Found 88 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50192487
((7,8-dimethoxy-10,11-dihydro-5H-2,4,5,11-tetraaza-...)Show SMILES COc1cc2CNc3c(N[C@H](C)c4ccccc4)ncnc3Nc2cc1OC Show InChI InChI=1S/C21H23N5O2/c1-13(14-7-5-4-6-8-14)25-20-19-21(24-12-23-20)26-16-10-18(28-3)17(27-2)9-15(16)11-22-19/h4-10,12-13,22H,11H2,1-3H3,(H2,23,24,25,26)/t13-/m1/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 150 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems Inc
Curated by ChEMBL
| Assay Description
Inhibition of EGFR measured as pGAT-biotin peptide phosphorylation in presence of 2.0 uM ATP by HTRF assay |
Bioorg Med Chem Lett 16: 5102-6 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.031
BindingDB Entry DOI: 10.7270/Q2K9374T |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50192474
(CHEMBL215191 | benzyl-(7,8-dimethoxy-10,11-dihydro...)Show InChI InChI=1S/C20H21N5O2/c1-26-16-8-14-11-21-18-19(22-10-13-6-4-3-5-7-13)23-12-24-20(18)25-15(14)9-17(16)27-2/h3-9,12,21H,10-11H2,1-2H3,(H2,22,23,24,25) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 200 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems Inc
Curated by ChEMBL
| Assay Description
Inhibition of EGFR measured as pGAT-biotin peptide phosphorylation in presence of 2.0 uM ATP by HTRF assay |
Bioorg Med Chem Lett 16: 5102-6 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.031
BindingDB Entry DOI: 10.7270/Q2K9374T |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50192498
((3-chloro-4-fluoro-benzyl)-(7,8-dimethoxy-10,11-di...)Show SMILES COc1cc2CNc3c(NCc4ccc(F)c(Cl)c4)ncnc3Nc2cc1OC Show InChI InChI=1S/C20H19ClFN5O2/c1-28-16-6-12-9-23-18-19(24-8-11-3-4-14(22)13(21)5-11)25-10-26-20(18)27-15(12)7-17(16)29-2/h3-7,10,23H,8-9H2,1-2H3,(H2,24,25,26,27) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 300 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems Inc
Curated by ChEMBL
| Assay Description
Inhibition of EGFR measured as pGAT-biotin peptide phosphorylation in presence of 2.0 uM ATP by HTRF assay |
Bioorg Med Chem Lett 16: 5102-6 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.031
BindingDB Entry DOI: 10.7270/Q2K9374T |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50192477
((3-chloro-2-fluoro-phenyl)-(7,8-dimethoxy-10,11-di...)Show InChI InChI=1S/C19H16ClFN4O3/c1-26-14-6-10-8-22-17-18(25-12-5-3-4-11(20)16(12)21)23-9-24-19(17)28-13(10)7-15(14)27-2/h3-7,9,22H,8H2,1-2H3,(H,23,24,25) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 300 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems Inc
Curated by ChEMBL
| Assay Description
Inhibition of EGFR measured as pGAT-biotin peptide phosphorylation in presence of 2.0 uM ATP by HTRF assay |
Bioorg Med Chem Lett 16: 5102-6 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.031
BindingDB Entry DOI: 10.7270/Q2K9374T |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50180448
((3-Bromo-phenyl)-(7,8-dimethoxy-10,11-dihydro-5-ox...)Show InChI InChI=1S/C19H17BrN4O3/c1-25-15-6-11-9-21-17-18(24-13-5-3-4-12(20)7-13)22-10-23-19(17)27-14(11)8-16(15)26-2/h3-8,10,21H,9H2,1-2H3,(H,22,23,24) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 300 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems Inc
Curated by ChEMBL
| Assay Description
Inhibition of EGFR measured as pGAT-biotin peptide phosphorylation in presence of 2.0 uM ATP by HTRF assay |
Bioorg Med Chem Lett 16: 5102-6 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.031
BindingDB Entry DOI: 10.7270/Q2K9374T |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50192471
((7,8-dimethoxy-10,11-dihydro-5-oxa-2,4,11-triaza-d...)Show InChI InChI=1S/C23H20N4O3/c1-28-19-10-16-12-24-21-22(25-13-26-23(21)30-18(16)11-20(19)29-2)27-17-8-7-14-5-3-4-6-15(14)9-17/h3-11,13,24H,12H2,1-2H3,(H,25,26,27) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 500 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems Inc
Curated by ChEMBL
| Assay Description
Inhibition of EGFR measured as pGAT-biotin peptide phosphorylation in presence of 2.0 uM ATP by HTRF assay |
Bioorg Med Chem Lett 16: 5102-6 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.031
BindingDB Entry DOI: 10.7270/Q2K9374T |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50180448
((3-Bromo-phenyl)-(7,8-dimethoxy-10,11-dihydro-5-ox...)Show InChI InChI=1S/C19H17BrN4O3/c1-25-15-6-11-9-21-17-18(24-13-5-3-4-12(20)7-13)22-10-23-19(17)27-14(11)8-16(15)26-2/h3-8,10,21H,9H2,1-2H3,(H,22,23,24) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 500 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems Inc
Curated by ChEMBL
| Assay Description
Inhibition of EGFR autophosphorylation in DiFi cells by ELISA |
Bioorg Med Chem Lett 16: 5102-6 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.031
BindingDB Entry DOI: 10.7270/Q2K9374T |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50192487
((7,8-dimethoxy-10,11-dihydro-5H-2,4,5,11-tetraaza-...)Show SMILES COc1cc2CNc3c(N[C@H](C)c4ccccc4)ncnc3Nc2cc1OC Show InChI InChI=1S/C21H23N5O2/c1-13(14-7-5-4-6-8-14)25-20-19-21(24-12-23-20)26-16-10-18(28-3)17(27-2)9-15(16)11-22-19/h4-10,12-13,22H,11H2,1-3H3,(H2,23,24,25,26)/t13-/m1/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 500 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems Inc
Curated by ChEMBL
| Assay Description
Inhibition of EGFR autophosphorylation in DiFi cells by ELISA |
Bioorg Med Chem Lett 16: 5102-6 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.031
BindingDB Entry DOI: 10.7270/Q2K9374T |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50180453
((3-Chloro-4-fluoro-phenyl)-(7,8-dimethoxy-10,11-di...)Show SMILES COc1cc2CNc3c(Nc4ccc(F)c(Cl)c4)ncnc3Oc2cc1OC Show InChI InChI=1S/C19H16ClFN4O3/c1-26-15-5-10-8-22-17-18(25-11-3-4-13(21)12(20)6-11)23-9-24-19(17)28-14(10)7-16(15)27-2/h3-7,9,22H,8H2,1-2H3,(H,23,24,25) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 700 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems Inc
Curated by ChEMBL
| Assay Description
Inhibition of EGFR autophosphorylation in DiFi cells by ELISA |
Bioorg Med Chem Lett 16: 5102-6 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.031
BindingDB Entry DOI: 10.7270/Q2K9374T |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50192478
(1-(3-bromo-phenoxy)-7,8-dimethoxy-10,11-dihydro-5-...)Show InChI InChI=1S/C19H16BrN3O4/c1-24-15-6-11-9-21-17-18(26-13-5-3-4-12(20)7-13)22-10-23-19(17)27-14(11)8-16(15)25-2/h3-8,10,21H,9H2,1-2H3 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 700 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems Inc
Curated by ChEMBL
| Assay Description
Inhibition of EGFR measured as pGAT-biotin peptide phosphorylation in presence of 2.0 uM ATP by HTRF assay |
Bioorg Med Chem Lett 16: 5102-6 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.031
BindingDB Entry DOI: 10.7270/Q2K9374T |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50192497
((7,8-dimethoxy-10,11-dihydro-5H-2,4,5,11-tetraaza-...)Show SMILES COc1cccc(CNc2ncnc3Nc4cc(OC)c(OC)cc4CNc23)c1 Show InChI InChI=1S/C21H23N5O3/c1-27-15-6-4-5-13(7-15)10-23-20-19-21(25-12-24-20)26-16-9-18(29-3)17(28-2)8-14(16)11-22-19/h4-9,12,22H,10-11H2,1-3H3,(H2,23,24,25,26) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 800 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems Inc
Curated by ChEMBL
| Assay Description
Inhibition of EGFR measured as pGAT-biotin peptide phosphorylation in presence of 2.0 uM ATP by HTRF assay |
Bioorg Med Chem Lett 16: 5102-6 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.031
BindingDB Entry DOI: 10.7270/Q2K9374T |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50192501
((7,8-dimethoxy-10,11-dihydro-5-oxa-2,4,11-triaza-d...)Show InChI InChI=1S/C21H18N4O3/c1-4-13-6-5-7-15(8-13)25-20-19-21(24-12-23-20)28-16-10-18(27-3)17(26-2)9-14(16)11-22-19/h1,5-10,12,22H,11H2,2-3H3,(H,23,24,25) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 900 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems Inc
Curated by ChEMBL
| Assay Description
Inhibition of EGFR autophosphorylation in DiFi cells by ELISA |
Bioorg Med Chem Lett 16: 5102-6 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.031
BindingDB Entry DOI: 10.7270/Q2K9374T |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50192474
(CHEMBL215191 | benzyl-(7,8-dimethoxy-10,11-dihydro...)Show InChI InChI=1S/C20H21N5O2/c1-26-16-8-14-11-21-18-19(22-10-13-6-4-3-5-7-13)23-12-24-20(18)25-15(14)9-17(16)27-2/h3-9,12,21H,10-11H2,1-2H3,(H2,22,23,24,25) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 900 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems Inc
Curated by ChEMBL
| Assay Description
Inhibition of EGFR autophosphorylation in DiFi cells by ELISA |
Bioorg Med Chem Lett 16: 5102-6 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.031
BindingDB Entry DOI: 10.7270/Q2K9374T |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50192496
(1-(3-chloro-phenylsulfanyl)-7,8-dimethoxy-10,11-di...)Show InChI InChI=1S/C19H16ClN3O3S/c1-24-15-6-11-9-21-17-18(26-14(11)8-16(15)25-2)22-10-23-19(17)27-13-5-3-4-12(20)7-13/h3-8,10,21H,9H2,1-2H3 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems Inc
Curated by ChEMBL
| Assay Description
Inhibition of EGFR measured as pGAT-biotin peptide phosphorylation in presence of 2.0 uM ATP by HTRF assay |
Bioorg Med Chem Lett 16: 5102-6 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.031
BindingDB Entry DOI: 10.7270/Q2K9374T |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50192479
((5-chloro-2-fluoro-phenyl)-(7,8-dimethoxy-10,11-di...)Show InChI InChI=1S/C19H16ClFN4O3/c1-26-15-5-10-8-22-17-18(25-13-6-11(20)3-4-12(13)21)23-9-24-19(17)28-14(10)7-16(15)27-2/h3-7,9,22H,8H2,1-2H3,(H,23,24,25) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems Inc
Curated by ChEMBL
| Assay Description
Inhibition of EGFR measured as pGAT-biotin peptide phosphorylation in presence of 2.0 uM ATP by HTRF assay |
Bioorg Med Chem Lett 16: 5102-6 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.031
BindingDB Entry DOI: 10.7270/Q2K9374T |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50180453
((3-Chloro-4-fluoro-phenyl)-(7,8-dimethoxy-10,11-di...)Show SMILES COc1cc2CNc3c(Nc4ccc(F)c(Cl)c4)ncnc3Oc2cc1OC Show InChI InChI=1S/C19H16ClFN4O3/c1-26-15-5-10-8-22-17-18(25-11-3-4-13(21)12(20)6-11)23-9-24-19(17)28-14(10)7-16(15)27-2/h3-7,9,22H,8H2,1-2H3,(H,23,24,25) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems Inc
Curated by ChEMBL
| Assay Description
Inhibition of EGFR measured as pGAT-biotin peptide phosphorylation in presence of 2.0 uM ATP by HTRF assay |
Bioorg Med Chem Lett 16: 5102-6 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.031
BindingDB Entry DOI: 10.7270/Q2K9374T |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50192480
((7,8-dimethoxy-10,11-dihydro-5-oxa-2,4,11-triaza-d...)Show SMILES COc1cc2CNc3c(Nc4ccc5c[nH]nc5c4)ncnc3Oc2cc1OC Show InChI InChI=1S/C20H18N6O3/c1-27-16-5-12-8-21-18-19(25-13-4-3-11-9-24-26-14(11)6-13)22-10-23-20(18)29-15(12)7-17(16)28-2/h3-7,9-10,21H,8H2,1-2H3,(H,24,26)(H,22,23,25) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems Inc
Curated by ChEMBL
| Assay Description
Inhibition of EGFR measured as pGAT-biotin peptide phosphorylation in presence of 2.0 uM ATP by HTRF assay |
Bioorg Med Chem Lett 16: 5102-6 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.031
BindingDB Entry DOI: 10.7270/Q2K9374T |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50192489
(1-(3-bromo-phenylsulfanyl)-7,8-dimethoxy-10,11-dih...)Show InChI InChI=1S/C19H16BrN3O3S/c1-24-15-6-11-9-21-17-18(26-14(11)8-16(15)25-2)22-10-23-19(17)27-13-5-3-4-12(20)7-13/h3-8,10,21H,9H2,1-2H3 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems Inc
Curated by ChEMBL
| Assay Description
Inhibition of EGFR autophosphorylation in DiFi cells by ELISA |
Bioorg Med Chem Lett 16: 5102-6 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.031
BindingDB Entry DOI: 10.7270/Q2K9374T |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50192473
(7-(3-bromophenoxy)-13,14-dimethoxy-9-methyl-2-oxa-...)Show SMILES COc1cc2CN(C)c3c(Oc4cccc(Br)c4)ncnc3Oc2cc1OC Show InChI InChI=1S/C20H18BrN3O4/c1-24-10-12-7-16(25-2)17(26-3)9-15(12)28-20-18(24)19(22-11-23-20)27-14-6-4-5-13(21)8-14/h4-9,11H,10H2,1-3H3 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems Inc
Curated by ChEMBL
| Assay Description
Inhibition of EGFR measured as pGAT-biotin peptide phosphorylation in presence of 2.0 uM ATP by HTRF assay |
Bioorg Med Chem Lett 16: 5102-6 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.031
BindingDB Entry DOI: 10.7270/Q2K9374T |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50192489
(1-(3-bromo-phenylsulfanyl)-7,8-dimethoxy-10,11-dih...)Show InChI InChI=1S/C19H16BrN3O3S/c1-24-15-6-11-9-21-17-18(26-14(11)8-16(15)25-2)22-10-23-19(17)27-13-5-3-4-12(20)7-13/h3-8,10,21H,9H2,1-2H3 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems Inc
Curated by ChEMBL
| Assay Description
Inhibition of EGFR measured as pGAT-biotin peptide phosphorylation in presence of 2.0 uM ATP by HTRF assay |
Bioorg Med Chem Lett 16: 5102-6 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.031
BindingDB Entry DOI: 10.7270/Q2K9374T |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50192500
((3-bromo-phenyl)-(7,8-dimethoxy-10,11-dihydro-5H-2...)Show InChI InChI=1S/C19H18BrN5O2/c1-26-15-6-11-9-21-17-18(24-13-5-3-4-12(20)7-13)22-10-23-19(17)25-14(11)8-16(15)27-2/h3-8,10,21H,9H2,1-2H3,(H2,22,23,24,25) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems Inc
Curated by ChEMBL
| Assay Description
Inhibition of EGFR measured as pGAT-biotin peptide phosphorylation in presence of 2.0 uM ATP by HTRF assay |
Bioorg Med Chem Lett 16: 5102-6 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.031
BindingDB Entry DOI: 10.7270/Q2K9374T |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50192483
(1-(3-bromo-phenylsulfanyl)-7,8-dimethoxy-10,11-dih...)Show InChI InChI=1S/C19H16BrN3O2S2/c1-24-14-6-11-9-21-17-18(26-13-5-3-4-12(20)7-13)22-10-23-19(17)27-16(11)8-15(14)25-2/h3-8,10,21H,9H2,1-2H3 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems Inc
Curated by ChEMBL
| Assay Description
Inhibition of EGFR measured as pGAT-biotin peptide phosphorylation in presence of 2.0 uM ATP by HTRF assay |
Bioorg Med Chem Lett 16: 5102-6 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.031
BindingDB Entry DOI: 10.7270/Q2K9374T |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50192498
((3-chloro-4-fluoro-benzyl)-(7,8-dimethoxy-10,11-di...)Show SMILES COc1cc2CNc3c(NCc4ccc(F)c(Cl)c4)ncnc3Nc2cc1OC Show InChI InChI=1S/C20H19ClFN5O2/c1-28-16-6-12-9-23-18-19(24-8-11-3-4-14(22)13(21)5-11)25-10-26-20(18)27-15(12)7-17(16)29-2/h3-7,10,23H,8-9H2,1-2H3,(H2,24,25,26,27) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems Inc
Curated by ChEMBL
| Assay Description
Inhibition of EGFR autophosphorylation in DiFi cells by ELISA |
Bioorg Med Chem Lett 16: 5102-6 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.031
BindingDB Entry DOI: 10.7270/Q2K9374T |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50192478
(1-(3-bromo-phenoxy)-7,8-dimethoxy-10,11-dihydro-5-...)Show InChI InChI=1S/C19H16BrN3O4/c1-24-15-6-11-9-21-17-18(26-13-5-3-4-12(20)7-13)22-10-23-19(17)27-14(11)8-16(15)25-2/h3-8,10,21H,9H2,1-2H3 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems Inc
Curated by ChEMBL
| Assay Description
Inhibition of EGFR autophosphorylation in DiFi cells by ELISA |
Bioorg Med Chem Lett 16: 5102-6 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.031
BindingDB Entry DOI: 10.7270/Q2K9374T |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50192474
(CHEMBL215191 | benzyl-(7,8-dimethoxy-10,11-dihydro...)Show InChI InChI=1S/C20H21N5O2/c1-26-16-8-14-11-21-18-19(22-10-13-6-4-3-5-7-13)23-12-24-20(18)25-15(14)9-17(16)27-2/h3-9,12,21H,10-11H2,1-2H3,(H2,22,23,24,25) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems Inc
Curated by ChEMBL
| Assay Description
Inhibition of KDR measured as pGAT-biotin peptide phosphorylation by HTRF assay |
Bioorg Med Chem Lett 16: 5102-6 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.031
BindingDB Entry DOI: 10.7270/Q2K9374T |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50192487
((7,8-dimethoxy-10,11-dihydro-5H-2,4,5,11-tetraaza-...)Show SMILES COc1cc2CNc3c(N[C@H](C)c4ccccc4)ncnc3Nc2cc1OC Show InChI InChI=1S/C21H23N5O2/c1-13(14-7-5-4-6-8-14)25-20-19-21(24-12-23-20)26-16-10-18(28-3)17(27-2)9-15(16)11-22-19/h4-10,12-13,22H,11H2,1-3H3,(H2,23,24,25,26)/t13-/m1/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems Inc
Curated by ChEMBL
| Assay Description
Inhibition of KDR measured as pGAT-biotin peptide phosphorylation by HTRF assay |
Bioorg Med Chem Lett 16: 5102-6 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.031
BindingDB Entry DOI: 10.7270/Q2K9374T |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50192498
((3-chloro-4-fluoro-benzyl)-(7,8-dimethoxy-10,11-di...)Show SMILES COc1cc2CNc3c(NCc4ccc(F)c(Cl)c4)ncnc3Nc2cc1OC Show InChI InChI=1S/C20H19ClFN5O2/c1-28-16-6-12-9-23-18-19(24-8-11-3-4-14(22)13(21)5-11)25-10-26-20(18)27-15(12)7-17(16)29-2/h3-7,10,23H,8-9H2,1-2H3,(H2,24,25,26,27) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems Inc
Curated by ChEMBL
| Assay Description
Inhibition of KDR measured as pGAT-biotin peptide phosphorylation by HTRF assay |
Bioorg Med Chem Lett 16: 5102-6 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.031
BindingDB Entry DOI: 10.7270/Q2K9374T |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50192497
((7,8-dimethoxy-10,11-dihydro-5H-2,4,5,11-tetraaza-...)Show SMILES COc1cccc(CNc2ncnc3Nc4cc(OC)c(OC)cc4CNc23)c1 Show InChI InChI=1S/C21H23N5O3/c1-27-15-6-4-5-13(7-15)10-23-20-19-21(25-12-24-20)26-16-9-18(29-3)17(28-2)8-14(16)11-22-19/h4-9,12,22H,10-11H2,1-3H3,(H2,23,24,25,26) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems Inc
Curated by ChEMBL
| Assay Description
Inhibition of KDR measured as pGAT-biotin peptide phosphorylation by HTRF assay |
Bioorg Med Chem Lett 16: 5102-6 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.031
BindingDB Entry DOI: 10.7270/Q2K9374T |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50192471
((7,8-dimethoxy-10,11-dihydro-5-oxa-2,4,11-triaza-d...)Show InChI InChI=1S/C23H20N4O3/c1-28-19-10-16-12-24-21-22(25-13-26-23(21)30-18(16)11-20(19)29-2)27-17-8-7-14-5-3-4-6-15(14)9-17/h3-11,13,24H,12H2,1-2H3,(H,25,26,27) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems Inc
Curated by ChEMBL
| Assay Description
Inhibition of EGFR autophosphorylation in DiFi cells by ELISA |
Bioorg Med Chem Lett 16: 5102-6 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.031
BindingDB Entry DOI: 10.7270/Q2K9374T |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50192496
(1-(3-chloro-phenylsulfanyl)-7,8-dimethoxy-10,11-di...)Show InChI InChI=1S/C19H16ClN3O3S/c1-24-15-6-11-9-21-17-18(26-14(11)8-16(15)25-2)22-10-23-19(17)27-13-5-3-4-12(20)7-13/h3-8,10,21H,9H2,1-2H3 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems Inc
Curated by ChEMBL
| Assay Description
Inhibition of EGFR autophosphorylation in DiFi cells by ELISA |
Bioorg Med Chem Lett 16: 5102-6 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.031
BindingDB Entry DOI: 10.7270/Q2K9374T |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50192475
(1-(3-chloro-phenylsulfanyl)-7,8-dimethoxy-10,11-di...)Show InChI InChI=1S/C19H16ClN3O2S2/c1-24-14-6-11-9-21-17-18(26-13-5-3-4-12(20)7-13)22-10-23-19(17)27-16(11)8-15(14)25-2/h3-8,10,21H,9H2,1-2H3 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems Inc
Curated by ChEMBL
| Assay Description
Inhibition of EGFR measured as pGAT-biotin peptide phosphorylation in presence of 2.0 uM ATP by HTRF assay |
Bioorg Med Chem Lett 16: 5102-6 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.031
BindingDB Entry DOI: 10.7270/Q2K9374T |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50192501
((7,8-dimethoxy-10,11-dihydro-5-oxa-2,4,11-triaza-d...)Show InChI InChI=1S/C21H18N4O3/c1-4-13-6-5-7-15(8-13)25-20-19-21(24-12-23-20)28-16-10-18(27-3)17(26-2)9-14(16)11-22-19/h1,5-10,12,22H,11H2,2-3H3,(H,23,24,25) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems Inc
Curated by ChEMBL
| Assay Description
Inhibition of EGFR measured as pGAT-biotin peptide phosphorylation in presence of 2.0 uM ATP by HTRF assay |
Bioorg Med Chem Lett 16: 5102-6 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.031
BindingDB Entry DOI: 10.7270/Q2K9374T |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50192493
((2-chloro-4-fluoro-phenyl)-(7,8-dimethoxy-10,11-di...)Show InChI InChI=1S/C19H16ClFN4O3/c1-26-15-5-10-8-22-17-18(25-13-4-3-11(21)6-12(13)20)23-9-24-19(17)28-14(10)7-16(15)27-2/h3-7,9,22H,8H2,1-2H3,(H,23,24,25) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems Inc
Curated by ChEMBL
| Assay Description
Inhibition of EGFR measured as pGAT-biotin peptide phosphorylation in presence of 2.0 uM ATP by HTRF assay |
Bioorg Med Chem Lett 16: 5102-6 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.031
BindingDB Entry DOI: 10.7270/Q2K9374T |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50192479
((5-chloro-2-fluoro-phenyl)-(7,8-dimethoxy-10,11-di...)Show InChI InChI=1S/C19H16ClFN4O3/c1-26-15-5-10-8-22-17-18(25-13-6-11(20)3-4-12(13)21)23-9-24-19(17)28-14(10)7-16(15)27-2/h3-7,9,22H,8H2,1-2H3,(H,23,24,25) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems Inc
Curated by ChEMBL
| Assay Description
Inhibition of EGFR autophosphorylation in DiFi cells by ELISA |
Bioorg Med Chem Lett 16: 5102-6 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.031
BindingDB Entry DOI: 10.7270/Q2K9374T |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50192472
((7,8-dimethoxy-10,11-dihydro-5-oxa-2,4,11-triaza-d...)Show InChI InChI=1S/C20H20N4O3/c1-12-5-4-6-14(7-12)24-19-18-20(23-11-22-19)27-15-9-17(26-3)16(25-2)8-13(15)10-21-18/h4-9,11,21H,10H2,1-3H3,(H,22,23,24) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 4.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems Inc
Curated by ChEMBL
| Assay Description
Inhibition of EGFR autophosphorylation in DiFi cells by ELISA |
Bioorg Med Chem Lett 16: 5102-6 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.031
BindingDB Entry DOI: 10.7270/Q2K9374T |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50192486
(1-(3-chloro-2-fluoro-phenoxy)-7,8-dimethoxy-10,11-...)Show InChI InChI=1S/C19H15ClFN3O4/c1-25-14-6-10-8-22-17-18(27-12-5-3-4-11(20)16(12)21)23-9-24-19(17)28-13(10)7-15(14)26-2/h3-7,9,22H,8H2,1-2H3 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 4.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems Inc
Curated by ChEMBL
| Assay Description
Inhibition of EGFR measured as pGAT-biotin peptide phosphorylation in presence of 2.0 uM ATP by HTRF assay |
Bioorg Med Chem Lett 16: 5102-6 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.031
BindingDB Entry DOI: 10.7270/Q2K9374T |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50192477
((3-chloro-2-fluoro-phenyl)-(7,8-dimethoxy-10,11-di...)Show InChI InChI=1S/C19H16ClFN4O3/c1-26-14-6-10-8-22-17-18(25-12-5-3-4-11(20)16(12)21)23-9-24-19(17)28-13(10)7-15(14)27-2/h3-7,9,22H,8H2,1-2H3,(H,23,24,25) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 4.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems Inc
Curated by ChEMBL
| Assay Description
Inhibition of EGFR autophosphorylation in DiFi cells by ELISA |
Bioorg Med Chem Lett 16: 5102-6 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.031
BindingDB Entry DOI: 10.7270/Q2K9374T |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50192491
(CHEMBL377730 | benzothiazol-6-yl-(7,8-dimethoxy-10...)Show InChI InChI=1S/C20H17N5O3S/c1-26-15-5-11-8-21-18-19(25-12-3-4-13-17(6-12)29-10-24-13)22-9-23-20(18)28-14(11)7-16(15)27-2/h3-7,9-10,21H,8H2,1-2H3,(H,22,23,25) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 5.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems Inc
Curated by ChEMBL
| Assay Description
Inhibition of EGFR measured as pGAT-biotin peptide phosphorylation in presence of 2.0 uM ATP by HTRF assay |
Bioorg Med Chem Lett 16: 5102-6 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.031
BindingDB Entry DOI: 10.7270/Q2K9374T |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50192509
((3-bromo-phenyl)-(7,8-dimethoxy-10,11-dihydro-5-th...)Show InChI InChI=1S/C19H17BrN4O2S/c1-25-14-6-11-9-21-17-18(24-13-5-3-4-12(20)7-13)22-10-23-19(17)27-16(11)8-15(14)26-2/h3-8,10,21H,9H2,1-2H3,(H,22,23,24) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 5.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems Inc
Curated by ChEMBL
| Assay Description
Inhibition of EGFR measured as pGAT-biotin peptide phosphorylation in presence of 2.0 uM ATP by HTRF assay |
Bioorg Med Chem Lett 16: 5102-6 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.031
BindingDB Entry DOI: 10.7270/Q2K9374T |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50192473
(7-(3-bromophenoxy)-13,14-dimethoxy-9-methyl-2-oxa-...)Show SMILES COc1cc2CN(C)c3c(Oc4cccc(Br)c4)ncnc3Oc2cc1OC Show InChI InChI=1S/C20H18BrN3O4/c1-24-10-12-7-16(25-2)17(26-3)9-15(12)28-20-18(24)19(22-11-23-20)27-14-6-4-5-13(21)8-14/h4-9,11H,10H2,1-3H3 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 6.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems Inc
Curated by ChEMBL
| Assay Description
Inhibition of EGFR autophosphorylation in DiFi cells by ELISA |
Bioorg Med Chem Lett 16: 5102-6 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.031
BindingDB Entry DOI: 10.7270/Q2K9374T |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50192490
((7,8-dimethoxy-10,11-dihydro-5-oxa-2,4,11-triaza-d...)Show InChI InChI=1S/C19H17FN4O3/c1-25-15-7-11-9-21-17-18(24-13-5-3-12(20)4-6-13)22-10-23-19(17)27-14(11)8-16(15)26-2/h3-8,10,21H,9H2,1-2H3,(H,22,23,24) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 7.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems Inc
Curated by ChEMBL
| Assay Description
Inhibition of EGFR measured as pGAT-biotin peptide phosphorylation in presence of 2.0 uM ATP by HTRF assay |
Bioorg Med Chem Lett 16: 5102-6 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.031
BindingDB Entry DOI: 10.7270/Q2K9374T |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50192472
((7,8-dimethoxy-10,11-dihydro-5-oxa-2,4,11-triaza-d...)Show InChI InChI=1S/C20H20N4O3/c1-12-5-4-6-14(7-12)24-19-18-20(23-11-22-19)27-15-9-17(26-3)16(25-2)8-13(15)10-21-18/h4-9,11,21H,10H2,1-3H3,(H,22,23,24) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 7.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems Inc
Curated by ChEMBL
| Assay Description
Inhibition of EGFR measured as pGAT-biotin peptide phosphorylation in presence of 2.0 uM ATP by HTRF assay |
Bioorg Med Chem Lett 16: 5102-6 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.031
BindingDB Entry DOI: 10.7270/Q2K9374T |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50192490
((7,8-dimethoxy-10,11-dihydro-5-oxa-2,4,11-triaza-d...)Show InChI InChI=1S/C19H17FN4O3/c1-25-15-7-11-9-21-17-18(24-13-5-3-12(20)4-6-13)22-10-23-19(17)27-14(11)8-16(15)26-2/h3-8,10,21H,9H2,1-2H3,(H,22,23,24) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 7.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems Inc
Curated by ChEMBL
| Assay Description
Inhibition of EGFR autophosphorylation in DiFi cells by ELISA |
Bioorg Med Chem Lett 16: 5102-6 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.031
BindingDB Entry DOI: 10.7270/Q2K9374T |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50192512
((3-chloro-4-fluoro-phenyl)-(7,8-dimethoxy-10,11-di...)Show SMILES COc1cc2CNc3c(Nc4ccc(F)c(Cl)c4)ncnc3Sc2cc1OC Show InChI InChI=1S/C19H16ClFN4O2S/c1-26-14-5-10-8-22-17-18(25-11-3-4-13(21)12(20)6-11)23-9-24-19(17)28-16(10)7-15(14)27-2/h3-7,9,22H,8H2,1-2H3,(H,23,24,25) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 8.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems Inc
Curated by ChEMBL
| Assay Description
Inhibition of EGFR measured as pGAT-biotin peptide phosphorylation in presence of 2.0 uM ATP by HTRF assay |
Bioorg Med Chem Lett 16: 5102-6 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.031
BindingDB Entry DOI: 10.7270/Q2K9374T |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50192484
((4-bromo-phenyl)-(7,8-dimethoxy-10,11-dihydro-5-ox...)Show InChI InChI=1S/C19H17BrN4O3/c1-25-15-7-11-9-21-17-18(24-13-5-3-12(20)4-6-13)22-10-23-19(17)27-14(11)8-16(15)26-2/h3-8,10,21H,9H2,1-2H3,(H,22,23,24) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 8.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems Inc
Curated by ChEMBL
| Assay Description
Inhibition of EGFR measured as pGAT-biotin peptide phosphorylation in presence of 2.0 uM ATP by HTRF assay |
Bioorg Med Chem Lett 16: 5102-6 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.031
BindingDB Entry DOI: 10.7270/Q2K9374T |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50192470
((3-chloro-2-fluoro-phenyl)-(7,8-dimethoxy-3-methyl...)Show SMILES COc1cc2CNc3c(Nc4cccc(Cl)c4F)nc(C)nc3Oc2cc1OC Show InChI InChI=1S/C20H18ClFN4O3/c1-10-24-19(26-13-6-4-5-12(21)17(13)22)18-20(25-10)29-14-8-16(28-3)15(27-2)7-11(14)9-23-18/h4-8,23H,9H2,1-3H3,(H,24,25,26) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems Inc
Curated by ChEMBL
| Assay Description
Inhibition of KDR measured as pGAT-biotin peptide phosphorylation by HTRF assay |
Bioorg Med Chem Lett 16: 5102-6 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.031
BindingDB Entry DOI: 10.7270/Q2K9374T |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50192501
((7,8-dimethoxy-10,11-dihydro-5-oxa-2,4,11-triaza-d...)Show InChI InChI=1S/C21H18N4O3/c1-4-13-6-5-7-15(8-13)25-20-19-21(24-12-23-20)28-16-10-18(27-3)17(26-2)9-14(16)11-22-19/h1,5-10,12,22H,11H2,2-3H3,(H,23,24,25) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems Inc
Curated by ChEMBL
| Assay Description
Inhibition of KDR measured as pGAT-biotin peptide phosphorylation by HTRF assay |
Bioorg Med Chem Lett 16: 5102-6 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.031
BindingDB Entry DOI: 10.7270/Q2K9374T |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50192477
((3-chloro-2-fluoro-phenyl)-(7,8-dimethoxy-10,11-di...)Show InChI InChI=1S/C19H16ClFN4O3/c1-26-14-6-10-8-22-17-18(25-12-5-3-4-11(20)16(12)21)23-9-24-19(17)28-13(10)7-15(14)27-2/h3-7,9,22H,8H2,1-2H3,(H,23,24,25) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems Inc
Curated by ChEMBL
| Assay Description
Inhibition of KDR measured as pGAT-biotin peptide phosphorylation by HTRF assay |
Bioorg Med Chem Lett 16: 5102-6 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.031
BindingDB Entry DOI: 10.7270/Q2K9374T |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50192472
((7,8-dimethoxy-10,11-dihydro-5-oxa-2,4,11-triaza-d...)Show InChI InChI=1S/C20H20N4O3/c1-12-5-4-6-14(7-12)24-19-18-20(23-11-22-19)27-15-9-17(26-3)16(25-2)8-13(15)10-21-18/h4-9,11,21H,10H2,1-3H3,(H,22,23,24) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems Inc
Curated by ChEMBL
| Assay Description
Inhibition of KDR measured as pGAT-biotin peptide phosphorylation by HTRF assay |
Bioorg Med Chem Lett 16: 5102-6 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.031
BindingDB Entry DOI: 10.7270/Q2K9374T |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50180448
((3-Bromo-phenyl)-(7,8-dimethoxy-10,11-dihydro-5-ox...)Show InChI InChI=1S/C19H17BrN4O3/c1-25-15-6-11-9-21-17-18(24-13-5-3-4-12(20)7-13)22-10-23-19(17)27-14(11)8-16(15)26-2/h3-8,10,21H,9H2,1-2H3,(H,22,23,24) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems Inc
Curated by ChEMBL
| Assay Description
Inhibition of KDR measured as pGAT-biotin peptide phosphorylation by HTRF assay |
Bioorg Med Chem Lett 16: 5102-6 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.031
BindingDB Entry DOI: 10.7270/Q2K9374T |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50192484
((4-bromo-phenyl)-(7,8-dimethoxy-10,11-dihydro-5-ox...)Show InChI InChI=1S/C19H17BrN4O3/c1-25-15-7-11-9-21-17-18(24-13-5-3-12(20)4-6-13)22-10-23-19(17)27-14(11)8-16(15)26-2/h3-8,10,21H,9H2,1-2H3,(H,22,23,24) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems Inc
Curated by ChEMBL
| Assay Description
Inhibition of KDR measured as pGAT-biotin peptide phosphorylation by HTRF assay |
Bioorg Med Chem Lett 16: 5102-6 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.031
BindingDB Entry DOI: 10.7270/Q2K9374T |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50192496
(1-(3-chloro-phenylsulfanyl)-7,8-dimethoxy-10,11-di...)Show InChI InChI=1S/C19H16ClN3O3S/c1-24-15-6-11-9-21-17-18(26-14(11)8-16(15)25-2)22-10-23-19(17)27-13-5-3-4-12(20)7-13/h3-8,10,21H,9H2,1-2H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems Inc
Curated by ChEMBL
| Assay Description
Inhibition of KDR measured as pGAT-biotin peptide phosphorylation by HTRF assay |
Bioorg Med Chem Lett 16: 5102-6 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.031
BindingDB Entry DOI: 10.7270/Q2K9374T |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50192489
(1-(3-bromo-phenylsulfanyl)-7,8-dimethoxy-10,11-dih...)Show InChI InChI=1S/C19H16BrN3O3S/c1-24-15-6-11-9-21-17-18(26-14(11)8-16(15)25-2)22-10-23-19(17)27-13-5-3-4-12(20)7-13/h3-8,10,21H,9H2,1-2H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems Inc
Curated by ChEMBL
| Assay Description
Inhibition of KDR measured as pGAT-biotin peptide phosphorylation by HTRF assay |
Bioorg Med Chem Lett 16: 5102-6 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.031
BindingDB Entry DOI: 10.7270/Q2K9374T |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50192490
((7,8-dimethoxy-10,11-dihydro-5-oxa-2,4,11-triaza-d...)Show InChI InChI=1S/C19H17FN4O3/c1-25-15-7-11-9-21-17-18(24-13-5-3-12(20)4-6-13)22-10-23-19(17)27-14(11)8-16(15)26-2/h3-8,10,21H,9H2,1-2H3,(H,22,23,24) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems Inc
Curated by ChEMBL
| Assay Description
Inhibition of KDR measured as pGAT-biotin peptide phosphorylation by HTRF assay |
Bioorg Med Chem Lett 16: 5102-6 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.031
BindingDB Entry DOI: 10.7270/Q2K9374T |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50192471
((7,8-dimethoxy-10,11-dihydro-5-oxa-2,4,11-triaza-d...)Show InChI InChI=1S/C23H20N4O3/c1-28-19-10-16-12-24-21-22(25-13-26-23(21)30-18(16)11-20(19)29-2)27-17-8-7-14-5-3-4-6-15(14)9-17/h3-11,13,24H,12H2,1-2H3,(H,25,26,27) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems Inc
Curated by ChEMBL
| Assay Description
Inhibition of KDR measured as pGAT-biotin peptide phosphorylation by HTRF assay |
Bioorg Med Chem Lett 16: 5102-6 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.031
BindingDB Entry DOI: 10.7270/Q2K9374T |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50192480
((7,8-dimethoxy-10,11-dihydro-5-oxa-2,4,11-triaza-d...)Show SMILES COc1cc2CNc3c(Nc4ccc5c[nH]nc5c4)ncnc3Oc2cc1OC Show InChI InChI=1S/C20H18N6O3/c1-27-16-5-12-8-21-18-19(25-13-4-3-11-9-24-26-14(11)6-13)22-10-23-20(18)29-15(12)7-17(16)28-2/h3-7,9-10,21H,8H2,1-2H3,(H,24,26)(H,22,23,25) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems Inc
Curated by ChEMBL
| Assay Description
Inhibition of KDR measured as pGAT-biotin peptide phosphorylation by HTRF assay |
Bioorg Med Chem Lett 16: 5102-6 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.031
BindingDB Entry DOI: 10.7270/Q2K9374T |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50192504
(1-(3-chloro-4-fluoro-phenoxy)-7,8-dimethoxy-11-met...)Show SMILES COc1cc2CN(C)c3c(Oc4ccc(F)c(Cl)c4)ncnc3Oc2cc1OC Show InChI InChI=1S/C20H17ClFN3O4/c1-25-9-11-6-16(26-2)17(27-3)8-15(11)29-20-18(25)19(23-10-24-20)28-12-4-5-14(22)13(21)7-12/h4-8,10H,9H2,1-3H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems Inc
Curated by ChEMBL
| Assay Description
Inhibition of KDR measured as pGAT-biotin peptide phosphorylation by HTRF assay |
Bioorg Med Chem Lett 16: 5102-6 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.031
BindingDB Entry DOI: 10.7270/Q2K9374T |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50192473
(7-(3-bromophenoxy)-13,14-dimethoxy-9-methyl-2-oxa-...)Show SMILES COc1cc2CN(C)c3c(Oc4cccc(Br)c4)ncnc3Oc2cc1OC Show InChI InChI=1S/C20H18BrN3O4/c1-24-10-12-7-16(25-2)17(26-3)9-15(12)28-20-18(24)19(22-11-23-20)27-14-6-4-5-13(21)8-14/h4-9,11H,10H2,1-3H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems Inc
Curated by ChEMBL
| Assay Description
Inhibition of KDR measured as pGAT-biotin peptide phosphorylation by HTRF assay |
Bioorg Med Chem Lett 16: 5102-6 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.031
BindingDB Entry DOI: 10.7270/Q2K9374T |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50192479
((5-chloro-2-fluoro-phenyl)-(7,8-dimethoxy-10,11-di...)Show InChI InChI=1S/C19H16ClFN4O3/c1-26-15-5-10-8-22-17-18(25-13-6-11(20)3-4-12(13)21)23-9-24-19(17)28-14(10)7-16(15)27-2/h3-7,9,22H,8H2,1-2H3,(H,23,24,25) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems Inc
Curated by ChEMBL
| Assay Description
Inhibition of KDR measured as pGAT-biotin peptide phosphorylation by HTRF assay |
Bioorg Med Chem Lett 16: 5102-6 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.031
BindingDB Entry DOI: 10.7270/Q2K9374T |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50192491
(CHEMBL377730 | benzothiazol-6-yl-(7,8-dimethoxy-10...)Show InChI InChI=1S/C20H17N5O3S/c1-26-15-5-11-8-21-18-19(25-12-3-4-13-17(6-12)29-10-24-13)22-9-23-20(18)28-14(11)7-16(15)27-2/h3-7,9-10,21H,8H2,1-2H3,(H,22,23,25) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems Inc
Curated by ChEMBL
| Assay Description
Inhibition of KDR measured as pGAT-biotin peptide phosphorylation by HTRF assay |
Bioorg Med Chem Lett 16: 5102-6 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.031
BindingDB Entry DOI: 10.7270/Q2K9374T |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50180453
((3-Chloro-4-fluoro-phenyl)-(7,8-dimethoxy-10,11-di...)Show SMILES COc1cc2CNc3c(Nc4ccc(F)c(Cl)c4)ncnc3Oc2cc1OC Show InChI InChI=1S/C19H16ClFN4O3/c1-26-15-5-10-8-22-17-18(25-11-3-4-13(21)12(20)6-11)23-9-24-19(17)28-14(10)7-16(15)27-2/h3-7,9,22H,8H2,1-2H3,(H,23,24,25) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems Inc
Curated by ChEMBL
| Assay Description
Inhibition of KDR measured as pGAT-biotin peptide phosphorylation by HTRF assay |
Bioorg Med Chem Lett 16: 5102-6 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.031
BindingDB Entry DOI: 10.7270/Q2K9374T |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50192478
(1-(3-bromo-phenoxy)-7,8-dimethoxy-10,11-dihydro-5-...)Show InChI InChI=1S/C19H16BrN3O4/c1-24-15-6-11-9-21-17-18(26-13-5-3-4-12(20)7-13)22-10-23-19(17)27-14(11)8-16(15)25-2/h3-8,10,21H,9H2,1-2H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems Inc
Curated by ChEMBL
| Assay Description
Inhibition of KDR measured as pGAT-biotin peptide phosphorylation by HTRF assay |
Bioorg Med Chem Lett 16: 5102-6 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.031
BindingDB Entry DOI: 10.7270/Q2K9374T |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50192476
((3-bromo-phenyl)-(7,8-dimethoxy-3-methyl-10,11-dih...)Show SMILES COc1cc2CNc3c(Nc4cccc(Br)c4)nc(C)nc3Oc2cc1OC Show InChI InChI=1S/C20H19BrN4O3/c1-11-23-19(25-14-6-4-5-13(21)8-14)18-20(24-11)28-15-9-17(27-3)16(26-2)7-12(15)10-22-18/h4-9,22H,10H2,1-3H3,(H,23,24,25) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems Inc
Curated by ChEMBL
| Assay Description
Inhibition of KDR measured as pGAT-biotin peptide phosphorylation by HTRF assay |
Bioorg Med Chem Lett 16: 5102-6 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.031
BindingDB Entry DOI: 10.7270/Q2K9374T |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50192486
(1-(3-chloro-2-fluoro-phenoxy)-7,8-dimethoxy-10,11-...)Show InChI InChI=1S/C19H15ClFN3O4/c1-25-14-6-10-8-22-17-18(27-12-5-3-4-11(20)16(12)21)23-9-24-19(17)28-13(10)7-15(14)26-2/h3-7,9,22H,8H2,1-2H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems Inc
Curated by ChEMBL
| Assay Description
Inhibition of KDR measured as pGAT-biotin peptide phosphorylation by HTRF assay |
Bioorg Med Chem Lett 16: 5102-6 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.031
BindingDB Entry DOI: 10.7270/Q2K9374T |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50192493
((2-chloro-4-fluoro-phenyl)-(7,8-dimethoxy-10,11-di...)Show InChI InChI=1S/C19H16ClFN4O3/c1-26-15-5-10-8-22-17-18(25-13-4-3-11(21)6-12(13)20)23-9-24-19(17)28-14(10)7-16(15)27-2/h3-7,9,22H,8H2,1-2H3,(H,23,24,25) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems Inc
Curated by ChEMBL
| Assay Description
Inhibition of KDR measured as pGAT-biotin peptide phosphorylation by HTRF assay |
Bioorg Med Chem Lett 16: 5102-6 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.031
BindingDB Entry DOI: 10.7270/Q2K9374T |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50192504
(1-(3-chloro-4-fluoro-phenoxy)-7,8-dimethoxy-11-met...)Show SMILES COc1cc2CN(C)c3c(Oc4ccc(F)c(Cl)c4)ncnc3Oc2cc1OC Show InChI InChI=1S/C20H17ClFN3O4/c1-25-9-11-6-16(26-2)17(27-3)8-15(11)29-20-18(25)19(23-10-24-20)28-12-4-5-14(22)13(21)7-12/h4-8,10H,9H2,1-3H3 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.08E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems Inc
Curated by ChEMBL
| Assay Description
Inhibition of EGFR measured as pGAT-biotin peptide phosphorylation in presence of 2.0 uM ATP by HTRF assay |
Bioorg Med Chem Lett 16: 5102-6 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.031
BindingDB Entry DOI: 10.7270/Q2K9374T |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50192497
((7,8-dimethoxy-10,11-dihydro-5H-2,4,5,11-tetraaza-...)Show SMILES COc1cccc(CNc2ncnc3Nc4cc(OC)c(OC)cc4CNc23)c1 Show InChI InChI=1S/C21H23N5O3/c1-27-15-6-4-5-13(7-15)10-23-20-19-21(25-12-24-20)26-16-9-18(29-3)17(28-2)8-14(16)11-22-19/h4-9,12,22H,10-11H2,1-3H3,(H2,23,24,25,26) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.17E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems Inc
Curated by ChEMBL
| Assay Description
Inhibition of EGFR autophosphorylation in DiFi cells by ELISA |
Bioorg Med Chem Lett 16: 5102-6 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.031
BindingDB Entry DOI: 10.7270/Q2K9374T |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50192508
((7,8-dimethoxy-10,11-dihydro-5-thia-2,4,11-triaza-...)Show SMILES COc1cc2CNc3c(Nc4ccc5c[nH]nc5c4)ncnc3Sc2cc1OC Show InChI InChI=1S/C20H18N6O2S/c1-27-15-5-12-8-21-18-19(25-13-4-3-11-9-24-26-14(11)6-13)22-10-23-20(18)29-17(12)7-16(15)28-2/h3-7,9-10,21H,8H2,1-2H3,(H,24,26)(H,22,23,25) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.41E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems Inc
Curated by ChEMBL
| Assay Description
Inhibition of EGFR measured as pGAT-biotin peptide phosphorylation in presence of 2.0 uM ATP by HTRF assay |
Bioorg Med Chem Lett 16: 5102-6 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.031
BindingDB Entry DOI: 10.7270/Q2K9374T |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50192511
((1H-benzoimidazol-5-yl)-(7,8-dimethoxy-3-methyl-10...)Show SMILES COc1cc2CNc3c(Nc4ccc5nc[nH]c5c4)nc(C)nc3Sc2cc1OC Show InChI InChI=1S/C21H20N6O2S/c1-11-25-20(27-13-4-5-14-15(7-13)24-10-23-14)19-21(26-11)30-18-8-17(29-3)16(28-2)6-12(18)9-22-19/h4-8,10,22H,9H2,1-3H3,(H,23,24)(H,25,26,27) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.45E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems Inc
Curated by ChEMBL
| Assay Description
Inhibition of EGFR measured as pGAT-biotin peptide phosphorylation in presence of 2.0 uM ATP by HTRF assay |
Bioorg Med Chem Lett 16: 5102-6 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.031
BindingDB Entry DOI: 10.7270/Q2K9374T |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50192505
(CHEMBL214627 | benzothiazol-6-yl-(7,8-dimethoxy-3-...)Show SMILES COc1cc2CNc3c(Nc4ccc5ncsc5c4)nc(C)nc3Sc2cc1OC Show InChI InChI=1S/C21H19N5O2S2/c1-11-24-20(26-13-4-5-14-18(7-13)29-10-23-14)19-21(25-11)30-17-8-16(28-3)15(27-2)6-12(17)9-22-19/h4-8,10,22H,9H2,1-3H3,(H,24,25,26) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.52E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems Inc
Curated by ChEMBL
| Assay Description
Inhibition of EGFR measured as pGAT-biotin peptide phosphorylation in presence of 2.0 uM ATP by HTRF assay |
Bioorg Med Chem Lett 16: 5102-6 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.031
BindingDB Entry DOI: 10.7270/Q2K9374T |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50192506
((7,8-dimethoxy-3-methyl-10,11-dihydro-5-thia-2,4,1...)Show SMILES COc1cc2CNc3c(Nc4ccc5n[nH]cc5c4)nc(C)nc3Sc2cc1OC Show InChI InChI=1S/C21H20N6O2S/c1-11-24-20(26-14-4-5-15-12(6-14)10-23-27-15)19-21(25-11)30-18-8-17(29-3)16(28-2)7-13(18)9-22-19/h4-8,10,22H,9H2,1-3H3,(H,23,27)(H,24,25,26) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.62E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems Inc
Curated by ChEMBL
| Assay Description
Inhibition of EGFR measured as pGAT-biotin peptide phosphorylation in presence of 2.0 uM ATP by HTRF assay |
Bioorg Med Chem Lett 16: 5102-6 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.031
BindingDB Entry DOI: 10.7270/Q2K9374T |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50192510
((7,8-dimethoxy-3-methyl-10,11-dihydro-5-thia-2,4,1...)Show SMILES COc1cc2CNc3c(Nc4ccc5ccccc5c4)nc(C)nc3Sc2cc1OC Show InChI InChI=1S/C24H22N4O2S/c1-14-26-23(28-18-9-8-15-6-4-5-7-16(15)10-18)22-24(27-14)31-21-12-20(30-3)19(29-2)11-17(21)13-25-22/h4-12,25H,13H2,1-3H3,(H,26,27,28) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.70E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems Inc
Curated by ChEMBL
| Assay Description
Inhibition of EGFR measured as pGAT-biotin peptide phosphorylation in presence of 2.0 uM ATP by HTRF assay |
Bioorg Med Chem Lett 16: 5102-6 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.031
BindingDB Entry DOI: 10.7270/Q2K9374T |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50192481
(1-(3-chloro-2-fluoro-phenoxy)-7,8-dimethoxy-10,11-...)Show InChI InChI=1S/C19H15ClFN3O3S/c1-25-13-6-10-8-22-17-18(27-12-5-3-4-11(20)16(12)21)23-9-24-19(17)28-15(10)7-14(13)26-2/h3-7,9,22H,8H2,1-2H3 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.93E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems Inc
Curated by ChEMBL
| Assay Description
Inhibition of EGFR measured as pGAT-biotin peptide phosphorylation in presence of 2.0 uM ATP by HTRF assay |
Bioorg Med Chem Lett 16: 5102-6 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.031
BindingDB Entry DOI: 10.7270/Q2K9374T |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50192485
(1-(3-bromo-phenoxy)-7,8-dimethoxy-10,11-dihydro-5-...)Show InChI InChI=1S/C19H16BrN3O3S/c1-24-14-6-11-9-21-17-18(26-13-5-3-4-12(20)7-13)22-10-23-19(17)27-16(11)8-15(14)25-2/h3-8,10,21H,9H2,1-2H3 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.17E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems Inc
Curated by ChEMBL
| Assay Description
Inhibition of EGFR measured as pGAT-biotin peptide phosphorylation in presence of 2.0 uM ATP by HTRF assay |
Bioorg Med Chem Lett 16: 5102-6 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.031
BindingDB Entry DOI: 10.7270/Q2K9374T |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50192513
((7,8-dimethoxy-3-methyl-10,11-dihydro-5-thia-2,4,1...)Show SMILES COc1cc2CNc3c(Nc4ccc5c[nH]nc5c4)nc(C)nc3Sc2cc1OC Show InChI InChI=1S/C21H20N6O2S/c1-11-24-20(26-14-5-4-12-10-23-27-15(12)7-14)19-21(25-11)30-18-8-17(29-3)16(28-2)6-13(18)9-22-19/h4-8,10,22H,9H2,1-3H3,(H,23,27)(H,24,25,26) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.46E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems Inc
Curated by ChEMBL
| Assay Description
Inhibition of EGFR measured as pGAT-biotin peptide phosphorylation in presence of 2.0 uM ATP by HTRF assay |
Bioorg Med Chem Lett 16: 5102-6 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.031
BindingDB Entry DOI: 10.7270/Q2K9374T |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50192494
((3-chloro-phenyl)-(7,8-dimethoxy-10,11-dihydro-5-t...)Show SMILES COc1cc2CNc3c(Sc2cc1OC)ncnc3N(C)c1cccc(Cl)c1 Show InChI InChI=1S/C20H19ClN4O2S/c1-25(14-6-4-5-13(21)8-14)19-18-20(24-11-23-19)28-17-9-16(27-3)15(26-2)7-12(17)10-22-18/h4-9,11,22H,10H2,1-3H3 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.70E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems Inc
Curated by ChEMBL
| Assay Description
Inhibition of EGFR measured as pGAT-biotin peptide phosphorylation in presence of 2.0 uM ATP by HTRF assay |
Bioorg Med Chem Lett 16: 5102-6 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.031
BindingDB Entry DOI: 10.7270/Q2K9374T |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50192507
((3-bromo-phenyl)-(7,8-dimethoxy-3-methyl-10,11-dih...)Show SMILES COc1cc2CNc3c(Nc4cccc(Br)c4)nc(C)nc3Sc2cc1OC Show InChI InChI=1S/C20H19BrN4O2S/c1-11-23-19(25-14-6-4-5-13(21)8-14)18-20(24-11)28-17-9-16(27-3)15(26-2)7-12(17)10-22-18/h4-9,22H,10H2,1-3H3,(H,23,24,25) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.07E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems Inc
Curated by ChEMBL
| Assay Description
Inhibition of EGFR measured as pGAT-biotin peptide phosphorylation in presence of 2.0 uM ATP by HTRF assay |
Bioorg Med Chem Lett 16: 5102-6 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.031
BindingDB Entry DOI: 10.7270/Q2K9374T |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50192502
((3-chloro-4-fluoro-phenyl)-(7,8-dimethoxy-3-methyl...)Show SMILES COc1cc2CNc3c(Nc4ccc(F)c(Cl)c4)nc(C)nc3Sc2cc1OC Show InChI InChI=1S/C20H18ClFN4O2S/c1-10-24-19(26-12-4-5-14(22)13(21)7-12)18-20(25-10)29-17-8-16(28-3)15(27-2)6-11(17)9-23-18/h4-8,23H,9H2,1-3H3,(H,24,25,26) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 4.59E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems Inc
Curated by ChEMBL
| Assay Description
Inhibition of EGFR measured as pGAT-biotin peptide phosphorylation in presence of 2.0 uM ATP by HTRF assay |
Bioorg Med Chem Lett 16: 5102-6 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.031
BindingDB Entry DOI: 10.7270/Q2K9374T |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50192482
((3-chloro-2-fluoro-phenyl)-(7,8-dimethoxy-10,11-di...)Show InChI InChI=1S/C19H16ClFN4O2S/c1-26-13-6-10-8-22-17-18(25-12-5-3-4-11(20)16(12)21)23-9-24-19(17)28-15(10)7-14(13)27-2/h3-7,9,22H,8H2,1-2H3,(H,23,24,25) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 6.29E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems Inc
Curated by ChEMBL
| Assay Description
Inhibition of EGFR measured as pGAT-biotin peptide phosphorylation in presence of 2.0 uM ATP by HTRF assay |
Bioorg Med Chem Lett 16: 5102-6 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.031
BindingDB Entry DOI: 10.7270/Q2K9374T |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50192488
(CHEMBL211982 | benzothiazol-6-yl-(7,8-dimethoxy-10...)Show InChI InChI=1S/C20H17N5O2S2/c1-26-14-5-11-8-21-18-19(25-12-3-4-13-17(6-12)28-10-24-13)22-9-23-20(18)29-16(11)7-15(14)27-2/h3-7,9-10,21H,8H2,1-2H3,(H,22,23,25) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems Inc
Curated by ChEMBL
| Assay Description
Inhibition of EGFR measured as pGAT-biotin peptide phosphorylation in presence of 2.0 uM ATP by HTRF assay |
Bioorg Med Chem Lett 16: 5102-6 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.031
BindingDB Entry DOI: 10.7270/Q2K9374T |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50192476
((3-bromo-phenyl)-(7,8-dimethoxy-3-methyl-10,11-dih...)Show SMILES COc1cc2CNc3c(Nc4cccc(Br)c4)nc(C)nc3Oc2cc1OC Show InChI InChI=1S/C20H19BrN4O3/c1-11-23-19(25-14-6-4-5-13(21)8-14)18-20(24-11)28-15-9-17(27-3)16(26-2)7-12(15)10-22-18/h4-9,22H,10H2,1-3H3,(H,23,24,25) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems Inc
Curated by ChEMBL
| Assay Description
Inhibition of EGFR measured as pGAT-biotin peptide phosphorylation in presence of 2.0 uM ATP by HTRF assay |
Bioorg Med Chem Lett 16: 5102-6 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.031
BindingDB Entry DOI: 10.7270/Q2K9374T |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50192492
((3-chloro-2-fluoro-phenyl)-(7,8-dimethoxy-3-methyl...)Show SMILES COc1cc2CNc3c(Nc4cccc(Cl)c4F)nc(C)nc3Sc2cc1OC Show InChI InChI=1S/C20H18ClFN4O2S/c1-10-24-19(26-13-6-4-5-12(21)17(13)22)18-20(25-10)29-16-8-15(28-3)14(27-2)7-11(16)9-23-18/h4-8,23H,9H2,1-3H3,(H,24,25,26) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems Inc
Curated by ChEMBL
| Assay Description
Inhibition of EGFR measured as pGAT-biotin peptide phosphorylation in presence of 2.0 uM ATP by HTRF assay |
Bioorg Med Chem Lett 16: 5102-6 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.031
BindingDB Entry DOI: 10.7270/Q2K9374T |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50192495
((4-chloro-3-methyl-phenyl)-(7,8-dimethoxy-3-methyl...)Show SMILES COc1cc2CNc3c(Nc4ccc(Cl)c(C)c4)nc(C)nc3Sc2cc1OC Show InChI InChI=1S/C21H21ClN4O2S/c1-11-7-14(5-6-15(11)22)26-20-19-21(25-12(2)24-20)29-18-9-17(28-4)16(27-3)8-13(18)10-23-19/h5-9,23H,10H2,1-4H3,(H,24,25,26) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems Inc
Curated by ChEMBL
| Assay Description
Inhibition of EGFR measured as pGAT-biotin peptide phosphorylation in presence of 2.0 uM ATP by HTRF assay |
Bioorg Med Chem Lett 16: 5102-6 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.031
BindingDB Entry DOI: 10.7270/Q2K9374T |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50192484
((4-bromo-phenyl)-(7,8-dimethoxy-10,11-dihydro-5-ox...)Show InChI InChI=1S/C19H17BrN4O3/c1-25-15-7-11-9-21-17-18(24-13-5-3-12(20)4-6-13)22-10-23-19(17)27-14(11)8-16(15)26-2/h3-8,10,21H,9H2,1-2H3,(H,22,23,24) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems Inc
Curated by ChEMBL
| Assay Description
Inhibition of EGFR autophosphorylation in DiFi cells by ELISA |
Bioorg Med Chem Lett 16: 5102-6 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.031
BindingDB Entry DOI: 10.7270/Q2K9374T |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50192503
((3-bromo-phenyl)-(7,8-dimethoxy-10,11-dihydro-5-th...)Show SMILES COc1cc2CNc3c(Sc2cc1OC)ncnc3N(C)c1cccc(Br)c1 Show InChI InChI=1S/C20H19BrN4O2S/c1-25(14-6-4-5-13(21)8-14)19-18-20(24-11-23-19)28-17-9-16(27-3)15(26-2)7-12(17)10-22-18/h4-9,11,22H,10H2,1-3H3 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems Inc
Curated by ChEMBL
| Assay Description
Inhibition of EGFR measured as pGAT-biotin peptide phosphorylation in presence of 2.0 uM ATP by HTRF assay |
Bioorg Med Chem Lett 16: 5102-6 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.031
BindingDB Entry DOI: 10.7270/Q2K9374T |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50192470
((3-chloro-2-fluoro-phenyl)-(7,8-dimethoxy-3-methyl...)Show SMILES COc1cc2CNc3c(Nc4cccc(Cl)c4F)nc(C)nc3Oc2cc1OC Show InChI InChI=1S/C20H18ClFN4O3/c1-10-24-19(26-13-6-4-5-12(21)17(13)22)18-20(25-10)29-14-8-16(28-3)15(27-2)7-11(14)9-23-18/h4-8,23H,9H2,1-3H3,(H,24,25,26) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems Inc
Curated by ChEMBL
| Assay Description
Inhibition of EGFR measured as pGAT-biotin peptide phosphorylation in presence of 2.0 uM ATP by HTRF assay |
Bioorg Med Chem Lett 16: 5102-6 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.031
BindingDB Entry DOI: 10.7270/Q2K9374T |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50192499
((3-bromo-4-methyl-phenyl)-(7,8-dimethoxy-3-methyl-...)Show SMILES COc1cc2CNc3c(Nc4ccc(C)c(Br)c4)nc(C)nc3Sc2cc1OC Show InChI InChI=1S/C21H21BrN4O2S/c1-11-5-6-14(8-15(11)22)26-20-19-21(25-12(2)24-20)29-18-9-17(28-4)16(27-3)7-13(18)10-23-19/h5-9,23H,10H2,1-4H3,(H,24,25,26) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems Inc
Curated by ChEMBL
| Assay Description
Inhibition of EGFR measured as pGAT-biotin peptide phosphorylation in presence of 2.0 uM ATP by HTRF assay |
Bioorg Med Chem Lett 16: 5102-6 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.031
BindingDB Entry DOI: 10.7270/Q2K9374T |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50192493
((2-chloro-4-fluoro-phenyl)-(7,8-dimethoxy-10,11-di...)Show InChI InChI=1S/C19H16ClFN4O3/c1-26-15-5-10-8-22-17-18(25-13-4-3-11(21)6-12(13)20)23-9-24-19(17)28-14(10)7-16(15)27-2/h3-7,9,22H,8H2,1-2H3,(H,23,24,25) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems Inc
Curated by ChEMBL
| Assay Description
Inhibition of EGFR autophosphorylation in DiFi cells by ELISA |
Bioorg Med Chem Lett 16: 5102-6 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.031
BindingDB Entry DOI: 10.7270/Q2K9374T |
More data for this
Ligand-Target Pair | |
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