| Reaction Details |
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 | Report a problem with these data |
| Target | Thymidine phosphorylase |
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| Ligand | BDBM20048 |
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| Substrate/Competitor | BDBM1 |
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| Meas. Tech. | Enzyme Inhibition Assay |
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| IC50 | 5400±n/a nM |
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| Citation |  Nencka, R; Votruba, I; Hrebabecký, H; Tloust'ová, E; Horská, K; Masojídková, M; Holý, A Design and synthesis of novel 5,6-disubstituted uracil derivatives as potent inhibitors of thymidine phosphorylase. Bioorg Med Chem Lett16:1335-7 (2006) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Thymidine phosphorylase |
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| Name: | Thymidine phosphorylase |
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| Synonyms: | TYPH_ECOLI | TdRPase | Thymidine Phosphorylase (TP) | deoA | tpp | ttg |
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| Type: | Enzyme |
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| Mol. Mass.: | 47198.54 |
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| Organism: | Escherichia coli |
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| Description: | n/a |
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| Residue: | 440 |
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| Sequence: | MFLAQEIIRKKRDGHALSDEEIRFFINGIRDNTISEGQIAALAMTIFFHDMTMPERVSLT
MAMRDSGTVLDWKSLHLNGPIVDKHSTGGVGDVTSLMLGPMVAACGGYIPMISGRGLGHT
GGTLDKLESIPGFDIFPDDNRFREIIKDVGVAIIGQTSSLAPADKRFYATRDITATVDSI
PLITASILAKKLAEGLDALVMDVKVGSGAFMPTYELSEALAEAIVGVANGAGVRTTALLT
DMNQVLASSAGNAVEVREAVQFLTGEYRNPRLFDVTMALCVEMLISGKLAKDDAEARAKL
QAVLDNGKAAEVFGRMVAAQKGPTDFVENYAKYLPTAMLTKAVYADTEGFVSEMDTRALG
MAVVAMGGGRRQASDTIDYSVGFTDMARLGDQVDGQRPLAVIHAKDENNWQEAAKAVKAA
IKLADKAPESTPTVYRRISE
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| BDBM20048 |
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| BDBM1 |
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| Name | BDBM20048 |
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| Synonyms: | 5-chloro-6-[3-(hydroxymethyl)piperidin-1-yl]-1,3-diazinane-2,4-dione | uracil, 18 |
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| Type | Small organic molecule |
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| Emp. Form. | C10H14ClN3O3 |
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| Mol. Mass. | 259.689 |
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| SMILES | OCC1CCCN(C1)c1[nH]c(=O)[nH]c(=O)c1Cl |
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| Structure | 
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