Found 46 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Receptor-type tyrosine-protein kinase FLT3
(Homo sapiens (Human)) | BDBM50185111
(2-(3,4-dimethoxybenzamido)-5,6-dihydro-4H-cyclopen...)Show InChI InChI=1S/C17H18N2O4S/c1-22-11-7-6-9(8-12(11)23-2)16(21)19-17-14(15(18)20)10-4-3-5-13(10)24-17/h6-8H,3-5H2,1-2H3,(H2,18,20)(H,19,21) | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
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CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 27 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of FLT3 |
Bioorg Med Chem Lett 16: 3282-6 (2006)
Article DOI: 10.1016/j.bmcl.2006.03.032
BindingDB Entry DOI: 10.7270/Q2R49QCV |
More data for this
Ligand-Target Pair | |
Receptor-type tyrosine-protein kinase FLT3
(Homo sapiens (Human)) | BDBM50185084
(2-(3,4-dimethoxybenzamido)-4,5,6,7-tetrahydrobenzo...)Show InChI InChI=1S/C18H20N2O4S/c1-23-12-8-7-10(9-13(12)24-2)17(22)20-18-15(16(19)21)11-5-3-4-6-14(11)25-18/h7-9H,3-6H2,1-2H3,(H2,19,21)(H,20,22) | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
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CHEMBL
MCE
PC cid
PC sid
UniChem
Patents
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| Article
PubMed
| n/a | n/a | 42 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of FLT3 |
Bioorg Med Chem Lett 16: 3282-6 (2006)
Article DOI: 10.1016/j.bmcl.2006.03.032
BindingDB Entry DOI: 10.7270/Q2R49QCV |
More data for this
Ligand-Target Pair | |
Receptor-type tyrosine-protein kinase FLT3
(Homo sapiens (Human)) | BDBM50185092
(2-(4-methylbenzamido)-4,5,6,7-tetrahydrobenzo[b]th...)Show InChI InChI=1S/C17H18N2O2S/c1-10-6-8-11(9-7-10)16(21)19-17-14(15(18)20)12-4-2-3-5-13(12)22-17/h6-9H,2-5H2,1H3,(H2,18,20)(H,19,21) | PDB
NCI pathway
Reactome pathway
KEGG
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CHEMBL
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PC sid
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PubMed
| n/a | n/a | 52 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of FLT3 |
Bioorg Med Chem Lett 16: 3282-6 (2006)
Article DOI: 10.1016/j.bmcl.2006.03.032
BindingDB Entry DOI: 10.7270/Q2R49QCV |
More data for this
Ligand-Target Pair | |
Receptor-type tyrosine-protein kinase FLT3
(Homo sapiens (Human)) | BDBM50185113
(2-(3-methoxybenzamido)-4,5,6,7-tetrahydrobenzo[b]t...)Show InChI InChI=1S/C17H18N2O3S/c1-22-11-6-4-5-10(9-11)16(21)19-17-14(15(18)20)12-7-2-3-8-13(12)23-17/h4-6,9H,2-3,7-8H2,1H3,(H2,18,20)(H,19,21) | PDB
NCI pathway
Reactome pathway
KEGG
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CHEMBL
PC cid
PC sid
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PubMed
| n/a | n/a | 110 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of FLT3 |
Bioorg Med Chem Lett 16: 3282-6 (2006)
Article DOI: 10.1016/j.bmcl.2006.03.032
BindingDB Entry DOI: 10.7270/Q2R49QCV |
More data for this
Ligand-Target Pair | |
Receptor-type tyrosine-protein kinase FLT3
(Homo sapiens (Human)) | BDBM50185083
(CHEMBL380184 | N-(3-carbamoyl-4,5,6,7-tetrahydrobe...)Show InChI InChI=1S/C15H15N3O2S/c16-13(19)12-10-3-1-2-4-11(10)21-15(12)18-14(20)9-5-7-17-8-6-9/h5-8H,1-4H2,(H2,16,19)(H,18,20) | PDB
NCI pathway
Reactome pathway
KEGG
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CHEMBL
PC cid
PC sid
UniChem
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| Article
PubMed
| n/a | n/a | 110 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of FLT3 |
Bioorg Med Chem Lett 16: 3282-6 (2006)
Article DOI: 10.1016/j.bmcl.2006.03.032
BindingDB Entry DOI: 10.7270/Q2R49QCV |
More data for this
Ligand-Target Pair | |
Receptor-type tyrosine-protein kinase FLT3
(Homo sapiens (Human)) | BDBM50185104
(2-(4-methoxybenzamido)-4,5,6,7-tetrahydrobenzo[b]t...)Show InChI InChI=1S/C17H18N2O3S/c1-22-11-8-6-10(7-9-11)16(21)19-17-14(15(18)20)12-4-2-3-5-13(12)23-17/h6-9H,2-5H2,1H3,(H2,18,20)(H,19,21) | PDB
NCI pathway
Reactome pathway
KEGG
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CHEMBL
PC cid
PC sid
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PubMed
| n/a | n/a | 120 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of FLT3 |
Bioorg Med Chem Lett 16: 3282-6 (2006)
Article DOI: 10.1016/j.bmcl.2006.03.032
BindingDB Entry DOI: 10.7270/Q2R49QCV |
More data for this
Ligand-Target Pair | |
Receptor-type tyrosine-protein kinase FLT3
(Homo sapiens (Human)) | BDBM50185099
(2-(3-(3,4-dimethoxyphenyl)acrylamido)-4,5,6,7-tetr...)Show SMILES COc1ccc(\C=C\C(=O)Nc2sc3CCCCc3c2C(N)=O)cc1OC Show InChI InChI=1S/C20H22N2O4S/c1-25-14-9-7-12(11-15(14)26-2)8-10-17(23)22-20-18(19(21)24)13-5-3-4-6-16(13)27-20/h7-11H,3-6H2,1-2H3,(H2,21,24)(H,22,23)/b10-8+ | PDB
NCI pathway
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KEGG
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CHEMBL
PC cid
PC sid
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PubMed
| n/a | n/a | 130 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of FLT3 |
Bioorg Med Chem Lett 16: 3282-6 (2006)
Article DOI: 10.1016/j.bmcl.2006.03.032
BindingDB Entry DOI: 10.7270/Q2R49QCV |
More data for this
Ligand-Target Pair | |
Receptor-type tyrosine-protein kinase FLT3
(Homo sapiens (Human)) | BDBM50185080
(CHEMBL426687 | N-(3-carbamoyl-4,5,6,7-tetrahydrobe...)Show InChI InChI=1S/C17H16N2O4S/c18-15(20)14-10-3-1-2-4-13(10)24-17(14)19-16(21)9-5-6-11-12(7-9)23-8-22-11/h5-7H,1-4,8H2,(H2,18,20)(H,19,21) | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
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DrugBank
antibodypedia
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CHEMBL
PC cid
PC sid
UniChem
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PubMed
| n/a | n/a | 140 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of FLT3 |
Bioorg Med Chem Lett 16: 3282-6 (2006)
Article DOI: 10.1016/j.bmcl.2006.03.032
BindingDB Entry DOI: 10.7270/Q2R49QCV |
More data for this
Ligand-Target Pair | |
Receptor-type tyrosine-protein kinase FLT3
(Homo sapiens (Human)) | BDBM50185110
(2-(3-methylbenzamido)-4,5,6,7-tetrahydrobenzo[b]th...)Show InChI InChI=1S/C17H18N2O2S/c1-10-5-4-6-11(9-10)16(21)19-17-14(15(18)20)12-7-2-3-8-13(12)22-17/h4-6,9H,2-3,7-8H2,1H3,(H2,18,20)(H,19,21) | PDB
NCI pathway
Reactome pathway
KEGG
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B.MOAD
DrugBank
antibodypedia
GoogleScholar
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CHEMBL
PC cid
PC sid
UniChem
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| Article
PubMed
| n/a | n/a | 140 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of FLT3 |
Bioorg Med Chem Lett 16: 3282-6 (2006)
Article DOI: 10.1016/j.bmcl.2006.03.032
BindingDB Entry DOI: 10.7270/Q2R49QCV |
More data for this
Ligand-Target Pair | |
Receptor-type tyrosine-protein kinase FLT3
(Homo sapiens (Human)) | BDBM50185077
(2-(3,4-dimethoxybenzamido)-4,5-dimethylthiophene-3...)Show InChI InChI=1S/C16H18N2O4S/c1-8-9(2)23-16(13(8)14(17)19)18-15(20)10-5-6-11(21-3)12(7-10)22-4/h5-7H,1-4H3,(H2,17,19)(H,18,20) | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
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CHEMBL
PC cid
PC sid
UniChem
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PubMed
| n/a | n/a | 140 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of FLT3 |
Bioorg Med Chem Lett 16: 3282-6 (2006)
Article DOI: 10.1016/j.bmcl.2006.03.032
BindingDB Entry DOI: 10.7270/Q2R49QCV |
More data for this
Ligand-Target Pair | |
Receptor-type tyrosine-protein kinase FLT3
(Homo sapiens (Human)) | BDBM50185117
(CHEMBL210960 | N-(3-carbamoyl-4,5,6,7-tetrahydrobe...)Show InChI InChI=1S/C14H14N2O3S/c15-12(17)11-8-4-1-2-6-10(8)20-14(11)16-13(18)9-5-3-7-19-9/h3,5,7H,1-2,4,6H2,(H2,15,17)(H,16,18) | PDB
NCI pathway
Reactome pathway
KEGG
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antibodypedia
GoogleScholar
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CHEMBL
PC cid
PC sid
UniChem
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| Article
PubMed
| n/a | n/a | 170 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of FLT3 |
Bioorg Med Chem Lett 16: 3282-6 (2006)
Article DOI: 10.1016/j.bmcl.2006.03.032
BindingDB Entry DOI: 10.7270/Q2R49QCV |
More data for this
Ligand-Target Pair | |
Receptor-type tyrosine-protein kinase FLT3
(Homo sapiens (Human)) | BDBM50185093
(2-cinnamamido-4,5,6,7-tetrahydrobenzo[b]thiophene-...)Show InChI InChI=1S/C18H18N2O2S/c19-17(22)16-13-8-4-5-9-14(13)23-18(16)20-15(21)11-10-12-6-2-1-3-7-12/h1-3,6-7,10-11H,4-5,8-9H2,(H2,19,22)(H,20,21)/b11-10+ | PDB
NCI pathway
Reactome pathway
KEGG
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CHEMBL
PC cid
PC sid
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PubMed
| n/a | n/a | 250 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of FLT3 |
Bioorg Med Chem Lett 16: 3282-6 (2006)
Article DOI: 10.1016/j.bmcl.2006.03.032
BindingDB Entry DOI: 10.7270/Q2R49QCV |
More data for this
Ligand-Target Pair | |
Receptor-type tyrosine-protein kinase FLT3
(Homo sapiens (Human)) | BDBM50185079
(2-(3-(4-methoxyphenyl)acrylamido)-4,5,6,7-tetrahyd...)Show InChI InChI=1S/C19H20N2O3S/c1-24-13-9-6-12(7-10-13)8-11-16(22)21-19-17(18(20)23)14-4-2-3-5-15(14)25-19/h6-11H,2-5H2,1H3,(H2,20,23)(H,21,22)/b11-8+ | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
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antibodypedia
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CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 250 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of FLT3 |
Bioorg Med Chem Lett 16: 3282-6 (2006)
Article DOI: 10.1016/j.bmcl.2006.03.032
BindingDB Entry DOI: 10.7270/Q2R49QCV |
More data for this
Ligand-Target Pair | |
Receptor-type tyrosine-protein kinase FLT3
(Homo sapiens (Human)) | BDBM50185091
(2-(4-bromobenzamido)-4,5,6,7-tetrahydrobenzo[b]thi...)Show InChI InChI=1S/C16H15BrN2O2S/c17-10-7-5-9(6-8-10)15(21)19-16-13(14(18)20)11-3-1-2-4-12(11)22-16/h5-8H,1-4H2,(H2,18,20)(H,19,21) | PDB
NCI pathway
Reactome pathway
KEGG
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DrugBank
antibodypedia
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CHEMBL
PC cid
PC sid
UniChem
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| Article
PubMed
| n/a | n/a | 310 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of FLT3 |
Bioorg Med Chem Lett 16: 3282-6 (2006)
Article DOI: 10.1016/j.bmcl.2006.03.032
BindingDB Entry DOI: 10.7270/Q2R49QCV |
More data for this
Ligand-Target Pair | |
Receptor-type tyrosine-protein kinase FLT3
(Homo sapiens (Human)) | BDBM50185086
(2-(4-chlorobenzamido)-4,5,6,7-tetrahydrobenzo[b]th...)Show InChI InChI=1S/C16H15ClN2O2S/c17-10-7-5-9(6-8-10)15(21)19-16-13(14(18)20)11-3-1-2-4-12(11)22-16/h5-8H,1-4H2,(H2,18,20)(H,19,21) | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
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CHEMBL
PC cid
PC sid
UniChem
Patents
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| Article
PubMed
| n/a | n/a | 310 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of FLT3 |
Bioorg Med Chem Lett 16: 3282-6 (2006)
Article DOI: 10.1016/j.bmcl.2006.03.032
BindingDB Entry DOI: 10.7270/Q2R49QCV |
More data for this
Ligand-Target Pair | |
Receptor-type tyrosine-protein kinase FLT3
(Homo sapiens (Human)) | BDBM50185089
(2-benzamido-4,5,6,7-tetrahydrobenzo[b]thiophene-3-...)Show InChI InChI=1S/C16H16N2O2S/c17-14(19)13-11-8-4-5-9-12(11)21-16(13)18-15(20)10-6-2-1-3-7-10/h1-3,6-7H,4-5,8-9H2,(H2,17,19)(H,18,20) | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
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CHEMBL
PC cid
PC sid
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| Article
PubMed
| n/a | n/a | 360 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of FLT3 |
Bioorg Med Chem Lett 16: 3282-6 (2006)
Article DOI: 10.1016/j.bmcl.2006.03.032
BindingDB Entry DOI: 10.7270/Q2R49QCV |
More data for this
Ligand-Target Pair | |
Receptor-type tyrosine-protein kinase FLT3
(Homo sapiens (Human)) | BDBM50185075
((E)-2-(3-(4-isopropylphenyl)acrylamido)-4,5,6,7-te...)Show SMILES CC(C)c1ccc(\C=C\C(=O)Nc2sc3CCCCc3c2C(N)=O)cc1 Show InChI InChI=1S/C21H24N2O2S/c1-13(2)15-10-7-14(8-11-15)9-12-18(24)23-21-19(20(22)25)16-5-3-4-6-17(16)26-21/h7-13H,3-6H2,1-2H3,(H2,22,25)(H,23,24)/b12-9+ | PDB
NCI pathway
Reactome pathway
KEGG
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DrugBank
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CHEMBL
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PubMed
| n/a | n/a | 490 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of FLT3 |
Bioorg Med Chem Lett 16: 3282-6 (2006)
Article DOI: 10.1016/j.bmcl.2006.03.032
BindingDB Entry DOI: 10.7270/Q2R49QCV |
More data for this
Ligand-Target Pair | |
Receptor-type tyrosine-protein kinase FLT3
(Homo sapiens (Human)) | BDBM50185090
(2-(3,4-dimethylbenzamido)-4,5,6,7-tetrahydrobenzo[...)Show InChI InChI=1S/C18H20N2O2S/c1-10-7-8-12(9-11(10)2)17(22)20-18-15(16(19)21)13-5-3-4-6-14(13)23-18/h7-9H,3-6H2,1-2H3,(H2,19,21)(H,20,22) | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
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CHEMBL
PC cid
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PubMed
| n/a | n/a | 540 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of FLT3 |
Bioorg Med Chem Lett 16: 3282-6 (2006)
Article DOI: 10.1016/j.bmcl.2006.03.032
BindingDB Entry DOI: 10.7270/Q2R49QCV |
More data for this
Ligand-Target Pair | |
Receptor-type tyrosine-protein kinase FLT3
(Homo sapiens (Human)) | BDBM50185096
(2-(3-(furan-2-yl)acrylamido)-4,5,6,7-tetrahydroben...)Show InChI InChI=1S/C16H16N2O3S/c17-15(20)14-11-5-1-2-6-12(11)22-16(14)18-13(19)8-7-10-4-3-9-21-10/h3-4,7-9H,1-2,5-6H2,(H2,17,20)(H,18,19)/b8-7+ | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
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antibodypedia
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CHEMBL
PC cid
PC sid
UniChem
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| Article
PubMed
| n/a | n/a | 560 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of FLT3 |
Bioorg Med Chem Lett 16: 3282-6 (2006)
Article DOI: 10.1016/j.bmcl.2006.03.032
BindingDB Entry DOI: 10.7270/Q2R49QCV |
More data for this
Ligand-Target Pair | |
Receptor-type tyrosine-protein kinase FLT3
(Homo sapiens (Human)) | BDBM50185102
(2-(4-acetylbenzamido)-4,5,6,7-tetrahydrobenzo[b]th...)Show InChI InChI=1S/C18H18N2O3S/c1-10(21)11-6-8-12(9-7-11)17(23)20-18-15(16(19)22)13-4-2-3-5-14(13)24-18/h6-9H,2-5H2,1H3,(H2,19,22)(H,20,23) | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
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CHEMBL
PC cid
PC sid
UniChem
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| Article
PubMed
| n/a | n/a | 590 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of FLT3 |
Bioorg Med Chem Lett 16: 3282-6 (2006)
Article DOI: 10.1016/j.bmcl.2006.03.032
BindingDB Entry DOI: 10.7270/Q2R49QCV |
More data for this
Ligand-Target Pair | |
Receptor-type tyrosine-protein kinase FLT3
(Homo sapiens (Human)) | BDBM50185074
(2-(4-tert-butylbenzamido)-4,5,6,7-tetrahydrobenzo[...)Show SMILES CC(C)(C)c1ccc(cc1)C(=O)Nc1sc2CCCCc2c1C(N)=O Show InChI InChI=1S/C20H24N2O2S/c1-20(2,3)13-10-8-12(9-11-13)18(24)22-19-16(17(21)23)14-6-4-5-7-15(14)25-19/h8-11H,4-7H2,1-3H3,(H2,21,23)(H,22,24) | PDB
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| n/a | n/a | 630 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of FLT3 |
Bioorg Med Chem Lett 16: 3282-6 (2006)
Article DOI: 10.1016/j.bmcl.2006.03.032
BindingDB Entry DOI: 10.7270/Q2R49QCV |
More data for this
Ligand-Target Pair | |
Receptor-type tyrosine-protein kinase FLT3
(Homo sapiens (Human)) | BDBM50185109
(2-(3-chlorobenzamido)-4,5,6,7-tetrahydrobenzo[b]th...)Show InChI InChI=1S/C16H15ClN2O2S/c17-10-5-3-4-9(8-10)15(21)19-16-13(14(18)20)11-6-1-2-7-12(11)22-16/h3-5,8H,1-2,6-7H2,(H2,18,20)(H,19,21) | PDB
NCI pathway
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| n/a | n/a | 630 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of FLT3 |
Bioorg Med Chem Lett 16: 3282-6 (2006)
Article DOI: 10.1016/j.bmcl.2006.03.032
BindingDB Entry DOI: 10.7270/Q2R49QCV |
More data for this
Ligand-Target Pair | |
Receptor-type tyrosine-protein kinase FLT3
(Homo sapiens (Human)) | BDBM50185087
(CHEMBL210907 | N-(3-carbamoyl-4,5,6,7-tetrahydrobe...)Show InChI InChI=1S/C15H15N3O2S/c16-13(19)12-9-5-1-2-7-11(9)21-15(12)18-14(20)10-6-3-4-8-17-10/h3-4,6,8H,1-2,5,7H2,(H2,16,19)(H,18,20) | PDB
NCI pathway
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| n/a | n/a | 640 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of FLT3 |
Bioorg Med Chem Lett 16: 3282-6 (2006)
Article DOI: 10.1016/j.bmcl.2006.03.032
BindingDB Entry DOI: 10.7270/Q2R49QCV |
More data for this
Ligand-Target Pair | |
Receptor-type tyrosine-protein kinase FLT3
(Homo sapiens (Human)) | BDBM50185081
((E)-2-(3-(5-methylfuran-2-yl)acrylamido)-4,5,6,7-t...)Show InChI InChI=1S/C17H18N2O3S/c1-10-6-7-11(22-10)8-9-14(20)19-17-15(16(18)21)12-4-2-3-5-13(12)23-17/h6-9H,2-5H2,1H3,(H2,18,21)(H,19,20)/b9-8+ | PDB
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| n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of FLT3 |
Bioorg Med Chem Lett 16: 3282-6 (2006)
Article DOI: 10.1016/j.bmcl.2006.03.032
BindingDB Entry DOI: 10.7270/Q2R49QCV |
More data for this
Ligand-Target Pair | |
Receptor-type tyrosine-protein kinase FLT3
(Homo sapiens (Human)) | BDBM50185115
(CHEMBL209204 | N-(3-carbamoyl-4,5,6,7-tetrahydrobe...)Show InChI InChI=1S/C15H15N3O2S/c16-13(19)12-10-5-1-2-6-11(10)21-15(12)18-14(20)9-4-3-7-17-8-9/h3-4,7-8H,1-2,5-6H2,(H2,16,19)(H,18,20) | PDB
NCI pathway
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MCE
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| n/a | n/a | 1.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of FLT3 |
Bioorg Med Chem Lett 16: 3282-6 (2006)
Article DOI: 10.1016/j.bmcl.2006.03.032
BindingDB Entry DOI: 10.7270/Q2R49QCV |
More data for this
Ligand-Target Pair | |
Receptor-type tyrosine-protein kinase FLT3
(Homo sapiens (Human)) | BDBM50185119
(2-(cyclopropanecarboxamido)-4,5,6,7-tetrahydrobenz...)Show InChI InChI=1S/C13H16N2O2S/c14-11(16)10-8-3-1-2-4-9(8)18-13(10)15-12(17)7-5-6-7/h7H,1-6H2,(H2,14,16)(H,15,17) | PDB
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| n/a | n/a | 1.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of FLT3 |
Bioorg Med Chem Lett 16: 3282-6 (2006)
Article DOI: 10.1016/j.bmcl.2006.03.032
BindingDB Entry DOI: 10.7270/Q2R49QCV |
More data for this
Ligand-Target Pair | |
Receptor-type tyrosine-protein kinase FLT3
(Homo sapiens (Human)) | BDBM50185095
(2-(3,5-dimethoxybenzamido)-4,5,6,7-tetrahydrobenzo...)Show InChI InChI=1S/C18H20N2O4S/c1-23-11-7-10(8-12(9-11)24-2)17(22)20-18-15(16(19)21)13-5-3-4-6-14(13)25-18/h7-9H,3-6H2,1-2H3,(H2,19,21)(H,20,22) | PDB
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| n/a | n/a | 1.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of FLT3 |
Bioorg Med Chem Lett 16: 3282-6 (2006)
Article DOI: 10.1016/j.bmcl.2006.03.032
BindingDB Entry DOI: 10.7270/Q2R49QCV |
More data for this
Ligand-Target Pair | |
Receptor-type tyrosine-protein kinase FLT3
(Homo sapiens (Human)) | BDBM50185076
(2-acetamido-4,5,6,7-tetrahydrobenzo[b]thiophene-3-...)Show InChI InChI=1S/C11H14N2O2S/c1-6(14)13-11-9(10(12)15)7-4-2-3-5-8(7)16-11/h2-5H2,1H3,(H2,12,15)(H,13,14) | PDB
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| n/a | n/a | 2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of FLT3 |
Bioorg Med Chem Lett 16: 3282-6 (2006)
Article DOI: 10.1016/j.bmcl.2006.03.032
BindingDB Entry DOI: 10.7270/Q2R49QCV |
More data for this
Ligand-Target Pair | |
Receptor-type tyrosine-protein kinase FLT3
(Homo sapiens (Human)) | BDBM50185082
(2-(3,4-dimethoxybenzamido)thiophene-3-carboxamide ...)Show InChI InChI=1S/C14H14N2O4S/c1-19-10-4-3-8(7-11(10)20-2)13(18)16-14-9(12(15)17)5-6-21-14/h3-7H,1-2H3,(H2,15,17)(H,16,18) | PDB
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| n/a | n/a | 2.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of FLT3 |
Bioorg Med Chem Lett 16: 3282-6 (2006)
Article DOI: 10.1016/j.bmcl.2006.03.032
BindingDB Entry DOI: 10.7270/Q2R49QCV |
More data for this
Ligand-Target Pair | |
Receptor-type tyrosine-protein kinase FLT3
(Homo sapiens (Human)) | BDBM50185101
(2-propionamido-4,5,6,7-tetrahydrobenzo[b]thiophene...)Show InChI InChI=1S/C12H16N2O2S/c1-2-9(15)14-12-10(11(13)16)7-5-3-4-6-8(7)17-12/h2-6H2,1H3,(H2,13,16)(H,14,15) | PDB
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| n/a | n/a | 2.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of FLT3 |
Bioorg Med Chem Lett 16: 3282-6 (2006)
Article DOI: 10.1016/j.bmcl.2006.03.032
BindingDB Entry DOI: 10.7270/Q2R49QCV |
More data for this
Ligand-Target Pair | |
Receptor-type tyrosine-protein kinase FLT3
(Homo sapiens (Human)) | BDBM50185094
(2-(3-(4-methoxyphenyl)propanamido)-4,5,6,7-tetrahy...)Show InChI InChI=1S/C19H22N2O3S/c1-24-13-9-6-12(7-10-13)8-11-16(22)21-19-17(18(20)23)14-4-2-3-5-15(14)25-19/h6-7,9-10H,2-5,8,11H2,1H3,(H2,20,23)(H,21,22) | PDB
NCI pathway
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| n/a | n/a | 2.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of FLT3 |
Bioorg Med Chem Lett 16: 3282-6 (2006)
Article DOI: 10.1016/j.bmcl.2006.03.032
BindingDB Entry DOI: 10.7270/Q2R49QCV |
More data for this
Ligand-Target Pair | |
Receptor-type tyrosine-protein kinase FLT3
(Homo sapiens (Human)) | BDBM50185106
(2-(2-methylbenzamido)-4,5,6,7-tetrahydrobenzo[b]th...)Show InChI InChI=1S/C17H18N2O2S/c1-10-6-2-3-7-11(10)16(21)19-17-14(15(18)20)12-8-4-5-9-13(12)22-17/h2-3,6-7H,4-5,8-9H2,1H3,(H2,18,20)(H,19,21) | PDB
NCI pathway
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| n/a | n/a | 3.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of FLT3 |
Bioorg Med Chem Lett 16: 3282-6 (2006)
Article DOI: 10.1016/j.bmcl.2006.03.032
BindingDB Entry DOI: 10.7270/Q2R49QCV |
More data for this
Ligand-Target Pair | |
Receptor-type tyrosine-protein kinase FLT3
(Homo sapiens (Human)) | BDBM50185105
(2-(2-phenylacetamido)-4,5,6,7-tetrahydrobenzo[b]th...)Show InChI InChI=1S/C17H18N2O2S/c18-16(21)15-12-8-4-5-9-13(12)22-17(15)19-14(20)10-11-6-2-1-3-7-11/h1-3,6-7H,4-5,8-10H2,(H2,18,21)(H,19,20) | PDB
NCI pathway
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| n/a | n/a | 3.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of FLT3 |
Bioorg Med Chem Lett 16: 3282-6 (2006)
Article DOI: 10.1016/j.bmcl.2006.03.032
BindingDB Entry DOI: 10.7270/Q2R49QCV |
More data for this
Ligand-Target Pair | |
Receptor-type tyrosine-protein kinase FLT3
(Homo sapiens (Human)) | BDBM50185112
(2-(3-phenylpropanamido)-4,5,6,7-tetrahydrobenzo[b]...)Show InChI InChI=1S/C18H20N2O2S/c19-17(22)16-13-8-4-5-9-14(13)23-18(16)20-15(21)11-10-12-6-2-1-3-7-12/h1-3,6-7H,4-5,8-11H2,(H2,19,22)(H,20,21) | PDB
NCI pathway
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| n/a | n/a | 3.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of FLT3 |
Bioorg Med Chem Lett 16: 3282-6 (2006)
Article DOI: 10.1016/j.bmcl.2006.03.032
BindingDB Entry DOI: 10.7270/Q2R49QCV |
More data for this
Ligand-Target Pair | |
Receptor-type tyrosine-protein kinase FLT3
(Homo sapiens (Human)) | BDBM50185088
(2-(3,4-dimethoxybenzamido)-5,6,7,8-tetrahydro-4H-c...)Show InChI InChI=1S/C19H22N2O4S/c1-24-13-9-8-11(10-14(13)25-2)18(23)21-19-16(17(20)22)12-6-4-3-5-7-15(12)26-19/h8-10H,3-7H2,1-2H3,(H2,20,22)(H,21,23) | PDB
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| n/a | n/a | 6.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of FLT3 |
Bioorg Med Chem Lett 16: 3282-6 (2006)
Article DOI: 10.1016/j.bmcl.2006.03.032
BindingDB Entry DOI: 10.7270/Q2R49QCV |
More data for this
Ligand-Target Pair | |
Receptor-type tyrosine-protein kinase FLT3
(Homo sapiens (Human)) | BDBM50185107
(2-(2-methoxybenzamido)-4,5,6,7-tetrahydrobenzo[b]t...)Show InChI InChI=1S/C17H18N2O3S/c1-22-12-8-4-2-6-10(12)16(21)19-17-14(15(18)20)11-7-3-5-9-13(11)23-17/h2,4,6,8H,3,5,7,9H2,1H3,(H2,18,20)(H,19,21) | PDB
NCI pathway
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| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of FLT3 |
Bioorg Med Chem Lett 16: 3282-6 (2006)
Article DOI: 10.1016/j.bmcl.2006.03.032
BindingDB Entry DOI: 10.7270/Q2R49QCV |
More data for this
Ligand-Target Pair | |
Receptor-type tyrosine-protein kinase FLT3
(Homo sapiens (Human)) | BDBM50185118
(2-(3,4,5-trimethoxybenzamido)-4,5,6,7-tetrahydrobe...)Show SMILES COc1cc(cc(OC)c1OC)C(=O)Nc1sc2CCCCc2c1C(N)=O Show InChI InChI=1S/C19H22N2O5S/c1-24-12-8-10(9-13(25-2)16(12)26-3)18(23)21-19-15(17(20)22)11-6-4-5-7-14(11)27-19/h8-9H,4-7H2,1-3H3,(H2,20,22)(H,21,23) | PDB
NCI pathway
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| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of FLT3 |
Bioorg Med Chem Lett 16: 3282-6 (2006)
Article DOI: 10.1016/j.bmcl.2006.03.032
BindingDB Entry DOI: 10.7270/Q2R49QCV |
More data for this
Ligand-Target Pair | |
Receptor-type tyrosine-protein kinase FLT3
(Homo sapiens (Human)) | BDBM50185098
(2-(2-phenoxyacetamido)-4,5,6,7-tetrahydrobenzo[b]t...)Show InChI InChI=1S/C17H18N2O3S/c18-16(21)15-12-8-4-5-9-13(12)23-17(15)19-14(20)10-22-11-6-2-1-3-7-11/h1-3,6-7H,4-5,8-10H2,(H2,18,21)(H,19,20) | PDB
NCI pathway
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| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of FLT3 |
Bioorg Med Chem Lett 16: 3282-6 (2006)
Article DOI: 10.1016/j.bmcl.2006.03.032
BindingDB Entry DOI: 10.7270/Q2R49QCV |
More data for this
Ligand-Target Pair | |
Receptor-type tyrosine-protein kinase FLT3
(Homo sapiens (Human)) | BDBM50185100
(2-[(biphenyl-4-carbonyl)-amino]-4,5,6,7-tetrahydro...)Show SMILES NC(=O)c1c(NC(=O)c2ccc(cc2)-c2ccccc2)sc2CCCCc12 Show InChI InChI=1S/C22H20N2O2S/c23-20(25)19-17-8-4-5-9-18(17)27-22(19)24-21(26)16-12-10-15(11-13-16)14-6-2-1-3-7-14/h1-3,6-7,10-13H,4-5,8-9H2,(H2,23,25)(H,24,26) | PDB
NCI pathway
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| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of FLT3 |
Bioorg Med Chem Lett 16: 3282-6 (2006)
Article DOI: 10.1016/j.bmcl.2006.03.032
BindingDB Entry DOI: 10.7270/Q2R49QCV |
More data for this
Ligand-Target Pair | |
Receptor-type tyrosine-protein kinase FLT3
(Homo sapiens (Human)) | BDBM50185085
(2-(2-(phenylthio)acetamido)-4,5,6,7-tetrahydrobenz...)Show InChI InChI=1S/C17H18N2O2S2/c18-16(21)15-12-8-4-5-9-13(12)23-17(15)19-14(20)10-22-11-6-2-1-3-7-11/h1-3,6-7H,4-5,8-10H2,(H2,18,21)(H,19,20) | PDB
NCI pathway
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| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of FLT3 |
Bioorg Med Chem Lett 16: 3282-6 (2006)
Article DOI: 10.1016/j.bmcl.2006.03.032
BindingDB Entry DOI: 10.7270/Q2R49QCV |
More data for this
Ligand-Target Pair | |
Receptor-type tyrosine-protein kinase FLT3
(Homo sapiens (Human)) | BDBM50185078
(2-(2-(4-methoxyphenoxy)acetamido)-4,5,6,7-tetrahyd...)Show InChI InChI=1S/C18H20N2O4S/c1-23-11-6-8-12(9-7-11)24-10-15(21)20-18-16(17(19)22)13-4-2-3-5-14(13)25-18/h6-9H,2-5,10H2,1H3,(H2,19,22)(H,20,21) | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
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CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of FLT3 |
Bioorg Med Chem Lett 16: 3282-6 (2006)
Article DOI: 10.1016/j.bmcl.2006.03.032
BindingDB Entry DOI: 10.7270/Q2R49QCV |
More data for this
Ligand-Target Pair | |
Receptor-type tyrosine-protein kinase FLT3
(Homo sapiens (Human)) | BDBM50185116
(2-isobutyramido-4,5,6,7-tetrahydrobenzo[b]thiophen...)Show InChI InChI=1S/C13H18N2O2S/c1-7(2)12(17)15-13-10(11(14)16)8-5-3-4-6-9(8)18-13/h7H,3-6H2,1-2H3,(H2,14,16)(H,15,17) | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
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| Purchase
CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of FLT3 |
Bioorg Med Chem Lett 16: 3282-6 (2006)
Article DOI: 10.1016/j.bmcl.2006.03.032
BindingDB Entry DOI: 10.7270/Q2R49QCV |
More data for this
Ligand-Target Pair | |
Receptor-type tyrosine-protein kinase FLT3
(Homo sapiens (Human)) | BDBM50185097
(2-(4-phenoxybenzamido)-4,5,6,7-tetrahydrobenzo[b]t...)Show SMILES NC(=O)c1c(NC(=O)c2ccc(Oc3ccccc3)cc2)sc2CCCCc12 Show InChI InChI=1S/C22H20N2O3S/c23-20(25)19-17-8-4-5-9-18(17)28-22(19)24-21(26)14-10-12-16(13-11-14)27-15-6-2-1-3-7-15/h1-3,6-7,10-13H,4-5,8-9H2,(H2,23,25)(H,24,26) | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of FLT3 |
Bioorg Med Chem Lett 16: 3282-6 (2006)
Article DOI: 10.1016/j.bmcl.2006.03.032
BindingDB Entry DOI: 10.7270/Q2R49QCV |
More data for this
Ligand-Target Pair | |
Receptor-type tyrosine-protein kinase FLT3
(Homo sapiens (Human)) | BDBM50185103
(2-(cyclohexanecarboxamido)-4,5,6,7-tetrahydrobenzo...)Show InChI InChI=1S/C16H22N2O2S/c17-14(19)13-11-8-4-5-9-12(11)21-16(13)18-15(20)10-6-2-1-3-7-10/h10H,1-9H2,(H2,17,19)(H,18,20) | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of FLT3 |
Bioorg Med Chem Lett 16: 3282-6 (2006)
Article DOI: 10.1016/j.bmcl.2006.03.032
BindingDB Entry DOI: 10.7270/Q2R49QCV |
More data for this
Ligand-Target Pair | |
Receptor-type tyrosine-protein kinase FLT3
(Homo sapiens (Human)) | BDBM50185114
(2-(2-chlorobenzamido)-4,5,6,7-tetrahydrobenzo[b]th...)Show InChI InChI=1S/C16H15ClN2O2S/c17-11-7-3-1-5-9(11)15(21)19-16-13(14(18)20)10-6-2-4-8-12(10)22-16/h1,3,5,7H,2,4,6,8H2,(H2,18,20)(H,19,21) | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of FLT3 |
Bioorg Med Chem Lett 16: 3282-6 (2006)
Article DOI: 10.1016/j.bmcl.2006.03.032
BindingDB Entry DOI: 10.7270/Q2R49QCV |
More data for this
Ligand-Target Pair | |
Receptor-type tyrosine-protein kinase FLT3
(Homo sapiens (Human)) | BDBM50185108
(2-(3,4-dimethoxybenzamido)-4,5,6,7,8,9-hexahydrocy...)Show InChI InChI=1S/C20H24N2O4S/c1-25-14-10-9-12(11-15(14)26-2)19(24)22-20-17(18(21)23)13-7-5-3-4-6-8-16(13)27-20/h9-11H,3-8H2,1-2H3,(H2,21,23)(H,22,24) | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of FLT3 |
Bioorg Med Chem Lett 16: 3282-6 (2006)
Article DOI: 10.1016/j.bmcl.2006.03.032
BindingDB Entry DOI: 10.7270/Q2R49QCV |
More data for this
Ligand-Target Pair | |
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