.2005.11.050 BindingDB Entry DOI: 10.7270/Q2QR4VCH
Academy of Sciences of the Czech Republic					More data for this Ligand-Target Pair
Thymidine phosphorylase (Homo sapiens (Human))	BDBM20037 (5-bromo-6-[2-(hydroxymethyl)piperidin-1-yl]-1,3-di...) Show SMILES OCC1CCCCN1c1[nH]c(=O)[nH]c(=O)c1Br Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7.00E+3	n/a	n/a	n/a	n/a	6.4	37
Academy of Sciences of the Czech Republic					Assay Description The enzyme reaction was started by the addition of enzyme to the reaction mixture containing substrate and test compounds. The reaction was stopped b...				Bioorg Med Chem Lett 16: 1335-7 (2006) Article DOI: 10.1016/j.bmcl.2005.11.050 BindingDB Entry DOI: 10.7270/Q2QR4VCH
Academy of Sciences of the Czech Republic					More data for this Ligand-Target Pair
Thymidine phosphorylase (Homo sapiens (Human))	BDBM20036 (5-bromo-6-(cyclopropylamino)-1,3-diazinane-2,4-dio...) Show SMILES Brc1c(NC2CC2)[nH]c(=O)[nH]c1=O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7.20E+3	n/a	n/a	n/a	n/a	6.4	37
Academy of Sciences of the Czech Republic					Assay Description The enzyme reaction was started by the addition of enzyme to the reaction mixture containing substrate and test compounds. The reaction was stopped b...				Bioorg Med Chem Lett 16: 1335-7 (2006) Article DOI: 10.1016/j.bmcl.2005.11.050 BindingDB Entry DOI: 10.7270/Q2QR4VCH
Academy of Sciences of the Czech Republic					More data for this Ligand-Target Pair
Thymidine phosphorylase (Homo sapiens (Human))	BDBM20053 (5-chloro-6-[4-(5-chloro-2,6-dioxo-1,2,3,6-tetrahyd...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	7.20E+3	n/a	n/a	n/a	n/a	6.4	37
Academy of Sciences of the Czech Republic					Assay Description The enzyme reaction was started by the addition of enzyme to the reaction mixture containing substrate and test compounds. The reaction was stopped b...				Bioorg Med Chem Lett 16: 1335-7 (2006) Article DOI: 10.1016/j.bmcl.2005.11.050 BindingDB Entry DOI: 10.7270/Q2QR4VCH
Academy of Sciences of the Czech Republic					More data for this Ligand-Target Pair
Thymidine phosphorylase (Homo sapiens (Human))	BDBM20035 (5-bromo-6-(morpholin-4-yl)-1,3-diazinane-2,4-dione...) Show SMILES Brc1c([nH]c(=O)[nH]c1=O)N1CCOCC1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	7.20E+3	n/a	n/a	n/a	n/a	6.4	37
Academy of Sciences of the Czech Republic					Assay Description The enzyme reaction was started by the addition of enzyme to the reaction mixture containing substrate and test compounds. The reaction was stopped b...				Bioorg Med Chem Lett 16: 1335-7 (2006) Article DOI: 10.1016/j.bmcl.2005.11.050 BindingDB Entry DOI: 10.7270/Q2QR4VCH
Academy of Sciences of the Czech Republic					More data for this Ligand-Target Pair
Thymidine phosphorylase (Escherichia coli)	BDBM20041 (5-chloro-6-(piperidin-1-yl)-1,3-diazinane-2,4-dion...) Show SMILES Clc1c([nH]c(=O)[nH]c1=O)N1CCCCC1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
Academy of Sciences of the Czech Republic					Assay Description The enzyme reaction was started by the addition of enzyme to the reaction mixture containing substrate and test compounds. The reaction was stopped b...				Bioorg Med Chem Lett 16: 1335-7 (2006) Article DOI: 10.1016/j.bmcl.2005.11.050 BindingDB Entry DOI: 10.7270/Q2QR4VCH
Academy of Sciences of the Czech Republic					More data for this Ligand-Target Pair
Thymidine phosphorylase (Escherichia coli)	BDBM20049 (5-chloro-6-[4-(hydroxymethyl)piperidin-1-yl]-1,3-d...) Show SMILES OCC1CCN(CC1)c1[nH]c(=O)[nH]c(=O)c1Cl Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Academy of Sciences of the Czech Republic					Assay Description The enzyme reaction was started by the addition of enzyme to the reaction mixture containing substrate and test compounds. The reaction was stopped b...				Bioorg Med Chem Lett 16: 1335-7 (2006) Article DOI: 10.1016/j.bmcl.2005.11.050 BindingDB Entry DOI: 10.7270/Q2QR4VCH
Academy of Sciences of the Czech Republic					More data for this Ligand-Target Pair
Thymidine phosphorylase (Homo sapiens (Human))	BDBM20050 (5-chloro-6-[4-(2-hydroxyethyl)piperidin-1-yl]-1,3-...) Show SMILES OCCC1CCN(CC1)c1[nH]c(=O)[nH]c(=O)c1Cl Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7.50E+3	n/a	n/a	n/a	n/a	6.4	37
Academy of Sciences of the Czech Republic					Assay Description The enzyme reaction was started by the addition of enzyme to the reaction mixture containing substrate and test compounds. The reaction was stopped b...				Bioorg Med Chem Lett 16: 1335-7 (2006) Article DOI: 10.1016/j.bmcl.2005.11.050 BindingDB Entry DOI: 10.7270/Q2QR4VCH
Academy of Sciences of the Czech Republic					More data for this Ligand-Target Pair
Thymidine phosphorylase (Homo sapiens (Human))	BDBM20039 (5-bromo-6-[4-(hydroxymethyl)piperidin-1-yl]-1,3-di...) Show SMILES OCC1CCN(CC1)c1[nH]c(=O)[nH]c(=O)c1Br Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7.50E+3	n/a	n/a	n/a	n/a	6.4	37
Academy of Sciences of the Czech Republic					Assay Description The enzyme reaction was started by the addition of enzyme to the reaction mixture containing substrate and test compounds. The reaction was stopped b...				Bioorg Med Chem Lett 16: 1335-7 (2006) Article DOI: 10.1016/j.bmcl.2005.11.050 BindingDB Entry DOI: 10.7270/Q2QR4VCH
Academy of Sciences of the Czech Republic					More data for this Ligand-Target Pair
Thymidine phosphorylase (Homo sapiens (Human))	BDBM20047 (5-chloro-6-[2-(hydroxymethyl)piperidin-1-yl]-1,3-d...) Show SMILES OCC1CCCCN1c1[nH]c(=O)[nH]c(=O)c1Cl Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	8.00E+3	n/a	n/a	n/a	n/a	6.4	37
Academy of Sciences of the Czech Republic					Assay Description The enzyme reaction was started by the addition of enzyme to the reaction mixture containing substrate and test compounds. The reaction was stopped b...				Bioorg Med Chem Lett 16: 1335-7 (2006) Article DOI: 10.1016/j.bmcl.2005.11.050 BindingDB Entry DOI: 10.7270/Q2QR4VCH
Academy of Sciences of the Czech Republic					More data for this Ligand-Target Pair
Thymidine phosphorylase (Homo sapiens (Human))	BDBM20043 (6-(azetidin-1-yl)-5-chloro-1,3-diazinane-2,4-dione...) Show SMILES Clc1c([nH]c(=O)[nH]c1=O)N1CCC1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	8.00E+3	n/a	n/a	n/a	n/a	6.4	37
Academy of Sciences of the Czech Republic					Assay Description The enzyme reaction was started by the addition of enzyme to the reaction mixture containing substrate and test compounds. The reaction was stopped b...				Bioorg Med Chem Lett 16: 1335-7 (2006) Article DOI: 10.1016/j.bmcl.2005.11.050 BindingDB Entry DOI: 10.7270/Q2QR4VCH
Academy of Sciences of the Czech Republic					More data for this Ligand-Target Pair
Thymidine phosphorylase (Homo sapiens (Human))	BDBM20031 (5-bromo-6-(piperidin-1-yl)-1,3-diazinane-2,4-dione...) Show SMILES Brc1c([nH]c(=O)[nH]c1=O)N1CCCCC1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	8.20E+3	n/a	n/a	n/a	n/a	6.4	37
Academy of Sciences of the Czech Republic					Assay Description The enzyme reaction was started by the addition of enzyme to the reaction mixture containing substrate and test compounds. The reaction was stopped b...				Bioorg Med Chem Lett 16: 1335-7 (2006) Article DOI: 10.1016/j.bmcl.2005.11.050 BindingDB Entry DOI: 10.7270/Q2QR4VCH
Academy of Sciences of the Czech Republic					More data for this Ligand-Target Pair
Thymidine phosphorylase (Homo sapiens (Human))	BDBM20045 (5-chloro-6-(morpholin-4-yl)-1,3-diazinane-2,4-dion...) Show SMILES Clc1c([nH]c(=O)[nH]c1=O)N1CCOCC1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	8.30E+3	n/a	n/a	n/a	n/a	6.4	37
Academy of Sciences of the Czech Republic					Assay Description The enzyme reaction was started by the addition of enzyme to the reaction mixture containing substrate and test compounds. The reaction was stopped b...				Bioorg Med Chem Lett 16: 1335-7 (2006) Article DOI: 10.1016/j.bmcl.2005.11.050 BindingDB Entry DOI: 10.7270/Q2QR4VCH
Academy of Sciences of the Czech Republic					More data for this Ligand-Target Pair
Thymidine phosphorylase (Homo sapiens (Human))	BDBM20049 (5-chloro-6-[4-(hydroxymethyl)piperidin-1-yl]-1,3-d...) Show SMILES OCC1CCN(CC1)c1[nH]c(=O)[nH]c(=O)c1Cl Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	8.50E+3	n/a	n/a	n/a	n/a	6.4	37
Academy of Sciences of the Czech Republic					Assay Description The enzyme reaction was started by the addition of enzyme to the reaction mixture containing substrate and test compounds. The reaction was stopped b...				Bioorg Med Chem Lett 16: 1335-7 (2006) Article DOI: 10.1016/j.bmcl.2005.11.050 BindingDB Entry DOI: 10.7270/Q2QR4VCH
Academy of Sciences of the Czech Republic					More data for this Ligand-Target Pair
Thymidine phosphorylase (Escherichia coli)	BDBM20053 (5-chloro-6-[4-(5-chloro-2,6-dioxo-1,2,3,6-tetrahyd...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	8.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
Academy of Sciences of the Czech Republic					Assay Description The enzyme reaction was started by the addition of enzyme to the reaction mixture containing substrate and test compounds. The reaction was stopped b...				Bioorg Med Chem Lett 16: 1335-7 (2006) Article DOI: 10.1016/j.bmcl.2005.11.050 BindingDB Entry DOI: 10.7270/Q2QR4VCH
Academy of Sciences of the Czech Republic					More data for this Ligand-Target Pair
Thymidine phosphorylase (Homo sapiens (Human))	BDBM20048 (5-chloro-6-[3-(hydroxymethyl)piperidin-1-yl]-1,3-d...) Show SMILES OCC1CCCN(C1)c1[nH]c(=O)[nH]c(=O)c1Cl Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	9.00E+3	n/a	n/a	n/a	n/a	6.4	37
Academy of Sciences of the Czech Republic					Assay Description The enzyme reaction was started by the addition of enzyme to the reaction mixture containing substrate and test compounds. The reaction was stopped b...				Bioorg Med Chem Lett 16: 1335-7 (2006) Article DOI: 10.1016/j.bmcl.2005.11.050 BindingDB Entry DOI: 10.7270/Q2QR4VCH
Academy of Sciences of the Czech Republic					More data for this Ligand-Target Pair
Thymidine phosphorylase (Escherichia coli)	BDBM20031 (5-bromo-6-(piperidin-1-yl)-1,3-diazinane-2,4-dione...) Show SMILES Brc1c([nH]c(=O)[nH]c1=O)N1CCCCC1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	9.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
Academy of Sciences of the Czech Republic					Assay Description The enzyme reaction was started by the addition of enzyme to the reaction mixture containing substrate and test compounds. The reaction was stopped b...				Bioorg Med Chem Lett 16: 1335-7 (2006) Article DOI: 10.1016/j.bmcl.2005.11.050 BindingDB Entry DOI: 10.7270/Q2QR4VCH
Academy of Sciences of the Czech Republic					More data for this Ligand-Target Pair
Thymidine phosphorylase (Escherichia coli)	BDBM20044 (5-chloro-6-hydrazinyl-1,3-diazinane-2,4-dione \| ur...) Show SMILES NNc1[nH]c(=O)[nH]c(=O)c1Cl Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	9.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
Academy of Sciences of the Czech Republic					Assay Description The enzyme reaction was started by the addition of enzyme to the reaction mixture containing substrate and test compounds. The reaction was stopped b...				Bioorg Med Chem Lett 16: 1335-7 (2006) Article DOI: 10.1016/j.bmcl.2005.11.050 BindingDB Entry DOI: 10.7270/Q2QR4VCH
Academy of Sciences of the Czech Republic					More data for this Ligand-Target Pair
Thymidine phosphorylase (Homo sapiens (Human))	BDBM20042 (5-chloro-6-(pyrrolidin-1-yl)-1,3-diazinane-2,4-dio...) Show SMILES Clc1c([nH]c(=O)[nH]c1=O)N1CCCC1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	9.50E+3	n/a	n/a	n/a	n/a	6.4	37
Academy of Sciences of the Czech Republic					Assay Description The enzyme reaction was started by the addition of enzyme to the reaction mixture containing substrate and test compounds. The reaction was stopped b...				Bioorg Med Chem Lett 16: 1335-7 (2006) Article DOI: 10.1016/j.bmcl.2005.11.050 BindingDB Entry DOI: 10.7270/Q2QR4VCH
Academy of Sciences of the Czech Republic					More data for this Ligand-Target Pair
Thymidine phosphorylase (Escherichia coli)	BDBM20046 (5-chloro-6-(cyclopropylamino)-1,3-diazinane-2,4-di...) Show SMILES Clc1c(NC2CC2)[nH]c(=O)[nH]c1=O Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.01E+4	n/a	n/a	n/a	n/a	n/a	n/a
Academy of Sciences of the Czech Republic					Assay Description The enzyme reaction was started by the addition of enzyme to the reaction mixture containing substrate and test compounds. The reaction was stopped b...				Bioorg Med Chem Lett 16: 1335-7 (2006) Article DOI: 10.1016/j.bmcl.2005.11.050 BindingDB Entry DOI: 10.7270/Q2QR4VCH
Academy of Sciences of the Czech Republic					More data for this Ligand-Target Pair
Thymidine phosphorylase (Homo sapiens (Human))	BDBM20044 (5-chloro-6-hydrazinyl-1,3-diazinane-2,4-dione \| ur...) Show SMILES NNc1[nH]c(=O)[nH]c(=O)c1Cl Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.02E+4	n/a	n/a	n/a	n/a	6.4	37
Academy of Sciences of the Czech Republic					Assay Description The enzyme reaction was started by the addition of enzyme to the reaction mixture containing substrate and test compounds. The reaction was stopped b...				Bioorg Med Chem Lett 16: 1335-7 (2006) Article DOI: 10.1016/j.bmcl.2005.11.050 BindingDB Entry DOI: 10.7270/Q2QR4VCH
Academy of Sciences of the Czech Republic					More data for this Ligand-Target Pair
Thymidine phosphorylase (Escherichia coli)	BDBM20045 (5-chloro-6-(morpholin-4-yl)-1,3-diazinane-2,4-dion...) Show SMILES Clc1c([nH]c(=O)[nH]c1=O)N1CCOCC1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.04E+4	n/a	n/a	n/a	n/a	n/a	n/a
Academy of Sciences of the Czech Republic					Assay Description The enzyme reaction was started by the addition of enzyme to the reaction mixture containing substrate and test compounds. The reaction was stopped b...				Bioorg Med Chem Lett 16: 1335-7 (2006) Article DOI: 10.1016/j.bmcl.2005.11.050 BindingDB Entry DOI: 10.7270/Q2QR4VCH
Academy of Sciences of the Czech Republic					More data for this Ligand-Target Pair
Thymidine phosphorylase (Homo sapiens (Human))	BDBM20030 (6-amino-5-chloro-1,3-diazinane-2,4-dione \| 6-amino...) Show SMILES Nc1[nH]c(=O)[nH]c(=O)c1Cl Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	1.16E+4	n/a	n/a	n/a	n/a	6.4	37
Academy of Sciences of the Czech Republic					Assay Description The enzyme reaction was started by the addition of enzyme to the reaction mixture containing substrate and test compounds. The reaction was stopped b...				Bioorg Med Chem Lett 16: 1335-7 (2006) Article DOI: 10.1016/j.bmcl.2005.11.050 BindingDB Entry DOI: 10.7270/Q2QR4VCH
Academy of Sciences of the Czech Republic					More data for this Ligand-Target Pair
Thymidine phosphorylase (Escherichia coli)	BDBM20035 (5-bromo-6-(morpholin-4-yl)-1,3-diazinane-2,4-dione...) Show SMILES Brc1c([nH]c(=O)[nH]c1=O)N1CCOCC1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.16E+4	n/a	n/a	n/a	n/a	n/a	n/a
Academy of Sciences of the Czech Republic					Assay Description The enzyme reaction was started by the addition of enzyme to the reaction mixture containing substrate and test compounds. The reaction was stopped b...				Bioorg Med Chem Lett 16: 1335-7 (2006) Article DOI: 10.1016/j.bmcl.2005.11.050 BindingDB Entry DOI: 10.7270/Q2QR4VCH
Academy of Sciences of the Czech Republic					More data for this Ligand-Target Pair
Thymidine phosphorylase (Escherichia coli)	BDBM20043 (6-(azetidin-1-yl)-5-chloro-1,3-diazinane-2,4-dione...) Show SMILES Clc1c([nH]c(=O)[nH]c1=O)N1CCC1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.40E+4	n/a	n/a	n/a	n/a	n/a	n/a
Academy of Sciences of the Czech Republic					Assay Description The enzyme reaction was started by the addition of enzyme to the reaction mixture containing substrate and test compounds. The reaction was stopped b...				Bioorg Med Chem Lett 16: 1335-7 (2006) Article DOI: 10.1016/j.bmcl.2005.11.050 BindingDB Entry DOI: 10.7270/Q2QR4VCH
Academy of Sciences of the Czech Republic					More data for this Ligand-Target Pair
Thymidine phosphorylase (Homo sapiens (Human))	BDBM20041 (5-chloro-6-(piperidin-1-yl)-1,3-diazinane-2,4-dion...) Show SMILES Clc1c([nH]c(=O)[nH]c1=O)N1CCCCC1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.57E+4	n/a	n/a	n/a	n/a	6.4	37
Academy of Sciences of the Czech Republic					Assay Description The enzyme reaction was started by the addition of enzyme to the reaction mixture containing substrate and test compounds. The reaction was stopped b...				Bioorg Med Chem Lett 16: 1335-7 (2006) Article DOI: 10.1016/j.bmcl.2005.11.050 BindingDB Entry DOI: 10.7270/Q2QR4VCH
Academy of Sciences of the Czech Republic					More data for this Ligand-Target Pair

* indicates data uncertainty>20%